Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	hm2	hm3	ht4	ht5	ht6	ht7	ht8	ht9	cx10	cx11	cx12		cx13	cx14	cx15
show or hide all annotated terms Sex:
cardiovascular system	√	√	√	√		√	√	√	√
abnormal blood vessel morphology			√			√	√
abnormal vascular endothelial cell morphology			√
increased vascular endothelial cell number			√
decreased glomerular capillary number	√
abnormal retina vasculature morphology				√		√	√
kidney microaneurysm				√
abnormal pericyte morphology			√	√		√	√	√	√
abnormal placenta vasculature			√
abnormal placental labyrinth vasculature morphology			√
abnormal angiogenesis		√
decreased angiogenesis		√
abnormal venule morphology	√
abnormal heart morphology						√	√
myocardial fiber disarray				√
dilated heart atrium						√	√
enlarged heart				√
abnormal heart left ventricle morphology				√
dilated heart right ventricle				√
increased heart ventricle size						√	√
cardiac fibrosis						√	√
hemorrhage	√			√
eye hemorrhage						√	√
retina hemorrhage				√
kidney hemorrhage	√
glomerulus hemorrhage	√
cellular	√			√
abnormal mesangial cell morphology				√
absent mesangial cell	√
embryo			√
abnormal placenta vasculature			√
abnormal placental labyrinth vasculature morphology			√
abnormal trophoblast layer morphology			√
growth/size/body				√
enlarged heart				√
kidney cyst				√
decreased body size				√
hematopoietic system	√													N
hematopoietic system phenotype														N
anemia	√
abnormal erythrocyte morphology	√
increased nucleated erythrocyte cell number	√
anisocytosis	√
poikilocytosis	√
schistocytosis	√
polychromatophilia	√
thrombocytopenia	√
homeostasis/metabolism	√													√	√
increased blood urea nitrogen level														√	√
hydrops fetalis	√
integument	√
pallor	√
purpura	√
mortality/aging	√			√
lethality throughout fetal growth and development, incomplete penetrance	√
perinatal lethality, incomplete penetrance	√			√
postnatal lethality, incomplete penetrance				√
muscle				√										√	√
myocardial fiber disarray				√
abnormal smooth muscle morphology														√	√
renal/urinary system	√			√										√	√
kidney microaneurysm				√
kidney cyst				√
absent podocytes	√
abnormal renal glomerulus morphology				√										√	√
decreased glomerular capillary number	√
abnormal mesangial cell morphology				√
absent mesangial cell	√
glomerulosclerosis				√
abnormal kidney physiology														√	√
kidney hemorrhage	√
glomerulus hemorrhage	√
reproductive system										√	√	√	√
female infertility											√	√
male infertility										√			√
skeleton															√
abnormal skeleton morphology															√
vision/eye				√		√	√									√
eye hemorrhage						√	√
retina hemorrhage				√
abnormal eye morphology				√		√	√
abnormal retina vasculature morphology				√		√	√
retina detachment				√
abnormal vitreous body morphology																√
eye opacity						√	√
normal phenotype					√
no abnormal phenotype detected					√