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All mouse models of CADASIL with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | CADASIL 1 |
\Gt(ROSA)26Sortm2(NOTCH3*C455R)Sat/\Gt(ROSA)26Sor+ \Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg \Tg(Tagln-cre)1Her/0 |
involves: 129 * C57BL/6 * SJL | J:171887 | View | |||
| CADASIL 1 |
\Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/\Gt(ROSA)26Sor+ \Notch3Gt(PST033)Byg/\Notch3Gt(PST033)Byg \Tg(Tagln-cre)1Her/0 |
involves: 129 * C57BL/6 * SJL | J:171887 | View | ||||
| CADASIL 1 |
\Notch1tm1Grid/\Notch1+ \Notch3tm1Grid/\Notch3tm1Grid |
involves: 129S1/Sv * C57BL/6 | J:227333 | View | ||||
| CADASIL 1 | \Notch3hpbk/\Notch3hpbk | C57BL/6J-Notch3hpbk/GrsrJ | J:222308 | View | ||||
| CADASIL 1 | \Notch3tm1.1Dwr/\Notch3+ | involves: 129S/SvEv * Swiss | J:191454 | View | ||||
| CADASIL 1 | \Notch3tm1.1Dwr/\Notch3tm1.1Dwr | involves: 129S/SvEv * Swiss | J:191454 | View | ||||
| Transgenes and Other Mutations | CADASIL 1 | \Tg(Notch3*R169C)88Bbb/0 | involves: FVB/N | J:220006 | View | |||
| Additional Complex Models | CADASIL 1 |
\Gt(ROSA)26Sortm3(NOTCH3*R1031C)Sat/\Gt(ROSA)26Sor+ \Tg(Tagln-cre)1Her/0 |
involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6 * SJL | J:171887 | View | |||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | CADASIL 1 | \Notch3tm1Grid/\Notch3tm1Grid | involves: 129S1/Sv * C57BL/6 | J:227333 | View | |||
| CADASIL 1 | \Notch3tm1Ul/\Notch3+ | Not Specified | J:95927 | View | ||||
| CADASIL 1 | \Notch3tm1Ul/\Notch3tm1Ul | Not Specified | J:95927 | View | ||||