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All mouse models of hypomyelinating leukodystrophy with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | hypomyelinating leukodystrophy 2 |
\Gjb1tm1Kwi/Y \Gjc2tm1(EGFP)Kwi/\Gjc2tm1(EGFP)Kwi |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 | J:219594 | View | |||
| hypomyelinating leukodystrophy 2 |
\Gjc2tm1(EGFP)Kwi/\Gjc2tm1(EGFP)Kwi \Gjb1tm1Kwi/\Gjb1tm1Kwi |
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 | J:219594 | View | ||||
| hypomyelinating leukodystrophy 2 | \Gjc2tm2.1Kwi/\Gjc2tm2.1Kwi | involves: C57BL/6 * SJL | J:174197 | View | ||||
| hypomyelinating leukodystrophy 6 | \Tubb4aem1Avan/\Tubb4aem1Avan | involves: C57BL/6 | J:291062 | View | ||||
| hypomyelinating leukodystrophy 6 | \Tubb4aJit/\Tubb4a+ | FVB.B6-Tubb4aJit | J:321692 | View | ||||
| hypomyelinating leukodystrophy 6 | \Tubb4aJit/\Tubb4aJit | FVB.B6-Tubb4aJit | J:321692 | View | ||||
| hypomyelinating leukodystrophy 7 |
\Polr3atm1Iwil/\Polr3atm1Iwil \Olig2tm1.1(cre)Wdr/\Olig2+ |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J | J:311745 | View | ||||
| hypomyelinating leukodystrophy 7 |
\Polr3atm1Iwil/\Polr3atm1Iwil \Tg(CAG-cre/Esr1*)5Amc/0 |
Not Specified | J:364909 | View | ||||
| Pelizaeus-Merzbacher disease | \Dp(XTceal3-Plp1)1Gmh/Y | involves: 129S7/SvEvBrd * C57BL/6 | J:199809 | View | ||||
| Pelizaeus-Merzbacher disease | \Plp1jp-msd/Y | involves: BALB/c * C3H * C57BL/6 * C57BL/10 | J:121540 | View | ||||
| Pelizaeus-Merzbacher disease | \Plp1jp-rsh/Y | involves: C3H * C57BL/6 * STOCK Rb(1.3)1Bnr | J:121540 | View | ||||
| Pelizaeus-Merzbacher disease | \Plp1tm1Frca/Y | B6.129-Plp1tm1Frca | J:143305 | View | ||||
| Pelizaeus-Merzbacher disease | \Plp1tm1Kan/? | involves: 129S1/Sv * 129X1/SvJ * C57BL/6 | J:146665 | View | ||||
| Pelizaeus-Merzbacher disease | \Tg(Plp)66Kan/0 | B6NCrl.Cg-Tg(Plp)66Kan | J:156106 | View | ||||
| Pelizaeus-Merzbacher disease | \Tg(Plp)66Kan/\Tg(Plp)66Kan | B6NCrl.Cg-Tg(Plp)66Kan | J:156106 | View | ||||
| Pelizaeus-Merzbacher disease | \Tg(Plp)72Kan/\Tg(Plp)72Kan | B6N.Cg-Tg(Plp)72Kan | J:229229 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | hypomyelinating leukodystrophy 7 | \Polr3aGt(LG04)Osb/\Polr3atm1Bebr | involves: C57BL/6 * C57BL/6J * DBA/2 | J:250577 | View | |||
| hypomyelinating leukodystrophy 7 | \Polr3atm1.1Bebr/\Polr3atm1.1Bebr | involves: C57BL/6J | J:250577 | View | ||||