Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9
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cardiovascular system				√	√	√
abnormal cardiovascular development						√
abnormal heart layer morphology				√	√	√
thin myocardium						√
thin ventricular wall						√
decreased fetal cardiomyocyte proliferation						√
cellular						√
decreased fetal cardiomyocyte proliferation						√
limbs/digits/tail						√	√	√	√
hindlimb oligodactyly									√
polydactyly						√	√
preaxial polydactyly								√
mortality/aging		√	√	√	√	√
lethality throughout fetal growth and development, complete penetrance						√
embryonic lethality during organogenesis, complete penetrance		√	√
preweaning lethality, incomplete penetrance				√	√
muscle						√
thin myocardium						√
decreased fetal cardiomyocyte proliferation						√
normal phenotype	√
no abnormal phenotype detected	√