Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
hm1
hm2
cx3
cx4
cx5
show or hide all annotated terms Sex:
     
cardiovascular system
√ √ √ √ √
abnormal placental labyrinth vasculature morphology
√
internal hemorrhage
√ √
liver hemorrhage
√ √
cellular
√ √
increased polyploid hepatocyte number
√ √
digestive/alimentary system
√ √
diarrhea
√ √
abnormal intestinal epithelium morphology
√ √
abnormal colon morphology
√ √
rectal prolapse
√ √
abnormal intestinal mineral absorption
√ √
embryo
√ √ √
embryonic growth retardation
√
decreased embryo weight
√ √
abnormal allantois morphology
√
abnormal placenta morphology
√ √ √
abnormal placenta labyrinth morphology
√
abnormal placental labyrinth vasculature morphology
√
small placenta
√
abnormal trophoblast layer morphology
√ √ √
abnormal trophoblast giant cell morphology
√ √ √
increased trophoblast giant cell number
√
abnormal spongiotrophoblast layer morphology
√
abnormal spongiotrophoblast cell morphology
√
decreased spongiotrophoblast cell number
√
abnormal extraembryonic tissue physiology
√ √
impaired placental function
√ √ √
growth/size/body
√ √ √ √ √
embryonic growth retardation
√
decreased embryo weight
√ √
decreased body weight
√ √
enlarged spleen
√ √
hematopoietic system
√ √ √ √
enlarged spleen
√ √
extramedullary hematopoiesis
√ √
immune system
√ √
enlarged spleen
√ √
chronic inflammation
√ √
liver/biliary system
√ √
liver hemorrhage
√ √
abnormal hepatocyte morphology
√ √
increased polyploid hepatocyte number
√ √
hepatic necrosis
√ √
hepatic steatosis
√ √
mortality/aging
√ √ √ √ √ √ √
mortality/aging
N
embryonic lethality during organogenesis, complete penetrance
√
prenatal lethality, incomplete penetrance
√
embryonic lethality during organogenesis, incomplete penetrance
√ √ √ √ √
reproductive system
√ √
female infertility
√
reduced female fertility
√