Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
ht1
ht2
ht3
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adipose tissue
√ √
decreased subcutaneous adipose tissue amount
√ √
behavior/neurological
√ √
lethargy
√ √
cellular
√ √
abnormal cell physiology
√ √
endocrine/exocrine glands
√ √ √
increased T cell derived lymphoma incidence
√
abnormal mammary gland development
√
decreased testis weight
√
testis hypoplasia
√
growth/size/body
√ √
weight loss
√ √
hematopoietic system
√ √ √
increased T cell derived lymphoma incidence
√
decreased spleen weight
√ √
spleen hypoplasia
√ √
homeostasis/metabolism
√ √ √ √
decreased circulating insulin-like growth factor I level
√ √
abnormal physiological response to xenobiotic
√ √
increased susceptibility to xenobiotic induced morbidity/mortality
√ √
delayed wound healing
√ √
immune system
√ √ √
increased T cell derived lymphoma incidence
√
decreased spleen weight
√ √
spleen hypoplasia
√ √
integument
√ √ √
decreased subcutaneous adipose tissue amount
√ √
abnormal mammary gland development
√
sparse hair
√ √
delayed hair regrowth
√ √
thin dermal layer
√ √
liver/biliary system
√ √
decreased liver weight
√ √
liver hypoplasia
√ √
mortality/aging
√ √ √
increased susceptibility to xenobiotic induced morbidity/mortality
√ √
premature death
√ √ √
premature aging
√ √
muscle
√ √
decreased skeletal muscle mass
√ √
muscular atrophy
√ √
neoplasm
√ √ √
decreased tumor incidence
√ √
increased tumor incidence
√
increased T cell derived lymphoma incidence
√
increased lung adenoma incidence
√ √
increased sarcoma incidence
√
renal/urinary system
√ √
decreased kidney weight
√ √
renal hypoplasia
√ √
reproductive system
√
decreased testis weight
√
testis hypoplasia
√
respiratory system
√ √
increased lung adenoma incidence
√ √
skeleton
√ √
lordokyphosis
√ √
decreased bone mineral density
√ √