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All mouse models of prion disease with phenotypic similarity to the human disease
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
  | Creutzfeldt-Jakob disease | Prnptm1(PRNP)Tkit/Prnptm1(PRNP)Tkit | Not Specified | J:86603 | View | |||
| Creutzfeldt-Jakob disease |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*)#Rgab/0 |
involves: 129S7/SvEvBrd * C57BL/6 * FVB/N | J:183170 | View | ||||
| Creutzfeldt-Jakob disease |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*D177N*M128V)A21Rchi/0 |
involves: 129S7/SvEvBrd * C57BL/6 * CBA | J:142098 | View | ||||
| Creutzfeldt-Jakob disease |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi |
involves: 129S7/SvEvBrd * C57BL/6 * CBA | J:142098 | View | ||||
| Creutzfeldt-Jakob disease | Prnptm3Lnq/Prnptm3Lnq | involves: 129P2/OlaHsd * C57BL/6N | J:200974 | View | ||||
| Creutzfeldt-Jakob disease | Tg(Prnp*)#Rgab/0 | involves: C57BL/6 * FVB/N | J:183170 | View | ||||
| Creutzfeldt-Jakob disease | Tg(Prnp*D177N*M128V)A21Rchi/0 | involves: C57BL/6 * CBA | J:142098 | View | ||||
| Creutzfeldt-Jakob disease | Tg(Prnp*D177N*M128V)A21Rchi/Tg(Prnp*D177N*M128V)A21Rchi | involves: C57BL/6 * CBA | J:142098 | View | ||||
| fatal familial insomnia | Prnptm2Lnq/Prnptm2Lnq | involves: 129P2/OlaHsd * C57BL/6N | J:154937, J:200974 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*A116V*M128V)1309Jama/0 |
involves: 129S7/SvEvBrd | J:151934 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*P101L)2866Sbp/0 |
involves: 129S7/SvEvBrd * FVB/N | J:136434 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome |
Prnptm1Cwe/Prnptm1Cwe Tg(Prnp*P101L)2866Sbp/Tg(Prnp*P101L)2866Sbp |
involves: 129S7/SvEvBrd * FVB/N | J:136434 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Tg(Prnp*P101L)174Sbp/0 | involves: C57BL/6 * SJL | J:127373 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Tg(Prnp*P101L)2247Sbp/0 | involves: FVB/N | J:136434 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Tg(Prnp*P101L)2862Sbp/0 | involves: FVB/N | J:136434 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Tg(Prnp*P101L)2866Sbp/0 | involves: FVB/N | J:136434 | View | ||||
| Additional Complex Models | prion disease | Prnpem2.1(Prnp*D178N)Jwat/Prnpem2.1(Prnp*D178N)Jwat | involves: 129S4/SvJae * C57BL/6 | J:361333 | View | |||
| prion disease | Prnpem3.1(Prnp*E200K)Jwat/Prnpem3.1(Prnp*E200K)Jwat | involves: 129S4/SvJae * C57BL/6 | J:361333 | View | ||||
| variant Creutzfeldt-Jakob disease |
Prnptm1Cwe/Prnptm1Cwe Tg(PRNP)23454Sbp/0 |
involves: 129S7/SvEvBrd * FVB/N | J:236012 | View | ||||
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No similarity to the expected human disease phenotype was found.
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| Disease Term | Allelic Composition | Genetic Background | Reference | Phenotypes | ||||
| NOT Models | Creutzfeldt-Jakob disease | Prnptm1Cwe/Prnptm1Cwe | involves: 129S7/SvEvBrd * C57BL/6 | J:472 | View | |||
| Creutzfeldt-Jakob disease | Prnptm1Edin/Prnptm1Edin | 129P2/OlaHsd-Prnptm1Edin/EdinH | J:58820 | View | ||||
| Creutzfeldt-Jakob disease | Prnptm1Miy/Prnptm1Miy | involves: 129S4/SvJae * C57BL/6 | J:69186 | View | ||||
| Creutzfeldt-Jakob disease | Prnptm1Rcm/Prnptm1Rcm | 129P2/OlaHsd-Prnptm1Rcm | J:45908 | View | ||||
| fatal familial insomnia | Prnptm1Edin/Prnptm1Edin | 129P2/OlaHsd-Prnptm1Edin/EdinH | J:58820 | View | ||||
| fatal familial insomnia | Prnptm1Rcm/Prnptm1Rcm | 129P2/OlaHsd-Prnptm1Rcm | J:45908 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Prnptm1Cwe/Prnptm1Cwe | involves: 129S7/SvEvBrd * C57BL/6 | J:472 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Prnptm1Edin/Prnptm1Edin | 129P2/OlaHsd-Prnptm1Edin/EdinH | J:58820 | View | ||||
| Gerstmann-Straussler-Scheinker syndrome | Prnptm1Rcm/Prnptm1Rcm | 129P2/OlaHsd-Prnptm1Rcm | J:45908 | View | ||||