Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
hm1
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hematopoietic system
√
abnormal T cell differentiation
√
decreased B cell number
√
decreased B-1 B cell number
√
decreased central memory CD4-positive, alpha-beta T cell number
√
decreased effector memory CD4-positive, alpha-beta T cell number
√
decreased effector memory CD8-positive, alpha-beta T cell number
√
increased T cell number
√
increased CD4-positive, alpha-beta T cell number
√
increased CD8-positive, alpha-beta T cell number
√
immune system
√
abnormal T cell differentiation
√
decreased B cell number
√
decreased B-1 B cell number
√
decreased central memory CD4-positive, alpha-beta T cell number
√
decreased effector memory CD4-positive, alpha-beta T cell number
√
decreased effector memory CD8-positive, alpha-beta T cell number
√
increased T cell number
√
increased CD4-positive, alpha-beta T cell number
√
increased CD8-positive, alpha-beta T cell number
√