Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4	cn5
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cellular		√			√
abnormal neuronal migration		√
decreased cerebellar granule cell precursor proliferation					√
growth/size/body					√
postnatal growth retardation					√
nervous system		√	√	N	√
nervous system phenotype				N
abnormal neuronal migration		√
decreased cerebellar granule cell precursor proliferation					√
abnormal cortical marginal zone morphology			√
abnormal cortical plate morphology			√
abnormal cerebellum development			√
hydrocephaly					√
enlarged brain ventricles					√
abnormal cerebellar layer morphology					√
ectopic Purkinje cell					√
delaminated Purkinje cell layer					√
small cerebellum					√
normal phenotype	√
no abnormal phenotype detected	√