Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1	cn2	cn3	cn4
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growth/size/body		√	√
enlarged liver			√
enlarged spleen		√	√
hematopoietic system	√	√	√
abnormal definitive hematopoiesis		√
abnormal erythropoiesis		√
anemia		√
increased erythroid progenitor cell number		√
increased erythroblast number		√
decreased erythrocyte cell number		√
decreased hematocrit		√
decreased cellular hemoglobin content	√
decreased hemoglobin content		√
decreased mean corpuscular volume		√
abnormal lymphocyte morphology		√
abnormal B cell morphology		√
abnormal T cell morphology		√
abnormal spleen morphology		√
enlarged spleen		√	√
homeostasis/metabolism			√
homeostasis/metabolism phenotype			N
abnormal iron homeostasis			√
immune system		√	√
abnormal lymphocyte morphology		√
abnormal B cell morphology		√
abnormal T cell morphology		√
abnormal spleen morphology		√
enlarged spleen		√	√
integument	√
pallor	√
liver/biliary system			√
enlarged liver			√
liver fibrosis			√
cholestasis			√
mortality/aging	√		N	√
mortality/aging			N
prenatal lethality, complete penetrance				√
embryonic lethality during organogenesis, complete penetrance	√