Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5
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cardiovascular system	√	√	√	√	√
abnormal angiogenesis		√
patent ductus arteriosus		√		√
abnormal vascular smooth muscle morphology		√
abnormal myocardial fiber morphology	√		√
abnormal intercalated disk morphology			√		√
abnormal myocardial fiber myofibril morphology			√		√
myocardial fiber degeneration			√		√
myocardial fiber disarray			√
increased heart atrium size					√
enlarged heart			√		√
increased heart ventricle size					√
pericardial effusion			√		√
cardiac fibrosis			√		√
dilated cardiomyopathy			√		√
decreased cardiac muscle contractility			√		√
abnormal heart echocardiography feature					√
cellular	√	√	√	√	√
patent ductus arteriosus		√		√
abnormal myocardial fiber myofibril morphology			√		√
increased cardiomyocyte apoptosis	√		√
growth/size/body			√		√
enlarged heart			√		√
homeostasis/metabolism		√	√		√
pericardial effusion			√		√
abnormal cardiac thrombosis					√
abnormal atrial thrombosis					√
cyanosis		√
mortality/aging		√	√	√	√
premature death			√		√
postnatal lethality, complete penetrance		√		√
postnatal lethality, incomplete penetrance					√
muscle	√	√	√		√
abnormal vascular smooth muscle morphology		√
abnormal myocardial fiber morphology	√		√
abnormal intercalated disk morphology			√		√
abnormal myocardial fiber myofibril morphology			√		√
myocardial fiber degeneration			√		√
myocardial fiber disarray			√
dilated cardiomyopathy			√		√
decreased cardiac muscle contractility			√		√
increased cardiomyocyte apoptosis	√		√
abnormal sarcomere morphology			√		√