Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	ht1	ht2	ht3	ht4	ht5	cx6	cx7	cx8
show or hide all annotated terms Sex:
Source:	MGI	MGI	IMPC - HAR	MGI	MGI	MGI	MGI	MGI
behavior/neurological			√
hyperactivity			√
cardiovascular system	√	√
ventricular septal defect	√	√
hemorrhage		√
cellular				√
abnormal cell cycle checkpoint function				√
craniofacial	√
cleft palate	√
digestive/alimentary system	√
cleft palate	√
embryo		√
abnormal embryonic neuroepithelium morphology		√
endocrine/exocrine glands					√		√
increased T cell derived lymphoma incidence					√		√
growth/size/body	√
cleft palate	√
hematopoietic system			√	√	√		√
increased T cell derived lymphoma incidence					√		√
increased hemoglobin content			√
abnormal T cell physiology				√
homeostasis/metabolism			√	√	√
increased circulating aspartate transaminase level			√
increased incidence of tumors by ionizing radiation induction				√	√
immune system				√	√		√
increased T cell derived lymphoma incidence					√		√
abnormal T cell physiology				√
muscle					√
increased rhabdomyosarcoma incidence					√
neoplasm				√	√	√	√	√
increased tumor incidence				√	√	√		√
increased incidence of tumors by ionizing radiation induction				√	√
increased rhabdomyosarcoma incidence					√
increased lymphoma incidence					√			√
increased T cell derived lymphoma incidence					√		√
increased squamous cell carcinoma incidence					√
increased hemangiosarcoma incidence					√
nervous system	√	√
abnormal embryonic neuroepithelium morphology		√
abnormal lateral ventricle morphology		√
abnormal spinal cord central canal morphology	√
skeleton			√
abnormal bone structure			√
vision/eye	√
abnormal retina morphology	√