Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
hm1
hm2
cn3
cx4
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endocrine/exocrine glands
√ √ √ √
abnormal pancreatic alpha cell morphology
√
decreased pancreatic beta cell number
√
decreased pancreatic delta cell number
√
abnormal insulin secretion
√
decreased insulin secretion
√ √
increased insulin secretion
√ √
homeostasis/metabolism
√ √ √
homeostasis/metabolism phenotype
N
abnormal insulin secretion
√
decreased insulin secretion
√ √
increased insulin secretion
√ √
decreased circulating glucose level
√ √
increased circulating glucose level
√
increased circulating insulin level
√
impaired glucose tolerance
√
abnormal insulin clearance
√