Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	cn1	cn2
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cardiovascular system		√
abnormal aorta morphology		√
abnormal brain vasculature morphology		√
abnormal vascular smooth muscle morphology		√
homeostasis/metabolism	√
increased susceptibility to ischemic brain injury	√
muscle		√
abnormal vascular smooth muscle morphology		√
nervous system	√	√
abnormal brain vasculature morphology		√
increased susceptibility to ischemic brain injury	√