Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1		hm2		ht3	cx4
show or hide all annotated terms Sex:
behavior/neurological	√	√	√	√
increased fluid intake		√
hunched posture	√	√	√	√
growth/size/body	√	√	√	√		√
abnormal body weight						√
decreased body weight						√
weight loss	√	√	√	√
hematopoietic system		√
decreased hematocrit		√
homeostasis/metabolism	√	√	√	√		√
increased blood urea nitrogen level	√	√
abnormal urine nucleoside level	√	√	√	√		√
decreased urine uric acid level	√	√	√	√
crystalluria	√	√
immune system	√	√	√	√
kidney inflammation	√	√	√	√
integument	√	√	√	√
disheveled coat	√	√	√	√
mortality/aging	√	√	√	√		√
premature death	√	√	√	√
postnatal lethality						√
renal/urinary system	√	√	√	√	√	√
abnormal urine nucleoside level	√	√	√	√		√
decreased urine uric acid level	√	√	√	√
crystalluria	√	√
kidney inflammation	√	√	√	√
abnormal kidney morphology						√
kidney collecting duct atrophy				√
decreased kidney weight		√
kidney atrophy	√	√
renal tubule atrophy			√	√
dilated renal tubule	√	√
renal tubular necrosis	√	√
nephrolithiasis	√	√	√	√	√
renal fibrosis	√	√
renal interstitial fibrosis			√	√
cystolithiasis	√	√	√	√
decreased creatinine clearance		√
polyuria		√
reproductive system	N	N	√	√
reproductive system phenotype	N	N
reduced fertility			√	√