Title Page
Table of Contents
Chapter 1: An Introduction to Mice
1.1 Of mice, men, and a woman
1.2 The origin of mice in genetic research
1.3 The new biology and the mouse model
Chapter 2: Town Mouse, Country Mouse
2.1 What are mice?
2.2 Where do mice come from?
2.3 Systematics of the Mus species group
2.4 Lifestyles and adaptability of wild house mice
Chapter 3: Laboratory Mice
3.1 Sources of laboratory mice
3.2 Mouse crosses and standard strains
3.3 Coisogenics, congenics, and other specialized strains
3.4 Standardized nomenclature
3.5 Strategies for record-keeping
Chapter 4: Reproduction and Breeding
4.1 Reproductive performance: comparison of inbred strains
4.2 Germ cell differentiation and sexual maturation
4.3 Mating and pregnancy
4.4 The postnatal period
4.5 Assisted reproduction for the infertile cross
Chapter 5: The Mouse Genome
5.1 Quantifying the genome
5.2 Karyotypes, chromosomes, and translocations
5.3 Genomic elements, genome evolution, and gene families
5.4 Repetitive "non-functional" DNA families
5.5 Genomic imprinting
Chapter 6: Mutagenesis and Transgenesis
6.1 Classical mutagenesis
6.2 Embryo manipulation: genetic considerations
6.3 Transgenic mice formed by nuclear injection
6.4 Targeted mutagenesis and gene replacement
6.5 Further uses of transgenic technologies
Chapter 7: Mapping in the mouse: An overview
7.1 Genetic maps come in various forms
7.2 Mendel's genetics, linkage, and the mouse
7.3 General strategies for mapping mouse loci
7.4 The final chapter of genetics
Chapter 8: Genetic Markers
8.1 Genotypic and phenotypic variation
8.2 Restriction fragment length polymorphisms
8.3 Polymorphisms detected by PCR
8.4 Region-specific panels of DNA markers
Chapter 9: Classical Linkage Analysis and Mapping Panels
9.1 Demonstration of linkage and statistical analysis
9.2 Recombinant inbred strains
9.3 Interspecific mapping panels
9.4 Starting from scratch with a new mapping project
9.5 Quantitative traits and polygenic analysis
Chapter 10: Non-breeding Mapping Strategies
10.1 Linkage maps without breeding
10.2 Chromosomal mapping tools
10.3 Physical maps and positional cloning
10.4 The Human Genome Project and the ultimate map
A. Suppliers of Mice
B. Computational Tools and Electronic Databases
C. Source Materials for Further Reading
D. Statistics
E. Glossary of Terms

User's Guide
MGI Glossary