Cntnap3 MGI Mouse Gene Detail - MGI:3588199 - contactin associated protein-like 3

Symbol

Cntnap3
Name

contactin associated protein-like 3

Feature Type

protein coding gene
IDs

MGI:3588199
NCBI Gene: 238680
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr13:64885405-65051845 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 33.46 cM
Mapping Data

1 experiment

SNPs within 2kb

1697 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3588199	protein coding gene	Chr13:64883996-65051845 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020681	protein coding gene	Chr13:64764511-64928145 (-)
A/J	MGP_AJ_G0020635	protein coding gene	Chr13:62411087-62568137 (-)
AKR/J	MGP_AKRJ_G0020612	protein coding gene	Chr13:64476527-64641169 (-)
BALB/cJ	MGP_BALBcJ_G0020633	protein coding gene	Chr13:62841039-62996329 (-)
C3H/HeJ	MGP_C3HHeJ_G0020428	protein coding gene	Chr13:64016313-64173325 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021069	protein coding gene	Chr13:66863886-67039643 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018645	protein coding gene	Chr13:60056966-60211578 (-)
CAST/EiJ	MGP_CASTEiJ_G0019945	protein coding gene	Chr13:64018697-64189092 (-)
CBA/J	MGP_CBAJ_G0020388	protein coding gene	Chr13:69434987-69611628 (-)
DBA/2J	MGP_DBA2J_G0020513	protein coding gene	Chr13:62251783-62405040 (-)
FVB/NJ	MGP_FVBNJ_G0020492	protein coding gene	Chr13:61344256-61495139 (-)
LP/J	MGP_LPJ_G0020587	protein coding gene	Chr13:65059314-65221803 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020521	protein coding gene	Chr13:68361389-68543700 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021111	protein coding gene	Chr13:63807669-63964217 (-)
PWK/PhJ	MGP_PWKPhJ_G0019699	protein coding gene	Chr13:61800515-61958409 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019525	protein coding gene	Chr13:61973727-62150648 (-)
WSB/EiJ	MGP_WSBEiJ_G0020005	protein coding gene	Chr13:64279367-64448243 (-)

Human Ortholog

CNTNAP3, contactin associated protein family member 3

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNTNAP3, contactin associated protein family member 3
Synonyms

CASPR3, CNTNAP3A
Links

HGNC:13834

NCBI Gene ID: 79937

neXtProt AC: NX_Q9BZ76

UniProt: Q9BZ76
Chr Location

9p12; chr9:39072767-39288303 (-) GRCh38.p7

Human Ortholog

CNTNAP3B, contactin associated protein family member 3B
Links

HGNC:32035

NCBI Gene ID: 728577

neXtProt AC: NX_Q96NU0

UniProt: Q96NU0
Chr Location

9p11.2; chr9:41891887-42129504 (-) GRCh38.p7

Human Ortholog

CNTNAP3C, contactin associated protein family member 3C
Links

HGNC:53878

NCBI Gene ID: 100289279
Chr Location

chr9:61330592-61461349 (+) GRCh38.p7

Alliance of Genome Resources

Cntnap3 stringent orthology
3 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CNTNAP3, CNTNAP3B, CNTNAP3C
Gene Tree

Cntnap3

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

2
Genomic Mutations

1 involving Cntnap3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

40 strains or lines available

Mice homozygous for a knock-out allele exhibit normal brain morphology but impaired motor learning.

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All GO Annotations

2
GO References

1

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

3
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Cntnap3 interacts with 162 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

30
RefSeq

4
UniProt

2
CCDS

CCDS36703.1

Ensembl

ENSMUSG00000033063 (Evidence)
NCBI Gene

238680

			Length	Strain/Species	Flank
genomic	238680	NCBI Gene Model \| MGI Sequence Detail	166441	C57BL/6J	± kb
transcript	NM_001081129	RefSeq \| MGI Sequence Detail	6367	C57BL/6
polypeptide	NP_001074598	RefSeq \| MGI Sequence Detail	1287	C57BL/6

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UniProt

2 Sequences
InterPro Domains

IPR000421 Coagulation factor 5/8 C-terminal domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR036056 Fibrinogen-like, C-terminal

IPR008979 Galactose-binding-like domain superfamily

IPR001791 Laminin G domain

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All nucleic 5

cDNA 5

Microarray probesets 6

Summaries

All 25

Developmental Gene Expression 4

Gene Ontology 1

Phenotypes 9
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:321279 Cui W, et al., In trans neuregulin3-Caspr3 interaction controls DA axonal bassoon cluster development. Curr Biol. 2021 Aug 9;31(15):3330-3342.e7

TSS for Cntnap3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr123065	Chr13:65051763-65051809 (-)	59 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 03/14/2023 MGI 6.22