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Oxct2a Gene Detail
Summary
  • Symbol
    Oxct2a
  • Name
    3-oxoacid CoA transferase 2A
  • Synonyms
    Oxct2, Scot-t1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891061
    NCBI Gene: 64059
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:123215668-123217427 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 57.42 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    28 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891061
 protein coding gene Chr4:123215668-123217472 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028733
 protein coding gene Chr4:124534338-124536097 (+)
A/J MGP_AJ_G0028692
 protein coding gene Chr4:119672382-119676831 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0028715
 protein coding gene Chr4:120258702-120260463 (+)
C3H/HeJ MGP_C3HHeJ_G0028430
 protein coding gene Chr4:123019137-123022621 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0027862
 protein coding gene Chr4:121017838-121019399 (+)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028544
 protein coding gene Chr4:120174401-120176251 (+)
FVB/NJ MGP_FVBNJ_G0028511
 protein coding gene Chr4:118797211-118800233 (+)
LP/J MGP_LPJ_G0028645
 protein coding gene Chr4:124814062-124817525 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0029194
 protein coding gene Chr4:123283220-123284892 (+)
PWK/PhJ MGP_PWKPhJ_G0027581
 protein coding gene Chr4:116388378-116389975 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0027948
 protein coding gene Chr4:123578070-123579634 (-)



Homology
more
  • Human Ortholog
    OXCT2, 3-oxoacid CoA-transferase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OXCT2, 3-oxoacid CoA-transferase 2
  • Synonyms
    FKSG25, SCOTT
  • Links
    NCBI Gene ID: 64064
    neXtProt AC: NX_Q9BYC2
    UniProt: Q9BYC2

  • Chr Location
    1p34.2; chr1:39769523-39771348 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    7 phenotype references
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    4 involving Oxct2a
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    20 strains or lines available
Male mice homozygous for a null allele exhibit normal fecundity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    810
  • Tissues
    96
  • cDNA Data
    5
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000076436 Ensembl Gene Model | MGI Sequence Detail 1760 C57BL/6J ±  kb
transcript ENSMUST00000102640 Ensembl | MGI Sequence Detail 1760 Not Applicable  
polypeptide ENSMUSP00000099700 Ensembl | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    Genomic 1
    cDNA 7

    Microarray probesets 2
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 7
  • Earliest
    J:65840 Koga M, et al., Isolation and characterization of a haploid germ cell-specific novel complementary deoxyribonucleic acid; testis-specific homologue of succinyl CoA:3-Oxo acid CoA transferase. Biol Reprod. 2000 Dec;63(6):1601-9
  • Latest
    J:344957 Zhang L, et al., AMPKalpha2 regulates fasting-induced hyperketonemia by suppressing SCOT ubiquitination and degradation. Sci Rep. 2024 Jan 19;14(1):1713
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory