| Gene Summary for NIH-0617 |
|---|
| Functional Category: |
signal transduction |
| Cell Location: |
integral membrane |
| OST #: |
105469 |
| Mouse Nucleotide Accession #: |
NM_010254 |
| Human Nucleotide Accession #: |
NM_003857 |
|
|
| Summary: |
| The targeted mouse gene is Galr2 (galanin receptor 2), ortholog of human GALR2. Aliases include mGalR and GALNR2. |
|
| Phenotypic Summary for NIH-0617 |
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| The homozygous mutant mice exhibited a decreased rearing response during open field testing when compared with that of their wild-type littermates, suggesting decreased exploratory behavior in these mutants. Consistent with this phenotype, 4 of 7 homozygous mutant mice did not rear during the functional observational battery. A slight increase in the mean percentage of CD4 cells and a slight decrease in the mean percentage of B cells were also noted in the homozygous mutant mice. RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. |
| Mouse Gene Sequence Information |
|---|
 |
Nucleotide Reference: |
NM_010254 Mus musculus galanin receptor 2 (Galr2), mRNA. |
|
Protein Reference: |
AAC36589 galanin receptor type 2 [Mus musculus] |
|
Entrez Gene: |
14428 |
| Human Gene Sequence Information |
|---|
|
Nucleotide Reference: |
NM_003857 NM_003857 ACCESSION:NM_003857 NID:na Homo sapiens Homo sapiens galanin receptor 2 (GALR2), mRNA. hs_refseq |
|
Protein Reference: |
NP_003848 galanin receptor 2 [Homo sapiens] |
|
Entrez Gene: |
8811 |
| Mutation Information |
|---|
| Mutation Type: |
Retroviral Insertion (OST) |
| Description: |
The mouse gene consists of 2 exons, with the start codon located in exon 1 (NCBI accession NM_010254). Retroviral insertion occurred in the intron between exons 1 and 2. |
|
