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      "id" : "http://purl.obolibrary.org/obo/CHEBI_55370",
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      "lbl" : "ATP(3-)",
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      "lbl" : "glycine zwitterion",
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        },
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      "lbl" : "long-chain fatty acid anion",
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          "val" : "a long-chain fatty acid",
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      "lbl" : "ethanolaminium(1+)",
      "type" : "CLASS",
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      "lbl" : "creatine zwitterion",
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      "lbl" : "primary aliphatic ammonium ion",
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          "val" : "primary aliphatic ammonium cation",
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      "id" : "http://purl.obolibrary.org/obo/CHEBI_58065",
      "lbl" : "homocysteine zwitterion",
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          "val" : "2-ammonio-4-sulfanylbutanoate",
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      "lbl" : "L-phenylalanine zwitterion",
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      "lbl" : "nucleoside 5'-triphoshate(3-)",
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          "val" : "NTP(3-)",
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          "val" : "ribonucleoside triphosphate trianion",
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          "val" : "ribonucleoside triphosphate trianion",
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      "lbl" : "(2S)-2-hydroxy monocarboxylic acid anion",
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          "val" : "(2S)-2-hydroxy monocarboxylic acid anions",
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          "val" : "(2S)-2-hydroxycarboxylate",
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          "val" : "(2S)-alpha-hydroxy monocarboxylic acid anion",
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          "val" : "(S)-2-hydroxyacid anion",
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      "lbl" : "(2R)-2-hydroxy monocarboxylic acid anion",
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          "val" : "A hydroxy monocarboxylic acid anion where the hydroxy group is placed at position 2 (α to the carboxy group) and has (<i>R</i>)-stereochemistry; major species at pH 7.3."
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          "val" : "(2R)-2-hydroxycarboxylate",
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          "pred" : "hasRelatedSynonym",
          "val" : "(2R)-alpha-hydroxy monocarboxylic acid anion",
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          "val" : "(R)-2-hydroxyacid anion",
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      "lbl" : "trimethylammonium",
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          "val" : "trimethylazanium",
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          "val" : "trimethylazanium cation",
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      "lbl" : "histaminium",
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      "lbl" : "indole skeleton",
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          "xrefs" : [ "ChEBI" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "AVP",
          "xrefs" : [ "chebi" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Antidiuretic hormone",
          "xrefs" : [ "KEGG_COMPOUND" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Antidiuretic hormone",
          "xrefs" : [ "kegg.compound" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "VP",
          "xrefs" : [ "KEGG_COMPOUND" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "VP",
          "xrefs" : [ "kegg.compound" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Vasopressin",
          "xrefs" : [ "kegg.compound" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "arginine vasopressin",
          "xrefs" : [ "ChEBI" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "arginine vasopressin",
          "xrefs" : [ "chebi" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "argipressin",
          "xrefs" : [ "ChEBI" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "argipressin",
          "xrefs" : [ "chebi" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "beta-Hypophamine",
          "xrefs" : [ "ChemIDplus" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "beta-Hypophamine",
          "xrefs" : [ "chemidplus" ]
        } ],
        "xrefs" : [ {
          "val" : "KEGG:C00840"
        }, {
          "val" : "KEGG:D00101"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "chebi_ontology"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000008",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000009",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000026",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000027",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000032",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000041",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000043",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000046",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000047",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000053",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000054",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000056",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CLM_1000061",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000000",
      "lbl" : "cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A material entity of anatomical origin (part of or deriving from an organism) that has as its parts a maximally connected cell compartment surrounded by a plasma membrane.",
          "xrefs" : [ "CARO:mah" ]
        },
        "comments" : [ "The definition of cell is intended to represent all cells, and thus a cell is defined as a material entity and not an anatomical structure, which implies that it is part of an organism (or the entirety of one)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/ubprop#_upper_level" ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2035"
        }, {
          "val" : "FMA:68646"
        }, {
          "val" : "GO:0005623"
        }, {
          "val" : "KUPO:0000002"
        }, {
          "val" : "MESH:D002477"
        }, {
          "val" : "VHOG:0001533"
        }, {
          "val" : "WBbt:0004017"
        }, {
          "val" : "XAO:0003012"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000005",
      "lbl" : "neural crest derived fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any fibroblast that is derived from the neural crest.",
          "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "fibroblast neural crest derived"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000006",
      "lbl" : "neuronal receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any sensory receptor cell that is a(n) neuron and is capable of some detection of stimulus involved in sensory perception.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuronal receptor cell (sensu Animalia)"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000007",
      "lbl" : "early embryonic cell (metazoa)",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found in the embryo before the formation of all the gem layers is complete.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000008",
      "lbl" : "migratory cranial neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell that is part of the migratory cranial neural crest population. Migratory cranial neural crest cells develop from premigratory cranial neural crest cells and have undergone epithelial to mesenchymal transition and delamination.",
          "xrefs" : [ "ZFA:0007091", "https://orcid.org/0000-0001-5208-3432" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000011",
      "lbl" : "migratory trunk neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell that is part of the migratory trunk neural crest population. Migratory trunk neural crest cells develop from premigratory trunk neural crest cells and have undergone epithelial to mesenchymal transition and delamination.",
          "xrefs" : [ "ZFA:0007095", "https://orcid.org/0000-0001-5208-3432" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000014",
      "lbl" : "germ line stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that is the precursor of gametes.",
          "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "germline stem cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000015",
      "lbl" : "male germ cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A germ cell that supports male gamete production. In some species, non-germ cells known as Sertoli cells also play a role in spermatogenesis.",
          "xrefs" : [ "PMID:29462262", "https://orcid.org/0000-0001-5208-3432" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:72290"
        }, {
          "val" : "MA:0002765"
        }, {
          "val" : "VHOG:0001531"
        }, {
          "val" : "ncithesaurus:Spermatogenic_Cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000017",
      "lbl" : "spermatocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A male germ cell that develops from spermatogonia. The euploid primary spermatocytes undergo meiosis and give rise to the haploid secondary spermatocytes which in turn give rise to spermatids.",
          "xrefs" : [ "GOC:tfm", "MESH:D013090" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001275"
        }, {
          "val" : "CALOHA:TS-0951"
        }, {
          "val" : "EMAPA:31484"
        }, {
          "val" : "FMA:84049"
        }, {
          "val" : "WBbt:0006799"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000018",
      "lbl" : "spermatid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A male germ cell that develops from the haploid secondary spermatocytes. Without further division, spermatids undergo structural changes and give rise to spermatozoa.",
          "xrefs" : [ "MESH:D013087" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nematoblast"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001274"
        }, {
          "val" : "CALOHA:TS-0950"
        }, {
          "val" : "EMAPA:31486"
        }, {
          "val" : "FMA:72294"
        }, {
          "val" : "WBbt:0006800"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000019",
      "lbl" : "sperm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature male germ cell that develops from a spermatid.",
          "xrefs" : [ "GOC:tfm", "MESH:D013094" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "sperm cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "spermatozoid"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "spermatozoon"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001277"
        }, {
          "val" : "BTO:0002046"
        }, {
          "val" : "CALOHA:TS-0949"
        }, {
          "val" : "FMA:67338"
        }, {
          "val" : "WBbt:0006798"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000020",
      "lbl" : "spermatogonium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An euploid male germ cell of an early stage of spermatogenesis.",
          "xrefs" : [ "MESH:D013093" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "spermatogonial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000958"
        }, {
          "val" : "CALOHA:TS-2193"
        }, {
          "val" : "EMAPA:31482"
        }, {
          "val" : "FMA:72291"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000021",
      "lbl" : "female germ cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Female germ cell is a germ cell that supports female gamete production.",
          "xrefs" : [ "GOC:tfm", "PMID:11023867", "PMID:20454446" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "MA:0000388"
        }, {
          "val" : "VHOG:0001530"
        }, {
          "val" : "ncithesaurus:Egg"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000022",
      "lbl" : "female germ line stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that is the precursor of female gametes.",
          "xrefs" : [ "doi:10.1016/j.stem.2012.05.016" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000023",
      "lbl" : "oocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A female germ cell that has entered meiosis.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "oogonium"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000964"
        }, {
          "val" : "CALOHA:TS-0711"
        }, {
          "val" : "FMA:18644"
        }, {
          "val" : "MESH:D009865"
        }, {
          "val" : "WBbt:0006797"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000024",
      "lbl" : "oogonial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An undifferentiated germ cell that proliferates rapidly and gives rise to oocytes.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:83673"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000025",
      "lbl" : "egg cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A female gamete where meiosis has progressed to metaphase II and is able to participate in fertilization.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature oocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ovum"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000369"
        }, {
          "val" : "BTO:0003801"
        }, {
          "val" : "CALOHA:TS-2191"
        }, {
          "val" : "FMA:67343"
        }, {
          "val" : "MESH:D010063"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000027",
      "lbl" : "smooth muscle cell neural crest derived",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell derived from the neural crest.",
          "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000029",
      "lbl" : "neural crest derived neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that develops from some migratory neural crest cell.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuron neural crest derived"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000030",
      "lbl" : "glioblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-terminally differentiated cell that develops form the neuroectoderm. Glioblast has the potential to differentiate into various types of glial cells, including astrocytes and oligodendrocytes.",
          "xrefs" : [ "PMID:37824650", "Wikipedia:Glioblast" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000031",
      "lbl" : "neuroblast (sensu Vertebrata)",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that will develop into a neuron often after a migration phase.",
          "xrefs" : [ "GOC:NV", "http://en.wikipedia.org/wiki/Neuroblast" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuroblast"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000930"
        }, {
          "val" : "FMA:70563"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000034",
      "lbl" : "stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A relatively undifferentiated cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells.",
          "xrefs" : [ "GOC:tfm", "MESH:D013234" ]
        },
        "comments" : [ "This term applies to metazoan. For plant stem cells, consider using PO:0004011 ‘initial cell’ or its parent PO:0004010 ‘meristematic cell’." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "animal stem cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "animal stem cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2086"
        }, {
          "val" : "FMA:63368"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000035",
      "lbl" : "single fate stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that self-renews as well as give rise to a single mature cell type.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "unipotent stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "unipotential stem cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70569"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000036",
      "lbl" : "epithelial fate stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A somatic stem cell that is committed to an epithelial fate, possessing the capacity for self-renewal and the ability to differentiate into one or more distinct mature cell types of the epithelial lineage. This cell is crucial for the development, homeostasis, repair, and regeneration of epithelial tissues.",
          "xrefs" : [ "PMID:17289566", "doi:/10.1038/sj.eye.6700575" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial stem cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000037",
      "lbl" : "hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system. Hematopoietic stem cells lack cell markers of effector cells (lin-negative). Lin-negative is defined by lacking one or more of the following cell surface markers: CD2, CD3 epsilon, CD4, CD5 ,CD8 alpha chain, CD11b, CD14, CD19, CD20, CD56, ly6G, ter119.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19022770", "http://en.wikipedia.org/wiki/Hematopoietic_stem_cell" ]
        },
        "comments" : [ "Markers differ between species, and two sets of markers have been described for mice. HSCs are reportedly CD34-positive, CD45-positive, CD48-negative, CD150-positive, CD133-positive, and CD244-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "blood forming stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hemopoietic stem cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit hematopoietic"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000725"
        }, {
          "val" : "CALOHA:TS-0448"
        }, {
          "val" : "FMA:86475"
        }, {
          "val" : "MESH:D006412"
        }, {
          "val" : "VHOG:0001485"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000038",
      "lbl" : "erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell committed to the erythroid lineage.",
          "xrefs" : [ "GOC:add", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "blast forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "burst forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "erythroid stem cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004911"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000039",
      "lbl" : "germ line cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is within the developmental lineage of gametes and is able to pass along its genetic material to offspring.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "comments" : [ "Originally this term had some plant germ line cell children." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/ubprop#_upper_level" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000040",
      "lbl" : "monoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myeloid progenitor cell committed to the monocyte lineage. This cell is CD11b-positive, has basophilic cytoplasm, euchromatin, and the presence of a nucleolus.",
          "xrefs" : [ "GOC:add", "PMID:1104740", "http://en.wikipedia.org/wiki/Monoblast", "http://www.copewithcytokines.de" ]
        },
        "comments" : [ "Morphology: mononuclear cell, diameter 12-20 _M, non-granular, N/C ratio 3/1 - 4/1; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; fetal: liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit macrophage"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit monocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "monocyte stem cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1195"
        }, {
          "val" : "FMA:83553"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000047",
      "lbl" : "neural stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An undifferentiated neural cell that originates from the neuroectoderm and has the capacity both to perpetually self-renew without differentiating and to generate multiple central nervous system neuronal and glial cell types.",
          "xrefs" : [ "PMID:30639325" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "NSC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neuronal stem cell",
          "xrefs" : [ "PMID:16305818" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002881"
        }, {
          "val" : "CALOHA:TS-2360"
        }, {
          "val" : "FMA:86684"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000048",
      "lbl" : "multi fate stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that can give rise to multiple lineages of cells.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "multi-fate stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multifate stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multipotent cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multipotent stem cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84789"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000049",
      "lbl" : "common myeloid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages.",
          "xrefs" : [ "GOC:add", "ISBN:0878932437", "MESH:D023461" ]
        },
        "comments" : [ "This cell type is intended to be compatible with any vertebrate common myeloid progenitor.  For mammalian CMP known to be CD34-positive, please use the term 'common myeloid progenitor, CD34-positive' (CL_0001059)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "common myeloid precursor"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "multipotential myeloid stem cell",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "myeloid stem cell",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pluripotent stem cell (bone marrow)",
          "xrefs" : [ "ISBN:0878932437" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004730"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000050",
      "lbl" : "megakaryocyte-erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell committed to the megakaryocyte and erythroid lineages.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D055015", "PMID:16647566", "http://en.wikipedia.org/wiki/Megakaryocyte-erythroid_progenitor_cell" ]
        },
        "comments" : [ "MEPs are reportedly CD19-negative, CD34-negative, CD45RA-negative, CD110-positive, CD117-positive, and SCA1-negative and reportedly express the transcription factors GATA-1 and NF-E2." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CFU-EM"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CFU-MegE"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "MEP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Meg/E progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "colony forming unit erythroid megakaryocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megakaryocyte/erythrocyte progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megakaryocyte/erythroid progenitor cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000051",
      "lbl" : "common lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A oligopotent progenitor cell committed to the lymphoid lineage.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:10407577", "PMID:16551251" ]
        },
        "comments" : [ "CLP are CD7-positive, CD10-positive, CD19-negative, CD34-positive, CD45RA-positive, CD79a-negative, CD127-positive, AA4.1-positive, RAG-negative, Sca-1-low, sIgM-negative, sIgD-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Expression of transcription factors include E2A-positive, EBF-positive, Ikaros-negative, PU.1-negative, and Pax5-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "common lymphocyte precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "common lymphocyte progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "common lymphoid precursor"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "committed lymphopoietic stem cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "early lymphocyte progenitor"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lymphoid stem cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lymphopoietic stem cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000052",
      "lbl" : "totipotent stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell from which all cells of the body can form.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "totipotential stem cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84790"
        }, {
          "val" : "MESH:D039901"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000056",
      "lbl" : "myoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is commited to differentiating into a muscle cell.  Embryonic myoblasts develop from the mesoderm. They undergo proliferation, migrate to their various sites, and then differentiate into the appropriate form of myocytes.  Myoblasts also occur as transient populations of cells in muscles undergoing repair.",
          "xrefs" : [ "GOC:tfm", "MESH:D032446", "PMID:21849021" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0000222"
        }, {
          "val" : "CALOHA:TS-0650"
        }, {
          "val" : "FMA:70335"
        }, {
          "val" : "VHOG:0001529"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000057",
      "lbl" : "fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.",
          "xrefs" : [ "ISBN:0517223651", "MESH:D005347", "http://en.wikipedia.org/wiki/Fibroblast" ]
        },
        "comments" : [ "These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000452"
        }, {
          "val" : "CALOHA:TS-0362"
        }, {
          "val" : "FMA:63877"
        }, {
          "val" : "NCIT:C12482"
        }, {
          "val" : "VHOG:0001482"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000058",
      "lbl" : "chondroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that is typically non-terminally differentiated, secretes an avascular, GAG rich matrix; is not buried in cartilage tissue matrix, retains the ability to divide, located adjacent to cartilage tissue (including within the perichondrium), and develops from prechondroblast (and thus prechondrogenic) cell.",
          "xrefs" : [ "GOC:tfm", "GO_REF:0000034", "ISBN:0618947256" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chrondoplast"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003607"
        }, {
          "val" : "FMA:66783"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000059",
      "lbl" : "ameloblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that produces enamel, overlies the odontogenic papilla, and arises from the differentiation of a preameloblast cell.",
          "xrefs" : [ "GOC:tfm", "GO_REF:0000034", "MESH:D000565" ]
        },
        "comments" : [ "non-encoded relationship from VSAO produces VSAO:0000066" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amelocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "enamel secreting cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001663"
        }, {
          "val" : "FMA:70576"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000060",
      "lbl" : "odontoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that secretes dentine matrix, is derived from the odontogenic papilla, and develops from a preodontoblast cell.",
          "xrefs" : [ "GO_REF:0000034", "ISBN:0618947256" ]
        },
        "comments" : [ "legacy def: One of the cells forming the outer surface of dental pulp that produces tooth dentin." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001769"
        }, {
          "val" : "CALOHA:TS-0696"
        }, {
          "val" : "FMA:62999"
        }, {
          "val" : "MESH:D009804"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000061",
      "lbl" : "cementoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that produces cementum (a bony substance that covers the root of a tooth), is part of the odontogenic papilla, and develops from a precementoblast cell.",
          "xrefs" : [ "GO_REF:0000034", "ISBN:0781733901" ]
        },
        "comments" : [ "Legacy def: A cell of ectomesenchymal origin that aids in the formation the cementum layer on the roots of teeth." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cementum secreting cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1164"
        }, {
          "val" : "FMA:63002"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000062",
      "lbl" : "osteoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell.",
          "xrefs" : [ "GO_REF:0000034", "MESH:D010006" ]
        },
        "comments" : [ "non-encoded relationships from VSAO - capable_of_producing VSAO:0000020" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001593"
        }, {
          "val" : "CALOHA:TS-0720"
        }, {
          "val" : "FMA:66780"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000064",
      "lbl" : "ciliated cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that has a filiform extrusion of the cell surface.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "VHOG:0001532"
        }, {
          "val" : "XAO:0000031"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000065",
      "lbl" : "ependymal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroepithelial glial cell, derived from a radial glial cell originating from the neuroectoderm, lines the ventricles of the brain and the central canal of the spinal cord. This cell is characterized by the presence of cilia on its apical surface, which can be motile or non-motile.",
          "xrefs" : [ "GOC:tfm", "JB:jb", "PMID:34335193", "PMID:37008045", "PMID:9550134", "doi:/10.3389/fncel.2021.703951", "https://www.britannica.com/science/ependymal-cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "ependymocyte",
          "xrefs" : [ "doi:10.53347/rID-51713" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001724"
        }, {
          "val" : "FMA:70550"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000066",
      "lbl" : "epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is usually found in a two-dimensional sheet with a free surface. The cell has a cytoskeleton that allows for tight cell to cell contact and for cell polarity where apical part is directed towards the lumen and the basal part to the basal lamina.",
          "xrefs" : [ "FB:ma", "GOC:tfm", "MESH:D004847" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epitheliocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000414"
        }, {
          "val" : "CALOHA:TS-2026"
        }, {
          "val" : "CARO:0000077"
        }, {
          "val" : "FMA:66768"
        }, {
          "val" : "WBbt:0003672"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000067",
      "lbl" : "ciliated epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that has a cilia.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:70605"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000068",
      "lbl" : "duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of a duct.",
          "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000069",
      "lbl" : "branched duct epithelial cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000071",
      "lbl" : "blood vessel endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that lines the vasculature.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000072",
      "lbl" : "non-branched duct epithelial cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000075",
      "lbl" : "columnar/cuboidal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.",
          "xrefs" : [ "GO:0002065", "https://orcid.org/0000-0001-5208-3432" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000076",
      "lbl" : "squamous epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that has a flattened morphology."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1249"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2025-12-16T15:56:39Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000077",
      "lbl" : "mesothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A flat, squamous-like epithelial cell of mesodermal origin. It forms the mesothelium, which lines the body's serous cavities including the pleural, peritoneal, and pericardial spaces. This cell plays a crucial role in synthesizing and secreting lubricants, such as glycosaminoglycans and surfactants, which minimize friction between adjacent tissues during movement.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "PMID:26106328" ]
        },
        "comments" : [ "Mesothelial cells, which morphologically resemble squamous epithelial cells, express both epithelial markers (cytokeratins) and mesenchymal markers (vimentin), reflecting their mesodermal origin. They feature surface microvilli and apical-basal polarity. Under certain conditions, they can undergo mesothelial-to-mesenchymal transition. These cells also produce extracellular matrix proteins, maintain serosal homeostasis, and facilitate fluid transport." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mesotheliocyte"
        } ],
        "xrefs" : [ {
          "val" : "FMA:66773"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000078",
      "lbl" : "peridermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any squamous epithelial cell that is part of some periderm.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000079",
      "lbl" : "stratified epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell, organized into multiple layers, with only the basal layer being in contact with the basement membrane.",
          "xrefs" : [ "Wikipedia:Epithelium", "doi:/10.1016/B978-0-12-410424-2.00003-2", "https://www.biologyonline.com/dictionary/stratified-epithelium" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000080",
      "lbl" : "circulating cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell which moves among different tissues of the body, via blood, lymph, or other medium.",
          "xrefs" : [ "GOC:add" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000081",
      "lbl" : "blood cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found predominately in the blood.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:62844"
        }, {
          "val" : "MESH:D001773"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000082",
      "lbl" : "epithelial cell of lung",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the lung.",
          "xrefs" : [ "https://orcid.org/0000-0001-5208-3432" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004299"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000083",
      "lbl" : "epithelial cell of pancreas",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the pancreas.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pancreas epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000028"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000084",
      "lbl" : "T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "immature T cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mature T cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000782"
        }, {
          "val" : "CALOHA:TS-1001"
        }, {
          "val" : "FMA:62870"
        }, {
          "val" : "MESH:D013601"
        }, {
          "val" : "VHOG:0001479"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000091",
      "lbl" : "Kupffer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0517223651", "MESH:D007728", "PMID:15771589", "PMID:17105582" ]
        },
        "comments" : [ "Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hepatic macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "littoral cell of hepatic sinusoid"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "macrophagocytus stellatus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "stellate cell of von Kupffer"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "von Kupffer cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000685"
        }, {
          "val" : "FMA:14656"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000092",
      "lbl" : "osteoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. This cell has the following markers: tartrate-resistant acid phosphatase type 5-positive, PU.1-positive, c-fos-positive, nuclear factor NF-kappa-B p100 subunit-positive, tumor necrosis factor receptor superfamily member 11A-positive and macrophage colony-stimulating factor 1 receptor-positive.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:10428500", "PMID:15055519", "PMID:17380158" ]
        },
        "comments" : [ "Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "chondroclast"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000968"
        }, {
          "val" : "CALOHA:TS-0721"
        }, {
          "val" : "FMA:66781"
        }, {
          "val" : "MESH:D010010"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000094",
      "lbl" : "granulocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A leukocyte with abundant granules in the cytoplasm.",
          "xrefs" : [ "GOC:amm", "GOC:tfm", "MESH:D006098", "http://en.wikipedia.org/wiki/Granulocyte" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "granular leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "granular leukocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polymorphonuclear leukocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000539"
        }, {
          "val" : "BTO:0001026"
        }, {
          "val" : "CALOHA:TS-0422"
        }, {
          "val" : "FMA:62854"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000095",
      "lbl" : "neuron associated cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000097",
      "lbl" : "mast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation. Progenitors leave bone marrow and mature in connective and mucosal tissue. Mature mast cells are found in all tissues, except the bloodstream. Their phenotype is CD117-high, CD123-negative, CD193-positive, CD200R3-positive, and FceRI-high. Stem-cell factor (KIT-ligand; SCF) is the main controlling signal of their survival and development.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:068340007X", "MESH:D008407", "PMCID:PMC1312421", "PMCID:PMC2855166", "PMID:15153310", "PMID:16455980", "PMID:19671378", "PMID:212366338", "PMID:9354811" ]
        },
        "comments" : [ "Mast cells are generally integrin beta-7-negative and positive for TLR2, TLR3, TLR4, TLR5, TLR7, TLR9, C3aR, C5aR, CR3, CR4, VEGF, FGF2, and renin. They can express MHC Class I and II on their surface. Activated murine mast cells (IgE+Antigen) were capable of expressing the following co-stimulatory molecules: CD95 (Fas), CD120b, CD137 (4-1BB), CD153 (CD30L), CD154 (CD40L), GITR, ICOSL, OX40L, PD-L1, and PD-L2. Note that there was some mouse strain variation. Mast cells have also been demonstrated to produce bFGF, CCL2, CCL4, CCL5, CCL11, CCL20, CXCL2, CXCL8, CXCL10, GM-CSF, IFN-gamma, IL-1, IL-2, IL-3, IL-8, IL-10, IL-11, IL-12, IL-13, IL-16, IL-25, IL-18, MIP-1, prostaglandin D2, SCF, TGF-beta, TNF-alpha, TSLP, VEGF, and XCL1. They express the transcription factors Transcription factors AP-1, GATA1, MITF, Notch2, PIAS3, PU.1, and STAT5." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "histaminocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "labrocyte",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mastocyte",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tissue basophil",
          "xrefs" : [ "ISBN:068340007X" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000830"
        }, {
          "val" : "CALOHA:TS-0603"
        }, {
          "val" : "FMA:66784"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000098",
      "lbl" : "sensory epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized epithelial cell involved in sensory perception. Restricted to special sense organs of the olfactory, gustatory, and vestibulocochlear receptor systems; contain sensory cells surrounded by supportive, non-receptive cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ]
        },
        "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and neurecto-epithelial cell (CL:0000710)." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "neuroepithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004301"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000099",
      "lbl" : "interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Most generally any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.",
          "xrefs" : [ "GOC:tfm", "MESH:D007395" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "CNS interneuron"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003811"
        }, {
          "val" : "FMA:67313"
        }, {
          "val" : "WBbt:0005113"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000100",
      "lbl" : "motor neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes or inhibits movement.",
          "xrefs" : [ "MESH:D009046", "PMID:16875686" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "motoneuron"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000312"
        }, {
          "val" : "FMA:83617"
        }, {
          "val" : "WBbt:0005409"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000101",
      "lbl" : "sensory neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron having a sensory function; an afferent neuron conveying sensory impulses.",
          "xrefs" : [ "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0001037"
        }, {
          "val" : "FMA:84649"
        }, {
          "val" : "MESH:D011984"
        }, {
          "val" : "WBbt:0005759"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000107",
      "lbl" : "autonomic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron whose cell body is within an autonomic ganglion.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:80121"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000108",
      "lbl" : "cholinergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that uses acetylcholine as a vesicular neurotransmitter.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0004902"
        }, {
          "val" : "FMA:84796"
        }, {
          "val" : "MESH:D059329"
        }, {
          "val" : "WBbt:0006840"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000109",
      "lbl" : "adrenergic neuron",
      "type" : "CLASS",
      "meta" : {
        "xrefs" : [ {
          "val" : "MESH:D059331"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000110",
      "lbl" : "peptidergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that uses neuropeptides as transmitters.",
          "xrefs" : [ "PMID:23040809", "doi:10.1016/B978-012589762-4/50021-9" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000113",
      "lbl" : "mononuclear phagocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A vertebrate phagocyte with a single nucleus.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0001433"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000114",
      "lbl" : "surface ectodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An ectodermal cell that is part of the external ectoderm, forming the outermost layer of the developing embryo. It is characterized by its polarized nature, with distinct apical and basal surfaces (Ferrante Jr., Reinke, & Stanley, 1995). Surface ectodermal cell gives rise to the epidermis, hair follicles, nails, sensory organs, and specialized structures like the apical ectodermal ridge crucial for limb development (Skoufa et al., 2024).",
          "xrefs" : [ "PMID:7892198", "Wikipedia:Surface_ectoderm", "doi:/10.1101/2024.07.02.601324" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell of surface ectoderm"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "surface ectoderm cell",
          "xrefs" : [ "doi:/10.1101/2024.07.02.601324" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:72552"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000115",
      "lbl" : "endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.",
          "xrefs" : [ "GOC:tfm", "MESH:D042783", "PMID:21275341", "http://en.wikipedia.org/wiki/Endothelial_cell", "https://sourceforge.net/tracker/?func=detail&atid=440764&aid=3364936&group_id=36855" ]
        },
        "comments" : [ "From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard]." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "endotheliocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001176"
        }, {
          "val" : "CALOHA:TS-0278"
        }, {
          "val" : "FMA:66772"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000118",
      "lbl" : "basket cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Basket cells are inhibitory GABAergic interneurons of the brain. In general, dendrites of basket cells are free branching and contain smooth spines. Axons are highly branched. The branched axonal arborizations give rise to basket-like structures that surround the soma of the target cell. Basket cells form axo-somatic synapses, meaning their synapses target somas of other cells.",
          "xrefs" : [ "WikipediaVersioned:Basket_cell&oldid=951703880" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000119",
      "lbl" : "cerebellar Golgi cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Large intrinsic neuron located in the granule layer of the cerebellar cortex that extends its dendrites into the molecular layer where they receive contact from parallel fibers. The axon of the Golgi cell ramifies densely in the granule layer and enters into a complex arrangement with mossy fiber terminals and granule cell dendrites to form the cerebellar glomerulus. Llinas, Walton and Lang. In The Synaptic Organization of the Brain. 5th ed. 2004.",
          "xrefs" : [ "NIFSTD:sao1415726815" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Golgi cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Golgi neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cerebellar Golgi neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cerebellum Golgi cell"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D000080906"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000120",
      "lbl" : "granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the vertebrate central nervous system that is small in size. This general class includes small neurons in the granular layer of the cerebellar cortex, cerebral cortex neurons that are not pyramidal cells and small neurons without axons found in the olfactory bulb.",
          "xrefs" : [ "https://medical-dictionary.thefreedictionary.com/granule+cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0003393"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000121",
      "lbl" : "Purkinje cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An inhibitory neuron and the sole output neuron of the cerebellar cortex, the Purkinje cell's soma is located between the granular and molecular layers of the cerebellum. It is one of the largest neural cells in the mammalian brain, ranging from 50 to 80 micrometres in diameter. Purkinje cells have planar, fan-shaped dendrites that branch extensively with little overlap. This cell type receives synaptic input from parallel fibres, which modulate high-frequency spike activity known as \"simple spikes,\" and climbing fibres, which modulate infrequent calcium spike activity known as \"complex spikes\". Purkinje cells are involved in motor coordination, particularly in correcting movements in progress.",
          "xrefs" : [ "MESH:D011689", "PMID:12907269", "PMID:14568361", "PMID:31424738", "PMID:33288911", "PMID:38168772" ]
        },
        "comments" : [ "Neurodegenerative disorders affecting Purkinje cells disrupt motor functions. Some of the neurodegenerative disorders that causes loss and degeration of Purkinje cells are Spinocerebellar ataxias (SCAs) (Josef P Kapfhammer and Etsuko Shimobayashi 2023), Friedreich's ataxia (FRDA) (Kevin C Kemp et al., 2016), Fetal alcohol syndrome (Laurent Servais et al., 2016), Dandy-Walker malformation (Alexander Atamian et al., 2024)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Purkinje neuron",
          "xrefs" : [ "PMID:28821816" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cerebellar Purkinje cell",
          "xrefs" : [ "https://doi.org/10.1016/j.proghi.2004.07.002" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001011"
        }, {
          "val" : "CALOHA:TS-0845"
        }, {
          "val" : "FMA:67969"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000122",
      "lbl" : "stellate neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that has dendritic processes radiating from the cell body forming a star-like shape.",
          "xrefs" : [ "ISBN:9780123973481" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0002316"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000123",
      "lbl" : "neuron associated cell (sensu Vertebrata)",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000125",
      "lbl" : "glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-neuronal cell of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu. Guide neuronal migration during development, and exchange metabolites with neurons.",
          "xrefs" : [ "MESH:D009457" ]
        },
        "comments" : [ "Not all glial cells develop from glioblasts, with microglia developing from the mesoderm instead. See https://github.com/obophenotype/cell-ontology/issues/1571" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuroglial cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "neuroglia"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002606"
        }, {
          "val" : "CALOHA:TS-0415"
        }, {
          "val" : "FMA:54536"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000126",
      "lbl" : "macroglial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroglial cell of ectodermal origin, i.e., the astrocytes and oligodendrocytes considered together.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "macrogliocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000771"
        }, {
          "val" : "CALOHA:TS-2027"
        }, {
          "val" : "FMA:54538"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000127",
      "lbl" : "astrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from 'star' cells) are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier. They regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "MESH:D001253", "PMID:11746784", "PMID:12162730", "PMID:12898703", "PMID:20942978", "http://en.wikipedia.org/wiki/Astrocyte" ]
        },
        "comments" : [ "Astrocytes are reportedly CD68-negative, CD121a-positive, CD184-positive, CD192-positive, CRF-positive, EGFR-positive, GFAP-positive, GLUT1-positive, MBP-negative, and NGFR-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "astrocytic glia"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000099"
        }, {
          "val" : "CALOHA:TS-0060"
        }, {
          "val" : "FMA:54537"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000128",
      "lbl" : "oligodendrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class of large neuroglial (macroglial) cells in the central nervous system. Form the insulating myelin sheath of axons in the central nervous system.",
          "xrefs" : [ "MESH:D009836", "http://en.wikipedia.org/wiki/Oligodendrocyte" ]
        },
        "comments" : [ "Oligodendrocytes are reportedly MDP-positive and CD4-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "OLs",
          "xrefs" : [ "PMID:8734446" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "oligodendroglia"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000962"
        }, {
          "val" : "CALOHA:TS-0709"
        }, {
          "val" : "FMA:54540"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000129",
      "lbl" : "microglial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transcriptomically distinct central nervous system macrophage found in the parenchyma of the central nervous system. Marker include CD11b-positive, F4/80-positive, and CD68-positive.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D017628", "PMID:11517395", "PMID:12430718", "PMID:14561199", "PMID:14612429", "PMID:16177057", "PMID:19461673", "PMID:2089275", "http://en.wikipedia.org/wiki/Microglia" ]
        },
        "comments" : [ "Unlike macroglial cells, microglial cells  arise from hematopoietic stem cells in the yolk sac during early embryogenesis that populate the central nervous system. They derive from embryonic mesoderm and are not from neuroectoderm where glioblast develops from. Markers: Mouse: CD11b+, F4/80+, CD68+. They represent ~12% of the cells in the CNS, but they are not uniformly distributed within the CNS. A normal adult mouse brain has approximately 3.5x10e6 microglia. Microglia are also reportedly CD3-negative, CD4-positive, CD8-negative, CD11b-positive, CD11c-high, CD14-negative, CD19-negative, CD45-low, CD56-negative, CD163-negative, CD200R-positive, CD281-positive, CD282-positive, CD283-positive, CD284-positive, CD285-positive, CD286-positive, CD287-positive, CD288-positive, CD289-positive, Gr1-negative, nestin-positive, and PU.1-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "brain macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brain-resident macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hortega cells",
          "xrefs" : [ "http://www.copewithcytokines.de/" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "microgliocyte",
          "xrefs" : [ "http://www.copewithcytokines.de/" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "MF.microglia.CNS"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000078"
        }, {
          "val" : "BTO:0000962"
        }, {
          "val" : "FMA:54539"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000131",
      "lbl" : "gut endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that lines the blood and lymphatic vessels of the digestive tract. This cell forms the gut–vascular barrier (GVB) through tight junctions and crosstalk with pericytes and enteric glial cells, regulating the passage of nutrients and immune cells while restricting microbial translocation into the bloodstream.",
          "xrefs" : [ "PMID:26564856" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000133",
      "lbl" : "neurectodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Ectoderm destined to be nervous tissue.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neurectoderm cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000134",
      "lbl" : "mesenchymal stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.",
          "xrefs" : [ "FB:ma", "GOC:dsd", "PMCID:PMC2613570", "PMID:10102814", "PMID:16923606", "PMID:17986482", "PMID:19960544", "http://en.wikipedia.org/wiki/Mesenchymal_stem_cell", "http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells" ]
        },
        "comments" : [ "Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "bone marrow stromal cells"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "colony-forming unit-fibroblast"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "marrow stromal cells",
          "xrefs" : [ "PMID:11378515" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mesenchymal precursor cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mesenchymal stem cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mesenchymal stromal cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002625"
        }, {
          "val" : "BTO:0003298"
        }, {
          "val" : "FMA:70546"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000135",
      "lbl" : "circulating fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bone marrow-derived cell that predominantly develops from myeloid lineage-restricted progenitor cells and circulates in peripheral blood, characterized by co-expression of hematopoietic markers CD45 and CD34 along with stromal markers including collagen type I in both humans and mice (Chesney et al., 1997; Blakaj and Bucala, 2012). This spindle-shaped cell exhibits a unique dual identity, functionally bridging immune and stromal compartments with characteristics of both monocytes and fibroblasts. Predominantly arising from circulating monocytes, it migrates to injury sites via chemokine receptors and participates in wound repair through extracellular matrix deposition, cytokine secretion, and antigen presentation via MHC class II. As mesenchymal progenitors, fibrocytes can differentiate into fibroblasts, myofibroblasts, and adipocytes, contributing to both physiological repair and pathological fibrosis (Blakaj and Bucala, 2012).",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:20303382", "PMID:20305780", "PMID:29286323", "PMID:31473260", "PMID:32084275", "PMID:9177213", "doi:/10.1186/1755-1536-5-S1-S6" ]
        },
        "comments" : [ "Cultured human fibrocytes are MHCI-positive, MHCII-positive, CD1a-negative, CD3-negative, CD4-negative, CD8-negative, CD10-negative, CD11b-positive, CD13-positive, CD14-negative, CD16-negative, CD18-positive, CD19-negative, CD25-negative, CD29-positive, CD32-positive, CD33-negative, CD34-positive, CD38-negative, CD40-positive, CD44-negative, CD45RO-positive, CD49a-positive, CD49b-positive, CD49c-negative, CD49d-negative, CD49e-positive, CD49f-negative, CD56-negative, CD58-positive, CD61-positive, CD64-positive, CD70-negative, CD71-positive, CD80-positive, CD83-negative, CD86-positive, CD103-negative, CD105-positive, CD181-positive, CD182-negative, CD183-positive, CD184-positive, CD185-negative, CD186-negative, CD191-positive, CD192-negative, CD193-positive, CD194-positive, CD195-positive, CD196-negative, CD197-positive, CD199-positive, desmin-negative, F4/80-positive, Gr1-positive, LSP-1-positive, MHCI-positive, MHCII-positive, alpha-SMA-negative, TCRab-negative, TCRgd-negative, and vimentin-positive. Fibrocytes are also capable of secreting angiogenin, bFGF, CCL2, CCL3, CCL4, CCL8, CXCL1, type I collagen, type III collagen, CTGF, fibronectin, GM-CSF, IL-1a, IL-6, IL-8, IL-10, M-CSF, MMP-9, PDGF-A, TGF-alpha, TGF-beta1, TNF-alpha, and VEGF-A." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "monocyte-derived fibrocyte",
          "xrefs" : [ "PMID:30826294" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:63879"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000136",
      "lbl" : "adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals. Fat is usually stored in the form of triglycerides.",
          "xrefs" : [ "MESH:D017667" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adipose cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fat cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000443"
        }, {
          "val" : "CALOHA:TS-0012"
        }, {
          "val" : "FMA:63880"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000137",
      "lbl" : "osteocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature osteoblast that has become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.",
          "xrefs" : [ "GOC:tfm", "MESH:D010011" ]
        },
        "comments" : [ "VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "bone cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002038"
        }, {
          "val" : "CALOHA:TS-1167"
        }, {
          "val" : "FMA:66779"
        }, {
          "val" : "VSAO:0000124"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000138",
      "lbl" : "chondrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that is terminally differentiated, secretes an avascular, GAG-rich matrix, is embedded in cartilage tissue matrix, retains the ability to divide, and develops from a chondroblast cell.",
          "xrefs" : [ "GO_REF:0000034", "MESH:D019902" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cartilage cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000249"
        }, {
          "val" : "CALOHA:TS-0138"
        }, {
          "val" : "FMA:66782"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000141",
      "lbl" : "cementocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An osteocytelike cell with numerous processes, trapped in a lacuna in the cement of the tooth.",
          "xrefs" : [ "ISBN:0781733901" ]
        },
        "comments" : [ "CHECK: wikipedia says that cementocytes no longer produce cementum, but the phenoscape def is: Skeletogenic cell that produces cementum, is part of the odontogenic papilla, and is a transformation of a cementoblast cell (no change to existing def)." ],
        "xrefs" : [ {
          "val" : "FMA:63003"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000145",
      "lbl" : "professional antigen presenting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note change of name; nearly all somatic cells can present antigens to T cells via MHC Class I complexes leading to effector responses, but professional antigen presenting cells constitutively express MHC Class II as well as costimulatory molecules, and thus can initiate immune responses via T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000146",
      "lbl" : "simple columnar epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000147",
      "lbl" : "pigment cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pigment cell is a cell that contains pigment granules.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chromatocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "chromatophore"
        } ],
        "xrefs" : [ {
          "val" : "VHOG:0001678"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000148",
      "lbl" : "melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pigment cell derived from the neural crest. Contains melanin-filled pigment granules, which gives a brown to black appearance.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "melanophore"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000847"
        }, {
          "val" : "CALOHA:TS-0613"
        }, {
          "val" : "FMA:70545"
        }, {
          "val" : "MESH:D008544"
        }, {
          "val" : "VHOG:0001679"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000149",
      "lbl" : "visual pigment cell",
      "type" : "CLASS",
      "meta" : {
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "pigment cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000150",
      "lbl" : "glandular secretory epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell, located in a gland, that is specialised for the synthesis and secretion of specific biomolecules, such as hormones, or mucous.",
          "xrefs" : [ "GOC:tfm", "ORCID:0000-0002-7073-9172" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glandular epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2085"
        }, {
          "val" : "FMA:86494"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000151",
      "lbl" : "secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that specializes in controlled release of one or more substances.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0003659"
        }, {
          "val" : "FMA:86916"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000152",
      "lbl" : "exocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of an exocrine gland; i.e. a gland that discharges its secretion via a duct.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:16014"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000153",
      "lbl" : "glycosaminoglycan secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that secretes glycosaminoglycans.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GAG secreting cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "hyaluronic acid secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000154",
      "lbl" : "protein secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some protein secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000155",
      "lbl" : "peptic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by a basally located nucleus, abundant rough endoplasmic reticulum, and large apical secretory granules. It produces and secretes pepsinogen, the inactive precursor of the digestive enzyme pepsin.",
          "xrefs" : [ "GOC:tfm", "PMID:21907708", "PMID:30571046", "Wikipedia:Gastric_chief_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chief cell of stomach"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gastric chief cell",
          "xrefs" : [ "Wikipedia:Chief_cell" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pepsinogen secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "zymogenic cell",
          "xrefs" : [ "Wikipedia:Chief_cell" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:62902"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000157",
      "lbl" : "surfactant secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that specializes in secretion of surfactant in the alveoli of the lung.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000158",
      "lbl" : "club cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-mucous, epithelial secretory cell that is part of the tracheobronchial tree. A club cell has short microvilli but no cilia. A club cell is able to multiply and differentiate into ciliated cells to regenerate the bronchiolar epithelium and it also protects the tracheobronchial epithelium.",
          "xrefs" : [ "DOI:10.1183/09031936.00146609", "DOI:10.1378/chest.12-2762", "GOC:tfm", "PMID:28128362", "PMID:29874100", "PMID:7905712" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Clara cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004811"
        }, {
          "val" : "FMA:14119"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000159",
      "lbl" : "seromucus secreting cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000160",
      "lbl" : "goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized, columnar, mucus secreting epithelial cell shaped like a flask or goblet. A narrow basal end contains the nucleus while the apical end is swollen by the accumulation of mucus laden secretory granules.  Short microvilli project from the apical plasma membrane.",
          "xrefs" : [ "MESH:D020397", "http://en.wikipedia.org/wiki/Goblet_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chalice cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001540"
        }, {
          "val" : "FMA:13148"
        }, {
          "val" : "http://en.wikipedia.org/wiki/Goblet_cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000162",
      "lbl" : "parietal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the stomach that is part of the fundic gastric gland. This cell is characterized by its pyramidal shape, abundant mitochondria, and a complex network of secretory canaliculi lined with microvilli. It secretes hydrochloric acid into the stomach lumen and produces intrinsic factor, essential for vitamin B12 absorption.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:31613538", "PMID:31670611" ]
        },
        "comments" : [ "Parietal cells have dynamic, actin-supported microvilli that increase in number during active secretion, playing a crucial role in secreting hydrochloric acid and intrinsic factor. The structure and regulation of these microvilli are influenced by proteins such as ASAP3, which modulates Arf6 activity and actin assembly, thereby controlling microvilli formation and parietal cell function." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gastric parietal cell",
          "xrefs" : [ "PMID:29263912" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "oxyntic cell",
          "xrefs" : [ "Wikipedia:Parietal_cell" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001780"
        }, {
          "val" : "FMA:62901"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000163",
      "lbl" : "endocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of an endocrine gland, ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.",
          "xrefs" : [ "MESH:D055098" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "endocrinocyte"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83809"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000164",
      "lbl" : "enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endocrine cell that is located in the epithelium of the gastrointestinal tract or in the pancreas.",
          "xrefs" : [ "GOC:tfm", "SANBI:mhl" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0003865"
        }, {
          "val" : "FMA:62930"
        }, {
          "val" : "MESH:D019858"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000165",
      "lbl" : "neuroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that is capable of some hormone secretion in response to neuronal signals.",
          "xrefs" : [ "MESH:D055099" ]
        },
        "comments" : [ "The neurosecretory cell is neither an ordinary neuron nor an endocrine cell, but a combination of both. Its neuronal features resemble those of ordinary neurons concerning both structure and function. The production of a visible secretory material marks the neurosecretory neuron as a gland cell, and the fact that extractable cellular products act in the manner of hormones places it in the realm of endocrine elements. \n\nThe modern definition of neurosecretion has evolved to include the release of any neuronal secretory product from a neuron." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "neurosecretory cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "neurosecretory neuron"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002691"
        }, {
          "val" : "FMA:83810"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000166",
      "lbl" : "chromaffin cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that stores epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system.",
          "xrefs" : [ "MESH:D019439" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "phaeochromocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000259"
        }, {
          "val" : "FMA:69263"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000167",
      "lbl" : "peptide hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some peptide hormone secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000168",
      "lbl" : "insulin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some insulin secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0000783"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000169",
      "lbl" : "type B pancreatic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that secretes insulin and is located towards the center of the islets of Langerhans.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Pancreatic_b_cell" ]
        },
        "comments" : [ "Pancreatic beta cells are also reportedly CD284-positive. Upon activation, they upregulate their CD14 expression." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "beta cell",
          "xrefs" : [ "ZFA:0009102" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell of pancreatic islet",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "beta cell of pancreatic islet",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "insulin-secreting cell",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic B-cell",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic beta cell",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic islet core",
          "xrefs" : [ "MA:0002419" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type B enteroendocrine cell",
          "xrefs" : [ "FMA:70586" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "beta cell islet",
          "xrefs" : [ "MA:0002419" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000783"
        }, {
          "val" : "EV:0200009"
        }, {
          "val" : "FMA:70586"
        }, {
          "val" : "MA:0002419"
        }, {
          "val" : "ncithesaurus:Beta_Cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000170",
      "lbl" : "glucagon secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that secretes glucagon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glucagon-secreting cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84045"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000171",
      "lbl" : "pancreatic A cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type A enteroendocrine cell found in the periphery of the islets of Langerhans that secretes glucagon.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alpha cell of islet of Langerhans"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic alpha cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000990"
        }, {
          "val" : "FMA:70585"
        }, {
          "val" : "MESH:D050416"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000172",
      "lbl" : "somatostatin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some somatostatin secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000173",
      "lbl" : "pancreatic D cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A D cell located in the pancreas. Peripherally placed within the islets like type A cells; contains somatostatin.",
          "xrefs" : [ "FMA:0517223651", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "D-cell of pancreatic islet"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "delta cell of islet"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "delta cell of pancreatic islet"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic D-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic delta cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "somatostatin-secreting pancreatic cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000803"
        }, {
          "val" : "FMA:70587"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000174",
      "lbl" : "steroid hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some steroid hormone secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000175",
      "lbl" : "luteal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progesterone secreting cell in the corpus luteum. The large luteal cells develop from the granulosa cells. The small luteal cells develop from the theca cells.",
          "xrefs" : [ "MESH:D008184", "PMID:31849844" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "corpus luteum cell",
          "xrefs" : [ "PMID:16790079" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lutein cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003939"
        }, {
          "val" : "FMA:18688"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000177",
      "lbl" : "testosterone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some testosterone secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000178",
      "lbl" : "Leydig cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Leydig cell is a testosterone-secreting cell in the interstitial area, between the seminiferous tubules, in the testis.",
          "xrefs" : [ "GOC:tfm", "PMID:12050120" ]
        },
        "comments" : [ "Note that the Amphibian Anatomy Ontology (AA) has a class 'leydig cells' but this is unrelated" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "interstitial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "interstitial cell of Leydig"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000755"
        }, {
          "val" : "CALOHA:TS-1150"
        }, {
          "val" : "EMAPA:29655"
        }, {
          "val" : "FMA:72297"
        }, {
          "val" : "MESH:D007985"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000179",
      "lbl" : "progesterone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some progesterone secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000182",
      "lbl" : "hepatocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The main structural component of the liver. They are specialized epithelial cells that are organized into interconnected plates called lobules. Majority of cell population of liver, polygonal in shape, arranged in plates or trabeculae between sinusoids; may have single nucleus or binucleated.",
          "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "MESH:D022781", "PMID:19717280", "http://en.wikipedia.org/wiki/Hepatocyte" ]
        },
        "comments" : [ "Hepatocytes are reportedly MHC Class I-positive and MHC Class II-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000575"
        }, {
          "val" : "CALOHA:TS-0454"
        }, {
          "val" : "FMA:14515"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000183",
      "lbl" : "contractile cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell whose primary function is to shorten.",
          "xrefs" : [ "FB:ma" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000185",
      "lbl" : "myoepithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Contractile cells resembling smooth muscle cells that are present in glands, notably the mammary gland, and aid in secretion. This cell has long weaving dendritic processes containing myofilament.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basket epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myoepitheliocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002309"
        }, {
          "val" : "CALOHA:TS-2379"
        }, {
          "val" : "FMA:67799"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000187",
      "lbl" : "muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.",
          "xrefs" : [ "MESH:D032342" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "muscle fiber"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000888"
        }, {
          "val" : "BTO:0000902"
        }, {
          "val" : "CALOHA:TS-2032"
        }, {
          "val" : "FMA:67328"
        }, {
          "val" : "WBbt:0003675"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000188",
      "lbl" : "cell of skeletal muscle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A somatic cell located in skeletal muscle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "skeletal muscle cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004392"
        }, {
          "val" : "CALOHA:TS-2158"
        }, {
          "val" : "FMA:9727"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000192",
      "lbl" : "smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-striated, elongated, spindle-shaped cell found lining the digestive tract, uterus, and blood vessels. They develop from specialized myoblasts (smooth muscle myoblast).",
          "xrefs" : [ "MESH:D032389", "PMID:9315361", "http://en.wikipedia.org/wiki/Smooth_muscle_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "non-striated muscle cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SMCs",
          "xrefs" : [ "PMID:9315361" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myocytes, smooth muscle",
          "xrefs" : [ "MESH:D032389" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle fiber"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004576"
        }, {
          "val" : "CALOHA:TS-2159"
        }, {
          "val" : "FMA:14072"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000197",
      "lbl" : "sensory receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is capable of detection of a stimulus involved in sensory perception."
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "receptor cell"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D011984"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000198",
      "lbl" : "pain receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The peripheral receptor for pain. Includes receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All mammalian nociceptors are free nerve endings.",
          "xrefs" : [ "MESH:D009619" ]
        },
        "comments" : [ "Editor note: request detection of stimulus involved in sensory perception of pain; add develops_from relationship" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000199",
      "lbl" : "mechanoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system.",
          "xrefs" : [ "MESH:D008465" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "mechanoreceptor",
          "xrefs" : [ "MP:0000972" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000200",
      "lbl" : "touch receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that is capable of some detection of mechanical stimulus involved in sensory perception of touch.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000202",
      "lbl" : "auditory hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mechanoreceptor cell of the auditory or vestibular system that is sensitive to auditory stimuli. The accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system.",
          "xrefs" : [ "MESH:D006198", "WikipediaVersioned:Hair_cell&oldid=1045345915" ]
        },
        "comments" : [ "In mammals these cells are located in the organ of Corti." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "auditory receptor cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000203",
      "lbl" : "gravity sensitive cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuronal receptor cell that is capable of some detection of mechanical stimulus involved in sensory perception.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000205",
      "lbl" : "thermoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cellular receptor which mediates the sense of temperature. Thermoreceptor cells in vertebrates are mostly located under the skin. In mammals there are separate types of thermoreceptors for cold and for warmth and pain receptor cells which detect cold or heat extreme enough to cause pain.",
          "xrefs" : [ "GOC:tfm", "MESH:D013823", "MP:0000971" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000206",
      "lbl" : "chemoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell specialized to detect chemical substances and relay that information centrally in the nervous system. Chemoreceptors may monitor external stimuli, as in taste and olfaction, or internal stimuli, such as the concentrations of oxygen and carbon dioxide in the blood.",
          "xrefs" : [ "MESH:D002628" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000207",
      "lbl" : "olfactory receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that is capable of some detection of chemical stimulus involved in sensory perception of smell.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Schultze's cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "odorant receptor cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory receptor neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory sensory neuron"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004185"
        }, {
          "val" : "FMA:67860"
        }, {
          "val" : "MESH:D018034"
        }, {
          "val" : "Wikipedia:Olfactory_receptor_neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000209",
      "lbl" : "taste receptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized cell involved in gustatory sensory perception.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "taste bud cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:67910"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000210",
      "lbl" : "photoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell specialized in detecting light stimuli that are involved in visual perception.",
          "xrefs" : [ "MESH:D010786" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001060"
        }, {
          "val" : "CALOHA:TS-0868"
        }, {
          "val" : "FMA:86740"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000211",
      "lbl" : "electrically active cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell whose function is determined by the generation or the reception of an electric signal.",
          "xrefs" : [ "FB:ma" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000214",
      "lbl" : "synovial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell located in the synovial joint."
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "synoviocyte"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0995"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000216",
      "lbl" : "Sertoli cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supporting cell projecting inward from the basement membrane of seminiferous tubules. They surround and nourish the developing male germ cells and secrete androgen binding protein. Their tight junctions with the spermatogonia and spermatocytes provide a blood-testis barrier.",
          "xrefs" : [ "MESH:D012708" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001238"
        }, {
          "val" : "CALOHA:TS-0922"
        }, {
          "val" : "FMA:72298"
        }, {
          "val" : "VHOG:0001348"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000218",
      "lbl" : "myelinating Schwann cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroglial cell of the peripheral nervous system which forms the insulating myelin sheaths of peripheral axons.",
          "xrefs" : [ "GOC:cvs", "GOC:tfm", "MESH:D012583" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Schwann cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "peripheral neuroglial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neurilemmal cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0898"
        }, {
          "val" : "FMA:62121"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000219",
      "lbl" : "motile cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that moves by its own activities.",
          "xrefs" : [ "FB:ma" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000221",
      "lbl" : "ectodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the outer of the three germ layers of the embryo.",
          "xrefs" : [ "MESH:D004475" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ectoderm cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:72549"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000222",
      "lbl" : "mesodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the middle germ layer of the embryo.",
          "xrefs" : [ "MESH:D008648" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mesoblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mesoderm cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:72554"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000223",
      "lbl" : "endodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the inner of the three germ layers of the embryo.",
          "xrefs" : [ "MESH:D004707" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "endoderm cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:72555"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000225",
      "lbl" : "anucleate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that lacks a nucleus.",
          "xrefs" : [ "FB:ma" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-nucleated cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:68647"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000226",
      "lbl" : "single nucleate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell with a single nucleus.",
          "xrefs" : [ "FB:ma", "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000228",
      "lbl" : "multinucleate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell with more than one nucleus.",
          "xrefs" : [ "FB:ma", "Wikipedia:Multinucleate" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "multinucleated cells",
          "xrefs" : [ "Wikipedia:Multinucleate" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polynuclear cells",
          "xrefs" : [ "Wikipedia:Multinucleate" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000232",
      "lbl" : "erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A red blood cell. In mammals, mature erythrocytes are biconcave disks containing hemoglobin whose function is to transport oxygen.",
          "xrefs" : [ "GOC:tfm", "MESH:D004912" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "RBC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "red blood cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000424"
        }, {
          "val" : "CALOHA:TS-0290"
        }, {
          "val" : "FMA:81100"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000233",
      "lbl" : "platelet",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "MESH:D001792", "PMID:11110672", "PMID:16987572", "PMID:17204662", "PMID:17479180", "PMID:20414831", "http://en.wikipedia.org/wiki/Platelet" ]
        },
        "comments" : [ "Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anucleate thrombocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "blood platelet"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "enucleate thrombocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000132"
        }, {
          "val" : "CALOHA:TS-0803"
        }, {
          "val" : "FMA:62851"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000234",
      "lbl" : "phagocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell capable of ingesting particulate matter via phagocytosis.",
          "xrefs" : [ "GOC:add", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001044"
        }, {
          "val" : "FMA:83806"
        }, {
          "val" : "MESH:D010586"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000235",
      "lbl" : "macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:16213494", "PMID:1919437" ]
        },
        "comments" : [ "Morphology: Diameter 30_M-80 _M, abundant cytoplasm, low N/C ratio, eccentric nucleus. Irregular shape with pseudopods, highly adhesive. Contain vacuoles and phagosomes, may contain azurophilic granules; markers: Mouse & Human: CD68, in most cases CD11b. Mouse: in most cases F4/80+; role or process: immune, antigen presentation, & tissue remodelling; lineage: hematopoietic, myeloid." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "histiocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000801"
        }, {
          "val" : "CALOHA:TS-0587"
        }, {
          "val" : "FMA:63261"
        }, {
          "val" : "FMA:83585"
        }, {
          "val" : "MESH:D008264"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000236",
      "lbl" : "B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte of B lineage that is capable of B cell mediated immunity.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000776"
        }, {
          "val" : "CALOHA:TS-0068"
        }, {
          "val" : "FMA:62869"
        }, {
          "val" : "MESH:D001402"
        }, {
          "val" : "VHOG:0001480"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000237",
      "lbl" : "keratinizing barrier epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000239",
      "lbl" : "brush border epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell characterized by the presence of a brush border on its apical surface, which increases the surface area for absorption."
        },
        "comments" : [ "All brush border cells are columnar-cuboidal.  The formal logical definition of this term asserts this. Brush border epithelial cells are predominantly found lining the small intestine and the proximal tubules of the kidneys." ],
        "xrefs" : [ {
          "val" : "PMID:25422372"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasDbXref",
          "val" : "https://doi.org/10.1152/ajpgi.00005.2011"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000240",
      "lbl" : "stratified squamous epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stratified epithelial cell that is part of squamous epithelium, characterized by multiple layers of cells. The basal layer is directly attached to the basement membrane and the apical layer consists of flattened squamous cells. This provides a protective barrier, commonly found in areas subject to abrasion, such as the skin, oral cavity, and esophagus.",
          "xrefs" : [ "PMID:30422572", "Wikipedia:Epithelium", "Wikipedia:Stratified_squamous_epithelium" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000241",
      "lbl" : "stratified cuboidal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stratified epithelial cell that is part of cuboidal epithelium, characterized by multiple layers of cuboidal cells forming the apical layer. This provides a protective lining for ducts in large glands, such as sweat glands.",
          "xrefs" : [ "PMID:30422572", "Wikipedia:Stratified_cuboidal_epithelium" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000242",
      "lbl" : "Merkel cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized epithelial cell located in the skin epidermis and certain mucosal epithelia. It functions as a mechanoreceptor for light touch by forming synapse-like contacts with somatosensory afferent nerve endings, contributing to slowly adapting type I (SAI) tactile responses. Characterized by dense-core neuroendocrine granules, the Merkel cell exhibits both sensory and neuroendocrine properties, including regulated neurotransmitter release via SNARE complex-dependent mechanisms. Its development in mice depends on the transcription factor Atoh1.",
          "xrefs" : [ "MESH:D018862", "PMID:19834574", "PMID:2274847", "PMID:24862916", "PMID:30415995", "Wikipedia:Merkel_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Merkel's cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70548"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000244",
      "lbl" : "transitional epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell characteristically found lining hollow organs that are subject to great mechanical change due to contraction and distention; originally thought to represent a transition between stratified squamous and columnar epithelium.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:66778"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000255",
      "lbl" : "eukaryotic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that in taxon some Eukaryota.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "MESH:D005057"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000287",
      "lbl" : "eye photoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any photoreceptor cell that is part of some eye.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000295",
      "lbl" : "somatotropin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell that produces growth hormone, somatotropin.",
          "xrefs" : [ "GOC:tfm", "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "growth hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "somatotrophin secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000300",
      "lbl" : "gamete",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature sexual reproductive cell having a single set of unpaired chromosomes.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "haploid nucleated cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "haploid germ cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0395"
        }, {
          "val" : "FMA:18649"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000306",
      "lbl" : "crystallin accumulating cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lens cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000307",
      "lbl" : "tracheal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell found in the trachea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "This class is for the vertebrate tracheal structure. For the analagous insect cell type, see 'respiratory tube epithelial cell'" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "tracheocyte"
        } ],
        "xrefs" : [ {
          "val" : "FMA:74793"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000311",
      "lbl" : "keratin accumulating cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000312",
      "lbl" : "keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of stratified squamous tissues, including skin, oral mucosa (Hiroshima et al., 2011), and esophagus (Whelan et al., 2018), that produces keratin proteins and secretes antimicrobial peptides to form a resilient barrier against environmental damage, dehydration, pathogens, and microbial invasion. It undergoes successive stages of differentiation marked by changes in keratin expression, supporting tissue integrity, wound repair, and contributing to immune defense.",
          "xrefs" : [ "PMID:15749908", "PMID:19256306", "PMID:19727116", "PMID:29713660", "PMID:37873034" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000667"
        }, {
          "val" : "CALOHA:TS-0500"
        }, {
          "val" : "FMA:62879"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000313",
      "lbl" : "serous secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Columnar glandular cell with irregular nucleus, copious granular endoplasmic reticulum and supranuclear granules. Secretes a watery fluid containing proteins known as serous fluid.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "serous cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003687"
        }, {
          "val" : "FMA:62511"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000314",
      "lbl" : "milk secreting cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000317",
      "lbl" : "sebocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of a sebaceous gland. This cell produces and secretes sebum, an oily, lipid-rich substance, through holocrine secretion where the entire cell ruptures to release its contents.",
          "xrefs" : [ "MESH:D012629", "PMID:19944183" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "sebum secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000319",
      "lbl" : "mucus secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is capable of some mucus secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mucous cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003689"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000322",
      "lbl" : "pulmonary alveolar epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that lines the peripheral gas exchange region of the lungs of air-breathing vertebrates.",
          "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alveolar epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alveolus of lung epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of alveolus of lung"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pneumocyte",
          "xrefs" : [ "PMID:32491474" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pneumonocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000395"
        }, {
          "val" : "CALOHA:TS-2168"
        }, {
          "val" : "FMA:62499"
        }, {
          "val" : "MESH:D056809"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-6677-8489"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-02T08:27:21Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000323",
      "lbl" : "lysozyme secreting cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000325",
      "lbl" : "stuff accumulating cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is specialised to accumulate a particular substance(s).",
          "xrefs" : [ "FB:ma" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/ubprop#_upper_level" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000326",
      "lbl" : "glycogen accumulating cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000327",
      "lbl" : "extracellular matrix secreting cell",
      "type" : "CLASS",
      "meta" : {
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000329",
      "lbl" : "oxygen accumulating cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is capable of some oxygen transport.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000333",
      "lbl" : "migratory neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell derived from the specialized ectoderm flanking each side of the embryonic neural plate, which after the closure of the neural tube, forms masses of cells that migrate out from the dorsal aspect of the neural tube to spread throughout the body.",
          "xrefs" : [ "doi:10.1016/j.stem.2015.02.017" ]
        },
        "xrefs" : [ {
          "val" : "FMA:86667"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000335",
      "lbl" : "mesenchyme condensation cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesenchymal cell in embryonic development found in a contracting mass and that gives rise to osteoprogenitors.",
          "xrefs" : [ "GOC:tfm", "PMID:5025404" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000336",
      "lbl" : "adrenal medulla chromaffin cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found within the adrenal medulla that secrete biogenic amine hormones upon stimulation.",
          "xrefs" : [ "GOC:tfm", "http://www.britannica.com/EBchecked/topic/6405/adrenal-gland" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "medullary chromaffin cell of adrenal gland",
          "xrefs" : [ "FMA:69262" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:69262"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000337",
      "type" : "CLASS",
      "meta" : {
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0100001",
          "val" : "http://purl.obolibrary.org/obo/CL_0000031"
        } ],
        "deprecated" : true
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000339",
      "lbl" : "glioblast (sensu Vertebrata)",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An early neural cell developing from the early ependymal cell of the neural tube.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "spongioblast"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70564"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000346",
      "lbl" : "hair follicle dermal papilla cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized fibroblast that resides in the dermal papilla located at the bottom of hair follicles. This cell orchestrates reciprocal epithelial-mesenchymal signaling essential for hair follicle morphogenesis and cycling, regulating matrix cell proliferation and differentiation to control hair shaft size, shape, and growth. The dermal papilla cell is replenished each hair cycle from bipotent hair follicle dermal stem cells in the dermal sheath that simultaneously self-renew and contribute progeny to the papilla, particularly during anagen.",
          "xrefs" : [ "PMID:28418596", "PMID:39798934", "PMID:40867641" ]
        },
        "comments" : [ "The dermal papilla contains functionally heterogeneous Sox2-positive subpopulations that serve as a niche for multipotent stem cells. These cells exhibit progenitor properties, generate skin-derived precursors (SKPs), and can differentiate into adipogenic and osteogenic lineages." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000347",
      "lbl" : "scleral cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the sclera of the eye.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000348",
      "lbl" : "choroidal cell of the eye",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of optic choroid.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000349",
      "lbl" : "extraembryonic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some extraembryonic structure.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000351",
      "lbl" : "trophoblast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An extraembryonic cell that develops from a trophectodermal cell. This cell is found in the outer layer of the blastocyst and can invade other structures in the uterus once the blastocyst implants into the uterine wall. A trophoblast cell is involved in the implantation of the embryo into the uterine wall, placental formation, remodelling of maternal vasculature in the uterus, nutrient and gas exchange, hormone production, and immune modulation to support fetal development.",
          "xrefs" : [ "GOC:tfm", "MESH:D014327", "PMID:37630754", "doi:10.1007/978-3-030-84725-8" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "trophoblastic cell",
          "xrefs" : [ "doi:10.1007/978-3-030-84725-8" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:83028"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000352",
      "lbl" : "epiblast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the outer layer of a blastula that gives rise to the ectoderm after gastrulation.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000353",
      "lbl" : "blastoderm cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An undifferentiated cell produced by early cleavages of the fertilized egg (zygote).",
          "xrefs" : [ "MESH:D001756" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "blastomere"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001473"
        }, {
          "val" : "FMA:72551"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000354",
      "lbl" : "blastemal cell",
      "type" : "CLASS",
      "meta" : {
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "blastema cell"
        } ],
        "xrefs" : [ {
          "val" : "ncithesaurus:Blastemal_Cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000355",
      "lbl" : "multi-potent skeletal muscle stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multifate stem cell found in skeletal muscle than can differentiate into many different cell types, including muscle. Distinct cell type from satellite cell.",
          "xrefs" : [ "PMID:18282570" ]
        },
        "comments" : [ "Multi-potency demonstrated ex vivo.  At the time of writing, it is unclear whether the endogenous population differentiates into multiple cell types in vivo." ],
        "xrefs" : [ {
          "val" : "FMA:86767"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000357",
      "lbl" : "stratified epithelial stem cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000358",
      "lbl" : "sphincter associated smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of a sphincter. A sphincter is a typically circular muscle that normally maintains constriction of a natural body passage or orifice and which relaxes as required by normal physiological functioning.",
          "xrefs" : [ "GOC:cjm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000359",
      "lbl" : "vascular associated smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell associated with the vasculature.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "VSMC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "vascular smooth muscle cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000362",
      "lbl" : "epidermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the integument (the outer layer of an organism).",
          "xrefs" : [ "Flybase:dsj", "MA:ma" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell of epidermis",
          "xrefs" : [ "FMA:62411" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "epithelial cell of skin",
          "xrefs" : [ "FMA:62411" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001470"
        }, {
          "val" : "CALOHA:TS-0283"
        }, {
          "val" : "FMA:62411"
        }, {
          "val" : "MESH:D000078404"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000365",
      "lbl" : "animal zygote",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Diploid cell produced by the fusion of sperm cell nucleus and egg cell.",
          "xrefs" : [ "ISBN:0471245208" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "zygote"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000854"
        }, {
          "val" : "EHDAA2:0004546"
        }, {
          "val" : "FMA:72395"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000377",
      "lbl" : "tracheoblast",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000388",
      "lbl" : "tendon cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An elongated fibroblast that is part of a tendon. Its cytoplasm is stretched between the collagen fibres of the tendon, and it possesses a central nucleus with a prominent nucleolus. Tendon cell has a well-developed rough endoplasmic reticulum, and it is responsible for the synthesis and turnover of tendon fibres and ground substance.",
          "xrefs" : [ "GOC:NV", "GOC:tfm", "PMID:37894875", "PMID:957445" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "muscle attachment cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tenocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000393",
      "lbl" : "electrically responsive cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell whose function is determined by its response to an electric signal.",
          "xrefs" : [ "FB:ma" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000397",
      "lbl" : "ganglion interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any interneuron that has its soma located in some ganglion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000404",
      "lbl" : "electrically signaling cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that initiates an electrical signal and passes that signal to another cell.",
          "xrefs" : [ "FB:ma" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000408",
      "lbl" : "male gamete",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any male germ cell that has characteristic some haploid and is capable of some fertilization.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0001277"
        }, {
          "val" : "CALOHA:TS-0949"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000412",
      "lbl" : "polyploid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that contains more than two haploid sets of chromosomes.",
          "xrefs" : [ "FB:ma", "PMID:32646579", "https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.04%3A_Polyploidy" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000413",
      "lbl" : "haploid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell whose nucleus contains a single haploid genome.",
          "xrefs" : [ "FB:ma", "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000417",
      "lbl" : "endopolyploid cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000424",
      "lbl" : "excretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell involved in the elimination of metabolic and foreign toxins, and in maintaining the ionic, acid-base and water balance of biological fluids.",
          "xrefs" : [ "GOC:tfm", "PMID:19783135" ]
        },
        "xrefs" : [ {
          "val" : "WBbt:0005812"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000432",
      "lbl" : "reticular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Reticular_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "reticulum cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62877"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000437",
      "lbl" : "gonadtroph",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rounded cell that is usually situated next to sinusoids; secretes follicular stimulating hormone (FSH) and luteinizing hormone (LH).",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "http://en.wikipedia.org/wiki/Gonadotroph" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "delta basophil"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "follicle stimulating hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gonadotrope"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gonadotrope cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gonadotroph"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gonadotropic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pituitary delta cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002482"
        }, {
          "val" : "FMA:83100"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000438",
      "lbl" : "luteinizing hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell pituitary that produces luteinizing hormone.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000439",
      "lbl" : "prolactin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone cell that secretes prolactin.",
          "xrefs" : [ "GOC:tfm", "SANBI:mhl" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000440",
      "lbl" : "melanocyte stimulating hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the intermediate pituitary that produces melanocyte stimulating hormone.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "melanotrope"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "melanotroph"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002277"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000442",
      "lbl" : "follicular dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue. They are unrelated to the dendritic cell associated with T cells. Follicular dendritic cells have Fc receptors and C3b receptors, but unlike other dendritic cells, they do not process or present antigen in a way that allows recognition by T cells. Instead, they hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response.",
          "xrefs" : [ "ISBN:127520252" ]
        },
        "comments" : [ "Due to its unique lineage and distinct function, this is not a type of dendritic cell; CL:0000451." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0004267"
        }, {
          "val" : "FMA:83037"
        }, {
          "val" : "MESH:D020566"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000443",
      "lbl" : "calcitonin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some calcitonin secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000446",
      "lbl" : "chief cell of parathyroid gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the parathyroid gland that is arranged in wide, irregular interconnecting columns; responsible for the synthesis and secretion of parathyroid hormone.",
          "xrefs" : [ "FMA:69078", "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "parathyroid chief cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "parathyroid gland chief cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "parathyroid hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "principal cell of parathyroid gland"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004712"
        }, {
          "val" : "CALOHA:TS-2140"
        }, {
          "val" : "FMA:69078"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000447",
      "lbl" : "carbohydrate secreting cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000448",
      "lbl" : "white adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte with light coloration and few mitochondria. It contains a scant ring of cytoplasm surrounding a single large lipid droplet or vacuole.",
          "xrefs" : [ "GOC:tfm", "MESH:D052438" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "white adipose cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "white fat cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1119"
        }, {
          "val" : "FMA:83434"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000449",
      "lbl" : "brown adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell from the thermogenic form of adipose tissue found in many species,  particularly in newborns and hibernating mammals, but also in lesser amounts in adults of other mammals including humans. Brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation.",
          "xrefs" : [ "MESH:D002001" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "brown adipose cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brown fat cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0099"
        }, {
          "val" : "FMA:83435"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000451",
      "lbl" : "dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation. These cells are lineage negative (CD3-negative, CD19-negative, CD34-negative, and CD56-negative).",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "interdigitating cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "veiled cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002042"
        }, {
          "val" : "CALOHA:TS-0194"
        }, {
          "val" : "FMA:83036"
        }, {
          "val" : "MESH:D003713"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000452",
      "lbl" : "obsolete thyroid hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "This term is redundant and has been merged with thyroid follicular cell" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/obophenotype/cell-ontology/issues/3161"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0100001",
          "val" : "http://purl.obolibrary.org/obo/CL_0002258"
        } ],
        "deprecated" : true
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000453",
      "lbl" : "Langerhans cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149", "PMCID:PMC2346585", "PMID:17850486" ]
        },
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "LC"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000705"
        }, {
          "val" : "CALOHA:TS-2375"
        }, {
          "val" : "FMA:63072"
        }, {
          "val" : "MESH:D007801"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000454",
      "lbl" : "epinephrine secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell capable of producing epinephrine. Epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme, which is expressed in the adrenal glands, androgenic neurons, and in other cell types.",
          "xrefs" : [ "GOC:tfm", "PMID:12438093" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adrenaline secreting cell",
          "xrefs" : [ "GO:0048242" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epinephrin secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000456",
      "lbl" : "mineralocorticoid secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some mineralocorticoid secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000457",
      "lbl" : "biogenic amine secreting cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000458",
      "lbl" : "serotonin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell type that secretes 5-Hydroxytryptamine (serotonin).",
          "xrefs" : [ "GOC:tfm", "PMID:19630576" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "5-HT secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "5-Hydroxytryptamine secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000459",
      "lbl" : "noradrenergic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell capable of producting norepiniphrine. Norepiniphrine is a catecholamine with multiple roles including as a hormone and a neurotransmitter. In addition, epiniphrine is synthesized from norepiniphrine by the actions of the phenylethanolamine N-methyltransferase enzyme.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "noradrenaline secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "norepinephrin secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "norepinephrine secreting cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000460",
      "lbl" : "glucocorticoid secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is capable of some glucocorticoid secretion.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000467",
      "lbl" : "adrenocorticotropic hormone secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell that produces adrenocorticotropin, or corticotropin.",
          "xrefs" : [ "GOC:tfm", "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ACTH secreting cell",
          "xrefs" : [ "GO:0051458" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adrenocorticotrophic hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "corticotrophin hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "corticotropin hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "corticotropin secreting cell",
          "xrefs" : [ "GO:0051458" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000476",
      "lbl" : "thyrotroph",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basophil cell of the anterior pituitary that produces thyroid stimulating hormone, thyrotrophin. This cell type is elongated, polygonal and lie in clusters towards the adenohypophyseal center.",
          "xrefs" : [ "ISBN:0517223651", "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "beta-basophil"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "thyroid stimulating hormone secreting cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "thyrotrope"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83099"
        }, {
          "val" : "MESH:D052684"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000484",
      "lbl" : "connective tissue type mast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Mast cell subtype whose granules contain both the serine proteases tryptase and chymase. These cells are primarily found in connective tissue, such as the peritoneal cavity, skin, and intestinal submucosa. Their development is T-cell independent.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19923473", "PMID:9354811" ]
        },
        "comments" : [ "They are CD88-positive. The cytoplasmic granules contain high levels of histamine and heparin (mouse) or major neutral proteases, tryptase, chymase, carboxypeptidase A, and cathepsin G (humans). Reportedly, they cannot produce leukotrienes (LTC4) and IL-4. They are reportedly very heterogeneous depending upon location and can convert to the MC(T) phenotype." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MC(TC)"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "MCTC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "TC mast cells"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000488",
      "lbl" : "visible light photoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A photoreceptor cell that detects visible light.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000492",
      "lbl" : "CD4-positive helper T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that cooperates with other lymphocytes via direct contact or cytokine release to initiate a variety of immune functions.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "MESH:D006377" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive T-helper cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive helper T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive helper T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive helper T-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1146"
        }, {
          "val" : "FMA:70572"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000498",
      "lbl" : "inhibitory interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An interneuron (also called relay neuron, association neuron or local circuit neuron) is a multipolar neuron which connects afferent neurons and efferent neurons in neural pathways. Like motor neurons, interneuron cell bodies are always located in the central nervous system (CNS).",
          "xrefs" : [ "GOC:tfm", "http://en.wikipedia.org/wiki/Interneuron" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:84776"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000499",
      "lbl" : "stromal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A connective tissue cell of an organ found in the loose connective tissue.",
          "xrefs" : [ "GOC:tfm", "MESH:D017154" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0002064"
        }, {
          "val" : "FMA:83624"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000501",
      "lbl" : "granulosa cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge. Granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle. The major functions of granulosa cells include the production of steroids and LH receptors.",
          "xrefs" : [ "MESH:D006107" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "granulosa cell of ovary"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000542"
        }, {
          "val" : "CALOHA:TS-0729"
        }, {
          "val" : "FMA:18718"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000502",
      "lbl" : "type D enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.",
          "xrefs" : [ "MESH:D019864" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "D cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62935"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000503",
      "lbl" : "theca cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized stromal cell that forms the theca layer outside the basal lamina lining the ovarian follicle, appearing during the secondary follicle stage.",
          "xrefs" : [ "MESH:D013799", "PMID:15833266", "PMID:36758341" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0002850"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000506",
      "lbl" : "enkephalin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endorphine cell that secretes enkephalin.",
          "xrefs" : [ "GO:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000507",
      "lbl" : "endorphin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell that secretes endorphin.",
          "xrefs" : [ "GO:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000508",
      "lbl" : "type G enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endocrine cell found in the stomach and duodenum and is responsible for the secretion of gastrin and enkephalin. Most abundant in pyloric antrum, pyramidal in form with a narrow apex bearing long microvilli.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "MESH:D019863", "PMID:10700044", "PMID:35674015", "PMID:37240181" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "G cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004108"
        }, {
          "val" : "FMA:67609"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000509",
      "lbl" : "gastrin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell that secretes gastrin.",
          "xrefs" : [ "GO:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000510",
      "lbl" : "paneth cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell found in the basal part of the intestinal glands (crypts of Lieberkuhn) including the appendix. Paneth cells synthesize and secrete lysozyme and cryptdins. Numerous in the deeper parts of the intestinal crypts, particularly in the duodenum, rich in zinc, contain large acidophilic granules, with irregular apical microvilli and prominent membrane-bound vacuoles containing matrix.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "MESH:D019879", "PMID:29184701", "PMID:32308658", "PMID:33484640" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0000993"
        }, {
          "val" : "FMA:62897"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000511",
      "lbl" : "androgen binding protein secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A peptide hormone secreting cell that secretes androgen binding protein.",
          "xrefs" : [ "GO:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000513",
      "lbl" : "cardiac muscle myoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor cell destined to differentiate into cardiac muscle cell.",
          "xrefs" : [ "GOC:tfm", "MESH:D032386" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cardiac muscle progenitor cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardiomyocyte progenitor cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84797"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000514",
      "lbl" : "smooth muscle myoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor cell destined to differentiate into smooth muscle myocytes.",
          "xrefs" : [ "GOC:tfm", "MESH:D032390" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "myoblast, smooth muscle",
          "xrefs" : [ "MESH:D032390" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "satellite cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84798"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000515",
      "lbl" : "skeletal muscle myoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoblast that differentiates into skeletal muscle fibers.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "skeletal myoblast"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84799"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000517",
      "lbl" : "macrophage derived foam cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of foam cell derived from a macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.",
          "xrefs" : [ "GOC:add", "PMID:20213546" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lipophage"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000518",
      "lbl" : "phagocyte (sensu Vertebrata)",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A phagocyte in vertebrates that is able to phagocytosis.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000521",
      "lbl" : "fungal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that in taxon some Fungi.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000525",
      "lbl" : "syncytiotrophoblast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell from the outer syncytial layer of the trophoblast of an early mammalian embryo, directly associated with the maternal blood supply. It secretes hCG in order to maintain progesterone secretion and sustain a pregnancy.",
          "xrefs" : [ "GOC:tfm", "ISBN:0323052908" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "syncytial trophoblast cell",
          "xrefs" : [ "PMID:11787150" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "syncytiotrophoblastic cell",
          "xrefs" : [ "PMID:21733368" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "plasmidotrophoblast cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "syntrophoblast cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83043"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000526",
      "lbl" : "afferent neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron which conveys sensory information centrally from the periphery.",
          "xrefs" : [ "GOC:tfm", "MESH:D009475" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "input neuron"
        } ],
        "xrefs" : [ {
          "val" : "FMA:87653"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000527",
      "lbl" : "efferent neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron which sends impulses peripherally to activate muscles or secretory cells.",
          "xrefs" : [ "MESH:D009476" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "output neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000540",
      "lbl" : "neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The basic cellular unit of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the nervous system.",
          "xrefs" : [ "MESH:D009474", "http://en.wikipedia.org/wiki/Neuron" ]
        },
        "comments" : [ "These cells are also reportedly CD4-negative and CD200-positive. They are also capable of producing CD40L and IFN-gamma." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nerve cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000938"
        }, {
          "val" : "CALOHA:TS-0683"
        }, {
          "val" : "FMA:54527"
        }, {
          "val" : "VHOG:0001483"
        }, {
          "val" : "WBbt:0003679"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000541",
      "lbl" : "melanoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that originates from the neural crest and differentiates into a pigment cell.",
          "xrefs" : [ "GOC:tfm", "SANBI:mhl" ]
        },
        "comments" : [ "Derived from UBERON:0002342 neural crest." ],
        "xrefs" : [ {
          "val" : "BTO:0003217"
        }, {
          "val" : "FMA:83377"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000542",
      "lbl" : "lymphocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin.",
          "xrefs" : [ "GOC:add", "ISBN:0683073696", "ISBN:0781735149" ]
        },
        "comments" : [ "Editors note: consider adding taxon constraint to vertebrata (PMID:18025161)" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000775"
        }, {
          "val" : "CALOHA:TS-0583"
        }, {
          "val" : "FMA:62863"
        }, {
          "val" : "MESH:D008214"
        }, {
          "val" : "VHOG:0001535"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000545",
      "lbl" : "T-helper 1 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive, CXCR3-positive, CCR6-negative, and is capable of producing interferon-gamma.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19375293", "PMID:20303875", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'Th1 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 1 T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T helper cells type 1",
          "xrefs" : [ "PMID:9419219" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T(H)-1 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th1 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T cell type 1"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001678"
        }, {
          "val" : "FMA:84382"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000546",
      "lbl" : "T-helper 2 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive, CXCR3-negative, CCR6-negative, and is capable of producing interleukin-4.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19375293", "PMID:20103781", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell' (see CL:0001051), but includes the additional necessary and sufficient conditions to allow classification as a T-helper 2 T cell." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T helper cells type 2",
          "xrefs" : [ "PMID:9419219" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T(H)-2 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th2 T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th2 T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th2 T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th2 T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th2 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T cell type 2"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001679"
        }, {
          "val" : "FMA:84385"
        }, {
          "val" : "MESH:D018418"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000547",
      "lbl" : "proerythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature, nucleated erythrocyte occupying the stage of erythropoeisis that follows formation of erythroid progenitor cells. This cell is CD71-positive, has both a nucleus and a nucleolus, and lacks hematopoeitic lineage markers.",
          "xrefs" : [ "ISBN:0721601464", "PMID:1638021" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "rubriblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pronormoblast"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83518"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000549",
      "lbl" : "basophilic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A nucleated immature erythrocyte, having cytoplasm generally similar to that of the earlier proerythroblast but sometimes even more basophilic, and usually regular in outline. The nucleus is still relatively large, but the chromatin strands are thicker and more deeply staining, giving a coarser appearance; the nucleoli have disappeared. This cell is CD71-positive and lacks hematopoeitic lineage markers.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basophilic normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "early erythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "early normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "prorubricyte",
          "xrefs" : [ "ISBN:0721601464" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:83505"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000550",
      "lbl" : "polychromatophilic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A nucleated, immature erythrocyte in which the nucleus occupies a relatively smaller part of the cell than in its precursor, the basophilic erythroblast. The cytoplasm is beginning to acquire hemoglobin and thus is no longer a purely basophilic, but takes on acidophilic aspects, which becomes progressively more marked as the cell matures. The chromatin of the nucleus is arranged in coarse, deeply staining clumps. This cell is CD71-positive and lacks hematopoeitic lineage markers.",
          "xrefs" : [ "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intermediate erythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intermediate normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polychromatic erythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polychromatic normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polychromatophilic normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "rubricyte",
          "xrefs" : [ "ISBN:0721601464" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:83506"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000552",
      "lbl" : "orthochromatic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The final stage of the nucleated, immature erythrocyte, before nuclear loss. Typically the cytoplasm is described as acidophilic, but it still shows a faint polychromatic tint. The nucleus is small and initially may still have coarse, clumped chromatin, as in its precursor, the polychromatophilic erythroblast, but ultimately it becomes pyknotic, and appears as a deeply staining, blue-black, homogeneous structureless mass. The nucleus is often eccentric and sometimes lobulated.",
          "xrefs" : [ "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acidophilic erythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "eosinophilic erythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "late erythoblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "orthochromatic normoblast",
          "xrefs" : [ "ISBN:0721601464" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pyknotic eto enrythroblast",
          "xrefs" : [ "ISBN:0721601464" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:84646"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000553",
      "lbl" : "megakaryocyte progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative).",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721601464" ]
        },
        "comments" : [ "Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CFU-Meg",
          "xrefs" : [ "PMID:11722431", "PMID:12482498" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Meg-CFC",
          "xrefs" : [ "PMCID:PMC1794060" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "MkP",
          "xrefs" : [ "PMID:21116988" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "colony-forming unit-megakaryocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megacaryoblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megacaryocyte progenitor cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megakaryoblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megakaryocytic progenitor cell",
          "xrefs" : [ "PMID:12482498" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "promegacaryocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "promegakaryocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001164"
        }, {
          "val" : "CALOHA:TS-0610"
        }, {
          "val" : "FMA:84235"
        }, {
          "val" : "MESH:D055016"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000556",
      "lbl" : "megakaryocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A large hematopoietic cell (50 to 100 micron) with a lobated nucleus. Once mature, this cell undergoes multiple rounds of endomitosis and cytoplasmic restructuring to allow platelet formation and release.",
          "xrefs" : [ "ISBN:0721601464", "MESH:D008533", "PMID:31043076", "http://en.wikipedia.org/wiki/Megakaryocyte" ]
        },
        "comments" : [ "Megakaryocytes are reportedly CD181-positive and CD182-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "megacaryocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megalocaryocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "megalokaryocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000843"
        }, {
          "val" : "CALOHA:TS-0611"
        }, {
          "val" : "FMA:83555"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000557",
      "lbl" : "granulocyte monocyte progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1.",
          "xrefs" : [ "GOC:amm", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "MESH:D055014", "PMCID:PMC2213186", "PMCID:PMC548021", "PMID:16551251", "PMID:16647566", "http://en.wikipedia.org/wiki/CFU-GM", "http://www.copewithcytokines.de" ]
        },
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "CFU-C , Colony forming unit in culture",
          "xrefs" : [ "http://www.copewithcytokines.de" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "colony forming unit granulocyte macrophage",
          "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "granulocyte-macrophage progenitor",
          "xrefs" : [ "ISBN:0721601464", "PMCID:PMC2213186", "PMCID:PMC548021" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "granulocyte/monocyte precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "granulocyte/monocyte progenitor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000558",
      "lbl" : "reticulocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature erythrocyte that changes the protein composition of its plasma membrane by exosome formation and extrusion. The types of protein removed differ between species though removal of the transferrin receptor is apparent in mammals and birds.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:15946868", "PMID:2037622" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001173"
        }, {
          "val" : "CALOHA:TS-0864"
        }, {
          "val" : "MESH:D012156"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000559",
      "lbl" : "promonocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor in the monocytic series, being a cell intermediate in development between the monoblast and monocyte. This cell is CD11b-positive and has fine azurophil granules.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721601464" ]
        },
        "comments" : [ "Morphology: Mononuclear cell, diameter 14-18 _M, fine azurophilic granules; markers: CD11b (shared with many other myeloid cells); location: Adult: bone marrow; Fetal: Liver, Yolk Sac; role or process: hematopoiesis, monocyte development; lineage: hematopoietic, myeloid." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0004657"
        }, {
          "val" : "FMA:83551"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000561",
      "lbl" : "amacrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Interneuron of the vertebrate retina. They integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. They lack large axons.",
          "xrefs" : [ "GOC:tfm", "MESH:D025042", "WikipediaVersioned:Amacrine_cell&oldid=1023572246" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amacrine neuron"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004044"
        }, {
          "val" : "FMA:67766"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000562",
      "lbl" : "nucleate erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An erythrocyte having a nucleus.",
          "xrefs" : [ "GOC:add", "GOc:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "RBC"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "red blood cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000566",
      "lbl" : "angioblastic mesenchymal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesenchymal stem cell capable of developing into blood vessel endothelium.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
        },
        "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, CD309-positive, and TAL1-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "angioblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "chondroplast"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000567",
      "lbl" : "polymodal nocireceptor",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000568",
      "lbl" : "amine precursor uptake and decarboxylation cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that originates in the neural crest, that has certain cytochemical and ultrastructural characteristics and is found scattered throughout the body; types include melanocytes, the cells of the chromaffin system, and cells in the hypothalamus, hypophysis, thyroid, parathyroids, lungs, gastrointestinal tract, and pancreas. This cell type concentrates the amino acid precursors of certain amines and decarboxylate them, forming amines that function as regulators and neurotransmitters. This cell type produces substances such as epinephrine, norepinephrine, dopamine, serotonin, enkephalin, somatostatin, neurotensin, and substance P, the actions of which may affect contiguous cells, nearby groups of cells, or distant cells, thus functioning as local or systemic hormones. The name is an acronym for amine precursor uptake and decarboxylation cell.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "APUD cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003866"
        }, {
          "val" : "FMA:83114"
        }, {
          "val" : "MESH:D001078"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000569",
      "lbl" : "cardiac mesenchymal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesenchymal cell found in the developing heart and that develops into some part of the heart.  These cells derive from intra- and extra-cardiac sources, including the endocardium, epicardium, neural crest, and second heart field.",
          "xrefs" : [ "PMID:18816864" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000570",
      "lbl" : "parafollicular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroepithelial cells that occurs singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid. This cell expresses a form of the neural cell adhesion molecule (N-CAM) on its surface and secretes calcitonin and serotonin (5-hydroxytryptamine).",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "C cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "C cell of thyroid gland",
          "xrefs" : [ "FMA:68653" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "clear cell of thyroid gland",
          "xrefs" : [ "FMA:68653" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "parafollicular cell of thyroid gland",
          "xrefs" : [ "FMA:68653" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "thyroid parafollicular cell",
          "xrefs" : [ "FMA:68653" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:68653"
        }, {
          "val" : "SCTID:176770005"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000573",
      "lbl" : "retinal cone cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.",
          "xrefs" : [ "MESH:D017949" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cone",
          "xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001036"
        }, {
          "val" : "CALOHA:TS-0866"
        }, {
          "val" : "FMA:67748"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000575",
      "lbl" : "corneal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the cornea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of cornea",
          "xrefs" : [ "FMA:70551" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004298"
        }, {
          "val" : "CALOHA:TS-0173"
        }, {
          "val" : "FMA:70551"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000576",
      "lbl" : "monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.",
          "xrefs" : [ "GO_REF:0000031", "MESH:D009000" ]
        },
        "comments" : [ "Morphology: Mononuclear cell, diameter, 14 to 20 _M, N/C ratio 2:1-1:1. Nucleus may appear in variety of shapes: round, kidney, lobulated, or convoluted. Fine azurophilic granules present; markers: CD11b (shared with other myeloid cells), human: CD14, mouse: F4/80-mid,GR1-low; location: Blood, but can be recruited into tissues; role or process: immune & tissue remodelling; lineage: hematopoietic, myeloid." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000876"
        }, {
          "val" : "CALOHA:TS-0638"
        }, {
          "val" : "FMA:62864"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000581",
      "lbl" : "peritoneal macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A macrophage resident in the peritoneum under non-inflammatory conditions. Markers include F4/80-high, CD11b-high, CD68-positive, SIGNR1-positive, CD115-high, MHC-II-negative, and Dectin-1-positive.",
          "xrefs" : [ "MESH:D017737", "PMID:15771589", "PMID:19201820" ]
        },
        "comments" : [ "Markers: Mouse: F4/80-high, CD11b-high, CD68+, SIGNR1+, Dectin-1+." ],
        "xrefs" : [ {
          "val" : "BTO:0001034"
        }, {
          "val" : "FMA:83025"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000583",
      "lbl" : "alveolar macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage found in the alveoli of the lungs. Ingests small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells. Markers include F4/80-positive, CD11b-/low, CD11c-positive, CD68-positive, sialoadhesin-positive, dectin-1-positive, MR-positive, CX3CR1-negative.",
          "xrefs" : [ "GOC:ana", "GOC:dsd", "GOC:tfm", "GO_REF:0000031", "MESH:D016676" ]
        },
        "comments" : [ "Markers: Mouse: F4/80mid, CD11b-/low, CD11c+, CD68+, sialoadhesin+, dectin-1+, MR+, CX3CR1-.", "The marker set MSR1, FABP4 can identify the Human cell type alveolar macrophage in the lung with a confidence of 0.80 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "dust cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "MF.Lu"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000802"
        }, {
          "val" : "CALOHA:TS-0030"
        }, {
          "val" : "FMA:83023"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000584",
      "lbl" : "enterocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that has its apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "differentiated enterocyte",
          "xrefs" : [ "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mature enterocyte",
          "xrefs" : [ "PMID:33290721", "https://orcid.org/0000-0001-9610-7627" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000398"
        }, {
          "val" : "FMA:62122"
        }, {
          "val" : "MESH:D020895"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000586",
      "lbl" : "germ cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The reproductive cell in multicellular organisms.",
          "xrefs" : [ "MESH:D005854" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0000535"
        }, {
          "val" : "NCIT:C12597"
        }, {
          "val" : "VHOG:0001534"
        }, {
          "val" : "WBbt:0006796"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000588",
      "lbl" : "odontoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized osteoclast associated with the absorption and removal of cementum.",
          "xrefs" : [ "GOC:add" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0002516"
        }, {
          "val" : "FMA:83027"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000589",
      "lbl" : "cochlear inner hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bulbous cell that is medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated.",
          "xrefs" : [ "MESH:D006199" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "inner hair cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003667"
        }, {
          "val" : "FMA:62365"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000593",
      "lbl" : "androgen secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A steroid hormone secreting cell that secretes androgen.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000594",
      "lbl" : "skeletal muscle satellite cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An elongated, spindle-shaped, cell that is located between the basal lamina and the plasmalemma of a muscle fiber. These cells are mostly quiescent, but upon activation they divide to produce cells that generate new muscle fibers.",
          "xrefs" : [ "GOC:tfm", "MESH:D032496", "PMID:21849021", "PMID:23303905" ]
        },
        "comments" : [ "Skeletal muscle satellite cells are not traditionally referred to as myoblasts.  They are a heterogeneous population whose division, following activiation, contributes to the formation of skeletal muscle fibers and to maintenance of the skeletal muscle statelite cell population." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000595",
      "lbl" : "enucleate erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An erythrocyte lacking a nucleus.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "red blood cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000598",
      "lbl" : "pyramidal neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Pyramidal neurons have a pyramid-shaped soma with a single axon, a large apical dendrite and multiple basal dendrites. The apex and an apical dendrite typically point toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their region. Pyramidal neurons are found in the cerebral cortex, the hippocampus, and the amygdala.",
          "xrefs" : [ "GOC:tfm", "MESH:D017966" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "projection neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pyramidal cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003102"
        }, {
          "val" : "FMA:67310"
        }, {
          "val" : "FMA:86775"
        }, {
          "val" : "NIFSTD:sao862606388"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000601",
      "lbl" : "cochlear outer hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mechanoreceptor in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea.",
          "xrefs" : [ "MESH:D018072" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0003666"
        }, {
          "val" : "FMA:62366"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000602",
      "lbl" : "pressoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A receptor in the vascular system, particularly the aorta and carotid sinus, which is sensitive to stretch of the vessel walls.",
          "xrefs" : [ "MESH:D011311" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000604",
      "lbl" : "retinal rod cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.",
          "xrefs" : [ "MESH:D017948" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "rod",
          "xrefs" : [ "doi:10.1038/s41598-020-66092-9" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001024"
        }, {
          "val" : "CALOHA:TS-0870"
        }, {
          "val" : "FMA:67747"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000609",
      "lbl" : "vestibular hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mechanoreceptor located in the acoustic maculae and the semicircular canals that mediates the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem.",
          "xrefs" : [ "GOC:tfm", "MESH:D018069" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "vestibular receptor cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62351"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000617",
      "lbl" : "GABAergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that uses GABA as a vesicular neurotransmitter",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GABA-ergic neuron"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84788"
        }, {
          "val" : "MESH:D059330"
        }, {
          "val" : "WBbt:0005190"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000618",
      "lbl" : "sheath cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000622",
      "lbl" : "acinar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A secretory cell that is grouped together with other cells of the same type to form grape shaped clusters known as acini (singular acinus).",
          "xrefs" : [ "GOC:tfm", "http://www.copewithcytokines.de" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acinic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acinous cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83625"
        }, {
          "val" : "MESH:D061354"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000623",
      "lbl" : "natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:15771571" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "large granular lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "null cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "NK cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000914"
        }, {
          "val" : "BTO:0004716"
        }, {
          "val" : "CALOHA:TS-0664"
        }, {
          "val" : "FMA:63147"
        }, {
          "val" : "FMA:83601"
        }, {
          "val" : "MESH:D007694"
        }, {
          "val" : "VHOG:0001697"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000624",
      "lbl" : "CD4-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature alpha-beta T cell that expresses an alpha-beta T cell receptor and the CD4 coreceptor.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000625",
      "lbl" : "CD8-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell expressing an alpha-beta T cell receptor and the CD8 coreceptor.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000626",
      "lbl" : "olfactory granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors.",
          "xrefs" : [ "GOC:mah", "doi:10.1038/s41598-018-27692-8" ]
        },
        "comments" : [ "Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "olfactory bulb granule cell",
          "xrefs" : [ "doi:10.1038/s41598-018-27692-8" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000630",
      "lbl" : "supporting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell whose primary function is to support other cell types.",
          "xrefs" : [ "FB:ma", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "supportive cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002315"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000632",
      "lbl" : "hepatic stellate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver.",
          "xrefs" : [ "GOC:dsd", "MESH:D055166", "PMID:12808230", "PMID:17239632", "PMID:18222966", "PMID:9302568", "http://en.wikipedia.org/wiki/Hepatic_stellate_cell" ]
        },
        "comments" : [ "Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Ito cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hepatic perisinusoidal cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perisinusoidal cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "fat-storing cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lipocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "vitamin A-storing cells",
          "xrefs" : [ "PMID:12808230" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002741"
        }, {
          "val" : "CALOHA:TS-0452"
        }, {
          "val" : "FMA:67763"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000633",
      "lbl" : "Hensen cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tall supporting cell that is arranged in rows adjacent to the last row of outer phalangeal cells. This cell type constitutes the outer border of the organ of Corti.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Hensen's cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell of Hensen"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "external limiting cell of organ of Corti"
        } ],
        "xrefs" : [ {
          "val" : "FMA:79799"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000634",
      "lbl" : "Claudius cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cuboidal cell which along with Boettcher's cells form the floor of the external spiral sulcus, external to the organ of Corti.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell of Claudius"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "external supporting cell of Claudius"
        } ],
        "xrefs" : [ {
          "val" : "FMA:79802"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000635",
      "lbl" : "Deiter's cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The outer phalangeal cells of the organ of Corti. This cell holds the base of the hair cell in a cup-shaped depression.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "http://www.britannica.com/EBchecked/topic/156177/Deiters-cell" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Deiters cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "outer phalangeal cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:75725"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000636",
      "lbl" : "Mueller cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Astrocyte-like radial glial cell that extends vertically throughout the retina, with the nucleus are usually in the middle of the inner nuclear layer.",
          "xrefs" : [ "GOC:NV", "PMID:21911394" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Muller glia"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Müller cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003064"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000637",
      "lbl" : "chromophil cell of anterior pituitary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that stains readily in the anterior pituitary gland.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83089"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000638",
      "lbl" : "acidophil cell of pars distalis of adenohypophysis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An acidophilic chromophil cell that of the anterior pituitary gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acidophil cell of pars anterior of adenohypophysis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acidophil of pars anterior of adenohypophysis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acidophil of pars distalis of adenohypophysis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pituitary alpha cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83093"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000639",
      "lbl" : "basophil cell of pars distalis of adenohypophysis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basophilic chromophil cell that of the anterior pituitary gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basophil cell of anterior lobe of hypophysis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "beta cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pituitary beta cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83094"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000642",
      "lbl" : "folliculostellate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An agranular supporting cell of the anterior pituitary (adenohypophysis) that is characterized by a star-like morphology and ability to form follicles. Folliculostellate cells communicate with each other and with endocrine cells via gap junctions.",
          "xrefs" : [ "JB:jb", "PMID:10495875", "PMID:15961560", "doi:10.23937/2572-407X.1510006" ]
        },
        "comments" : [ "Folliculostellate cells are a heterogeneous group of cells rather than a single cell type, with different morphology and gene expression profiles. Due to this heterogeneity, it is unclear if different properties that have been attributed to folliculostellate cells (pluripotent, proliferative, phagocytic) are common in all folliculostellate cells or limited to particular subsets." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "folliculo-stellate cell",
          "xrefs" : [ "doi:10.23937/2572-407X.1510006" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pituitary folliculostellate cell",
          "xrefs" : [ "PMID:34734454" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Sox2-positive stem cell",
          "xrefs" : [ "PMID:34734454" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000644",
      "lbl" : "Bergmann glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Type of radial astrocyte in the cerebellar cortex that have their cell bodies in the Purkinje cell layer and processes that extend into the molecular layer, terminating with bulbous endfeet at the pial surface. Bergmann glia express high densities of glutamate transporters that limit diffusion of the neurotransmitter glutamate during its release from synaptic terminals. Besides their role in early development of the cerebellum, Bergmann glia are also required for the pruning or addition of synapses.",
          "xrefs" : [ "GOC:tfm", "http://www.neurolex.org/wiki/Category:Bergmann_Glial_Cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bergmann astrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bergmann glial cell of cerebellum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:54559"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000645",
      "lbl" : "pituicyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glial cell of astrocytic lineage with long processes running parallel to adjacent axons in the proximal infundibulum of the neurohypophysis. These processes form a three-dimensional network among the axons of the hypothalamic neurosecretory cells and are connected by gap junctions which provide for their metabolic coupling. This cell type constitutes most of the nonexcitable tissue in the neurohypophsis; function may include possibly acting as an intermediate in the modulation of oxytocin and vasopressin release. This cell type is highly variable in size and shape and commonly contain lipid droplets and deposits of lipochrome pigment.",
          "xrefs" : [ "ISBN:0412046911", "ISBN:0517223651", "PMID:31915267", "http://en.wikipedia.org/wiki/Pituicyte" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0003793"
        }, {
          "val" : "FMA:83503"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000646",
      "lbl" : "basal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Undifferentiated; mitotic stem cell for other epithelial cell types; rounded or elliptical with little cytoplasm and few organelles; contain cytokeratin intermediate filament.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0000939"
        }, {
          "val" : "FMA:62516"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000648",
      "lbl" : "kidney granular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that synthesizes, stores, and secretes the enzyme renin. This cell type are located in the wall of the afferent arteriole at the entrance to the glomerulus. While having a different origin than other kidney smooth muscle cells, this cell type expresses smooth muscle actin upon maturation.",
          "xrefs" : [ "GOC:cvs", "GOC:tfm", "PMID:11457727" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "juxtaglomerular cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "JG cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "renin secreting cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84138"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000649",
      "lbl" : "spinous cell of epidermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A keratinocyte found within the stratum spinosum (prickle cell layer) of the epidermis, distinguished by numerous intercellular desmosomes, which give it a “prickly” or spiny appearance. Positioned above the mitotically active basal layer and beneath the granular layer, it contributes to the skin’s mechanical strength and barrier function, preventing water loss and pathogen entry. This cell expresses differentiation-specific keratins K1 and K10 in mice, unlike basal cells that express K5 and K14, and lacks the keratohyalin granules found in granular cells, marking its intermediate stage of epidermal differentiation.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "ISBN:0815332181", "PMID:21860392", "PMID:32097634", "WIKIPEDIA:Spinous_cell" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "prickle cell of epidermis",
          "xrefs" : [ "WIKIPEDIA:Spinous_cell" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "spinous keratinocytes of epidermis",
          "xrefs" : [ "PMID:32843640" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:69059"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000650",
      "lbl" : "mesangial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell type that encapsulates the capillaries and venules in the kidney. This cell secretes mesangial matrix that provides the structural support for the capillaries.",
          "xrefs" : [ "GOC:tfm", "http://www.copewithcytokines.de/cope.cgi?key=mesangial%20cells" ]
        },
        "comments" : [ "Do all of these cells really develop from some mesenchymal stem cell?" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "kidney mesangial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000853"
        }, {
          "val" : "CALOHA:TS-0617"
        }, {
          "val" : "FMA:70972"
        }, {
          "val" : "MESH:D050527"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000652",
      "lbl" : "pinealocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "This cell type produces and secretes melatonin and forms the pineal parenchyma. Extending from each cell body, which has a spherical, oval or lobulated mucleus, are one or more tortuous basophilic processes, containing parallel microtubules known as synaptic ribbons. These processes end in expanded terminal buds near capillaries or less, frequently, ependymal cells of the pineal recess. The terminal buds contain granular endoplasmic reticulum, mitochondria and electron-dense cored vesicles, which store monoamines and polypeptide hormones, release of which appears to require sympathetic innervation.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:16687276", "http://en.wikipedia.org/wiki/Pinealocyte" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001068"
        }, {
          "val" : "FMA:83417"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000653",
      "lbl" : "podocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized kidney epithelial cell, contained within a glomerulus, that contains \"feet\" that interdigitate with the \"feet\" of other podocytes.",
          "xrefs" : [ "GOC:tfm", "https://doi.org/10.1101/2021.10.10.463829" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "epithelial cell of visceral layer of glomerular capsule",
          "xrefs" : [ "FMA:70967" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glomerular podocyte",
          "xrefs" : [ "FMA:70967" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glomerular visceral epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "kidney podocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "renal podocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002295"
        }, {
          "val" : "FMA:70967"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000654",
      "lbl" : "primary oocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A primary oocyte is an oocyte that has not completed female meosis I.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "primary oogonium"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000512"
        }, {
          "val" : "FMA:18645"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000655",
      "lbl" : "secondary oocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A secondary oocyte is an oocyte that has not completed meiosis II.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "primary oogonium"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003094"
        }, {
          "val" : "FMA:18646"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000656",
      "lbl" : "primary spermatocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A diploid cell that has derived from a spermatogonium and can subsequently begin meiosis and divide into two haploid secondary spermatocytes.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0001115"
        }, {
          "val" : "CALOHA:TS-2194"
        }, {
          "val" : "FMA:72292"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000657",
      "lbl" : "secondary spermatocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "One of the two haploid cells into which a primary spermatocyte divides, and which in turn gives origin to spermatids.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0000709"
        }, {
          "val" : "CALOHA:TS-2195"
        }, {
          "val" : "FMA:72293"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000666",
      "lbl" : "fenestrated endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that has small pores, or fenestrations, which allow for the efficient exchange of substances between the blood and surrounding tissues.",
          "xrefs" : [ "DOI:10.1007/978-3-211-99390-3_133" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "window cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000667",
      "lbl" : "collagen secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An extracellular matrix secreting cell that secretes collagen.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000669",
      "lbl" : "pericyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An elongated, contractile cell found wrapped about precapillary arterioles outside the basement membrane. Pericytes are present in capillaries where proper adventitia and muscle layer are missing (thus distingushing this cell type from adventitial cells). They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "ISBN:0721662544", "MESH:D020286", "PMID:16807374", "PMID:17986482", "PMID:20024907" ]
        },
        "comments" : [ "Pericytes are CD10-positive, CD13-positive, CD31-negative, CD45-negative, CD106-positive, CD117-negative, CD140-positive, CD144-negative, CD146-positive, CD271-positive, CD325-positive, NG2-positive, RGS5-positive, SMA-positive, and desmin-positive. A subpopulation is CD248-positive. They are also capable of producing angiopoietin 1, CXCL12, TGF-beta, and VEGF-A." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ARC",
          "xrefs" : [ "PMID:17986482" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adventitial reticular cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell of Rouget"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pericyte cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pericyte of Rouget"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "adventitial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002441"
        }, {
          "val" : "FMA:63174"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000670",
      "lbl" : "primordial germ cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A primordial germ cell is a diploid germ cell precursors that transiently exist in the embryo before they enter into close association with the somatic cells of the gonad and become irreversibly committed as germ cells.",
          "xrefs" : [ "GOC:tfm", "PMID:1381289" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gonocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "primitive germ cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70567"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000675",
      "lbl" : "female gamete",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature sexual reproductive cell of the female germline.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000677",
      "lbl" : "gut absorptive cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell of the intestinal epithelium with a brush border made up of many parallel packed microvilli; associated with absorption, particularly of macromolecules.",
          "xrefs" : [ "JB:jb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000679",
      "lbl" : "glutamatergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that is capable of some neurotansmission by glutamate secretion."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "WBbt:0006829"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000680",
      "lbl" : "muscle precursor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-terminally differentiated cell that is capable of developing into a muscle cell.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000681",
      "lbl" : "radial glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell present in the developing CNS. Functions as both a precursor cell and as a scaffold to support neuronal migration.",
          "xrefs" : [ "GOC:dph" ]
        },
        "comments" : [ "Unlike that of mammals, the brain of adult teleost fish exhibits an intense and widespread neurogenic activity as a result of the persistence of\nradial glial cells acting as neural progenitors throughout life." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "forebrain radial glial cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000686",
      "lbl" : "cerebrospinal fluid secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A columnar/cuboidal epithelial cell that secretes cerebrospinal fluid.",
          "xrefs" : [ "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000691",
      "lbl" : "stellate interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any interneuron that has characteristic some stellate morphology.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#BDS_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000695",
      "lbl" : "Cajal-Retzius cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of transient, early-born glutamatergic neuron located primarily in the marginal zone (future layer I) of the developing cerebral cortex and hippocampus in vertebrates. it is characterized by a bipolar morphology with an elongated soma, a single thick dendrite oriented toward the pial surface, and a long, thin axon that extends tangentially to form horizontal plexuses across the cortical surface. It is important for the multiple developmental processes including migration, dendritogenesis and synaptogenesis. It typically undergoes programmed cell death following cortical maturation with species- and region specific patterns of survival. In mice, it is predominantly observed in the hippocampal formation, particularly in the stratum lacunosum-moleculare and outer molecular layer of the dentate gyrus (van Bruggen et al., 2023). In contrast, in humans, a second morphologically distinct subpopulation emerges mid-gestation and persists postnatally, with surviving cells observed in the cortical sulci and the hippocampus.",
          "xrefs" : [ "PMID:10600995", "PMID:34047341", "PMID:36774666", "PMID:37775311", "PMID:9728912" ]
        },
        "comments" : [ "While previously called 'pioneer neurons' of the marginal zone, Cajal-Retzius cells are differentiated from pioneer neurons (which are Reln-negative) by their Reln-immunoreactivity." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CR cells",
          "xrefs" : [ "WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Horizontal cells of Cajal",
          "xrefs" : [ "WikipediaVersioned:Cajal–Retzius_cell&oldid=1032081753" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-7258-9596"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000696",
      "lbl" : "PP cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that stores and secretes pancreatic polypeptide hormone.",
          "xrefs" : [ "GOC:tfm", "JB:jb", "PMID:15153415" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "type F enteroendocrine cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62938"
        }, {
          "val" : "FMA:83409"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000700",
      "lbl" : "dopaminergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that releases dopamine as a neurotransmitter.",
          "xrefs" : [ "GOC:dhill" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "dopaminergic cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004032"
        }, {
          "val" : "FMA:84787"
        }, {
          "val" : "MESH:D059290"
        }, {
          "val" : "WBbt:0006746"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000703",
      "lbl" : "sustentacular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell that provides some or all mechanical, nutritional and phagocytic support to their neighbors.",
          "xrefs" : [ "JB:jb" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0002315"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000706",
      "lbl" : "choroid plexus epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized ependymal cell that is part of the choroid plexus epithelium, responsible for producing cerebrospinal fluid (CSF) by selectively filtering and modifying blood plasma components before secreting it into the brain and spinal cord. This cell is characterized by a brush border on its apical surface, which enhances the secretion of CSF.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "JB:jb", "PMID:15561411", "PMID:9550134" ]
        },
        "comments" : [ "A choroid plexus epithelial cell possesses non-motile 9+0 cilia. While these cilia can exhibit transient motility during development, they generally do not contribute significantly to the directional flow of cerebrospinal fluid (CSF). Instead, they are primarily involved in sensory functions." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "choroid plexus cell",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of choroid plexus"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70549"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-08-04T08:48:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000708",
      "lbl" : "leptomeningeal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Stromal cell that forms the internal covering of the vertebrate brain and produces ECM for this and the choroid plexus.",
          "xrefs" : [ "JB:jb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "leptomemingeal cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000710",
      "lbl" : "neurecto-epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Epithelial cells derived from neural plate and neural crest.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "The term \"neuroepithelial cell\" is used to describe both this cell type and sensory epithelial cell (CL:0000098)." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "neuroepithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004301"
        }, {
          "val" : "FMA:70557"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000712",
      "lbl" : "stratum granulosum cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epidermal cell that is part of some stratum granulosum of epidermis.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000723",
      "lbl" : "somatic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that can give rise to cell types of the body other than those of the germ-line.",
          "xrefs" : [ "GO:0048103" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2086"
        }, {
          "val" : "MESH:D053687"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000731",
      "lbl" : "urothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of a layer of transitional epithelium in the wall of the proximal urethra, bladder, ureter or renal pelvis, external to the lamina propria.",
          "xrefs" : [ "GOC:tfm", "MA:ma", "doi:10.1038/s41385-022-00565-0" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "urinary tract transitional epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84127"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000737",
      "lbl" : "striated muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Muscle cell which has as its direct parts myofilaments organized into sarcomeres.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0002916"
        }, {
          "val" : "CALOHA:TS-2157"
        }, {
          "val" : "FMA:86936"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000738",
      "lbl" : "leukocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:978-0-323-05290-0" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "white blood cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "immune cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000751"
        }, {
          "val" : "CALOHA:TS-0549"
        }, {
          "val" : "FMA:62852"
        }, {
          "val" : "MESH:D007962"
        }, {
          "val" : "NCIT:C12529"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000740",
      "lbl" : "retinal ganglion cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The set of neurons that receives neural inputs via bipolar, horizontal and amacrine cells. The axons of these cells make up the optic nerve.",
          "xrefs" : [ "GOC:dph" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gangliocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ganglion cell of retina"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001800"
        }, {
          "val" : "FMA:67765"
        }, {
          "val" : "MESH:D012165"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000745",
      "lbl" : "retina horizontal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that laterally connects other neurons in the inner nuclear layer of the retina.",
          "xrefs" : [ "ISBN:0195088433" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "horizontal cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004120"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000746",
      "lbl" : "cardiac muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.",
          "xrefs" : [ "GOC:mtg_cardiacconduct_nov11", "GOC:tfm", "ISBN:0323052908", "PMID:22426062", "PMID:4711263" ]
        },
        "comments" : [ "This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods.  The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein).  According to these refs, the cells participating in heart contraction in all cases are transversely striated.  Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cardiocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardiac muscle fiber",
          "xrefs" : [ "GO:0048739" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardiac myocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardiomyocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "heart muscle cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001539"
        }, {
          "val" : "CALOHA:TS-0115"
        }, {
          "val" : "FMA:14067"
        }, {
          "val" : "MESH:D032383"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000748",
      "lbl" : "retinal bipolar neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner plexiform layer.",
          "xrefs" : [ "PMID:14689473" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000749",
      "lbl" : "ON-bipolar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bipolar neuron found in the retina and having connections with photoreceptors cells and neurons in the inner half of the inner plexiform layer. These cells depolarize in response to light stimulation of their corresponding photoreceptors.",
          "xrefs" : [ "PMID:14689473" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000751",
      "lbl" : "rod bipolar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bipolar neuron found in the retina that is synapsed by rod photoreceptor cells but not by cone photoreceptor cells.  These neurons depolarize in response to light.",
          "xrefs" : [ "GOC:tfm", "PMID:14689473" ]
        },
        "comments" : [ "The marker set CDHR3, PRKCA-AS1 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000751 in the retina with a confidence of 0.929575519 (NS-Forest FBeta value).", "The marker set ENSG00000227681, C16orf74 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000751 in the retina with a confidence of 0.907779697 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:67750"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000752",
      "lbl" : "cone retinal bipolar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bipolar neuron found in the retina and having connections with cone photoreceptor cells and neurons in the inner plexiform layer.",
          "xrefs" : [ "PMID:14689473" ]
        },
        "comments" : [ "The marker set COL19A1, DOK5 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000752 in the retina with a confidence of 0.843060252 (NS-Forest FBeta value).", "The marker set DOK5, ST6GALNAC3 can identify the Human cell type http://purl.obolibrary.org/obo/CL_0000752 in the retina with a confidence of 0.782434709 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000762",
      "lbl" : "nucleated thrombocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A nucleated blood cell involved in coagulation, typically seen in birds and other non-mammalian vertebrates.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:16360205" ]
        },
        "comments" : [ "Note that this is a non-mammalian cell type. Use platelet ; CL:0000233 for thrombocytes (platelets) in mammals." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000763",
      "lbl" : "myeloid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001441"
        }, {
          "val" : "CALOHA:TS-0647"
        }, {
          "val" : "MESH:D022423"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000764",
      "lbl" : "erythroid lineage cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A immature or mature cell in the lineage leading to and including erythrocytes.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        },
        "comments" : [ "Note that in FMA erythropoietic cells are types of nucleated erythrocytes and thus don't include erythrocytes." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "erythropoietic cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0290"
        }, {
          "val" : "FMA:62845"
        }, {
          "val" : "FMA:83516"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000765",
      "lbl" : "erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A nucleated precursor of an erythrocyte that lacks hematopoietic lineage markers.",
          "xrefs" : [ "GOC:add", "ISBN:0721601464", "PMID:18174176" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "normoblast"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001571"
        }, {
          "val" : "CALOHA:TS-0289"
        }, {
          "val" : "FMA:83504"
        }, {
          "val" : "MESH:D004900"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000766",
      "lbl" : "myeloid leukocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the monocyte, granulocyte, or mast cell lineage.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000767",
      "lbl" : "basophil",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size. Basophils contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation. A basophil is CD123-positive, CD193-positive, CD203c-positive, and FceRIa-positive.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "MESH:D001491", "PMCID:PMC2626675", "PMID:11927641", "PMID:19741522", "PMID:21236338", "PMID:9933081" ]
        },
        "comments" : [ "Matures in the bone marrow and account for <1% of leukocytes in the peripheral blood, spleen, and bone marrow. Basophils are described as being CD11a-positive, CD11b-positive, CD13-positive, CD15-positive, CD18-positive, CD21-positive, CD25-positive, CD29-positive, CD35-positive, CD40-positive, CD40L-positive, CD44-positive, CD45R-negative, CD46-positive, CD49a-positive, CD49b-positive, CD49d-positive, CD55-positive, CD59-positive, CD62L-positive, CD63-positive, CD69-positive, CD90-negative, CD116-positive, CD117-negative, CD124-positive, CD125-positive, CD131-positive, CD161-positive, CD184-positive, CD191-positive, CD192-positive, CD197-positive, CD200R3-positive, CD218-positive, CD282-positive, CD284-positive, CD289-positive, CD290-positive, CD294-positive, natural killer cell receptor 2B4-positive, smad1-positive, CD3-negative, CD4-negative, CD7-negative, CD8-negative, CD14-negative, CD15-negative, CD16-negative, CD19-negative, CD20-negative, CD34-negative, CD36-negative, CD45R-negative, CD56-negative, CD57-negative, CD235a-negative, and GR1-negative. Transcription factors- GATA1-positive, PU.1-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leucocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leukocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "basophilic leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "basophilic leukocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000129"
        }, {
          "val" : "CALOHA:TS-0073"
        }, {
          "val" : "FMA:62862"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000771",
      "lbl" : "eosinophil",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin. Eosinophils are CD9-positive, CD191-positive, and CD193-positive.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:dsd", "GOC:tfm", "ISBN:0721601464", "PMCID:PMC2626675", "PMID:10914487", "PMID:1662676" ]
        },
        "comments" : [ "Eosinophils are also CD14-negative, CD32-positive, CD44-positive, CD48-positive, CD69-positive, CD192-negative, MBP1-positive, MBP2-positive, TLR2-negative, TLR4-negative, and lineage-negative (B220, CD2, CD14, CD19, CD56, CD71, CD117, CD123, CD235a (glycophorin A), and TER119). The cytokines IL-3, IL-5, and GM-CSF are involved in their development and differentiation. Usually considered CD16-negative, CD16 is observed on eosinophilic metamyelocyte." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leucocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leukocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "eosinocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "eosinophilic granulocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "eosinophilic leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "eosinophilic leukocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000399"
        }, {
          "val" : "CALOHA:TS-0279"
        }, {
          "val" : "FMA:62861"
        }, {
          "val" : "MESH:D004804"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000775",
      "lbl" : "neutrophil",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "PMN"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "poly"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leucocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear leukocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polymorphonuclear neutrophil"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polynuclear neutrophilic leucocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "polynuclear neutrophilic leukocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neutrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neutrophil leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neutrophil leukocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neutrophilic leucocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neutrophilic leukocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000130"
        }, {
          "val" : "CALOHA:TS-0688"
        }, {
          "val" : "FMA:62860"
        }, {
          "val" : "MESH:D009504"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000777",
      "lbl" : "mesangial phagocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage of the renal glomerular mesangium involved in the disposal and degradation of filtration residues, presentation of antigen to T cells and in tissue remodeling.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0702022918", "ISBN:3540536663", "PMID:1600140", "PMID:16146841" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "mesangial cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000778",
      "lbl" : "mononuclear osteoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized mononuclear osteoclast associated with the absorption and removal of bone, precursor of multinuclear osteoclasts.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:12713016", "PMID:15055519", "PMID:17380158", "PMID:9415452" ]
        },
        "comments" : [ "Morphology: mononuclear, highly vesicular." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000779",
      "lbl" : "multinuclear osteoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized multinuclear osteoclast, forming a syncytium through the fusion of mononuclear precursor cells, associated with the absorption and removal of bone.",
          "xrefs" : [ "GOC:add", "PMID:12713016", "PMID:29379067", "PMID:38903088", "PMID:9415452" ]
        },
        "comments" : [ "Morphology: multinucleated, highly vesicular." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "multinucleated osteoclast"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000780",
      "lbl" : "multinuclear odontoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized multinuclear osteoclast associated with the absorption and removal of cementum.",
          "xrefs" : [ "GOC:add", "PMID:9415452" ]
        },
        "comments" : [ "Morphology: multinucleated, highly vesicular; location: roots of deciduous (milk) teeth." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "multinucleated odontoclast"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000781",
      "lbl" : "mononuclear odontoclast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized mononuclear osteoclast associated with the absorption and removal of cementum.",
          "xrefs" : [ "GOC:add", "PMID:9415452" ]
        },
        "comments" : [ "Morphology: Mononuclear, highly vesicular; location: roots of deciduous (milk) teeth." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000782",
      "lbl" : "myeloid dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dendritic cell of the myeloid lineage.",
          "xrefs" : [ "GOC:add", "PMID:10449155", "PMID:17332250", "PMID:9521319" ]
        },
        "comments" : [ "These cells are CD1a-negative, CD1b-positive, CD11a-positive, CD11c-positive, CD13-positive, CD14-negative, CD20-negative, CD21-negative, CD33-positive, CD40-negative, CD50-positive, CD54-positive, CD58-positive, CD68-negative, CD80-negative, CD83-negative, CD85j-positive, CD86-positive, CD89-negative, CD95-positive, CD120a-negative, CD120b-positive, CD123-negative, CD178-negative, CD206-negative, CD207-negative, CD209-negative, and TNF-alpha-negative. Upon TLR stimulation, they are capable of producing high levels of TNF-alpha, IL-6, CXCL8 (IL-8)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "interdigitating cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "veiled cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD11c+CD123- DC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mDC"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004721"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000783",
      "lbl" : "multinucleated phagocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A phagocyte formed by the fusion of mononuclear phagocytes.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000784",
      "lbl" : "plasmacytoid dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dendritic cell type of distinct morphology, localization, and surface marker expression (CD123-positive) from other dendritic cell types and associated with early stage immune responses, particularly the release of physiologically abundant amounts of type I interferons in response to infection.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "PMCID:PMC2118448", "PMCID:PMC538703", "PMID:15549123", "PMID:17332250", "PMID:17850486", "PMID:20304825" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DC2"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IPC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-associated plasma cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "interferon-producing cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lymphoid dendritic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pDC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasmacytoid T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasmacytoid monocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 DC"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004625"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000785",
      "lbl" : "mature B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B cell that is mature, having left the bone marrow. Initially, these cells are IgM-positive and IgD-positive, and they can be activated by antigen.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "ISBN:0781735149" ]
        },
        "comments" : [ "Mature B cells are also reportedly CD10-negative, CD19-positive, CD22-positive, CD34-negative, CD48-positive, CD79a-positive, CD84-positive, CD127-negative, CD352-positive, RAG-negative, TdT-negative, Vpre-B-negative, and pre-BCR-negative. Transcription factors expressed: Pax5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000786",
      "lbl" : "plasma cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A terminally differentiated, post-mitotic, antibody secreting cell of the B cell lineage with the phenotype CD138-positive, surface immunonoglobulin-negative, and MHC Class II-negative. Plasma cells are oval or round with extensive rough endoplasmic reticulum, a well-developed Golgi apparatus, and a round nucleus having a characteristic cartwheel heterochromatin pattern and are devoted to producing large amounts of immunoglobulin.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149", "PMID:19447676", "PMID:20081059", "PMID:20839338", "PMID:20951740", "http://en.wikipedia.org/wiki/Plasma_cell" ]
        },
        "comments" : [ "Plasma cells develop in the spleen and migrate to the bone marrow. Plasma cells are also reportedly CD5-negative, CD10-negative, CD19-positive, CD20-negative, CD21-negative, CD22-negative, CD23-negative, CD24-negative, CD25-negative, CD27-positive, CD34-negative, CD38-positive, CD40-positive, CD43-positive, CD45-positive, CD48-positive, CD53-low, CD80-negative, CD81-positive, CD86-positive, CD95-positive, CD196-negative, CD229-positive, CD270-positive, CD352-positive, CD361-positive, and IgD-negative. Transcription factors: BLIMP1-positive, IRF4-positive, PAX5-negative, SpiB-negative, Ets1-negative, and XBP1-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "plasma B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasma B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasmacyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasmocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "effector B cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "effector B-cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000392"
        }, {
          "val" : "FMA:70574"
        }, {
          "val" : "MESH:D010950"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000787",
      "lbl" : "memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338", "http://en.wikipedia.org/wiki/Memory_B_cell" ]
        },
        "comments" : [ "Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000788",
      "lbl" : "naive B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A naive B cell is a mature B cell that has the phenotype surface IgD-positive, surface IgM-positive, CD20-positive, CD27-negative and that has not yet been activated by antigen in the periphery.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676", "PMID:20081059", "PMID:20839338", "PMID:20933013", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'naive B cell'. Per DSD: Naive B cells are also reportedly CD10-negative, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD25-negative, CD27-negative, CD34-negative, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD80-negative, CD81-positive, CD84-positive, CD86-negative, CD95-negative, CD138-negative, CD150-positive, CD184/CXCR4-positive, CD185/CXCR5-positive, CD196/CCR6-positive, CD200-positive, CD229-positive, CD243-positive, CD289-positive, CD290-positive, CD352-positive, MHCII/HLA-DR-positive, cadherin 9-positive, and sIgH-positive, Transcription factors: Pax5-positive, ETS1-positive, FOXO1A-positive, KLF4-positive, KLF9-positive, MiTF-positive, OBF1-positive, PLZF-positive, and SpiB-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000789",
      "lbl" : "alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that expresses an alpha-beta T cell receptor complex.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000790",
      "lbl" : "immature alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An alpha-beta T cell that has an immature phenotype and has not completed T cell selection.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000791",
      "lbl" : "mature alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A alpha-beta T cell that has a mature phenotype.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000792",
      "lbl" : "CD4-positive, CD25-positive, alpha-beta regulatory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, CD25-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149", "PMID:19464985", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'Treg'.  The inclusion of CD127lo in the logical definition is compatible with both human and mouse T cells of this subtype." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Treg",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CD25-positive, alpha-beta regulatory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000793",
      "lbl" : "CD4-positive, alpha-beta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that is found in the columnar epithelium of the gastrointestinal tract.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000794",
      "lbl" : "CD8-positive, alpha-beta cytotoxic T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell that is capable of killing target cells in an antigen specific manner with the phenotype perforin-positive and granzyme B-positive.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that while T cells of this subset are loosely referred to 'cytotoxic T cells,' as many other T cell types, including CD4-positive, alpha-beta T cells and gamma-delta T cells exhibit cytotoxicity in vitro and in vivo." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cytotoxic T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "cytotoxic T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "cytotoxic T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "cytotoxic T-lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "killer T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "killer T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "killer T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "killer T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytotoxic T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytotoxic T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytotoxic T-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0190"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000795",
      "lbl" : "CD8-positive, alpha-beta regulatory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell that regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8+ T(reg)"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8+ Treg"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8+ regulatory T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive T(reg)"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive Treg"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta Treg"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta regulatory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta regulatory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta regulatory T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000796",
      "lbl" : "CD8-alpha-beta-positive, alpha-beta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A alpha-beta intraepithelial T cell found in the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000797",
      "lbl" : "alpha-beta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature alpha-beta T cell of the columnar epithelium of the gastrointestinal tract. Intraepithelial T cells often have distinct developmental pathways and activation requirements.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alpha-beta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000798",
      "lbl" : "gamma-delta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that expresses a gamma-delta T cell receptor complex.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gammadelta T cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000799",
      "lbl" : "immature gamma-delta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A gamma-delta T cell that has an immature phenotype.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that gamma-delta T cells have both thymic and extrathymic differentiation pathways." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature gamma-delta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature gamma-delta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature gamma-delta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000800",
      "lbl" : "mature gamma-delta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A gamma-delta T cell that has a mature phenotype. These cells can be found in tissues and circulation where they express unique TCR repertoire depending on their location.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature gamma-delta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature gamma-delta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature gamma-delta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000801",
      "lbl" : "gamma-delta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature gamma-delta T cell that is found in the columnar epithelium of the gastrointestinal tract. These cells participate in mucosal immune responses.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-delta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000802",
      "lbl" : "CD8-alpha alpha positive, gamma-delta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A gamma-delta intraepithelial T cell that has the phenotype CD8-alpha alpha-positive.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, gamma-delta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, gamma-delta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, gamma-delta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000803",
      "lbl" : "CD4-negative CD8-negative gamma-delta intraepithelial T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A gamma-delta intraepithelial T cell that has the phenotype CD4-negative and CD8-negative.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "intraepithelial lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, gamma-delta intraepithelial T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, gamma-delta intraepithelial T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, gamma-delta intraepithelial T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000805",
      "lbl" : "immature single positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that has the phenotype CD4-negative, CD8-positive, CD44-negative, CD25-negative, and pre-TCR-positive.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and rearranging the T cell receptor alpha chain and expressing the CD8 coreceptor. This stage comes between the DN4 and DP stages." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ISP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T.ISP.th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature single positive T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature single positive T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature single positive T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000806",
      "lbl" : "DN2 thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-positive.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this type of thymocyte is at the earliest stage of T cell receptor rearrangement of the beta, gamma, and delta T cell receptor chains. Also, there is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DN2 alpha-beta immature T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN2 alpha-beta immature T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN2 alpha-beta immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN2 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN2 immature T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "TN2 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "TN2 thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative 2"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "preT.DN2.Th"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000807",
      "lbl" : "DN3 thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "early cortical thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN3 alpha-beta immature T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN3 alpha-beta immature T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN3 alpha-beta immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN3 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN3 immature T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "TN3 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "TN3 thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative 3"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "preT.DN3.Th"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000808",
      "lbl" : "DN4 thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, CD25-negative, and pre-TCR-positive.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this type of thymocyte has passed the beta-selection checkpoint and is rapidly proliferating and beginning to rearrange the T cell receptor alpha chain. There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "early cortical thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN4 alpha-beta immature T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN4 alpha-beta immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN4 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN4 immature T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN4 immature T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T.DN4.th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative 4"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000809",
      "lbl" : "double-positive, alpha-beta thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte expressing the alpha-beta T cell receptor complex as well as both the CD4 and CD8 coreceptors.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "Thymocytes of this stage are undergoing positive and negative selection." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "late cortical thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DP cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DP thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double-positive, alpha-beta immature T lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000810",
      "lbl" : "CD4-positive, alpha-beta thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature alpha-beta T cell that is located in the thymus and is CD4-positive and CD8-negative.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta immature T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta immature T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SP CD4 cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000811",
      "lbl" : "CD8-positive, alpha-beta thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature alpha-beta T cell that is located in the thymus and is CD8-positive and CD4-negative.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta immature T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta immature T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SP CD8 cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CD8-positive, alpha-beta immature T cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000813",
      "lbl" : "memory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A long-lived, antigen-experienced T cell that has acquired a memory phenotype including distinct surface markers and the ability to differentiate into an effector T cell upon antigen reexposure.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory T-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003435"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000814",
      "lbl" : "mature NK T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature alpha-beta T cell of a distinct lineage that bears natural killer markers and a T cell receptor specific for a limited set of ligands. NK T cells have activation and regulatory roles particularly early in an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature NK T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature NK T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature NK T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature NKT cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature natural killer T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature natural killer T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature natural killer T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature natural killer T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000815",
      "lbl" : "regulatory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031" ]
        },
        "comments" : [ "This cell type may express FoxP3 and CD25 and secretes IL-10 and TGF-beta." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "suppressor T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Treg"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulatory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulatory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulatory T-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004520"
        }, {
          "val" : "FMA:84070"
        }, {
          "val" : "MESH:D050378"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000816",
      "lbl" : "immature B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature B cell is a B cell that has the phenotype surface IgM-positive and surface IgD-negative, and have not undergone class immunoglobulin class switching or peripheral encounter with antigen and activation.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:20081059", "PMID:20839338" ]
        },
        "comments" : [ "Immature B cells are also reportedly CD5-positive, CD10-positive, CD19-positive, CD20-positive, CD21-positive, CD22-positive, CD24-positive, CD25-negative, CD27-negative, CD34-negative, CD38-positive, CD40-positive, CD43-negative, CD45-positive, CD48-positive, CD53-positive, CD79a-positive, CD80-negative, CD81-positive, CD86-negative, CD95-negative, CD127-negative, CD138-negative, CD185-positive, CD196-positive, MHCII/HLA-DR-positive, RAG-positive, TdT-negative, Vpre-B-negative, and preBCR-negative. Transcription factors expressed: Pax5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "newly formed B cell",
          "xrefs" : [ "ISBN:781735149" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000817",
      "lbl" : "precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor B cell is a B cell with the phenotype CD10-positive.",
          "xrefs" : [ "GOC:rhs", "GOC:tfm", "GO_REF:0000031" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "pre-B cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001133"
        }, {
          "val" : "CALOHA:TS-0819"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000818",
      "lbl" : "transitional stage B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage with the phenotype surface IgM-positive and CD19-positive, and are subject to the process of B cell selection. A transitional B cell migrates from the bone marrow into the peripheral circulation, and then to the spleen.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12810111", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'transitional B cell'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transitional B cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B-lymphocyte"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "T1 B cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "T2 B cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "T3 B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000819",
      "lbl" : "B-1 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B cell of distinct lineage and surface marker expression. B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas. These cells are CD43-positive.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GO_REF:0000031", "PMID:11861604", "PMID:20933013", "PMID:21220451", "http://en.wikipedia.org/wiki/B-1_cell" ]
        },
        "comments" : [ "There are small numbers of B-1 cells found in the lymph nodes and spleen, while larger numbers can be found in the peritoneal and pleural cavities. B-1 B cells are reportedly CD11b-positive, CD20-positive, CD21-positive, CD27-positive, CD44-positive, CD45RB-positive, CD48-positive, CD70-negative, CD150-positive, CD244-negative, CD352-positive, sIgM-positive, and sIgD-low." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1 B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1 cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000820",
      "lbl" : "B-1a B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B-1 B cell that has the phenotype CD5-positive.",
          "xrefs" : [ "GOC:add", "PMID:11861604" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1a B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1a B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1a B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1a B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1a cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD5(+) B1 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD5+ B1 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD5-positive B1 cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000821",
      "lbl" : "B-1b B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B-1 B cell that has the phenotype CD5-negative, but having other phenotypic attributes of a B-1 B cell.",
          "xrefs" : [ "GOC:add", "PMID:11861604" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1b B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1b B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1b B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1b B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B1b cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000822",
      "lbl" : "B-2 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells. These cells are CD43-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:11861604", "PMID:20933013" ]
        },
        "comments" : [ "B-2 B cells are reportedly CD48-positive, CD244-negative, and CD352-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-2 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-2 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-2 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B2 B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B2 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B2 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B2 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B2 cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "B-0 B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000823",
      "lbl" : "immature natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell that is developmentally immature and expresses natural killer cell receptors (NKR).",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ]
        },
        "comments" : [ "In mouse the NKR are Ly49 molecules and in human these cells express KIR molecules." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature NK cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "p-NK",
          "xrefs" : [ "PMID:12457618" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000824",
      "lbl" : "mature natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class I and other stress related molecules.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:14685782" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "LAK cell",
          "xrefs" : [ "PMID:14685782" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "lymphokine activated killer cell",
          "xrefs" : [ "PMID:14685782" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature NK cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000825",
      "lbl" : "pro-NK cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:11532393", "PMID:12457618", "PMID:15032583", "PMID:15766674" ]
        },
        "comments" : [ "Most markers only described for human pro NK cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "NKP",
          "xrefs" : [ "PMID:12457618", "PMID:15032583", "PMID:15766674" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "natural killer cell progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pro-natural killer cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "null cell",
          "xrefs" : [ "PMID:11532393" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "preNK cell",
          "xrefs" : [ "PMID:11532393" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000826",
      "lbl" : "pro-B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:12633665", "PMID:16551251", "PMID:18432934" ]
        },
        "comments" : [ "Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "pre-pro B cell",
          "xrefs" : [ "PMID:17582343" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pro-B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pro-B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pro-B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor B-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pre-B cell (Philadelphia nomenclature)",
          "xrefs" : [ "PMID:11244048" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003104"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000827",
      "lbl" : "pro-T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphoid progenitor cell of the T cell lineage, with some lineage specific marker expression, but not yet fully committed to the T cell lineage.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pro-T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor T cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DN1 cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DN1 thymocyte"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "TN1 cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000828",
      "lbl" : "thromboblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell of the thrombocyte, a nucleated blood cell involved in coagulation typically seen in birds and other non-mammalian vertebrates.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:7758949" ]
        },
        "comments" : [ "Note that this is a non-mammalian cell type." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000831",
      "lbl" : "mast cell progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell of the mast cell lineage. Markers for this cell are FceRIa-low, CD117-positive, CD9-positive, T1/ST2-positive, SCA1-negative, and lineage-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "PMCID:PMC1183570", "PMCID:PMC1312421", "PMID:8629001", "PMID:9354811", "http://www.copewithcytokines.de" ]
        },
        "comments" : [ "MCP are CD16-positive, CD32-positive, CD34-positive, CD45-positive, integrin beta-7-positive, and lin-negative (CD2, CD3e, CD4, CD5, CD8a, CD14, CD19, CD20, CD27, integrin alpha-M, ly6c, ly6g, NCAM-1, and ter119). These cells also express the transcription factors GATA-1, GATA-2, and MITF, but not C/EBPa." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MCP"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CFU-MC"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CFU-Mast"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit mast cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000834",
      "lbl" : "neutrophil progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell of the neutrophil lineage.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "neutrophil stem cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000835",
      "lbl" : "myeloblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The most primitive precursor in the granulocytic series, having fine, evenly distributed chromatin, several nucleoli, a high nuclear-to-cytoplasmic ration (5:1-7:1), and a nongranular basophilic cytoplasm. They reside in the bone marrow.",
          "xrefs" : [ "GOC:add", "ISBN:0721601464", "http://en.wikipedia.org/wiki/Myeloblast", "http://www.cap.org" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0000187"
        }, {
          "val" : "FMA:83524"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000837",
      "lbl" : "hematopoietic multipotent progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic multipotent progenitor cell is multipotent, but not capable of long-term self-renewal. These cells are characterized as lacking lineage cell surface markers and being CD34-positive in both mice and humans.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ]
        },
        "comments" : [ "Markers differ between mouse and human." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MPP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hemopoietic progenitor cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000725"
        }, {
          "val" : "CALOHA:TS-0448"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000838",
      "lbl" : "lymphoid lineage restricted progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell restricted to the lymphoid lineage.",
          "xrefs" : [ "GOC:add", "GOC:tfm" ]
        },
        "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "lymphoid progenitor cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004731"
        }, {
          "val" : "CALOHA:TS-2025"
        }, {
          "val" : "FMA:70338"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000839",
      "lbl" : "myeloid lineage restricted progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell restricted to the myeloid lineage.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "PMID:19022770" ]
        },
        "comments" : [ "Note that this is a class of cell types, not an identified single cell type." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "myeloid progenitor cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004730"
        }, {
          "val" : "CALOHA:TS-2099"
        }, {
          "val" : "FMA:70339"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000842",
      "lbl" : "mononuclear leukocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A leukocyte with a single non-segmented nucleus in the mature form.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mononuclear cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "peripheral blood mononuclear cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000878"
        }, {
          "val" : "CALOHA:TS-0768"
        }, {
          "val" : "FMA:86713"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000843",
      "lbl" : "follicular B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A resting mature B cell that has the phenotype IgM-positive, IgD-positive, CD23-positive and CD21-positive, and found in the B cell follicles of the white pulp of the spleen or the corticol areas of the peripheral lymph nodes. This cell type is also described as being CD19-positive, B220-positive, AA4-negative, CD43-negative, and CD5-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMCID:PMC2193793", "PMID:20933013", "http://en.wikipedia.org/wiki/Follicular_B_Cells" ]
        },
        "comments" : [ "Follicular B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Fo B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Fo B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "follicular B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "follicular B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "follicular B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000844",
      "lbl" : "germinal center B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0781735149", "PMID:19447676", "PMID:20933013" ]
        },
        "comments" : [ "Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GC B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GC B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GC B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GC B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "germinal center B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "germinal center B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "germinal center B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000845",
      "lbl" : "marginal zone B cell of spleen",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "ISBN:0781735149", "PMID:10933592", "PMID:20933013", "http://en.wikipedia.org/wiki/Marginal-zone_B_cell" ]
        },
        "comments" : [ "MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "MZ B cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "MZ B lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "MZ B-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "MZ B-lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "marginal zone B cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "marginal zone B lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "marginal zone B-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "marginal zone B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B cell of marginal zone of spleen"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "marginal zone of spleen B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000846",
      "lbl" : "vestibular dark cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the vestibular sensory organ that is characterized by intense enzymatic activities and numerous basal membrane infoldings.",
          "xrefs" : [ "PMID:11223304" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000847",
      "lbl" : "ciliated olfactory receptor neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An olfactory receptor cell in which the apical ending of the dendrite is a pronounced ciliated olfactory knob.",
          "xrefs" : [ "PMID:16841163" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ciliated olfactory sensory neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ciliated sensory neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000850",
      "lbl" : "serotonergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that releases serotonin as a neurotransmitter.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "5-HT neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "5-hydroxytryptamine neuron"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "serotinergic neuron"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D059326"
        }, {
          "val" : "WBbt:0006837"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000853",
      "lbl" : "olfactory epithelial supporting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Olfactory epithelial support cell is a columnar cell that extends from the epithelial free margin to the basement membrane of the olfactory epithelium. This cell type has a large, vertically, elongate, euchromatic nucleus, along with other nuclei, forms a layer superficial to the cell body of the receptor cell; sends long somewhat irregular microvilli into the mucus layer; at the base, with expanded end-feet containing numerous lamellated dense bodies resembling lipofuscin of neurons.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "olfactory epithelial support cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory sustentacular cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "supporting cell of olfactory epithelium"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sustentaculocyte of olfactory epithelium"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62302"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000855",
      "lbl" : "sensory hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Hair cell is a mechanoreceptor cell that is sensitive to movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system.",
          "xrefs" : [ "SANBI:mhl" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "hair cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004744"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000856",
      "lbl" : "neuromast hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.",
          "xrefs" : [ "SANBI:mhl" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000860",
      "lbl" : "classical monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A monocyte that responds rapidly to microbial stimuli by secreting cytokines and antimicrobial factors and which is characterized by high expression of CCR2 in both rodents and humans, negative for the lineage markers CD3, CD19, and CD20, and of larger size than non-classical monocytes.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "PMID:16322748", "PMID:18303997", "PMID:20628149", "PMID:20870168" ]
        },
        "comments" : [ "Markers: CCR2+CXCCR1<low> (human, mouse, rat)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "inflammatory monocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000864",
      "lbl" : "tissue-resident macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A macrophage constitutively resident in a particular tissue under non-inflammatory conditions, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.",
          "xrefs" : [ "GOC:ana", "GO_REF:0000031", "PMID:19770654" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "fixed macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "resting histiocyte"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84642"
        }, {
          "val" : "FMA:84644"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000878",
      "lbl" : "central nervous system macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage found in the central nervous system.",
          "xrefs" : [ "GO_REF:0000031", "PMID:16322748" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CNS macrophage"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000881",
      "lbl" : "perivascular macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A border associated macrophage that is adjacent to a small blood vessel of a brain. A perivascular macrophage expresses the markers CD14, CD16 and CD163. In homeostatic conditions, this central nervous system macrophage has a non-motile cell body with extending and retracting projections through the blood vessel wall.",
          "xrefs" : [ "GOC:tfm", "GO_REF:0000031", "PMID:16507898", "PMID:37232741" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000889",
      "lbl" : "myeloid suppressor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature myeloid leukocyte of heterogeneous phenotype found particularly in cancer and sepsis patients that is capable of suppressing activity of T cells in ex vivo assays. This cell type is CD45-positive, CD11b-positive.",
          "xrefs" : [ "GOC:add", "GOC:ana", "GO_REF:0000031", "PMID:16168663", "PMID:17016554", "PMID:17016559" ]
        },
        "comments" : [ "Markers: Mouse: CD11b+GR1+CD31+; Human: CD34+ CD33+CD15-CD13+. (According to some reports in humans these cells are iNOS+ARG1+IL13+IFNg+); location: In cancerous tissue; in the blood and lymphoid organs in sepsis." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000891",
      "lbl" : "foam cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of cell containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions.",
          "xrefs" : [ "GOC:add" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0003872"
        }, {
          "val" : "FMA:83586"
        }, {
          "val" : "MESH:D005487"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000893",
      "lbl" : "thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature T cell located in the thymus.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:12415312" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "immature T cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "immature T lymphocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "immature T-cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "immature T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "thymic lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001372"
        }, {
          "val" : "CALOHA:TS-1042"
        }, {
          "val" : "FMA:72202"
        }, {
          "val" : "MESH:D060168"
        }, {
          "val" : "XAO:0003159"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000894",
      "lbl" : "DN1 thymic pro-T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pro-T cell that has the phenotype CD4-negative, CD8-negative, CD44-positive, and CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DN1 thymic pro-T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN1 thymic pro-T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN1 thymic pro-T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN1 thymic progenitor T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DN1 thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative 1"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "preT.DN1.Th"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000895",
      "lbl" : "naive thymus-derived CD4-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An antigen inexperienced CD4-positive, alpha-beta T cell with the phenotype CCR7-positive, CD127-positive and CD62L-positive. This cell type develops in the thymus. This cell type is also described as being CD25-negative, CD62L-high, and CD44-low.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "PMID:19100699", "PMID:22343568", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "These cells have not been exposed to antigen following thymic T-cell selection; found in blood and secondary lymphoid organs. This cell type is compatible with the HIPC Lyoplate markers for 'naive CD4+ T cell', but includes additional markers known to be expressed on naive CD4+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "naive CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T.4Nve.Sp"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th0",
          "xrefs" : [ "GOC:tfm" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-derived CD4-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-derived CD4-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-derived CD4-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000896",
      "lbl" : "activated CD4-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A recently activated CD4-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "activated CD4-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "activated CD4-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "activated CD4-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000897",
      "lbl" : "CD4-positive, alpha-beta memory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that has differentiated into a memory T cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "T4.Mem.Sp"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000898",
      "lbl" : "naive T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Mature T cell not yet exposed to antigen with the phenotype CCR7-positive, CD45RA-positive, and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19100699" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "naive T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000899",
      "lbl" : "T-helper 17 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD4-positive, alpha-beta T cell with the phenotype RORgamma-t-positive, CXCR3-negative, CCR6-positive, and capable of producing IL-17.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:20303875", "PMID:20969597", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'Th17 CD4+ T cell', but its logical definition includes additional known characteristics of T-helper 17 T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IL-17-producing CD4+ T helper"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T helper cells type 17"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T(H)-17 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T cell type 17"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D058504"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000900",
      "lbl" : "naive thymus-derived CD8-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell that has not experienced activation via antigen contact and has the phenotype CD45RA-positive, CCR7-positive and CD127-positive. This cell type is also described as being CD25-negative, CD62L-high and CD44-low.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:22343568", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "This cell traffics in secondary lymphoid organs and blood.  This cell type is compatible with the HIPC Lyoplate markers for 'naive CD8+ T cell', but includes additional markers known to be expressed on naive CD8+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "naive CD8+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-dervied CD8-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-dervied CD8-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "naive thymus-dervied CD8-positive, alpha-beta T-lymphocyte"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "T.8Nve.Sp"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000904",
      "lbl" : "central memory CD4-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD4+ T cell', but includes additional markers known to be expressed on central memory CD4+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "central memory CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD4-positive, alpha-beta memory T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD4-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD4-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD4-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD4-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD4-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD4-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000905",
      "lbl" : "effector memory CD4-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD4-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD4+ T cell', but includes additional markers known to be expressed on effector memory CD4+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "effector memory CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD4-positive, alpha-beta memory T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD4-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD4-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD4-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD4-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD4-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD4-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000906",
      "lbl" : "activated CD8-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, CD25-positive, and CCR7-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "activated CD8-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "activated CD8-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "activated CD8-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000907",
      "lbl" : "central memory CD8-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-positive, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'central memory CD8+ T cell', but includes additional markers known to be expressed on central memory CD8+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "central memory CD8+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD8-positive, alpha-beta memory T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD8-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD8-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central CD8-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD8-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD8-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central memory CD8-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000908",
      "lbl" : "CD8-positive, alpha-beta cytokine secreting effector T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell with the phenotype CD69-positive, CD62L-negative, CD127-negative, and CD25-positive, that secretes cytokines.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:20146720" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytokine secreting effector T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytokine secreting effector T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta cytokine secreting effector T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000909",
      "lbl" : "CD8-positive, alpha-beta memory T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell that has differentiated into a memory T cell.",
          "xrefs" : [ "GOC:add", "PMID:20146720" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "T.8Mem.Sp"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000911",
      "lbl" : "effector T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response.",
          "xrefs" : [ "GOC:PAM-ADD", "GOC:tfm", "ISBN:0877799148", "PMID:18395547" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "effector T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000912",
      "lbl" : "helper T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A effector T cell that provides help in the form of secreted cytokines to other immune cells.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:18395547" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T-helper cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "helper T-lymphocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002417"
        }, {
          "val" : "MESH:D006377"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000913",
      "lbl" : "effector memory CD8-positive, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD8-positive, alpha-beta memory T cell with the phenotype CCR7-negative, CD127-positive, CD45RA-negative, CD45RO-positive, and CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:20146720", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'effector memory CD8+ T cell', but includes additional markers known to be expressed on effector memory CD8+ T cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "effector memory CD8+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD8-positive, alpha-beta memory T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD8-positive, alpha-beta memory T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD8-positive, alpha-beta memory T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector CD8-positive, alpha-beta memory T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD8-positive, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD8-positive, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "effector memory CD8-positive, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000914",
      "lbl" : "immature NK T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature alpha-beta T-cell that express Egr2. These cells give rise to T cells expressing NK markers.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:17589542", "PMID:19169262" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature NK T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature NK T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature NK T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature NKT cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000916",
      "lbl" : "dendritic epidermal T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature gamma-delta T cell located in the epidermis that regulates wound healing.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:11976459" ]
        },
        "comments" : [ "In mice, DETC have an invariant T cell receptor." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DETC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dendritic epidermal T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dendritic epidermal T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dendritic epidermal T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000936",
      "lbl" : "early lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphoid progenitor cell that is found in bone marrow, gives rise to B cells, T cells, natural killer cells and dendritic cells, and has the phenotype Lin-negative, Kit-positive, Sca-1-positive, FLT3-positive, CD34-positive, CD150 negative, and GlyA-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:19022770" ]
        },
        "comments" : [ "Markers are associated with mouse cells. ELP transcription factors include E2A-positive, Ikaros-positive, EBF-negative, Pax5-negative, PU.1-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lymphoid-primed multipotent progenitor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000937",
      "lbl" : "pre-natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell committed to natural killer cell lineage that has the phenotype CD122-positive, CD34-positive, and CD117-positive. This cell type lacks expression of natural killer receptor proteins.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:pam", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17100874" ]
        },
        "comments" : [ "These cells are also reportedly CD7-low, CD10-negative, CD45RA-positive, alpha-4-beta-7 integrin-high." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pre-NK cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000941",
      "lbl" : "thymic conventional dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dendritic cell arising in thymus that has the phenotype CD11c-positive, CD11b-negative, and CD45RA-negative.",
          "xrefs" : [ "GOC:add", "GOC:pam", "GO_REF:0000031", "PMID:19273629" ]
        },
        "comments" : [ "In the mouse this cell expresses CD8-alpha-alpha." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000945",
      "lbl" : "lymphocyte of B lineage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte of B lineage with the commitment to express an immunoglobulin complex.",
          "xrefs" : [ "GOC:add", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149" ]
        },
        "comments" : [ "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells).  Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000946",
      "lbl" : "antibody secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte of B lineage that is devoted to secreting large amounts of immunoglobulin.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0721601464", "ISBN:0781735149" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000948",
      "lbl" : "IgE memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class switched memory B cell that expresses IgE on the cell surface.",
          "xrefs" : [ "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgE memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgE memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgE memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgE B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgE B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgE B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgE B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000952",
      "lbl" : "preBCR-positive large pre-B-II cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An preBRC-positive large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-positive, composed of surrogate light chain protein (SL), which is composed of VpreB , Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu) on the cell surface.",
          "xrefs" : [ "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000953",
      "lbl" : "preBCR-negative large pre-B-II cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-BCR-negative large pre-B-II cell is a large pre-B-II cell that is pre-B cell receptor-negative, composed of surrogate light chain protein (SL), which is composed of VpreB and Lambda 5/14.1, in complex with immunoglobulin mu heavy chain (IgHmu), on the cell surface, and lack a DNA rearrangement of immunoglobulin light chain genes.",
          "xrefs" : [ "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000954",
      "lbl" : "small pre-B-II cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small pre-B-II cell is a pre-B-II cell that is Rag1-positive, Rag2-positive, pre-BCR-negative, and BCR-negative, is not proliferating, and carries a DNA rearrangement of one or more immunoglobulin light chain genes.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ]
        },
        "comments" : [ "Small pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-negative, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "small pre-BII cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000955",
      "lbl" : "pre-B-II cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-B-II cell is a precursor B cell that expresses immunoglobulin mu heavy chain (IgHmu+), and lack expression of CD34, TdT, immunoglobulin kappa light chain and immunoglobulin lambda light chain.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:9785673" ]
        },
        "comments" : [ "pre-B-II cell are also reportedly CD19-positive, CD22-positive, CD38-positive, CD45-positive, and CD48-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pre-B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pre-BII cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001133"
        }, {
          "val" : "CALOHA:TS-0819"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000956",
      "lbl" : "pre-B-I cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-B-I cell is a precursor B cell that expresses CD34 and surrogate immunoglobulin light chain (VpreB , Lambda 5 (mouse)/14.1 (human)) on the cell surface, and TdT, Rag1,and Rag2 intracellularly. Cell type carries a D-JH DNA rearrangement, and lacks expression of immunglobulin heavy chain protein.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:20839338", "PMID:9785673" ]
        },
        "comments" : [ "Human pre-B-I cells are reportedly CD10-positive, CD19-positive, CD22-positive, CD38-positive, CD45-low, CD79a-positive, CD127-negative, pre-BCR-negative, IgM-negative, IgD-negative, and Tdt-positive. Transcription factors expressed: Pax5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pre-BI cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pro-B cell (Philadelphia nomenclature)",
          "xrefs" : [ "PMID:11244048" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000957",
      "lbl" : "large pre-B-II cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A large pre-B-II cell is a pre-B-II cell that is proliferating and is Rag1-negative and Rag2-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "PMID:16551251", "PMID:18432934", "PMID:9785673" ]
        },
        "comments" : [ "Large pre-B-II cells are also reportedly CD10-positive, CD19-positive, CD34-negative, CD79a-positive, CD127-negative, TdT-negative, Vpre-B-positive, pre-BCR-positive, sIgM-negative, and sIgD-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "large pre-B cell",
          "xrefs" : [ "PMID:11244048" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "large pre-BII cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000958",
      "lbl" : "T1 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional stage B cell that migrates from the bone marrow into the peripheral circulation, and finally to the spleen. This cell type has the phenotype surface IgM-positive, surface IgD-negative, CD21-negative, CD23-negative, and CD62L-negative, and CD93-positive. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ]
        },
        "comments" : [ "T1 B cells are also reportedly CD10-negative/positive??, CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T1 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T1 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T1 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage 1 B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000959",
      "lbl" : "T2 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional stage B cell that has the phenotype surface IgM-positive, surface IgD-postive, CD21-positive, CD23-positive, CD62L-negative, CD93-positive and is located in the splenic B follicles. This cell type has also been described as IgM-high, CD19-positive, B220-positive, AA4-positive, and CD23-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2193793", "PMID:12810111" ]
        },
        "comments" : [ "T2 B cells are also reportedly CD20-positive, CD24-positive, CD38-positive, CD48-positive, CD84-positive, CD150-positive, CD244-negative, and CD352-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T2 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T2 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T2 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage 2 B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000960",
      "lbl" : "T3 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional stage B cell that expresses surface IgM and IgD, and CD62L. This cell type appears to be an anergic B cell that does not proliferate upon BCR signaling, is found in the spleen and lymph nodes, and has the phenotype surface IgM-positive, surface IgD-positive, CD21-positive, CD23-positive, CD62L-positive, and CD93-positive. This cell type has also been described as IgM-low, CD19-positive, B220-positive, AA4-positive, and CD23-positive (i.e. this cell-type is distinguished from T2 cells by surface expression of IgM).",
          "xrefs" : [ "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:12810111", "PMID:17174121", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "An1 B cell",
          "xrefs" : [ "PMID:17174121" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T3 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T3 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T3 B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage 3 B cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000961",
      "lbl" : "Bm1 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A follicular B cell that is IgD-positive, CD23-negative, and CD38-negative. This naive cell type is activated in the extrafollicular areas through interaction with interdigitating dendritic cells and antigen-specific CD4-positive T cells.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:11564773", "PMID:17992590", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "These cells are also reportedly CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm1 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm1 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm1 B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000962",
      "lbl" : "Bm2 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A follicular B cell that is IgD-positive and CD23-positive and CD38-positive. This naive cell type is activated in the extrafollicular areas via interaction with dendritic cells and antigen specific T cells.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:11564773", "PMID:17992590", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "These cells are also CD10-negative, CD39-positive, CD44-positive, CD71-negative, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm2 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm2 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm2 B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000963",
      "lbl" : "Bm3-delta B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A germinal center B cell that develops from a Bm3 B cell. This cell has the phenotype IgM-negative, IgD-positive, and CD38-positive.",
          "xrefs" : [ "GOC:add", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:9280752" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm3-delta B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm3-delta B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm3-delta B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000964",
      "lbl" : "Bm2' B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A germinal center B cell that founds a germinal center, and has the phenotype IgD-positive, CD38-positive, and CD23-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:11564773", "PMID:17992590", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "Bm2' B cells are also reportedly CD10-positive, CD39-negative, CD44-negative, CD71-positive, CD77-negative, IgM-positive, IgG-negative, IgA-negative, and IgE-negative." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm2' B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm2' B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm2-prime B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm2-prime B-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "germinal center founder cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000965",
      "lbl" : "Bm3 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A germinal center B cell that is rapidly dividing and has the phenotype IgD-negative, CD38-positive, and CD77-positive. Somatic hypermutation of the immunoglobulin V gene region can occur during proliferation of this cell type.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:11564773", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "Bm3 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-negative, CD71-positive, and CD77-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm3 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm3 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm3 B-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "centroblast",
          "xrefs" : [ "PMID:8006591" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000966",
      "lbl" : "Bm4 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A germinal center B cell that has the phenotype CD77-negative, IgD-negative, and CD38-positive. These cells have undergone somatic mutation of the B cell receptor.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GO_REF:0000031", "PMID:11564773", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "Bm4 B cells are also reportedly CD10-positive, CD23-negative, CD39-negative, CD44-positive, and CD71-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm4 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm4 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm4 B-lymphocyte"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "centrocyte",
          "xrefs" : [ "PMID:17992590" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000967",
      "lbl" : "Bm5 B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A memory B cell arising in the germinal center that is IgD-negative and has undergone somatic mutation of the variable region of the immunoglobulin heavy and light chain genes.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMID:11564773", "PMID:18432934", "PMID:19350211", "PMID:31681331", "PMID:8006591" ]
        },
        "comments" : [ "Bm5 B cells are also reportedly CD10-positive, CD23-negative, CD38-negative, CD39-positive, CD44-positive, CD71-positive, and CD77-negative." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bm5 B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm5 B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bm5 B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000970",
      "lbl" : "unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An unswitched memory B cell is a memory B cell that has the phenotype IgM-positive, IgD-positive, CD27-positive, CD138-negative, IgG-negative, IgE-negative, and IgA-negative.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'IgD+ memory B cell'. Per DSD: Unswitched memory B cells are also reportedly CD48-positive, CD84-positive, CD229-positive, and CD352-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "IgD+ memory B cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "non-class-switched memory B cell",
          "xrefs" : [ "HP:0032126" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "unswitched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "unswitched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "unswitched memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000971",
      "lbl" : "IgM memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgM memory B cell is an unswitched memory B cell with the phenotype IgM-positive and IgD-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:19447676" ]
        },
        "comments" : [ "IgM memory B cells are also reportedly CD1c-positive, CD95-positive, CD80-positive, CD84-positive, CD86-positive, CD150-negative, CD229-positive, CD289-positive, and CD290-positive. Transcription factors: Notch2-positive, PAX5-positive, SpiB-positive, Ets1-positive, and OBF1-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgM memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgM memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgM memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgM B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgM B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgM B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgM B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000972",
      "lbl" : "class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class switched memory B cell is a memory B cell that has undergone Ig class switching and therefore is IgM-negative on the cell surface. These cells are CD27-positive and have either IgG, IgE, or IgA on the cell surface.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196", "PMID:20933013", "PMID:9295047" ]
        },
        "comments" : [ "Per DSD: Class switched memory B cells are also reportedly CD48-positive, CD229-positive, and CD352-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "class switched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "class switched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "class switched memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000973",
      "lbl" : "IgA memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class switched memory B cell that expresses IgA.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GO_REF:0000031", "ISBN:0781765196" ]
        },
        "comments" : [ "IgA memory B cell are also reportedly RORalpha-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgA memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgA memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgA memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgA B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgA B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgA B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgA B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000974",
      "lbl" : "long lived plasma cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fully differentiated plasma cell that lives for years, as opposed to months, secretes immunoglobulin, and has the phenotype weakly CD19-positive, CD20-negative, CD38-negative, strongly CD138-positive, MHC Class II-negative, surface immunoglobulin-negative, IgD-negative, and strongly CXCR4-positive. The majority of these cells of this type reside in the bone marrow.",
          "xrefs" : [ "GOC:msz", "GOC:tfm", "GO_REF:0000031", "ISBN:9780781765190", "PMID:16014527" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000975",
      "lbl" : "short lived plasma cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fully differentiated plasma cell that lives for months.",
          "xrefs" : [ "GOC:msz", "GO_REF:0000031", "PMID:16014527" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000979",
      "lbl" : "IgG memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgG memory B cell is a class switched memory B cell that is class switched and expresses IgG on the cell surface.",
          "xrefs" : [ "GOC:rhs", "GO_REF:0000031", "ISBN:0781765196" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgG memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgG B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgG B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgG B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "memory IgG B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000980",
      "lbl" : "plasmablast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:msz", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2673126" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "CD20-negative B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD27-positive, CD38-positive, CD20-negative B cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84371"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000981",
      "lbl" : "double negative memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A memory B cell with the phenotype IgD-negative and CD27-negative.",
          "xrefs" : [ "GOC:msz", "GOC:tfm", "GO_REF:0000031" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "dn memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dn memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dn memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dn memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000988",
      "lbl" : "hematopoietic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of a hematopoietic lineage.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "haematopoietic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "haemopoietic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hemopoietic cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000574"
        }, {
          "val" : "CALOHA:TS-2017"
        }, {
          "val" : "FMA:70366"
        }, {
          "val" : "FMA:83598"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000990",
      "lbl" : "conventional dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Conventional dendritic cell is a dendritic cell that is CD11c-high.",
          "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:17850486" ]
        },
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:0000003)(PMID:19243617) These cells are also CD20-negative, MHCII-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "interdigitating cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "veiled cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DC1"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cDC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dendritic reticular cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 1 DC"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84191"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0000995",
      "lbl" : "CD34-positive, CD38-positive common myeloid progenitor OR CD34-positive, CD38-positive common lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1100000)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "CD71-positive common myeloid precursor OR CD7-negative lymphoid precursor OR CD7-positive lymphoid"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001008",
      "lbl" : "Kit and Sca1-positive hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell that has plasma membrane part Kit-positive, SCA-1-positive, CD150-positive and CD34-negative.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "PMID:19022770" ]
        },
        "comments" : [ "Cell markers are associated with mouse hematopoietic stem cell. Originally described in the dendritic cell ontology (DC_CL:0000043)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "LSK stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Sca1-positive hematopoietic stem cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001012",
      "lbl" : "CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1110000)(PMID:19243617)." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001019",
      "lbl" : "CD115-positive monocyte OR common dendritic progenitor",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111000)(PMID:19243617)." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001021",
      "lbl" : "CD34-positive, CD38-positive common lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A common lymphoid progenitor that is CD10-positive, CD45RA-positive, CD34-positive and CD38-positive.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMCID:PMC2346585", "PMID:19022770" ]
        },
        "comments" : [ "These markers are associated with human common lymphoid progenitors. Originally described in the dendritic cell ontology (DC_CL:0000032)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD10-positive common lymphocyte precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD10-positive common lymphocyte progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD10-positive common lymphoid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001022",
      "lbl" : "CD115-positive monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD115-positive monocyte is a monocyte that is CD115-positive and CD11b-positive.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMID:17952047" ]
        },
        "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000033)(PMID:19243617)." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001023",
      "lbl" : "Kit-positive, CD34-positive common myeloid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A common myeloid progenitor that is Kit-positive and CD34-positive, Il7ra-negative, and is SCA1-low and Fcgr2-low and Fcgr3-low.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:1261582", "PMID:17952047", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers are associated with mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000034)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "CD117-positive common myeloid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001024",
      "lbl" : "CD34-positive, CD38-negative hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD133-positive hematopoietic stem cell is a hematopoietic stem cell that is CD34-positive, CD90-positive, and CD133-positive.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:10430905", "PMID:11750107", "PMID:16551251", "PMID:20024907", "PMID:9389721" ]
        },
        "comments" : [ "Cell markers are associated with human hematopoietic stem cells. Originally described in the dendritic cell ontology (DC_CL:0000035)(PMID:19243617)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD133-positive hematopoietic stem cell",
          "xrefs" : [ "PMID:16140871" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0448"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001025",
      "lbl" : "Kit-positive, Sca1-positive common lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A common lymphoid progenitor that is Kit-low, FLT3-positive, IL7ralpha-positive, and SCA1-low.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:17952047", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD217-positive common lymphocyte precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD217-positive common lymphocyte progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD217-positive common lymphoid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001026",
      "lbl" : "CD34-positive, CD38-positive common myeloid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A common myeloid progenitor that is CD34-positive, CD38-positive, IL3ra-low, CD10-negative, CD7-negative, CD45RA-negative, and IL-5Ralpha-negative.",
          "xrefs" : [ "GOC:add", "GOC:amm", "GO_REF:0000031", "PMCID:PMC2626675", "PMID:16551251" ]
        },
        "comments" : [ "Markers are associated with human cell type. Originally described in the dendritic cell ontology (DC_CL:0000038)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "CD71-positive common myeloid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001027",
      "lbl" : "CD7-negative lymphoid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD7-negative lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-negative and CD45RA-negative.",
          "xrefs" : [ "GOC:amm", "GO_REF:0000031", "PMID:16551251" ]
        },
        "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000039)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD7-negative lymphoid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001028",
      "lbl" : "CD7-positive lymphoid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD7-positive lymphoid progenitor cell is a lymphoid progenitor cell that is CD34-positive, CD7-positive and is CD45RA-negative.",
          "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:19491395" ]
        },
        "comments" : [ "These markers are associated with human cells. Originally described in the dendritic cell ontology (DC_CL:0000040)(PMID:19243617)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD7-positive lymphoid precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001029",
      "lbl" : "common dendritic progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Common dendritic precursor is a hematopoietic progenitor cell that is CD117-low, CD135-positive, CD115-positive and lacks plasma membrane parts for hematopoietic lineage markers.",
          "xrefs" : [ "GOC:amm", "GOC:tfm", "GO_REF:0000031", "PMID:16551251", "PMID:17922016", "PMID:19286519" ]
        },
        "comments" : [ "Surface markers are for mouse cells. Originally described in the dendritic cell ontology (DC_CL:0000041) CDP are reportedly CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD11c-positive, CD14-negative, CD19-negative, CD20-negative, CD56-negative, B220-negative, Ly6g-negative, MHCII-positive, and Ter119-negative. (PMID:19243617)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CDP",
          "xrefs" : [ "PMID:21219184" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "common dendritic precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pro-DCs",
          "xrefs" : [ "PMID:21219184" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001030",
      "lbl" : "CD117-positive common myeloid progenitor OR CD217-positive common lymphoid progenitor",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Originally described in the dendritic cell ontology (DC_CL:1111100)(PMID:19243617)." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001031",
      "lbl" : "cerebellar granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. A mature cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers.",
          "xrefs" : [ "GOC:mah", "doi:10.12688/f1000research.15021.1", "doi:10.3389/fncir.2020.611841" ]
        },
        "comments" : [ "It has been noted in at least some mammalian species that granule cells are the most numerous cell type in the cerebellum and in the brain, with at least 99% of all cerebellar neurons being granule cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "granule cell of the cerebellum",
          "xrefs" : [ "doi:10.3389/fncir.2020.611841" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004278"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001032",
      "lbl" : "cortical granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Granule cell that is part of the cerebral cortex.",
          "xrefs" : [ "GOC:mah" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001033",
      "lbl" : "hippocampal granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Granule cell with a soma found in the hippocampus.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001035",
      "lbl" : "bone cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A connective tissue cell found in bone.",
          "xrefs" : [ "GOC:add", "GO_REF:0000034" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-11-16T04:28:16Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001040",
      "lbl" : "non-terminally differentiated osteoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Osteoblast that is non-terminally differentiated and located in cellular bone tissue or under the periosteum in acellular bone.",
          "xrefs" : [ "VSAO:curator" ]
        },
        "comments" : [ "VSAO relationship simplified OBO_REL:integral_part_of VSAO:0000118" ],
        "xrefs" : [ {
          "val" : "VSAO:0000117"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001051",
      "lbl" : "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-negative.",
          "xrefs" : [ "GOC:add", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'non-Th1/Th17 CD4+ T cell'.  Cells of this phenotype may include T-helper 2 T cells and some naive CD4+ T cells." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "non-Th1/Th17 CD4+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, CXCR3-negative, CCR6-negative, alpha-beta T-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001053",
      "lbl" : "IgD-negative memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A memory B cell that lacks expression of surface IgD.",
          "xrefs" : [ "GOC:add", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'IgD- memory B cell'.  The majority of these cells are class-switched, though some are IgM-positive." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgD- memory B cell",
          "xrefs" : [ "PMID:22343568" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001054",
      "lbl" : "CD14-positive monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A monocyte that expresses CD14 and is negative for the lineage markers CD3, CD19, and CD20.",
          "xrefs" : [ "GOC:add", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'monocyte'. Note that while CD14 is considered a reliable marker for human monocytes, it is only expressed on approximately 85% of mouse monocytes." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "monocyte",
          "xrefs" : [ "PMID:22343568" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001055",
      "lbl" : "CD14-positive, CD16-low monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intermediate monocyte that is CD14-positive and with low amounts of CD16.",
          "xrefs" : [ "GOC:add", "PMID:20628149" ]
        },
        "comments" : [ "Definition is valid for human intermediate monocytes." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intermediate monocyte, human"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001059",
      "lbl" : "common myeloid progenitor, CD34-positive",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell committed to myeloid lineage, including the megakaryocyte and erythroid lineages. These cells are CD34-positive, and express Gata1, Gata2, C/EBPa, and Pu.1.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "ISBN:0878932437", "PMCID:PMC2212039", "PMID:10724173", "PMID:16551251", "PMID:16647566" ]
        },
        "comments" : [ "CMP are reportedly CD16-positive, CD32-positive, CD38-positive, CD45RA-negative, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "common myeloid precursor, CD34-positive"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit granulocyte, erythrocyte, macrophage, and megakaryocyte",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "multipotential myeloid stem cell",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "myeloid stem cell",
          "xrefs" : [ "ISBN:0878932437" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pluripotent stem cell (bone marrow)",
          "xrefs" : [ "ISBN:0878932437" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001060",
      "lbl" : "hematopoietic oligopotent progenitor cell, lineage-negative",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities. Cell lacks hematopoeitic lineage markers.",
          "xrefs" : [ "GOC:tfm", "PMID:19022770" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-06T03:43:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001065",
      "lbl" : "innate lymphoid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte that lacks characteristic T cell, B cell, myeloid cell, and dendritic cell markers, that functions as part of the innate immune response to produce cytokines and other effector responses.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "PMID:23292121", "PMID:23348417" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2017-01-30T20:20:48Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001066",
      "lbl" : "erythroid progenitor cell, mammalian",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell committed to the erythroid lineage. This cell is ter119-positive but lacks expression of other hematopoietic lineage markers (lin-negative).",
          "xrefs" : [ "GOC:add", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "blast forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "burst forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "colony forming unit erythroid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "erythroid stem cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004911"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001067",
      "lbl" : "group 1 innate lymphoid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An innate lymphoid cell that is capable of producing the type 1 cytokine IFN-gamma, but not Th2 or Th17 cell-associated cytokines.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "PMID:23348417" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2017-01-30T20:42:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001070",
      "lbl" : "beige adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is beige in color, thermogenic, and which differentiates in white fat tissue from a Myf5-negative progenitor.",
          "xrefs" : [ "GOC:add", "GOC:cvs", "GOC:ymb", "PMID:22796012", "PMID:25851693" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "beige brown adipocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "beige fat cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "beige/brite adipocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brite adipocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brite cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brite fat cell"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D000069797"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001072",
      "lbl" : "CD34-negative, CD117-positive innate lymphoid cell, human",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An innate lymphoid cell in the human with the phenotype CD34-negative, CD117-positive, and a precusor to NK cells, ILC2 cells, and ILC3 cells.",
          "xrefs" : [ "GOC:add", "PMID:30193847", "PMID:31201208" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD117-positive ILC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD117-positive ILCP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD117-positive innate lymphoid cell precusor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001073",
      "lbl" : "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell, human",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An innate lymphoid cell in the human with the phenotype CD34-negative, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells.",
          "xrefs" : [ "GOC:add", "PMID:30193847", "PMID:31201208" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD56-positive, CD117-positive ILC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD56-positive, CD117-positive ILCP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD34-negative, CD56-positive, CD117-positive innate lymphoid cell precursor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001074",
      "lbl" : "CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An innate lymphoid cell precursor in the human with the phenotype CD34-positive, CD56-positive, CD117-positive.Thie cell type may include precusors to NK cells and ILC3 cells.",
          "xrefs" : [ "GOC:add", "PMID:30193847" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD34-positive, CD56-positive, CD117-positive CILP"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001082",
      "lbl" : "immature innate lymphoid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An innate lyphoid cell with an immature phenotype.",
          "xrefs" : [ "GOC:add" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature ILC"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001200",
      "lbl" : "lymphocyte of B lineage, CD19-positive",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte of B lineage that is CD19-positive.",
          "xrefs" : [ "GOC:add" ]
        },
        "comments" : [ "Types of B lineage lymphocytes include B cells and antibody secreting cells (plasmablasts and plasma cells).  Lymphocytes of B cell lineage can be distinguished from those of T cell lineage by their lack of CD3e (as part of the T cell receptor complex)." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001201",
      "lbl" : "B cell, CD19-positive",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B cell that is CD19-positive.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte, CD19-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell, CD19-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte, CD19-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD19+ B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD19-positive B cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9990-8331"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001203",
      "lbl" : "CD8-positive, alpha-beta memory T cell, CD45RO-positive",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell with memory phenotype indicated by being CD45RO and CD127-positive. This cell type is also described as being CD25-negative.",
          "xrefs" : [ "GOC:tfm", "GO_REF:0000031", "PMID:20146720", "PMID:21926977", "PMID:24258910" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T lymphocyte, CD45RO-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T-cell, CD45RO-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive, alpha-beta memory T-lymphocyte, CD45RO-positive"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0001204",
      "lbl" : "CD4-positive, alpha-beta memory T cell, CD45RO-positive",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD4-positive, alpha-beta long-lived T cell with the phenotype CD45RO-positive and CD127-positive. This cell type is also described as being CD25-negative.",
          "xrefs" : [ "GOC:add", "GOC:tfm", "GO_REF:0000031", "ISBN:0781735149", "PMID:21926977", "PMID:24258910", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T lymphocyte, CD45RO-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T-cell, CD45RO-positive"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD4-positive, alpha-beta memory T-lymphocyte, CD45RO-positive"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002000",
      "lbl" : "Kit-positive erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An erythroid progenitor cell is Kit-positive, Ly6A-negative, CD41-negative, CD127-negative, and CD123-negative. This cell type is also described as being lin-negative, Kit-positive, CD150-negative, CD41-negative, CD105-positive, and FcgR-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers found on mouse cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "c- Kit-positive erythroid progenitor cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:14:16Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002001",
      "lbl" : "CD34-positive, CD38-positive granulocyte monocyte progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granulocyte monocyte progenitor is CD34-positive, CD38-positive, IL-3receptor-alpha-positive and is CD45RA-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770" ]
        },
        "comments" : [ "Markers are for human cells. According to different research groups, CD45RA is present or absent on this cell population." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-13T03:19:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002002",
      "lbl" : "Kit-positive granulocyte monocyte progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granulocyte monocyte progenitor that is Kit-positive, CD34-positive, Fc-gamma receptor II/II-positive, and is Sca-1-negative, Il7ra-negative, Cxc3r1-negative, and CD90-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:16322423", "PMID:19022770", "PMID:19273628", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers are found on mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-13T03:19:28Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002003",
      "lbl" : "CD34-positive, GlyA-negative erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An erythroid progenitor cell that is CD34-positive and is GlyA-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ]
        },
        "comments" : [ "Cell markers associated with human cells." ],
        "xrefs" : [ {
          "val" : "FMA:83517"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:14:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002004",
      "lbl" : "CD34-negative, GlyA-negative proerythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A proerythoblast that is CD34-negative and GlyA-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19621348" ]
        },
        "comments" : [ "Cell surface markers are associated with human cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:31:50Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002005",
      "lbl" : "CD34-positive, CD38-positive megakaryocyte erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A megakaryocyte erythroid progenitor cell is CD34-positive, CD38-positive and is IL3-receptor alpha-negative and CD45RA-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:190227700" ]
        },
        "comments" : [ "Markers are associated with human cell type." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-13T03:43:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002006",
      "lbl" : "Kit-positive, CD34-negative megakaryocyte erythroid progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A megakaryocyte erythroid progenitor cell that is Kit-positive and is Sca1-negative, CD34-negative, CD90-negative, IL7r-alpha-negative and Fcgr II/III-low.",
          "xrefs" : [ "GOC:tfm", "PMID:12615892", "PMID:19022770", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-13T03:43:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002009",
      "lbl" : "macrophage dendritic cell progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages.",
          "xrefs" : [ "GOC:tfm", "PMID:19273628" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MDP"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-19T02:51:58Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002011",
      "lbl" : "Kit-positive macrophage dendritic cell progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell that can give rise to plasmacytoid and myeloid dendritic cells, and to monocytes and macrophages. Marker for this cell is Kit-high, CD115-positive, CD135-positive, Cx3cr1-positive, and is Il7ra-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:19273628" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "murine MDP"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-26T02:43:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002012",
      "lbl" : "Kit-low proerythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A proerythoblast that is Kit-low, Lyg76-positive, and CD71-positive.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:31:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002013",
      "lbl" : "GlyA-positive basophilic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basophilic erythroblast that is GlyA-positive.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ]
        },
        "comments" : [ "Markers are associated with human cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:41:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002014",
      "lbl" : "Kit-negative, Ly-76 high basophilic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basophilic erythroblast that is Lyg 76-high and is Kit-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ]
        },
        "comments" : [ "Cell surface markers are associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T10:41:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002015",
      "lbl" : "Kit-negative, Ly-76 high polychromatophilic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A polychromatophilic erythroblast that is Lyg 76-high and is Kit-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "late basophilic and polychromatophilic erythroblast"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-04-26T10:53:11Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002016",
      "lbl" : "CD71-low, GlyA-positive polychromatic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A polychromatiic erythroblast that is Gly-A-positive and CD71-low.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ]
        },
        "comments" : [ "Cell surface markers are associated with human cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-04-26T10:53:16Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002017",
      "lbl" : "Kit-negative, Ly-76 high orthochromatophilic erythroblasts",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An orthochromatophilic erythroblast that is ter119-high, CD71-low, and Kit-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ]
        },
        "comments" : [ "Cell surface markers associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T11:04:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002018",
      "lbl" : "CD71-negative, GlyA-positive orthochromatic erythroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An erythroblast that is GlyA-positive and CD71-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ]
        },
        "comments" : [ "Markers associated with human cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "val" : "2010-04-26T11:04:21Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002019",
      "lbl" : "Ly-76 high reticulocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A reticulocyte that is Ly76-high and is Kit-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:18539294" ]
        },
        "comments" : [ "Marker associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T11:37:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002020",
      "lbl" : "GlyA-positive reticulocytes",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A reticulocyte that is GlyA-positive.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:1638021" ]
        },
        "comments" : [ "Markers is associated with human cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T11:48:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002021",
      "lbl" : "GlyA-positive erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An enucleate erythrocyte that is GlyA-positive.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:20134094" ]
        },
        "comments" : [ "Marker is associated with human cell types." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-26T11:51:22Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002022",
      "lbl" : "Ly-76 high positive erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An enucleate erythrocyte that is Lyg-76-high.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:19805084" ]
        },
        "comments" : [ "Marker is associated with mouse cell types." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "val" : "2010-04-26T11:51:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002028",
      "lbl" : "basophil mast progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa",
          "xrefs" : [ "GOC:ak", "GOC:dsd", "GOC:tfm", "PMCID:PMC1312421" ]
        },
        "comments" : [ "There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "BMCP"
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        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-27T12:46:33Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002031",
      "lbl" : "hematopoietic lineage restricted progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic progenitor cell that is capable of developing into only one lineage of hematopoietic cells.",
          "xrefs" : [ "GOC:tfm", "PMID:19022770" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-06T03:43:20Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002032",
      "lbl" : "hematopoietic oligopotent progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic oligopotent progenitor cell that has the ability to differentiate into limited cell types but lacks lineage cell markers and self renewal capabilities.",
          "xrefs" : [ "GOC:tfm", "PMID:19022770", "https://orcid.org/0000-0001-5208-3432" ]
        },
        "comments" : [ "This cell type is intended to be compatible with any vertebrate hematopoietic oligopotent progenitor cell.  For mammalian hematopoietic oligopotent progenitor cells known to be lineage-negative, please use the term 'hematopoietic oligopotent progenitor cell' (CL_0001060)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-06T03:43:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002033",
      "lbl" : "short term hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell capable of rapid replenishment of myeloerythroid progenitors and limited self renewal capability. This cell is Kit-positive, Sca1-positive, CD34-positive, CD150-positive, and is Flt3-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:19022770" ]
        },
        "comments" : [ "Markers are associated with mouse cells. These cells are also reportedly CD11b-low and CD90-low." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ST stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ST-HSC"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-08T09:19:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002034",
      "lbl" : "long term hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell with long term self renewal capability. This cell is Kit-positive, Sca1-positive, CD150-positive, CD90-low, CD34-negative and Flt3-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:15572596", "PMID:17582345" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "LT stem cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "LT-HSC"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-08T09:19:28Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002035",
      "lbl" : "Slamf1-negative multipotent progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic progenitor that has restricted self-renewal capability. Cell is Kit-positive, Ly6-positive, CD150-negative and Flt3-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:19022770" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-08T11:16:33Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002036",
      "lbl" : "Slamf1-positive multipotent progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic progenitor that has some limited self-renewal capability. Cells are lin-negative, Kit-positive, CD34-positive, and Slamf1-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:19022770" ]
        },
        "comments" : [ "Markers are associated with mouse cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "KSL cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-08T11:16:35Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002038",
      "lbl" : "T follicular helper cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cell located in follicles of secondary lymph nodes that is BCL6-high, ICOS-high and PD1-high, and stimulates follicular B cells to undergo class-switching and antibody production.",
          "xrefs" : [ "GOC:tfm", "PMID:19855402", "PMID:20107805", "PMID:22043829" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T(FH)",
          "xrefs" : [ "PMID:20207847" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tfh",
          "xrefs" : [ "PMID:20107805", "PMID:20383172" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular B helper T cell",
          "xrefs" : [ "PMID:22043829" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular T cell",
          "xrefs" : [ "PMID:20107805", "PMID:21914188" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular T-cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular T-helper cell",
          "xrefs" : [ "PMID:22552227" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular helper T cell",
          "xrefs" : [ "PMID:22649468" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular helper T-cell",
          "xrefs" : [ "PMID:22508770" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-10-29T04:01:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002043",
      "lbl" : "CD34-positive, CD38-negative multipotent progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic multipotent progenitor cell that is CD34-positive, CD38-negative, CD45RA-negative, and CD90-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:18371405", "PMID:19022770" ]
        },
        "comments" : [ "Cell markers are associated with human hematopoietic multipotent progenitor cells." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-01-12T11:14:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002045",
      "lbl" : "fraction A pre-pro B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pro-B cell that is CD45R/B220-positive, CD43-positive, HSA-low, BP-1-negative and Ly6c-negative. This cell type is also described as being lin-negative, AA4-positive, Kit-positive, IL7Ra-positive and CD45R-positive.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:12633665", "PMID:17582343", "PMID:37442242", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers associated with mouse cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "fraction A"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pre pro B cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T10:50:07Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002046",
      "lbl" : "early pro-B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pro-B cell that is CD22-positive, CD34-positive, CD38-positive and TdT-positive (has TdT activity). Pre-BCR is expressed on the cell surface. Cell is CD19-negative, CD20-negative, complement receptor type 2-negative and CD10-low. D-to-J recombination of the heavy chain occurs at this stage.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:18432934" ]
        },
        "comments" : [ "Markers are commonly associated with human cells. These cells are also reportedly CD21-negative. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T11:19:11Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002047",
      "lbl" : "fraction B precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor B cell that is CD45RA-positive, CD43-positive, CD24-positive and BP-1-negative.",
          "xrefs" : [ "GOC:ak", "GOC:tfm", "PMID:18432934", "PMID:37442242" ]
        },
        "comments" : [ "Markers are commonly associated with mouse cells. These cells are also reportedly RAG1-positive and RAG2-positive." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Fr. B"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "Fraction B"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T11:56:21Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002048",
      "lbl" : "late pro-B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-B cell precursor is CD19-low, CD22-positive , CD34-positive, CD38-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:18432934" ]
        },
        "comments" : [ "Late pro-B cells are also reportedly CD10-positive, CD20-negative, CD21-negative, and TdT-positive. Transcription factors: PU.1-positive, Ikaros-positive, E2A-positive, and PAX5-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T12:06:06Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002049",
      "lbl" : "fraction C precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor B cell that is CD45R-positive, CD43-positive, CD24-positive, and BP-positive. Intracellularly expression of surrogate light chain, Rag1 and Rag2, TdT, occurs while there is no expression of mu heavy chain.",
          "xrefs" : [ "GOC:tfm", "PMID:17582343", "PMID:37442242" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "Fraction C"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T02:04:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002050",
      "lbl" : "fraction C' precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-BCR-positive precursor B cell that is CD24-high, CD25-positive, CD43-positive, CD45R-positive and BP-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:17582343", "PMID:37442242" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Fr. C'"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "Fraction C-prime"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T02:13:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002052",
      "lbl" : "fraction D precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pre-B cell that is pre-BCR-negative, and the kappa- and lambda- light immunoglobulin light chain-negative, CD43-low, and is BP-1-positive, CD45R-positive and CD25-positive. This cell type is also described as being AA4-positive, IgM-negative, CD19-positive, CD43-low/negative, and HSA-positive.",
          "xrefs" : [ "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934", "PMID:37442242", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Fraction D precursor B cells are also reportedly CD24-positive and sIgD-negative." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Fr. D"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fraction D pre-B cell",
          "xrefs" : [ "GOC:tfm" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T02:55:16Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002054",
      "lbl" : "fraction E immature B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature B cell that is IgM-positive, CD45R-positive, CD43-low, CD25-negative, and CD127-negative. This cell type has also been described as being AA4-positive, IgM-positive, CD19-positive, CD43-low/negative, and HSA-positive.",
          "xrefs" : [ "GOC:ak", "GOC:dsd", "GOC:tfm", "PMID:17582343", "PMID:18432934", "PMID:37442242" ]
        },
        "comments" : [ "Markers associated with mouse cells. These cells are also reportedly sIgD-negative." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-28T03:13:47Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002056",
      "lbl" : "fraction F mature B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature B cell subset originally defined as having being CD45R-positive, IgM-positive, IgD-positive and CD43-negative. Subsequent research demonstrated being CD21-positive and CD23-negative and CD93 negative.",
          "xrefs" : [ "GOC:tfm", "PMID:17582343", "PMID:37442242" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-30T03:01:48Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002059",
      "lbl" : "CD8-alpha-positive thymic conventional dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A conventional thymic dendritic cell that is CD8-alpha-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8alpha-alpha-positive thymic conventional dendritic cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DC.8+.Th"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-06-07T02:48:36Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002060",
      "lbl" : "melanophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanin-containing macrophage that obtains the pigment by phagocytosis of melanosomes.",
          "xrefs" : [ "GOC:tfm", "PMID:20479296", "PMID:2943821" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-06-22T10:46:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002062",
      "lbl" : "pulmonary alveolar type 1 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A squamous pulmonary alveolar epithelial cell that is flattened and branched. A pulmonary alveolar type 1 cell covers more than 98% of the alveolar surface. This large cell has thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange.",
          "xrefs" : [ "GOC:tfm", "PMID:20054144", "PMID:29463737", "http://www.copewithcytokines.de" ]
        },
        "comments" : [ "The marker set AGER can identify the Human cell type pulmonary alveolar type 1 cell in the lung with a confidence of 0.85 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung type 1 cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "membranous pneumocytes"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pulmonary alveolar type I cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "small alveolar cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "squamous alveolar cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "squamous alveolar lining cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 1 alveolar epithelial cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 1 pneumocyte",
          "xrefs" : [ "PMID:32491474" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type I alveolar cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type I alveolar epithelial cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type I pneumocyte"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000780"
        }, {
          "val" : "FMA:62500"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-06-23T04:37:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002063",
      "lbl" : "pulmonary alveolar type 2 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pulmonary alveolar epithelial cell that modulates the fluid surrounding the alveolar epithelium by secreting and recycling surfactants via specialized organelles called alveolar lamellar bodies. This cell type also contributes to tissue repair and can differentiate after injury into a pulmonary alveolar type 1 cell. This cuboidal cell is thicker than squamous alveolar cells, has a rounded apical surface that projects above the level of the surrounding epithelium, and its free surface is covered by short microvilli.",
          "xrefs" : [ "GOC:tfm", "ISBN:0412046911", "PMID:36138472", "PMID:8540632", "http://www.copewithcytokines.de" ]
        },
        "comments" : [ "The marker set SFTPA1 can identify the Human cell type pulmonary alveolar type 2 cell in the lung with a confidence of 0.95 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cuboidal type II cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "granular pneumocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "great alveolar cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lung type 2 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 alveolar epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 alveolocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 pneumocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type II alveolar cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type II alveolar epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type II alveolocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type II pneumocyte",
          "xrefs" : [ "PMID:32491474" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TII"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lung type II cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000538"
        }, {
          "val" : "FMA:62501"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-24T12:04:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002064",
      "lbl" : "pancreatic acinar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A secretory cell found in pancreatic acini that secretes digestive enzymes and mucins. This cell is a typical zymogenic cell, have a basal nucleus and basophilic cytoplasm consisting of regular arrays of granular endoplasmic reticulum with mitochondria and dense secretory granules.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:20395539", "http://www.copewithcytokines.de/cope.cgi?key=pancreatic%20acinar%20cells" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acinar cell of pancreas"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000028"
        }, {
          "val" : "CALOHA:TS-0737"
        }, {
          "val" : "FMA:63032"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-24T03:16:29Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002066",
      "lbl" : "Feyrter cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroendocrine cell found in the epithelium of the lungs and respiratory tract. This cell type is rounded or elliptical in shape, situated mainly in the basal part of the epithelium; regulates bronchial secretion, smooth muscle contraction, lobular growth, ciliary activity and chemoreception. Cell has an electron-lucent cytoplasm, contains numerous dense-cored vesicles with a clear halo between the core and the limiting membrane.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Kultschitzky cell of bronchiole"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "bronchiolar Kulchitsky cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "respiratory enterochromaffin cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:14118"
        } ],
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          "val" : "2010-06-28T08:24:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002067",
      "lbl" : "type A enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An enteroendocrine cell that produces glucagon.",
          "xrefs" : [ "GOC:tfm", "ISBN:0412046911" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:62939"
        } ],
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          "val" : "2010-09-10T10:48:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002068",
      "lbl" : "Purkinje myocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Specialized cardiac myocyte that is subendocardially interspersed with the regular cardiac muscle cell. They are uninucleate cylindrical cells, associated end-to-end in long rows, continue from the node to the atrioventricular bundle; relatively short compared to ordinary myocytes but are nearly twice their diameter.",
          "xrefs" : [ "FMA:0412046911", "GOC:tfm", "PMID:19939742" ]
        },
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Purkinje cell fiber"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Purkinje muscle cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myocytus conducens cardiacus"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001032"
        }, {
          "val" : "FMA:14146"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-28T08:36:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002069",
      "lbl" : "type II vestibular sensory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Mostly cylindrical, resemble Type 1 in their contents and the presence of a kinocilium and stereocilium apically; much greater variation in size, some almost span the entire thickness of the sensory epithelium, while others are smaller than Type 1; receive multiple efferent nerve boutons around their bases as well as afferent endings, which are small expansions rather than chalices.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "type 2 vestibular hair cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 vestibular sensory cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type II hair cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:67909"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-29T09:58:13Z"
        } ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002070",
      "lbl" : "type I vestibular sensory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Bottle-shaped with narrow neck; broad, rounded basal portion where nucleus is located; stereocilia and a single kinocilium is present apically; receive nerve bouton at their base from an afferent cup-shaped (chalice or calyx) nerve ending.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "type 1 vestibular hair cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 1 vestibular sensory cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type I hair cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62352"
        } ],
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          "val" : "2010-06-29T09:58:19Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002072",
      "lbl" : "nodal myocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized cardiac myocyte in the sinoatrial and atrioventricular nodes. The cell is slender and fusiform confined to the nodal center, circumferentially arranged around the nodal artery.",
          "xrefs" : [ "FMA:67101", "GOC:tfm" ]
        },
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        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "pacemaker cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "P cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardiac pacemaker cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myocytus nodalis"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004190"
        }, {
          "val" : "FMA:67101"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-29T11:41:37Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002073",
      "lbl" : "transitional myocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Specialized cardiac myocyte which is in the internodal tract and atrioventricular node. The cell is more slender than ordinary atrial myocytes and has more myofibrils than nodal myocytes.",
          "xrefs" : [ "FMA:67142", "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67142"
        } ],
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          "val" : "2010-06-29T02:39:32Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002074",
      "lbl" : "myocardial endocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The myoendocrine cellis a specialized myocyte localized mainly in the right and left atrial appendages, and also scattered within other areas of the atria and along the conductive system in the ventricular septum. The most conspicuous feature distinguishing myoendocrine cells from other atrial myoctyes is the presence of membane-bounded secretory granules (these granules contain precursor of cardiodilatins or atrial natriuretic polypeptides).",
          "xrefs" : [ "FMA:67111", "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67111"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-29T11:50:47Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002075",
      "lbl" : "brush cell of tracheobronchial tree",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rare type of columnar epithelial cell that is part of the tracheobronchial epithelium. This cell is characterized by a distinctive tuft of apical microvilli, which extends into the cytoplasm, and a pear-shaped morphology, broad at the base and tapering to a narrow apex. It plays vital roles in chemosensation, producing cytokines like IL-25, and enhancing mucociliary clearance through acetylcholine release to support mucus movement and airway defense.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:15817800", "PMID:30291131", "PMID:37925434" ]
        },
        "comments" : [ "The marker set POU2F3, HOMER3, MYB can identify the Human cell type brush cell of tracheobronchial tree in the lung with a confidence of 0.56 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "pulmonary brush cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-29T03:22:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002076",
      "lbl" : "endo-epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell derived from endoderm.",
          "xrefs" : [ "FMA:69075", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:69075"
        } ],
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          "val" : "2010-06-29T03:38:14Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002077",
      "lbl" : "ecto-epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell derived from ectoderm.",
          "xrefs" : [ "FMA:69074", "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:69074"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-06-29T03:38:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002078",
      "lbl" : "meso-epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Epithelial cell derived from mesoderm or mesenchyme.",
          "xrefs" : [ "FMA:69076", "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial mesenchymal cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69076"
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          "val" : "2010-06-29T03:49:14Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002079",
      "lbl" : "pancreatic ductal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Epithelial cell found in the ducts of the pancreas. This cell type contributes to the high luminal pH.",
          "xrefs" : [ "FMA:63099", "GOC:tfm", "PMID:14740223" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:63099"
        } ],
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          "val" : "2010-06-30T08:49:43Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002080",
      "lbl" : "pancreatic centro-acinar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cubodial epithelial cell that is continuous with the lining of intercalated ducts that drain the acinus. This cell type secretes a high pH solution to aid in activation of zymogens, and can differentiate into endocrine and exocrine pancreatic cell types.",
          "xrefs" : [ "GOC:tfm", "PMID:12142741", "PMID:20018761", "PMID:8185160" ]
        },
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          "val" : "centroacinar cell of Langerhans"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic centroacinar cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62455"
        } ],
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          "val" : "2010-06-30T08:49:52Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002081",
      "lbl" : "type II cell of carotid body",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "This cell resembles a glia cell, express the glial marker S100 and act as a supporting cell to type I cell. This cell is located in a small cluster of type I and type II cells near the fork of the carotid artery.",
          "xrefs" : [ "GOC:tfm", "PMID:7938227", "http://en.wikipedia.org/wiki/Carotid_body" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "sheath cell of carotid body"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84187"
        } ],
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          "val" : "2010-06-30T04:23:42Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002082",
      "lbl" : "type II cell of adrenal medulla",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell of the adrenal medulla that produces epinephrine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adrenal secreting cell of the adrenal medulla"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adrenergic chromaffin cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epiniphrine secreting cell of the adrenal medulla"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69322"
        } ],
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          "val" : "2010-07-14T09:41:42Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002083",
      "lbl" : "type I cell of adrenal medulla",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell of the adrenal medulla that produces norepinephrine.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "noradrenergic chromaffin cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69321"
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        "basicPropertyValues" : [ {
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          "val" : "2010-07-14T10:12:24Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002084",
      "lbl" : "Boettcher cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Boettcher cell is a polyhedral cells on the basilar membrane of the cochlea, and is located beneath Claudius cells. A Boettcher cell is considered a supporting cell for the organ of Corti, and is present only in the lower turn of the cochlea. These cells interweave with each other, and project microvilli into the intercellular space. Because of their structural specialization, a Boettcher cell is believed to play a significant role in the function of the cochlea. They demonstrate high levels of calmodulin, and may be involved in mediating Ca(2+) regulation and ion transport.",
          "xrefs" : [ "GOC:tfm", "http://en.wikipedia.org/wiki/Boettcher_cell" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Boettcher's cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bottcher cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Bottcher's cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-07-14T03:22:02Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002086",
      "lbl" : "specialized cardiac myocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cardiac myocyte that is an excitable cells in the myocardium, specifically in the conducting system of heart.",
          "xrefs" : [ "FMA:67968", "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67968"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-07-21T01:33:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002087",
      "lbl" : "nongranular leukocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A leukocyte that lacks granules.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "agranular leukocyte"
        } ],
        "xrefs" : [ {
          "val" : "FMA:62855"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-07-22T11:30:33Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002088",
      "lbl" : "interstitial cell of Cajal",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "This is a cell found in the gastrointestinal tract of mammals and serves as a pacemaker that triggers gut contraction. ICCs mediate inputs from the enteric nervous system to smooth muscle cells and are thought to be the cells from which gastrointestinal stromal tumors (GISTs) arise.",
          "xrefs" : [ "GOC:tfm", "PMID:16460275", "PMID:19520112" ]
        },
        "comments" : [ "Some argue this cell type is of mesenchymal origin." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ICC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intestinal pacemaker cell",
          "xrefs" : [ "GOC:pr" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003914"
        }, {
          "val" : "FMA:86573"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-07-22T03:26:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002090",
      "lbl" : "polar body",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "One of two small cells formed by the first and second meiotic division of oocytes.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X", "http://en.wikipedia.org/wiki/Polar_body" ]
        },
        "xrefs" : [ {
          "val" : "EHDAA2:0004716"
        }, {
          "val" : "FMA:85543"
        }, {
          "val" : "MESH:D059705"
        }, {
          "val" : "WBbt:0008429"
        }, {
          "val" : "XAO:0000262"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T09:49:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002091",
      "lbl" : "primary polar body",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small cell formed by the first meiotic division of oocytes.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "first polar body",
          "xrefs" : [ "EHDAA2:0000541" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polocytus primarius",
          "xrefs" : [ "FMA:18650" ]
        } ],
        "xrefs" : [ {
          "val" : "EHDAA2:0000541"
        }, {
          "val" : "EMAPA:16032"
        }, {
          "val" : "FMA:18650"
        }, {
          "val" : "VHOG:0000464"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T09:49:58Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002092",
      "lbl" : "bone marrow cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found in the bone marrow. This can include fibroblasts, macrophages, adipocytes, osteoblasts, osteoclasts, endothelial cells and hematopoietic cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256" ]
        },
        "comments" : [ "MH consider whether bone marrow cells are bone cells in the structural sense vs. being part of bone organ sense." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0004850"
        }, {
          "val" : "FMA:83621"
        }, {
          "val" : "MESH:D001854"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-07-22T04:48:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002093",
      "lbl" : "secondary polar body",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small cell formed by the second meiotic division of oocytes. In mammals, the second polar body may fail to form unless the ovum has been penetrated by a sperm cell.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "polocytus secundarius",
          "xrefs" : [ "FMA:18651" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "second polar body",
          "xrefs" : [ "EHDAA2:0001820" ]
        } ],
        "xrefs" : [ {
          "val" : "EHDAA2:0001820"
        }, {
          "val" : "EMAPA:16034"
        }, {
          "val" : "EMAPA:16045"
        }, {
          "val" : "FMA:18651"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T09:50:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002095",
      "lbl" : "hilus cell of ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell in the hilum of the ovary that produces androgens.",
          "xrefs" : [ "GOC:tfm", "ISBN:068340007X" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hilar cell of ovary"
        } ],
        "xrefs" : [ {
          "val" : "FMA:18710"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T11:18:18Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002097",
      "lbl" : "cortical cell of adrenal gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the adrenal cortex. Cell types include those that synthesize and secrete chemical derivatives (steroids) of cholesterol.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adrenal cortex cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adrenocortical cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69545"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T01:37:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002099",
      "lbl" : "type I cell of adrenal cortex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small, polyhedral, cell found in rounded groups or curved columns with deeply staining nuclei, scanty basophilic cytoplasm and a few lipid droplets. This cell in the zona glomerulosa produces mineralocorticoids.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of zona glomerulosa of adrenal gland"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69273"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T01:42:02Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002101",
      "lbl" : "CD38-positive naive B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-positive naive B cell is a mature B cell that has the phenotype CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ naive B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ naive B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive naive B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002102",
      "lbl" : "CD38-negative naive B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-negative naive B cell is a mature B cell that has the phenotype CD38-negative, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD38- naive B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- naive B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative naive B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002103",
      "lbl" : "IgG-positive double negative memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgG-positive double negative memory B cell is a double negative memory B cell with the phenotype IgG-positive, IgD-negative, and CD27-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ dn memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ dn memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ dn memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ dn memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ double negative memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ double negative memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ double negative memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG+ double negative memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive dn memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive dn memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive dn memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive dn memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive double negative memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive double negative memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-positive double negative memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002104",
      "lbl" : "IgG-negative double negative memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgG-negative double negative memory B cell is a double negative memory B cell with the phenotype IgG-negative, IgD-negative, and CD27-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgG- dn memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- dn memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- dn memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- dn memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- double negative memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- double negative memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- double negative memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- double negative memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative dn memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative dn memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative dn memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative dn memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative double negative memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative double negative memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative double negative memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002105",
      "lbl" : "CD38-positive IgG memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-positive IgG memory B cell is a class switched memory B cell that expresses IgG on the cell surface with the phenotype CD38-positive and IgG-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ IgG memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ IgG memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ IgG memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ IgG memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive IgG memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive IgG memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive IgG memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002106",
      "lbl" : "IgD-positive CD38-positive IgG memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgD-positive CD38-positive IgG memory B cell is a CD38-positive IgG-positive class switched memory B cell that has class switched and expresses IgD on the cell surface with the phenotype IgD-positive, CD38-positive, and IgG-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002107",
      "lbl" : "IgD-negative CD38-positive IgG memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An IgD-negative CD38-positive IgG memory B cell is a CD38-positive IgG-positive that has class switched and lacks expression of IgD on the cell surface with the phenotype IgD-negative, CD38-positive, and IgG-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002108",
      "lbl" : "CD38-negative IgG memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-negative IgG memory B cell is a IgG-positive class switched memory B cell that has class switched and expresses IgG on the cell surface with the phenotype CD38-negative, IgD-negative, and IgG-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002109",
      "lbl" : "B220-positive CD38-positive naive B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-positive CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-positive, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, and that has not yet been activated by antigen in the periphery.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B220+CD38+ naive B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220+CD38+ naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220+CD38+ naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220+CD38+ naive B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220-positive CD38-positive naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220-positive CD38-positive naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B220-positive CD38-positive naive B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+B220+ naive B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+B220+ naive B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+B220+ naive B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+B220+ naive B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002110",
      "lbl" : "B220-low CD38-positive naive B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-low CD38-positive naive B cell is a CD38-positive naive B cell that has the phenotype B220-low, CD38-positive, surface IgD-positive, surface IgM-positive, and CD27-negative, that has not yet been activated by antigen in the periphery.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002111",
      "lbl" : "CD38-negative unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An CD38-negative unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-negative, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD38- unswitched memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- unswitched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- unswitched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38- unswitched memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative unswitched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative unswitched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-negative unswitched memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002112",
      "lbl" : "B220-positive CD38-negative unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-positive CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-positive, CD38-negative, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002113",
      "lbl" : "B220-low CD38-negative unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-low CD38-negative unswitched memory B cell is a CD38-negative unswitched memory B cell that has the phenotype B220-low, CD38-negative, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002114",
      "lbl" : "CD38-positive unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-positive unswitched memory B cell is an unswitched memory B cell that has the phenotype CD38-positive, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ unswitched memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ unswitched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ unswitched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38+ unswitched memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive unswitched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive unswitched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "CD38-positive unswitched memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002115",
      "lbl" : "B220-positive CD38-positive unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-positive CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-positive, CD38-positive, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002116",
      "lbl" : "B220-low CD38-positive unswitched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-low CD38-positive unswitched memory B cell is a CD38-positive unswitched memory B cell that has the phenotype B220-low, CD38-positive, IgD-positive, CD138-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002117",
      "lbl" : "IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A class switched memory B cell that lacks IgG on the cell surface.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IgG- class switched memory B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- class switched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- class switched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG- class switched memory B-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative class switched memory B lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative class switched memory B-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "IgG-negative class switched memory B-lymphocyte"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002118",
      "lbl" : "CD38-negative IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-negative IgG-negative memory B cell is a IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-negative and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002119",
      "lbl" : "CD38-positive IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD38-positive IgG-negative memory B cell is an IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD38-positive and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002120",
      "lbl" : "CD24-positive CD38-negative IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An CD24-positive CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-positive, CD38-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002121",
      "lbl" : "CD24-negative CD38-negative IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD24-negative CD38-negative IgG-negative memory B cell is a CD38-negative IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype CD24-negative, CD38-negative, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002122",
      "lbl" : "B220-positive CD38-positive IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-positive CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-positive, CD38-positive, and IgG-negative.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002123",
      "lbl" : "B220-low CD38-positive IgG-negative class switched memory B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B220-low CD38-positive IgG-negative memory B cell is a CD38-positive IgG-negative class switched memory B cell that lacks IgG on the cell surface with the phenotype B220-low, CD38-positive, and IgG-positive.",
          "xrefs" : [ "GOC:dsd", "GOC:rhs", "GOC:tfm", "PMID:20123131" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002128",
      "lbl" : "Tc17 cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, alpha-beta T cell that has the phenotype CXCR3-negative, CCR6-positive, CCR5-high, CD45RA-negative, and capable of producing IL-17 and some IFNg.",
          "xrefs" : [ "GOC:add", "GOC:dsd", "GOC:tfm", "PMID:19201830", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'Tc17 CD8+ T cell', but its logical definition includes additional known characteristics of Tc17 T cells.  Found in the CD27-positive, CD28-positive or CD27-negative, CD28-positive fractions with the phenotype CCR4-negative and CCR7-negative (this sentence not part of definition)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD8-positive Th17 cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tc17 CD8+ T cell",
          "xrefs" : [ "PMID:22343568" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tc17 T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tc17 T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tc17 T-cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Tc17 T-lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 CD8-positive T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Th17 non-TFH CD8-positive T cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002132",
      "lbl" : "stromal cell of ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stomal cell of the ovary",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ovarian stromal cell",
          "xrefs" : [ "GOC:cjm" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:72299"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T12:10:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002134",
      "lbl" : "stromal cell of ovarian medulla",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell of the ovarian medulla.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:256171"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-23T12:12:17Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002136",
      "lbl" : "type II cell of adrenal cortex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell in the zona fasciculata that produce glucocorticoids, e.g cortisol.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "type II cortical cell of adrenal gland"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69547"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T01:50:42Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002137",
      "lbl" : "type III cell of adrenal cortex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell in the zona reticularis that produce sex hormones.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "xrefs" : [ {
          "val" : "FMA:69564"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T01:50:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002138",
      "lbl" : "endothelial cell of lymphatic vessel",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A endothelial cell of a lymphatic vessel. The border of the oak leaf-shaped endothelial cell of initial lymphatics are joined by specialized buttons. The discontinuous feature of buttons distinguishes them from zippers in collecting lymphatics, but both types of junctions are composed of proteins typical of adherens junctions and tight junctions found in the endothelium of blood vessels. Buttons seal the sides of flaps of the oak leaf-shaped endothelial cell, leaving open the tips of flaps as routes for fluid entry without disassembly and reformation of intercellular junctions.",
          "xrefs" : [ "GOC:tfm", "PMID:17846148" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "LEC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lymphatic endothelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004167"
        }, {
          "val" : "FMA:68458"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T02:05:28Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002139",
      "lbl" : "endothelial cell of vascular tree",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.",
          "xrefs" : [ "GOC:dsd", "GOC:tfm", "PMID:12768659" ]
        },
        "comments" : [ "These cells are reportedly CD31-positive, CD34-positive, CD144-positive, TAL1-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "vascular endothelial cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "cubodial endothelial cell of vascular tree"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001854"
        }, {
          "val" : "CALOHA:TS-1106"
        }, {
          "val" : "FMA:67755"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T02:06:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002140",
      "lbl" : "skin sebocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An acinar cell that is part of a skin sebaceous gland. This cell produces and secretes sebum into hair follicles.",
          "xrefs" : [ "GOC:tfm", "PMID:37205445" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "acinar cell of sebaceous gland"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acinar cell of skin sebaceous gland"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004613"
        }, {
          "val" : "FMA:70953"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T09:27:52Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002144",
      "lbl" : "capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell found in capillaries.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0004956"
        }, {
          "val" : "CALOHA:TS-0112"
        }, {
          "val" : "FMA:67756"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T10:15:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002145",
      "lbl" : "multiciliated columnar cell of tracheobronchial tree",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multi-ciliated epithelial cell located in the trachea and bronchi, characterized by a columnar shape and motile cilia on its apical surface. These cilia facilitate mucociliary clearance by moving mucus and trapped particles toward the pharynx.",
          "xrefs" : [ "GOC:tfm", "PMID:28400610" ]
        },
        "comments" : [ "The marker set C1orf194, MS4A8 can identify the Human cell type multiciliated columnar cell of tracheobronchial tree in the lung with a confidence of 0.86 (NS-Forest FBeta value).", "These cells possess numerous cilia on their surface, typically ranging from 200 to 300 per cell. The cilia vary in length, measuring between 6 to 7 μm in the upper airways (trachea) and becoming shorter, around 4 μm, in the smaller airways (terminal bronchioles). These cells form a two-layered 'coat' in the airway: the lower 'sol' layer is watery, allowing the cilia to beat in coordinated waves, while the upper 'gel' layer is thick and sticky, trapping inhaled particles." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ciliated columnar cell of tracheobronchial tree"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70542"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T03:38:29Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002148",
      "lbl" : "dental pulp cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell found within the dental pulp.",
          "xrefs" : [ "GOC:tfm", "PMID:36267574" ]
        },
        "xrefs" : [ {
          "val" : "CALOHA:TS-0195"
        }, {
          "val" : "FMA:87170"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T02:52:09Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002149",
      "lbl" : "epithelial cell of uterus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the uterus. This cell has a mesodermal origin.",
          "xrefs" : [ "GOC:tfm", "PMID:11331626", "PMID:16960017", "PMID:21698266" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:256161"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-08-24T10:45:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002152",
      "lbl" : "columnar cell of endocervix",
      "type" : "CLASS",
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          "val" : "A simple columnar epithelial cell located in the endocervix.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0002153",
      "lbl" : "corneocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The dead keratin-filled squamous cell of the stratum corneum. This cell type lacks a nucleus.",
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          "val" : "2010-08-24T10:53:03Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002159",
      "lbl" : "general ecto-epithelial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Epithelial cells derived from general body ectoderm and ectoderm placodes.",
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        "xrefs" : [ {
          "val" : "FMA:70556"
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          "val" : "2010-08-26T08:31:08Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002165",
      "lbl" : "phalangeal cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A supporting cell that is attached to the basement membrane and forms rows that support the hair cells.",
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        "xrefs" : [ {
          "val" : "FMA:79800"
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          "val" : "2010-08-25T01:29:07Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002166",
      "lbl" : "epithelial cell of Malassez",
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      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that remains from the disintegration of the epithelial root sheath involved in the development of teeth.",
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        },
        "synonyms" : [ {
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          "val" : "epithelial cell rests of Malassez"
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          "val" : "epithelial debris of Malassez"
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          "val" : "FMA:62987"
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          "val" : "2010-08-26T08:51:27Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002167",
      "lbl" : "olfactory epithelial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A specialized cell involved in sensory perception of smell.",
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        "xrefs" : [ {
          "val" : "FMA:67870"
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          "val" : "2010-08-26T01:47:13Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002169",
      "lbl" : "basal cell of olfactory epithelium",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell located on the basal lamina of the olfactory epithelium.",
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        "xrefs" : [ {
          "val" : "FMA:62303"
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          "val" : "2010-08-26T01:58:54Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002170",
      "lbl" : "keratinized cell of the oral mucosa",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A keratinized cell located in the hard palate or gingiva.",
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        "basicPropertyValues" : [ {
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          "val" : "2010-08-26T02:51:30Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002171",
      "lbl" : "globose cell of olfactory epithelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rounded or elliptical epithelial cell, with pale-staining open face nucleus and pale cytoplasm rich in free ribosomes and clusters of centrioles; form a distinct basal zone spaced slightly from the basal surface of the epithelium.",
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        "synonyms" : [ {
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          "val" : "blastema cell of olfactory epithelium"
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          "val" : "FMA:67874"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002172",
      "lbl" : "interdental cell of cochlea",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A long, spindle-shaped supporting cells arranged in parallel rows that secretes components of the tectorial membrane and potassium ions into the endolymph.",
          "xrefs" : [ "GOC:tfm", "MP:0004482", "PMID:2111803" ]
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        "synonyms" : [ {
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          "val" : "interdental cell"
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          "val" : "FMA:79797"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002173",
      "lbl" : "extraglomerular mesangial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A cell that is a specialized type of pericyte providing structural support for the capillary loops of kidney. A flat, elongated cell with extensive fine cytoplasmic processes found outside the kidney glomerulus near the macula densa and bound laterally by afferent and efferent arterioles. Being phagocytic, this cell participates in the continuous turnover of the basal lamina by removing its outer portion containing residues of filtration, while the lamina is renewed on its inner surface by the endothelial cells.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Goormaghtigh cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polar cushion cells"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lacis cell"
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        "xrefs" : [ {
          "val" : "FMA:84143"
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          "val" : "KUPO:0001033"
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          "val" : "2010-08-25T02:20:55Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002174",
      "lbl" : "follicular cell of ovary",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A cell within the follicle of an ovary.",
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        "xrefs" : [ {
          "val" : "EMAPA:31247"
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          "val" : "FMA:70589"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002177",
      "lbl" : "folliculostellate cell of pars distalis of adenohypophysis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supporting cell of the anterior pituitary gland involved in trophic and catabolic processes; expresses a broad spectrum of cytokeratins indicative of their epithelial nature.",
          "xrefs" : [ "GOC:tfm" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "folliculostellate cell of pars anterior of adenohypophysis"
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        "xrefs" : [ {
          "val" : "FMA:83102"
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          "val" : "2010-08-25T03:10:10Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002178",
      "lbl" : "epithelial cell of stomach",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell found in the lining of the stomach.",
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          "val" : "2010-08-25T03:22:08Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002179",
      "lbl" : "foveolar cell of stomach",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A simple columnar cell that populates the entire luminal surface including the gastric pits. This cell types secrete mucus to form a thick protective, lubricant layer over the gastric wall.",
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          "val" : "surface mucosal cell of stomach"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002180",
      "lbl" : "mucous cell of stomach",
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        "definition" : {
          "val" : "An epithelial cell of the stomach. This cell produces mucous.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0002181",
      "lbl" : "mucous neck cell of gastric gland",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A columnar epithelial mucous secreting cell located in the neck of the gastric glands. These cells have numerous apical secretory vesicles containing mucins and a basally displaced nucleus. The mucous they secrete is distinct histochemically from that of the surface mucous cells of stomach.",
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          "val" : "https://orcid.org/0009-0005-7919-4905"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002183",
      "lbl" : "stem cell of gastric gland",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A stomach epithelial cell that is olumnar in form with a few short apical microvilli; relatively undifferentiated mitotic cell from which other types of gland are derived; few in number, situated in the isthmus region of the gland and base of the gastric pit.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0002184",
      "lbl" : "basal proper cell of olfactory epithelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A flat or angular epithelial cell with condensed nuclei and darkly staining cytoplasm containing numerous intermediate filaments inserted into desmosomes contacting surrounding supporting cells; lie in contact with the basal lamina of olfactory epithelium.",
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          "val" : "FMA:62304"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002187",
      "lbl" : "basal cell of epidermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mitotically active, columnar-shaped keratinocyte located in the stratum basale of the epidermis and attached to the basement membrane. This cell exhibits heterogeneity, encompassing stem and progenitor subpopulations with distinct molecular and proliferative characteristics (Haensel et al., 2020), and serves as the primary source of new keratinocytes for epidermal renewal, homeostasis, and regeneration.",
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          "val" : "epidermal basal cell",
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          "pred" : "hasExactSynonym",
          "val" : "epidermal basal keratinocyte",
          "xrefs" : [ "PMID:7058342" ]
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        "xrefs" : [ {
          "val" : "FMA:70571"
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      "lbl" : "glomerular endothelial cell",
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        "definition" : {
          "val" : "An endothelial cell that is part of the glomerulus of the kidney. This cell is flattened, highly fenestrated, and plays a vital role in the formation of glomerular ultrafiltrate.",
          "xrefs" : [ "GOC:tfm", "PMID:15840009" ]
        },
        "comments" : [ "Glomerular endothelial cells have 60-80 nm fenestrations typically lacking diaphragms in adults but present during embryonic development. Some studies found diaphragms in 2-6% of mature rat glomerular capillaries. Their presence may depend on fixation techniques, developmental stage, or dynamic cell changes. Additionally, these cells help maintain the structural integrity of glomerular capillaries through interactions with the basement membrane and podocytes." ],
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      "id" : "http://purl.obolibrary.org/obo/CL_0002191",
      "lbl" : "granulocytopoietic cell",
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        "definition" : {
          "val" : "A cell involved in the formation of a granulocyte.",
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      "lbl" : "monopoietic cell",
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        "definition" : {
          "val" : "A cell involved in the formation of a monocyte (monopoiesis).",
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        "xrefs" : [ {
          "val" : "FMA:83552"
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      "lbl" : "hepatic stem cell",
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          "val" : "A stem cell that can give rise to the cells of the liver. The term usually refers to the self-renewing pool of hepatocyte precursors in the adult liver (differently from 'hepatoblast', often used for fetal precursors of hepatocytes).",
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          "val" : "2010-08-30T02:00:42Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002196",
      "lbl" : "hepatic oval stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transient hepatic stem cell observed after liver injury with a high nuclear to cytoplasm ratio that can differentiate into mature hepatocytes and bile duct cells. Arises from more than one tissue.",
          "xrefs" : [ "PMID:17901986" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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          "pred" : "hasExactSynonym",
          "val" : "hepatic oval cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hepatic progenitor cell",
          "xrefs" : [ "https://doi.org/10.1038/s12276-020-0483-0" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver progenitor cell",
          "xrefs" : [ "https://doi.org/10.1038/s12276-020-0483-0" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004270"
        }, {
          "val" : "FMA:86576"
        } ],
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          "val" : "2010-08-30T02:01:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002198",
      "lbl" : "oncocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A large epithelial cell with an extremely acidophilic and granular cytoplasm, containing vast numbers of mitochondria; such cells may undergo neoplastic transformation. From the Greek word onkos meaning swelling, this cell type is found in parathyroid, salivary and thyroid glands.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "oxyphil"
        } ],
        "xrefs" : [ {
          "val" : "FMA:67606"
        }, {
          "val" : "MESH:D024862"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T11:26:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002199",
      "lbl" : "oxyphil cell of parathyroid gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An oncocyte located in the parathyroid gland.",
          "xrefs" : [ "PMID:20013317" ]
        },
        "xrefs" : [ {
          "val" : "FMA:69084"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T11:33:23Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002200",
      "lbl" : "oxyphil cell of thyroid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An oncocyte located in the thyroid.",
          "xrefs" : [ "GOC:tfm", "PMID:20013317" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Askanazy cells"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Hurthle cells"
        } ],
        "xrefs" : [ {
          "val" : "FMA:87169"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T11:33:26Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002202",
      "lbl" : "epithelial cell of tracheobronchial tree",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the tracheobronchial tree.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:66816"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T02:09:14Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002203",
      "lbl" : "tuft cell of large intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of large intestine.",
          "xrefs" : [ "GOC:tfm", "PMID:35271673" ]
        },
        "comments" : [ "Brush cells are a distinct cell type from brush border cell-types." ],
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "brush cell of epithelium proper of large intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brush cell of large intestine",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tuft cell of epithelium of large intestine",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:263222"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T02:20:50Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002204",
      "lbl" : "tuft cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell found in various organs, including the gastrointestinal and respiratory tracts, characterized by a tuft of 120-140 blunt microvilli on its apical surface. This cell exhibits diverse functions depending on its location, which includes chemosensation, initiation of immune responses, contribution to mucociliary clearance, and defense against parasites.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651", "PMID:15817800", "PMID:30379593", "PMID:36704202" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
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          "val" : "brush cell",
          "xrefs" : [ "PMID:36704202" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "caveolated cell",
          "xrefs" : [ "PMID:36704202" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fibrillovesicular cell",
          "xrefs" : [ "PMID:36704202" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multivesicular cell",
          "xrefs" : [ "PMID:32307399" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "peculiar cell",
          "xrefs" : [ "PMID:36704202" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:67978"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T02:28:53Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002206",
      "lbl" : "brush cell of terminal bronchiole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A brush cell of the epithelium in the terminal bronchiole.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263228"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T02:38:36Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002207",
      "lbl" : "brush cell of trachea",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Brush cell of the epithelium in the trachea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263224"
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          "val" : "2010-09-02T02:38:37Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002208",
      "lbl" : "brush cell of bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A brush cell found in the epithelium of bronchus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263226"
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        "basicPropertyValues" : [ {
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0002209",
      "lbl" : "intermediate epitheliocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell present in the trachea and bronchi; columnar in shape; generally lack cilia; immature forms of ciliated or secretory cells which have been formed from stem cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:0517223651" ]
        },
        "synonyms" : [ {
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          "val" : "undifferentiated columnar cell of tracheobronchial tree"
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        "xrefs" : [ {
          "val" : "FMA:69060"
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          "val" : "2010-09-02T02:53:59Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002218",
      "lbl" : "immature dendritic epithelial T cell precursor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double negative thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-positive. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org" ]
        },
        "comments" : [ "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ],
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          "pred" : "hasExactSynonym",
          "val" : "immature DEC precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature DETC precursor"
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        "basicPropertyValues" : [ {
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          "val" : "2010-10-07T01:58:00Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002220",
      "lbl" : "interstitial cell of pineal gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell located between the pinealocytes.",
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        },
        "xrefs" : [ {
          "val" : "FMA:86575"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-02T04:28:41Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002222",
      "lbl" : "vertebrate lens cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell comprising the transparent, biconvex body separating the posterior chamber and vitreous body, and constituting part of the refracting mechanism of the mammalian eye.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "xrefs" : [ {
          "val" : "FMA:70950"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002224",
      "lbl" : "lens epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the cuboidal epithelium that covers the lens. The cells of the lens epithelium regulate most of the homeostatic functions of the lens. As ions, nutrients, and liquid enter the lens from the aqueous humor, Na+/K+ ATPase pumps in the lens epithelial cells pump ions out of the lens to maintain appropriate lens osmolarity and volume, with equatorially positioned lens epithelium cells contributing most to this current. The activity of the Na+/K+ ATPases keeps water and current flowing through the lens from the poles and exiting through the equatorial regions. The cells of the lens epithelium also serve as the progenitors for new lens fibers. It constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.",
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        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:67559"
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          "val" : "2010-09-07T10:45:47Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002231",
      "lbl" : "epithelial cell of prostate",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the prostate.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "prostate epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:256163"
        }, {
          "val" : "FMA:66817"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-07T01:49:29Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002232",
      "lbl" : "epithelial cell of prostatic duct",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of prostatic duct.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ductal epithelial cell of prostate",
          "xrefs" : [ "FMA:74224" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:74224"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-07T01:55:51Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002236",
      "lbl" : "basal epithelial cell of prostatic duct",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that constitutes the basal layer of epithelium in the prostatic duct.",
          "xrefs" : [ "GOC:tfm", "PMID:15226377" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:74226"
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          "val" : "2010-09-07T01:59:12Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002240",
      "lbl" : "marrow fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast in the bone marrow.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:84377"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-07T02:25:18Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002241",
      "lbl" : "pulmonary interstitial fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblasts found in interstitial spaces in the pulmonary tract. Greater numbers of these cells are found in idiopathic pulmonary fibrosis.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "The marker set DPT, APOD can identify the Human cell type pulmonary interstitial fibroblast in the lung with a confidence of 0.58 (NS-Forest FBeta value)." ],
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pulmonary myofibroblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pulmonary septal cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:84467"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-07T02:29:38Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002242",
      "lbl" : "nucleate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell containing at least one nucleus.",
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        },
        "xrefs" : [ {
          "val" : "FMA:67513"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-07T03:32:33Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002243",
      "lbl" : "smooth muscle cell of sphincter of pupil",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A circular smooth muscle cell of the iris, innervated by the ciliary nerves (parasympathetic), and acting to contract the pupil. This muscle cell derives from neuroectoderm. This smooth muscle cell results from transformation of epithelial cells to smooth muscle cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544", "ISBN:0721694128" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "smooth muscle fiber of sphincter of pupil"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "smooth muscle fibre of sphincter of pupil"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70611"
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          "val" : "2010-09-08T08:53:42Z"
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      "lbl" : "squamous cell of ectocervix",
      "type" : "CLASS",
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          "val" : "A stratified squamous epithelial cell located in the ectocervix.",
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          "val" : "2010-09-08T09:12:23Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002246",
      "lbl" : "peripheral blood stem cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A hematopoeitic stem cell found in the blood. Normally found in very limited numbers in the peripheral circulation (less than 0.1% of all nucleated cells).",
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        "synonyms" : [ {
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          "val" : "PBSC"
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          "val" : "FMA:86711"
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          "val" : "MESH:D000072916"
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          "val" : "2010-09-07T03:57:09Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002250",
      "lbl" : "intestinal crypt stem cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A stem cell located in epithelium the based of the crypt of Lieberkuhn. Division of these cells serve both to maintain the stem cell population and produce the transit amplifying cells that are all precursors of all cell types that populate the intestinal epithelium.",
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          "val" : "stem cell of intestinal crypt of Lieberkuhn"
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          "val" : "FMA:63379"
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          "val" : "2010-09-08T09:21:22Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002251",
      "lbl" : "epithelial cell of alimentary canal",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the musculomembranous digestive tube extending from the mouth to the anus.",
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-08T09:26:53Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002252",
      "lbl" : "epithelial cell of esophagus",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell of the lining of the esophagus.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "FMA:63071"
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          "val" : "2010-09-08T09:28:20Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002253",
      "lbl" : "epithelial cell of large intestine",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell of the lining of the large intestine.",
          "xrefs" : [ "GOC:tfm" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "epithelial cell of colon"
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          "val" : "BTO:0004297"
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          "val" : "FMA:256157"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-08T09:28:22Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002254",
      "lbl" : "epithelial cell of small intestine",
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        "definition" : {
          "val" : "An epithelial cell of the lining of the small intestine.",
          "xrefs" : [ "GOC:tfm" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:256159"
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          "val" : "2010-09-08T09:41:46Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002255",
      "lbl" : "stromal cell of endometrium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell of the endometrium, characterized by its fibroblast-like morphology, regenerative capacity, and ability to undergo decidualization. It differentiates into a decidual stromal cell during pregnancy, essential for embryo implantation and maintenance. This cell is involved in tissue proliferation, remodeling, and breakdown, responding to hormonal changes, particularly estrogen and progesterone.",
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          "val" : "stromal cell of uterus"
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          "pred" : "hasExactSynonym",
          "val" : "endometrial stromal cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "endometrial stromal fibroblast",
          "xrefs" : [ "PMID:30309298" ]
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          "val" : "CALOHA:TS-1266"
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          "val" : "FMA:86490"
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          "val" : "2010-09-08T09:50:04Z"
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      "lbl" : "supporting cell of carotid body",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A supportive cell that has characteristics of glial cell. Processes of this cell envelope the junctions between glomus cells and nerve endings.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0002257",
      "lbl" : "epithelial cell of thyroid gland",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell of thyroid gland.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "An epithelial cell that is part of the thyroid follicle epithelium, with a shape that ranges from squamous when inactive to cuboidal or columnar when active, reflecting its hormonal activity. Its apical surface is lined with microvilli projecting into the colloid-filled lumen, where it synthesizes, stores, and secretes the thyroid hormones thyroxine (T4) and triiodothyronine (T3), releasing them into the bloodstream in response to thyroid-stimulating hormone (TSH).",
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          "val" : "principal cell of thyroid gland"
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          "val" : "thyroid gland follicular cell"
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      "lbl" : "epithelial cell of parathyroid gland",
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        "definition" : {
          "val" : "An epithelial cell of the parathyroid gland.",
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      "lbl" : "endothelial cell of viscerocranial mucosa",
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        "definition" : {
          "val" : "An endothelial cell found in the mucosa associated with the facial skeleton.",
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      "lbl" : "endothelial cell of sinusoid",
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        "definition" : {
          "val" : "An endothelial cell that lines any of the venous cavities through which blood passes in various glands and organs such as the spleen and liver.",
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      "lbl" : "type A cell of stomach",
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        "definition" : {
          "val" : "A type of enteroendocrine cell found in the stomach that secretes glucagon.",
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          "val" : "colonic delta cell"
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      "lbl" : "type D cell of small intestine",
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          "val" : "A type D cell of the small intestine.",
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          "val" : "small intestine D-cell"
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      "lbl" : "type D cell of stomach",
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      "lbl" : "histamine secreting cell",
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        "definition" : {
          "val" : "A cell type that secretes histamine.",
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        "definition" : {
          "val" : "A PP cell located in the islets of the pancreas.",
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        "comments" : [ "The term PP cell of pancreatic acinus was obsoleted due to a lack of evidence, making PP cell of pancreatic islets synonymous with pancreatic PP cell." ],
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          "val" : "PP-cell of pancreatic islet"
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      "lbl" : "type I cell of carotid body",
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        "definition" : {
          "val" : "A round or oval neuroepithelial cell that contacts other type I cells or capillaries. They occur in clusters that are surrounded by sheath cells (type-II cells) in the carotid body. This cell type is capable of secreting a number of neurotransmitters.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0002294",
      "lbl" : "type-1 epithelial cell of thymus",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell with a well defined Golgi apparatus that makes up the continuous layer of cells bordering the thymic tissue beneath the capsule.",
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          "val" : "subcapsular thymic epithelial cell",
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          "val" : "FMA:72209"
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          "val" : "2010-09-13T02:37:23Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002301",
      "lbl" : "type B synovial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A resident stromal cell located in the synovial membrane and responsible for the production of immune-related cytokines and chemokines. This cell type secretes glycoproteins and hyaluronic acid, has abundant granular endoplasmic reticulum, but contains fewer vacuoles and vesicles.",
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        },
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          "pred" : "hasExactSynonym",
          "val" : "fibroblast-like synoviocyte"
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          "val" : "synovial fibroblast",
          "xrefs" : [ "PMID:23147896" ]
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        "xrefs" : [ {
          "val" : "BTO:0003652"
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          "val" : "2010-09-13T03:39:14Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002305",
      "lbl" : "epithelial cell of distal tubule",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell of the distal convoluted tubule of the kidney that helps regulate systemic levels of potassium, sodium, calcium, and pH.",
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          "val" : "kidney distal tubule epithelial cell"
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        "xrefs" : [ {
          "val" : "FMA:70981"
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          "val" : "KUPO:0001055"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002306",
      "lbl" : "epithelial cell of proximal tubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the proximal tubule of the kidney.",
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        "comments" : [ "The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions." ],
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          "val" : "kidney proximal tubule epithelial cell"
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        "xrefs" : [ {
          "val" : "FMA:70973"
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          "val" : "KUPO:0001044"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002307",
      "lbl" : "brush border cell of the proximal tubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A brush border epithelial cell located in the proximal tubule of the kidney, essential for reabsorbing substances like glucose and amino acids from the glomerular filtrate. These cells also secrete organic ions, playing a crucial role in maintaining kidney homeostasis, including electrolyte and acid-base balance, and excreting metabolic waste.",
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        "comments" : [ "The vast majority of proximal tubule epithelial cells have a brush border, but there are rare exceptions." ],
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          "val" : "2010-09-14T11:29:20Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002308",
      "lbl" : "epithelial cell of skin gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of a skin gland.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of gland of skin"
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        "xrefs" : [ {
          "val" : "FMA:70657"
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          "val" : "2010-09-14T12:00:07Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002309",
      "lbl" : "corticotroph",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basophil chromphil cell of the anterior pitiutary gland that produce adrenocorticotropic hormone, melanocyte-stimulating hormone and lipotropin. This cell type is irregular in shape and has short dendritic processes which are inserted among other neighboring cells;",
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        "xrefs" : [ {
          "val" : "BTO:0002509"
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          "val" : "FMA:83098"
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          "val" : "2010-09-14T02:08:23Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002311",
      "lbl" : "mammotroph",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An acidophilic cell of the anterior pituitary that produces prolactin.",
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        "synonyms" : [ {
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          "val" : "epsilon-acidophil"
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          "val" : "lactotrope"
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          "val" : "lactotroph"
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          "val" : "lactotropic cell"
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          "val" : "mammotrope"
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          "val" : "mammotrophic cell"
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          "pred" : "hasExactSynonym",
          "val" : "mammotropic cell"
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        "xrefs" : [ {
          "val" : "FMA:83096"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002312",
      "lbl" : "somatotroph",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "somatotrope"
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          "val" : "somatotropic cell"
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          "pred" : "hasExactSynonym",
          "val" : "somatrophic cell"
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        "xrefs" : [ {
          "val" : "FMA:83095"
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          "val" : "MESH:D052683"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-14T02:33:09Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002313",
      "lbl" : "endocrine-paracrine cell of prostate gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An ecto-epithelial cell of the prostate gland that secretes hormones.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glandular cell of prostate"
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          "pred" : "hasExactSynonym",
          "val" : "neuro-epithelial cell of prostate gland"
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          "val" : "CALOHA:TS-1280"
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          "val" : "FMA:74390"
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          "val" : "FMA:86774"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002315",
      "lbl" : "supporting cell of cochlea",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial supporting cell located in the cochlea.",
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        "xrefs" : [ {
          "val" : "FMA:79796"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-14T03:31:38Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002316",
      "lbl" : "supporting cell of vestibular epithelium",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A supporting cell of the vestibular epithelium.",
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        },
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        "xrefs" : [ {
          "val" : "FMA:75607"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002319",
      "lbl" : "neural cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A cell that is part of the nervous system.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#general_cell_types_upper_slim" ],
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      "id" : "http://purl.obolibrary.org/obo/CL_0002320",
      "lbl" : "connective tissue cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the supporting or framework tissue of the body, which includes adipose tissue, cartilage, and bone. In vertebrates, this cell arises chiefly from the embryonic mesoderm and, in cranial regions, from neural crest.",
          "xrefs" : [ "GOC:tfm", "ISBN:0618947256", "PMID:19198652", "PMID:26043871", "PMID:31194383" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_0002321",
      "lbl" : "embryonic cell (metazoa)",
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        "definition" : {
          "val" : "A cell of the embryo.",
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        "xrefs" : [ {
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      "id" : "http://purl.obolibrary.org/obo/CL_0002323",
      "lbl" : "amniocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of a fetus which is suspended in the amniotic fluid. Amniocytes are considered to arise from several tissues including fetal skin, the fetal urinary tract, umbilical cord, and the inner amniotic surface.",
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        "definition" : {
          "val" : "A myoepithelial cell that is part of a mammary gland and is located in the basal layer. During lactation, a basal-myoepithelial cell of mammary gland contracts under the stimulation of oxytocin. In humans, a basal-myoepithelial cell of mammary gland can be identified by high levels of CD49f and low levels of EpCAM.",
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        "comments" : [ "Due inconsistencies in naming this and other mammary gland epithelial cell types, several mammary gland experts gathered for a breast atlas annotation jamboree organized by Chan-Zuckerberg initiative. They agreed to label this cell type as basal-myoepithelial cell (and abbreviated: B-Myo cell)." ],
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          "val" : "basal-myoepithelial cell",
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          "pred" : "hasExactSynonym",
          "val" : "myoepithelial cell of mammary gland",
          "xrefs" : [ "PMID:11250738" ]
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          "pred" : "hasNarrowSynonym",
          "val" : "basal cell of lactiferous duct",
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          "pred" : "hasNarrowSynonym",
          "val" : "myoepithelial cell of lactiferous gland"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002325",
      "lbl" : "lactocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A milk-producing glandular epithelial cell that is part of a mammary gland alveolus and differentiates from a luminal adaptive secretory precursor cell during secretory differentiation (also termed lactogenesis I). Following secretory activation (also termed lactogenesis II), a lactocyte is involved in the synthesis and/or transport of milk constituents including proteins, oligosaccharides, lactose, micronutrients, fat, hormones, immunoglobulins, and cytokines into the lumen of the lactating mammary gland.",
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          "val" : "mammary alveolar cell",
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          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of lactiferous gland"
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          "pred" : "hasExactSynonym",
          "val" : "lactaction-associated mammary epithelial cell",
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          "pred" : "hasExactSynonym",
          "val" : "lactation-derived mammary cell",
          "xrefs" : [ "PMID:35091553" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "luminal cell of alveolus of lactiferous gland"
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          "pred" : "hasExactSynonym",
          "val" : "mammary alveolar epithelial cell"
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          "pred" : "hasExactSynonym",
          "val" : "mammary gland alveolar epithelial cell"
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          "val" : "FMA:74506"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002326",
      "lbl" : "luminal epithelial cell of mammary gland",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A mammary epithelial cell that occurs in the lumen of the ductal and alveoli structure in the breast.",
          "xrefs" : [ "GOC:tfm", "PMID:19022771" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_0002327",
      "lbl" : "mammary gland epithelial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell of the mammary gland.",
          "xrefs" : [ "GOC:tfm", "PMID:19022771" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "breast epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mammary epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004300"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-20T01:49:37Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002328",
      "lbl" : "bronchial epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the bronchus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0002922"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-20T02:00:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002329",
      "lbl" : "basal epithelial cell of tracheobronchial tree",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell type that lacks the columnar shape typical for other respiratory epithelial cells. This cell type is able to differentiate into other respiratory epithelial cells in response to injury.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-20T02:10:36Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002332",
      "lbl" : "multiciliated epithelial cell of the bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multi-ciliated epithelial cell located in the bronchus epithelium, characterized by a columnar shape and motile cilia on its apical surface.",
          "xrefs" : [ "GOC:tfm", "PMID:18757316" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ciliated epithelial cell of the bronchus"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-20T02:21:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002333",
      "lbl" : "neural crest derived adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte derived from a neural crest cell.",
          "xrefs" : [ "GOC:tfm", "PMID:17507398" ]
        },
        "basicPropertyValues" : [ {
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        }, {
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          "val" : "2010-09-20T02:25:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002334",
      "lbl" : "preadipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An undifferentiated fibroblast that can be stimulated to form a fat cell.",
          "xrefs" : [ "GOC:tfm", "PMID:18793119" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0001107"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-20T02:31:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002335",
      "lbl" : "brown preadipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A preadipocyte that is capable of differentiating into a brown adipocyte. This cell type expresses uncoupling protein-1, PPAR-gamma, PR-domain-containing 16; and PGC-1alpha (peroxisome proliferator-activated receptor-gamma (PPARgamma) coactivator-1alpha).",
          "xrefs" : [ "GOC:tfm", "PMID:18719589" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-20T02:38:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002336",
      "lbl" : "buccal mucosa cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that lines the oral cavitiy including the mucosa of the gums, the palate, the lip, and the cheek.",
          "xrefs" : [ "GOC:tfm", "MESH:D009061" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-09-20T02:52:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002338",
      "lbl" : "CD56-positive, CD161-positive immature natural killer cell, human",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-positive, CD117-positive, CD122-positive,and CD161-positive.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ]
        },
        "comments" : [ "Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "p-NK",
          "xrefs" : [ "PMID:12457618" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-21T10:06:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002339",
      "lbl" : "prostate stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A prostate epithelial cell that is CD133-positive, CD44-positive, integrin A2beta3-high. This cell is a stem cell for the prostate epithelium.",
          "xrefs" : [ "GOC:tfm", "PMID:15226377" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD133-positive prostate epithelial cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-20T03:21:06Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002341",
      "lbl" : "basal cell of prostate epithelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An undifferentiated cell of the prostate epithelium that lacks secretory activity.",
          "xrefs" : [ "GOC:tfm", "PMCID:PMC2673349" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-20T03:34:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002344",
      "lbl" : "CD56-negative, CD161-positive immature natural killer cell, human",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell that is developmentally immature, has the phenotype CD34-negative, CD56-negative, CD117-positive, CD122-positive,and CD161-positive.",
          "xrefs" : [ "GOC:add", "GO_REF:0000031", "ISBN:0781735149", "PMID:12457618" ]
        },
        "comments" : [ "Human markers; killer cell immunoglobulin-like receptor 2DL1 is used as a representative example (PRO at this time lacks a KIR superfamily)." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "p-NK",
          "xrefs" : [ "PMID:12457618" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-20T04:33:11Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002350",
      "lbl" : "endocardial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that lines the intracavitary lumen of the heart, separating the circulating blood from the underlying myocardium. This cell type releases a number of vasoactive substances including prostacyclin, nitrous oxide and endothelin.",
          "xrefs" : [ "GOC:tfm", "ISSN:0452-3458" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
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          "val" : "endocardial endothelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "endothelial cell of endocardium",
          "xrefs" : [ "FMA:75621" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:75621"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-21T04:33:05Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002351",
      "lbl" : "progenitor cell of endocrine pancreas",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell that is able to differentiate into the pancreas alpha, beta and delta endocrine cells. This cell type expresses neurogenin-3 and Isl-1.",
          "xrefs" : [ "GOC:tfm", "PMID:20025937", "PMID:20217494", "PMID:22728667" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic endocrine progenitor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic islet progenitor cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-21T04:41:06Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002352",
      "lbl" : "gestational hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell that exists during embryogenesis.",
          "xrefs" : [ "GOC:tfm", "ISBN:978-60327-246-6" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T09:05:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002353",
      "lbl" : "fetal liver hematopoietic progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell that resides in the fetal liver. In mice, this cell type is first observed at E10.5. This cell type is MHC-positive, HSA-positive, AA4.1-positive, CD45-positive, Sca-1 positive, CD150-positive, CD48-negative and CD244-negative.",
          "xrefs" : [ "GOC:tfm", "ISBN:978-1-60327-346-6", "PMID:16569764" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T09:08:32Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002354",
      "lbl" : "yolk sac hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem found in the yolk sac. In mice, this cell type is Sca-1-negative, CD45-negative, MHC-negative, HSA-positive, AA4.1-positive, CD44-positive.",
          "xrefs" : [ "GOC:tfm", "doi:10.1097/MOH.0b013e3282f97ae1" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hemangioblast precursor"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T09:08:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002355",
      "lbl" : "primitive red blood cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A large nucleated basophilic erythrocyte found in mammalian embryos. This cell type arises from the blood islands of yolk sacs and expresses different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes. Considered a type of erythroblast as this cell type can enucleate in circulation.",
          "xrefs" : [ "DOI:10.1097/MOH.0b013e3282f97ae1", "GOC:tfm", "PMID:11495698" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "primitive erythroblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "primitive erythrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "primitive erythroid cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T09:27:05Z"
        } ]
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      "id" : "http://purl.obolibrary.org/obo/CL_0002357",
      "lbl" : "fetal derived definitive erythrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fetal liver derived enucleated erythrocyte. This erythrocyte resembles adult erythrocytes in that they are small (3- to 6- times smaller than primitive erythrocytes) and produce adult hemaglobins.",
          "xrefs" : [ "GOC:tfm", "PMID:11495698" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "macrocyte"
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        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T09:38:32Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002359",
      "lbl" : "placental hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hematopoietic stem cell of the placenta. This cell type is first observed E10.5 This cell type may give rise to fetal liver hematopoietic stem cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:978-1-60327-346-6" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T10:30:02Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002361",
      "lbl" : "primitive erythroid progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell that is capable of forming colonies of primitive erythrocytes in the blood island of the yolk sac. First arrive at E7.5 in mouse and expresses CD41.",
          "xrefs" : [ "GOC:tfm", "ISBN:0813817986", "PMID:20711979" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "EryP-CFC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "inner blood island hemangioblast"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T10:47:28Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002362",
      "lbl" : "cerebellar granule cell precursor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell located in the outermost proliferative zone of the external germinal layer that can differentiate into astroglial cells and granule cells. This cell type is glial fibrillary acidic protein-positive and HNK1-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:14745007" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "granule cell precursor",
          "xrefs" : [ "doi:10.3389/fncir.2020.611841" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "granule cell progenitor",
          "xrefs" : [ "doi:10.3389/fncir.2020.611841" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T01:40:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002363",
      "lbl" : "keratocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A keratocyte is a specialized fibroblast residing in the cornea stroma that has a flattened, dendritic morphology; located between the lamellae with a large flattened nucleus, and lengthy processes which communicate with neighboring cells. This corneal layer, representing about 85-90% of corneal thickness, is built up from highly regular collagenous lamellae and extracellular matrix components. Keratocytes play the major role in keeping it transparent, healing its wounds, and synthesizing its components. This cell type secretes collagen I, V, VI, and keratan sulfate.",
          "xrefs" : [ "GOC:tfm", "ISBN:9780702029585" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "corneal fibroblast"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "corneal keratocyte"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-22T01:57:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002364",
      "lbl" : "cortical thymic epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the cortical portion of the thymus. Epithelial cells in this region are required for positive selection of CD8-positive T cells.",
          "xrefs" : [ "GOC:tfm", "PMID:18403190" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cTEC"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004562"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-23T03:17:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002365",
      "lbl" : "medullary thymic epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the medullary thymus. This cell type expresses a diverse range of tissue-specific antigens. This promiscuous gene expression is a cell-autonomous property of medullary epithelial cells and is maintained during the entire period of thymic T cell output.",
          "xrefs" : [ "GOC:tfm", "PMID:18180458" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mTEC"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004563"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-09-23T03:17:14Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002366",
      "lbl" : "myometrial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell of the myometrium that enlarges and stretches during pregnancy, and contracts in response to oxytocin.",
          "xrefs" : [ "GOC:tfm", "PMID:11429640" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "myometrium smooth muscle cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004519"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-23T03:46:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002367",
      "lbl" : "trabecular meshwork cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An ocular connective tissue cell that is part of the eye's trabecular meshwork and is directly responsible for regulating the outflow of aqueous humor from the anterior chamber of the eye, thereby maintaining proper intraocular pressure.",
          "xrefs" : [ "GOC:tfm", "PMID:14500801", "PMID:40136401" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "trabeculocyte"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-23T04:18:50Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002368",
      "lbl" : "respiratory tract epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "airway epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "respiratory epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004533"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-23T04:38:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002370",
      "lbl" : "respiratory tract goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A simple columnar epithelial cell that secretes mucin. Rough endoplasmic reticulum, mitochondria, the nucleus, and other organelles are concentrated in the basal portion. The apical plasma membrane projects microvilli to increase surface area for secretion.",
          "xrefs" : [ "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "respiratory goblet cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "respiratory mucosa goblet cells",
          "xrefs" : [ "MP:0010863" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-23T04:42:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002372",
      "lbl" : "myotube",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transversely striated, multinucleated syncytial muscle cell, formed by the fusion of myoblasts during muscle development.",
          "xrefs" : [ "GOC:dos", "GOC:tfm", "ISBN:0323052908", "PMID:22274696" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "myofiber",
          "xrefs" : [ "FBbt:00005812" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myofibril",
          "xrefs" : [ "FBbt:00005812" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-24T01:13:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002374",
      "lbl" : "ear hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A hair cell of the ear that contains the organs of balance and hearing.",
          "xrefs" : [ "GOC:dph", "GOC:tfm", "ISBN:0192801023" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ear receptor cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-24T01:49:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002375",
      "lbl" : "Schwann cell precursor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multipotent progenitor cell that develops from a migratory neural crest cell. The schwann cell precursor is embedded among axons, with minimal extracellular space separating them from nerve cell membranes. This cell lacks a basal lamina, which distinguishes it from more mature Schwann cells. In rodents, cadherin-19 (Cdh19) serves as a specific marker for this developmental stage.",
          "xrefs" : [ "GOC:tfm", "PMID:15580626", "PMID:30971890", "PMID:35815410" ]
        },
        "comments" : [ "Schwann cell precursor are capable of differentiating into Schwann cells and other cell types such as melanocytes, neurons, and mesenchymal cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Schwann cell precursor cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-24T02:06:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002377",
      "lbl" : "immature Schwann cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glial cell that develops from a Schwann cell precursor. The immature Schwann cell is embedded among neurons (axons) with minimal extracellular spaces separating them from nerve cell membranes and has a basal lamina. Cells can survive without an axon present. Immature Schwann cell can be found communally ensheathing large groups of axons.",
          "xrefs" : [ "GOC:cvs", "GOC:tfm", "ISBN:0721662544" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "Schwann cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
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          "val" : "2010-09-24T02:10:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002393",
      "lbl" : "intermediate monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A monocyte that has characteristics of both patrolling and inflammatory monocytes.",
          "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:20870168" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-04T10:52:03Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002395",
      "lbl" : "Gr1-high classical monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A resident monocyte that is Gr-1 high, CD43-negative, CX3CR1-negative, CD115-positive, and B220-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:27098205", "PMID:8890901", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Markers are associated with mice. The Gr epitope is used to describe this cell type is found on both Ly6c and Ly6g. However, its the Ly6c that is considered the specific marker, and thus used in the cross-product." ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-04T11:26:18Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002397",
      "lbl" : "CD14-positive, CD16-positive monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD14-positive monocyte that is also CD16-positive and CCR2-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:21937707", "PMID:22343568" ]
        },
        "comments" : [ "This cell type is compatible with the HIPC Lyoplate markers for 'CD16+ monocyte'. Markers are associated with human cells. Note that this cell type encompasses both human intermediate monocytes (CD14+, CD16-low), and human non-classical monocytes (CD14-low, CD16+)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD16+ monocyte",
          "xrefs" : [ "PMID:22343568" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-04T12:49:47Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002398",
      "lbl" : "Gr1-positive, CD43-positive monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intermediate monocyte that is Gr1-positive, CD43-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:20628149", "PMID:27098205" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "val" : "2010-10-04T12:49:49Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002400",
      "lbl" : "fraction B/C precursor B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor B cell that is AA4-positive, IgM-negative, CD19-positive, CD43-positive and HSA-positive.",
          "xrefs" : [ "GOC:tfm", "PMID:37442242", "http://www.immgen.org/index_content.html" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "val" : "2010-10-05T10:11:38Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002401",
      "lbl" : "mature dendritic epithelial T cell precursor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that has a T cell receptor consisting of a gamma chain that has as part a Vgamma3 segment, and a delta chain. This cell type is CD4-negative, CD8-negative and CD24-negative. This cell-type is found in the fetal thymus with highest numbers occurring at E17-E18.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "NOTE: currently variable immune gene segments are not represented in the OBO Foundry. Cross-product definitions were not made as a result. Also, there are three different nomenclatures for the variable gamma segments." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature DEC precursor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature DETC precursor"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-10-07T02:05:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002402",
      "lbl" : "Peyer's patch B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A resting mature B cell within the Peyer's patch that is CD19-positive, B220-positive, IgM-positive, AA4-negative, CD23-positive, CD43-negative, and CD5-negative.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Peyers patch B cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-10-05T11:18:03Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002404",
      "lbl" : "fetal thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte found in the fetal thymus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "val" : "2010-10-07T02:28:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002417",
      "lbl" : "primitive erythroid lineage cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An immature or mature cell of the first erythroid lineage to arise during embryonic development.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "val" : "2010-10-12T11:22:41Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002418",
      "lbl" : "hemangioblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pluripotent cell in the yolk sac that can give rise to mesenchymal cells including erythrocytes and endothelial cells.",
          "xrefs" : [ "GOC:tfm", "ISBN:0813817986", "PMID:11495698" ]
        },
        "xrefs" : [ {
          "val" : "MESH:D055018"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-12T12:21:16Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002419",
      "lbl" : "mature T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that expresses a T cell receptor complex and has completed T cell selection.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD3e-positive T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature T-cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CD3epsilon T cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-12T01:56:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002420",
      "lbl" : "immature T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that has not completed T cell selection.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature T-cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001372"
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          "val" : "CALOHA:TS-1042"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-12T01:56:17Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002421",
      "lbl" : "nucleated reticulocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A reticulocyte that retains the nucleus and other organelles. Found in birds, fish, amphibians and reptiles.",
          "xrefs" : [ "GOC:tfm", "PMID:18182572", "PMID:9011180", "PMID:9046052" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-10-15T09:24:05Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002422",
      "lbl" : "enucleated reticulocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A reticulocyte lacking a nucleus and showing a basophilic reticulum under vital staining due to the presence of ribosomes.",
          "xrefs" : [ "GOC:tfm", "ISBN:0-12203-052-4", "ISBN:0721601464" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0864"
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          "val" : "FMA:66785"
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        "basicPropertyValues" : [ {
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          "val" : "2010-10-15T09:24:08Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002425",
      "lbl" : "early T lineage precursor",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A pro-T cell that is lin-negative, CD25-negative, CD127-negative, CD44-positive and kit-positive.",
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        },
        "comments" : [ "ETPs are reportedly CD1a-negative, CD4-negative, CD7-positive, CD8a-negative, CD8b-negative, CD33-low, CD34-high, CD38-low, CD45RA-positive, and CD45RO-negative." ],
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ETP"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "preT.ETP.Th"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T01:16:24Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002427",
      "lbl" : "resting double-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double-positive, alpha-beta thymocyte that is small and not proliferating.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
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          "val" : "T.DP.sm.Th"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002428",
      "lbl" : "double-positive blast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double-positive thymocyte that is large (i.e. has a high forward scatter signal in flow cytometry) and is actively proliferating.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T.DPb.Th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "activated double-positive thymocyte"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T01:59:11Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002429",
      "lbl" : "CD69-positive double-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double-positive thymocyte that is CD69-positive and has begun positive selection.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
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          "val" : "T.DP69+.Th"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-10-21T02:11:52Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002430",
      "lbl" : "CD4-intermediate, CD8-positive double-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD4 co-receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T.4int8+.Th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T_4int8+_Th"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T02:29:19Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002431",
      "lbl" : "CD4-positive, CD8-intermediate double-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A double-positive thymocyte that is undergoing positive selection, has high expression of the alpha-beta T cell receptor, is CD69-positive, and is in the process of down regulating the CD8 co-receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T.4+8int.Th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T_4+8int_Th"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-10-21T02:29:23Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002432",
      "lbl" : "CD24-positive, CD4 single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, CD8-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Described in the immgene database as being CD24-intermediate." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD24-positive, CD4 single-positive semimature thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T.4SP24int.Th"
        } ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-10-21T02:43:52Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002433",
      "lbl" : "CD69-positive, CD4-positive single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive, CD8-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T.4SP69+.Th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intermediate CD4-single-positive"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T02:46:02Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002434",
      "lbl" : "CD24-positive, CD8 single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, CD4-negative thymocyte that is CD24-positive and expresses high levels of the alpha-beta T cell receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "comments" : [ "Described in the immgene database as being CD24-intermediate." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD24-positive, CD8 single-positive semimature thymocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T.8SP24int.Th"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T02:59:10Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002435",
      "lbl" : "CD69-positive, CD8-positive single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD8-positive, CD4-negative thymocyte that expresses high levels of the alpha-beta T cell receptor and is CD69-positive.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html", "https://orcid.org/0000-0001-5208-3432" ]
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        "synonyms" : [ {
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          "val" : "T.8SP69+.Th"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intermediate CD8-single-positive"
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        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T02:59:14Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002436",
      "lbl" : "mature CD4 single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature CD4-positive, CD8-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T03:31:19Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002437",
      "lbl" : "mature CD8 single-positive thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mature CD8-positive, CD4-negative alpha-beta T cell found in the thymus that is CD24-low and has high expression of the T cell receptor.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T.8SP24-.Th"
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        "basicPropertyValues" : [ {
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          "val" : "2010-10-21T03:51:50Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002453",
      "lbl" : "oligodendrocyte precursor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A proliferative and migratory glial progenitor cell that derives from a neural stem cell and resides within the central nervous system. It possesses the capacity to differentiate into a committed oligodendrocyte progenitor (COP) through a well-defined series of maturation steps, ultimately giving rise to a myelinating oligodendrocyte (MOL). In mice and humans, it is characterized by the expression of specific molecular markers, including Pdgfra, Cspg4 (also known as NG2) and Olig2.",
          "xrefs" : [ "GOC:tfm", "PMID:16367798", "PMID:20142420", "PMID:31583586", "PMID:31726662", "PMID:37653126" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "NG2 cell",
          "xrefs" : [ "PMID:14501223" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Polydendrocyte",
          "xrefs" : [ "PMID:23516142" ]
        } ],
        "xrefs" : [ {
          "val" : "MESH:D000073637"
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        "basicPropertyValues" : [ {
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          "val" : "2010-11-10T02:51:34Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002454",
      "lbl" : "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "CD4-negative, CD8-alpha-negative, CD11b-positive dendritic cell is a conventional dendritic cell that is CD11b-positive, CD4-negative, CD8-alpha-negative and is CD205-positive.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DC.8-4-11b+"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "spleen double-negative dendritic cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2010-11-22T01:10:28Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002457",
      "lbl" : "epidermal Langerhans cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Langerhans cell that is in the epidermis and is CD45-positive, MHCII-positive, and CD11b-positive.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "2010-11-22T03:57:57Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002460",
      "lbl" : "CD8-alpha-negative thymic conventional dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A conventional thymic dendritic cell that is CD8-alpha-negative.",
          "xrefs" : [ "GOC:tfm", "PMID:19273629", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DC.8-.Th"
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        "basicPropertyValues" : [ {
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          "val" : "2010-11-23T10:58:53Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002465",
      "lbl" : "CD11b-positive dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A conventional dendritic cell that expresses CD11b (ITGAM).",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-11-23T01:50:05Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002467",
      "lbl" : "Gr1-high myeloid suppressor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myeloid suppressor cell that is Gr1-high and CD11c-negative.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MDS.Gr1hi"
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          "val" : "2010-11-23T02:15:12Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002468",
      "lbl" : "Gr1-low myeloid suppressor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myeloid suppressor cell that is Gr1-low and CD11c-positive.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MDS.Gr1lo"
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        "basicPropertyValues" : [ {
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          "val" : "2010-11-23T02:19:43Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002469",
      "lbl" : "MHC-II-negative classical monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Gr1-high monocyte that lacks MHC-II receptor complex.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Mo.6C+II-"
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          "val" : "2010-11-23T03:27:12Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002470",
      "lbl" : "MHC-II-positive classical monocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Gr1-high monocyte that has a MHC-II receptor complex.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002480",
      "lbl" : "nasal mucosa goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell located in the nasal epithelium.",
          "xrefs" : [ "GOC:cjm", "GOC:tfm" ]
        },
        "comments" : [ "The marker set LYPD2, MUC5AC can identify the Human cell type nasal mucosa goblet cell in the lung with a confidence of 0.81 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002481",
      "lbl" : "peritubular myoid cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule.",
          "xrefs" : [ "GOC:cjm", "GOC:tfm", "MP:0006420" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:11:48Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002482",
      "lbl" : "dermal melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte that produces pigment in the dermis.",
          "xrefs" : [ "GOC:cjm", "GOC:tfm", "MP:0009386" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:17:05Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002483",
      "lbl" : "hair follicle melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte that produces pigment within the hair follicle.",
          "xrefs" : [ "GOC:tfm", "MP:0004381" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:17:09Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002484",
      "lbl" : "epithelial melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte that produces pigment in the epithelium.",
          "xrefs" : [ "GOC:tfm", "MP:0009388" ]
        },
        "comments" : [ "The text defintion reference to the MP term appears to reference an epidermal melanocyte term. This term represents any melanocyte in any epithelium." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:17:14Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002485",
      "lbl" : "retinal melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte of the retina. This cell type is distinct from pigmented retinal epithelium.",
          "xrefs" : [ "GOC:tfm", "MP:0010190" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:25:32Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002486",
      "lbl" : "strial intermediate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV) .",
          "xrefs" : [ "GOC:tfm", "MP:0000048" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-03T03:29:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002487",
      "lbl" : "cutaneous/subcutaneous mechanoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuronal receptor that respond to mechanical pressure or distortion in the skin.",
          "xrefs" : [ "GOC:tfm", "MP:0000973" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T02:53:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002488",
      "lbl" : "trophoblast giant cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A trophoblast cell that has a large volume of cytoplasm, is polyploid and is usually mononuclear but is also occasionally multi-nucleate. This cell type is important in establishing maternal physiology and remodeling of the vasculature of the placenta.",
          "xrefs" : [ "GOC:tfm", "MP:0001714", "MP:19876834" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "giant trophoblast cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T02:55:24Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002489",
      "lbl" : "double negative thymocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A thymocyte that lacks expression of CD4 and CD8.",
          "xrefs" : [ "GOC:tfm", "MP:0002407" ]
        },
        "comments" : [ "These are precursors to mature T cells; normally, they do not circulate, but are found in the thymus and they have not undergone rearrangement of the alpha and beta T cell receptor genes." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4-CD8- T cell",
          "xrefs" : [ "MP:0002407" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "double negative T cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T03:03:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002490",
      "lbl" : "organ of Corti supporting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supporting cell of the organ of Corti.",
          "xrefs" : [ "GOC:tfm", "MP:0004300" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T03:09:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002491",
      "lbl" : "auditory epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized cell involved in auditory sensory perception.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T03:18:43Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002492",
      "lbl" : "strial marginal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A polarized columnar cell that covesr the lateral surface of the cochlear duct, secretes potassium ions and forms a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria.",
          "xrefs" : [ "GOC:tfm", "MP:0004366" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T03:20:41Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002493",
      "lbl" : "strial basal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A polarized cell that is juxtaposed to fibrocytes in the underlying spiral ligament. This cell type secretes potassium ions derived from fibrocytes through gap junctions.",
          "xrefs" : [ "GOC:tfm", "MP:0004365" ]
        },
        "comments" : [ "Basal cells form a multi-layered epithelial barrier that separates the extracellular spaces of the stria vascularis and the spiral ligament[PMID:18353863]" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-06T03:26:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002494",
      "lbl" : "cardiocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell located in the heart, including both muscle and non muscle cells.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "From Onard of the FMA: Cardiac muscle cell or cardiac myocyte is a striated muscle cell. Cardiocyte on the other hand is any cell in the heart which includes cells other than muscle cells (e.g. endothelial cell of endocardium). Unless there is a consensus among anatomists that cardiocytes refer only to muscle cells, we will treat them as a general class of cells in the heart." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "heart cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001539"
        }, {
          "val" : "CALOHA:TS-0115"
        }, {
          "val" : "FMA:83808"
        }, {
          "val" : "FMA:84791"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-07T09:37:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002495",
      "lbl" : "fetal cardiomyocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fetal and neonatal heart cell that undergoes proliferation and is not yet terminally differentiated into a binucleate or a multinucleate cardiac myocyte.",
          "xrefs" : [ "GOC:tfm", "MP:0008788" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "embryonic cardiomyocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neonatal cardiomyocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-07T09:50:41Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002496",
      "lbl" : "intraepithelial lymphocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident lymphocyte located within the epithelial layer of mucosal tissues, particularly within the gastrointestinal, respiratory, and reproductive tracts. Characterised by permanent residency, this cell typically expresses CD103 (integrin alpha-E), which binds to E-cadherin on epithelial cells, enabling epithelial retention in both mice and humans. Phenotypically, IEL displays an activated, antigen-experienced state characterised by the constitutive expression of cytotoxic molecules (granzyme B, perforin) and innate-like receptors (such as NKG2D), enabling rapid, localised surveillance and immediate response to epithelial stress.",
          "xrefs" : [ "GOC:tfm", "MP:0008894", "PMID:29674648", "WIKIPEDIA:Intraepithelial_lymphocyte" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "IEL"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intraepithelial T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intraepithelial T-cell"
        } ],
        "xrefs" : [ {
          "val" : "MESH:D000075942"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-07T09:54:50Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002499",
      "lbl" : "spongiotrophoblast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A trophoblast cell that arises in the junctional zone (basal plate) of the placenta.",
          "xrefs" : [ "GOC:tfm", "MP:0008959" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "spongiotrophoblast"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-07T12:56:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002503",
      "lbl" : "adventitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the adventitial layer of ductal structures such as the uterer, defent duct, biliary duct, etc",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0002441"
        }, {
          "val" : "FMA:84639"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-12-07T04:03:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002504",
      "lbl" : "enteric smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell of the intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intestinal smooth muscle cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-01-17T03:39:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002507",
      "lbl" : "langerin-positive lymph node dendritic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dermal dendritic cell isolated from skin draining lymph nodes that is langerin-positive, MHC-II-positive, and CD4-negative and CD8a-negative.",
          "xrefs" : [ "GOC:tfm", "http://www.immgen.org/index_content.html" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-01-21T01:57:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002518",
      "lbl" : "kidney epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the kidney.",
          "xrefs" : [ "GOC:tfm", "KUPO:SJ" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001019"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-02-08T10:46:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002521",
      "lbl" : "subcutaneous adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of subcutaneous adipose tissue.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "subcutaneous fat cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-02-21T02:51:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002522",
      "lbl" : "renal filtration cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A renal filtration cell is a specialized cell of the renal system that filter fluids by charge, size or both.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-02-08T01:37:59Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002523",
      "lbl" : "mesonephric podocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the mesonephros.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mesonephric glomerular visceral epithelial cell",
          "xrefs" : [ "ZFA:0001674" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2244-7917"
        }, {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-02-08T01:58:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002525",
      "lbl" : "metanephric podocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the metanephros.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "metanephric glomerular visceral epithelial cell",
          "xrefs" : [ "doi:10.1007/s004180050142" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-02-08T02:02:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002535",
      "lbl" : "epithelial cell of cervix",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the cervix.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cervical canal epithelial cell",
          "xrefs" : [ "GOC:tfm" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cervical canal of uterus epithelial cell",
          "xrefs" : [ "GOC:tfm" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cervix epithelial cell",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "cervix of uterus epithelial cell",
          "xrefs" : [ "GOC:tfm" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of cervical canal",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of cervical canal of uterus",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of cervix of uterus",
          "xrefs" : [ "GOC:tfm" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of neck of uterus",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of uterine cervix",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "neck of uterus epithelial cell",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "uterine cervix epithelial cell",
          "xrefs" : [ "GOC:tfm" ]
        } ],
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          "val" : "2011-02-24T08:20:08Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002536",
      "lbl" : "epithelial cell of amnion",
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
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          "val" : "amniotic epithelial cell"
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          "val" : "2011-02-28T12:38:01Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002537",
      "lbl" : "amnion mesenchymal stem cell",
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        "definition" : {
          "val" : "A mesenchymal stem cell of the amnion membrane.",
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          "val" : "amniotic membrane stem cell"
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          "val" : "2011-02-28T12:44:24Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002538",
      "lbl" : "intrahepatic cholangiocyte",
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          "val" : "small bile duct cholangiocyte",
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          "val" : "2011-02-28T01:20:20Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002539",
      "lbl" : "aortic smooth muscle cell",
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          "val" : "2011-02-28T01:42:12Z"
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      "lbl" : "mesenchymal stem cell of the bone marrow",
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        "basicPropertyValues" : [ {
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          "val" : "2011-02-28T01:47:47Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002541",
      "lbl" : "chorionic membrane mesenchymal stem cell",
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          "val" : "2011-02-28T03:04:35Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0002543",
      "lbl" : "vein endothelial cell",
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          "val" : "endothelial cell of vein"
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          "pred" : "hasExactSynonym",
          "val" : "venous endothelial cell"
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          "val" : "2011-02-28T03:48:11Z"
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      "lbl" : "fibroblast of the aortic adventitia",
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          "val" : "cardiac fibroblast"
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        "definition" : {
          "val" : "A fibroblast that is part of the mammary gland.",
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      "lbl" : "fibroblast of periodontium",
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        "basicPropertyValues" : [ {
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      "lbl" : "hair follicle cell",
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        "basicPropertyValues" : [ {
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        "basicPropertyValues" : [ {
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          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:11:26Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002607",
      "lbl" : "migratory enteric neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neural crest cell that gives rise to cells of the enteric nervous system.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:24:35Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002608",
      "lbl" : "hippocampal neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron with a soma found in the hippocampus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:31:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002610",
      "lbl" : "raphe nuclei neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the raphe nuclei.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:42:06Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002611",
      "lbl" : "neuron of the dorsal spinal cord",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CNS neuron of the dorsal spinal cord.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:43:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002612",
      "lbl" : "neuron of the ventral spinal cord",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the ventral spinal cord.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:46:03Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002613",
      "lbl" : "striatum neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the striatum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:47:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002614",
      "lbl" : "neuron of the substantia nigra",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the substantia nigra.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-06T07:48:42Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002615",
      "lbl" : "adipocyte of omentum tissue",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of omentum tissue.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "omental adipocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "omental fat cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T10:17:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002617",
      "lbl" : "adipocyte of breast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of the breast.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "Adipocytes found in the subcutaneous adipose tissue of breast. The breast consists of three main components, the skin, the subcutaneous adipose tissue and the functional glandular tissue that comprises both parenchyma and stroma.[CALOHA]" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "breast adipocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fat cell of breast"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2377"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T10:17:07Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002618",
      "lbl" : "endothelial cell of umbilical vein",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell of the umbilical vein.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "BTO:0004296"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T11:36:51Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002620",
      "lbl" : "skin fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast of skin.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "BTO:0001255"
        }, {
          "val" : "CALOHA:TS-0935"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T12:31:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002621",
      "lbl" : "gingival epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any stratified squamous epithelial cell that is part of some gingival epithelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T12:46:28Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002622",
      "lbl" : "prostate stromal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell of the prostate.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "BTO:0003972"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T02:11:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002623",
      "lbl" : "acinar cell of salivary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An acinar cell that is part of the salivary gland epithelium, responsible for synthesizing and secreting the primary saliva essential for oral digestion, antimicrobial defense, and mucosal immunity. It features apical-basal polarity with apical secretory granules, and tight junctions that maintain polarity and regulate calcium-dependent saliva exocytosis triggered by parasympathetic and sympathetic signals (Ambudkar, 2015). This cell functions in coordination with contractile myoepithelial cells, which aid saliva flow through the ducts into the oral cavity (Khan et al., 2022). In mice and humans, acinar cell development relies on the transcription factor SOX2 (Emmerson et al., 2017), with self-renewal achieved primarily through acinar cell self-duplication and supported by progenitor populations during injury and regeneration (Aure et al., 2016).",
          "xrefs" : [ "GOC:tfm", "PMID:24646566", "PMID:25843887", "PMID:28623666", "PMID:34989394", "PMID:35343828" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "salivary acinar cell",
          "xrefs" : [ "PMID:24646566" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "salivary gland acinar cell",
          "xrefs" : [ "PMID:24646566" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-03-14T02:22:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002625",
      "lbl" : "seminiferous tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the seminiferous tubule epithelium.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2011-03-15T11:59:23Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002631",
      "lbl" : "epithelial cell of upper respiratory tract",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of some upper respiratory tract epithelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-06-21T12:28:55Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002632",
      "lbl" : "epithelial cell of lower respiratory tract",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of some lower respiratory tract epithelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2011-06-21T12:29:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002633",
      "lbl" : "respiratory basal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell in the respiratory tract.",
          "xrefs" : [ "GOC:tfm", "PMID:20699479" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "airway basal cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "airway basal stem cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "val" : "2011-06-21T03:11:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002634",
      "lbl" : "epithelial cell of anal column",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the anal column.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2011-07-08T12:11:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002637",
      "lbl" : "keratinized epithelial cell of the anal canal",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the anal canal that is keratinized. This cell type is found towards the lower, rectal end of the anal canal.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2011-07-08T02:08:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002638",
      "lbl" : "bronchioalveolar stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A respiratory stem cell found at the junction of the terminal (conductive) bronchiole and the respiratory bronchiole. This cell types gives rise to alveolar cell types and club cells in response to lung injury. This cell type expresses markers Scgb1a1 and Sftpc.",
          "xrefs" : [ "GOC:tfm", "MP:0011691", "PMID:15960971" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "BASC"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "basal epithelial cell of bronchioalveolar duct junction"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "http://orcid.org/0000-0001-7258-9596"
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        }, {
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          "val" : "2011-06-21T03:26:08Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002653",
      "lbl" : "squamous endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A squamous shaped endothelial cell.",
          "xrefs" : [ "GOC:dos" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2011-07-08T03:31:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002656",
      "lbl" : "glandular endometrial unciliated epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glandular epithelial cell of the endometrium. Following ovulation, these cells secrete a glycogen-rich substance known as histotroph or uterine milk, which nourishes the embryo if implantation occurs.",
          "xrefs" : [ "GOC:tfm", "PMID:25023676" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "glandular cell of endometrium"
        } ],
        "xrefs" : [ {
          "val" : "FMA:86489"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-08T03:54:08Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002657",
      "lbl" : "glandular cell of esophagus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glandular epithelial cell of the esophagus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:86548"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-1980-3228"
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          "val" : "2011-07-08T03:55:57Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002658",
      "lbl" : "glandular cell of the large intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glandular epithelial cell of the large intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:87194"
        } ],
        "basicPropertyValues" : [ {
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        }, {
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          "val" : "2011-07-08T04:03:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002659",
      "lbl" : "glandular epithelial cell of stomach",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glandular epithelial cell that is part of the stomach.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glandular cell of stomach"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1284"
        }, {
          "val" : "FMA:86554"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2011-07-11T01:20:35Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002663",
      "lbl" : "myocardial endocrine cell of atrium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myocardial endocrine cell that is part of the atrium.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83389"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2011-07-11T02:45:39Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002664",
      "lbl" : "cardioblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that can give rise to multiple cell types (i.e. smooth muscle, endothelial) in the developing heart.",
          "xrefs" : [ "GOC:tfm", "PMID:19745164" ]
        },
        "comments" : [ "Discrepancy in develops from origins prevents me from making the assertion that cardioblasts give rise to all instances of cardiocytes as we state cardiac muscle cells develop from cardiac myoblast, which in turn develop from muscle stem cell." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cardiovascular progenitor cell",
          "xrefs" : [ "PMID:17519333", "PMID:19745164" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:15:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002665",
      "lbl" : "otic fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesenchymal cell within the inner ear, specifically localised to supportive connective tissues such as the spiral ligament and spiral limbus. This cell has specialised structural and molecular adaptations, and it contributes to the homeostasis of the cochlear environment by participating in ionic regulation crucial for auditory function.",
          "xrefs" : [ "GOC:tfm", "PMID:18353863", "PMID:37720106" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "cochlear fibrocyte",
          "xrefs" : [ "PMID:34436572" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:35:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002666",
      "lbl" : "type II spiral ligament fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A spiral ligament fibrocyte that is located near the spiral prominence between the basilar crest and the stria and plays an important role in potassium recycling by actively pumping K+ from the extracellular space and facilitating transcellular K+ transport through gap junctions toward Type I fibrocytes. In mice, Type II fibrocytes express connexin 26 (Gjb2) and connexin 30 (Gjb6) as part of the mesenchymal gap junction system, as well as the Na‑K‑2Cl cotransporter NKCC1.",
          "xrefs" : [ "GOC:tfm", "PMID:18353863", "PMID:19080786", "PMID:33193034" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "type 2 otic fibrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 2 spiral ligament fibrocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:40:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002668",
      "lbl" : "type IV spiral ligament fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A spiral ligament fibrocyte that is located in the triangular space inferior to the crista basilaris (basilar crest). This cell is spindle-shaped and expresses NKCC1 but minimal to no Na,K-ATPase (ATP1A1, ATP1B1) in mice and humans, and lacks connexin 26/30 in mice, indicating it does not participate in K⁺ recycling, unlike type II fibrocytes. Type IV fibrocyte is uniquely characterised by strong expression of connective tissue growth factor (CTGF) in mice, suggesting roles in tissue remodelling and paracrine signalling to other cochlear cells.",
          "xrefs" : [ "GOC:tfm", "PMID:18353863", "PMID:19277783", "PMID:33193034" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "type 4 otic fibrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 4 spiral ligament fibrocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:40:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002669",
      "lbl" : "type III spiral ligament fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A spiral ligament fibrocyte that is located in the deepest part of the inferior spiral ligament, directly lining the bony otic capsule. Distinguished from ion-transporting Type I and II fibrocytes, it utilises actin-myosin stress fibres and anchoring interactions to regulate basilar membrane tension. It has an elongated morphology, is most numerous in the basal, high-frequency cochlea, and expresses contractile and cytoskeletal proteins in mice, including α‑smooth muscle actin, non‑muscle myosin II, caldesmon, and the water channel Aquaporin‑1(Mahendrasingam et al., 2011; Kelly et al., 2012).",
          "xrefs" : [ "GOC:tfm", "PMID:18353863", "PMID:22043022", "PMID:22476723", "PMID:33193034" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "type 3 otic fibrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tension fibroblast",
          "xrefs" : [ "PMID:33193034" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 3 spiral ligament fibrocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:40:50Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002670",
      "lbl" : "type I spiral ligament fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A spiral ligament fibrocyte that underlies the stria vascularis and is part of a mesenchymal gap junction network that regulates ionic homeostasis of the endolymph. In mice, expression of connexin 26 (Gjb2) and connexin 30 (Gjb6) serves as a distinguishing molecular signature.",
          "xrefs" : [ "GOC:tfm", "PMID:18353863", "PMID:18581144", "PMID:33193034" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "type 1 otic fibrocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "type 1 spiral ligament fibrocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-07-11T03:39:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002672",
      "lbl" : "retinal progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multi-fate stem cell that can give rise to different retinal cell types including rod and cone cells.",
          "xrefs" : [ "GOC:tfm", "PMID:20959166", "PMID:21148186" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-08-16T02:38:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002673",
      "lbl" : "tongue muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A skeletal muscle cell that is part of the tongue.",
          "xrefs" : [ "GOC:tfm", "PMID:18816858" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-08-16T03:10:02Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002676",
      "lbl" : "neural crest derived neuroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroblast derived from a neural crest cell.",
          "xrefs" : [ "GOC:tfm", "PMID:17407019" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-08-22T09:24:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002680",
      "lbl" : "PP cell of intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A PP cell found in intestine.",
          "xrefs" : [ "GOC:tfm", "PMID:2420136", "PMID:728970" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-1980-3228"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-09-27T11:59:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0002681",
      "lbl" : "kidney cortical cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a cortex of kidney."
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-0956-8634"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-10-25T03:49:41Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005000",
      "lbl" : "spinal cord interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CNS interneuron located in the spinal cord.",
          "xrefs" : [ "CL:CVS" ]
        },
        "comments" : [ "Is_a interneuron, part_of UBERON:0002240." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005006",
      "lbl" : "ionocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Specialized epithelial cells involved in the maintenance of osmotic homeostasis. They are characterized by abundant mitochondria and ion transporters. In amniotes, they are present in the renal system. In freshwater fish, ionocytes in the skin and gills help maintain osmotic homeostasis by absorbing salt from the external environment.",
          "xrefs" : [ "PMID:17555741", "PMID:19268451" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005008",
      "lbl" : "macular hair cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An auditory hair cell located in the macula that is sensitive to auditory stimuli.",
          "xrefs" : [ "GO:cvs" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005009",
      "lbl" : "renal principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cuboidal epithelial cell of the kidney which regulates sodium and potassium balance. The activity of sodium and potassium channels on the apical membrane of the cell is regulated by aldosterone and vasopressin. In mammals this cell type is located in the renal collecting duct system.",
          "xrefs" : [ "CL:CVS" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005010",
      "lbl" : "renal intercalated cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cuboidal epithelial cell of the kidney that regulates acid/base balance.",
          "xrefs" : [ "CL:CVS" ]
        },
        "comments" : [ "Intercalated cells are also called “mitochondria-rich cells”, reflecting the high levels of round mitochondria at their apical pole, or in their cytoplasm, a distribution that is quite different from that of other kidney tubule cells, which accumulated mitochondria around the basolateral membrane. These cells also have numerous irregular apical microvilli compared with the surrounding segment-specific cells. Intercalated cells lack a central cilium, at least in the cortex, which also differentiates them from the adjacent principal cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intercalated cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:86560"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005012",
      "lbl" : "multiciliated epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A columnar/cuboidal epithelial cell with multiple motile cilia on its apical surface. These cells facilitate the movement of liquids such as mucus or cerebrospinal fluid across the epithelial surface.",
          "xrefs" : [ "CL:CVS", "PMID:28400610", "PMID:30422572", "PMID:38032388" ]
        },
        "comments" : [ "While the term 'multi-ciliated epithelial cell' refers to cells with multiple motile cilia, there are exceptions where epithelial cells may have multiple non-motile cilia. Examples include olfactory sensory neurons, which have non-motile cilia for sensory detection, and choroid plexus epithelial cells, which possess multiple non-motile cilia with transient motility during development. Multiciliated cells are essential for human health, and their dysfunction can lead to various diseases known as ciliopathies, such as primary ciliary dyskinesia. This condition affects the respiratory system, brain ventricles, and reproductive system, leading to chronic respiratory infections, hydrocephalus, and infertility" ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "multi-ciliated cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "multiciliated cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multi-ciliated epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "multiciliated epithelial cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005014",
      "lbl" : "auditory epithelial supporting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A non-sensory cell that extends from the basement membrane to the apical surface of the auditory epithelium and provides support for auditory hair cells.",
          "xrefs" : [ "CL:CVS", "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "auditory epithelial support cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005018",
      "lbl" : "ghrelin secreting cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that secretes ghrelin, the peptide hormone that stimulates hunger.",
          "xrefs" : [ "CL:curator" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005019",
      "lbl" : "pancreatic epsilon cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Ghrelin secreting cells found in the endocrine pancreas.",
          "xrefs" : [ "PMID:14970313" ]
        },
        "comments" : [ "In mammals the endocrine pancreas is called the Islets of Langerhans." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic E cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005020",
      "lbl" : "lymphangioblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Lymphatic progenitor cells.",
          "xrefs" : [ "CL:CVS" ]
        },
        "comments" : [ "Usually express Prox1, or prox1b." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2244-7917"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-01-12T04:44:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005022",
      "lbl" : "vascular lymphangioblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Lymphatic progenitor cells, derived from the veins, that give rise to lymphatic endothelial cells.",
          "xrefs" : [ "CL:CVS" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "parachordal lymphangioblast"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2244-7917"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-01-12T05:21:09Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005024",
      "lbl" : "somatomotor neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A motor neuron that innervates a skeletal muscle.  These motor neurons are all excitatory and cholinergic.",
          "xrefs" : [ "ZFIN:CVS" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "somatic motor neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0005026",
      "lbl" : "hepatoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Multi fate stem cell that gives rise to both hepatocytes and cholangiocytes as descendants. The term often refers to fetal precursors of hepatocytes (differently from 'hepatic stem cell', usually applied to the self-renewing pool of hepatocyte precursors in the adult liver). Hepatoblasts may also be endogenous, as some stem cells found in the liver come from the bone marrow via blood circulation.",
          "xrefs" : [ "GOC:CVS", "PMID:18356246", "PMID:20483998", "PMID:26798363", "https://orcid.org/0000-0003-1940-6740" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0007000",
      "lbl" : "preameloblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that has the potential to develop into an ameloblast. Located in the inner enamel epithelium, these cells elongate, their nuclei shift distally (away from the dental papilla), and their cytoplasm becomes filled with organelles needed for synthesis and secretion of enamel proteins.",
          "xrefs" : [ "GO_REF:0000034", "PMCID:PMC2737325" ]
        },
        "comments" : [ "unsure of neural crest contribution. In VSAO we have develops_from CL:0000008" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9114-8737"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-06-15T01:27:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0007001",
      "lbl" : "skeletogenic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell that has the potential to form a skeletal cell type (e.g. cells in periosteum, cells in marrow) and produce extracellular matrix (often mineralized) and skeletal tissue (often mineralized).",
          "xrefs" : [ "GO_REF:0000034" ]
        },
        "comments" : [ "Needs logical definition. Should be capable_of skeletal system morphogenesis? or skeletal tissue development? needs to be added to GO. NOTES:a cell type of the early embryo (see also: mesenchymal cells) that will give rise to mineralized connective tissue. Scleroblasts can differentiate into osteoblasts (bone-forming cells), chondroblasts (cartilage-forming cells), odontoblasts (dentin-forming cells), ameloblasts (enamel-forming cells). The mesenchymal cells developing into osteoblasts and chondroblasts are derived from the mesoderm. Those developing into odontoblasts are neural crest cells. Those developing into ameloblasts are derived from the ectoderm. (http://www.copewithcytokines.de/cope.cgi?key=scleroblasts)" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "scleroblast",
          "xrefs" : [ "GO_REF:0000034" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9114-8737"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-06-15T02:51:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0007002",
      "lbl" : "precementoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that has the potential to develop into a cementoblast.",
          "xrefs" : [ "GO_REF:0000034" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9114-8737"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-06-15T04:37:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0007003",
      "lbl" : "preodontoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that has the potential to form an odontoblast, deposits predentine, and arises from a cranial neural crest cell.",
          "xrefs" : [ "GO_REF:0000034" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-9114-8737"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-06-15T05:15:11Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0007004",
      "lbl" : "premigratory neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell that is part of the neural crest region of the neuroepithelium, prior to migration. Note that not all premigratory neural crest cells may become migratory neural crest cells.",
          "xrefs" : [ "UBERONREF:0000002" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/CL_0007009",
      "lbl" : "prechondroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that has the potential to develop into a chondroblast; and arises from neural crest, meseosdermal and notochordal and connective tissue cells.",
          "xrefs" : [ "GO_REF:0000034" ]
        },
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      "id" : "http://purl.obolibrary.org/obo/CL_0007010",
      "lbl" : "preosteoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Skeletogenic cell that has the potential to transform into an osteoblast, and develops from neural crest or mesodermal cells.",
          "xrefs" : [ "GO_REF:0000034" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "osteoprogenitor cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2012-06-27T10:57:21Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0007011",
      "lbl" : "enteric neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Neuron that is part of the enteric nervous system.",
          "xrefs" : [ "CL:MAH" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/CL_0008000",
      "lbl" : "non-striated muscle cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any muscle cell in which the fibers are not organised into sarcomeres.",
          "xrefs" : [ "GOC:DOS" ]
        }
      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0008001",
      "lbl" : "hematopoietic precursor cell",
      "type" : "CLASS",
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        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
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      "lbl" : "skeletal muscle fiber",
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          "val" : "A transversely striated, synctial cell of skeletal muscle. It is formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
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      "id" : "http://purl.obolibrary.org/obo/CL_0008007",
      "lbl" : "visceral muscle cell",
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          "xrefs" : [ "GOC:dos" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0008008",
      "lbl" : "striated visceral muscle cell",
      "type" : "CLASS",
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          "val" : "A visceral muscle cell that is striated.  Examples include the visceral muscle cells of arhtropods.",
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        }
      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0008009",
      "lbl" : "transversely striated visceral muscle cell",
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        "definition" : {
          "val" : "A visceral muscle that is transversely striated.  Examples include the visceral muscle cells of arthropods.",
          "xrefs" : [ "GOC:dos" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0008017",
      "lbl" : "adult skeletal muscle myoblast",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A skeletal muscle myoblast that is part of a skeletal mucle.  These cells are formed following acivation and division of skeletal muscle satellite cells. They form a transient population that is lost when they fuse to form skeletal muscle fibers.",
          "xrefs" : [ "PMID:23303905" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "myogenic precursor cell",
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      "id" : "http://purl.obolibrary.org/obo/CL_0008019",
      "lbl" : "mesenchymal cell",
      "type" : "CLASS",
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          "val" : "A non-polarised cell precursor cell that is part of some mesenchyme, is associated with the cell matrix but is not connected to other cells and is capable of migration."
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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      "id" : "http://purl.obolibrary.org/obo/CL_0008022",
      "lbl" : "endocardial cushion cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A mesenchymal cell of the endocardial cushion.   These cells develop via an epithelial to mesenchymal transition when endocardial cells break cell-to-cell contacts and migrate into the cardiac jelly. Cells from this population form the heart septa and valves.",
          "xrefs" : [ "PMID:18816864" ]
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      "lbl" : "pancreatic endocrine cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An endocrine cell that is part of the pancreas.",
          "xrefs" : [ "GOC:dos" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_0008025",
      "lbl" : "noradrenergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that release noradrenaline (noriphinephrine) as a neurotransmitter.",
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0008028",
      "lbl" : "visual system neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any neuron that is capable of part of some visual perception.",
          "xrefs" : [ "FBC:Autogenerated" ]
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      "lbl" : "cortical interneuron",
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        "definition" : {
          "val" : "An interneuron that has its soma located in the cerebral cortex."
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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      "id" : "http://purl.obolibrary.org/obo/CL_0008033",
      "lbl" : "decidual pericyte",
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        "definition" : {
          "val" : "A pericyte of the decidual vasculature.",
          "xrefs" : [ "PMID:30429548" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA" ],
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          "val" : "decidual perivascular cell"
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      "lbl" : "mural cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Mural cells are pericytes and the vascular smooth muscle cells (vSMCs) of the microcirculation.",
          "xrefs" : [ "Wiki:Mural_cell&oldid=930603194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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      "lbl" : "microcirculation associated smooth muscle cell",
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        "definition" : {
          "val" : "Any vascular associated smooth muscle cell that is part of some microcirculatory vessel.",
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        },
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      "lbl" : "mesothelial cell of intestine",
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      "id" : "http://purl.obolibrary.org/obo/CL_0008047",
      "lbl" : "intrafusal muscle fiber",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A skeletal muscle fiber that is part of a muscle spindle. These are specialized muscle fibers that serve as proprioceptors, detecting the amount and rate of change in length of a muscle. They are innervated by both sensory neurons and motor neurons (gamma and beta motorneurons, collectively referred to as fusimotor neurons).",
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          "val" : "A secretory epithelial cell of the respiratory tract epithelium.  These cells have an endodermal origin.",
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        },
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          "val" : "A neuron that releases both gamma-aminobutyric acid and glutamate as vesicular neurotransmitters.",
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        "definition" : {
          "val" : "Any cell in the retina, the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.",
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        },
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      "lbl" : "salivary gland cell",
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        "definition" : {
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        },
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      "lbl" : "enteroendocrine cell of small intestine",
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        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
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          "val" : "colon transit amplifying cell"
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          "val" : "transient amplifying cell of crypt of Lieberkuhn of colon"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009012",
      "lbl" : "transit amplifying cell of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rapidly proliferating population of cells that differentiate from stem cells of the intestinal crypt of the small intestine. Stem cells located in the crypts of Lieberkühn give rise to proliferating progenitor or transit amplifying cells that differentiate into the four major epithelial cell types. These include columnar absorptive cells or enterocytes, mucous secreting goblet cells, enteroendocrine cells and paneth cells.",
          "xrefs" : [ "PMID:20801415", "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "small intestine transit amplifying cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transient amplifying cell of crypt of Lieberkuhn of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transient amplifying cell of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transit amplifying cell of crypt of Lieberkuhn of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transit-amplifying cell of small intestine"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009014",
      "lbl" : "Peyer's patch lymphocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte that is part of a Peyer's patch. These cells have a major role in driving the immune response to antigens sampled from the intestinal lumen, and in regulating the formation of follicle-associated epithelium and M cells in Peyer's patches by converting intestitial enterocytes into M cells.",
          "xrefs" : [ "PMID:23525039", "PMID:9252325", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Peyer's patch resident lymphocyte"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "small intestine Peyer's patch lymphocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009016",
      "lbl" : "intestinal crypt stem cell of large intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intestinal stem cell that is located in the large intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the large intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.",
          "xrefs" : [ "PMID:20683682", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "crypt stem cell of large intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "stem cell of large intestine crypt of Lieberkuhn"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009017",
      "lbl" : "intestinal crypt stem cell of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intestinal stem cell that is located in the small intestine crypt of Liberkuhn. These stem cells reside at the bottom of crypts in the small intestine and are highly proliferative. They either differentiate into transit amplifying cells or self-renew to form new stem cells.",
          "xrefs" : [ "PMID:20683682", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "crypt stem cell of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "stem cell of small intestine crypt of Lieberkuhn"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009018",
      "lbl" : "lymphocyte of large intestine lamina propria",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte that resides in the lamina propria of the large intestine.",
          "xrefs" : [ "https://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lamina propria lymphocyte of large intestine"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009019",
      "lbl" : "nephrogenic zone cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A kidney cortical cell that is part of the nephrogenic zone.",
          "xrefs" : [ "PMID:29449449", "https://orcid.org/0000-0002-3163-0115" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cortical nephrogenic niche cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cortical nephrogenic zone cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009021",
      "lbl" : "stromal cell of lamina propria of large intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell found in the lamina propria of the large intestine.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009022",
      "lbl" : "stromal cell of lamina propria of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell found in the lamina propria of the small intestine.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009024",
      "lbl" : "mesothelial cell of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the small intestine.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009025",
      "lbl" : "mesothelial cell of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the colon.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "mesothelial cell of large intestine"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009037",
      "lbl" : "lymph node mantle zone B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B lymphocyte that resides in the mantle zone of the lymph node germinal center. These are generally IgM and IgD positive activated B cells that form a 'corona' around the germinal center and are part of the establishment of a secondary lymphatic follicule.",
          "xrefs" : [ "PMID:8011279", "http://orcid.org/0000-0003-4183-8865/", "https://www.arppress.org/v/vspfiles/assets/images/Chapter1T25LymphNodes.pdf" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "mantle zone B cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mantle zone B cell of lymph node"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009038",
      "lbl" : "colon macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A macrophage that is located in the colon.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "macrophage of colon"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009039",
      "lbl" : "colon goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is located in the colon.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of colon"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009040",
      "lbl" : "stromal cell of lamina propria of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell found in the lamina propria of the colon.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "stromal cell of colon lamina propria"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009041",
      "lbl" : "tuft cell of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the colonic epithelium, primarily adapted for microbial sensing in the dense colonic microbiota. Unlike its small intestinal counterpart, it does not participate in parasite-driven tuft cell–ILC2 circuits. Instead, it detects bacterial metabolites via taste-signaling pathways (Strine and Craig, 2022). The colonic tuft cell plays a key role in epithelial repair, modulates inflammatory responses through IL-25 secretion, and contributes to intestinal homeostasis by balancing microbiome interactions (Sebastian et al., 2021).",
          "xrefs" : [ "PMID:33079783", "PMID:35271673", "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "colon tuft cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009042",
      "lbl" : "enteroendocrine cell of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An enteroendocrine cell that is located in the colon.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "colon enteroendocrine cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009043",
      "lbl" : "intestinal crypt stem cell of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intestinal crypt stem cell that is located in the crypt of Lieberkuhn of colon.",
          "xrefs" : [ "PMID:10841502", "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009044",
      "lbl" : "lymphocyte of small intestine lamina propria",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lymphocyte that resides in the lamina propria of the small intestine. Lamina propria leukocytes and intraepithelial lymphocytes are the effector compartments of the gut mucosal immune system. Lymphocytes circulate through gut associated lymphoid tissues until recruitment by intestinal antigens. They are involved in the gut immune response.",
          "xrefs" : [ "PMID:26551552", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "gastrointestinal tract small intestine (lamina propria) leukocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "small intestine lamina propria leukocyte"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "small intestine lamina propria leukocyte (LPL)"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gastrointestinal tract (lamina propria) lymphocyte of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lamina propria lymphocyte of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "small intestine lamina propria lymphocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009045",
      "lbl" : "B cell of medullary sinus of lymph node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B cell found in the lymph node medullary sinus.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009046",
      "lbl" : "T cell of medullary sinus of lymph node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell found in the lymph node medullary sinus.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009047",
      "lbl" : "macrophage of medullary sinus of lymph node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A macrophage found in the medullary sinus of the lymph node.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "medullary sinus macrophage"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lymph node medullary sinus macrophage"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009048",
      "lbl" : "anorectum macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A macrophage that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "macrophage of anorectum"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009050",
      "lbl" : "B cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A B cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009051",
      "lbl" : "T cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009052",
      "lbl" : "smooth muscle cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anorectum smooth muscle cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009053",
      "lbl" : "stromal cell of anorectum lamina propria",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell found in the lamina propria of the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009056",
      "lbl" : "transit amplifying cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transit amplifying cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anorectum transit amplifying cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009057",
      "lbl" : "anorectum goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of anorectum"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009059",
      "lbl" : "plasma cell of medullary sinus of lymph node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A plasma cell that is located in the medullary sinus of the lymph node.",
          "xrefs" : [ "http://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "medullary plasma cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "medullary sinus plasma cell"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "plasma cell of medullary sinus"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009061",
      "lbl" : "intestinal crypt stem cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intestinal crypt stem cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anorectum intestinal crypt stem cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009063",
      "lbl" : "enteroendocrine cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An enteroendocrine cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anorectum enteroendocrine cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009065",
      "lbl" : "tuft cell of anorectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An intestinal tuft cell that is located in the anorectum.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anorectum tuft cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009066",
      "lbl" : "stratified squamous epithelial cell of anal canal",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stratified squamous epithelial cell that is part of the anal canal.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876" ]
        },
        "comments" : [ "This is a general grouping term created for use in the EMBL-EBI Single Cell Expression Atlas anatomograms. Please use a more specific cell type term for annotation if possible, given the information available to you." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anal canal stratified squamous epithelial cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009080",
      "lbl" : "tuft cell of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell located in the small intestine.",
          "xrefs" : [ "http://orcid.org/0000-0003-3440-1876", "http://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "brush cell of epithelium of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brush cell of epithelium proper of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "brush cell of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tuft cell of epithelium of small intestine"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009084",
      "lbl" : "glandular epithelial cell of endometrium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of an endometrium glandular epithelium.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "endometrial glandular epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of endometrial gland"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010710"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-11-30T16:13:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009086",
      "lbl" : "endothelial cell of respiratory system lymphatic vessel",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of a respiratory system lymphatic vessel.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "EFO:0010667"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-03T14:00:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009089",
      "lbl" : "lung pericyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pericyte cell that is part of a lung.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "comments" : [ "The marker set HIGD1B, KCNK3 can identify the Human cell type lung pericyte in the lung with a confidence of 0.84 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung pericyte cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pulmonary pericyte"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010669"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-03T17:13:33Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009091",
      "lbl" : "Leydig stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell found in the interstitial compartment of the neonatal testis; it is capable of self-renewal as well as differentiation into steroidogenic cells (adult Leydig cells). Intermediate stages of development include progenitor Leydig cells and immature Leydig cells.",
          "xrefs" : [ "PMID:21181888", "http://orcid.org/0000-0002-0819-0473" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "stem Leydig cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2022-02-18T14:09:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009092",
      "lbl" : "endothelial cell of placenta",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of a placenta.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "placental endothelial cell"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010708"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-13T13:53:01Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009093",
      "lbl" : "smooth muscle cell of placenta",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of a placenta.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "placental smooth muscle cell"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010709"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-13T13:56:42Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009094",
      "lbl" : "endothelial cell of hepatic portal vein",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of a hepatic portal vein.",
          "xrefs" : [ "PMID:30348985", "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "portal endothelial cell"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010704"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-13T14:01:05Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009095",
      "lbl" : "endothelial cell of uterus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of a uterus.",
          "xrefs" : [ "https://orcid.org/0000-0003-3440-1876", "https://orcid.org/0000-0003-4183-8865" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/pato#location_grouping" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "uterine endothelial cell"
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010711"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2021-12-13T14:39:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009097",
      "lbl" : "embryonic skeletal muscle fiber",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A skeletal muscle fiber found in an embryo. In mammalian embryos, skeletal muscle expresses myosin heavy chain-embryonic (MyHC-emb, encoded by the MYH3 gene), which regulates skeletal muscle development.",
          "xrefs" : [ "PMID:32094117", "PMID:7196501", "http://orcid.org/0000-0003-2034-601X" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2022-02-21T15:39:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009100",
      "lbl" : "hepatic portal fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast located in the portal triad. Hepatic portal fibroblast are a non-parenchymal cell population located adjacent to bile duct epithelia in liver and are distinct from stellate cells. They differentiate into fibrogenic myofibroblasts during chronic injury states producing high levels of collagen.",
          "xrefs" : [ "PMID:20209607", "PMID:24814904", "https://orcid.org/0000-0001-7655-4833" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "portal fibroblast"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2022-03-17T12:00:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009115",
      "lbl" : "lymph node lymphatic vessel endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell located in a lymph node lymphatic vessel.",
          "xrefs" : [ "https://orcid.org/0000-0001-7655-4833" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0009116",
      "lbl" : "progenitor cell of mammary luminal epithelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A progenitor cell with the potential to differentiate into luminal epithelial cells of mammary glands. In mouse, CD61 and c-kit were found to be coexpressed by the majority of, but not all, committed luminal progenitor cells.",
          "xrefs" : [ "PMID:19063729", "PMID:20346151", "PMID:21930782", "https://orcid.org/0000-0003-4412-7970" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "luminal progenitor cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor cell of luminal mammary epithelium"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-2825-0621"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010001",
      "lbl" : "stromal cell of bone marrow",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell that is part_of a bone marrow."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "bone marrow stromal cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-6601-2165"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010002",
      "lbl" : "epithelial cell of umbilical artery",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part_of a umbilical artery."
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "umbilical artery epithelial cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-6601-2165"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010004",
      "lbl" : "mononuclear cell of bone marrow",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mononuclear cell that is part_of a bone marrow."
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "bone marrow mononuclear cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-6601-2165"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010005",
      "lbl" : "atrioventricular bundle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized cardiomyocyte that transmit signals from the AV node to the cardiac Purkinje fibers.",
          "xrefs" : [ "GOC:mtg_heart" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "AV bundle cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010006",
      "lbl" : "cardiac blood vessel endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any blood vessel endothelial cell that is part of some heart.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010007",
      "lbl" : "His-Purkinje system cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some His-Purkinje system.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010008",
      "lbl" : "cardiac endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some heart.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010009",
      "lbl" : "camera-type eye photoreceptor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any photoreceptor cell that is part of some camera-type eye.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "camera type eye photoreceptor cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010010",
      "lbl" : "cerebellar stellate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell receives excitatory inputs primarily from parallel fibers and plays a crucial role in feed-forward inhibition by suppressing the activity of Purkinje cells and modulating the output of the cerebellar cortex. The stellate cell is part of the local circuitry that contributes to the fine-tuning of motor coordination and a regulator of cerebellar blood flow via neurovascular coupling.",
          "xrefs" : [ "PMID:31110133", "PMID:5042759" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010011",
      "lbl" : "cerebral cortex GABAergic interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A GABAergic interneuron whose soma is located in the cerebral cortex.",
          "xrefs" : [ "GOC:dos" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010012",
      "lbl" : "cerebral cortex neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CNS neuron of the cerebral cortex.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cortical neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neuron of cerebral cortex"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004102"
        }, {
          "val" : "FMA:84104"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-7258-9596"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010017",
      "lbl" : "zygote",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A zygote in a plant or an animal."
        },
        "xrefs" : [ {
          "val" : "MESH:D015053"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010020",
      "lbl" : "cardiac glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any glial cell that is part of some heart.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010021",
      "lbl" : "cardiac myoblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any myoblast that develops into some cardiac muscle cell.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "MESH:D032386"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0010022",
      "lbl" : "cardiac neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that has its soma in the heart.",
          "xrefs" : [ "PMID:12486170", "PMID:29265764" ]
        },
        "comments" : [ "This term is used in 3 GO terms that were created as part of the heart development focus project." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011000",
      "lbl" : "dorsal horn interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CNS interneuron located in the dorsal horn of the spinal cord.",
          "xrefs" : [ "GOC:nv" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "dorsal spinal cord interneuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011001",
      "lbl" : "spinal cord motor neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.",
          "xrefs" : [ "GOC:nv" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011003",
      "lbl" : "magnocellular neurosecretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neurosecretory neuron residing mainly in the hypothalamic supraoptic and paraventricular nuclei and in a number of smaller accessory cell groups between these two nuclei, that is capable of secreting the hormones oxytocin or vasopressin, and sometimes both, into the systemic circulation.",
          "xrefs" : [ "GOC:nv", "MP:0009467", "PMID:10711808" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "magnocellular neuron"
        } ],
        "xrefs" : [ {
          "val" : "ILX:0107463"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-7258-9596"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011004",
      "lbl" : "lens fiber cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A vetebrate lens cell that is any of the elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye.",
          "xrefs" : [ "GO:0070307", "GOC:nv" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lens fibre cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011005",
      "lbl" : "GABAergic interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An interneuron that uses GABA as a vesicular neurotransmitter.  These interneurons are inhibitory",
          "xrefs" : [ "GOC:CellBLAST", "GOC:nv", "PMID:29724907" ]
        },
        "comments" : [ "The formal and textual definitions of this term will need to be altered if evidence for non-inhibitory GABA-ergic neurons emerges." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GABAergic inhibitory interneuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011007",
      "lbl" : "paraxial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell in the area of mesoderm in the neurulating embryo that flanks and forms simultaneously with the neural tube. The cells of this region give rise to somites.",
          "xrefs" : [ "GOC:NV", "PMID:11687492" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "paraxial mesoderm cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "somitic mesoderm cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "presomitic mesoderm cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011012",
      "lbl" : "neural crest cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell of the neural crest. Neural crest cells are multipotent. Premigratory neural crest cells are found at the neural plate boarder, some of which will undergo ectomesynchymal transition and delamination to form migratory neural crest cells.",
          "xrefs" : [ "https://orcid.org/0000-0001-5208-3432", "https://orcid.org/0000-0002-9900-7880" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011013",
      "lbl" : "motile sperm cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A sperm cell that is cabaple of motion (motility).",
          "xrefs" : [ "PMID:30612620" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011016",
      "lbl" : "flagellated sperm cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A motile sperm cell that contains a slender threadlike microscopic appendage that enables motion.",
          "xrefs" : [ "PMID:30612620", "https://www.lexico.com/en/definition/flagellum" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011019",
      "lbl" : "mesothelial cell of epicardium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the epicardium."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011021",
      "lbl" : "fibroblast of upper back skin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of upper back skin."
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011022",
      "lbl" : "fibroblast of skin of back",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of skin of back."
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011025",
      "lbl" : "exhausted T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An effector T cell that displays impaired effector functions (e.g., rapid production of effector cytokines, cytotoxicity) and has limited proliferative potential.",
          "xrefs" : [ "PMID:26544946" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Tex cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011026",
      "lbl" : "progenitor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A precursor cell that has a tendency to differentiate into a specific type of cell. They are descendants of stem cells, only they are more constrained in their differentiation potential or capacity for self-renewal, and are often more limited in both senses.",
          "xrefs" : [ "ISBN:978-1-62808-994-3", "https://doi.org/10.1016/B978-0-12-409503-8.00002-0" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011027",
      "lbl" : "skeletal muscle fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any fibroblast that is part of skeletal muscle tissue.",
          "xrefs" : [ "PMID:28369879", "https://orcid.org/0000-0001-6164-0667" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "skeleton muscle fibroblast"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011030",
      "lbl" : "dermal microvascular endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any microvascular endothelial cell that is part of the dermis.",
          "xrefs" : [ "BTO:0004574", "CL:patterns/cellPartOfAnatomicalEntity" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DMEC cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "dermal microvascular endothelium cell"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-5208-3432"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011101",
      "lbl" : "chorionic trophoblast cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cells of the uterine chorion that acquire specialized structural and/or functional features that characterize chorionic trophoblasts. These cells will migrate towards the spongiotrophoblast layer and give rise to syncytiotrophoblasts of the labyrinthine layer.",
          "xrefs" : [ "GOC:NV" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011108",
      "lbl" : "colon epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Epithelial cell that is part of the colon epithelium.",
          "xrefs" : [ "GOC:NV" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "colonic epithelial cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011111",
      "lbl" : "hypothalamic gonadotropin-releasing hormone neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "a specialized neuroendocrine cell that synthesizes and secretes GnRH decapeptide, a key regulator of reproductive function. It originates from the olfactory placode during embryonic development and migrates into the forebrain where it localises predominantly in the hypothalamus and in humans, in extrahypothalamic regions like the basal ganglia (Skrapits et al., 2021). This cell regulates reproduction by secreting GnRH into the pituitary portal vessels to induce the release of gonadotropins into the general circulation. It expresses receptor subunits required for AMPA, NMDA, and kainate receptor signaling and may use glutamate as a neurotransmitter in recurrent collateral innervation.",
          "xrefs" : [ "GOC:NV", "PMID:20807514", "PMID:21828096", "PMID:26053743", "PMID:34128468", "PMID:35067985" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GnRH neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GnRH-secreting neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011113",
      "lbl" : "spiral ganglion neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Neuron found in the spiral ganglion.",
          "xrefs" : [ "GOC:NV" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0011115",
      "lbl" : "precursor cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that, by division or terminal differentiation, can give rise to other cell types.",
          "xrefs" : [ "GOC:dos" ]
        },
        "comments" : [ "Work is needed on GO 'cell differentiation' before it is clear whether the equivalent class definition 'native cell' that capable_of some 'cell differentiation' works. Also, may want to consider merging this with non-terminally differentiated cell." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0012000",
      "lbl" : "astrocyte of the forebrain",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An astrocyte of the forebrain."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "forebrain astrocyte"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-3837-8864"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0012001",
      "lbl" : "neuron of the forebrain",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CNS neuron of the forebrain."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "forebrain neuron"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-3837-8864"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0013000",
      "lbl" : "forebrain radial glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any radial glial cell that is part of some forebrain.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017000",
      "lbl" : "pulmonary ionocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An ionocyte that is part of the lung epithelium. The cells from this type are major sources of the CFTR protein in human and mice.",
          "xrefs" : [ "PMID:30069044", "PMID:30069046" ]
        },
        "comments" : [ "The marker set ASCL3, BSND can identify the Human cell type pulmonary ionocyte in the lung with a confidence of 0.82 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0003-2473-2313"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017002",
      "lbl" : "prostate neuroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroendocrine cell that is part of the prostate epithelium.",
          "xrefs" : [ "PMID:33842835", "http://orcid.org/0000-0001-7772-9578" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuroendocrine cell of prostate epithelium"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neuroendocrine cell of the prostate"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "http://orcid.org/0000-0003-2473-2313"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017003",
      "lbl" : "epithelial cell of prostatic urethra",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the prostatic urethra.",
          "xrefs" : [ "PMID:30566875" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "http://orcid.org/0000-0003-2473-2313"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017500",
      "lbl" : "neutrophillic cytoplasm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cytoplasm that exhibits a characteristic staining and color, pale-pink, with Wright-Giemsa stain.",
          "xrefs" : [ "GOC:add" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2010-05-25T01:36:34Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017502",
      "lbl" : "acidophilic cytoplasm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cytoplasm that exhibits a characteristic staining and color, red or pink, with Eosin stain.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "eosinophilic"
        } ],
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          "val" : "2009-12-22T04:23:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017503",
      "lbl" : "basophilic cytoplasm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cytoplasm that exhibits molecular interaction for basic dyes under specific pH conditions.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-22T04:24:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017504",
      "lbl" : "polychromatophilic cytoplasm",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Cytoplasm that exhibits affinity for both basic and acid stains under specific pH conditions.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-28T04:25:23Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0017508",
      "lbl" : "cartwheel heterochromatin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Heterochromatin that is arranged in a carthwheel pattern.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-28T04:28:35Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019001",
      "lbl" : "tracheobronchial serous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any serous secreting cell that is part of the tracheobronchial epithelium."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA", "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "serous cell of tracheobronchial tree"
        } ],
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          "val" : "2020-05-07T16:03:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019002",
      "lbl" : "tracheobronchial chondrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any chondrocyte that is part of the tracheobronchial tree."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chondrocyte of tracheobronchial tree"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2020-05-07T17:29:51Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019003",
      "lbl" : "tracheobronchial goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any goblet cell that is part of the tracheobronchial epithelium."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#added_for_HCA", "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of tracheobronchial tree"
        } ],
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2020-05-07T18:14:52Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019017",
      "lbl" : "lymphatic vessel smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of any lymphatic vessel.",
          "xrefs" : [ "PMID:15109561" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle cell of lymphatic vessel"
        } ],
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        }, {
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          "val" : "2020-07-21T12:29:51Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019018",
      "lbl" : "blood vessel smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of any blood vessel.",
          "xrefs" : [ "PMID:9108778" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle cell of blood vessel"
        } ],
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2020-07-21T12:42:48Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019019",
      "lbl" : "tracheobronchial smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the tracheobronchial tree.",
          "xrefs" : [ "PMID:10853867" ]
        },
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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          "val" : "smooth muscle cell of tracheobronchial tree"
        } ],
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        }, {
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          "val" : "2020-07-21T12:50:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019020",
      "lbl" : "extrahepatic cholangiocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the extrahepatic bile ducts, including the left and right hepatic duct, common hepatic duct, and common bile duct. They are columnar in shape, and have a large nuclear-to-cytoplasmic ratio relative to small/intrahepatic cholangiocytes.",
          "xrefs" : [ "PMID:23720296" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "large bile duct cholangiocyte",
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        } ],
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          "val" : "2020-09-03T12:24:24Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019021",
      "lbl" : "endothelial cell of periportal hepatic sinusoid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell found in the periportal region hepatic sinusoid, near the portal triad. The fenestrae of these cells are larger but fewer in number compared with those of endothelial cells near the centrilobular region of the hepatic sinusoid.",
          "xrefs" : [ "PMID:27423426" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "pred" : "hasExactSynonym",
          "val" : "periportal LSEC",
          "xrefs" : [ "PMID:28287163" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "periportal hepatic sinusoidal endothelial cell",
          "xrefs" : [ "PMID:30348985" ]
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010705"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2020-09-09T13:56:47Z"
        } ]
      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0019022",
      "lbl" : "endothelial cell of pericentral hepatic sinusoid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell found in the centrilobular region hepatic sinusoid, near the central vein. The fenestrae of these cells are smaller but more numerous compared with those of endothelial cells near the periportal region of the hepatic sinusoid.",
          "xrefs" : [ "PMID:27423426" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "central venous hepatic sinusoidal endothelial cell",
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          "pred" : "hasExactSynonym",
          "val" : "pericentral LSEC",
          "xrefs" : [ "PMID:28287163" ]
        } ],
        "xrefs" : [ {
          "val" : "EFO:0010706"
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          "val" : "2020-09-10T12:38:29Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019031",
      "lbl" : "intestine goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3.",
          "xrefs" : [ "PMID:1996606", "PMID:24942678", "PMID:33484640" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intestinal goblet cell",
          "xrefs" : [ "PMID:1996606" ]
        } ],
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          "val" : "2020-10-14T14:59:07Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0019032",
      "lbl" : "intestinal tuft cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the intestinal epithelium, characterized by a distinctive apical tuft and lateral cytospinules connecting to neighbouring cells. This cell senses luminal stimuli via taste receptors and succinate signalling, initiating type 2 immune responses through the secretion of interleukin-25 while modulating epithelial regeneration through prostaglandin synthesis. It expresses key molecular markers such as doublecortin-like kinase 1 (DCLK1) in mice (Hendel et al., 2022), and KIT proto-oncogene in humans (Huang et al., 2024). Developed from intestinal crypt stem cells, this cell requires transcription factor POU2F3 for its development.",
          "xrefs" : [ "PMID:22527717", "PMID:29714721", "PMID:35237268", "PMID:39358509" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "intestinal brush cell",
          "xrefs" : [ "PMID:22527717" ]
        } ],
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          "val" : "2020-10-15T12:47:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0020005",
      "lbl" : "spiral ligament fibrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An otic fibrocyte that is part of the spiral ligament. This cell is crucial in maintaining the endocochlear potential, regulating blood flow, participating in immune responses by secreting chemokines including MCP-1 and MIP-2, and producing extracellular matrix proteins such as collagen and cochlin.",
          "xrefs" : [ "PMID:10675641", "PMID:33193034" ]
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          "val" : "2025-10-27T15:56:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0020011",
      "lbl" : "hair follicle associated fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized dermal fibroblast within the hair follicle mesenchymal compartment that participates in epithelial-mesenchymal signaling to regulate hair morphogenesis, cycling, and homeostasis through production of inductive signals and extracellular matrix maintenance.",
          "xrefs" : [ "PMID:20022473", "PMID:34297930" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2025-11-04T15:29:55Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_0020012",
      "lbl" : "hair follicle isthmus-associated fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the hair follicle isthmus (mid-hair shaft). In humans, this cell expresses CRABP1/COCH/RSPO4 and tendon-associated genes (MKX, TNMD).",
          "xrefs" : [ "PMID:40993240" ]
        },
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      "id" : "http://purl.obolibrary.org/obo/CL_0020029",
      "lbl" : "cuboidal epithelial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An epithelial cell that has a cuboidal morphology."
        },
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0006-9765-6788"
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          "val" : "2025-12-16T15:56:39Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_0020030",
      "lbl" : "CD4-positive exhausted alpha-beta T cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A CD4-positive alpha-beta T cell that displays impaired function and altered differentiation as a result of chronic antigenic stimulation (e.g., chronic infection, tumors, or persistent inflammation). This state is characterised by sustained expression of PD-1 as a shared feature. Additional exhaustion-associated molecules, including the transcription factor TOX, and context- or stage-dependent changes in markers such as LAG-3, TIM-3, CD39, and T-bet, may also be observed; however, the expression levels of these molecules vary depending on exhaustion stage and tissue environment.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "CD4+ exhausted T lymphocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "exhausted CD4 T cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "exhausted CD4-positive T cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://github.com/obophenotype/cell-ontology/issues/3453"
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          "val" : "https://orcid.org/0000-0001-5742-4697"
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2026-01-13T15:30:05Z"
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_0020035",
      "lbl" : "intestinal intraepithelial lymphocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A T cell that is located in the intestinal epithelium and is capable of a mucosal immune response.",
          "xrefs" : [ "PMID:29674648", "WIKIPEDIA:Intraepithelial_lymphocyte" ]
        },
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          "val" : "2026-01-05T11:44:26Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000001",
      "lbl" : "retrotrapezoid nucleus neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that has its soma located in some retrotrapezoid nucleus.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000022",
      "lbl" : "mesonephric nephron tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of some mesonephric nephron tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000042",
      "lbl" : "forebrain neuroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuroblast (sensu Vertebrata) that is part of some forebrain.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000050",
      "lbl" : "lateral line nerve glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any glial cell that is part of some lateral line nerve.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000073",
      "lbl" : "spinal cord radial glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any radial glial cell that is part of some spinal cord.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000082",
      "lbl" : "stretch receptor cell",
      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000090",
      "lbl" : "pronephric nephron tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of some pronephric nephron tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000123",
      "lbl" : "metanephric nephron tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of some metanephric nephron tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000143",
      "lbl" : "lung goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any goblet cell that is part of some lung epithelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000147",
      "lbl" : "cardiac valve cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a cardiac valve.",
          "xrefs" : [ "PMID:25311230" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "heart valve cell",
          "xrefs" : [ "PMID:30796046" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000191",
      "lbl" : "pillar cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A rod-like cell in the inner ear, having their heads joined and their bases on the basilar membrane widely separated so as to form a spiral tunnel known as the tunnel of Corti.",
          "xrefs" : [ "GOC:tfm", "PMID:12417662" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pillar cell of cochlea"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pillar cell of corti"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "rod cell of Corti"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cochlear pillar cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:75722"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000222",
      "lbl" : "stomach neuroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialised neuroendocrine cell located in the gastric mucosa that regulates digestive processes including acid secretion and gut motility. This cell stores hormones in large dense core vesicles and synaptic-like microvesicles.",
          "xrefs" : [ "PMID:15153415" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "DES cell",
          "xrefs" : [ "PMID:15153415" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "diffuse endocrine system cell",
          "xrefs" : [ "PMID:15153415" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000223",
      "lbl" : "pulmonary neuroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuroendocrine cell that is part of respiratory epithelium of the lung and is involved in the sensory detection of environmental stimuli, including hypoxia, nicotine and air pressure. Ultrastructurally, this cell type is characterized by the presence of cytoplasmic dense core granules, which are considered the storage sites of amine and peptide hormones. Pulmonary neuroendocrine cells are innervated and appear as solitary cells or as clustered masses, localized at airway bifurcation sites, called neuroepithelial bodies that can release serotonin in response to hypoxia and interact with sensory nerve terminals. Pulmonary neuroendocrine cells also function as reserve stem cells that repair the surrounding epithelium after injury.",
          "xrefs" : [ "PMID:33355253", "doi:10.3109/01902148209069653", "doi:10.7554/eLife.78216" ]
        },
        "comments" : [ "The marker set CHGA, GRP can identify the Human cell type pulmonary neuroendocrine cell in the lung with a confidence of 0.94 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung neuroendocrine cell",
          "xrefs" : [ "PMID:15018448" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000271",
      "lbl" : "lung multiciliated epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the lung epithelium. This cell is characterised by the presence of cilia on its apical surface.",
          "xrefs" : [ "PMID:27864314" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung ciliated cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000272",
      "lbl" : "lung secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any secretory cell that is part of some lung.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000274",
      "lbl" : "trophectodermal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An extraembryonic cell that is part of the trophectoderm, representing the first lineage to differentiate in the embryo. This cell is crucial for implantation into the uterine wall and differentiates into trophoblast cells, which contribute to placenta formation and facilitate maternal-fetal nutrient and signal exchange.",
          "xrefs" : [ "PMID:22918806" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "trophectoderm cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000275",
      "lbl" : "smooth muscle cell of small intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the small intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of small intestine",
          "xrefs" : [ "FMA:15050" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15050"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000276",
      "lbl" : "smooth muscle fiber of duodenum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the duodenum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of duodenum",
          "xrefs" : [ "FMA:15058" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15058"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000277",
      "lbl" : "smooth muscle fiber of jejunum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the jejunum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of jejunum",
          "xrefs" : [ "FMA:15062" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15062"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000278",
      "lbl" : "smooth muscle fiber of ileum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the ileum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of ileum",
          "xrefs" : [ "FMA:15066" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15066"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000279",
      "lbl" : "smooth muscle cell of large intestine",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the large intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of large intestine",
          "xrefs" : [ "FMA:15653" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15653"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000280",
      "lbl" : "smooth muscle cell of colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the colon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of colon",
          "xrefs" : [ "FMA:15663" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:15663"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000281",
      "lbl" : "smooth muscle cell of cecum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the cecum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of cecum",
          "xrefs" : [ "FMA:15681" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle fiber of cecum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:15681"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000282",
      "lbl" : "smooth muscle fiber of ascending colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the ascending colon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of ascending colon",
          "xrefs" : [ "FMA:17518" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:17518"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000283",
      "lbl" : "smooth muscle fiber of transverse colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the transverse colon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of transverse colon",
          "xrefs" : [ "FMA:17519" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:17519"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000284",
      "lbl" : "smooth muscle fiber of descending colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the descending colon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of descending colon",
          "xrefs" : [ "FMA:17520" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:17520"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000285",
      "lbl" : "smooth muscle cell of sigmoid colon",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the sigmoid colon.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of sigmoid colon",
          "xrefs" : [ "FMA:17521" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:17521"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000286",
      "lbl" : "smooth muscle cell of rectum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the rectum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "non-striated muscle fiber of rectum",
          "xrefs" : [ "FMA:17522" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle fiber of rectum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:17522"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000296",
      "lbl" : "epithelial cell of urethra",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the urethra.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:256165"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000298",
      "lbl" : "mesothelial cell of dura mater",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the dura mater.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "squamous mesothelial cell of dura mater",
          "xrefs" : [ "FMA:256516" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:256516"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000302",
      "lbl" : "fibroblast of papillary layer of dermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the papillary layer of dermis.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:261277"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000303",
      "lbl" : "fibroblast of areolar connective tissue",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the areolar connective tissue.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:261279"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000306",
      "lbl" : "fibroblast of tunica adventitia of artery",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the tunica adventitia of artery.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:261285"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000307",
      "lbl" : "fibroblast of dense regular elastic tissue",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the dense regular elastic tissue.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:261287"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000309",
      "lbl" : "epicardial adipocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of the epicardial fat.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adipocyte of epicardial fat",
          "xrefs" : [ "FMA:261293" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epicardial fat cell",
          "xrefs" : [ "FMA:261293" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:261293"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000310",
      "lbl" : "adipocyte of epicardial fat of right ventricle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of the epicardial fat of right ventricle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epicardial adipocyte of right ventricle",
          "xrefs" : [ "FMA:261297" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epicardial fat cell of right ventricle",
          "xrefs" : [ "FMA:261297" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:261297"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000311",
      "lbl" : "adipocyte of epicardial fat of left ventricle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An adipocyte that is part of the epicardial fat of left ventricle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epicardial adipocyte of left ventricle",
          "xrefs" : [ "FMA:261300" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epicardial fat cell of left ventricle",
          "xrefs" : [ "FMA:261300" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:261300"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000312",
      "lbl" : "bronchial goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of bronchus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "The marker set PLCG2, ANKRD36C can identify the Human cell type bronchial goblet cell in the lung with a confidence of 0.55 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of bronchus",
          "xrefs" : [ "FMA:263032" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:263032"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000313",
      "lbl" : "gastric goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of stomach.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of stomach",
          "xrefs" : [ "FMA:263035" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:263035"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000314",
      "lbl" : "gastric cardiac gland goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of gastric cardiac gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of gastric cardiac gland"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263038"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000317",
      "lbl" : "intestinal villus goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of intestinal villus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of intestinal villus"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263046"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000320",
      "lbl" : "large intestine goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of large intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of large intestine"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263054"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000321",
      "lbl" : "large intestine crypt goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of crypt of Lieberkuhn of large intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263056"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000322",
      "lbl" : "pancreatic goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of pancreatic duct.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of pancreatic duct",
          "xrefs" : [ "FMA:263058" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:263058"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000323",
      "lbl" : "pyloric gastric gland goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of pyloric gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of pyloric gland"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263061"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000324",
      "lbl" : "duodenal goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium proper of duodenum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium proper of duodenum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263063"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000325",
      "lbl" : "jejunal goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium proper of jejunum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium proper of jejunum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263065"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000326",
      "lbl" : "ileal goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium proper of ileum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium proper of ileum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263067"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000329",
      "lbl" : "tracheal goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the epithelium of trachea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of trachea",
          "xrefs" : [ "FMA:263075" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:263075"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000330",
      "lbl" : "serous cell of epithelium of trachea",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A serous secreting cell that is part of the epithelium of trachea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263078"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000331",
      "lbl" : "serous cell of epithelium of bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A serous secreting cell that is part of the epithelium of bronchus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263080"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000332",
      "lbl" : "serous cell of epithelium of terminal bronchiole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A serous secreting cell that is part of the epithelium of terminal bronchiole.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263082"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000348",
      "lbl" : "basal cell of epithelium of trachea",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell that is part of the epithelium of trachea.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263118"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000349",
      "lbl" : "basal cell of epithelium of bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell found in the bronchus epithelium.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basal cell of bronchus"
        } ],
        "xrefs" : [ {
          "val" : "FMA:263120"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000350",
      "lbl" : "basal cell of epithelium of terminal bronchiole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell that is part of the epithelium of terminal bronchiole.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263122"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000351",
      "lbl" : "basal cell of epithelium of respiratory bronchiole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell that is part of the epithelium of respiratory bronchiole.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:263124"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000361",
      "lbl" : "transitional myocyte of interatrial septum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the interatrial septum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263152"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000362",
      "lbl" : "transitional myocyte of interventricular septum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the interventricular septum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263154"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000370",
      "lbl" : "transitional myocyte of left branch of atrioventricular bundle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the left branch of atrioventricular bundle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263170"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000371",
      "lbl" : "transitional myocyte of right branch of atrioventricular bundle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the right branch of atrioventricular bundle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263172"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000376",
      "lbl" : "Purkinje myocyte of interventricular septum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Purkinje myocyte that is part of the interventricular septum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263182"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000379",
      "lbl" : "type 1 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type I vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263188"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000380",
      "lbl" : "type 1 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type I vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263190"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000381",
      "lbl" : "type 1 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type I vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263192"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000383",
      "lbl" : "type 2 vestibular sensory cell of epithelium of macula of utricle of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type II vestibular sensory cell that is part of the epithelium of macula of utricle of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263196"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000384",
      "lbl" : "type 2 vestibular sensory cell of epithelium of macula of saccule of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type II vestibular sensory cell that is part of the epithelium of macula of saccule of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263198"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000385",
      "lbl" : "type 2 vestibular sensory cell of epithelium of crista of ampulla of semicircular duct of membranous labyrinth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type II vestibular sensory cell that is part of the epithelium of crista of ampulla of semicircular duct of membranous labyrinth.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:263200"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000391",
      "lbl" : "melanocyte of eyelid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte that is part of the eyelid.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "eyelid melanocyte",
          "xrefs" : [ "FMA:59175" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sebaceous gland of wolff",
          "xrefs" : [ "FMA:59175" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:59175"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000398",
      "lbl" : "endothelial cell of hepatic sinusoid",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the hepatic sinusoid. These cells possess flattened areas containing perforations about 0.1 micrometers in diameter, known as fenestrae. The fenestrae are arranged in groups known as sieve plates.",
          "xrefs" : [ "GOC:tfm", "PMID:3926620" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "LSEC",
          "xrefs" : [ "PMID:30348985" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "endotheliocyte of hepatic sinusoid",
          "xrefs" : [ "FMA:62911" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver sinusoidal endothelial cell",
          "xrefs" : [ "PMID:30348985" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:000125"
        }, {
          "val" : "FMA:62911"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000409",
      "lbl" : "myocyte of sinoatrial node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A muscle cell that is part of the sinoatrial node.",
          "xrefs" : [ "FMA:67102", "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "SA nodal myocyte",
          "xrefs" : [ "FMA:67102" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SA node cardiac muscle cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sinoatrial node cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sinoatrial node myocyte"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sinuatrial node myocyte",
          "xrefs" : [ "FMA:67102" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:67102"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000410",
      "lbl" : "myocyte of atrioventricular node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A muscle cell that is part of the atrioventricular node.",
          "xrefs" : [ "FMA:67106", "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "AV nodal myocyte",
          "xrefs" : [ "FMA:67106" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "AV node cardiac muscle cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "AV node cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "atrioventricular node cell",
          "xrefs" : [ "GOC:pr" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "atrioventricular node myocyte",
          "xrefs" : [ "FMA:67106" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:67106"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000411",
      "lbl" : "endothelial cell of Peyer's patch",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the small intestine Peyer's patch.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67757"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000412",
      "lbl" : "endothelial cell of arteriole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the arteriole.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:67760"
        }, {
          "val" : "KUPO:0001097"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000413",
      "lbl" : "endothelial cell of artery",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A blood vessel endothelial cell that is part of an arterial endothelium.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "arterial endothelial cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004758"
        }, {
          "val" : "FMA:67761"
        }, {
          "val" : "KUPO:0001095"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000414",
      "lbl" : "endothelial cell of venule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the venule.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:67762"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000415",
      "lbl" : "epithelial cell of gallbladder",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the gallbladder.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67780"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000417",
      "lbl" : "myoepithelial cell of sweat gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoepithelial cell that is part of the sweat gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:67801"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000418",
      "lbl" : "myoepithelial cell of lactiferous alveolus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoepithelial cell that is part of the mammary gland alveolus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basal cell of alveolus of lactiferous gland",
          "xrefs" : [ "FMA:67802" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "myoepithelial cell of mammary alveolus",
          "xrefs" : [ "FMA:67802" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:67802"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000419",
      "lbl" : "myoepithelial cell of lactiferous duct",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoepithelial cell that is part of the lactiferous duct.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:67803"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000424",
      "lbl" : "chromaffin cell of paraaortic body",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the paraaortic body.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chromaffin cell of para-aortic body",
          "xrefs" : [ "FMA:69328" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:69328"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000425",
      "lbl" : "chromaffin cell of paraganglion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the paraganglion.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:69335"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000426",
      "lbl" : "chromaffin cell of adrenal gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the adrenal gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adrenal chromaffin cell",
          "xrefs" : [ "GO:0061104" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:69794"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000427",
      "lbl" : "adrenal cortex chromaffin cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the adrenal cortex.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "Not clear this cell type exists. Can't call it a cortical adrenal cell because of different germ layer origin." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chromaffin cell of adrenal cortex"
        } ],
        "xrefs" : [ {
          "val" : "FMA:69795"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000428",
      "lbl" : "stem cell of epidermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A somatic stem cell that is part of the epidermis.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epidermal stem cell",
          "xrefs" : [ "FMA:70541" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70541"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000432",
      "lbl" : "conjunctival epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the conjunctiva.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of conjunctiva",
          "xrefs" : [ "FMA:70552" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70552"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000434",
      "lbl" : "epithelial cell of external acoustic meatus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the external acoustic meatus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70555"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000435",
      "lbl" : "epithelial cell of lacrimal drainage system",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the lacrimal drainage system.",
          "xrefs" : [ "GOC:tfm", "PMID:22594785" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "epithelial cell of lacrimal duct"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70559"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000436",
      "lbl" : "epithelial cell of lacrimal sac",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the lacrimal sac.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70560"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000437",
      "lbl" : "epithelial cell of nasolacrimal duct",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the nasolacrimal duct.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70561"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000442",
      "lbl" : "urothelial cell of trigone of urinary bladder",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An urothelial cell that is part of the trigone of urinary bladder.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of vesical trigone",
          "xrefs" : [ "FMA:70598" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70598"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000443",
      "lbl" : "ciliary muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the ciliary body.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle cell of ciliary body",
          "xrefs" : [ "FMA:70610" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70610"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000444",
      "lbl" : "mesothelial cell of anterior chamber of eye",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the anterior chamber of eyeball.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70615"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000445",
      "lbl" : "myoepithelial cell of dilator pupillae",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoepithelial cell that is part of the dilatator pupillae.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70619"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000447",
      "lbl" : "epithelial cell of stratum germinativum of esophagus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell that is part of the epithelium of esophagus.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "basal cell of esophageal epithelium",
          "xrefs" : [ "FMA:70731" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70731"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000448",
      "lbl" : "epithelial cell of sweat gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the sweat gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:70952"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000449",
      "lbl" : "epithelial cell of nephron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the nephron.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:70965"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000450",
      "lbl" : "epithelial cell of glomerular capsule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the glomerular capsule.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Bowmans capsule epithelial cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of Bowman's capsule",
          "xrefs" : [ "FMA:70966" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70966"
        }, {
          "val" : "KUPO:0001034"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000452",
      "lbl" : "parietal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the glomerular parietal epithelium.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of parietal layer of glomerular capsule",
          "xrefs" : [ "FMA:70968" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70968"
        }, {
          "val" : "KUPO:0001035"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000453",
      "lbl" : "epithelial cell of intermediate tubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the intermediate tubule.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:70980"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000454",
      "lbl" : "kidney collecting duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the collecting duct of renal tubule.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of renal collecting tubule",
          "xrefs" : [ "FMA:70982" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:70982"
        }, {
          "val" : "KUPO:0001059"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000456",
      "lbl" : "mesothelial cell of parietal peritoneum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the parietal peritoneum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:72142"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000457",
      "lbl" : "mesothelial cell of visceral peritoneum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the visceral peritoneum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:72143"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000458",
      "lbl" : "melanocyte of skin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A melanocyte that is part of the skin of body.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "skin melanocyte",
          "xrefs" : [ "FMA:72144" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2374"
        }, {
          "val" : "FMA:72144"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000465",
      "lbl" : "chromaffin cell of ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the ovary.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:74319"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000466",
      "lbl" : "chromaffin cell of right ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the right ovary.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:74320"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000467",
      "lbl" : "chromaffin cell of left ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromaffin cell that is part of the left ovary.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:74321"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000478",
      "lbl" : "transitional myocyte of sinoatrial node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the sinoatrial node.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transitinal myocyte of sinuatrial node"
        } ],
        "xrefs" : [ {
          "val" : "FMA:83384"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000479",
      "lbl" : "Purkinje myocyte of atrioventricular node",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Purkinje myocyte that is part of the atrioventricular node.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83386"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000481",
      "lbl" : "transitional myocyte of atrioventricular bundle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transitional myocyte that is part of the atrioventricular bundle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83388"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000482",
      "lbl" : "myocardial endocrine cell of interventricular septum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myocardial endocrine cell that is part of the interventricular septum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83390"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000484",
      "lbl" : "Purkinje myocyte of atrioventricular bundle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Purkinje myocyte that is part of the atrioventricular bundle.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:83393"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000486",
      "lbl" : "basal cell of urothelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A basal cell that is part of the urothelium. Compared to other urothelial cell types, a basal cell of the urothelium is positioned along the basement membrane, is the most undifferentiated and serves a progenitor role.",
          "xrefs" : [ "GOC:tfm", "doi:10.1038/s41385-022-00565-0" ]
        },
        "comments" : [ "It has been noted in at least some mammalian species that the urothelial basal cell type is distinguished by expression of high levels of cytokeratin-5 (CK5), p63 and the signalling molecule Sonic hedgehog (Shh). Similar to intermediate cells, the urothelial basal cell type expresses CK17 but is negative for uroplakins (UPK) and CK20. Urothelial basal cells have also been noted to be smaller in diameter than urothelial intermediate cells." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "urothelial basal cell",
          "xrefs" : [ "doi:10.1007/978-3-030-14366-4_8", "doi:10.1111/cpr.13170" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:84150"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000487",
      "lbl" : "smooth muscle cell of prostate",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the prostate gland.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "smooth muscle fiber of prostate",
          "xrefs" : [ "FMA:84583" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:84583"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000488",
      "lbl" : "cholangiocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water. They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.",
          "xrefs" : [ "GOC:tfm", "PMID:16550043", "PMID:18356246" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epithelial cell of bile duct"
        } ],
        "xrefs" : [ {
          "val" : "FMA:86481"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000490",
      "lbl" : "mesothelial cell of peritoneum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the peritoneum.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "peritoneal mesothelial cell",
          "xrefs" : [ "FMA:86736" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:86736"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000491",
      "lbl" : "mesothelial cell of pleura",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the pleura.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pleural mesothelial cell",
          "xrefs" : [ "FMA:86737" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:86737"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000492",
      "lbl" : "mesothelial cell of parietal pleura",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the parietal pleura.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "xrefs" : [ {
          "val" : "FMA:86738"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000493",
      "lbl" : "mesothelial cell of visceral pleura",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mesothelial cell that is part of the visceral pleura.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "FMA:86739"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000494",
      "lbl" : "nephron tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of a nephron tubule.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "comments" : [ "This needs to be further defined as a juxtamedullary nephron. Will request the juxtamedullary nephron tubule class from UBERON." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "kidney tubule epithelial cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:86785"
        }, {
          "val" : "KUPO:0001022"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000495",
      "lbl" : "small intestine goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the small intestine.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of epithelium of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "goblet cell of small intestine"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "small intestinal goblet cell",
          "xrefs" : [ "FMA:86929" ]
        } ],
        "xrefs" : [ {
          "val" : "FMA:86929"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000497",
      "lbl" : "kidney cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a kidney."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001010"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000500",
      "lbl" : "kidney interstitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of kidney interstitium."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001013"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000504",
      "lbl" : "kidney medulla cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a renal medulla.",
          "xrefs" : [ "PMID:22343825" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001017"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000505",
      "lbl" : "kidney pelvis cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a renal pelvis."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001018"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000507",
      "lbl" : "kidney tubule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a nephron tubule."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001020"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000510",
      "lbl" : "kidney glomerular epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney epithelial cell that is part of some glomerular epithelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001023"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000546",
      "lbl" : "kidney medulla collecting duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of a renal medulla collecting duct."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001060"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000547",
      "lbl" : "kidney inner medulla collecting duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of some inner medullary collecting duct."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001061"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000548",
      "lbl" : "kidney outer medulla collecting duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of an outer medullary collecting duct."
        },
        "xrefs" : [ {
          "val" : "KUPO:0001062"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000549",
      "lbl" : "kidney cortex collecting duct epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of a cortical collecting duct."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001063"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000550",
      "lbl" : "kidney papillary duct principal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cell that is part of some papillary duct.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001064"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000600",
      "lbl" : "lower urinary tract cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some lower urinary tract.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001115"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000601",
      "lbl" : "ureteral cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some ureter.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001116"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000606",
      "lbl" : "kidney nerve cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that has its soma located in some kidney.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001015"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000612",
      "lbl" : "kidney corpuscule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal cortical epithelial cell that is part of some renal corpuscle.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001021"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000615",
      "lbl" : "kidney cortex tubule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney tubule cell that is part of some renal cortex tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001024"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000616",
      "lbl" : "kidney outer medulla cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney medulla cell that is part of some outer medulla of kidney.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001025"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000617",
      "lbl" : "kidney inner medulla cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney medulla cell that is part of some inner medulla of kidney.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001026"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000618",
      "lbl" : "juxtaglomerular complex cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cortical cell that is part of some juxtaglomerular apparatus.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "juxtaglomerulus cell",
          "xrefs" : [ "GO:0072052" ]
        } ],
        "xrefs" : [ {
          "val" : "KUPO:0001028"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000681",
      "lbl" : "kidney cortex interstitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of an interstitial compartment of a renal cortex.",
          "xrefs" : [ "PMID:18575881" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001091"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000682",
      "lbl" : "kidney medulla interstitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of an interstitum of a renal medulla.",
          "xrefs" : [ "PMID:21359760" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001092"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000692",
      "lbl" : "kidney interstitial fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of an interstitial compartment of a kidney.",
          "xrefs" : [ "PMID:10559635" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001102"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000702",
      "lbl" : "kidney pelvis smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some kidney pelvis smooth muscle.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001113"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000703",
      "lbl" : "kidney pelvis urothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney epithelial cell that is part of some kidney pelvis urothelium.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001114"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000706",
      "lbl" : "ureter urothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A urothelial cell that is part of the urothelium of ureter.",
          "xrefs" : [ "PMID:36180582" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001117"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000708",
      "lbl" : "ureter adventitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any ureteral cell that is part of some adventitia of ureter.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001119"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000714",
      "lbl" : "kidney cortex collecting duct principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal principal cell that is part of some cortical collecting duct.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001130"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000716",
      "lbl" : "kidney outer medulla collecting duct principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Principal cell that is part of some outer medullary collecting duct. It is known in some mammalian species that this cell may express the epithelial sodium channel (ENaC).",
          "xrefs" : [ "PMID:25632105" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001132"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000718",
      "lbl" : "kidney inner medulla collecting duct principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal principal cell that is part of some inner medullary collecting duct.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001134"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000721",
      "lbl" : "kidney papillary duct principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal principal cell that is part of some papillary duct.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001137"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000746",
      "lbl" : "glomerular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney corpuscule cell that is part of some renal glomerulus.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001036"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000803",
      "lbl" : "kidney inner medulla interstitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of an interstitial compartment of an inner renal medulla.",
          "xrefs" : [ "PMID:21359760" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001093"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000804",
      "lbl" : "kidney outer medulla interstitial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A kidney cell that is part of an interstitial compartment of an outer renal medulla.",
          "xrefs" : [ "PMID:8694267" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001094"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000838",
      "lbl" : "kidney proximal convoluted tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell of proximal tubule that is part of some proximal convoluted tubule and has part some brush border.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001045"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000839",
      "lbl" : "kidney proximal straight tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell of proximal tubule that is part of some proximal straight tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001046"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000849",
      "lbl" : "kidney distal convoluted tubule epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell of distal tubule that is part of some distal convoluted tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001056"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000850",
      "lbl" : "macula densa epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the macula densa, characterized by a tightly packed arrangement, apically positioned nuclei, and prominent primary cilia, creating a distinctive 'dense spot' appearance under microscopy. It is involved in regulating renal blood flow, glomerular filtration rate, and renin release.",
          "xrefs" : [ "PMID:33491562", "PMID:36142420", "Wikipedia:Macula_densa" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "macula densa cell",
          "xrefs" : [ "PMID:33491562" ]
        } ],
        "xrefs" : [ {
          "val" : "KUPO:0001057"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000854",
      "lbl" : "kidney blood vessel cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A blood vessel cell that is part of a kidney.",
          "xrefs" : [ "PMID:34843404" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001014"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000891",
      "lbl" : "kidney arterial blood vessel cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney blood vessel cell that is part of some kidney arterial blood vessel.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001029"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000892",
      "lbl" : "kidney capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the capillary of the kidney."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001030"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000893",
      "lbl" : "kidney venous blood vessel cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney blood vessel cell that is part of some renal vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001031"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000909",
      "lbl" : "kidney loop of Henle epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any nephron tubule epithelial cell that is part of some loop of Henle.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001047"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1000979",
      "lbl" : "ureter smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some muscular coat of ureter.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001118"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001005",
      "lbl" : "glomerular capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the glomerular capillary of the kidney."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001037"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001006",
      "lbl" : "kidney afferent arteriole cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell which is part of the afferent arteriole in the kidney. This cell is  responsible for maintaining renal blood flow and glomerular filtration rate.",
          "xrefs" : [ "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001038"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001009",
      "lbl" : "kidney efferent arteriole cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney arterial blood vessel cell that is part of some renal efferent arteriole.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001041"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001016",
      "lbl" : "kidney loop of Henle ascending limb epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney loop of Henle epithelial cell that is part of some ascending limb of loop of Henle.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001048"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001021",
      "lbl" : "kidney loop of Henle descending limb epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney loop of Henle epithelial cell that is part of some descending limb of loop of Henle.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#kidney_upper_slim" ],
        "xrefs" : [ {
          "val" : "KUPO:0001053"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001033",
      "lbl" : "peritubular capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the peritubular capillary of the kidney. This cell is highly fenestrated and plays a vital role in the kidney's filtration process, enabling the exchange of materials between the blood and the renal tubules.",
          "xrefs" : [ "PMID:19129259" ]
        },
        "comments" : [ "Peritubular capillary endothelial cells feature fenestrations measuring 60-70 nm in diameter, each traversed by a thin diaphragm." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001065"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001036",
      "lbl" : "vasa recta cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a vasa recta.",
          "xrefs" : [ "PMID:12529271", "PMID:24381184" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001068"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001045",
      "lbl" : "kidney cortex artery cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney arterial blood vessel cell that is part of some renal cortex artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001077"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001052",
      "lbl" : "kidney cortex vein cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney venous blood vessel cell that is part of some renal cortex vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001084"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001064",
      "lbl" : "kidney artery smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Note that the source of this term is KUPO:0001096 (artery smooth muscle cell), which we believe actually denotes the kidney specific structure." ],
        "xrefs" : [ {
          "val" : "KUPO:0001096"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001066",
      "lbl" : "kidney arteriole smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Note that the source of this term is KUPO:0001098 (arteriole smooth muscle cell), which we believe actually denotes the kidney specific structure." ],
        "xrefs" : [ {
          "val" : "KUPO:0001098"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001068",
      "lbl" : "kidney venous system smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "comments" : [ "Note that the source of this term is KUPO:0001068 (venous system smooth muscle cell), which we believe actually denotes the kidney specific structure." ],
        "xrefs" : [ {
          "val" : "KUPO:0001100"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001096",
      "lbl" : "kidney afferent arteriole endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that lines the interior surface of the afferent arteriole and maintains vascular tone. This cell responds to changing ion concentrations and blood pressure by releasing vasoactive substances, in order to regulate blood flow into the glomeruli, which is essential for glomerular filtration.",
          "xrefs" : [ "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001039"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001097",
      "lbl" : "kidney afferent arteriole smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell found in the wall of the afferent arteriole. This cell contracts and relaxes in response to changes in blood pressure, a process known as a myogenic response, to alter artery diameter and regulate blood flow into the glomeruli.",
          "xrefs" : [ "PMID:16990493", "PMID:22733355", "PMID:24066938", "PMID:25834230" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001040"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001099",
      "lbl" : "kidney efferent arteriole endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some renal efferent arteriole.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001042"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001100",
      "lbl" : "kidney efferent arteriole smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some renal efferent arteriole.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001043"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001106",
      "lbl" : "kidney loop of Henle thick ascending limb epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of some loop of Henle thick ascending limb. It is known in some mammalian species that this cell may express the Na+-K+-2Cl− cotransporter (NKCC2) apically.",
          "xrefs" : [ "PMID:25318757" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001049"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001107",
      "lbl" : "kidney loop of Henle thin ascending limb epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of some loop of Henle thin ascending limb."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001050"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001111",
      "lbl" : "kidney loop of Henle thin descending limb epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of some loop of Henle thin descending limb."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001054"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001123",
      "lbl" : "kidney outer medulla peritubular capillary cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the peritubular capillary of the outer renal medulla."
        },
        "xrefs" : [ {
          "val" : "KUPO:0001066"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001124",
      "lbl" : "kidney cortex peritubular capillary cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of the peritubular capillary of the renal cortex."
        },
        "xrefs" : [ {
          "val" : "KUPO:0001067"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001126",
      "lbl" : "inner renal medulla vasa recta cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any vasa recta cell that is part of some inner renal medulla vasa recta.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001069"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001127",
      "lbl" : "outer renal medulla vasa recta cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any vasa recta cell that is part of some outer renal medulla vasa recta.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001070"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001135",
      "lbl" : "arcuate artery cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cortex artery cell that is part of some kidney arcuate artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001078"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001138",
      "lbl" : "interlobular artery cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cortex artery cell that is part of some interlobular artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001081"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001142",
      "lbl" : "arcuate vein cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cortex vein cell that is part of some kidney arcuate vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001085"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001145",
      "lbl" : "interlobular vein cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any kidney cortex vein cell that is part of some renal interlobular vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001088"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001213",
      "lbl" : "arcuate artery endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some kidney arcuate artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001079"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001214",
      "lbl" : "arcuate artery smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some kidney arcuate artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001080"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001216",
      "lbl" : "interlobulary artery endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some interlobular artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001082"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001217",
      "lbl" : "interlobulary artery smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some interlobular artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001083"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001220",
      "lbl" : "arcuate vein endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some kidney arcuate vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001086"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001221",
      "lbl" : "arcuate vein smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some kidney arcuate vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001087"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001223",
      "lbl" : "interlobulary vein endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell that is part of some renal interlobular vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001089"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001224",
      "lbl" : "interlobulary vein smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any smooth muscle cell that is part of some renal interlobular vein.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001090"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001225",
      "lbl" : "kidney collecting duct cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is part of a collecting duct of renal tubule."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001012"
        }, {
          "val" : "Wikipedia:Kidney_collecting_duct_cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001318",
      "lbl" : "renal interstitial pericyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pericyte cell located in the kidney interstitium."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001104"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001319",
      "lbl" : "bladder cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some urinary bladder.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001120"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001320",
      "lbl" : "urethra cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of some urethra.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "xrefs" : [ {
          "val" : "KUPO:0001123"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001428",
      "lbl" : "bladder urothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A urothelial cell that is part of the urothelium of the urinary bladder.",
          "xrefs" : [ "doi:10.1038/s41385-022-00565-0" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "bladder transitional cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "transitional epithelial cell of urinary bladder"
        } ],
        "xrefs" : [ {
          "val" : "KUPO:0001121"
        }, {
          "val" : "NCIT:C32210"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001430",
      "lbl" : "urethra urothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A urothelial cell that is part of the urethra urothelium. This cell plays a crucial role in maintaining the urethral barrier function, protecting against toxic substances in urine, sensing environmental changes, and defending against pathogen entry.",
          "xrefs" : [ "PMID:23589830", "PMID:36180582" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "KUPO:0001124"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001431",
      "lbl" : "kidney collecting duct principal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal principal cell that is part of some collecting duct of renal tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001128"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001432",
      "lbl" : "kidney collecting duct intercalated cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any renal intercalated cell that is part of some collecting duct of renal tubule.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
          "val" : "KUPO:0001129"
        }, {
          "val" : "http://en.wikipedia.org/wiki/Collecting_duct_system#Intercalated_cells"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001433",
      "lbl" : "epithelial cell of exocrine pancreas",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell of the exocrine pancreas.",
          "xrefs" : [ "GOC:tfm" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "exocrine pancreas cell"
        } ],
        "xrefs" : [ {
          "val" : "FMA:70986"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001434",
      "lbl" : "olfactory bulb interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron residing in the olfactory bulb that serve to process and refine signals arising from olfactory sensory neurons",
          "xrefs" : [ "PMID:18603310" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001435",
      "lbl" : "periglomerular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter.",
          "xrefs" : [ "MP:0009943" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glomerular layer cell",
          "xrefs" : [ "NIFEXT:122" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory bulb (accessory) glomerular layer cell",
          "xrefs" : [ "NIFEXT:122" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory bulb glomerular layer cell",
          "xrefs" : [ "NIFEXT:122" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory bulb glomerularal cell",
          "xrefs" : [ "MP:0009943" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "olfactory bulb periglomerular cell"
        } ],
        "xrefs" : [ {
          "val" : "BTO:0003796"
        }, {
          "val" : "NIFEXT:122"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001436",
      "lbl" : "hair-tylotrich neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The subcutaneous mechanoreceptors that innervate tylotrich hair follicles.",
          "xrefs" : [ "MP:0000977" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001437",
      "lbl" : "hair-down neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The subcutaneous mechanoreceptors that innervate vellus hairs.",
          "xrefs" : [ "MP:0000979" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001451",
      "lbl" : "sensory neuron of dorsal root ganglion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A sensory neuron of the dorsal root ganglia that senses body position and sends information about how much the muscle is stretched to the spinal cord.",
          "xrefs" : [ "MP:0004297" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "proprioceptive neuron",
          "xrefs" : [ "MP:0004297" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001474",
      "lbl" : "medium spiny neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An inhibitory, GABAergic projection neuron in the striatum that integrates glutamatergic signals arising from the cerebral cortex and thalamus.",
          "xrefs" : [ "MP:0008462", "doi:10.1073/pnas.242428599" ]
        },
        "comments" : [ "Direct genetic lineage tracing in mice, including Dlx-based and Sp9-Cre fate mapping, demonstrates that medium spiny neurons (MSNs) originate from progenitors in the lateral ganglionic eminence (LGE), with labeled cells migrating from LGE to the striatum and expressing MSN markers such as FOXP1 and CTIP2." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gamma-aminobutyric acid (GABA)ergic spiny projection neuron",
          "xrefs" : [ "doi:10.1073/pnas.242428599" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-aminobutyric acid ergic spiny projection neuron",
          "xrefs" : [ "doi:10.1073/pnas.242428599" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "striatal medium spiny neuron",
          "xrefs" : [ "GO:0021773" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "medium-sized densely spiny neuron",
          "xrefs" : [ "BTO:0004778" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0004778"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001502",
      "lbl" : "mitral cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The large glutaminergic nerve cells whose dendrites synapse with axons of the olfactory receptor neurons in the glomerular layer of the olfactory bulb, and whose axons pass centrally in the olfactory tract to the olfactory cortex.",
          "xrefs" : [ "MP:0009954" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001503",
      "lbl" : "olfactory bulb tufted cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The principal glutaminergic neuron located in the outer third of the external plexiform layer of the olfactory bulb; a single short primary dendrite traverses the outer external plexiform layer and terminates within an olfactory glomerulus in a tuft of branches, where it receives the input from olfactory receptor neuron axon terminals; axons of the tufted cells transfer information to a number of areas in the brain, including the piriform cortex, entorhinal cortex, olfactory tubercle, and amygdala.",
          "xrefs" : [ "MP:0009955" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001505",
      "lbl" : "parvocellular neurosecretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The secretory neurons of the paraventricular nucleus that synthesize and secrete vasopressin, corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) into blood vessels in the hypothalamo-pituitary portal system.",
          "xrefs" : [ "MP:0010125" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "parvocellular neuron"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "parvocellular neurosecretory neuron"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001509",
      "lbl" : "glycinergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The neurons that utilize glycine as a neurotransmitter.",
          "xrefs" : [ "MP:0010385" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001516",
      "lbl" : "intestinal enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the intestinal tract.",
          "xrefs" : [ "MP:0010802" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001517",
      "lbl" : "stomach enteroendocrine cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The various hormone- or neurotransmitter-secreting cells present throughout the mucosa of the stomach.",
          "xrefs" : [ "MP:0010803" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001561",
      "lbl" : "vomeronasal sensory neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Chemosensitive cells that innervate the vomernasal organ epithelium and are responsible for receiving and transmitting pheromone signals.",
          "xrefs" : [ "MP:0011679" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001567",
      "lbl" : "lung endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell of vascular tree that is part of some lung.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "endothelial cell of lung"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pulmonary vessel endothelial cell"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001568",
      "lbl" : "pulmonary artery endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell of vascular tree that is part of some pulmonary artery.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "PAEC cell",
          "xrefs" : [ "BTO:0001141" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0001141"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001569",
      "lbl" : "hippocampal interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An interneuron with a soma found in the hippocampus.",
          "xrefs" : [ "GOC:pr" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "FMA:84777"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001571",
      "lbl" : "hippocampal pyramidal neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A pyramidal neuron with a soma found in the hippocampus.",
          "xrefs" : [ "GOC:pr", "PMID:19342486" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "hippocampus (CA) pyramidal cell",
          "xrefs" : [ "NIFSTD:sao131261273" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "hippocampus (CA) pyramidal neuron",
          "xrefs" : [ "NIFSTD:sao131261273" ]
        } ],
        "xrefs" : [ {
          "val" : "NIFSTD:sao131261273"
        }, {
          "val" : "SAO:sao131261273"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001572",
      "lbl" : "colon endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A vascular endothelial cell found in colon blood vessels.",
          "xrefs" : [ "NPX:PDR", "https://orcid.org/0000-0001-5208-3432" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "colonic endothelial cell",
          "xrefs" : [ "CALOHA:TS-2397" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2397"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001573",
      "lbl" : "nasopharyngeal epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell of the nasopharyngeal epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "nasopharynx respiratory epithelial cells",
          "xrefs" : [ "CALOHA:TS-2398" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2398"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001575",
      "lbl" : "uterine cervix squamous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Squamous cell of uterine cervix epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix squamous cell",
          "xrefs" : [ "CALOHA:TS-1251" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1251" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix, uterine squamous epithelial cells",
          "xrefs" : [ "CALOHA:TS-1251" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "uterine cervix squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1251" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "uterine cervix squamous epithelial cells",
          "xrefs" : [ "CALOHA:TS-1251" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1251"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001576",
      "lbl" : "oral mucosa squamous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Squamous cell of oral epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "oral cavity mucosa squamous cell",
          "xrefs" : [ "CALOHA:TS-1252" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "oral cavity mucosa squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1252" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "oral mucosa squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1252" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "oral mucosa squamous epithelial cells",
          "xrefs" : [ "CALOHA:TS-1252" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1252"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001577",
      "lbl" : "tonsil squamous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Squamous cell of tonsil epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "tonsil squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1253" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tonsil squamous epithelial cells",
          "xrefs" : [ "CALOHA:TS-1253" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tonsillar squamous cell",
          "xrefs" : [ "CALOHA:TS-1253" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tonsillar squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1253" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1253"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001578",
      "lbl" : "vagina squamous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Squamous cell of vaginal epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "vagina squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1254" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "vagina squamous epithelial cells",
          "xrefs" : [ "CALOHA:TS-1254" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "vaginal squamous cell",
          "xrefs" : [ "CALOHA:TS-1254" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "vaginal squamous epithelial cell",
          "xrefs" : [ "CALOHA:TS-1254" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1254"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001579",
      "lbl" : "cerebral cortex glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glial cell of cerebral cortex.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "brain cortex glial cell",
          "xrefs" : [ "CALOHA:TS-1256" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cerebral cortex glial cells",
          "xrefs" : [ "CALOHA:TS-1256" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cerebrum cortex glial cell",
          "xrefs" : [ "CALOHA:TS-1256" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1256"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001580",
      "lbl" : "hippocampal glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glial cell that is part of the hippocampus.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hippocampus glial cell",
          "xrefs" : [ "CALOHA:TS-1257" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hippocampus neuroglial cell",
          "xrefs" : [ "CALOHA:TS-1257" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1257"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001581",
      "lbl" : "lateral ventricle glial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glial cell of lateral ventricle.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "lateral ventricle glial cells",
          "xrefs" : [ "CALOHA:TS-1258" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1258"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001582",
      "lbl" : "lateral ventricle neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Neuron of lateral ventricle.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "lateral ventricle neural cell",
          "xrefs" : [ "CALOHA:TS-1261" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lateral ventricle neuronal cell",
          "xrefs" : [ "CALOHA:TS-1261" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lateral ventricle neuronal cells",
          "xrefs" : [ "CALOHA:TS-1261" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1261"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001586",
      "lbl" : "mammary gland glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of mammary epithelium. Example: glandular cells of large and intermediate ducts, glandular cells in terminal ducts.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "breast glandular cell",
          "xrefs" : [ "CALOHA:TS-1272" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "breast glandular cells",
          "xrefs" : [ "CALOHA:TS-1272" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mammary glandular cell",
          "xrefs" : [ "CALOHA:TS-1272" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1272"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001587",
      "lbl" : "uterine cervix secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of uterine cervix epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix glandular cell",
          "xrefs" : [ "CALOHA:TS-1273" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix, uterine glandular cell",
          "xrefs" : [ "CALOHA:TS-1273" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cervix, uterine glandular cells",
          "xrefs" : [ "CALOHA:TS-1273" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "uterine cervix glandular cell"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1273"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001588",
      "lbl" : "colon glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of colon epithelium. Example: Goblet cells; enterocytes or absorptive cells; enteroendocrine and M cells.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "colon glandular cells",
          "xrefs" : [ "CALOHA:TS-1274" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1274"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001589",
      "lbl" : "duodenum secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of duodenal epithelium. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Brunner's gland cell.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "duodenum glandular cells",
          "xrefs" : [ "CALOHA:TS-1275" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1275"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001590",
      "lbl" : "epididymis secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of epididymal epithelium.",
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        },
        "synonyms" : [ {
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          "val" : "epididymal glandular cell",
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        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "epididymis glandular cell",
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        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1276"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001591",
      "lbl" : "oviduct secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of oviduct epithelium. Example: peg cells, ciliated cells.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "fallopian tube glandular cell",
          "xrefs" : [ "CALOHA:TS-1277" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "fallopian tube glandular cells",
          "xrefs" : [ "CALOHA:TS-1277" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "oviduct glandular cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "uterine tube glandular cell",
          "xrefs" : [ "CALOHA:TS-1277" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1277"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001592",
      "lbl" : "gallbladder glandular cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Glandular cell of gallbladder epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gall bladder glandular cell",
          "xrefs" : [ "FMA:7202" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "gall bladder glandular cells",
          "xrefs" : [ "CALOHA:TS-1278" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "gallbladder glandular cells",
          "xrefs" : [ "CALOHA:TS-1278" ]
        } ],
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          "val" : "CALOHA:TS-1278"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001593",
      "lbl" : "parathyroid glandular cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Glandular (secretory) cell of parathyroid epithelium.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
        "synonyms" : [ {
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          "val" : "parathyroid gland glandular cell",
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        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "parathyroid gland glandular cells",
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        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1279"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001595",
      "lbl" : "rectum glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of rectal epithelium. Example: Goblet cell; enterocytes or absorptive cells; enteroendocrine and M cells.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
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          "val" : "rectal glandular cell",
          "xrefs" : [ "CALOHA:TS-1281" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "rectum glandular cells",
          "xrefs" : [ "CALOHA:TS-1281" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1281"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001596",
      "lbl" : "salivary gland glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of salivary gland. Example: Serous cells, mucous cells, cuboidal epithelial cells of the intercalated ducts, simple cuboidal epithelium of the striated ducts, epithelial cells of excretory ducts.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "salivary gland glandular cells",
          "xrefs" : [ "CALOHA:TS-1282" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1282"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001597",
      "lbl" : "seminal vesicle glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of seminal vesicle epithelium.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "seminal vesicle glandular cells",
          "xrefs" : [ "CALOHA:TS-1283" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1283"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001598",
      "lbl" : "small intestine secretory cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A glandular cell found in the epithelium of the small intestine. Example: Enterocytes, Goblet cells, enteroendocrine cells; Paneth cells; M cells; Somatostatin-secreting Cells (D-cells) .",
          "xrefs" : [ "NCI_Thesaurus:Small_Intestinal_Glandular_Cell", "NPX:PDR" ]
        },
        "synonyms" : [ {
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          "val" : "small intestinal glandular cell",
          "xrefs" : [ "CALOHA:TS-1286" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "small bowel glandular cell",
          "xrefs" : [ "CALOHA:TS-1286" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "small intestine glandular cells",
          "xrefs" : [ "CALOHA:TS-1286" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-1286"
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          "val" : "FMA:86928"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001599",
      "lbl" : "pancreas exocrine glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glandular cell of exocrine pancreas epithelium. Example: pancreatic acinar cell, glandular cells in pancreatic canaliculi, glandular cells in pancreatic ducts.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
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        "synonyms" : [ {
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          "val" : "exocrine pancreas glandular cell",
          "xrefs" : [ "CALOHA:TS-1242" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pancreas exocrine glandular cells",
          "xrefs" : [ "CALOHA:TS-1242" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0000028"
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          "val" : "CALOHA:TS-1242"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001601",
      "lbl" : "adrenal gland glandular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Hormone secreting cell located in the cortex of adrenal gland. Glandular cells in the adrenal cortex secrete mineralocorticoids, glucocorticoids and androgens.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
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          "val" : "adrenal gland glandular cells",
          "xrefs" : [ "CALOHA:TS-2177" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "adrenal glandular cell",
          "xrefs" : [ "CALOHA:TS-2177" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "suprarenal gland glandular cell",
          "xrefs" : [ "CALOHA:TS-2177" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2177"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001602",
      "lbl" : "cerebral cortex endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A distinct endothelial cell forming the walls of the capillaries within the cerebral cortex.",
          "xrefs" : [ "NPX:PDR" ]
        },
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        "synonyms" : [ {
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          "val" : "cerebral cortex endothelial cells",
          "xrefs" : [ "CALOHA:TS-2372" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "endothelial cells of cerebral cortex",
          "xrefs" : [ "CALOHA:TS-2372" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2372"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001603",
      "lbl" : "lung macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.",
          "xrefs" : [ "HPA:HPA", "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
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          "val" : "lung macrophages",
          "xrefs" : [ "CALOHA:TS-0576" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0576"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001606",
      "lbl" : "foreskin keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Keratinocyte from foreskin.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "xrefs" : [ {
          "val" : "CALOHA:TS-0385"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001607",
      "lbl" : "articular chondrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Chondrocyte forming the hyaline cartilage found in joints.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "xrefs" : [ {
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_1001608",
      "lbl" : "foreskin fibroblast",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Fibroblast from foreskin.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "BJ fibroblast"
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0384"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001609",
      "lbl" : "muscle fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Fibroblast from muscle organ.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-0643"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001610",
      "lbl" : "bone marrow hematopoietic cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Hematopoietic cells resident in the bone marrow. Include: hematopoietic stem cells (lymphoid stem cells and myeloid stem cells) and the precursor cells for thrombocytes, erythrocytes, basophils, neutrophils, eosinophils, monocytes and lymphocytes.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "bone marrow hematopoietic cells",
          "xrefs" : [ "CALOHA:TS-2109" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "bone marrow poietic cells",
          "xrefs" : [ "CALOHA:TS-2109" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2109"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_1001611",
      "lbl" : "cerebellar neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Neuron of the cerebellum.",
          "xrefs" : [ "NPX:PDR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cerebellum neuron",
          "xrefs" : [ "CALOHA:TS-2359" ]
        } ],
        "xrefs" : [ {
          "val" : "CALOHA:TS-2359"
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          "val" : "FMA:84665"
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_1100001",
      "lbl" : "secretory epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is specialised for the synthesis and secretion of specific biomolecules.",
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        },
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-7073-9172"
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-07-21T09:24:44Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000000",
      "lbl" : "epidermal melanocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any melanocyte that is part of a epidermis.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "comments" : [ "These cells are found primarily, but not exclusively, in primates including humans" ],
        "basicPropertyValues" : [ {
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          "val" : "2014-02-03T23:03:09Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000001",
      "lbl" : "peripheral blood mononuclear cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A leukocyte with a single non-segmented nucleus in the mature form found in the circulatory pool of blood.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "2014-02-11T17:29:04Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000002",
      "lbl" : "decidual cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized, enlarged, connective tissue cell of the decidua with enlarged nucleus, dense membrane‐bound secretory granules and cytoplasmic accumulation of glycogen and lipid droplets. These cells develop by the transformation of endometrial stromal cells during decidualization.",
          "xrefs" : [ "BTO:0002770", "NCIT:C32429", "PMID:30013421", "PMID:30429548", "Wiki:Decidual_cells&oldid=937509751", "Wiki:Decidualization&oldid=908981933" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "decidua cell",
          "xrefs" : [ "BTO:0002770", "NCIT:C32429" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "decidual stromal cell",
          "xrefs" : [ "BTO:0005756", "PMID:11719592" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "decidualized endometrial stromal cell",
          "xrefs" : [ "PMID:31907034" ]
        } ],
        "xrefs" : [ {
          "val" : "BTO:0002770"
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          "val" : "BTO:0005756"
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          "val" : "NCIT:C32429"
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        "basicPropertyValues" : [ {
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          "val" : "2014-02-20T23:06:41Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000004",
      "lbl" : "pituitary gland cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cell that is part of a pituitary gland.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2014-03-26T22:14:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000005",
      "lbl" : "brain macroglial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any macroglial cell that is part of a brain.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-03-28T21:35:27Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000006",
      "lbl" : "tonsil germinal center B cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any germinal center B cell that is part of a tonsil.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2014-03-28T21:35:33Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000007",
      "lbl" : "articular chondrocyte of knee joint",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Chondrocyte forming the hyaline cartilage found in the knee joint.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-06-04T14:40:11Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000008",
      "lbl" : "microvascular endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any blood vessel endothelial cell that is part of a microvascular endothelium.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "2014-06-04T15:07:42Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000010",
      "lbl" : "dermis blood vessel endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any blood vessel endothelial cell that is part of a dermis.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-06-04T15:12:06Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000011",
      "lbl" : "dermis lymphatic vessel endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any endothelial cell of lymphatic vessel that is part of a dermis.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/CL_2000012",
      "lbl" : "fibroblast of pedal digit skin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any skin fibroblast that is part of a pedal digit skin.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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      "lbl" : "fibroblast of skin of abdomen",
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      "lbl" : "fibroblast of upper leg skin",
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      "lbl" : "fibroblast of arm",
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      "lbl" : "lung microvascular endothelial cell",
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      "lbl" : "fibroblast of peridontal ligament",
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        "definition" : {
          "val" : "Any fibroblast that is part of a periodontal ligament.",
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      "lbl" : "endothelial cell of coronary artery",
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      "lbl" : "compound eye photoreceptor cell",
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        "definition" : {
          "val" : "Any photoreceptor cell that is part of a compound eye.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000020",
      "lbl" : "inner cell mass cell",
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        "definition" : {
          "val" : "Any native cell that is part of a inner cell mass.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000021",
      "lbl" : "sebaceous gland cell",
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        "definition" : {
          "val" : "Any native cell that is part of a sebaceous gland.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000022",
      "lbl" : "cardiac septum cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any native cell that is part of a cardiac septum.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000023",
      "lbl" : "spinal cord ventral column interneuron",
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        "definition" : {
          "val" : "Any interneuron that is part of a spinal cord ventral column.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000024",
      "lbl" : "spinal cord medial motor column neuron",
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          "val" : "Any neuron that is part of a spinal cord medial motor column.",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000025",
      "lbl" : "spinal cord oligodendrocyte",
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      "lbl" : "cerebellar basket cell",
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      "lbl" : "cerebellum glutamatergic neuron",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000030",
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      "lbl" : "lateral line ganglion neuron",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000032",
      "lbl" : "peripheral nervous system neuron",
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      "lbl" : "limb basal cell of epidermis",
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      "id" : "http://purl.obolibrary.org/obo/CL_2000040",
      "lbl" : "bladder microvascular endothelial cell",
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      "lbl" : "dermis microvascular lymphatic vessel endothelial cell",
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      "lbl" : "foreskin melanocyte",
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      "lbl" : "ventricular cardiac muscle cell",
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          "val" : "Any cardiac muscle cell that is part of a cardiac ventricle.",
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      "lbl" : "splenic fibroblast",
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      "lbl" : "splenic endothelial cell",
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      "lbl" : "liver dendritic cell",
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        "comments" : [ "http://www.jleukbio.org/content/66/2/322.abstract" ],
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        "comments" : [ "Same as synctial trophoblast?" ],
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        "comments" : [ "http://www.ncbi.nlm.nih.gov/books/NBK53245/" ],
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        "comments" : [ "Splenocytes is a vague term that refers to any one of the different white blood cell types in the spleen. This name is seen many references as such and is not explained further, necessitating a need for this terminology." ],
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      "id" : "http://purl.obolibrary.org/obo/CL_2000084",
      "lbl" : "conjunctiva goblet cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A goblet cell that is part of the conjunctival epithelium, characterized by apical accumulation of mucin granules (containing MUC5AC in humans; Muc5ac/Muc5b in mice). These gel-forming mucins support tear film stability, ocular lubrication, and pathogen defence. The conjunctival goblet cell forms tight junctions with neighbouring epithelial cells via species-specific claudins (claudin-10 in humans, claudin-2 in mice) and regulates immune homeostasis by facilitating soluble antigen transport to dendritic cells through goblet cell-associated antigen passages (GAPs) (Barbosa et al., 2017). The transcription factor SPDEF is essential for its differentiation.",
          "xrefs" : [ "GOC:TermGenie", "PMID:27091323", "PMID:28475124", "PMID:31734511" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2014-12-02T19:28:38Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000085",
      "lbl" : "mononuclear cell of umbilical cord",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any mononuclear cell that is part of a umbilical cord.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-12-02T20:14:16Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000086",
      "lbl" : "neocortex basket cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any basket cell that is part of a neocortex.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-12-24T00:37:19Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000087",
      "lbl" : "dentate gyrus of hippocampal formation basket cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any basket cell that is part of a dentate gyrus of hippocampal formation.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-12-24T00:37:24Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000088",
      "lbl" : "Ammon's horn basket cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any basket cell that is part of a Ammon's horn.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2014-12-24T00:37:30Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000089",
      "lbl" : "dentate gyrus granule cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus granule cell is the principal cell type of the dentate gyrus.",
          "xrefs" : [ "GOC:TermGenie", "PMID:17765709" ]
        },
        "comments" : [ "As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body." ],
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          "pred" : "hasExactSynonym",
          "val" : "dentate gyrus of hippocampal formation granule cell"
        } ],
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          "val" : "2015-02-23T05:48:23Z"
        } ]
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      "id" : "http://purl.obolibrary.org/obo/CL_2000090",
      "lbl" : "dentate gyrus of hippocampal formation stellate cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any stellate cell that is part of a dentate gyrus of hippocampal formation.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2015-02-23T05:48:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000091",
      "lbl" : "endometrial microvascular endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any microvascular endothelial cell that is part of a endometrial blood vessel.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2015-03-31T21:02:36Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_2000092",
      "lbl" : "hair follicular keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any keratinocyte that is part of a hair follicle.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2015-03-31T21:07:02Z"
        } ]
      }
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      "id" : "http://purl.obolibrary.org/obo/CL_2000093",
      "lbl" : "bronchus fibroblast of lung",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any fibroblast of lung that is part of a bronchus.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2015-03-31T21:16:22Z"
        } ]
      }
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      "id" : "http://purl.obolibrary.org/obo/CL_2000095",
      "lbl" : "cord blood hematopoietic stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any hematopoietic stem cell that is part of a umbilical cord blood.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2015-05-26T18:58:34Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_2000096",
      "lbl" : "fibroblast of the reticular layer of dermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast of dermis that resides in the deep reticular layer, characterised by robust extracellular matrix production with high type I collagen deposition forming densely packed, organised fibrillar networks (Ghetti et al., 2018). This cell exhibits pro-fibrotic properties during wound healing, entering wounds early where it proliferates and deposits collagen to restore dermal architecture (Knoedler et al., 2023; McAndrews et al., 2022). It is distinguished from papillary dermal fibroblasts by expression of COL11A1, POSTN, and SPP1 in humans (Wu et al., 2022).",
          "xrefs" : [ "GOC:TermGenie", "PMID:29266210", "PMID:35212000", "PMID:36232952", "PMID:37646029" ]
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          "val" : "reticular fibroblast",
          "xrefs" : [ "PMID:29266210" ]
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          "val" : "https://orcid.org/0009-0000-8480-9277"
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          "val" : "2015-08-11T16:28:16Z"
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_2000097",
      "lbl" : "midbrain dopaminergic neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any dopaminergic neuron that is part of a midbrain.",
          "xrefs" : [ "GOC:TermGenie" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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          "val" : "2015-12-03T16:42:40Z"
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_3000004",
      "lbl" : "peripheral sensory neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron type that is located in a peripheral nervous system and it transmits sensory information from the peripheral (PNS) to the central nervous system (CNS). A sensory neuron converts physical (light, sound, touch) or chemical (such as taste and smell) stimuli into an electrical signal through a process known as sensory transduction. The function of a sensory neuron is to carry informations from the external environment and internal body conditions to the central nervous system for further processing.",
          "xrefs" : [ "GOC:CellBLAST", "PMID:30096314", "PMID:31554486", "PMID:35858549", "Wikipedia:Sensory_neuron", "https://www.britannica.com/science/sensory-neuron", "https://www.ncbi.nlm.nih.gov/books/NBK539846/" ]
        },
        "comments" : [ "Typically, a sensory neuron has a pseudounipolar morphology." ],
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          "val" : "http://www.wikidata.org/entity/Q97529981"
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          "val" : "2019-02-25T19:34:33Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4006000",
      "lbl" : "fibroblast of breast",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A fibroblast that is part of the breast."
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "breast fibroblast"
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          "val" : "https://orcid.org/0000-0001-9897-3238"
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      }
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      "id" : "http://purl.obolibrary.org/obo/CL_4006001",
      "lbl" : "fibroblast of skin of scalp",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast that is part of the skin of scalp."
        },
        "synonyms" : [ {
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          "val" : "skin of scalp fibroblast"
        } ],
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/CL_4023035",
      "lbl" : "lateral ganglionic eminence derived neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that is derived from a precursor cell in the lateral ganglion eminence.",
          "xrefs" : [ "wikipediaversioned:Ganglionic_eminence&oldid=1186824360" ]
        },
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          "val" : "LGE-derived neuron",
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          "val" : "https://orcid.org/0000-0002-7073-9172"
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      "id" : "http://purl.obolibrary.org/obo/CL_4023039",
      "lbl" : "amygdala excitatory neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any neuron that has its soma located in some amygdala and is capable of some glutamate secretion, neurotransmission.",
          "xrefs" : [ "FBC:Autogenerated" ]
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        "comments" : [ "An excitatory neuron that is located in the amygdala." ],
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      "lbl" : "cerebellar inhibitory GABAergic interneuron",
      "type" : "CLASS",
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          "val" : "A GABAergic interneuron whose soma is located in the cerebellar cortex.",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
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      "lbl" : "committed oligodendrocyte precursor",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An oligodendrocyte precursor cell that is committed to differentiate.",
          "xrefs" : [ "PMID:32066987" ]
        },
        "comments" : [ "COPs are distinct from OPCs in that the lack expression of Pdgfra and Cspg4 and come out as distinct clusters in transcriptomic profiling. This is the reason that this term is not modelled as a subclassOf OPC but instead linked using develops_from." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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          "val" : "differentiation-committed oligodendrocyte precursor"
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      "lbl" : "dentate gyrus neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A neuron with its soma located in the dentate gyrus of the hippocampus."
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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      "lbl" : "medial ganglionic eminence derived interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An interneuron that is derived from the medial ganglionic eminence.",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
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      "lbl" : "caudal ganglionic eminence derived interneuron",
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      "id" : "http://purl.obolibrary.org/obo/CL_4023068",
      "lbl" : "thalamic excitatory neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An excitatory neuron that has its soma located in the thalamic complex. This neuron type can be involved in a series of circuits related to sensory integration, motor integration, pain processing, social behaviour and reward response.",
          "xrefs" : [ "PMID:30083593", "PMID:31196673", "PMID:35278647", "PMID:37163009", "PMID:37824663", "PMID:38739251" ]
        },
        "comments" : [ "Abnormalities in glutametergic neurons of the thalamic complex are associated with pathologies such as schizophrenia, colorectal visceral pain and Parkinson's disease." ],
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      "lbl" : "medial ganglionic eminence derived GABAergic interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A GABAergic interneuron that develops from the medial ganglionic eminence and has migrated to the cerebral cortex.",
          "xrefs" : [ "PMID:12637172" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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      "id" : "http://purl.obolibrary.org/obo/CL_4023072",
      "lbl" : "brain vascular cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A cell that is part of the brain vasculature.",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
        },
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      "lbl" : "mammillary body neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A neuron that has its soma located in the mammillary body.",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
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      "lbl" : "midbrain-derived inhibitory neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A GABAergic inhibitory neuron that is derived from the midbrain.",
          "xrefs" : [ "DOI:10.1101/2022.10.12.511898" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_4023109",
      "lbl" : "vasopressin-secreting magnocellular cell",
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          "val" : "A magnocellular neurosecretory cell that is capable of producing and secreting vasopressin.",
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      "lbl" : "amygdala pyramidal neuron",
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        "definition" : {
          "val" : "A pyramidal neuron with soma located in the amygdala.",
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        "basicPropertyValues" : [ {
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      "lbl" : "cerebral cortex pyramidal neuron",
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          "val" : "A pyramidal neuron with soma located in the cerebral cortex.",
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      "id" : "http://purl.obolibrary.org/obo/CL_4023120",
      "lbl" : "cochlea auditory hair cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An auditory hair cell found in the cochlea.",
          "xrefs" : [ "Wikipedia:Hair_cell" ]
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          "val" : "cochlear hair cell"
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          "val" : "FMA:62364"
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      "id" : "http://purl.obolibrary.org/obo/CL_4023154",
      "lbl" : "myelinating glial cell",
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        "definition" : {
          "val" : "A glial cell that myelinates axonal processes.",
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      "id" : "http://purl.obolibrary.org/obo/CL_4023161",
      "lbl" : "unipolar brush cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An excitatory glutamatergic interneuron found in the granular layer of the cerebellar cortex and also in the granule cell domain of the cochlear nucleus. Unipolar brush cells have a round or oval cell body with usually a single short dendrite that ends in a brush-like tuft of short dendrites unique to them known as dendrioles.",
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          "val" : "neuronal brush cell"
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      "id" : "http://purl.obolibrary.org/obo/CL_4023168",
      "lbl" : "somatosensory neuron",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A neuron that is part of the somatic sensory system. Somatosensory neurons innervate the skin or integument to detect different types of thermal, chemical, and mechanical touch stimuli.",
          "xrefs" : [ "PMID:22865660" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_4028001",
      "lbl" : "pulmonary capillary endothelial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any capillary endothelial cell that is part of a lung."
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
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          "val" : "lung capillary endothelial cell"
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          "val" : "2021-11-23T02:31:40Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030000",
      "lbl" : "choroidal melanocyte",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A melanocyte located in the vascular uvea and involved in photoprotection, regulation of oxidative damage and immune responses.",
          "xrefs" : [ "PMID:31819095", "http://orcid.org/0000-0002-0819-0473" ]
        },
        "comments" : [ "Cellular functions and extracellular interactions of choroidal melanocytes are distinct to skin melanocytes. They might have both neuroectodermal as well as mesectodermal origins." ],
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          "pred" : "hasExactSynonym",
          "val" : "uveal melanocyte"
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          "val" : "2022-01-20T12:59:06Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030001",
      "lbl" : "stromal cell of thymus",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A stromal cell that is part of the thymus.",
          "xrefs" : [ "doi:10.1038/s41467-020-20082-7" ]
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          "val" : "thymic stromal cell"
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          "val" : "2022-07-08T11:39:38Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030008",
      "lbl" : "pronephric podocyte",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A specialized epithelial cell that contains \"feet\" that interdigitate with the \"feet\" of other glomerular epithelial cells in the pronephros.",
          "xrefs" : [ "PMID:10322630" ]
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          "val" : "pronephric glomerular visceral epithelial cell",
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          "val" : "2022-03-11T14:38:32Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030011",
      "lbl" : "epithelial cell of proximal tubule segment 3",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A brush border cell that is part of segment 3 (S3) of the proximal tubule epithelium, which extends from the medullary rays of the renal cortex into the outer medulla.",
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      "lbl" : "renal medullary fibroblast",
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        "definition" : {
          "val" : "A fibroblast that is located in the renal medulla interstitium.",
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      "lbl" : "renal cortical fibroblast",
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        "definition" : {
          "val" : "A fibroblast that is located in the renal cortical interstitium.",
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        "comments" : [ "Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix and maintenance of renal tissue architecture. They additionally have an endocrine function in the production of epoetin." ],
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      "lbl" : "GABAergic amacrine cell",
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        "definition" : {
          "val" : "An amacrine cell that uses GABA as a neurotransmitter.",
          "xrefs" : [ "https://doi.org/10.1016/j.cell.2020.08.013" ]
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          "val" : "2022-10-17T12:35:11Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030029",
      "lbl" : "blood lymphocyte",
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        "definition" : {
          "val" : "A lymphocyte located in blood.",
          "xrefs" : [ "https://orcid.org/0000-0001-9990-8331" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#blood_and_immune_upper_slim" ],
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          "val" : "2022-11-04T14:40:00Z"
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      "id" : "http://purl.obolibrary.org/obo/CL_4030031",
      "lbl" : "interstitial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any cell that is located within the interstitium between the cells most prominent in defining a given tissue. \"Interstitial cell\" is a morphological term and refers to a variety of cells with differing origins and phenotypes.",
          "xrefs" : [ "PMID:24987007" ]
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        "basicPropertyValues" : [ {
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      "lbl" : "valve interstitial cell",
      "type" : "CLASS",
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        "definition" : {
          "val" : "An interstitial cell that is part of a cardiac valve leaflet. Along with valve endothelial cells, a valve interstitial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.",
          "xrefs" : [ "https://orcid.org/0000-0001-7655-4833", "PMID:25311230", "https://doi.org/10.1098/rsif.2017.0580", "https://doi.org/10.1161/ATVBAHA.120.314789", "https://doi.org/10.1161/JAHA.117.006339", "https://doi.org/10.2353/ajpath.2007.070251" ]
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        "comments" : [ "Activated valve interstitial cells undergo continual turn over into deactivated fibroblasts and other cell fates (such as apoptosis)." ],
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          "val" : "cardiac valve interstitial cell"
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      "lbl" : "valve endothelial cell",
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          "val" : "An endothelial cell that lines a surface of a cardiac valve leaflet. Along with valve interstitial cells, a valve endothelial cell maintains tissue homeostasis for the function of cardiac valves through secreting biochemical signals, matrix proteins and matrix remodeling enzymes.",
          "xrefs" : [ "PMID:25311230" ]
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      "id" : "http://purl.obolibrary.org/obo/CL_4030034",
      "lbl" : "respiratory tract multiciliated cell",
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          "val" : "A multiciliated epithelial cell located in the respiratory tract epithelium, characterized by a columnar shape and motile cilia on its apical surface. This cell develops through a highly orchestrated process, transitioning from a basal progenitor via an intermediate deuterosomal cell stage that generates centrioles essential for ciliogenesis.",
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          "val" : "ciliated cell of the respiratory tract"
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      "lbl" : "dental pulp stem cell",
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        "definition" : {
          "val" : "A dental pulp cell that possesses stem-cell-like qualities, including self-renewal capability and multi-lineage differentiation.",
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      "lbl" : "early spermatid",
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      "lbl" : "late spermatid",
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      "lbl" : "ureteric bud cell",
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        "definition" : {
          "val" : "An epithelial cell that is part of a ureteric bud. A ureteric bud cell has the potential to induce metanephric mesenchymal cells to proliferate and convert to epithelia that form renal tubules via: (1) the secretion of multiple diffusible growth factors that rescue renal progenitors from apoptosis and stimulate them to proliferate and (2) contact-dependent mechanisms that induce mesenchymal-epithelial conversion.",
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      "lbl" : "endothelial cell of venule of lymph node",
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        "definition" : {
          "val" : "A(n) endothelial cell that is part of a(n) venule of lymph node.",
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      "lbl" : "endothelial cell of arteriole of lymph node",
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        "definition" : {
          "val" : "A(n) endothelial cell that is part of a(n) arteriole of lymph node.",
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      "lbl" : "neuroendocrine cell of epithelium of crypt of Lieberkuhn",
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        "definition" : {
          "val" : "A(n) neuroendocrine cell that is part of a(n) epithelium of crypt of Lieberkuhn.",
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      "id" : "http://purl.obolibrary.org/obo/CL_4033003",
      "lbl" : "myoepithelial cell of bronchus submucosal gland",
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      "id" : "http://purl.obolibrary.org/obo/CL_4033005",
      "lbl" : "serous secreting cell of bronchus submucosal gland",
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      "lbl" : "endothelial cell of efferent lymphatic vessel",
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        "definition" : {
          "val" : "A(n) endothelial cell that is part of a(n) efferent lymphatic vessel.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033007",
      "lbl" : "brush cell of epithelium of lobar bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) brush cell that is part of a(n) epithelium of lobar bronchus.",
          "xrefs" : [ "PMID:15817800" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033008",
      "lbl" : "vein endothelial cell of respiratory system",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) vein endothelial cell that is part of a(n) respiratory system.",
          "xrefs" : [ "PMID:34030460" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033009",
      "lbl" : "goblet cell of epithelium of lobar bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) goblet cell that is part of a(n) epithelium of lobar bronchus.",
          "xrefs" : [ "PMID:18757316" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033010",
      "lbl" : "neuroendocrine cell of epithelium of lobar bronchus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) neuroendocrine cell that is part of a(n) epithelium of lobar bronchus.",
          "xrefs" : [ "PMID:26711336", "PMID:33355253" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033011",
      "lbl" : "smooth muscle cell of large intestine smooth muscle circular layer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle circular layer.",
          "xrefs" : [ "PMID:24997029" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033012",
      "lbl" : "smooth muscle cell of large intestine smooth muscle longitudinal layer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A(n) smooth muscle cell that is part of a(n) large intestine smooth muscle longitudinal layer.",
          "xrefs" : [ "PMID:24997029" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033013",
      "lbl" : "suprabasal keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A keratinocyte that resides in the epidermal suprabasal layer and expresses differentiation markers, including keratin 1 and keratin 10, in both humans and mice. In human interfollicular epidermis, this cell retains proliferative capacity and possesses retrodifferentiation potential, acquiring basal-like properties during wound healing or basement membrane contact.",
          "xrefs" : [ "PMID:22375063", "PMID:35883599", "PMID:9520465", "https://www.proteinatlas.org/humanproteome/single+cell+type/squamous+epithelial+cells#suprabasalkeratinocytes" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2023-02-02T11:17:04Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033015",
      "lbl" : "retinal astrocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A star-shaped glial cell that is part of some retina. This cell links neurons to blood vessels and may provide structural and physiological support to optic nerve head axons.",
          "xrefs" : [ "PMID:25236977", "PMID:33796062" ]
        },
        "comments" : [ "In response to elevated intraocular pressure, a retinal astrocyte may modulate extracellular matrix remodeling. In the human retina, a retinal astrocyte is GFAP-positive, SOD3-positive and GYPC-positive." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/cl#eye_upper_slim" ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-02T14:38:32Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033017",
      "lbl" : "bronchiolar smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of a bronchiole.",
          "xrefs" : [ "ISBN:9781260462982", "PMID:15347627" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-16T09:38:17Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033018",
      "lbl" : "lung megakaryocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A megakaryocyte that is resident in the lung connective tissue.",
          "xrefs" : [ "PMID:33351116" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lung resident megakaryocyte",
          "xrefs" : [ "PMID:36524131" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lung-resident megakaryocyte",
          "xrefs" : [ "PMID:36524131" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-16T11:31:23Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033020",
      "lbl" : "mucus secreting cell of trachea gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mucus secreting cell that is part of a submucosal gland of the trachea.",
          "xrefs" : [ "PMID:18931053", "PMID:29656943" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "tracheal submucosal gland mucous cell",
          "xrefs" : [ "PMID:18931053" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0001-6677-8489"
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          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-16T13:03:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033021",
      "lbl" : "myoepithelial cell of trachea gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A myoepithelial cell that is part of a submucosal gland of the trachea.",
          "xrefs" : [ "PMID:29656943" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-16T13:36:43Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033022",
      "lbl" : "mucus secreting cell of bronchus submucosal gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mucus secreting cell of a submucosal gland of the bronchus.",
          "xrefs" : [ "PMID:19965983" ]
        },
        "comments" : [ "The marker set BPIFB2 can identify the Human cell type mucus secreting cell of bronchus submucosal gland in the lung with a confidence of 0.93 (NS-Forest FBeta value)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "bronchial gland mucous cell",
          "xrefs" : [ "PMID:5487122" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-03-16T15:12:52Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033037",
      "lbl" : "mucus secreting cell of tracheobronchial tree submucosal gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mucus secreting cell of a submucosal gland of the tracheobronchial tree.",
          "xrefs" : [ "PMID:30864819" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2023-04-20T10:55:50Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033044",
      "lbl" : "deuterosomal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell part of respiratory tract epithelium that is a precursor of a multi-ciliated cell. This cell actively amplifies centrioles, a required step for multiciliogenesis.",
          "xrefs" : [ "PMID:31558434", "PMID:331922198", "PMID:36883528", "PMID:37291214" ]
        },
        "comments" : [ "In humans, deuterosomal cells have been noted to have enriched expression of the following: PLK4, FOXJ1, DEUP1, FOXN4, YPEL1, HES6 and CDC20B. Deuterosomal cells were termed after deuterosomes, the platforms of active centriole amplification." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset", "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-9185-3994"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-06-20T10:27:17Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033049",
      "lbl" : "taste receptor cell of tongue",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A taste receptor cell that is part of a taste bud of a tongue.",
          "xrefs" : [ "DOI:10.1111/j.1096-3642.1981.tb01137.x", "PMID:10052456", "PMID:28655883", "http://www.nejohnston.org/Birds/documents/AvianTongues_Johnston.pdf" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "gustatory cell of tongue",
          "xrefs" : [ "DOI:10.1016/s0022-5320(69)80043-2" ]
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        "basicPropertyValues" : [ {
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-05-03T07:59:58Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033050",
      "lbl" : "catecholaminergic neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron that releases catecholamine as a neurotransmitter.",
          "xrefs" : [ "ISBN:0521442516", "PMID:12094209" ]
        },
        "comments" : [ "Frequently used when describing the developing nervous system in zebrafish. A catecholaminergic neuron expresses tyrosine hydroxylase (TH), tyrosine hydroxylase 2 (TH2), aromatic amino acid decarboxylase (AADC), dopamine b-hydroxylase (DBH), and phenylethanolamine-N-methyl transferase (PEMT), which are enzymes necessary for catecholamine synthesis." ],
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-05-18T12:07:45Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033054",
      "lbl" : "perivascular cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell that is adjacent to a vessel. A perivascular cell plays a crucial role in maintaining vascular function and tissue homeostasis. This cell type regulates vessel integrity and flow dynamics.",
          "xrefs" : [ "PMID:24928499", "PMID:27889329" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "basicPropertyValues" : [ {
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          "val" : "2023-08-22T13:40:28Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033057",
      "lbl" : "luminal adaptive secretory precursor cell of mammary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A luminal epithelial cell of the mammary gland that can proliferate and has the potential to differentiate into a lactocyte during pregnancy. In humans, a luminal adaptive secretory precursor cell can be identified by high levels of the markers EpCAM and CD49f, and in mice it can be identified by low levels of CD29 and high levels of CD14, Kit, CD61, and Tspan8.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "alveolar cell",
          "xrefs" : [ "PMID:35617956" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "alveolar progenitor",
          "xrefs" : [ "PMID:26390871" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "luminal progenitor",
          "xrefs" : [ "doi:10.1101/2023.04.21.537845" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "luminal progenitor cell",
          "xrefs" : [ "PMID:20346151" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "luminal secretory cell",
          "xrefs" : [ "PMID:37380767" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ER-negative luminal alveolar progenitor",
          "xrefs" : [ "https://nrs.harvard.edu/URN-3:HUL.INSTREPOS:37368328" ]
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          "val" : "https://orcid.org/0000-0003-4969-670X"
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          "val" : "2023-10-13T13:02:55Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033061",
      "lbl" : "endothelial cell of central vein of liver",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An endothelial cell that is part of a central vein of liver.",
          "xrefs" : [ "PMID:28287163" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "endothelial cell of central vein",
          "xrefs" : [ "PMID:28287163" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033064",
      "lbl" : "uterine resident macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage that is part of the uterus.",
          "xrefs" : [ "PMID:36113384" ]
        },
        "comments" : [ "Uterine macrophages are reported to be evenly distributed throughout the endometrial stroma but with aggregations observed close to the lumen of superficial secretory glands." ],
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        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "uterine macrophage",
          "xrefs" : [ "PMID:36113384" ]
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          "val" : "2024-01-08T16:05:09Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033066",
      "lbl" : "pre-granulosa cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supporting cell that is part of the ovary and differentiates into a granulosa cell. A pre-granulosa cell develops from an early supporting gonadal cell by repressing testis determination, which can then proliferate to form primordial follicles.",
          "xrefs" : [ "PMID:17639032", "PMID:32759216", "PMID:33970370", "PMID:38178246" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ovarian pregranulosa cell",
          "xrefs" : [ "PMID:32759216" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pregranulosa cell",
          "xrefs" : [ "PMID:17639032", "PMID:32759216" ]
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          "val" : "https://orcid.org/0000-0001-7655-4833"
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          "val" : "2024-06-07T12:04:57Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033083",
      "lbl" : "squamous granulosa cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granulosa cell that has a squamous morphology and form a single layer around the oocyte in primordial follicles. This cell develops directly into a cuboidal granulosa cell during the primordial-to-primary follicle transition.",
          "xrefs" : [ "PMID:28892263" ]
        },
        "comments" : [ "Often in literature squamous granulosa cell and pre-granulosa cell are used as synonyms. However, this term only makes reference to the quiescent granulosa cells that surround the primordial ovarian follicle, while a pre-granulosa cell proliferates to form the primordial follicle (and thus cells become the squamous granulosa cells)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "flattened granulosa cell",
          "xrefs" : [ "PMID:22402964" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pre-granulosa cell",
          "xrefs" : [ "PMID:33914868" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0001-6677-8489"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-24T13:13:24Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033084",
      "lbl" : "cuboidal granulosa cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A granulosa cell that has a cuboidal morphology and develops from squamous granulosa cell during the transition between primordial follicle to primary follicle. Cuboidal granulosa cells proliferate to form a second layer within secondary follicles.",
          "xrefs" : [ "PMID:28892263" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "columnar granulosa cell",
          "xrefs" : [ "PMID:19001500" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cuboidal epithelial granulosa cell",
          "xrefs" : [ "PMID:31849844" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-6677-8489"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-24T13:14:57Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033087",
      "lbl" : "placental resident macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tissue-resident macrophage that is part of the placenta. This cell helps preventing immunological rejection of the fetus by modulating the immune environment. A placental resident macrophage has high plasticity to adapt to the changing needs of each phase of pregnancy.",
          "xrefs" : [ "PMID:39007150" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "placental macrophage",
          "xrefs" : [ "PMID:39007150" ]
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-7655-4833"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-10-31T10:24:21Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033093",
      "lbl" : "limbal epithelial stem cell of cornea",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stem cell that is part of the corneo-scleral limbus. This cell type resides at the basal layer of the epithelium and has a small size and high nuclear to cytoplasmatic ratio (Secker and Daniels, 2009). A limbal stem cell is responsible for corneal epithelial renewal and repair (Li et al., 2023), and to help maintain a clear corneal surface by preventing conjunctival epithelial cells from migrating onto the cornea (Wang et al., 2023).",
          "xrefs" : [ "PMID:20614614", "PMID:29105366", "PMID:36983561", "PMID:37768272" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "limbal epithelial stem cell",
          "xrefs" : [ "PMID:20614614" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "limbal stem cell",
          "xrefs" : [ "PMID:17562792" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0001-6677-8489"
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          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-7655-4833"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-12-11T13:59:19Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4033097",
      "lbl" : "Schlemm's canal endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialised endothelial cell that is part of the canal of Schlemm. This cell type shares characteristics and expresses markers of both blood and lymphatic endothelial cells (Kizhatil et al., 2014) and regulates aqueous humor outflow resistance by modulating pore formation and responding to mechanical strain (Stamer et al., 2015).",
          "xrefs" : [ "PMID:25051267", "PMID:25223880" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0001-6677-8489"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2025-06-16T13:55:29Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4040002",
      "lbl" : "enteroglial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Glial cell that provides support to the enteric nervous system. It is involved in enteric neurotransmission, in maintaining the integrity of the mucosal barrier of the gut and serves as a link between the nervous and immune systems of the gut. In enteric nerve strands, glial processes ensheath multiaxonal bundles which distinguishes enteric glia from all other peripheral glia. Ultrastructurally, the most conspicuous trait of an enteroglial cell is the presence of 10 nm filaments, which criss-cross the cell body, form axial bundles in the processes and appear to firmly anchor the cells to the ganglionic surfaces. Similar to astrocytes, their main constituent is glial fibrillary acidic protein (GFAP).",
          "xrefs" : [ "PMID:16336493", "PMID:17483847", "PMID:25975510" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "enteric glial cell",
          "xrefs" : [ "PMID:11169131", "PMID:25170211" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-0819-0473"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-04-03T15:15:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4040003",
      "lbl" : "fetal pre-type II pulmonary alveolar epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Precursor of type II pneumocyte. These cells do not have lamellar bodies, which are a marker of type II pneumocyte maturity.",
          "xrefs" : [ "PMID:1316350" ]
        },
        "comments" : [ "According to PMID:1316350 this cell type does not yet produce surfactant. According to PMID:9109447 and PMID:12114192 this cell type produces low levels of surfactant that can be increased by administration of very low-density lipoproteins. This cell type is of medical relevance, as a central feature of the fetal respiratory distress syndrome seems to be the presence in the lung of abundant pre-type II alveolar epithelial cells (PMID:1316350)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/cl#cellxgene_subset" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "fetal alveolar pre-type II epithelial cell",
          "xrefs" : [ "PMID:9624168" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fetal pre-type 2 pneumocyte",
          "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fetal pre-type II alveolar epithelial cell",
          "xrefs" : [ "PMID:12114192" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fetal pre-type II pneumocyte"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-0819-0473"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-06-02T09:19:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4040004",
      "lbl" : "mesenchymal stem cell of orbital adipose tissue",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any mesenchymal stem cell of adipose tissue that is part of an orbital region.",
          "xrefs" : [ "https://orcid.org/0000-0002-0819-0473" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "OAMSC",
          "xrefs" : [ "PMID:31377878" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Orbital ASCs",
          "xrefs" : [ "PMID:30210548" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "orbital adipose-derived mesenchymal stem cell",
          "xrefs" : [ "PMID:31377878" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-0819-0473"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2023-09-18T10:43:00Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4042003",
      "lbl" : "border associated macrophage",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A central nervous system macrophage that is part of a choroid plexus, a meninx and a perivascular space. A border associated macrophage interacts with various components of the CNS vasculature and meninges, it participates in immune surveillance and in the regulation of the blood brain barrier.",
          "xrefs" : [ "PMID:37232741", "PMID:37626977" ]
        },
        "comments" : [ "In humans, a border associate macrophage expresses CD45 and CD11B. This cell is also known to have the following molecular signature: CD206, CD38, LYVE1, CD163, CD169." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "CNS-associated macrophage",
          "xrefs" : [ "PMID:37232741" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0000-0002-0098-8958"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-03-26T16:39:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4042035",
      "lbl" : "molecular layer interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of cerebellar inhibitory GABAergic interneuron that is located in the molecular layer of the cerebellum. This cell type inhibits Purkinje cells and other molecular layer interneurons. This interneuron plays a crucial role in regulating cerebellar output through feedforward inhibition and is characterized by its fast-spiking properties.",
          "xrefs" : [ "PMID:30742002", "PMID:33075461", "PMID:34616064", "PMID:38692278" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "MLI",
          "xrefs" : [ "PMID:33075461" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0002-0098-8958"
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-10-31T15:55:31Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4042039",
      "lbl" : "caudal ganglionic eminence derived neuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A neuron of the central nervous system that develops from a caudal ganglionic eminence.",
          "xrefs" : [ "PMID:12593982", "PMID:12637172", "PMID:20130169", "https://www.ncbi.nlm.nih.gov/books/NBK98190/" ]
        },
        "comments" : [ "Neurons derived from the caudal ganglionic eminence consist mostly of neurons populating the cortical layers of the brain and some subcortical areas such as the globus pallidus, the striatus and the hippocampus. Amongst neurons derived from the caudal ganglionic eminence there are cortical GABAergic neurons such as Pax6, Lamp5, VIP, sncg, GABAergic; in the hippocampus, mossy fibers, pyramidal neurons, granule neurons and interneurons; in the striatum and globus pallidus, medium spiny projection neurons." ],
        "basicPropertyValues" : [ {
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-11-14T11:27:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047017",
      "lbl" : "transit amplifying cell of gut",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A transit amplifying cell of the gut epithelium, located in the wall of the intestinal crypt, just above intestinal stem cells from which they derive. These are rapidly dividing cells, capable of multiple rounds of division before differentiating into the various cell types of the gut epithelium (enterocyte, goblet, eneterodendocrine, paneth cells).",
          "xrefs" : [ "PMID:20683682", "PMID:33195268", "PMID:34497389" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "transit-amplifying cell",
          "xrefs" : [ "PMID:24813615" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TA cell",
          "xrefs" : [ "PMID:20683682" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0005-7919-4905"
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-24T10:48:47Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047023",
      "lbl" : "intestinal lamina propria fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast located in the lamina propria of the intestinal mucosa. This cell expresses PDGFRα and CD81 and is negative for α-smooth muscle actin (α-SMA). This cell is predominantly located in the small intestine adjacent to myofibroblasts surrounding the crypts. It is capable of synthesizing extracellular matrix components and structural proteins such as collagen and elastin.",
          "xrefs" : [ "PMID:21252048", "PMID:36032088" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "S1 fibroblast",
          "xrefs" : [ "PMID:30270042" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0005-7919-4905"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-24T15:45:18Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047025",
      "lbl" : "type G cell of stomach",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any type G enteroendocrine cell that is part of some epithelium of stomach.",
          "xrefs" : [ "FBC:Autogenerated" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2024-10-24T10:43:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047034",
      "lbl" : "smooth muscle cell of stomach",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the muscularis externa of the stomach wall. It is characterized by its fusiform shape, involuntary control, and ability to generate slow, sustained contractions. This cell is organized in distinct layers and is essential for gastric motility and digestion.",
          "xrefs" : [ "PMID:21443757", "PMID:33630273" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2024-12-05T11:10:18Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047036",
      "lbl" : "stomach smooth muscle circular layer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell located in the middle layer of the muscularis externa of the stomach wall. This cell is arranged concentrically with the stomach's longitudinal axis, forming a continuous sheet of contractile tissue. It is fusiform in shape, containing actin and myosin filaments that enable contraction without striations. This cell contributes to the mechanical digestion and movement of food within the stomach through coordinated contractions, and plays a role in forming the pyloric sphincter in the pyloric region.",
          "xrefs" : [ "PMID:11146428", "PMID:32424507" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2024-12-09T10:40:58Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047037",
      "lbl" : "stomach smooth muscle inner oblique layer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell found in the innermost layer of the muscularis externa of the stomach wall. This cell forms a unique layer of smooth muscle fibers oriented obliquely to the stomach's longitudinal axis. It is responsible for aiding in the mixing and churning of gastric contents, contributing to mechanical digestion within the stomach.",
          "xrefs" : [ "PMID:29493959" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "stomach smooth muscle oblique layer cell"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2024-12-09T10:53:19Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4047101",
      "lbl" : "liver-resident natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell resident to the liver, located in the hepatic sinusoids. In humans this cell type is distinguished from circulating natural killer cells by CD49a or CD69 gene expression. Liver-resident natural killer cells have also been shown to express CCR5, EOMES, KLRB1, GZMK, and CXCR6 in humans.",
          "xrefs" : [ "PMID:26330348", "PMID:26639736", "PMID:27798170", "PMID:31114585", "PMID:32351704", "PMID:34230995", "PMID:35865550" ]
        },
        "comments" : [ "Liver-resident natural killer cells play a crucial role in modulating the immune response during inflammation by balancing cytotoxic activity and cytokine production, thereby contributing to the maintenance of liver homeostasis and protection against excessive tissue damage." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "he-NK",
          "xrefs" : [ "PMID:31114585" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hepatic NK",
          "xrefs" : [ "doi:10.3389/fimmu.2019.00946" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "hepatic natural killer cells",
          "xrefs" : [ "doi:10.3389/fimmu.2019.00946" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intrahepatic NK",
          "xrefs" : [ "PMID:33828559" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver NK cell",
          "xrefs" : [ "PMID:26639736" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver resident natural killer cell",
          "xrefs" : [ "PMID:26330348" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "liver-specific natural killer cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lr-NK",
          "xrefs" : [ "PMID:35726345" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0001-8134-3037"
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          "val" : "2024-07-29T13:43:11Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052001",
      "lbl" : "multiciliated ependymal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An ependymal cell that lines the lateral, third, and fourth ventricles of the brain. The cell is characterized by multiple motile cilia on its apical surface, which beats in a coordinated manner to facilitate the movement of cerebrospinal fluid (CSF), contributing to brain homeostasis.",
          "xrefs" : [ "PMID:25045600", "PMID:28067220", "PMID:37008045" ]
        },
        "comments" : [ "multiciliated ependymal cell, with an average of 16 motile cilia per cell, exhibits two types of planar cell polarity (PCP): rotational polarity, with unidirectional cilia orientation, and translational polarity, with asymmetric cilia positioning in the apical area. This location-specific PCP varies across the ventricular wall, aligning with the direction of CSF flow. These cells are interconnected by adherens and gap junctions, which support intercellular communication and maintain the structural integrity of the ependymal layer. Unlike some other cell types, these cells lack tight junctions." ],
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          "pred" : "hasBroadSynonym",
          "val" : "multiciliated ependymal cells",
          "xrefs" : [ "PMID:25045600" ]
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          "val" : "2024-08-20T10:06:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052002",
      "lbl" : "syncytial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A multinucleate cell formed by the fusion of multiple uninuclear cells through plasma membrane fusion. This process leads to a single large cell containing multiple nuclei within a shared cytoplasm.",
          "xrefs" : [ "PMID:20851884", "Wikipedia:Syncytium" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "syncytium",
          "xrefs" : [ "WBbt:0008074" ]
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          "val" : "2024-08-15T10:38:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052003",
      "lbl" : "intestinal villus capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A capillary endothelial cell that is part of the intestinal villus. This cell is highly fenestrated, with fenestrations most numerous at the villus tips, and plays a vital role in nutrient absorption and maintaining the selective permeability of the intestinal barrier.",
          "xrefs" : [ "PMID:18480313", "PMID:35810168", "PMID:38051275" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "villus blood capillary endothelial cells",
          "xrefs" : [ "PMID:35810168" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "villus tip endothelial cell",
          "xrefs" : [ "PMID:38051275" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-17T10:03:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052006",
      "lbl" : "intestinal enteroendocrine progenitor",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the crypt of Lieberkuhn, originating from intestinal stem cells and giving rise to enteroendocrine cells (EECs). In mouse and human, this cell can be characterized by the expression of Neurog3, and has the ability to proliferate and differentiate into multiple EEC subtypes. Its proliferative potential contributes to crypt growth, distinguishing it from fully differentiated EECs.",
          "xrefs" : [ "PMID:31756561", "PMID:32531023", "PMID:35913117", "PMID:38260422", "doi:/10.1038/s41467-021-27901-5" ]
        },
        "comments" : [ "The EEC progenitor is also present in other organisms; for example, flies have EEC progenitors but lack intestinal crypts and do not express the same markers. Instead, they are Dl+ and Pros+." ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-20T12:13:26Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052010",
      "lbl" : "pre-theca cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell that serves as a precursor to the theca cell layers in the ovary growing follicles. This cell is present in the early stages of follicular growth, particularly in smaller follicles. Unlike mature theca cell, a pre-theca cell is initially non-steroidogenic and lacks luteinizing hormone receptors.",
          "xrefs" : [ "PMID:20628033", "PMID:31320652", "PMID:36205477" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "early theca cell",
          "xrefs" : [ "PMID:36205477" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "progenitor theca cell",
          "xrefs" : [ "PMID:31320652" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-25T11:15:57Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052012",
      "lbl" : "interna theca cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized theca cell that forms the inner, highly vascularized layer of the theca surrounding ovarian follicles. Originating from progenitor theca cells, the theca interna cell is steroidogenic, playing a crucial role in the production of androgens, which serves as a precursor for estrogen synthesis in granulosa cells. This cell expresses luteinizing hormone receptors, enabling it to respond to hormonal signals that regulate steroidogenesis.",
          "xrefs" : [ "PMID:15833266", "PMID:31320652", "PMID:32530882", "Wikipedia:Theca_interna" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "androgenic theca cell",
          "xrefs" : [ "PMID:36599970" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "steroidogenic theca interna cell",
          "xrefs" : [ "PMID:36599970" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-30T11:10:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052013",
      "lbl" : "externa theca cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized theca cell that forms the outer layer of the theca surrounding the ovarian follicle, appearing at the antral follicle. Originating from progenitor theca cells, theca externa cell is characterized by its fibroblast-like appearance and primarily function to provide structural support to the developing follicle. This cell produces collagen fibers and extracellular matrix components such as Col1a1 and Col1a2.",
          "xrefs" : [ "PMID:31320652", "PMID:32530882", "PMID:36758341", "Wikipedia:Theca_externa" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "structural theca cell",
          "xrefs" : [ "PMID:36599970" ]
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-30T11:10:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052014",
      "lbl" : "pancreatic islet capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A capillary endothelial cell that is part of islet of Langerhans, characterized by a high density of fenestrations —approximately ten times greater than those in exocrine pancreatic capillaries. These fenestrations facilitate efficient hormone exchange, which is essential for maintaining glucose homeostasis. The cell's structure and function are regulated by the local production of vascular endothelial growth factor-A (VEGF-A), which maintains its fenestrated architecture.",
          "xrefs" : [ "PMID:16607697", "PMID:27124642", "PMID:28396983", "PMID:33200981" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "islet endothelial cell",
          "xrefs" : [ "PMID:16607697", "PMID:28396983" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "pancreatic islet endothelial cell",
          "xrefs" : [ "PMID:16607697" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-30T14:36:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052015",
      "lbl" : "endocrine gland capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any capillary endothelial cell that is part of an endocrine gland.",
          "xrefs" : [ "PMID:18480313" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-30T15:27:49Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052016",
      "lbl" : "pituitary gland capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A capillary endothelial cell that is part of the pituitary gland. This cell is characterized by its fenestrated structure which facilitates the efficient transport of hormones and other signaling molecules, essential for endocrine signalling.",
          "xrefs" : [ "PMID:10810312", "PMID:32910242" ]
        },
        "comments" : [ "In the anterior pituitary gland of rats, capillary endothelial cells are distinguished by numerous fenestrations, which are covered by a single-layered diaphragm. The diaphragm features a dense ring-like structure." ],
        "basicPropertyValues" : [ {
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        }, {
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          "val" : "2024-09-30T15:31:45Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052017",
      "lbl" : "choroid plexus capillary endothelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A capillary endothelial cell that is part of the choroid plexus, characterized by its fenestrated nature with 60 to 80 nm fenestrations and lack of tight junctions. This fenestrated structure allows for the rapid delivery of water and other components, aiding in the production of cerebrospinal fluid (CSF).",
          "xrefs" : [ "PMID:18480313", "PMID:32375819", "https://www.ncbi.nlm.nih.gov/books/NBK27998/" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
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        }, {
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          "val" : "2024-10-01T11:38:22Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052018",
      "lbl" : "fallopian tube epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any epithelial cell that is part of the fallopian tube.",
          "xrefs" : [ "Wikipedia:Fallopian_tube" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "oviduct epithelial cell",
          "xrefs" : [ "Wikipedia:Fallopian_tube" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "uterine tube epithelial cell",
          "xrefs" : [ "Wikipedia:Fallopian_tube" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-10-01T12:09:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052022",
      "lbl" : "fallopian tube smooth muscle cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A smooth muscle cell that is part of the fallopian tube. This cell is responsible for peristaltic contractions that facilitate gamete and embryo transport, fluid mixing, and embryo admission to the uterus.",
          "xrefs" : [ "PMID:31183831", "PMID:31613440" ]
        },
        "comments" : [ "The fallopian tube smooth muscle cell in the human contracts dynamically in response to hormones and signaling molecules. Prostaglandins, particularly PGF2α and PGE2, have been shown to increase muscular contractions, while progesterone, levonorgestrel, mifepristone, oxytocin, and human chorionic gonadotropin (hCG) decrease them. These contractile responses are crucial for regulating gamete and embryo transport through the fallopian tube." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "oviduct smooth muscle cell",
          "xrefs" : [ "PMID:31613440" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "uterine tube smooth muscle cell",
          "xrefs" : [ "PMID:31613440" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.org/dc/terms/contributor",
          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-10-21T12:16:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052023",
      "lbl" : "luminal endometrial unciliated epithelial cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of the endometrial luminal epithelium, forming a continuous layer lining the uterine cavity. This cell undergoes cyclical changes during the menstrual cycle, proliferating under estrogen in the proliferative phase, and differentiating under progesterone in the secretory phase to prepare for potential implantation. During the window of implantation, this cell changes from a tall columnar shape to a shorter columnar or cuboidal form, loses polarity, and becomes receptive to blastocyst implantation.",
          "xrefs" : [ "PMID:32929266", "PMID:36581776", "PMID:38559249", "PMID:39198675" ]
        },
        "comments" : [ "The luminal endometrial unciliated epithelial cell expresses WNT7A, and LGR5 during the proliferative phase, transitioning to express VTCN1 and SULT1E1 in the early secretory phase, and LEFTY1, IL6, and PTGS1 in the mid- to late-secretory phases." ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-10-22T12:02:23Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052028",
      "lbl" : "uterine natural killer cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A natural killer cell that is part of the uterus, specifically within the endometrium during the non-pregnant state and in the decidua during pregnancy. This cell exhibits dynamic changes in frequency throughout the menstrual cycle, with lower levels during menstruation and a significant increase during the mid-secretory phase and early pregnancy.",
          "xrefs" : [ "PMID:35720413", "PMID:39198675", "Wikipedia:Uterine_natural_killer_cells" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/uberon/core#human_reference_atlas" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "endometrial natural killer cell",
          "xrefs" : [ "PMID:35720413" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-11-15T10:12:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052030",
      "lbl" : "adventitial fibroblast",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A fibroblast of the adventitia of a blood vessel. This cell contributes to vascular homeostasis, remodeling, and inflammation by producing extracellular matrix components, cytokines, and growth factors. Adventitial fibroblast can transition into an activated state during injury or disease, marked by increased proliferation, migration, matrix deposition, and contractile protein expression",
          "xrefs" : [ "PMID:28705796", "PMID:36718802" ]
        },
        "comments" : [ "Single-cell transcriptomics of murine aorta identifies two adventitial fibroblast-specific markers, PDGFRA and DPEP1, which were validated at the protein level by immunohistochemistry and flow cytometry across human and murine arteries, highlighting fibroblast heterogeneity in health and cardiovascular disease (CVD) in humans and mice." ],
        "basicPropertyValues" : [ {
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-12-05T11:01:15Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052034",
      "lbl" : "tuft cell of thymus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers, including L1CAM in both mice (Zhang et al., 2022) and humans (Sun et al., 2023), as well as MHC II in mice (Miller et al., 2018). This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. A tuft cell in the thymus exhibits characteristics of both a medullary thymic epithelial cell (mTEC) and a peripheral tuft cell. Its development is governed by transcription factors such as POU2F3.",
          "xrefs" : [ "PMID:30022164", "PMID:30904566", "PMID:35668088", "PMID:36351364", "PMID:36961668" ]
        },
        "comments" : [ "A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "thymic tuft cell",
          "xrefs" : [ "PMID:30904566" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0009-0000-8480-9277"
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          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2025-01-16T11:29:54Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052035",
      "lbl" : "tuft cell of pancreatic duct",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of pancreatic duct. Present in humans and rats, this cell is absent in the murine pancreas under normal conditions but emerges during acinar-to-ductal metaplasia triggered by injury, inflammation, or oncogenic mutations. It modulates the immune response and protects against pancreatic ductal adenocarcinoma progression by producing suppressive eicosanoids, such as prostaglandin D2. A tuft cell in the pancreatic duct highly expresses the transcription factor POU2F3, which is essential for its development and presence.",
          "xrefs" : [ "PMID:30904566", "PMID:32717220" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic brush cell",
          "xrefs" : [ "PMID:9749964" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pancreatic tuft cell",
          "xrefs" : [ "PMID:32717220" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2025-01-16T11:50:08Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052036",
      "lbl" : "tuft cell of nasal cavity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the nasal cavity epithelium, located in both the respiratory and olfactory epithelia of the nose. This cell plays key roles in chemosensation, lipid mediator production, immune responses, and epithelial homeostasis.",
          "xrefs" : [ "PMID:30379593", "PMID:38306414" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nasal brush cell",
          "xrefs" : [ "PMID:34692913" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "nasal tuft cell",
          "xrefs" : [ "PMID:38306414" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2025-01-21T09:04:03Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052037",
      "lbl" : "tuft cell of olfactory epithelium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the olfactory epithelium, characterized by a globular body and the expression of neurogranin (Nrgn) in mice. This cell plays a crucial role in allergen recognition and regulating olfactory stem cell proliferation via TRPM5-dependent ATP sensing and cysteinyl leukotriene production. Unlike nasal respiratory tuft cells, it has low to absent expression of taste receptors, including the G protein Gα gustducin, and rarely contacts olfactory sensory neurons directly.",
          "xrefs" : [ "PMID:38306414", "doi:/10.1101/2022.09.26.509561" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "olfactory tuft cell",
          "xrefs" : [ "PMID:38306414" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TPRM5+ tuft-MVC",
          "xrefs" : [ "PMID:38306414" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TRPM5+ microvillous cell",
          "xrefs" : [ "PMID:38306414" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TRPM5+ microvillous tuft cell",
          "xrefs" : [ "doi:/10.1101/2022.09.26.509561" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tuft-microvillous cell",
          "xrefs" : [ "PMID:38306414" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2025-02-06T15:03:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052039",
      "lbl" : "tuft cell of submandibular gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of the submandibular gland, localized to the striated ducts in mice, pigs, and humans, and to the main excretory ducts in rats. This cell is characterized by chemosensory functions, potential roles in immune regulation, and possible involvement in salivary secretion via acetylcholine release.",
          "xrefs" : [ "PMID:35993302", "PMID:38098741", "PMID:8874101" ]
        },
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          "val" : "2025-02-12T10:38:11Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052040",
      "lbl" : "tuft cell of stomach",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of the stomach. This cell is characterized by gastric chemosensation and immune regulation through IL-25 secretion, which activates ILC2s to produce IL-13, driving epithelial remodelling and tuft cell expansion. Unlike intestinal tuft cells, which are primarily involved in helminth defense and type 2 immunity, the tuft cell of the stomach is primarily involved in inflammation, metaplasia, and hyperplasia.",
          "xrefs" : [ "PMID:22527717", "PMID:38117182", "doi:/10.1101/2022.02.16.480779" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "gastric tuft cell",
          "xrefs" : [ "PMID:38117182" ]
        } ],
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          "val" : "2025-02-12T11:24:56Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052041",
      "lbl" : "tuft cell of auditory tube",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of the pharyngotympanic (auditory) tube. This chemosensory cell is often positioned near cholinoreceptive sensory nerve fibers, suggesting a role in neuroimmune communication. It detects chemical signals and releases neuropeptides, such as acetylcholine (ACh) and CGRP, which contribute to inflammatory responses that help protect deeper tissues from harmful substances.",
          "xrefs" : [ "PMID:30379593", "PMID:32733896" ]
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        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2025-02-12T12:00:10Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052042",
      "lbl" : "tuft cell of urethra",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tuft cell that is part of the epithelium of the urethra. This cell monitors urethral contents by detecting chemical stimuli, such as bitter compounds and sugars. Upon activation, it stimulates sensory nerve fibres and triggers detrusor muscle contraction, likely aiding in pathogen clearance by promoting bladder emptying.",
          "xrefs" : [ "PMID:30379593", "PMID:36993541", "PMID:38548667" ]
        },
        "comments" : [ "Urethral tuft cells are heterogeneous, with both cholinergic and non-cholinergic populations present." ],
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          "pred" : "hasExactSynonym",
          "val" : "urethral brush cell",
          "xrefs" : [ "PMID:38548667" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "urethral cholinergic chemosensory cell",
          "xrefs" : [ "PMID:38548667" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "urethral tuft cell",
          "xrefs" : [ "PMID:38548667" ]
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          "val" : "2025-02-12T14:39:03Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052045",
      "lbl" : "steroidogenic stromal cell of ovary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A stromal cell that is part of the ovarian stroma, characterized by its ability to synthesize steroid hormones.",
          "xrefs" : [ "PMID:36205477", "doi:/10.1101/2024.12.15.628550" ]
        },
        "synonyms" : [ {
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          "val" : "steroidogenic interstitial stromal cell",
          "xrefs" : [ "PMID:36205477" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "steroidogenic stromal cell",
          "xrefs" : [ "PMID:36205477" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Enpp2− interstitial cell",
          "xrefs" : [ "PMID:36205477" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2025-03-05T13:37:44Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052049",
      "lbl" : "striated cell of salivary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An columnar/cuboidal epithelial cell that is part of the striated duct of salivary gland, characterized by basal striations formed by infoldings of the plasma membrane. This cell play a crucial role in modifying the electrolyte composition and concentration of saliva through active ion transport, particularly the absorption of sodium and secretion of potassium.",
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        },
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        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "SD cells",
          "xrefs" : [ "PMID:11590591" ]
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "striated duct cells",
          "xrefs" : [ "PMID:11590591" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://orcid.org/0000-0003-4389-9821"
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          "val" : "https://orcid.org/0009-0000-8480-9277"
        }, {
          "pred" : "http://purl.org/dc/terms/date",
          "val" : "2024-09-11T10:00:25Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052050",
      "lbl" : "luminal epithelial cell of endometrium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that is part of an endometrium luminal epithelium.",
          "xrefs" : [ "PMID:36273006" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "endometrial luminal epithelial cell",
          "xrefs" : [ "PMID:31317179" ]
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          "val" : "2025-03-13T13:46:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052058",
      "lbl" : "Merkel cell of epidermis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A Merkel cell found mainly in the basal layer of the epidermis and the outer root sheath of hair follicles, particularly concentrated in areas with high tactile acuity, such as touch domes, hair follicles, and fingertips.",
          "xrefs" : [ "PMID:19834574", "PMID:2274847", "PMID:30415995", "Wikipedia:Merkel_cell" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "epdiermal Merkel cell",
          "xrefs" : [ "PMID:6207057" ]
        } ],
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          "val" : "2025-06-11T10:01:40Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052060",
      "lbl" : "spinous cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A differentiating keratinocyte found in the epidermis and oral epithelium, located in the stratum spinosum, characterized by a spiny appearance due to abundant intercellular desmosomal junctions.",
          "xrefs" : [ "PMID:34283481", "wikipedia:Spinous_cell" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "prickle cell",
          "xrefs" : [ "wikipedia:Spinous_cell" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2025-07-02T12:21:06Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052061",
      "lbl" : "epidermal keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A keratinocyte of the skin epidermis that synthesizes keratin and undergoes successive stages of differentiation as it migrates from the basal layer to the cornified (stratum corneum) layer. These differentiation stages include the basal, spinous (prickle), and granular cell layers. This cell is central to epidermal homeostasis, mediating wound healing, immune modulation, including the secretion of cytokines and chemokines that recruit neutrophils (Simmons and Gallo, 2024), and intercellular communication with adjacent melanocytes (Marrapodi and Bellei, 2024).",
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        },
        "comments" : [ "Keratinocytes are reportedly CDw210a(IL-10RA)-negative , CDw210b(IL-10RB)-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive." ],
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          "pred" : "hasExactSynonym",
          "val" : "keratincyte of epidermis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "skin keratinocyte",
          "xrefs" : [ "PMID:39185948" ]
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          "val" : "2025-07-02T12:32:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052064",
      "lbl" : "nail matrix keratinocyte",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A keratinocyte that is part of the nail matrix epithelium, distinguished by its high proliferative capacity and its role in nail plate formation via onychokeratinization, a differentiation process that uniquely bypasses the formation of a granular layer, resulting in the production of hard, compact keratin. Unlike skin epidermal keratinocytes, this cell expresses a distinctive mix of hard (hair-type) and select epidermal keratins (Kitahara and Ogawa, 1993). In humans, LGR6 and WNT6 are enriched in the basal compartment, with LGR6 marking nail stem cells in both mice and humans, and exhibiting strong expression in the human proximal nail matrix (Kim et al., 2021).",
          "xrefs" : [ "PMID:28098391", "PMID:30969555", "PMID:34099859", "PMID:39044464", "PMID:7679137" ]
        },
        "synonyms" : [ {
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          "val" : "nail matrix epithelial keratinocyte",
          "xrefs" : [ "PMID:39044464" ]
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          "val" : "2025-07-22T15:30:00Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052065",
      "lbl" : "serous acinar cell of salivary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An acinar cell of the salivary gland, characterized by a pyramidal or triangular shape with a spherical nucleus and abundant eosinophilic zymogen granules. This cell secretes watery, enzyme‐rich fluid containing α-amylase, proline-rich proteins, and secretory immunoglobulins for starch digestion and antimicrobial defence. In humans and mice, serous acinar cell predominates in the parotid gland and to a lesser extent in the submandibular gland, where it exists alongside mucous acinar cells (Maruyama et al., 2019).",
          "xrefs" : [ "PMID:29383862", "PMID:32829674", "PMID:35343828" ]
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          "val" : "2025-08-05T15:24:46Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4052066",
      "lbl" : "mucous acinar cell of salivary gland",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An acinar cell of the salivary gland, responsible for producing a viscous, mucin‐rich solution, thereby facilitating lubrication and protection of the oral mucosa. This cell is characterized by an elongated shape, clear cytoplasm filled with mucin granules, and a basally compressed nucleus (Barrows et al., 2020). In humans and mice, the mucous acinar cell predominates in the sublingual gland and minor salivary glands, while also being present in mixed glands such as the submandibular gland, where it coexists with serous acinar cells (Maruyama et al., 2019).",
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          "val" : "2025-08-05T15:33:46Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4072102",
      "lbl" : "Purkinje layer interneuron",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of GABAergic interneuron residing in the Purkinje cell layer of the cerebellar cortex.",
          "xrefs" : [ "PMID:35803588" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2025-04-29T13:06:36Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_4072103",
      "lbl" : "hair follicle dermal stem cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A bipotent mesenchymal stem cell that resides in the dermal sheath, specifically within the dermal sheath cup at the base of the hair follicle, characterized by its capacity for self-renewal and differentiation into both dermal sheath and dermal papilla cells throughout hair cycling. In humans, this cell is marked by enriched expression of gremlin-2 (GREM2) and dipeptidase-1 (DPEP1), and acts as a progenitor reservoir sustaining and regenerating the follicle's mesenchymal compartments.",
          "xrefs" : [ "PMID:25465495", "PMID:29691589", "PMID:35036581", "PMID:35069694" ]
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        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "dermal sheath cup cell",
          "xrefs" : [ "PMID:38016881" ]
        } ],
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          "val" : "2025-11-05T11:49:53Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/CL_7770004",
      "lbl" : "suprabasal cell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An epithelial cell that resides in the layer(s) immediately above the basal layer in stratified or pseudostratified epithelia. This cell mainly originates from basal cells and is found across various tissues, including skin, esophagus, oral mucosa, airway, and cornea.",
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          "val" : "2025-09-05T07:59:28Z"
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      "id" : "http://purl.obolibrary.org/obo/COB_0000013",
      "lbl" : "molecule",
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        "definition" : {
          "val" : "A material entity that consists of two or more atoms that are all connected via covalent bonds such that any atom can be transitively connected with any other atom."
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      "type" : "CLASS"
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000011",
      "lbl" : "vacuole inheritance",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000012",
      "lbl" : "single strand break repair",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair.",
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      "lbl" : "regulation of DNA recombination",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.",
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      "lbl" : "acyl binding",
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        "definition" : {
          "val" : "Binding to an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid.",
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        "synonyms" : [ {
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          "val" : "acyl-CoA or acyl binding"
        } ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0000041",
      "lbl" : "transition metal ion transport",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0000045",
      "lbl" : "autophagosome assembly",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm.",
          "xrefs" : [ "GOC:autophagy", "PMID:9412464" ]
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          "val" : "autophagic vacuole assembly",
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          "pred" : "hasExactSynonym",
          "val" : "autophagosome formation"
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          "val" : "PAS formation"
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          "val" : "autophagic vacuole formation",
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      "lbl" : "peptidyltransferase activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2). This reaction is catalyzed by a ribozyme.",
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        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-2500257"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016359"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000075",
      "lbl" : "cell cycle checkpoint signaling",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "comments" : [ "This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell cycle checkpoint"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "signal transduction involved in G2/M transition checkpoint"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "signal transduction involved in cell cycle checkpoint"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G1/S checkpoint"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G1/S transition checkpoint"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G2/M checkpoint"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G2/M transition checkpoint"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-69620"
        }, {
          "val" : "Wikipedia:Cell_cycle_checkpoint"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/20935"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0031576"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0071779"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0072395"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0072404"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0072407"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000086",
      "lbl" : "G2/M transition of mitotic cell cycle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitotic G2/M transition"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-69275"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000139",
      "lbl" : "Golgi membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The lipid bilayer surrounding any of the compartments of the Golgi apparatus.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Golgi apparatus membrane"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000166",
      "lbl" : "nucleotide binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.",
          "xrefs" : [ "GOC:mah", "ISBN:0198547684" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000212",
      "lbl" : "meiotic spindle organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle.",
          "xrefs" : [ "GOC:go_curators", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "meiotic spindle organisation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "spindle organization during meiosis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "meiotic spindle organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "meiotic spindle stabilization"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0043147"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000226",
      "lbl" : "microtubule cytoskeleton organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pombe" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "microtubule cytoskeleton organisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "microtubule cytoskeleton organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/23114"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/23195"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000228",
      "lbl" : "nuclear chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact.",
          "xrefs" : [ "GOC:dph", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "nuclear interphase chromosome"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000262",
      "lbl" : "mitochondrial chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A chromosome found in the mitochondrion of a eukaryotic cell.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "mitochondrial DNA"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mtDNA"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrial genome"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1186327184"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000266",
      "lbl" : "mitochondrial fission",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.",
          "xrefs" : [ "PMID:11038192" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrial division"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrial proliferation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000271",
      "lbl" : "polysaccharide biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glycan biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glycan biosynthetic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000272",
      "lbl" : "polysaccharide catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.",
          "xrefs" : [ "PMID:33139480" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "polysaccharide degradation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organismal polysaccharide catabolic process"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044244"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000278",
      "lbl" : "mitotic cell cycle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.",
          "xrefs" : [ "GOC:mah", "ISBN:0815316194" ]
        },
        "comments" : [ "Note that this term should not be confused with 'GO:0140014 ; mitotic nuclear division'. 'GO:0000278 ; mitotic cell cycle represents the entire mitotic cell cycle, while 'GO:0140014 ; mitotic nuclear division' specifically represents the actual nuclear division step of the mitotic cell cycle." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "mitosis"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-69278"
        }, {
          "val" : "Wikipedia:Mitosis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0007067"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000280",
      "lbl" : "nuclear division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "karyokinesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000281",
      "lbl" : "mitotic cytokinesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pombe" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cytokinesis after mitosis"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-68884"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000295",
      "lbl" : "adenine nucleotide transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other.",
          "xrefs" : [ "PMID:11566870" ]
        },
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-389652"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000313",
      "lbl" : "organellar ribosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A ribosome contained within a subcellular membrane-bounded organelle.",
          "xrefs" : [ "GOC:mah", "GOC:mcc" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000323",
      "lbl" : "lytic vacuole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases.",
          "xrefs" : [ "GOC:krc" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000422",
      "lbl" : "autophagy of mitochondrion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The autophagic process in which mitochondria are delivered to a type of vacuole and degraded in response to changing cellular conditions.",
          "xrefs" : [ "GOC:autophagy", "PMID:15798367", "PMID:19289147", "PMID:23065344" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "mitochondrion degradation"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "mitochondrion disassembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitophagy"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/25541"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000578",
      "lbl" : "embryonic axis specification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo.",
          "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:sdb_2009", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "embryonic axis determination"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000731",
      "lbl" : "DNA synthesis involved in DNA repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template.",
          "xrefs" : [ "PMID:10357855" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "DNA repair synthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitotic DNA repair synthesis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "DNA synthesis during DNA repair",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000740",
      "lbl" : "nuclear membrane fusion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The joining of 2 or more lipid bilayer membranes that surround the nucleus.",
          "xrefs" : [ "GOC:elh" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000741",
      "lbl" : "karyogamy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei.",
          "xrefs" : [ "GOC:elh" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nuclear fusion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "nuclear fusion during karyogamy"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Karyogamy"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0007335"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000768",
      "lbl" : "syncytium formation by plasma membrane fusion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.",
          "xrefs" : [ "GOC:mtg_muscle", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cell fusion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000781",
      "lbl" : "chromosome, telomeric region",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The end of a linear chromosome, required for the integrity and maintenance of the end. A chromosome telomere usually includes a region of telomerase-encoded repeats the length of which rarely exceeds 20 bp each and that permits the formation of a telomeric loop (T-loop). The telomeric repeat region is usually preceded by a sub-telomeric region that is gene-poor but rich in repetitive elements. Some telomeres only consist of the latter part (for eg. D. melanogaster telomeres).",
          "xrefs" : [ "GOC:elh" ]
        },
        "comments" : [ "Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex." ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "nuclear chromosome, telomere"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "nuclear chromosome, telomeric region"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "telomere"
        } ],
        "xrefs" : [ {
          "val" : "SO:0000624"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0000784"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000785",
      "lbl" : "chromatin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.",
          "xrefs" : [ "GOC:elh", "PMID:20404130" ]
        },
        "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "cytoplasmic chromatin"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "nuclear chromatin"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chromosome scaffold"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1615953555"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28301"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0000789"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0000790"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005717"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000791",
      "lbl" : "euchromatin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.",
          "xrefs" : [ "PMID:32017156" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transcriptionally active chromatin"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nuclear euchromatin"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao445485807"
        }, {
          "val" : "Wikipedia:Euchromatin"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22355"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005719"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0035327"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000792",
      "lbl" : "heterochromatin",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A compact and highly condensed form of chromatin that is refractory to transcription.",
          "xrefs" : [ "PMID:32017156" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transcriptionally inactive chromatin"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transcriptionally silent chromatin"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "nuclear heterochromatin"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao581845896"
        }, {
          "val" : "Wikipedia:Heterochromatin"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22355"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005720"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0035328"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000793",
      "lbl" : "condensed chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure.",
          "xrefs" : [ "GOC:elh" ]
        },
        "comments" : [ "Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cytoplasmic mitotic chromosome"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "metaphase chromosome"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitotic chromosome"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000794",
      "lbl" : "condensed nuclear chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.",
          "xrefs" : [ "GOC:elh" ]
        },
        "comments" : [ "Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "meiotic chromosome"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nuclear mitotic chromosome"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000795",
      "lbl" : "synaptonemal complex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element.",
          "xrefs" : [ "DOI:10.5772/29752", "GOC:elh" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Synaptonemal_complex"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005716"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000819",
      "lbl" : "sister chromatid segregation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets.",
          "xrefs" : [ "GOC:ai", "GOC:elh" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000902",
      "lbl" : "cell morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental process in which the size or shape of a cell is generated and organized.",
          "xrefs" : [ "GOC:clt", "GOC:dph", "GOC:go_curators", "GOC:tb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cellular morphogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0007148"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0045790"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0045791"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000910",
      "lbl" : "cytokinesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "comments" : [ "Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell cycle cytokinesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cytokinesis involved in cell cycle",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Cytokinesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0007104"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016288"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0033205"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000917",
      "lbl" : "division septum assembly",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "septation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "division septum formation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formation of division septum"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "division septum assembly involved in cell cycle cytokinesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "division septum formation involved in cell cycle cytokinesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "division septum formation involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "formation of division septum involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitotic division septum assembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "septin assembly and septum biosynthesis involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "septin assembly and septum formation involved in mitotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "septin assembly and septum biosynthesis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "septin assembly and septum formation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0071937"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:1902411"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0000959",
      "lbl" : "mitochondrial RNA metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion.",
          "xrefs" : [ "GOC:krc", "GOC:mah" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001101",
      "lbl" : "response to acid chemical",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.",
          "xrefs" : [ "GOC:go_curators", "GOC:rn" ]
        },
        "comments" : [ "This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "response to acid"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "response to acid anion"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "response to oxoanion"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001501",
      "lbl" : "skeletal system development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton).",
          "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "skeletal development"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001503",
      "lbl" : "ossification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.",
          "xrefs" : [ "GOC:mtg_mpo", "PMID:17572649" ]
        },
        "comments" : [ "Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "bone biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "bone formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "osteogenesis"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Ossification"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001504",
      "lbl" : "neurotransmitter uptake",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters.",
          "xrefs" : [ "ISBN:0123668387" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "neurotransmitter recycling"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neurotransmitter import",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "neurotransmitter import into glial cell"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "neurotransmitter import into neuron"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-112313"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001507",
      "lbl" : "acetylcholine catabolic process in synaptic cleft",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine breakdown in synaptic cleft"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine degradation in synaptic cleft"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001508",
      "lbl" : "action potential",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities.",
          "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb", "ISBN:978-0-07-139011-8" ]
        },
        "comments" : [ "Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so." ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001520",
      "lbl" : "outer dense fiber",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins.",
          "xrefs" : [ "GOC:cilia", "GOC:krc", "ISBN:0824072820", "PMID:10381817", "PMID:21586547", "PMID:25361759" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "outer dense fibre"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001523",
      "lbl" : "retinoid metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "retinoid metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-2187335"
        }, {
          "val" : "Reactome:R-HSA-2453902"
        }, {
          "val" : "Reactome:R-HSA-975634"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001525",
      "lbl" : "angiogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels.",
          "xrefs" : [ "ISBN:0878932453" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Angiogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001533",
      "lbl" : "cornified envelope",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes).",
          "xrefs" : [ "GOC:add", "PMID:11112355", "PMID:11590230", "PMID:15803139" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001534",
      "lbl" : "radial spoke",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Protein complex that links the outer microtubule doublet of a 9+2 type ciliary or flagellar axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules.",
          "xrefs" : [ "GOC:krc", "ISBN:0124325653", "PMID:22118931", "PMID:25694453", "PMID:34871179", "PMID:9450971" ]
        },
        "comments" : [ "Radial spokes are involved in some types of beating motions of the cilium. The radial spoke is usually a T-shaped structure comprised of a short base that attaches to the A-microtubule of an axonemal outer microtubule doublet (MTD) of a cilium, an elongated stalk, a neck complex, and an orthogonal head structure that extends perpendicularly towards the inner sheath and the central pair (CP) microtubules. Groups of radial spokes (RSs) repeat along the MTD with regular spacing. In most organisms, each group of radial spokes is comprised of a triplet of spokes: RS1, RS2, and RS3. In some organisms (e.g. Chlamydomonas and Sarcophaga bullata), each group contains a doublet of radial spokes: RS1 and RS2, while RS3 is represented only as a stump (referred to as RS3S) attached to the A-microtubule but lacking the rest of the stalk structure and entirely lacking the head structure." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Radial_spoke"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/25321"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001539",
      "lbl" : "cilium or flagellum-dependent cell motility",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella.",
          "xrefs" : [ "GOC:cilia", "GOC:hjd", "GOC:krc" ]
        },
        "comments" : [ "Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ciliary/flagellar motility"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "ciliary or bacterial-type flagellar motility"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001541",
      "lbl" : "ovarian follicle development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure.",
          "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "follicular phase"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001542",
      "lbl" : "ovulation from ovarian follicle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus.",
          "xrefs" : [ "GOC:mtg_sensu", "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001545",
      "lbl" : "primary ovarian follicle growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle).",
          "xrefs" : [ "GOC:mtg_mpo", "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001546",
      "lbl" : "preantral ovarian follicle growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation.",
          "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001547",
      "lbl" : "antral ovarian follicle growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity.",
          "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001550",
      "lbl" : "ovarian cumulus expansion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells.",
          "xrefs" : [ "PMID:30010832" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "ovarian cumulus growth"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001553",
      "lbl" : "luteinization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation.",
          "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "luteal phase"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Luteal_phase"
        }, {
          "val" : "Wikipedia:Luteinization"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001555",
      "lbl" : "oocyte growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.",
          "xrefs" : [ "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001556",
      "lbl" : "oocyte maturation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.",
          "xrefs" : [ "GOC:devbiol", "https://www.ncbi.nlm.nih.gov/books/NBK279054/" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Oocyte_maturation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001558",
      "lbl" : "regulation of cell growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, extent or direction of cell growth.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001560",
      "lbl" : "regulation of cell growth by extracellular stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time.",
          "xrefs" : [ "GOC:dph" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "interpretation of external signals that regulate cell growth"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cell growth by detection of exogenous stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cell growth by sensing of exogenous stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by exogenous signal"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by exogenous stimuli"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by exogenous stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by external signal"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by external stimuli"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of growth by external stimulus"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001568",
      "lbl" : "blood vessel development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood.",
          "xrefs" : [ "GOC:hjd", "UBERON:0001981" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001569",
      "lbl" : "branching involved in blood vessel morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system.",
          "xrefs" : [ "GOC:dph" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "patterning of blood vessels",
          "xrefs" : [ "GOC:dph" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001570",
      "lbl" : "vasculogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes.",
          "xrefs" : [ "PMID:8999798" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "vascular morphogenesis"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Vasculogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001578",
      "lbl" : "microtubule bundle formation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that results in a parallel arrangement of microtubules.",
          "xrefs" : [ "GOC:dph" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "microtubule bundling"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001580",
      "lbl" : "detection of chemical stimulus involved in sensory perception of bitter taste",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "bitter taste detection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perception of bitter taste, detection of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perception of bitter taste, sensory transduction of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of bitter taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of chemical stimulus during perception of bitter taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of bitter taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of chemical stimulus during perception of bitter taste"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001581",
      "lbl" : "detection of chemical stimulus involved in sensory perception of sour taste",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of events required for a sour taste stimulus to be received and converted to a molecular signal.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "perception of sour taste, detection of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perception of sour taste, sensory transduction of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of chemical stimulus during perception of sour taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of sour taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of chemical stimulus during perception of sour taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of sour taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sour taste detection"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001582",
      "lbl" : "detection of chemical stimulus involved in sensory perception of sweet taste",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "perception of sweet taste, detection of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perception of sweet taste, sensory transduction of chemical stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of chemical stimulus during perception of sweet taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory detection of sweet taste"
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          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of chemical stimulus during perception of sweet taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sensory transduction of sweet taste"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sweet taste detection"
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001609",
      "lbl" : "G protein-coupled adenosine receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
          "xrefs" : [ "GOC:bf", "GOC:mah", "PMID:9755289" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "adenosine nucleotide receptor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G protein coupled adenosine receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled adenosine receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "P1 receptor",
          "xrefs" : [ "PMID:9755289" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adenosine receptor activity, G protein coupled"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adenosine receptor activity, G-protein coupled",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A1 adenosine receptor activity, G protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A1 adenosine receptor activity, G-protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A2A adenosine receptor activity, G protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A2A adenosine receptor activity, G-protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A2B adenosine receptor activity, G protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A2B adenosine receptor activity, G-protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A3 adenosine receptor activity, G protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "A3 adenosine receptor activity, G-protein coupled"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G protein coupled A1 adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G protein coupled A2A adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G protein coupled A2B adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G protein coupled A3 adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein-coupled A1 adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein-coupled A2A adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein-coupled A2B adenosine receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein-coupled A3 adenosine receptor activity"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0001613"
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      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0001614",
      "lbl" : "purinergic nucleotide receptor activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.",
          "xrefs" : [ "GOC:mah", "GOC:signaling" ]
        },
        "synonyms" : [ {
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          "val" : "purinoceptor",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "purinoreceptor",
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          "pred" : "hasRelatedSynonym",
          "val" : "P2 receptor",
          "xrefs" : [ "PMID:9755289" ]
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          "pred" : "hasRelatedSynonym",
          "val" : "purinergic receptor activity"
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          "val" : "2010-10-22T10:57:12Z"
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          "val" : "GO:0035586"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001621",
      "lbl" : "G protein-coupled ADP receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with ADP and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
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        },
        "synonyms" : [ {
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          "val" : "ADP receptor activity"
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          "pred" : "hasBroadSynonym",
          "val" : "ADP-activated nucleotide receptor activity"
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          "pred" : "hasNarrowSynonym",
          "val" : "K101 receptor"
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          "pred" : "hasNarrowSynonym",
          "val" : "platelet ADP receptor activity",
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        } ],
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          "val" : "GO:0045032"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001649",
      "lbl" : "osteoblast differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.",
          "xrefs" : [ "CL:0000062", "GOC:jid", "GO_REF:0000034" ]
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          "val" : "osteoblast cell differentiation"
        } ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0001653",
      "lbl" : "peptide receptor activity",
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        "definition" : {
          "val" : "Combining with an extracellular or intracellular peptide to initiate a change in cell activity.",
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          "val" : "endogenous peptide receptor activity"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001654",
      "lbl" : "eye development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight.",
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        } ],
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001655",
      "lbl" : "urogenital system development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure.",
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        },
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0001656",
      "lbl" : "metanephros development",
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          "val" : "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001657",
      "lbl" : "ureteric bud development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001658",
      "lbl" : "branching involved in ureteric bud morphogenesis",
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        "definition" : {
          "val" : "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001659",
      "lbl" : "temperature homeostasis",
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        "definition" : {
          "val" : "A homeostatic process in which an organism modulates its internal body temperature.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001664",
      "lbl" : "G protein-coupled receptor binding",
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        "definition" : {
          "val" : "Binding to a G protein-coupled receptor.",
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          "pred" : "hasExactSynonym",
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          "val" : "G protein coupled receptor ligand"
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      "id" : "http://purl.obolibrary.org/obo/GO_0001666",
      "lbl" : "response to hypoxia",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.",
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          "val" : "response to intermittent hypoxia"
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          "val" : "response to sustained hypoxia"
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      "id" : "http://purl.obolibrary.org/obo/GO_0001667",
      "lbl" : "ameboidal-type cell migration",
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        "definition" : {
          "val" : "Cell migration that is accomplished by extension and retraction of a pseudopodium.",
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        },
        "comments" : [ "Note that this term refers to a mode of migration rather than to any particular cell type." ],
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          "val" : "ameboid cell migration"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amoeboid cell migration"
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001669",
      "lbl" : "acrosomal vesicle",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome.",
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001673",
      "lbl" : "male germ cell nucleus",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The nucleus of a male germ cell, a reproductive cell in males.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001674",
      "lbl" : "female germ cell nucleus",
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        "definition" : {
          "val" : "The nucleus of the female germ cell, a reproductive cell in females.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001675",
      "lbl" : "acrosome assembly",
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        "definition" : {
          "val" : "The formation of the acrosome from the spermatid Golgi.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001677",
      "lbl" : "formation of translation initiation ternary complex",
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          "val" : "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator).",
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      "lbl" : "intracellular glucose homeostasis",
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          "val" : "cell glucose homeostasis",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001692",
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          "val" : "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.",
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          "val" : "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.",
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          "pred" : "hasExactSynonym",
          "val" : "histamine formation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0001696",
      "lbl" : "gastric acid secretion",
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          "val" : "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion.",
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          "val" : "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001745",
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          "val" : "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.",
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      "meta" : {
        "definition" : {
          "val" : "The outer segment of a vertebrate photoreceptor that contains a stack of membrane discs embedded with photoreceptor proteins.",
          "xrefs" : [ "GOC:cilia", "GOC:krc", "GOC:pde", "ISBN:0824072820", "PMID:19501669", "PMID:26574505", "PMID:6771304" ]
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        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001751",
      "lbl" : "compound eye photoreceptor cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell.",
          "xrefs" : [ "GOC:go_curators" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001754",
      "lbl" : "eye photoreceptor cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms.",
          "xrefs" : [ "GOC:go_curators" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001755",
      "lbl" : "neural crest cell migration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "ISBN:0878932437" ]
        },
        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001756",
      "lbl" : "somitogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.",
          "xrefs" : [ "ISBN:0721662544" ]
        },
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9824272"
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          "val" : "Wikipedia:Somitogenesis"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001763",
      "lbl" : "morphogenesis of a branching structure",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes.",
          "xrefs" : [ "ISBN:0721662544" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "branching morphogenesis",
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001764",
      "lbl" : "neuron migration",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.",
          "xrefs" : [ "CL:0000540", "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuron chemotaxis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neuronal migration"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "neuron guidance"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Neural_development#Neuron_migration"
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          "val" : "Wikipedia:Neuron_migration"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001767",
      "lbl" : "establishment of lymphocyte polarity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lymphocyte polarization"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001768",
      "lbl" : "establishment of T cell polarity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:11244041", "PMID:12615889" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T cell polarization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T lymphocyte polarization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-cell polarization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of T lymphocyte polarity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of T-cell polarity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of T-lymphocyte polarity"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001769",
      "lbl" : "establishment of B cell polarity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:12615889", "PMID:9692889" ]
        },
        "comments" : [ "Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B cell polarization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte polarization"
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          "pred" : "hasExactSynonym",
          "val" : "B-cell polarization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of B lymphocyte polarity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of B-cell polarity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of B-lymphocyte polarity"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001770",
      "lbl" : "establishment of natural killer cell polarity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:12615886", "PMID:9759849" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "NK cell polarization"
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          "pred" : "hasExactSynonym",
          "val" : "establishment of NK cell polarity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "natural killer cell polarization"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001773",
      "lbl" : "myeloid dendritic cell activation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.",
          "xrefs" : [ "GOC:mgi_curators", "ISBN:0781735149" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001774",
      "lbl" : "microglial cell activation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:10626665", "PMID:10695728", "PMID:12580336", "PMID:9893949" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001775",
      "lbl" : "cell activation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A multicellular organismal process by which exposure to an activating factor such as a cellular or soluble ligand results in a change in the morphology or behavior of a cell.",
          "xrefs" : [ "GOC:mgi_curators" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001776",
      "lbl" : "leukocyte homeostasis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus." ],
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          "pred" : "hasExactSynonym",
          "val" : "immune cell homeostasis"
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          "pred" : "hasExactSynonym",
          "val" : "leucocyte homeostasis"
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      "id" : "http://purl.obolibrary.org/obo/GO_0001777",
      "lbl" : "T cell homeostatic proliferation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus.",
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        "synonyms" : [ {
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          "val" : "T lymphocyte homeostatic proliferation"
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          "pred" : "hasExactSynonym",
          "val" : "T-cell homeostatic proliferation"
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          "pred" : "hasExactSynonym",
          "val" : "T-lymphocyte homeostatic proliferation"
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001779",
      "lbl" : "natural killer cell differentiation",
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        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell.",
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        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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          "val" : "NK cell differentiation"
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          "pred" : "hasRelatedSynonym",
          "val" : "natural killer cell development",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001780",
      "lbl" : "neutrophil homeostasis",
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        "definition" : {
          "val" : "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus.",
          "xrefs" : [ "GOC:add", "GOC:pr", "PMID:12752675", "PMID:12960266" ]
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        "comments" : [ "Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus." ]
      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0001781",
      "lbl" : "neutrophil apoptotic process",
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        "definition" : {
          "val" : "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.",
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          "val" : "apoptosis of neutrophils"
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001782",
      "lbl" : "B cell homeostasis",
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        "definition" : {
          "val" : "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.",
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        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001783",
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        "definition" : {
          "val" : "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.",
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          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte apoptosis"
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte apoptosis"
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "apoptosis of B-lymphocytes"
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        }, {
          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of type IV hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of type IV hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of type IV hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of type IV hypersensitivity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001809",
      "lbl" : "positive regulation of type IV hypersensitivity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of type IV hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of type IV hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of type IV hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of type IV hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of type IV hypersensitivity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001810",
      "lbl" : "regulation of type I hypersensitivity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response.",
          "xrefs" : [ "ISBN:0781735149" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001811",
      "lbl" : "negative regulation of type I hypersensitivity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of type I hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of type I hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of type I hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of type I hypersensitivity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001812",
      "lbl" : "positive regulation of type I hypersensitivity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of type I hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of type I hypersensitivity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of type I hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of type I hypersensitivity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of type I hypersensitivity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001816",
      "lbl" : "cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "cytokine biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "cytokine metabolic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "cytokine secretion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "interferon production",
          "xrefs" : [ "GOC:add", "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "interferon secretion",
          "xrefs" : [ "GOC:add", "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "interleukin production",
          "xrefs" : [ "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "interleukin secretion",
          "xrefs" : [ "GOC:add", "GOC:mah", "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/19116"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042032"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042089"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042107"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0050663"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001817",
      "lbl" : "regulation of cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of production of a cytokine.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cytokine anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cytokine biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cytokine formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cytokine synthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of cytokine secretion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042035"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0050707"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001818",
      "lbl" : "negative regulation of cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the rate of production of a cytokine.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of cytokine anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of cytokine biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of cytokine formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of cytokine synthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of cytokine biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of cytokine secretion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042036"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0050710"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001819",
      "lbl" : "positive regulation of cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of production of a cytokine.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of cytokine biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of cytokine secretion"
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          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of cytokine production"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0042108"
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          "val" : "GO:0050715"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001820",
      "lbl" : "serotonin secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesized in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells.",
          "xrefs" : [ "GOC:ef", "ISBN:0198506732", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "5-HT secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "5-hydroxytryptamine secretion"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "serotonin release",
          "xrefs" : [ "GOC:tb" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001821",
      "lbl" : "histamine secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems.",
          "xrefs" : [ "GOC:mah", "ISBN:0198506732", "ISBN:0781735149" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001822",
      "lbl" : "kidney development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_kidney_jan10", "ISBN:0124020607", "ISBN:0721662544" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "nephrogenesis",
          "xrefs" : [ "GOC:rph" ]
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        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9830369"
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          "val" : "Wikipedia:Kidney_development"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001823",
      "lbl" : "mesonephros development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0721662544", "PMID:10535314" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Wolffian body development",
          "xrefs" : [ "GOC:dph" ]
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001824",
      "lbl" : "blastocyst development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm. The blastula follows the morula and precedes the gastrula in the developmental sequence.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "blastula development"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001825",
      "lbl" : "blastocyst formation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The initial formation of a blastocyst from a solid ball of cells known as a morula.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001826",
      "lbl" : "inner cell mass cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001829",
      "lbl" : "trophectodermal cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "trophectoderm cell differentiation"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001831",
      "lbl" : "trophectodermal cellular morphogenesis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The morphogenesis of trophectoderm cells.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "trophectoderm cellular morphogenesis"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001832",
      "lbl" : "blastocyst growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'." ],
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          "val" : "blastula growth"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001833",
      "lbl" : "inner cell mass cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The proliferation of cells in the inner cell mass.",
          "xrefs" : [ "GOC:dph", "GOC:isa_complete", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'." ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0001834",
      "lbl" : "trophectodermal cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The proliferation of cells in the trophectoderm.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
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      "id" : "http://purl.obolibrary.org/obo/GO_0001835",
      "lbl" : "blastocyst hatching",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The hatching of the cellular blastocyst from the zona pellucida.",
          "xrefs" : [ "GOC:dph", "ISBN:0124020607", "ISBN:0198542771" ]
        },
        "comments" : [ "See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'." ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0001837",
      "lbl" : "epithelial to mesenchymal transition",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.",
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          "val" : "epithelial-mesenchymal transition"
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          "val" : "Reactome:R-HSA-9758919"
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      "id" : "http://purl.obolibrary.org/obo/GO_0001838",
      "lbl" : "embryonic epithelial tube formation",
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        "definition" : {
          "val" : "The morphogenesis of an embryonic epithelium into a tube-shaped structure.",
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      "lbl" : "neural plate morphogenesis",
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      "lbl" : "neural plate development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system.",
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      "lbl" : "neural tube formation",
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          "val" : "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.",
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      "lbl" : "neural fold formation",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001843",
      "lbl" : "neural tube closure",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001873",
      "lbl" : "polysaccharide immune receptor activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Combining with a polysaccharide and transmitting the signal to initiate an innate immune response. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001880",
      "lbl" : "Mullerian duct regression",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos.",
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      "lbl" : "nucleoside binding",
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        "definition" : {
          "val" : "Binding to a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001883",
      "lbl" : "purine nucleoside binding",
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        "definition" : {
          "val" : "Binding to a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001885",
      "lbl" : "endothelial cell development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The progression of an endothelial cell over time, from its formation to the mature structure.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001886",
      "lbl" : "endothelial cell morphogenesis",
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        "definition" : {
          "val" : "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001889",
      "lbl" : "liver development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes.",
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      "lbl" : "placenta development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.",
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        "synonyms" : [ {
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          "val" : "placental development"
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          "pred" : "hasExactSynonym",
          "val" : "placentation",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001892",
      "lbl" : "embryonic placenta development",
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        "definition" : {
          "val" : "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0001893",
      "lbl" : "maternal placenta development",
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        "definition" : {
          "val" : "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.",
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          "val" : "decidua development",
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      "lbl" : "tissue homeostasis",
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        "definition" : {
          "val" : "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function.",
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        "definition" : {
          "val" : "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.",
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      "lbl" : "leukocyte mediated cytotoxicity",
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        "comments" : [ "Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system." ],
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          "val" : "positive regulation of T cell mediated cell death"
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          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T cell mediated cell killing"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T lymphocyte mediated cytotoxicity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-cell mediated apoptosis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-cell mediated cell death"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-cell mediated cell killing"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-cell mediated cytotoxicity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-lymphocyte mediated cytotoxicity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of T cell mediated cytotoxicity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of T cell mediated cytotoxicity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of T cell mediated cytotoxicity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of T cell mediated cytotoxicity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of T cell mediated cytotoxicity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of T cell mediated cytolysis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of T-cell mediated cytolysis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001917",
      "lbl" : "photoreceptor inner segment",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs.",
          "xrefs" : [ "GOC:add", "PMID:12019563" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001922",
      "lbl" : "B-1 B cell homeostasis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B lymphocyte homeostasis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-cell homeostasis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-lymphocyte homeostasis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001923",
      "lbl" : "B-1 B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "B-1 B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001924",
      "lbl" : "regulation of B-1 B cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B-1 B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B-1 B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B-1 B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "regulation of B-1 B cell development",
          "xrefs" : [ "GOC:add" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001925",
      "lbl" : "negative regulation of B-1 B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B-1 B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B-1 B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B-1 B-lymphocyte differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of B-1 B cell differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of B-1 B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001926",
      "lbl" : "positive regulation of B-1 B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B-1 B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B-1 B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B-1 B-lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of B-1 B cell differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of B-1 B cell differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of B-1 B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001932",
      "lbl" : "regulation of protein phosphorylation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.",
          "xrefs" : [ "GOC:hjd" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of protein amino acid phosphorylation",
          "xrefs" : [ "GOC:bf" ]
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        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001933",
      "lbl" : "negative regulation of protein phosphorylation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.",
          "xrefs" : [ "GOC:hjd" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of protein amino acid phosphorylation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of protein amino acid phosphorylation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of protein amino acid phosphorylation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of protein amino acid phosphorylation",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of protein amino acid phosphorylation"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001934",
      "lbl" : "positive regulation of protein phosphorylation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
        "synonyms" : [ {
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "up-regulation of protein amino acid phosphorylation"
        }, {
          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of protein amino acid phosphorylation"
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          "pred" : "hasNarrowSynonym",
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001935",
      "lbl" : "endothelial cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001936",
      "lbl" : "regulation of endothelial cell proliferation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation.",
          "xrefs" : [ "GOC:add" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001937",
      "lbl" : "negative regulation of endothelial cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of endothelial cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of endothelial cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of endothelial cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of endothelial cell proliferation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001938",
      "lbl" : "positive regulation of endothelial cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the rate or extent of endothelial cell proliferation.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of endothelial cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of endothelial cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of endothelial cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of endothelial cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of endothelial cell proliferation"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001940",
      "lbl" : "male pronucleus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The pronucleus originating from the spermatozoa that was involved in fertilization.",
          "xrefs" : [ "GOC:hjd", "ISBN:0198506732" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001941",
      "lbl" : "postsynaptic membrane organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).",
          "xrefs" : [ "GOC:dph", "GOC:pr" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "post-synaptic membrane organization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "postsynaptic membrane organisation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001942",
      "lbl" : "hair follicle development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open.",
          "xrefs" : [ "GOC:dph", "UBERON:0002073" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001943"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001944",
      "lbl" : "vasculature development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism.",
          "xrefs" : [ "GOC:dph", "UBERON:0002409" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "vascular system development"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001945",
      "lbl" : "lymph vessel development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure.",
          "xrefs" : [ "GOC:dph", "UBERON:0001473" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001946",
      "lbl" : "lymphangiogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels.",
          "xrefs" : [ "GOC:dph", "PMID:11596157" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Lymphangiogenesis"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001947",
      "lbl" : "heart looping",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceding septation.",
          "xrefs" : [ "GOC:dph", "PMID:12094232" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cardiac looping"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001949",
      "lbl" : "sebaceous gland cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:15737203" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "sebocytes differentiation",
          "xrefs" : [ "GOC:mgi_curators" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001951",
      "lbl" : "intestinal D-glucose absorption",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Uptake of D-glucose into the blood by absorption from the small intestine.",
          "xrefs" : [ "GOC:mgi_curators", "PMID:5601832" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001955",
      "lbl" : "blood vessel maturation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state.",
          "xrefs" : [ "GOC:dph" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001956",
      "lbl" : "positive regulation of neurotransmitter secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter.",
          "xrefs" : [ "GOC:hjd" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of neurotransmitter secretion"
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          "pred" : "hasExactSynonym",
          "val" : "up-regulation of neurotransmitter secretion"
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          "pred" : "hasExactSynonym",
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        }, {
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          "val" : "activation of neurotransmitter secretion"
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          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of neurotransmitter secretion"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0001957",
      "lbl" : "intramembranous ossification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells.",
          "xrefs" : [ "ISBN:0878932437" ]
        },
        "comments" : [ "An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division." ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "dermal ossification",
          "xrefs" : [ "GO_REF:0000034" ]
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          "pred" : "hasRelatedSynonym",
          "val" : "intramembranous bone ossification",
          "xrefs" : [ "GOC:cjm" ]
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        "xrefs" : [ {
          "val" : "Wikipedia:Intramembranous_ossification"
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          "val" : "2012-06-13T07:34:38Z"
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          "val" : "GO:1900922"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002052",
      "lbl" : "positive regulation of neuroblast proliferation",
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        "definition" : {
          "val" : "Any process that activates or increases the rate of neuroblast proliferation.",
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          "val" : "activation of neuroblast proliferation"
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          "val" : "stimulation of neuroblast proliferation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002053",
      "lbl" : "positive regulation of mesenchymal cell proliferation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells.",
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          "val" : "upregulation of mesenchymal cell proliferation"
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          "val" : "activation of mesenchymal cell proliferation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002054",
      "lbl" : "nucleobase binding",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Binding to a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002055",
      "lbl" : "adenine binding",
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        "definition" : {
          "val" : "Binding to adenine, a purine base.",
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          "val" : "6-aminopurine binding"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002060",
      "lbl" : "purine nucleobase binding",
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        "definition" : {
          "val" : "Binding to a purine nucleobase, an organic nitrogenous base with a purine skeleton.",
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          "val" : "purine binding"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002062",
      "lbl" : "chondrocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.",
          "xrefs" : [ "GOC:dph" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0002063",
      "lbl" : "chondrocyte development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate.",
          "xrefs" : [ "GOC:dph" ]
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      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0002064",
      "lbl" : "epithelial cell development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002065",
      "lbl" : "columnar/cuboidal epithelial cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002066",
      "lbl" : "columnar/cuboidal epithelial cell development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002067",
      "lbl" : "glandular epithelial cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.",
          "xrefs" : [ "GOC:dph" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002068",
      "lbl" : "glandular epithelial cell development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.",
          "xrefs" : [ "GOC:dph" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0002069",
      "lbl" : "columnar/cuboidal epithelial cell maturation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube.",
          "xrefs" : [ "GOC:dph" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002070",
      "lbl" : "epithelial cell maturation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface.",
          "xrefs" : [ "GOC:dph" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0002071",
      "lbl" : "glandular epithelial cell maturation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland.",
          "xrefs" : [ "GOC:dph" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002072",
      "lbl" : "optic cup morphogenesis involved in camera-type eye development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus.",
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          "val" : "optic cup morphogenesis involved in camera-style eye development"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002074",
      "lbl" : "extraocular skeletal muscle development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_muscle", "GOC:mtg_sensu", "MA:0001271", "PMID:16638982" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002076",
      "lbl" : "osteoblast development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone.",
          "xrefs" : [ "GOC:dph" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002078",
      "lbl" : "membrane fusion involved in acrosome reaction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane.",
          "xrefs" : [ "GOC:dph", "PMID:3886029" ]
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        "synonyms" : [ {
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          "val" : "membrane fusion involved in the acrosomal reaction"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002080",
      "lbl" : "acrosomal membrane",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization.",
          "xrefs" : [ "GOC:dph" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0002082",
      "lbl" : "regulation of oxidative phosphorylation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.",
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          "pred" : "hasExactSynonym",
          "val" : "OXPHOS"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002085",
      "lbl" : "inhibition of neuroepithelial cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells.",
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        "synonyms" : [ {
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          "val" : "negative regulation of neural plate formation",
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          "pred" : "hasNarrowSynonym",
          "val" : "repression of premature neural plate formation",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002087",
      "lbl" : "regulation of respiratory gaseous exchange by nervous system process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates.",
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      "lbl" : "lens development in camera-type eye",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.",
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      "lbl" : "lens morphogenesis in camera-type eye",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002093",
      "lbl" : "auditory receptor cell morphogenesis",
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        "definition" : {
          "val" : "Any process that alters the size or shape of an auditory receptor cell.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002119",
      "lbl" : "nematode larval development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002158",
      "lbl" : "osteoclast proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes.",
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          "val" : "2010-02-03T01:50:37Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002159",
      "lbl" : "desmosome assembly",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002164",
      "lbl" : "larval development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002176",
      "lbl" : "male germ cell proliferation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population.",
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          "val" : "2010-11-18T02:35:14Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002177",
      "lbl" : "manchette",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments.",
          "xrefs" : [ "GOC:krc", "PMID:15018141", "PMID:22319670", "PMID:24440897", "PMID:26792866" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0002181",
      "lbl" : "cytoplasmic translation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.",
          "xrefs" : [ "GOC:hjd" ]
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        "comments" : [ "Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms." ],
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          "val" : "myeloid dendritic cell activation during immune response",
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002279",
      "lbl" : "mast cell activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002280",
      "lbl" : "monocyte activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002281",
      "lbl" : "macrophage activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
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          "val" : "macrophage polarization involved in immune response"
        }, {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002282",
      "lbl" : "microglial cell activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002283",
      "lbl" : "neutrophil activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
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        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002284",
      "lbl" : "myeloid dendritic cell differentiation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response.",
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        },
        "synonyms" : [ {
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          "val" : "myeloid dendritic cell differentiation during immune response",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002285",
      "lbl" : "lymphocyte activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
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          "val" : "lymphocyte activation during immune response",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002286",
      "lbl" : "T cell activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
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          "val" : "T cell activation during immune response",
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        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "T lymphocyte activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "T-cell activation during immune response"
        }, {
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          "val" : "T-lymphocyte activation during immune response"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002287",
      "lbl" : "alpha-beta T cell activation involved in immune response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
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          "val" : "alpha-beta T cell activation during immune response",
          "xrefs" : [ "GOC:tb" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "alpha-beta T lymphocyte activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "alpha-beta T-cell activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "alpha-beta T-lymphocyte activation during immune response"
        } ],
        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002292",
      "lbl" : "T cell differentiation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "T cell development involved in immune response",
          "xrefs" : [ "GOC:add" ]
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          "val" : "T cell differentiation during immune response",
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          "pred" : "hasRelatedSynonym",
          "val" : "T lymphocyte differentiation during immune response"
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          "pred" : "hasRelatedSynonym",
          "val" : "T-cell differentiation during immune response"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002302",
      "lbl" : "CD8-positive, alpha-beta T cell differentiation involved in immune response",
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        "definition" : {
          "val" : "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
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          "val" : "CD8-positive, alpha-beta T cell differentiation during immune response",
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          "val" : "CD8-positive, alpha-beta T lymphocyte differentiation during immune response"
        }, {
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          "val" : "CD8-positive, alpha-beta T-cell differentiation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "CD8-positive, alpha-beta intraepithelial T cell development",
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        } ],
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0002309",
      "lbl" : "T cell proliferation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The expansion of a T cell population by cell division as part of an immune response.",
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        },
        "synonyms" : [ {
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          "val" : "T cell proliferation during immune response",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002312",
      "lbl" : "B cell activation involved in immune response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
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          "val" : "B cell activation during immune response",
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        }, {
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          "val" : "B lymphocyte activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "B-cell activation during immune response"
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          "val" : "B-lymphocyte activation during immune response"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002313",
      "lbl" : "mature B cell differentiation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response.",
          "xrefs" : [ "GOC:jal" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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          "val" : "mature B cell differentiation during immune response",
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        }, {
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          "val" : "mature B lymphocyte differentiation during immune response"
        }, {
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          "val" : "mature B-cell differentiation during immune response"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002314",
      "lbl" : "germinal center B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA).",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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          "pred" : "hasExactSynonym",
          "val" : "germinal center B lymphocyte differentiation"
        }, {
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          "val" : "germinal center B-cell differentiation"
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          "val" : "germinal center B-lymphocyte differentiation"
        }, {
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          "val" : "germinal center B cell development",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002316",
      "lbl" : "follicular B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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          "pred" : "hasExactSynonym",
          "val" : "follicular B lymphocyte differentiation"
        }, {
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        }, {
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          "val" : "follicular B-lymphocyte differentiation"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002317",
      "lbl" : "plasma cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody.",
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        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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          "val" : "plasma cell development",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002318",
      "lbl" : "myeloid progenitor cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages.",
          "xrefs" : [ "GOC:add", "PMID:16551264" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002319",
      "lbl" : "memory B cell differentiation",
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        "definition" : {
          "val" : "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody.",
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        },
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          "val" : "memory B lymphocyte differentiation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0002320",
      "lbl" : "lymphoid progenitor cell differentiation",
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        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002321",
      "lbl" : "natural killer cell progenitor differentiation",
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        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor.",
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        }
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    }, {
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      "lbl" : "B cell proliferation involved in immune response",
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        "definition" : {
          "val" : "The expansion of a B cell population by cell division following B cell activation during an immune response.",
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        },
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      "lbl" : "natural killer cell activation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
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        },
        "synonyms" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0002324",
      "lbl" : "natural killer cell proliferation involved in immune response",
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        "definition" : {
          "val" : "The expansion of a natural killer cell population by cell division as part of an immune response.",
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        },
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      "lbl" : "natural killer cell differentiation involved in immune response",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response.",
          "xrefs" : [ "GOC:add", "PMID:11698225" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002327",
      "lbl" : "immature B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of an immature B cell.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149", "PMID:16551251" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "immature B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "immature B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "immature B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002328",
      "lbl" : "pro-B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pro-B lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pro-B cell development",
          "xrefs" : [ "GOC:add" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002329",
      "lbl" : "pre-B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "pre-B lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pre-B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002332",
      "lbl" : "transitional stage B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transitional stage B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "transitional stage B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002335",
      "lbl" : "mature B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mature B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mature B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mature cell development",
          "xrefs" : [ "GOC:add" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002337",
      "lbl" : "B-1a B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1a B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "B-1a B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002338",
      "lbl" : "B-1b B cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5.",
          "xrefs" : [ "GOC:jal", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B lymphocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B-cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1b B-lymphocyte differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "B-1b B cell development",
          "xrefs" : [ "GOC:add" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002339",
      "lbl" : "B cell selection",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte selection"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002340",
      "lbl" : "central B cell selection",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any B cell selection process that occurs in the bone marrow.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "central B lymphocyte selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central B-cell selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central B-lymphocyte selection"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002341",
      "lbl" : "central B cell anergy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "central B lymphocyte anergy"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central B-cell anergy"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "central B-lymphocyte anergy"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002343",
      "lbl" : "peripheral B cell selection",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any B cell selection process that occurs in the periphery.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "peripheral B lymphocyte selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "peripheral B-cell selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "peripheral B-lymphocyte selection"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002344",
      "lbl" : "B cell affinity maturation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen.",
          "xrefs" : [ "GOC:jal", "GO_REF:0000022", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte affinity maturation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell affinity maturation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte affinity maturation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002346",
      "lbl" : "B cell positive selection",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte positive selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell positive selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte positive selection"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002349",
      "lbl" : "histamine production involved in inflammatory response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "histamine production involved in acute inflammatory response"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002351",
      "lbl" : "serotonin production involved in inflammatory response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:16730260" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "serotonin production involved in acute inflammatory response"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002352",
      "lbl" : "B cell negative selection",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte negative selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell negative selection"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte negative selection"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002358",
      "lbl" : "B cell homeostatic proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte homeostatic proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell homeostatic proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte homeostatic proliferation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002359",
      "lbl" : "B-1 B cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The expansion of a B-1 B cell by cell division. Follows B cell activation.",
          "xrefs" : [ "GOC:jal" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B lymphocyte proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-1 B-lymphocyte proliferation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002366",
      "lbl" : "leukocyte activation involved in immune response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "immune cell activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "leucocyte activation during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "leukocyte activation during immune response",
          "xrefs" : [ "GOC:tb" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002367",
      "lbl" : "cytokine production involved in immune response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:add", "GO_REF:0000022", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "cytokine biosynthetic process involved in immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytokine production during immune response",
          "xrefs" : [ "GOC:dph" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytokine secretion during immune response",
          "xrefs" : [ "GOC:dph" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytokine secretion involved in immune response"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0002374"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0002375"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002368",
      "lbl" : "B cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that contributes to cytokine production by a B cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "B lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "B-lymphocyte cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002369",
      "lbl" : "T cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that contributes to cytokine production by a T cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "T-lymphocyte cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002370",
      "lbl" : "natural killer cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that contributes to cytokine production by a natural killer cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "NK cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002371",
      "lbl" : "dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that contributes to cytokine production by a dendritic cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002372",
      "lbl" : "myeloid dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that contributes to cytokine production by a myeloid dendritic cell.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002376",
      "lbl" : "immune system process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats.",
          "xrefs" : [ "GOC:add", "GO_REF:0000022" ]
        },
        "comments" : [ "Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501)." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Immune_system"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002377",
      "lbl" : "immunoglobulin production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "antibody production"
        }, {
          "pred" : "hasNarrowSynonym",
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          "pred" : "hasNarrowSynonym",
          "val" : "immunoglobulin secretion"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002381",
      "lbl" : "immunoglobulin production involved in immunoglobulin-mediated immune response",
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        "definition" : {
          "val" : "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels.",
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        },
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          "pred" : "hasNarrowSynonym",
          "val" : "immunoglobulin secretion involved in immune response"
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          "pred" : "hasRelatedSynonym",
          "val" : "antibody production during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "antibody secretion during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "immunoglobulin production during immune response",
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          "pred" : "hasRelatedSynonym",
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          "val" : "GO:0002380"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002384",
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        "definition" : {
          "val" : "An immune response taking place in the liver.",
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        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002385",
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        "definition" : {
          "val" : "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract.",
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        },
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          "val" : "immune response in MALT"
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          "pred" : "hasNarrowSynonym",
          "val" : "immune response in mucosal-associated lymphoid tissue"
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          "pred" : "hasNarrowSynonym",
          "val" : "immune response in urogenital tract"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002387",
      "lbl" : "immune response in gut-associated lymphoid tissue",
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        "definition" : {
          "val" : "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002388",
      "lbl" : "immune response in Peyer's patch",
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        "definition" : {
          "val" : "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine.",
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        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002395",
      "lbl" : "immune response in nasopharyngeal-associated lymphoid tissue",
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        "definition" : {
          "val" : "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002396",
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        "definition" : {
          "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002397",
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        "definition" : {
          "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002399",
      "lbl" : "MHC class II protein complex assembly",
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        "definition" : {
          "val" : "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002407",
      "lbl" : "dendritic cell chemotaxis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The movement of a dendritic cell in response to an external stimulus.",
          "xrefs" : [ "CL:0000451", "GOC:add", "ISBN:0781735149", "PMID:15814331", "PMID:16056255" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002408",
      "lbl" : "myeloid dendritic cell chemotaxis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The movement of a myeloid dendritic cell in response to an external stimulus.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002409",
      "lbl" : "Langerhans cell chemotaxis",
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        "definition" : {
          "val" : "The movement of a Langerhans cell in response to an external stimulus.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002437",
      "lbl" : "inflammatory response to antigenic stimulus",
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        "definition" : {
          "val" : "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002438",
      "lbl" : "acute inflammatory response to antigenic stimulus",
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        "definition" : {
          "val" : "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002440",
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        "definition" : {
          "val" : "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002441",
      "lbl" : "histamine secretion involved in inflammatory response",
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        "definition" : {
          "val" : "The regulated release of histamine by a cell as part of an inflammatory response.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002442",
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        "definition" : {
          "val" : "The regulated release of serotonin by a cell as part of an inflammatory response.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002443",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "leukocyte immune effector process"
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          "pred" : "hasRelatedSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002445",
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          "val" : "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors.",
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      "lbl" : "adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",
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          "val" : "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response.",
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      "lbl" : "serotonin secretion by platelet",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002720",
      "lbl" : "positive regulation of cytokine production involved in immune response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of cytokine production during immune response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of cytokine biosynthetic process involved in immune response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of cytokine secretion involved in immune response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of cytokine production during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of cytokine production during immune response",
          "xrefs" : [ "GOC:dph" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "up regulation of cytokine production during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "up-regulation of cytokine production during immune response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "upregulation of cytokine production during immune response"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0002741"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0002744"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002721",
      "lbl" : "regulation of B cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of B cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of B-lymphocyte cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002722",
      "lbl" : "negative regulation of B cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of B cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of B cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of B cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B-lymphocyte cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of B cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002723",
      "lbl" : "positive regulation of B cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of B-lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of B cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of B cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of B cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of B cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of B cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002724",
      "lbl" : "regulation of T cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of T cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of T lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of T-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of T-lymphocyte cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002725",
      "lbl" : "negative regulation of T cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of T cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of T cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of T cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of T lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of T-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of T-lymphocyte cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of T cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002726",
      "lbl" : "positive regulation of T cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of T-lymphocyte cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of T cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of T cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of T cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of T cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of T cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002727",
      "lbl" : "regulation of natural killer cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of NK cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002728",
      "lbl" : "negative regulation of natural killer cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of NK cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of natural killer cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002729",
      "lbl" : "positive regulation of natural killer cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of NK cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of natural killer cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of natural killer cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of natural killer cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002730",
      "lbl" : "regulation of dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002731",
      "lbl" : "negative regulation of dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of dendritic cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002732",
      "lbl" : "positive regulation of dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of dendritic cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002733",
      "lbl" : "regulation of myeloid dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002734",
      "lbl" : "negative regulation of myeloid dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of myeloid dendritic cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002735",
      "lbl" : "positive regulation of myeloid dendritic cell cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of myeloid dendritic cell cytokine production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of myeloid dendritic cell cytokine production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002759",
      "lbl" : "regulation of antimicrobial humoral response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response.",
          "xrefs" : [ "GOC:add" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002760",
      "lbl" : "positive regulation of antimicrobial humoral response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of antimicrobial humoral response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of antimicrobial humoral response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of antimicrobial humoral response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of antimicrobial humoral response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of antimicrobial humoral response"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002761",
      "lbl" : "regulation of myeloid leukocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation.",
          "xrefs" : [ "GOC:add" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002762",
      "lbl" : "negative regulation of myeloid leukocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of myeloid leukocyte differentiation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002763",
      "lbl" : "positive regulation of myeloid leukocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of myeloid leukocyte differentiation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of myeloid leukocyte differentiation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002775",
      "lbl" : "antimicrobial peptide production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002776",
      "lbl" : "antimicrobial peptide secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149", "PMID:11807545", "PMID:15638771" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002784",
      "lbl" : "regulation of antimicrobial peptide production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production.",
          "xrefs" : [ "GOC:add" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002785",
      "lbl" : "negative regulation of antimicrobial peptide production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of antimicrobial peptide production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of antimicrobial peptide production"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of antimicrobial peptide production"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of antimicrobial peptide production"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002790",
      "lbl" : "peptide secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The controlled release of a peptide from a cell or a tissue.",
          "xrefs" : [ "GOC:add" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002791",
      "lbl" : "regulation of peptide secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of peptide secretion.",
          "xrefs" : [ "GOC:add" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002792",
      "lbl" : "negative regulation of peptide secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of peptide secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of peptide secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of peptide secretion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of peptide secretion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002793",
      "lbl" : "positive regulation of peptide secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of peptide secretion.",
          "xrefs" : [ "GOC:add" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of peptide secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of peptide secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of peptide secretion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of peptide secretion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of peptide secretion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002794",
      "lbl" : "regulation of antimicrobial peptide secretion",
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          "val" : "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion.",
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        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002795",
      "lbl" : "negative regulation of antimicrobial peptide secretion",
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        },
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          "pred" : "hasExactSynonym",
          "val" : "down-regulation of antimicrobial peptide secretion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of antimicrobial peptide secretion"
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          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of antimicrobial peptide secretion"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002796",
      "lbl" : "positive regulation of antimicrobial peptide secretion",
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          "val" : "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion.",
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        },
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          "pred" : "hasExactSynonym",
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          "pred" : "hasNarrowSynonym",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002819",
      "lbl" : "regulation of adaptive immune response",
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        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002820",
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        },
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      "id" : "http://purl.obolibrary.org/obo/GO_0002821",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002822",
      "lbl" : "regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",
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        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002823",
      "lbl" : "negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",
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        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002824",
      "lbl" : "positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains",
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        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002825",
      "lbl" : "regulation of T-helper 1 type immune response",
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          "val" : "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response.",
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        },
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      "id" : "http://purl.obolibrary.org/obo/GO_0002826",
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          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response.",
          "xrefs" : [ "GOC:add" ]
        },
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          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of T-helper 1 type immune response"
        }, {
          "pred" : "hasNarrowSynonym",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002827",
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        "definition" : {
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        },
        "synonyms" : [ {
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          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasNarrowSynonym",
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          "pred" : "hasNarrowSynonym",
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0002828",
      "lbl" : "regulation of type 2 immune response",
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        },
        "synonyms" : [ {
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        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of Th2 immune response",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002830",
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          "pred" : "hasNarrowSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0002831",
      "lbl" : "regulation of response to biotic stimulus",
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          "xrefs" : [ "GOC:add" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
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        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
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        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "negative regulation of B lymphocyte deletion"
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          "pred" : "hasExactSynonym",
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        "definition" : {
          "val" : "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor.",
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      "lbl" : "tendon sheath development",
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          "val" : "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move.",
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        "definition" : {
          "val" : "The multiplication or reproduction of type B synoviocytes by cell division, resulting in the expansion of their population. A type B synoviocyte is a fibroblast-like cell found in synovial tissues.",
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      "lbl" : "outflow tract septum morphogenesis",
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          "val" : "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment.",
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          "val" : "2009-09-30T11:21:09Z"
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          "val" : "biological_process"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003157",
      "lbl" : "endocardium development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.",
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          "val" : "2009-10-01T12:42:27Z"
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          "val" : "biological_process"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003158",
      "lbl" : "endothelium development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.",
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          "val" : "2009-10-01T12:50:57Z"
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          "val" : "biological_process"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003159",
      "lbl" : "morphogenesis of an endothelium",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells.",
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          "val" : "2009-10-01T01:34:06Z"
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          "val" : "biological_process"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003160",
      "lbl" : "endocardium morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers.",
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          "val" : "2009-10-01T01:37:26Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003161",
      "lbl" : "cardiac conduction system development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat.",
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        "synonyms" : [ {
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          "val" : "cardiac impulse conducting system development",
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          "pred" : "hasExactSynonym",
          "val" : "heart conduction system development",
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          "val" : "2009-10-01T01:57:16Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003162",
      "lbl" : "atrioventricular node development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system.",
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          "val" : "2009-10-01T02:05:13Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003163",
      "lbl" : "sinoatrial node development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node.",
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          "val" : "SA node development",
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          "val" : "SAN development",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003164",
      "lbl" : "His-Purkinje system development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003165",
      "lbl" : "Purkinje myocyte development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003166",
      "lbl" : "bundle of His development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003167",
      "lbl" : "atrioventricular bundle cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003168",
      "lbl" : "Purkinje myocyte differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle.",
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      "lbl" : "coronary vein morphogenesis",
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        "definition" : {
          "val" : "The process in which the anatomical structures of veins of the heart are generated and organized.",
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      "lbl" : "atrioventricular valve development",
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          "val" : "The progression of the atrioventricular valve over time, from its formation to the mature structure.",
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      "lbl" : "apoptotic process involved in heart morphogenesis",
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        "definition" : {
          "val" : "Any apoptotic process that contributes to the shaping of the heart.",
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          "val" : "apoptosis involved in heart morphogenesis"
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          "val" : "2009-10-20T09:40:22Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003279",
      "lbl" : "cardiac septum development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The progression of a cardiac septum over time, from its initial formation to the mature structure.",
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          "val" : "heart septum development",
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          "val" : "2009-10-20T09:45:13Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003281",
      "lbl" : "ventricular septum development",
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        "definition" : {
          "val" : "The progression of the ventricular septum over time from its formation to the mature structure.",
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          "val" : "interventricular septum development",
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          "pred" : "hasNarrowSynonym",
          "val" : "septum inferius development",
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          "val" : "2009-10-20T10:04:51Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003283",
      "lbl" : "atrial septum development",
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        "definition" : {
          "val" : "The progression of the atrial septum over time, from its initial formation to the mature structure.",
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          "val" : "2009-10-20T10:10:38Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003292",
      "lbl" : "cardiac septum cell differentiation",
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        "definition" : {
          "val" : "The process in which an endocardial cushion cell becomes a cell of a cardiac septum.",
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          "val" : "2009-10-20T11:03:46Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003293",
      "lbl" : "heart valve cell differentiation",
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        "definition" : {
          "val" : "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve.",
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          "val" : "2009-10-20T11:06:46Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003298",
      "lbl" : "physiological muscle hypertrophy",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development.",
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          "val" : "2009-10-22T09:24:51Z"
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      "lbl" : "cardiac muscle hypertrophy",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division.",
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          "val" : "2009-10-22T10:33:56Z"
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      "lbl" : "physiological cardiac muscle hypertrophy",
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          "val" : "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003309",
      "lbl" : "type B pancreatic cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.",
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          "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin.",
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          "val" : "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.",
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      "lbl" : "heart rudiment development",
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          "val" : "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube.",
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      "lbl" : "heart rudiment morphogenesis",
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          "val" : "The process in which the anatomical structures of the heart rudiment are generated and organized.",
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      "lbl" : "heart rudiment formation",
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          "val" : "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon.",
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          "val" : "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin.",
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          "val" : "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide.",
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          "val" : "The process in which an amino acid is transported across a membrane.",
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          "val" : "2009-12-09T07:18:53Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003382",
      "lbl" : "epithelial cell morphogenesis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state.",
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          "val" : "2009-12-09T07:21:06Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003403",
      "lbl" : "optic vesicle formation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.",
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          "val" : "2009-12-21T01:42:37Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003404",
      "lbl" : "optic vesicle morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
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        "basicPropertyValues" : [ {
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          "val" : "2009-12-21T01:54:34Z"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003406",
      "lbl" : "retinal pigment epithelium development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells.",
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        "synonyms" : [ {
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          "val" : "RPE development",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
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        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-12-21T02:04:27Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003407",
      "lbl" : "neural retina development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-21T02:15:14Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003411",
      "lbl" : "cell motility involved in camera-type eye morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-21T03:04:27Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003413",
      "lbl" : "chondrocyte differentiation involved in endochondral bone morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-22T08:39:58Z"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003414",
      "lbl" : "chondrocyte morphogenesis involved in endochondral bone morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-12-22T08:42:55Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003415",
      "lbl" : "chondrocyte hypertrophy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-22T08:48:44Z"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003416",
      "lbl" : "endochondral bone growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "2009-12-22T08:52:55Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0003433",
      "lbl" : "chondrocyte development involved in endochondral bone morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb" ]
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        "basicPropertyValues" : [ {
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          "val" : "2009-12-22T12:42:44Z"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003674",
      "lbl" : "molecular_function",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.",
          "xrefs" : [ "GOC:pdt" ]
        },
        "comments" : [ "Note that, in addition to forming the root of the molecular function ontology, this term is recommended for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
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          "val" : "molecular function"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0005554"
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          "val" : "protein"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003676",
      "lbl" : "nucleic acid binding",
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        "definition" : {
          "val" : "Binding to a nucleic acid.",
          "xrefs" : [ "GOC:jl" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
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          "val" : "GO:0000496"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003677",
      "lbl" : "DNA binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).",
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
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          "val" : "plasmid binding"
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          "pred" : "hasRelatedSynonym",
          "val" : "microtubule/chromatin interaction"
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          "pred" : "hasRelatedSynonym",
          "val" : "structure specific DNA binding"
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          "pred" : "hasRelatedSynonym",
          "val" : "structure-specific DNA binding"
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      "id" : "http://purl.obolibrary.org/obo/GO_0003682",
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        "definition" : {
          "val" : "Binding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0003723",
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          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "meito sangyo OF lipase",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "steapsin",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "takedo 1969-4-9",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triacetinase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triacylglycerol acylhydrolase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triacylglycerol ester hydrolase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tributyrase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tributyrin esterase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tributyrinase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triglyceridase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triglyceride hydrolase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "triolein hydrolase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tween hydrolase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tween-hydrolyzing esterase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tweenase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "tweenesterase activity",
          "xrefs" : [ "EC:3.1.1.3" ]
        } ],
        "xrefs" : [ {
          "val" : "EC:3.1.1.3"
        }, {
          "val" : "MetaCyc:RXN-19278"
        }, {
          "val" : "RHEA:12044"
        }, {
          "val" : "Reactome:R-HSA-1482777"
        }, {
          "val" : "Reactome:R-HSA-163551"
        }, {
          "val" : "Reactome:R-HSA-5694109"
        }, {
          "val" : "Reactome:R-HSA-8848338"
        }, {
          "val" : "Reactome:R-HSA-8848339"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28176"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28339"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004888",
      "lbl" : "transmembrane signaling receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.",
          "xrefs" : [ "GOC:go_curators", "Wikipedia:Transmembrane_receptor" ]
        },
        "comments" : [ "This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "transmembrane receptor activity",
          "xrefs" : [ "GOC:bf", "GOC:signaling" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transmembrane signalling receptor activity",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-193672"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0004926"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0099600"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004896",
      "lbl" : "cytokine receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.",
          "xrefs" : [ "GOC:add", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "IL receptor"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "interleukin receptor activity",
          "xrefs" : [ "http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "hematopoietin/interferon-class (D200-domain) cytokine receptor activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0004907"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004925",
      "lbl" : "prolactin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.",
          "xrefs" : [ "GOC:mah", "GOC:signaling" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004930",
      "lbl" : "G protein-coupled receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
          "xrefs" : [ "GOC:bf", "Wikipedia:GPCR" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "G protein coupled receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G protein linked receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein linked receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GPCR activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ligand-dependent GPCR activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "receptor activity, G-protein coupled",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "EBV-induced receptor"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "Epstein-Barr Virus-induced receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein coupled receptor activity, unknown ligand"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "Mas proto-oncogene receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "RDC1 receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "SREB receptor"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "orphan G protein coupled receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "orphan G-protein coupled receptor activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "orphan GPCR activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "super conserved receptor expressed in brain receptor activity"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-114552"
        }, {
          "val" : "Reactome:R-HSA-114558"
        }, {
          "val" : "Reactome:R-HSA-167408"
        }, {
          "val" : "Reactome:R-HSA-381706"
        }, {
          "val" : "Wikipedia:GPCR"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001622"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001623"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001624"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001625"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016526"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004948",
      "lbl" : "calcitonin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
          "xrefs" : [ "GOC:mah", "GOC:signaling", "PMID:21649645" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004967",
      "lbl" : "glucagon receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
          "xrefs" : [ "GOC:mah", "GOC:signaling", "PMID:22438981" ]
        },
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-163625"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004969",
      "lbl" : "histamine receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004977",
      "lbl" : "melanocortin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with melanocortin to initiate a change in cell activity.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004978",
      "lbl" : "corticotropin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with corticotropin to initiate a change in cell activity.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ACTH receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adrenocorticotropic hormone receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adrenocorticotropin receptor activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004993",
      "lbl" : "G protein-coupled serotonin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "5-HT receptor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "5-hydroxytryptamine receptor"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G protein coupled serotonin receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled serotonin receptor activity"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:5-HT_receptor"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/12942"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001585"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016609"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0004994",
      "lbl" : "somatostatin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28).",
          "xrefs" : [ "GOC:ai", "GOC:bf", "Wikipedia:Somatostatin" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "GHIH receptor activity",
          "xrefs" : [ "Wikipedia:Somatostatin" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SRIF receptor activity",
          "xrefs" : [ "Wikipedia:Somatostatin" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SST receptor activity",
          "xrefs" : [ "Wikipedia:Somatostatin" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "growth hormone-inhibiting hormone receptor activity",
          "xrefs" : [ "Wikipedia:Somatostatin" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "somatotrophin release inhibiting factor receptor activity",
          "xrefs" : [ "Wikipedia:Somatostatin" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005000",
      "lbl" : "vasopressin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with vasopressin to initiate a change in cell activity.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "vasopressin activated calcium mobilizing receptor activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016931"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005009",
      "lbl" : "insulin receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with insulin receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "insulin-activated receptor activity"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-74715"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/23056"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28520"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005102",
      "lbl" : "signaling receptor binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.",
          "xrefs" : [ "GOC:bf", "GOC:ceb", "ISBN:0198506732" ]
        },
        "comments" : [ "Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "receptor binding"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "receptor ligand"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "receptor-associated protein activity"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Ligand_(biochemistry)"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005126",
      "lbl" : "cytokine receptor binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a cytokine receptor.",
          "xrefs" : [ "GOC:mah", "GOC:vw" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hematopoietin/interferon-class (D200-domain) cytokine receptor binding",
          "xrefs" : [ "GOC:add", "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005172",
      "lbl" : "vascular endothelial growth factor receptor binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a vascular endothelial growth factor receptor.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "VEGF receptor binding"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "VEGFR binding"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "vascular endothelial growth factor"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "vascular endothelial growth factor receptor ligand"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005173",
      "lbl" : "stem cell factor receptor binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a stem cell factor receptor (SCFR), a type III transmembrane kinase receptor.",
          "xrefs" : [ "GOC:jl", "PMID:10698217" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "SCFR binding"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "KIT binding"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "SCF"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stem cell factor"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stem cell factor receptor ligand"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005215",
      "lbl" : "transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells.",
          "xrefs" : [ "GOC:ai", "GOC:dgf" ]
        },
        "comments" : [ "Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "carrier"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/27621"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005478"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005216",
      "lbl" : "monoatomic ion channel activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the facilitated diffusion of a monoatomic ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size).",
          "xrefs" : [ "GOC:cy", "GOC:mtg_transport", "GOC:pr", "ISBN:0815340729" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "ion channel activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/24479"
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      "lbl" : "amine transmembrane transporter activity",
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          "val" : "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid.",
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          "val" : "https://github.com/geneontology/go-ontology/issues/17289"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/30193"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005488",
      "lbl" : "binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.",
          "xrefs" : [ "GOC:ceb", "GOC:mah", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "ligand"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Binding_(molecular)"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005496",
      "lbl" : "steroid binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005504",
      "lbl" : "fatty acid binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.",
          "xrefs" : [ "ISBN:0198506732" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005506",
      "lbl" : "iron ion binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to an iron (Fe) ion.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "iron binding"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005509",
      "lbl" : "calcium ion binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a calcium ion (Ca2+).",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "calcium ion storage activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005515",
      "lbl" : "protein binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a protein.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "protein amino acid binding"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "glycoprotein binding"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9866132"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001948"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0045308"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005518",
      "lbl" : "collagen binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).",
          "xrefs" : [ "GOC:ai", "ISBN:0198506732" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005524",
      "lbl" : "ATP binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Mg-ATP binding"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "MgATP binding"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-265682"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005536",
      "lbl" : "D-glucose binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to D-enantiomers of glucose.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "glucose binding"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005539",
      "lbl" : "glycosaminoglycan binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005540",
      "lbl" : "hyaluronic acid binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hyaluronan binding"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005543",
      "lbl" : "phospholipid binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a phospholipid, a class of lipids containing phosphoric acid as a mono- or diester.",
          "xrefs" : [ "ISBN:0198506732" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005548",
      "lbl" : "phospholipid transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester.",
          "xrefs" : [ "GOC:ai", "ISBN:0198506732" ]
        },
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-216757"
        }, {
          "val" : "Reactome:R-HSA-382553"
        }, {
          "val" : "Reactome:R-HSA-5678706"
        }, {
          "val" : "Reactome:R-HSA-5678749"
        }, {
          "val" : "Reactome:R-HSA-8857662"
        }, {
          "val" : "Reactome:R-HSA-8865637"
        }, {
          "val" : "Reactome:R-HSA-8867876"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008497"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005575",
      "lbl" : "cellular_component",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).",
          "xrefs" : [ "GOC:pdt" ]
        },
        "comments" : [ "Note that, in addition to forming the root of the cellular component ontology, this term is recommended for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell or subcellular entity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular component"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "subcellular entity",
          "xrefs" : [ "NIF_Subcellular:nlx_subcell_100315" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1337158144"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/17729"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008372"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "protein"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005576",
      "lbl" : "extracellular region",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "comments" : [ "Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "extracellular"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Extracellular"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005577",
      "lbl" : "fibrinogen complex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "fibrinogen"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "fibrinogen alpha chain"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "fibrinogen beta chain"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "fibrinogen gamma chain"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005581",
      "lbl" : "collagen trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures.",
          "xrefs" : [ "GOC:dos", "GOC:mah", "PMID:19693541", "PMID:21421911" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Collagen"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005583",
      "lbl" : "fibrillar collagen trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any triple helical collagen trimer that forms fibrils.",
          "xrefs" : [ "PMID:21421911" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005584",
      "lbl" : "collagen type I trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils.",
          "xrefs" : [ "PMID:21421911" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Collagen_type_I"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005585",
      "lbl" : "collagen type II trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils.",
          "xrefs" : [ "PMID:21421911" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Collagen_type_II"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005586",
      "lbl" : "collagen type III trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils.",
          "xrefs" : [ "PMID:21421911" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005587",
      "lbl" : "collagen type IV trimer",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes.",
          "xrefs" : [ "PMID:19693541", "PMID:21421911" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Collagen_type_IV"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/30148"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005604",
      "lbl" : "basement membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.",
          "xrefs" : [ "PMID:22505934", "PMID:33605520", "PMID:39223427" ]
        },
        "comments" : [ "Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "basal lamina"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "basement lamina"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "lamina densa"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Basement_membrane"
        } ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005605"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008003"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005614",
      "lbl" : "interstitial matrix",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens.",
          "xrefs" : [ "PMID:33605520", "PMID:39223427", "PMID:8450001" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005615",
      "lbl" : "extracellular space",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "comments" : [ "Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "intercellular space"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1425028079"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005622",
      "lbl" : "intracellular anatomical structure",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "internal to cell"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intracellular"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "protoplasm"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nucleocytoplasm",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "protoplast",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Intracellular"
        } ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005634",
      "lbl" : "nucleus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.",
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        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell nucleus"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "horsetail nucleus",
          "xrefs" : [ "GOC:al", "GOC:mah", "GOC:vw", "PMID:15030757" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1702920020"
        }, {
          "val" : "Wikipedia:Cell_nucleus"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005635",
      "lbl" : "nuclear envelope",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The double lipid bilayer that encloses the nucleus, separating its contents from the cytoplasm. It consists of an inner and outer nuclear membrane, with an intermembrane space (20-40 nm wide, also called the perinuclear space) between them. The envelope is supported by the nuclear lamina and contains nuclear pore complexes, which regulate molecular transport.",
          "xrefs" : [ "ISBN:0198547684", "PMID:16164970" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Nuclear_envelope"
        } ],
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          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005636"
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          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005640",
      "lbl" : "nuclear outer membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nucleus outer envelope"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "perinuclear membrane"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1617136075"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005652",
      "lbl" : "nuclear lamina",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane.",
          "xrefs" : [ "ISBN:0198506732", "ISBN:0716731363" ]
        },
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1455996588"
        }, {
          "val" : "Wikipedia:Nuclear_lamina"
        } ],
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005654",
      "lbl" : "nucleoplasm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "That part of the nuclear content other than the chromosomes or the nucleolus.",
          "xrefs" : [ "GOC:ma", "ISBN:0124325653" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
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          "val" : "NIF_Subcellular:sao661522542"
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        } ],
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005677",
      "lbl" : "chromatin silencing complex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing.",
          "xrefs" : [ "GOC:mah" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005694",
      "lbl" : "chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "comments" : [ "Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "interphase chromosome"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "prophase chromosome"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chromatid"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Chromosome"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005730",
      "lbl" : "nucleolus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1820400233"
        }, {
          "val" : "Wikipedia:Nucleolus"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005737",
      "lbl" : "cytoplasm",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Cytoplasm"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/23023"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005739",
      "lbl" : "mitochondrion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.",
          "xrefs" : [ "GOC:giardia", "ISBN:0198506732" ]
        },
        "comments" : [ "Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.)" ],
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitochondria"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1860313010"
        }, {
          "val" : "Wikipedia:Mitochondrion"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005740",
      "lbl" : "mitochondrial envelope",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space.",
          "xrefs" : [ "GOC:ai", "GOC:pz" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005743",
      "lbl" : "mitochondrial inner membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "inner mitochondrial membrane"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "inner mitochondrion membrane"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrion inner membrane"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1371347282"
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          "val" : "Wikipedia:Inner_mitochondrial_membrane"
        } ],
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005759",
      "lbl" : "mitochondrial matrix",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.",
          "xrefs" : [ "GOC:as", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrial lumen"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitochondrial stroma"
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1804523077"
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          "val" : "Wikipedia:Mitochondrial_matrix"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0031980"
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005761",
      "lbl" : "mitochondrial ribosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes.",
          "xrefs" : [ "GOC:mah", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "55S ribosome, mitochondrial"
        } ],
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005764",
      "lbl" : "lysosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.",
          "xrefs" : [ "GOC:mah", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
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          "val" : "NIF_Subcellular:sao585356902"
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          "val" : "Wikipedia:Lysosome"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005765",
      "lbl" : "lysosomal membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lysosome membrane"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005766",
      "lbl" : "primary lysosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lysosome before it has fused with a vesicle or vacuole.",
          "xrefs" : [ "GOC:jl", "ISBN:0815316194" ]
        },
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1140587416"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005773",
      "lbl" : "vacuole",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol.",
          "xrefs" : [ "GOC:mtg_sensu", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "vacuolar carboxypeptidase Y"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Vacuole"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005774",
      "lbl" : "vacuolar membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005775",
      "lbl" : "vacuolar lumen",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The volume enclosed within the vacuolar membrane.",
          "xrefs" : [ "ISBN:0198506732" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005777",
      "lbl" : "peroxisome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.",
          "xrefs" : [ "GOC:pm", "PMID:9302272", "UniProtKB-KW:KW-0576" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "peroxisome vesicle"
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          "pred" : "hasRelatedSynonym",
          "val" : "peroxisomal"
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        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao499555322"
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          "val" : "Wikipedia:Peroxisome"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005783",
      "lbl" : "endoplasmic reticulum",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).",
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      "id" : "http://purl.obolibrary.org/obo/GO_0005788",
      "lbl" : "endoplasmic reticulum lumen",
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        "definition" : {
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      "lbl" : "smooth endoplasmic reticulum",
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        "definition" : {
          "val" : "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER.",
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          "val" : "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae.",
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        "definition" : {
          "val" : "A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.",
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      "lbl" : "Golgi stack",
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        "definition" : {
          "val" : "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack.",
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          "val" : "dictyosome"
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      "id" : "http://purl.obolibrary.org/obo/GO_0005798",
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        "definition" : {
          "val" : "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell.",
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        "comments" : [ "Note that this definition includes vesicles that are transiently associated with the Golgi." ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0005811",
      "lbl" : "lipid droplet",
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        "definition" : {
          "val" : "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins.",
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        "definition" : {
          "val" : "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.",
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          "val" : "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle.",
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          "val" : "daughter centriole",
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          "val" : "MTOC"
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        "definition" : {
          "val" : "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.",
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        "definition" : {
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      "lbl" : "spindle microtubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005879",
      "lbl" : "axonemal microtubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.",
          "xrefs" : [ "GOC:cilia", "ISBN:0815316194" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005880",
      "lbl" : "nuclear microtubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any microtubule in the nucleus of a cell.",
          "xrefs" : [ "GOC:mah" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005881",
      "lbl" : "cytoplasmic microtubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any microtubule in the cytoplasm of a cell.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "non-spindle-associated astral microtubule"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005882",
      "lbl" : "intermediate filament",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins.",
          "xrefs" : [ "ISBN:0198506732", "PMID:17493611", "PMID:17551517", "PMID:7979242" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "intermediate filament associated protein"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "type I intermediate filament associated protein"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "type II intermediate filament associated protein"
        } ],
        "xrefs" : [ {
          "val" : "FMA:63851"
        }, {
          "val" : "NIF_Subcellular:sao952483289"
        }, {
          "val" : "Wikipedia:Intermediate_filament"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005884",
      "lbl" : "actin filament",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane.",
          "xrefs" : [ "GOC:mah", "ISBN:0198506732", "PMID:10666339" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "microfilament"
        } ],
        "xrefs" : [ {
          "val" : "FMA:63850"
        }, {
          "val" : "NIF_Subcellular:sao1588493326"
        }, {
          "val" : "Wikipedia:Actin"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005886",
      "lbl" : "plasma membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.",
          "xrefs" : [ "ISBN:0716731363" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "juxtamembrane"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell membrane"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular membrane",
          "xrefs" : [ "NIF_Subcellular:sao6433132645" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cytoplasmic membrane"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "plasmalemma"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "bacterial inner membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inner endospore membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "integral component of plasma membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "integral to plasma membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "plasma membrane lipid bilayer",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1663586795"
        }, {
          "val" : "Wikipedia:Cell_membrane"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005887"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0005904"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005899",
      "lbl" : "insulin receptor complex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain.",
          "xrefs" : [ "ISBN:0198506732" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005901",
      "lbl" : "caveola",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm.",
          "xrefs" : [ "GOC:mah", "ISBN:0721662544", "PMID:16645198" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "caveolae"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "caveolar membrane"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Caveolae"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016599"
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          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005902",
      "lbl" : "microvillus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "comments" : [ "Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "microvilli",
          "xrefs" : [ "NIF_Subcellular:sao671419673" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao671419673"
        }, {
          "val" : "Wikipedia:Microvillus"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005903",
      "lbl" : "brush border",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The dense covering of microvilli on the apical surface of an epithelial cell in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.",
          "xrefs" : [ "GOC:sl", "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Brush_border"
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005911",
      "lbl" : "cell-cell junction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects.",
          "xrefs" : [ "GOC:aruk", "GOC:bc", "GOC:dgh", "GOC:hb", "GOC:mah", "PMID:21422226", "PMID:28096264" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cell-cell contact region"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "cell-cell contact zone"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "intercellular junction",
          "xrefs" : [ "NIF_Subcellular:sao1395777368" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1922892319"
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        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005929",
      "lbl" : "cilium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body.",
          "xrefs" : [ "GOC:cilia", "GOC:curators", "GOC:kmv", "GOC:vw", "ISBN:0198547684", "PMID:16824949", "PMID:17009929", "PMID:20144998" ]
        },
        "comments" : [ "Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "eukaryotic flagellum"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "microtubule-based flagellum"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "primary cilium"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "flagellum"
        } ],
        "xrefs" : [ {
          "val" : "FMA:67181"
        }, {
          "val" : "NIF_Subcellular:sao787716553"
        }, {
          "val" : "Wikipedia:Cilium"
        } ],
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005930",
      "lbl" : "axoneme",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements.",
          "xrefs" : [ "GOC:bf", "GOC:cilia", "ISBN:0198547684" ]
        },
        "comments" : [ "Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ciliary axoneme"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cilium axoneme"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "flagellar axoneme"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "flagellum axoneme"
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        "xrefs" : [ {
          "val" : "Wikipedia:Axoneme"
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          "val" : "GO:0035085"
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          "val" : "GO:0035086"
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005938",
      "lbl" : "cell cortex",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins.",
          "xrefs" : [ "GOC:mah", "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "ectoplasm"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cell periphery"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "peripheral cytoplasm"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Cell_cortex"
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        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005975",
      "lbl" : "carbohydrate metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.",
          "xrefs" : [ "GOC:mah", "ISBN:0198506732" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate metabolism"
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        "xrefs" : [ {
          "val" : "Reactome:R-HSA-71387"
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          "val" : "Wikipedia:Carbohydrate_metabolism"
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          "val" : "2012-10-23T15:40:34Z"
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          "val" : "GO:0044261"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0005976",
      "lbl" : "polysaccharide metabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.",
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
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          "val" : "polysaccharide metabolism"
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          "pred" : "hasNarrowSynonym",
          "val" : "glycan metabolic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "glycan metabolism"
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          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organismal polysaccharide metabolic process"
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      "lbl" : "glycogen metabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages.",
          "xrefs" : [ "ISBN:0198506732" ]
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "glycogen formation"
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          "pred" : "hasExactSynonym",
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006264",
      "lbl" : "mitochondrial DNA replication",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which new strands of DNA are synthesized in the mitochondrion.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mtDNA replication"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "replication of mitochondrial DNA"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrial DNA synthesis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mtDNA synthesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006275",
      "lbl" : "regulation of DNA replication",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of DNA replication.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006279",
      "lbl" : "premeiotic DNA replication",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The replication of DNA that precedes meiotic cell division.",
          "xrefs" : [ "GOC:TermGenie", "GOC:ai", "GO_REF:0000060" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DNA replication involved in S phase involved in meiotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA replication involved in S-phase involved in meiotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "meiotic cell cycle DNA replication"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "meiotic nuclear cell cycle DNA replication"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "nuclear cell cycle DNA replication involved in meiotic cell cycle"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "DNA replication during S phase involved in meiotic cell cycle",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "meiotic DNA replication",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "meiotic DNA synthesis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "premeiotic DNA synthesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:1902968"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006281",
      "lbl" : "DNA repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.",
          "xrefs" : [ "PMID:11563486" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-73894"
        }, {
          "val" : "Wikipedia:DNA_repair"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006282",
      "lbl" : "regulation of DNA repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of DNA repair.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_metagenomics" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006284",
      "lbl" : "base-excision repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "BER"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-73884"
        }, {
          "val" : "Reactome:R-HSA-73930"
        }, {
          "val" : "Wikipedia:Base_excision_repair"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006298",
      "lbl" : "mismatch repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination.",
          "xrefs" : [ "ISBN:0198506732", "PMID:11687886" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "MMR"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "long patch mismatch repair system"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "MutS/MutL/MutH pathway"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mismatch repair, MutL-like pathway"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-5358508"
        }, {
          "val" : "Wikipedia:DNA_mismatch_repair"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006300"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006302",
      "lbl" : "double-strand break repair",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.",
          "xrefs" : [ "GOC:elh" ]
        },
        "comments" : [ "Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'." ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-5693532"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006308",
      "lbl" : "DNA catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "DNA breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006309",
      "lbl" : "apoptotic DNA fragmentation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:mtg_apoptosis", "GOC:tb", "ISBN:0721639976", "PMID:15723341", "PMID:23379520" ]
        },
        "comments" : [ "DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341)." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "DNA fragmentation"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "chromatinolysis",
          "xrefs" : [ "GOC:mtg_apoptosis" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA catabolic process during apoptosis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA catabolism during apoptosis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA fragmentation involved in apoptotic nuclear change",
          "xrefs" : [ "GOC:cjm", "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "endonucleolytic DNA catabolic process involved in apoptosis"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-140342"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/24396"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008178"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006310",
      "lbl" : "DNA recombination",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006325",
      "lbl" : "chromatin organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.",
          "xrefs" : [ "PMID:20404130" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "chromatin maintenance"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "chromatin organisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of chromatin architecture",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment or maintenance of chromatin architecture",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DNA replication-independent chromatin assembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DNA replication-independent chromatin organization"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DNA replication-independent nucleosome organisation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "DNA replication-independent nuclesome assembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "chromatin assembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "transcription-coupled nucleosome assembly"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chromatin assembly or disassembly"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chromatin assembly/disassembly"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chromatin modification"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-4839726"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22130"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/23549"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006333"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006336"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016568"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0031497"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0034724"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006338",
      "lbl" : "chromatin remodeling",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication.",
          "xrefs" : [ "GOC:jid", "GOC:vw", "PMID:12042764", "PMID:12697820" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chromatin modeling"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "chromatin modelling"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "chromatin remodelling"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ATP-dependent chromatin remodeling"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ATP-dependent chromatin remodelling"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/21732"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/21748"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0043044"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006349",
      "lbl" : "obsolete regulation of gene expression by genomic imprinting",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "OBSOLETE. An epigenetic mechanism of regulation of gene expression in which epigenetic modifications (imprints) are established during gametogenesis. For a given gene to show parentally biased expression, the imprint are established exclusively in one of the two parental genomes, thus generating an asymmetry between the maternal and paternal alleles.",
          "xrefs" : [ "PMID:11498578", "PMID:31896690", "PMID:7502071" ]
        },
        "comments" : [ "This term was obsoleted because it represents the same concept as its parent, GO:0071514 genomic imprinting, also a regulatory process." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of gene expression by DNA imprinting",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "regulation of gene expression by genetic imprinting"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Genomic_imprinting"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22217"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/25567"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0100001",
          "val" : "http://purl.obolibrary.org/obo/GO_0071514"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ],
        "deprecated" : true
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006351",
      "lbl" : "DNA-templated transcription",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The synthesis of an RNA transcript from a DNA template.",
          "xrefs" : [ "GOC:jl", "GOC:txnOH" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cellular transcription"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "transcription"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA-dependent transcription"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transcription, DNA-dependent",
          "xrefs" : [ "GOC:txnOH" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transcription, DNA-templated"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "bacterial transcription"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "transcription from bacterial-type RNA polymerase promoter"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-2173793"
        }, {
          "val" : "Reactome:R-HSA-74160"
        }, {
          "val" : "Wikipedia:Transcription_(genetics)"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://github.com/geneontology/go-ontology/issues/14854"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/16737"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22258"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/22555"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0001121"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006350"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0061018"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0061022"
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006355",
      "lbl" : "regulation of DNA-templated transcription",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.",
          "xrefs" : [ "GOC:go_curators", "GOC:txnOH" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "transcriptional control"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of cellular transcription, DNA-dependent"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of transcription, DNA-dependent",
          "xrefs" : [ "GOC:txnOH" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of transcription, DNA-templated"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "regulation of gene-specific transcription"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9013695"
        }, {
          "val" : "Reactome:R-HSA-9762293"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/25256"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0032583"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0045449"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0061019"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006390",
      "lbl" : "mitochondrial transcription",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase.",
          "xrefs" : [ "GOC:jl", "PMID:23632312" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "transcription from mitochondrial promoter"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-75944"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/14854"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006399",
      "lbl" : "tRNA metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pombe" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "tRNA metabolism"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006401",
      "lbl" : "RNA catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "RNA breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006403",
      "lbl" : "RNA localization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which RNA is transported to, or maintained in, a specific location.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "RNA localisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment and maintenance of RNA localization"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006404",
      "lbl" : "RNA import into nucleus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The import of RNA from the cytoplasm to the nucleus.",
          "xrefs" : [ "GOC:ma" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "RNA import into cell nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA transport from cytoplasm to nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA-nucleus import"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006405",
      "lbl" : "RNA export from nucleus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of RNA from the nucleus to the cytoplasm.",
          "xrefs" : [ "GOC:ma" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "RNA export from cell nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA export out of nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA transport from nucleus to cytoplasm"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "RNA-nucleus export"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006409",
      "lbl" : "tRNA export from nucleus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of tRNA from the nucleus to the cytoplasm.",
          "xrefs" : [ "GOC:ma" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "tRNA export from cell nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tRNA export out of nucleus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tRNA transport from nucleus to cytoplasm"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "tRNA-nucleus export"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006412",
      "lbl" : "translation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "protein translation"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-72766"
        }, {
          "val" : "Wikipedia:Translation_(genetics)"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006416"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006453"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0043037"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "protein"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006413",
      "lbl" : "translational initiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.",
          "xrefs" : [ "ISBN:019879276X" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "biopolymerisation"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "biopolymerization"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "protein synthesis initiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "translation initiation"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-72613"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006440"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006454"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006414",
      "lbl" : "translational elongation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis.",
          "xrefs" : [ "GOC:ems" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "protein synthesis elongation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "translation elongation"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-156842"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006442"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006455"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006415",
      "lbl" : "translational termination",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).",
          "xrefs" : [ "GOC:hjd", "ISBN:019879276X" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "protein synthesis termination"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "translation termination"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "translational complex disassembly"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-72764"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006443"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006456"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006417",
      "lbl" : "regulation of translation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.",
          "xrefs" : [ "GOC:isa_complete" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of protein anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of protein biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of protein formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of protein synthesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006445"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006446",
      "lbl" : "regulation of translational initiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of translational initiation.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006448",
      "lbl" : "regulation of translational elongation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, extent or accuracy of translational elongation.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006449",
      "lbl" : "regulation of translational termination",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of translational termination.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006468",
      "lbl" : "protein phosphorylation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process of introducing a phosphate group on to a protein.",
          "xrefs" : [ "GOC:hb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "protein amino acid phosphorylation",
          "xrefs" : [ "GOC:bf" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006469",
      "lbl" : "negative regulation of protein kinase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of protein kinase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of protein kinase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of protein kinase activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of protein kinase activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006508",
      "lbl" : "proteolysis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.",
          "xrefs" : [ "GOC:bf", "GOC:mah" ]
        },
        "comments" : [ "This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "peptidolysis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ATP-dependent proteolysis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Proteolysis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006516",
      "lbl" : "glycoprotein catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of a glycoprotein, a protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glycoprotein breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glycoprotein catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glycoprotein degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006518",
      "lbl" : "peptide metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "peptide metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-2980736"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006520",
      "lbl" : "amino acid metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cellular amino acid metabolic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular amino acid metabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "amino acid and derivative metabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cellular amino acid and derivative metabolic process"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://github.com/geneontology/go-ontology/issues/17904"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006519"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006521",
      "lbl" : "regulation of amino acid metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids.",
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          "val" : "The chemical reactions and pathways resulting in the breakdown of L-tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid.",
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      "lbl" : "acetylcholine catabolic process",
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          "val" : "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline.",
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          "xrefs" : [ "GOC:jl", "ISBN:0198506732", "Wikipedia:Porphyrin#Natural_formation" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin metabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-189445"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006779",
      "lbl" : "porphyrin-containing compound biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732", "Wikipedia:Porphyrin#Natural_formation" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin anabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin biosynthesis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin biosynthetic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin formation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006787",
      "lbl" : "porphyrin-containing compound catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin breakdown"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin catabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin catabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "porphyrin degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006790",
      "lbl" : "sulfur compound metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "sulfur metabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sulphur metabolic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sulphur metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Sulfur_metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006793",
      "lbl" : "phosphorus metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "phosphorus metabolism"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006796",
      "lbl" : "phosphate-containing compound metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "phosphate metabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "phosphate metabolic process"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006805",
      "lbl" : "xenobiotic metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.",
          "xrefs" : [ "GOC:cab2", "GOC:krc" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "xenobiotic metabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "drug metabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "drug metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-211859"
        }, {
          "val" : "Reactome:R-HSA-211981"
        }, {
          "val" : "Reactome:R-HSA-2161541"
        }, {
          "val" : "Reactome:R-HSA-9748784"
        }, {
          "val" : "Wikipedia:Drug_metabolism"
        }, {
          "val" : "Wikipedia:Xenobiotic_metabolism"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/19460"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0017144"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006810",
      "lbl" : "transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or a transporter complex, a pore or a motor protein.",
          "xrefs" : [ "GOC:dos", "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "comments" : [ "Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "single-organism transport"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-382551"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/20292"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "jl"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-12-13T16:25:32Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015457"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015460"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044765"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006811",
      "lbl" : "monoatomic ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "ion transport"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-425393"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006812",
      "lbl" : "monoatomic cation transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cation transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "di-, tri-valent inorganic cation transport",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "trivalent inorganic cation transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006819"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015674"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0072512"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006813",
      "lbl" : "potassium ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "sodium/potassium transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular potassium ion transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "potassium conductance"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "potassium ion conductance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "K+ conductance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "low voltage-dependent potassium channel auxiliary protein activity",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "low voltage-gated potassium channel auxiliary protein activity",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "potassium transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "mah"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-09-03T02:39:22Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015458"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0071804"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006814",
      "lbl" : "sodium ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "sodium/potassium transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sodium transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitochondrial sodium/calcium ion exchange"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "sodium:calcium exchange"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "sodium:solute transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "sodium channel auxiliary protein activity",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006834"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016974"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006816",
      "lbl" : "calcium ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "calcium transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "mitochondrial sodium/calcium ion exchange"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "sodium:calcium exchange"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006817",
      "lbl" : "phosphate ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of phosphate ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "phosphate transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006820",
      "lbl" : "monoatomic anion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a monoatomic anion, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "anion transport"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0006822"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006821",
      "lbl" : "chloride transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006826",
      "lbl" : "iron ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "iron transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferric ion import"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferric ion transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferric iron import"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferric iron transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferric iron uptake"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferrous ion transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ferrous iron transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "iron ion import"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2012-04-18T03:33:45Z"
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          "val" : "GO:0097286"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006833",
      "lbl" : "water transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "xrefs" : [ {
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      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
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        "synonyms" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006836",
      "lbl" : "neurotransmitter transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.",
          "xrefs" : [ "GOC:ai" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
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          "val" : "Reactome:R-HSA-212676"
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      "lbl" : "regulation of pH",
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          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell.",
          "xrefs" : [ "GOC:jl", "PMID:12598593" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hypo-osmotic response"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006974",
      "lbl" : "DNA damage response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "response to DNA damage stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular DNA damage response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular response to DNA damage stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "response to genotoxic stress"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/24775"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0034984"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006979",
      "lbl" : "response to oxidative stress",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.",
          "xrefs" : [ "GOC:jl", "PMID:12115731" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006996",
      "lbl" : "organelle organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.",
          "xrefs" : [ "GOC:mah" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "organelle organisation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "single organism organelle organization",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "organelle organization and biogenesis",
          "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single-organism organelle organization"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-1852241"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/27189"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "jl"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2013-12-19T15:25:51Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:1902589"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006997",
      "lbl" : "nucleus organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus.",
          "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nuclear organisation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "nuclear organization"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nuclear morphology"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nuclear organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nucleus organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0048287"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0006998",
      "lbl" : "nuclear envelope organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope.",
          "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:jl", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nuclear envelope organisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nuclear envelope organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007000",
      "lbl" : "nucleolus organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus.",
          "xrefs" : [ "GOC:dph", "GOC:jid", "GOC:jl", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nucleolus organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nucleolus organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007005",
      "lbl" : "mitochondrion organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components.",
          "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah", "GOC:sgd_curators", "PMID:9786946" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitochondria organization",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrial biogenesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrial organization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrion biogenesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrion organisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrion morphogenesis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrion organization and biogenesis"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-1592230"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007006",
      "lbl" : "mitochondrial membrane organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion.",
          "xrefs" : [ "GOC:ai", "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mitochondrial membrane organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrial membrane organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007009",
      "lbl" : "plasma membrane organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.",
          "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "plasma membrane organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "plasma membrane organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007010",
      "lbl" : "cytoskeleton organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures.",
          "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cytoskeleton organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytoskeletal organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytoskeletal regulator activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytoskeleton organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007015",
      "lbl" : "actin filament organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "actin filament organisation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of actin filament localization"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007017",
      "lbl" : "microtubule-based process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/19809"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007018",
      "lbl" : "microtubule-based movement",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules.",
          "xrefs" : [ "GOC:cjm", "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic" ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-983189"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007019",
      "lbl" : "microtubule depolymerization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The removal of tubulin heterodimers from one or both ends of a microtubule.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "microtubule disassembly"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "microtubule shortening"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "microtubule catastrophe",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "microtubule depolymerization during nuclear congression"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007020",
      "lbl" : "microtubule nucleation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation).",
          "xrefs" : [ "GOC:go_curators", "ISBN:0815316194", "PMID:12517712" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Microtubule_nucleation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007026",
      "lbl" : "negative regulation of microtubule depolymerization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.",
          "xrefs" : [ "GOC:mah", "ISBN:0815316194" ]
        },
        "synonyms" : [ {
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          "val" : "down regulation of microtubule depolymerization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of microtubule depolymerization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of microtubule depolymerization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "microtubule stabilization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of microtubule disassembly"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of microtubule depolymerization"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "microtubule rescue",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of microtubule catastrophe",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007027",
      "lbl" : "negative regulation of axonemal microtubule depolymerization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme.",
          "xrefs" : [ "GOC:dph", "GOC:mah" ]
        },
        "synonyms" : [ {
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          "val" : "axonemal microtubule stabilization"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of microtubule depolymerization in axoneme",
          "xrefs" : [ "GOC:dph" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007028",
      "lbl" : "cytoplasm organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.",
          "xrefs" : [ "GOC:curators", "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cytoplasm organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cytoplasm organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007030",
      "lbl" : "Golgi organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus.",
          "xrefs" : [ "GOC:dph", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Golgi apparatus organization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "Golgi organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Golgi organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007031",
      "lbl" : "peroxisome organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "peroxisome organisation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "peroxisome organization and biogenesis",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007033",
      "lbl" : "vacuole organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
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          "val" : "vacuole organisation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "vacuolar assembly",
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          "pred" : "hasRelatedSynonym",
          "val" : "establishment of cell nucleus localization"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment of localization of nucleus"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment of nucleus localisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment of nucleus localization"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0040023"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007112",
      "lbl" : "male meiosis cytokinesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cytokinesis after male meiosis",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cytokinesis involved in male meiotic cell cycle",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007113",
      "lbl" : "endomitotic cell cycle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell.",
          "xrefs" : [ "GOC:curators", "GOC:dos", "GOC:expert_vm" ]
        },
        "comments" : [ "Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "endomitosis"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Mitosis#Endomitosis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007135",
      "lbl" : "meiosis II",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "ISBN:0198547684" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "meiosis II nuclear division"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Meiosis#Meiosis_II"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007140",
      "lbl" : "male meiotic nuclear division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:vw" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "male nuclear division"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "male meiosis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007142",
      "lbl" : "male meiosis II",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline.",
          "xrefs" : [ "GOC:dph", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "male meiosis II nuclear division"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007143",
      "lbl" : "female meiotic nuclear division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline.",
          "xrefs" : [ "GOC:dph", "GOC:ems", "GOC:mah", "GOC:vw" ]
        },
        "comments" : [ "Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "female meiosis"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "female meiotic division"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007147",
      "lbl" : "female meiosis II",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cell cycle process in which the second meiotic division occurs in the female germline.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "female meiosis II nuclear division"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007154",
      "lbl" : "cell communication",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "xrefs" : [ {
          "val" : "Wikipedia:Cell_signaling"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007155",
      "lbl" : "cell adhesion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.",
          "xrefs" : [ "GOC:hb", "GOC:pf" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cell adhesion molecule activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single organism cell adhesion"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Cell_adhesion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "dos"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2014-04-15T15:59:10Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0098602"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007159",
      "lbl" : "leukocyte cell-cell adhesion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The attachment of a leukocyte to another cell via adhesion molecules.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "leukocyte adhesion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "leukocyte cell adhesion"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007162",
      "lbl" : "negative regulation of cell adhesion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of cell adhesion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of cell adhesion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of cell adhesion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of cell adhesion"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cell adhesion receptor inhibitor activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007163",
      "lbl" : "establishment or maintenance of cell polarity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cell polarity",
          "xrefs" : [ "GOC:mah", "GOC:vw" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment and/or maintenance of cell polarity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment and/or maintenance of cell polarization"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0030012"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0030467"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007165",
      "lbl" : "signal transduction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.",
          "xrefs" : [ "GOC:go_curators", "GOC:mtg_signaling_feb11" ]
        },
        "comments" : [ "Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "signaling cascade"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "signalling cascade"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "signaling pathway"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "signalling pathway"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-212718"
        }, {
          "val" : "Wikipedia:Signal_transduction"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0023014"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0023015"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0023016"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0023033"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0023045"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007166",
      "lbl" : "cell surface receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.",
          "xrefs" : [ "GOC:signaling" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell surface receptor linked signal transduction"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell surface receptor linked signaling pathway",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell surface receptor linked signalling pathway",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-73887"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007167",
      "lbl" : "enzyme-linked receptor protein signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with the regulation of a downstream cellular process, e.g. transcription.",
          "xrefs" : [ "GOC:mah", "GOC:signaling", "ISBN:0815316194" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "enzyme linked receptor protein signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "enzyme linked receptor protein signalling pathway"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007169",
      "lbl" : "cell surface receptor protein tyrosine kinase signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.",
          "xrefs" : [ "GOC:ceb", "GOC:signaling" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "transmembrane receptor protein serine/threonine kinase signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transmembrane receptor protein tyrosine kinase signalling pathway"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-187015"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/26955"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007186",
      "lbl" : "G protein-coupled receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane.",
          "xrefs" : [ "GOC:bf", "GOC:mah", "PMID:16902576", "PMID:24568158", "Wikipedia:G_protein-coupled_receptor" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "G protein coupled receptor protein signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G protein coupled receptor protein signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled receptor protein signal transduction"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled receptor protein signaling pathway",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled receptor signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "G-protein-coupled receptor protein signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GPCR signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GPCR signalling pathway"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "G-protein coupled receptor signaling pathway via GPCR dimer",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "dimeric G-protein coupled receptor signaling pathway"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "dimeric G-protein coupled receptor signalling pathway",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-373076"
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          "val" : "Reactome:R-HSA-388396"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0038042"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007204",
      "lbl" : "positive regulation of cytosolic calcium ion concentration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the concentration of calcium ions in the cytosol.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "cytoplasmic calcium ion concentration elevation"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "elevation of calcium ion concentration in cytoplasm"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "elevation of cytoplasmic calcium ion concentration"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cytosolic calcium ion concentration elevation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "elevation of calcium ion concentration in cytosol"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "elevation of cytosolic calcium ion concentration"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007213",
      "lbl" : "G protein-coupled acetylcholine receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription.",
          "xrefs" : [ "GOC:mah", "ISBN:0815316194" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled acetylcholine receptor signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine receptor signalling, muscarinic pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "muscarinic acetylcholine receptor signaling pathway",
          "xrefs" : [ "GOC:bf" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007214",
      "lbl" : "gamma-aminobutyric acid signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutanoate signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutanoate signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutyrate signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutyrate signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GABA signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GABA signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "gamma-aminobutyric acid signalling pathway"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007215",
      "lbl" : "glutamate receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals initiated by the binding of glutamate to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.",
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          "val" : "glutamate signalling pathway"
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      "lbl" : "G protein-coupled glutamate receptor signaling pathway",
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        "definition" : {
          "val" : "A G protein-coupled receptor signaling pathway initiated by glutamate binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.",
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          "val" : "metabotropic glutamate receptor signalling pathway"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007218",
      "lbl" : "neuropeptide signaling pathway",
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          "val" : "A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007267",
      "lbl" : "cell-cell signaling",
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          "val" : "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.",
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      "lbl" : "chemical synaptic transmission",
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          "val" : "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.",
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          "val" : "Reactome:R-HSA-451307"
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          "val" : "Reactome:R-HSA-451308"
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          "val" : "Reactome:R-HSA-9619229"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007269",
      "lbl" : "neurotransmitter secretion",
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        "definition" : {
          "val" : "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission.",
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          "pred" : "hasExactSynonym",
          "val" : "neurotransmitter secretory pathway"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007271",
      "lbl" : "synaptic transmission, cholinergic",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.",
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          "val" : "cholinergic synaptic transmission"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007272",
      "lbl" : "ensheathment of neurons",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment.",
          "xrefs" : [ "GOC:dgh", "GOC:dph", "GOC:tb" ]
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        "synonyms" : [ {
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          "val" : "ionic insulation of neurons by glial cells"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007274",
      "lbl" : "neuromuscular synaptic transmission",
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        "definition" : {
          "val" : "The process of synaptic transmission from a neuron to a muscle, across a synapse.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007275",
      "lbl" : "multicellular organism development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).",
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        },
        "comments" : [ "Note that this term was 'developmental process'." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0007276",
      "lbl" : "gamete generation",
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        "definition" : {
          "val" : "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007281",
      "lbl" : "germ cell development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism.",
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          "val" : "primordial germ cell development"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007283",
      "lbl" : "spermatogenesis",
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        "definition" : {
          "val" : "The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007284",
      "lbl" : "spermatogonial cell division",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes).",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007285",
      "lbl" : "primary spermatocyte growth",
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        "definition" : {
          "val" : "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007286",
      "lbl" : "spermatid development",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure.",
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        "synonyms" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0007288",
      "lbl" : "sperm axoneme assembly",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007289",
      "lbl" : "spermatid nucleus differentiation",
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        "definition" : {
          "val" : "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization.",
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          "val" : "spermatid nuclear differentiation"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007291",
      "lbl" : "sperm individualization",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007292",
      "lbl" : "female gamete generation",
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        "definition" : {
          "val" : "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007293",
      "lbl" : "germarium-derived egg chamber formation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007308",
      "lbl" : "oocyte construction",
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        "definition" : {
          "val" : "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster.",
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          "val" : "oocyte arrangement",
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      "lbl" : "oocyte axis specification",
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        "definition" : {
          "val" : "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster.",
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      "lbl" : "oocyte anterior/posterior axis specification",
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        "definition" : {
          "val" : "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007320",
      "lbl" : "insemination",
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        "definition" : {
          "val" : "The introduction of semen or sperm into the genital tract of a female.",
          "xrefs" : [ "ISBN:0582227089" ]
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        "xrefs" : [ {
          "val" : "Wikipedia:Insemination"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007338",
      "lbl" : "single fertilization",
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        "definition" : {
          "val" : "The union of male and female gametes to form a zygote.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007339",
      "lbl" : "binding of sperm to zona pellucida",
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        "definition" : {
          "val" : "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place.",
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        "definition" : {
          "val" : "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.",
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          "val" : "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007343",
      "lbl" : "egg activation",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007507",
      "lbl" : "heart development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.",
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          "val" : "dorsal vessel development"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007517",
      "lbl" : "muscle organ development",
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          "val" : "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007519",
      "lbl" : "skeletal muscle tissue development",
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        "definition" : {
          "val" : "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007520",
      "lbl" : "myoblast fusion",
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          "val" : "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007528",
      "lbl" : "neuromuscular junction development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction.",
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          "val" : "neuromuscular junction organization"
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          "val" : "NMJ stability",
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          "pred" : "hasRelatedSynonym",
          "val" : "neuromuscular junction stability",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007530",
      "lbl" : "sex determination",
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        "definition" : {
          "val" : "Any process that establishes and transmits the specification of sexual status of an individual organism.",
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          "val" : "Wikipedia:Sex-determination_system"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007538",
      "lbl" : "primary sex determination",
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        "definition" : {
          "val" : "The sex determination process that results in the initial specification of sexual status of an individual organism.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007548",
      "lbl" : "sex differentiation",
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        "definition" : {
          "val" : "The establishment of the sex of an organism by physical differentiation.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007549",
      "lbl" : "sex-chromosome dosage compensation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes.",
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          "val" : "dosage compensation"
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          "pred" : "hasExactSynonym",
          "val" : "sex chromosome dosage compensation"
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          "val" : "Wikipedia:Sex-chromosome_dosage_compensation"
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        "basicPropertyValues" : [ {
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          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007565",
      "lbl" : "female pregnancy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth.",
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          "pred" : "hasExactSynonym",
          "val" : "gestation"
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          "pred" : "hasRelatedSynonym",
          "val" : "carrying of young"
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          "val" : "Wikipedia:Gestation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007566",
      "lbl" : "embryo implantation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Attachment of the blastocyst to the uterine lining.",
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          "pred" : "hasExactSynonym",
          "val" : "blastocyst implantation"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007567",
      "lbl" : "parturition",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "giving birth"
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          "pred" : "hasNarrowSynonym",
          "val" : "egg laying"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007584",
      "lbl" : "response to nutrient",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.",
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        "synonyms" : [ {
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          "val" : "response to nutrients"
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          "pred" : "hasNarrowSynonym",
          "val" : "nutritional response pathway"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007585",
      "lbl" : "respiratory gaseous exchange by respiratory system",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms.",
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          "val" : "breathing"
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          "pred" : "hasBroadSynonym",
          "val" : "respiration"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007586",
      "lbl" : "digestion",
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        "definition" : {
          "val" : "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007588",
      "lbl" : "excretion",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.",
          "xrefs" : [ "ISBN:0192801023" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007589",
      "lbl" : "body fluid secretion",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The controlled release of a fluid by a cell or tissue in an animal.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007595",
      "lbl" : "lactation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007596",
      "lbl" : "blood coagulation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.",
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        },
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          "val" : "blood clotting"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007599",
      "lbl" : "hemostasis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0007600",
      "lbl" : "sensory perception",
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          "val" : "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.",
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        "synonyms" : [ {
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          "val" : "sense of sight"
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      "lbl" : "sensory perception of sound",
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        "definition" : {
          "val" : "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound.",
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        "synonyms" : [ {
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          "val" : "hearing"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007606",
      "lbl" : "sensory perception of chemical stimulus",
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          "val" : "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process.",
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      "lbl" : "sensory perception of smell",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process.",
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      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity.",
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        },
        "comments" : [ "1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis)." ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0007611",
      "lbl" : "learning or memory",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The acquisition and processing of information and/or the storage and retrieval of this information over time.",
          "xrefs" : [ "GOC:jid", "PMID:8938125" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007612",
      "lbl" : "learning",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.",
          "xrefs" : [ "ISBN:0582227089", "ISBN:0721662544" ]
        },
        "xrefs" : [ {
          "val" : "Wikipedia:Learning"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007613",
      "lbl" : "memory",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task).",
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        },
        "xrefs" : [ {
          "val" : "Wikipedia:Memory"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007617",
      "lbl" : "mating behavior",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes.",
          "xrefs" : [ "GOC:ai", "GOC:dph" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mating behaviour"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Mating_behaviour"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007620",
      "lbl" : "copulation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The act of sexual union between male and female, involving the transfer of sperm.",
          "xrefs" : [ "ISBN:0721662544" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007622",
      "lbl" : "rhythmic behavior",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The specific behavior of an organism that recur with measured regularity.",
          "xrefs" : [ "GOC:jl", "GOC:pr" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "rhythmic behavioral response to stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "rhythmic behaviour"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "rhythmic behavioural response to stimulus"
        } ],
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007623",
      "lbl" : "circadian rhythm",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any biological process in an organism that recurs with a regularity of approximately 24 hours.",
          "xrefs" : [ "GOC:bf", "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ],
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          "pred" : "hasExactSynonym",
          "val" : "circadian process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "circadian response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "response to circadian rhythm"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-400253"
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          "val" : "Wikipedia:Circadian_rhythm"
        } ],
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          "val" : "GO:0050895"
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007626",
      "lbl" : "locomotory behavior",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions.",
          "xrefs" : [ "GOC:dph" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "behavior via locomotion"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "locomotion in response to stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "locomotory behavioral response to stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "locomotory behaviour"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "locomotory behavioural response to stimulus"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007631",
      "lbl" : "feeding behavior",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Behavior associated with the intake of food.",
          "xrefs" : [ "GOC:mah" ]
        },
        "comments" : [ "See also the biological process term 'behavior ; GO:0007610'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "behavioral response to food"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "behavioural response to food"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "feeding behaviour"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "eating"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding from phloem of other organism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding from plant phloem"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding from tissue of other organism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding from vascular tissue of another organism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding from xylem of other organism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding on or from other organism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "feeding on plant sap"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:List_of_feeding_behaviours"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "jl"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2011-10-27T03:53:33Z"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044366"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044367"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044368"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044369"
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          "val" : "GO:0044370"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044371"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044372"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0007632",
      "lbl" : "visual behavior",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The behavior of an organism in response to a visual stimulus.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "behavioral response to visual stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "behavioural response to visual stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "visual behaviour"
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      "id" : "http://purl.obolibrary.org/obo/GO_0007638",
      "lbl" : "mechanosensory behavior",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Behavior that is dependent upon the sensation of a mechanical stimulus.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "behavioral response to mechanical stimulus"
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          "pred" : "hasExactSynonym",
          "val" : "behavioural response to mechanical stimulus"
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0008015",
      "lbl" : "blood circulation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products.",
          "xrefs" : [ "GOC:mtg_heart", "ISBN:0192800825" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "hemolymph circulation"
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          "val" : "GO:0070261"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008016",
      "lbl" : "regulation of heart contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body.",
          "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:tb" ]
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        "synonyms" : [ {
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          "val" : "regulation of cardiac contraction"
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      "id" : "http://purl.obolibrary.org/obo/GO_0008017",
      "lbl" : "microtubule binding",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Binding to a microtubule, a filament composed of tubulin monomers.",
          "xrefs" : [ "GOC:krc" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "microtubule severing activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "microtubule/chromatin interaction"
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        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9614343"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008021",
      "lbl" : "synaptic vesicle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.",
          "xrefs" : [ "PMID:10099709", "PMID:12563290" ]
        },
        "comments" : [ "This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles." ],
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        "synonyms" : [ {
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          "val" : "docked vesicle",
          "xrefs" : [ "NIF_Subcellular:sao403156667" ]
        } ],
        "xrefs" : [ {
          "val" : "NIF_Subcellular:sao1071221672"
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          "val" : "Wikipedia:Synaptic_vesicle"
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        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008028",
      "lbl" : "monocarboxylic acid transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "monocarboxylate carrier"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "prostaglandin/thromboxane transporter activity"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-429749"
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          "val" : "Reactome:R-HSA-433698"
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          "val" : "Reactome:R-HSA-5624211"
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          "val" : "Reactome:R-HSA-9645220"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0008505"
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      "id" : "http://purl.obolibrary.org/obo/GO_0008037",
      "lbl" : "cell recognition",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a cell in an organism interprets its surroundings.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
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          "val" : "recognition of surroundings by cell"
        } ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0008038",
      "lbl" : "neuron recognition",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a neuronal cell in a multicellular organism interprets its surroundings.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "neuronal cell recognition"
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      "id" : "http://purl.obolibrary.org/obo/GO_0008045",
      "lbl" : "motor neuron axon guidance",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues.",
          "xrefs" : [ "CL:0000100", "GOC:pr", "ISBN:0878932437" ]
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        "synonyms" : [ {
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          "val" : "motoneuron axon guidance"
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          "pred" : "hasExactSynonym",
          "val" : "motor axon guidance"
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          "pred" : "hasExactSynonym",
          "val" : "motor axon pathfinding",
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      "id" : "http://purl.obolibrary.org/obo/GO_0008066",
      "lbl" : "glutamate receptor activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.",
          "xrefs" : [ "GOC:ai", "GOC:signaling" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008078",
      "lbl" : "mesodermal cell migration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The orderly movement of mesodermal cells from one site to another.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:mah", "GOC:sat", "GOC:tb", "PMID:25119047" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mesoderm cell migration"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008088",
      "lbl" : "axo-dendritic transport",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The directed movement of organelles or molecules along microtubules in neuron projections.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "axon cargo transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "axonal transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "axoplasmic transport"
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        "xrefs" : [ {
          "val" : "Wikipedia:Axoplasmic_transport"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008089",
      "lbl" : "anterograde axonal transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons.",
          "xrefs" : [ "ISBN:0815316194" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ],
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008090",
      "lbl" : "retrograde axonal transport",
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        "definition" : {
          "val" : "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons.",
          "xrefs" : [ "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_synapse" ],
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008092",
      "lbl" : "cytoskeletal protein binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a protein component of a cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton).",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_yeast" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008094",
      "lbl" : "ATP-dependent activity, acting on DNA",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalytic activity that acts to modify DNA, driven by ATP hydrolysis.",
          "xrefs" : [ "GOC:pdt" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ATPase activity, acting on DNA"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ATPase, acting on DNA"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA dependent ATPase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA-dependent ATPase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA-dependent adenosinetriphosphatase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "adenosinetriphosphatase (DNA-dependent)"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/20876"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/21612"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/21775"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0004011"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008104",
      "lbl" : "intracellular protein localization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which a protein is transported to, or maintained in, a specific location.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_drosophila" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "protein localization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular protein localisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular protein localization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "protein localisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "channel localizer activity",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "asymmetric protein localisation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "asymmetric protein localization"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment and maintenance of asymmetric protein localization"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "establishment and maintenance of protein localization"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9609507"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008105"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016249"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0034613"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008112",
      "lbl" : "nicotinamide N-methyltransferase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine.",
          "xrefs" : [ "EC:2.1.1.1", "RHEA:23884" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity",
          "xrefs" : [ "EC:2.1.1.1" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "nicotinamide methyltransferase activity",
          "xrefs" : [ "EC:2.1.1.1" ]
        } ],
        "xrefs" : [ {
          "val" : "EC:2.1.1.1"
        }, {
          "val" : "KEGG_REACTION:R01269"
        }, {
          "val" : "MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN"
        }, {
          "val" : "RHEA:23884"
        }, {
          "val" : "Reactome:R-HSA-5359451"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008119",
      "lbl" : "thiopurine S-methyltransferase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether.",
          "xrefs" : [ "EC:2.1.1.67" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "6-thiopurine transmethylase activity",
          "xrefs" : [ "EC:2.1.1.67" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity",
          "xrefs" : [ "EC:2.1.1.67" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "TPMT",
          "xrefs" : [ "EC:2.1.1.67" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mercaptopurine methyltransferase activity",
          "xrefs" : [ "EC:2.1.1.67" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "thiopurine methyltransferase activity",
          "xrefs" : [ "EC:2.1.1.67" ]
        } ],
        "xrefs" : [ {
          "val" : "EC:2.1.1.67"
        }, {
          "val" : "MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN"
        }, {
          "val" : "Reactome:R-HSA-158609"
        }, {
          "val" : "Reactome:R-HSA-5603379"
        }, {
          "val" : "Reactome:R-HSA-9748979"
        }, {
          "val" : "Reactome:R-HSA-9748983"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008134",
      "lbl" : "transcription factor binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a transcription factor, a protein required to initiate or regulate transcription.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "comments" : [ "Note that this term should not be used for direct annotation. Please consider one of the more specific descendants, GO:0140297 ; DNA-binding transcription factor binding, GO:0140296 ; general transcription initiation factor binding or GO:0001221 ; transcription coregulator binding." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "TF binding"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "transcription regulator binding"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://github.com/geneontology/go-ontology/issues/19354"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008150",
      "lbl" : "biological_process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.",
          "xrefs" : [ "GOC:pdt" ]
        },
        "comments" : [ "Note that, in addition to forming the root of the biological process ontology, this term is recommended for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code 'no data' (ND), is used to indicate this." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_pombe", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "biological process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "physiological process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single organism process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single-organism process"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Biological_process"
        } ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "jl"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-09-19T15:05:24Z"
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          "val" : "GO:0000004"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0007582"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044699"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "protein"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008152",
      "lbl" : "metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0198547684" ]
        },
        "comments" : [ "Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "metabolism"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-1430728"
        }, {
          "val" : "Wikipedia:Metabolism"
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        "basicPropertyValues" : [ {
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          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28932"
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          "val" : "GO:0044236"
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          "val" : "GO:0044710"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008156",
      "lbl" : "negative regulation of DNA replication",
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        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of DNA replication"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of DNA replication"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of DNA replication"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of DNA replication"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "DNA replication inhibitor"
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        "basicPropertyValues" : [ {
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
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          "pred" : "hasBroadSynonym",
          "val" : "methylase"
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        "xrefs" : [ {
          "val" : "EC:2.1.1.-"
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          "val" : "Reactome:R-HSA-212269"
        }, {
          "val" : "Reactome:R-HSA-379387"
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          "val" : "Reactome:R-HSA-379464"
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          "val" : "Reactome:R-HSA-6800149"
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          "val" : "Reactome:R-HSA-71286"
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          "val" : "GO:0004480"
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      "id" : "http://purl.obolibrary.org/obo/GO_0008170",
      "lbl" : "N-methyltransferase activity",
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        "definition" : {
          "val" : "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule.",
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          "val" : "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.",
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        },
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          "val" : "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0008188",
      "lbl" : "neuropeptide receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with a neuropeptide to initiate a change in cell activity.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0008202",
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        "xrefs" : [ {
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        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0008203",
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      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues.",
          "xrefs" : [ "ISBN:0198506732" ]
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        "synonyms" : [ {
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        "definition" : {
          "val" : "The chemical reactions and pathways involving bile acids, a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine.",
          "xrefs" : [ "GOC:go_curators" ]
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        "synonyms" : [ {
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      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.",
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        } ]
      }
    }, {
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      "lbl" : "C21-steroid hormone catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones.",
          "xrefs" : [ "GOC:ai" ]
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        "synonyms" : [ {
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          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "C21-steroid hormone degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008211",
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      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glucocorticoid metabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glucocorticosteroid metabolic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "glucocorticosteroid metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008212",
      "lbl" : "mineralocorticoid metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mineralocorticoid metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008217",
      "lbl" : "regulation of blood pressure",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_cardio", "ISBN:0721643949" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "blood pressure regulation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "blood pressure homeostasis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "control of blood pressure"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Blood_pressure#Regulation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008219",
      "lbl" : "cell death",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538).",
          "xrefs" : [ "GOC:mah", "GOC:mtg_apoptosis", "PMID:25236395" ]
        },
        "comments" : [ "This term should not be used for direct annotation, it is currently kept in GO as a placeholder for describing cell death phenotypes in uPHENO. When information is provided on a programmed cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Unintentional cell death, i.e. cell death caused by injury, ageing, or cell phenotypes observed as a result of a pathological mutation in an essential gene should NOT be annotated using GO terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "accidental cell death"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "necrosis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/24680"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008227",
      "lbl" : "G protein-coupled amine receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.",
          "xrefs" : [ "GOC:bf", "GOC:dph" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "G-protein coupled amine receptor activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine receptor activity, G-protein coupled",
          "xrefs" : [ "GOC:bf" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "biogenic amine receptor"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008271",
      "lbl" : "secondary active sulfate transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters.",
          "xrefs" : [ "GOC:mtg_transport" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "secondary active sulphate transmembrane transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sulphate porter activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "sulfate porter activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008277",
      "lbl" : "regulation of G protein-coupled receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of G protein coupled receptor protein signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of G protein coupled receptor protein signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of G-protein coupled receptor protein signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of G-protein coupled receptor protein signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of G-protein-coupled receptor protein signalling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of GPCR protein signaling pathway"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of GPCR protein signalling pathway"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008283",
      "lbl" : "cell population proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of cells, resulting in the expansion of a cell population.",
          "xrefs" : [ "GOC:mah", "GOC:mb" ]
        },
        "comments" : [ "This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "cell proliferation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008284",
      "lbl" : "positive regulation of cell population proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the rate or extent of cell proliferation.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "up regulation of cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "up-regulation of cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "activation of cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "stimulation of cell proliferation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of cell proliferation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008285",
      "lbl" : "negative regulation of cell population proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents or reduces the rate or extent of cell proliferation.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of cell proliferation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of cell proliferation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of cell proliferation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of cell proliferation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008286",
      "lbl" : "insulin receptor signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.",
          "xrefs" : [ "GOC:ceb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "insulin receptor signalling pathway"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "daf-2 receptor signaling pathway"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-74752"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008289",
      "lbl" : "lipid binding",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Binding to a lipid.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote", "http://purl.obolibrary.org/obo/go#goslim_prokaryote_ribbon", "http://purl.obolibrary.org/obo/go#goslim_yeast" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008291",
      "lbl" : "acetylcholine metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues.",
          "xrefs" : [ "GOC:jl", "GOC:nln", "ISBN:0192800752" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008292",
      "lbl" : "acetylcholine biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline.",
          "xrefs" : [ "GOC:jl", "ISBN:0192800752" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "acetylcholine synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008299",
      "lbl" : "isoprenoid biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid synthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid anabolism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid biosynthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid biosynthetic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid formation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid synthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyterpene biosynthesis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyterpene biosynthetic process"
        } ],
        "xrefs" : [ {
          "val" : "MetaCyc:POLYISOPRENSYN-PWY"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009241"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008300",
      "lbl" : "isoprenoid catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "isoprenoid degradation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid breakdown"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid catabolic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid catabolism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyisoprenoid degradation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyterpene catabolic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "polyterpene catabolism"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "https://github.com/geneontology/go-ontology/issues/28908"
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          "val" : "GO:0016097"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008320",
      "lbl" : "protein transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a protein from one side of a membrane to the other.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "protein channel activity"
        } ],
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          "val" : "Reactome:R-HSA-1268022"
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          "val" : "Reactome:R-HSA-1299475"
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          "val" : "Reactome:R-HSA-184269"
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          "val" : "Reactome:R-HSA-5205661"
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          "val" : "Reactome:R-HSA-5210943"
        }, {
          "val" : "Reactome:R-HSA-5210947"
        }, {
          "val" : "Reactome:R-HSA-5228406"
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        }, {
          "val" : "Reactome:R-HSA-5244404"
        }, {
          "val" : "Reactome:R-HSA-5244428"
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          "val" : "Reactome:R-HSA-5244506"
        }, {
          "val" : "Reactome:R-HSA-5246514"
        }, {
          "val" : "Reactome:R-HSA-5250616"
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          "val" : "Reactome:R-HSA-5250884"
        }, {
          "val" : "Reactome:R-HSA-5250972"
        }, {
          "val" : "Reactome:R-HSA-5336420"
        }, {
          "val" : "Reactome:R-HSA-9636375"
        }, {
          "val" : "Reactome:R-HSA-9698930"
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          "val" : "Reactome:R-HSA-9698933"
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          "val" : "Reactome:R-HSA-9760705"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0015266"
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          "val" : "GO:0015463"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008324",
      "lbl" : "monoatomic cation transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of cation from one side of a membrane to the other.",
          "xrefs" : [ "GOC:dgf", "GOC:mtg_transport", "ISBN:0815340729" ]
        },
        "synonyms" : [ {
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          "val" : "cation transmembrane transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "transmembrane cation transporter activity"
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        "basicPropertyValues" : [ {
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          "val" : "molecular_function"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "protein"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008347",
      "lbl" : "glial cell migration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.",
          "xrefs" : [ "GOC:jl", "GOC:mtg_sensu" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glia cell migration"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0043359"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008348",
      "lbl" : "negative regulation of antimicrobial humoral response",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "attenuation of antimicrobial humoral response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of antimicrobial humoral response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of antimicrobial humoral response"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of antimicrobial humoral response"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of antimicrobial humoral response"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0042154"
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          "val" : "GO:0042155"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008354",
      "lbl" : "germ cell migration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form.",
          "xrefs" : [ "GOC:bf", "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "germ-cell migration"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "pole cell migration"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "primordial germ cell migration"
        } ],
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "lipid synthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lipogenesis",
          "xrefs" : [ "GOC:sl" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008641",
      "lbl" : "ubiquitin-like modifier activating enzyme activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond.",
          "xrefs" : [ "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "small protein activating enzyme activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/14208"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008642"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008643",
      "lbl" : "carbohydrate transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "sugar transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0006861"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008644"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008645",
      "lbl" : "hexose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which hexose is transported across a membrane. Hexoses are aldoses with a chain of six carbon atoms in the molecule.",
          "xrefs" : [ "GOC:vw" ]
        },
        "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "high-affinity hexose transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "low-affinity hexose transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "hexose membrane transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "hexose transport"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-189200"
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        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "bf"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2010-04-08T10:27:23Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008646"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008647"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0035428"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008652",
      "lbl" : "amino acid biosynthetic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amino acid anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amino acid biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amino acid formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amino acid synthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular amino acid biosynthetic process"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Amino_acid_synthesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/17904"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/27304"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008654",
      "lbl" : "phospholipid biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid synthesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/20092"
        }, {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28527"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0008757",
      "lbl" : "S-adenosylmethionine-dependent methyltransferase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "S-adenosyl methionine-dependent methyltransferase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "SAM-dependent methyltransferase activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "molecular_function"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009008",
      "lbl" : "DNA-methyltransferase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the transfer of a methyl group to a DNA molecule.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732", "PMID:7862522" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "DNA methylase"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA methyltransferase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "DNA transmethylase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "deoxyribonucleate methylase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "deoxyribonucleate methyltransferase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "deoxyribonucleic acid methylase activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "deoxyribonucleic acid methyltransferase activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Type II DNA methylase",
          "xrefs" : [ "EC:2.1.1.37" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "deoxyribonucleic acid modification methylase activity"
        } ],
        "xrefs" : [ {
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009048",
      "lbl" : "dosage compensation by inactivation of X chromosome",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by heterochromatin formation leading to a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex.",
          "xrefs" : [ "GOC:jl", "GOC:mr", "GOC:pr", "PMID:11498577", "PMID:20622855", "Wikipedia:XY_sex-determination_system" ]
        },
        "synonyms" : [ {
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          "val" : "chromosome inactivation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "X chromosome inactivation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "Barr body formation"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:X-inactivation"
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        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/25955"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009055",
      "lbl" : "electron transfer activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways.",
          "xrefs" : [ "Wikipedia:Electron_transfer" ]
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        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
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        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "electron donor activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "electron carrier"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "electron transporter activity"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-169260"
        }, {
          "val" : "Reactome:R-HSA-2564826"
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009056",
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        "definition" : {
          "val" : "A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.",
          "xrefs" : [ "ISBN:0198547684" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "breakdown of molecule"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "breakdown of substance"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular degradation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "degradation"
        } ],
        "xrefs" : [ {
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        "basicPropertyValues" : [ {
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    }, {
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          "xrefs" : [ "GOC:mtg_chebi_dec09" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "macromolecule breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "macromolecule catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "macromolecule degradation"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organismal macromolecule catabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cellular macromolecule catabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cellular macromolecule catabolism"
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          "pred" : "hasRelatedSynonym",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "anabolism"
        }, {
          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "synthesis"
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          "val" : "multicellular organismal biosynthetic process"
        }, {
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          "val" : "single-organism biosynthetic process"
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    }, {
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.",
          "xrefs" : [ "GOC:mah" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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        "basicPropertyValues" : [ {
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    }, {
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      "id" : "http://purl.obolibrary.org/obo/GO_0009062",
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        },
        "synonyms" : [ {
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          "val" : "ribonucleotide anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide synthesis"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009261",
      "lbl" : "ribonucleotide catabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide breakdown"
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          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "ribonucleotide degradation"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009295",
      "lbl" : "nucleoid",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined.",
          "xrefs" : [ "GOC:bm", "GOC:ma", "ISBN:3540076689" ]
        },
        "xrefs" : [ {
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009306",
      "lbl" : "protein secretion",
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        "definition" : {
          "val" : "The controlled release of proteins from a cell.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
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          "val" : "glycoprotein secretion"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "protein secretion during cell fate commitment"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "protein secretion resulting in cell fate commitment"
        } ],
        "basicPropertyValues" : [ {
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009308",
      "lbl" : "amine metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amine metabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular amine metabolic process"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-07-15T11:55:44Z"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044106"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009309",
      "lbl" : "amine biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.",
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        "synonyms" : [ {
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          "val" : "amine anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009310",
      "lbl" : "amine catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom.",
          "xrefs" : [ "GOC:jl", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amine breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amine degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009314",
      "lbl" : "response to radiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation.",
          "xrefs" : [ "GOC:jl", "Wikipedia:Electromagnetic_radiation" ]
        },
        "comments" : [ "Note that 'radiation' refers to electromagnetic radiation of any wavelength." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to electromagnetic radiation stimulus"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "response to radiation stimulus"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009395",
      "lbl" : "phospholipid catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "phospholipid degradation"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/28908"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009410",
      "lbl" : "response to xenobiotic stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.",
          "xrefs" : [ "GOC:jl", "GOC:krc" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "drug resistance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "drug susceptibility/resistance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "response to drug"
        } ],
        "basicPropertyValues" : [ {
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0017035"
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          "val" : "GO:0017104"
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          "val" : "GO:0042493"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009415",
      "lbl" : "response to water",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water.",
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          "val" : "response to water stimulus",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009416",
      "lbl" : "response to light stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0582227089" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009448",
      "lbl" : "gamma-aminobutyric acid metabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.",
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        },
        "comments" : [ "See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'." ],
        "synonyms" : [ {
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
          "val" : "GABA metabolic process"
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    }, {
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms.",
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        },
        "comments" : [ "See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'." ],
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          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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        }, {
          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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          "pred" : "hasExactSynonym",
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      "id" : "http://purl.obolibrary.org/obo/GO_0009566",
      "lbl" : "fertilization",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy).",
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          "val" : "The series of events in which an external stimulus is received by a cell and converted into a molecular signal.",
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          "val" : "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm.",
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        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism.",
          "xrefs" : [ "GOC:hb" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "physiological response to wounding"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0002245"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009612",
      "lbl" : "response to mechanical stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus.",
          "xrefs" : [ "GOC:hb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "mechanical stimulus response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "chemi-mechanical coupling"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009615",
      "lbl" : "response to virus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.",
          "xrefs" : [ "GOC:hb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to viruses"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9824446"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009617",
      "lbl" : "response to bacterium",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.",
          "xrefs" : [ "GOC:hb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to bacteria"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-9824439"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009618"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009680"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009620",
      "lbl" : "response to fungus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus.",
          "xrefs" : [ "GOC:hb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to fungi"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009621"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009628",
      "lbl" : "response to abiotic stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus.",
          "xrefs" : [ "GOC:hb" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "response to abiotic stress"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/16572"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009629",
      "lbl" : "response to gravity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus.",
          "xrefs" : [ "GOC:hb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to gravitational stimulus"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009636",
      "lbl" : "response to toxic substance",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.",
          "xrefs" : [ "GOC:lr" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "detoxification response"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "toxin resistance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "toxin susceptibility/resistance"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009651",
      "lbl" : "response to salt stress",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to ionic osmotic stress"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "salinity response"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009653",
      "lbl" : "anatomical structure morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "embryogenesis and morphogenesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "anatomical structure organization"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "morphogenesis"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Morphogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009712",
      "lbl" : "catechol-containing compound metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent.",
          "xrefs" : [ "GOC:sm", "ISBN:0198547684" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol metabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009713",
      "lbl" : "catechol-containing compound biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol anabolism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol biosynthesis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol biosynthetic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol formation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "catechol synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009719",
      "lbl" : "response to endogenous stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism.",
          "xrefs" : [ "GOC:sm" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009725",
      "lbl" : "response to hormone",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to hormone stimulus",
          "xrefs" : [ "GOC:dos" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "growth regulator"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009743",
      "lbl" : "response to carbohydrate",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to carbohydrate stimulus",
          "xrefs" : [ "GOC:dos" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009746",
      "lbl" : "response to hexose",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to hexose stimulus",
          "xrefs" : [ "GOC:dos" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009749",
      "lbl" : "response to glucose",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.",
          "xrefs" : [ "GOC:jl" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to glucose stimulus",
          "xrefs" : [ "GOC:dos" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009755",
      "lbl" : "hormone-mediated signaling pathway",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of molecular signals mediated by the detection of a hormone.",
          "xrefs" : [ "GOC:sm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "hormone mediated signalling"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009786",
      "lbl" : "regulation of asymmetric cell division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of asymmetric cell division.",
          "xrefs" : [ "GOC:lr" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009790",
      "lbl" : "embryo development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant.",
          "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "embryogenesis and morphogenesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "embryogenesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "embryonal development"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-5619507"
        }, {
          "val" : "Wikipedia:Embryogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009795"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009791",
      "lbl" : "post-embryonic development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_plant" ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009792",
      "lbl" : "embryo development ending in birth or egg hatching",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.",
          "xrefs" : [ "GOC:go_curators", "GOC:isa_complete", "GOC:mtg_sensu" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "embryogenesis"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009798",
      "lbl" : "axis specification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The establishment, maintenance and elaboration of a pattern along a line or around a point.",
          "xrefs" : [ "GOC:dph", "GOC:go_curators", "GOC:isa_complete" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "axis determination"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009799",
      "lbl" : "specification of symmetry",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "determination of symmetry",
          "xrefs" : [ "GOC:dph" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009820",
      "lbl" : "alkaloid metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).",
          "xrefs" : [ "GOC:lr", "ISBN:0122146743" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_chembl" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009821",
      "lbl" : "alkaloid biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases).",
          "xrefs" : [ "GOC:lr", "ISBN:0122146743" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009822",
      "lbl" : "alkaloid catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases).",
          "xrefs" : [ "GOC:lr", "ISBN:0122146743" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "alkaloid degradation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009855",
      "lbl" : "determination of bilateral symmetry",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "determination of bilateral asymmetry",
          "xrefs" : [ "GOC:dph" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009880",
      "lbl" : "embryonic pattern specification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process that results in the patterns of cell differentiation that will arise in an embryo.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0521436125" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "embryonic pattern biosynthesis"
        }, {
          "pred" : "hasBroadSynonym",
          "val" : "embryonic pattern formation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "ventral/lateral system"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009887",
      "lbl" : "animal organ morphogenesis",
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          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction.",
          "xrefs" : [ "GOC:sm" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of signal transduction"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of signal transduction"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of signal transduction"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of signal transduction"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of signaling pathway"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of signalling pathway",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-8849472"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0035467"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009977",
      "lbl" : "proton motive force dependent protein transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane.",
          "xrefs" : [ "PMID:11526245", "PMID:25494301" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "arginine targeting transmembrane transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "delta-pH-dependent protein transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "pH-dependent protein transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "twin-arginine targeting transmembrane transporter activity"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015557"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009986",
      "lbl" : "cell surface",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The external part of the cell wall and/or plasma membrane.",
          "xrefs" : [ "GOC:jl", "GOC:mtg_sensu", "GOC:sm" ]
        },
        "comments" : [ "Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall." ],
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell associated"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cell bound"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0009928"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0009929"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009987",
      "lbl" : "cellular process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.",
          "xrefs" : [ "GOC:go_curators", "GOC:isa_complete" ]
        },
        "comments" : [ "This term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell physiology"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular physiological process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "cell growth and/or maintenance"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single-organism cellular process"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "jl"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2012-12-11T16:56:55Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0008151"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044763"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0050875"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009988",
      "lbl" : "cell-cell recognition",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Cell recognition between cells. May involve the formation of specialized cell junctions.",
          "xrefs" : [ "ISBN:0824072820" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009992",
      "lbl" : "intracellular water homeostasis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A homeostatic process involved in the maintenance of a steady state level of water within a cell.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cellular water homeostasis"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cellular osmoregulation",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009994",
      "lbl" : "oocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete.",
          "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "oocyte cell differentiation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0009996",
      "lbl" : "negative regulation of cell fate specification",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that restricts, stops or prevents a cell from adopting a specific cell fate.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "down regulation of cell fate specification"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "down-regulation of cell fate specification"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of cell fate specification"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "suppression of cell fate"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of cell fate specification"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010001",
      "lbl" : "glial cell differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell.",
          "xrefs" : [ "GOC:go_curators", "GOC:mtg_sensu" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "glia cell differentiation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "neuroglia differentiation"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0007404"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0043360"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010002",
      "lbl" : "cardioblast differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cardiac precursor cell differentiation",
          "xrefs" : [ "GOC:mtg_heart" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cardioblast cell differentiation"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cardiomyocyte generation"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010021",
      "lbl" : "amylopectin biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages.",
          "xrefs" : [ "ISBN:0943088399" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "amylopectin anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amylopectin biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amylopectin formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "amylopectin synthesis"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010032",
      "lbl" : "meiotic chromosome condensation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Compaction of chromatin structure prior to meiosis in eukaryotic cells.",
          "xrefs" : [ "PMID:10072401" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chromosome condensation involved in meiotic cell cycle",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010034",
      "lbl" : "response to acetate",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus.",
          "xrefs" : [ "GOC:sm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010037",
      "lbl" : "response to carbon dioxide",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus.",
          "xrefs" : [ "GOC:sm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010038",
      "lbl" : "response to metal ion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.",
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        },
        "synonyms" : [ {
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          "val" : "response to metal"
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          "pred" : "hasNarrowSynonym",
          "val" : "response to heavy metal"
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          "pred" : "hasRelatedSynonym",
          "val" : "heavy metal sensitivity/resistance"
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        "xrefs" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010039",
      "lbl" : "response to iron ion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus.",
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        "synonyms" : [ {
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          "val" : "response to iron"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010070",
      "lbl" : "zygote asymmetric cell division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials.",
          "xrefs" : [ "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "zygote asymmetric cytokinesis"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010155",
      "lbl" : "regulation of proton transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:sm" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010160",
      "lbl" : "formation of animal organ boundary",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.",
          "xrefs" : [ "GOC:dph", "GOC:isa_complete", "PMID:9611175" ]
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        "synonyms" : [ {
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          "val" : "organ boundary specification"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010171",
      "lbl" : "body morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the anatomical structures of the soma are generated and organized.",
          "xrefs" : [ "GOC:ems", "ISBN:0140512888" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010232",
      "lbl" : "vascular transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane.",
          "xrefs" : [ "GOC:sm" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010248",
      "lbl" : "establishment or maintenance of transmembrane electrochemical gradient",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010256",
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      "type" : "CLASS",
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          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system.",
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          "val" : "endomembrane system organisation",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010324",
      "lbl" : "membrane invagination",
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        "definition" : {
          "val" : "The infolding of a membrane.",
          "xrefs" : [ "GOC:tb" ]
        },
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      "lbl" : "regulation of G2/M transition of mitotic cell cycle",
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        "definition" : {
          "val" : "Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.",
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      "lbl" : "regulation of cell fate commitment",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010454",
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      "lbl" : "positive regulation of cell fate commitment",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010456",
      "lbl" : "cell proliferation in dorsal spinal cord",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010463",
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      "type" : "CLASS",
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        "definition" : {
          "val" : "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets.",
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      "lbl" : "regulation of mesenchymal cell proliferation",
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      "lbl" : "regulation of signaling receptor activity",
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      "lbl" : "regulation of gastrulation",
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          "val" : "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010496",
      "lbl" : "intercellular transport",
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    }, {
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          "val" : "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.",
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          "val" : "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010666",
      "lbl" : "positive regulation of cardiac muscle cell apoptotic process",
      "type" : "CLASS",
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          "val" : "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_apoptosis", "GOC:tb" ]
        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010667",
      "lbl" : "negative regulation of cardiac muscle cell apoptotic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death.",
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        }, {
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          "val" : "inhibition of cardiac muscle cell apoptosis",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010668",
      "lbl" : "ectodermal cell differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate.",
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        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010694",
      "lbl" : "positive regulation of alkaline phosphatase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010700",
      "lbl" : "negative regulation of norepinephrine secretion",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      "lbl" : "positive regulation of norepinephrine secretion",
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        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine.",
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      "lbl" : "regulation of collagen catabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
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          "val" : "regulation of collagen breakdown",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of collagen catabolism",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of collagen degradation",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0010711",
      "lbl" : "negative regulation of collagen catabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
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          "val" : "down regulation of collagen catabolic process",
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          "val" : "down-regulation of collagen catabolic process",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "downregulation of collagen catabolic process",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of collagen breakdown",
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of collagen catabolism",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of collagen degradation",
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          "pred" : "hasNarrowSynonym",
          "val" : "inhibition of collagen catabolic process",
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      "id" : "http://purl.obolibrary.org/obo/GO_0010712",
      "lbl" : "regulation of collagen metabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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      "lbl" : "negative regulation of collagen metabolic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }
      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0010714",
      "lbl" : "positive regulation of collagen metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
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      "id" : "http://purl.obolibrary.org/obo/GO_0010715",
      "lbl" : "regulation of extracellular matrix disassembly",
      "type" : "CLASS",
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          "val" : "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.",
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        },
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          "val" : "regulation of extracellular matrix degradation",
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      "lbl" : "negative regulation of extracellular matrix disassembly",
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          "val" : "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.",
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        },
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      "id" : "http://purl.obolibrary.org/obo/GO_0010717",
      "lbl" : "regulation of epithelial to mesenchymal transition",
      "type" : "CLASS",
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          "val" : "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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      "lbl" : "positive regulation of epithelial to mesenchymal transition",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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          "val" : "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010720",
      "lbl" : "positive regulation of cell development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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      "lbl" : "negative regulation of cell development",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010725",
      "lbl" : "regulation of primitive erythrocyte differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis.",
          "xrefs" : [ "GOC:add", "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
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          "val" : "regulation of primitive RBC differentiation",
          "xrefs" : [ "CL:0000232" ]
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          "pred" : "hasExactSynonym",
          "val" : "regulation of primitive erythropoeisis",
          "xrefs" : [ "GOC:add", "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "regulation of primitive red blood cell differentiation",
          "xrefs" : [ "CL:0000232" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010758",
      "lbl" : "regulation of macrophage chemotaxis",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.",
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      "type" : "CLASS",
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          "val" : "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus.",
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      "type" : "CLASS",
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          "val" : "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules.",
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      "lbl" : "positive regulation of sodium ion transport",
      "type" : "CLASS",
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          "val" : "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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      "lbl" : "negative regulation of sodium ion transport",
      "type" : "CLASS",
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          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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      "type" : "CLASS",
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          "val" : "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history.",
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          "val" : "https://github.com/geneontology/go-ontology/issues/24299"
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          "val" : "https://github.com/geneontology/go-ontology/issues/24299"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010816",
      "lbl" : "calcitonin catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin.",
          "xrefs" : [ "GOC:BHF", "GOC:rl" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010817",
      "lbl" : "regulation of hormone levels",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010818",
      "lbl" : "T cell chemotaxis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "T-cell chemotaxis",
          "xrefs" : [ "CL:0000084" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010819",
      "lbl" : "regulation of T cell chemotaxis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010820",
      "lbl" : "positive regulation of T cell chemotaxis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010821",
      "lbl" : "regulation of mitochondrion organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of mitochondrion organisation",
          "xrefs" : [ "GOC:mah" ]
        } ],
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010827",
      "lbl" : "regulation of D-glucose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "regulation of glucose transmembrane transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "regulation of glucose transport"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010828",
      "lbl" : "positive regulation of D-glucose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of glucose transmembrane transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of glucose transport"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010829",
      "lbl" : "negative regulation of D-glucose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of glucose transmembrane transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "negative regulation of glucose transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010830",
      "lbl" : "regulation of myotube differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010831",
      "lbl" : "positive regulation of myotube differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010832",
      "lbl" : "negative regulation of myotube differentiation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010837",
      "lbl" : "regulation of keratinocyte proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010838",
      "lbl" : "positive regulation of keratinocyte proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010839",
      "lbl" : "negative regulation of keratinocyte proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010842",
      "lbl" : "retina layer formation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia.",
          "xrefs" : [ "GOC:ascb_2009", "GOC:dph", "GOC:tb", "PMID:1270266" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "retinal lamination",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "retinal layer formation",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010874",
      "lbl" : "regulation of cholesterol efflux",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010875",
      "lbl" : "positive regulation of cholesterol efflux",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010876",
      "lbl" : "lipid localization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which a lipid is transported to, or maintained in, a specific location.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lipid localisation",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010892",
      "lbl" : "positive regulation of mitochondrial translation in response to stress",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress.",
          "xrefs" : [ "GOC:dph", "GOC:jp", "GOC:tb", "PMID:8830768" ]
        },
        "basicPropertyValues" : [ {
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        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010893",
      "lbl" : "positive regulation of steroid biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.",
          "xrefs" : [ "GOC:tb" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010894",
      "lbl" : "negative regulation of steroid biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.",
          "xrefs" : [ "GOC:BHF", "GOC:tb" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010906",
      "lbl" : "regulation of glucose metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.",
          "xrefs" : [ "GOC:BHF", "GOC:tb" ]
        },
        "synonyms" : [ {
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          "val" : "regulation of glucose metabolism",
          "xrefs" : [ "GOC:tb" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010907",
      "lbl" : "positive regulation of glucose metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.",
          "xrefs" : [ "GOC:BHF", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of glucose metabolism",
          "xrefs" : [ "GOC:tb" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010921",
      "lbl" : "regulation of phosphatase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing phosphate.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
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      "lbl" : "positive regulation of phosphatase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
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      "lbl" : "negative regulation of phosphatase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_obsoletion_candidate" ],
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010927",
      "lbl" : "cellular component assembly involved in morphogenesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The cellular component assembly that is part of the initial shaping of the component during its developmental progression.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0010934",
      "lbl" : "macrophage cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:rl", "GOC:tb" ]
        },
        "comments" : [ "Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select one of the 'regulation' children terms." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate" ],
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      "lbl" : "regulation of macrophage cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:BHF", "GOC:rl" ]
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      "lbl" : "negative regulation of macrophage cytokine production",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.",
          "xrefs" : [ "GOC:BHF", "GOC:rl" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010937",
      "lbl" : "regulation of cytoplasmic microtubule depolymerization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010938",
      "lbl" : "cytoplasmic microtubule depolymerization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        }
      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0010948",
      "lbl" : "negative regulation of cell cycle process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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          "val" : "2009-04-27T09:53:22Z"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010949",
      "lbl" : "negative regulation of intestinal phytosterol absorption",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:tb" ]
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-04-27T11:02:06Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010954",
      "lbl" : "positive regulation of protein processing",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of protein maturation by peptide bond cleavage",
          "xrefs" : [ "GOC:bf" ]
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2009-04-27T12:09:13Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010955",
      "lbl" : "negative regulation of protein processing",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of protein maturation by peptide bond cleavage",
          "xrefs" : [ "GOC:bf" ]
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
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          "val" : "2009-04-27T12:10:19Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010958",
      "lbl" : "regulation of amino acid import across plasma membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of amino acid import into a cell.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "regulation of amino acid import"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-06T11:33:12Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010959",
      "lbl" : "regulation of metal ion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-06T11:40:55Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010960",
      "lbl" : "magnesium ion homeostasis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-06T11:47:17Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010962",
      "lbl" : "regulation of glucan biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-11T12:17:53Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010965",
      "lbl" : "regulation of mitotic sister chromatid separation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-20T11:39:07Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010966",
      "lbl" : "regulation of phosphate transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-20T11:42:50Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010968",
      "lbl" : "regulation of microtubule nucleation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "basicPropertyValues" : [ {
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        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-20T11:51:21Z"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010970",
      "lbl" : "transport along microtubule",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity.",
          "xrefs" : [ "GOC:dph", "GOC:mah", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "microtubule-based transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "establishment of localization by movement along microtubule",
          "xrefs" : [ "GOC:dph" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "movement along microtubule"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "tb"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2009-05-27T10:56:08Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010971",
      "lbl" : "positive regulation of G2/M transition of mitotic cell cycle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_cell_cycle", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of mitotic entry",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "2009-06-01T10:16:34Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0031662"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010972",
      "lbl" : "negative regulation of G2/M transition of mitotic cell cycle",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.",
          "xrefs" : [ "GOC:mtg_cell_cycle" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of mitotic entry",
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010973",
      "lbl" : "positive regulation of division septum assembly",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.",
          "xrefs" : [ "GOC:mtg_cell_cycle", "PMID:19959363", "PMID:21246752", "PMID:22786806" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of division septum formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "positive regulation of division septum formation involved in cell cycle cytokinesis",
          "xrefs" : [ "GOC:TermGenie" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "upregulation of mitotic division septum assembly",
          "xrefs" : [ "GOC:TermGenie" ]
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        "basicPropertyValues" : [ {
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          "val" : "2009-06-01T10:27:15Z"
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          "val" : "GO:1901912"
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      "id" : "http://purl.obolibrary.org/obo/GO_0010974",
      "lbl" : "negative regulation of division septum assembly",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.",
          "xrefs" : [ "GOC:mtg_cell_cycle", "PMID:19959363", "PMID:21246752", "PMID:22786806" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "negative regulation of division septum formation"
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          "val" : "inhibition of division septum assembly involved in cell cycle cytokinesis",
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          "val" : "GO:1901139"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010975",
      "lbl" : "regulation of neuron projection development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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        "synonyms" : [ {
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          "val" : "regulation of neurite biosynthesis",
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          "pred" : "hasNarrowSynonym",
          "val" : "regulation of neurite development",
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        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of neurite formation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "regulation of neurite growth",
          "xrefs" : [ "GOC:mah" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010976",
      "lbl" : "positive regulation of neuron projection development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of neurite biosynthesis",
          "xrefs" : [ "GOC:mah" ]
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          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of neurite development",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of neurite formation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "positive regulation of neurite growth",
          "xrefs" : [ "GOC:mah" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0010977",
      "lbl" : "negative regulation of neuron projection development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).",
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          "val" : "negative regulation of neurite biosynthesis",
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          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of neurite development",
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        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of neurite formation",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "negative regulation of neurite growth",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "growth cone collapse",
          "xrefs" : [ "GOC:pr" ]
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          "val" : "biological_process"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0010996",
      "lbl" : "response to auditory stimulus",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus.",
          "xrefs" : [ "GOC:BHF", "GOC:dph", "GOC:sl", "GOC:tb" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "response to sound",
          "xrefs" : [ "GOC:dph", "GOC:sl", "GOC:tb" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "response to sound stimulus",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
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          "val" : "2009-06-10T11:09:38Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0012501",
      "lbl" : "programmed cell death",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell.",
          "xrefs" : [ "GOC:lr", "GOC:mtg_apoptosis" ]
        },
        "comments" : [ "Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children." ],
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_euk_cellular_processes_ribbon", "http://purl.obolibrary.org/obo/go#goslim_generic", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon", "http://purl.obolibrary.org/obo/go#goslim_prokaryote" ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "regulated cell death"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "caspase-independent cell death"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "non-apoptotic programmed cell death"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "nonapoptotic programmed cell death"
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      "id" : "http://purl.obolibrary.org/obo/GO_0014831",
      "lbl" : "gastro-intestinal system smooth muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract).",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014832",
      "lbl" : "urinary bladder smooth muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract.",
          "xrefs" : [ "GOC:mr", "GOC:mtg_muscle", "PMID:11768524", "PMID:18276178", "PMID:538956" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014835",
      "lbl" : "myoblast differentiation involved in skeletal muscle regeneration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.",
          "xrefs" : [ "CL:0000056", "GOC:ef", "GOC:mtg_muscle", "PMID:16607119" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014839",
      "lbl" : "myoblast migration involved in skeletal muscle regeneration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.",
          "xrefs" : [ "CL:0000056", "GOC:ef", "GOC:mtg_muscle", "PMID:16607119" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014841",
      "lbl" : "skeletal muscle satellite cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle", "PMID:16607119" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014842",
      "lbl" : "regulation of skeletal muscle satellite cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle", "PMID:16607119" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014848",
      "lbl" : "urinary tract smooth muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014849",
      "lbl" : "ureter smooth muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder.",
          "xrefs" : [ "GOC:mtg_muscle", "MA:0000378" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014852",
      "lbl" : "regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ]
        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014853",
      "lbl" : "regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.",
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          "val" : "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014855",
      "lbl" : "striated muscle cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle.",
          "xrefs" : [ "CL:0000737", "GOC:ef", "GOC:mtg_muscle" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014856",
      "lbl" : "skeletal muscle cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014857",
      "lbl" : "regulation of skeletal muscle cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation.",
          "xrefs" : [ "CL:0000188", "GOC:ef", "GOC:mtg_muscle" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014858",
      "lbl" : "positive regulation of skeletal muscle cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014859",
      "lbl" : "negative regulation of skeletal muscle cell proliferation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014860",
      "lbl" : "neurotransmitter secretion involved in regulation of skeletal muscle contraction",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin.",
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          "val" : "neurotransmitter secretion involved in control of skeletal muscle contraction",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014861",
      "lbl" : "regulation of skeletal muscle contraction via regulation of action potential",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes.",
          "xrefs" : [ "GOC:BHF", "GOC:mtg_cardiac_conduct_nov11", "GOC:mtg_muscle" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014866",
      "lbl" : "skeletal myofibril assembly",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014872",
      "lbl" : "myoblast division",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.",
          "xrefs" : [ "CL:0000056", "GOC:ef", "GOC:mtg_muscle" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0014874",
      "lbl" : "response to stimulus involved in regulation of muscle adaptation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ]
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          "val" : "response to stimulus involved in regulation of muscle plasticity"
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      "id" : "http://purl.obolibrary.org/obo/GO_0014878",
      "lbl" : "response to electrical stimulus involved in regulation of muscle adaptation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation.",
          "xrefs" : [ "GOC:ef", "GOC:mtg_muscle" ]
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          "val" : "response to electrical stimulus involved in regulation of muscle plasticity"
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      "id" : "http://purl.obolibrary.org/obo/GO_0014879",
      "lbl" : "detection of electrical stimulus involved in regulation of muscle adaptation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation.",
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0014887",
      "lbl" : "cardiac muscle adaptation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014888",
      "lbl" : "striated muscle adaptation",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014895",
      "lbl" : "smooth muscle hypertrophy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014896",
      "lbl" : "muscle hypertrophy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy.",
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      "lbl" : "striated muscle hypertrophy",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014902",
      "lbl" : "myotube differentiation",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
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      "lbl" : "myotube cell development",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
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      "lbl" : "myoblast fusion involved in skeletal muscle regeneration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.",
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      "lbl" : "myotube cell development involved in skeletal muscle regeneration",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
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      "lbl" : "myotube differentiation involved in skeletal muscle regeneration",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0014909",
      "lbl" : "smooth muscle cell migration",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism.",
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      "lbl" : "regulation of smooth muscle cell migration",
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          "val" : "Any process that modulates the frequency, rate or extent of smooth muscle cell migration.",
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      "lbl" : "positive regulation of smooth muscle cell migration",
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      "meta" : {
        "definition" : {
          "val" : "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration.",
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      "lbl" : "negative regulation of smooth muscle cell migration",
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          "val" : "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015030",
      "lbl" : "Cajal body",
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      "meta" : {
        "definition" : {
          "val" : "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015173",
      "lbl" : "aromatic amino acid transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring.",
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        },
        "synonyms" : [ {
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          "val" : "aromatic amino acid transporter activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "hydroxy/aromatic amino acid permease activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "valine/tyrosine/tryptophan permease activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015179",
      "lbl" : "L-amino acid transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids.",
          "xrefs" : [ "GOC:ai", "GOC:jsg", "GOC:mah", "GOC:mtg_transport", "ISBN:0815340729" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "L-amino acid transporter activity"
        } ],
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          "val" : "Reactome:R-HSA-212614"
        }, {
          "val" : "Reactome:R-HSA-352232"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015185",
      "lbl" : "gamma-aminobutyric acid transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA).",
          "xrefs" : [ "GOC:go_curators", "GOC:mtg_transport", "ISBN:0198506732", "ISBN:0815340729" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutanoate transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutyrate transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GABA transporter activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "betaine/GABA:sodium symporter activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015192",
      "lbl" : "L-phenylalanine transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid.",
          "xrefs" : [ "GOC:ai", "GOC:mtg_transport", "ISBN:0815340729" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "L-phenylalanine transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "L-phenylalanine permease activity"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015205",
      "lbl" : "nucleobase transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "GO:0015392"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015207",
      "lbl" : "adenine transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other.",
          "xrefs" : [ "GOC:go_curators" ]
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        "xrefs" : [ {
          "val" : "Reactome:R-HSA-163215"
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          "val" : "Reactome:R-HSA-5672027"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015211",
      "lbl" : "purine nucleoside transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015215",
      "lbl" : "nucleotide transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other.",
          "xrefs" : [ "ISBN:0198506732" ]
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      }
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      "id" : "http://purl.obolibrary.org/obo/GO_0015216",
      "lbl" : "purine nucleotide transmembrane transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other.",
          "xrefs" : [ "GOC:ai" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015217",
      "lbl" : "ADP transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015220",
      "lbl" : "choline transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "choline permease activity"
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          "val" : "amino acid/choline transmembrane transporter activity"
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          "val" : "Reactome:R-HSA-429594"
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          "val" : "Reactome:R-HSA-444433"
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          "val" : "Reactome:R-HSA-5658483"
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          "val" : "Reactome:R-HSA-6797956"
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          "val" : "GO:0005306"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015245",
      "lbl" : "fatty acid transmembrane transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.",
          "xrefs" : [ "ISBN:0198506732" ]
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        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "fatty-acyl group transporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "fatty acyl transporter activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "peroxisomal fatty acyl transporter"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "fatty acid transporter activity"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-5627891"
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          "val" : "Reactome:R-HSA-879585"
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          "val" : "Reactome:R-HSA-9032315"
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          "val" : "Reactome:R-HSA-9032323"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0015246"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015267",
      "lbl" : "channel activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the energy-independent facilitated diffusion of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules.",
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        "synonyms" : [ {
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          "val" : "pore activity"
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          "pred" : "hasExactSynonym",
          "val" : "channel/pore class transporter activity"
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          "pred" : "hasExactSynonym",
          "val" : "nonselective channel activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "alpha-type channel activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "channel-forming toxin activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "pore class transporter activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "substrate-specific channel activity"
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          "val" : "Reactome:R-HSA-3779381"
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          "val" : "Reactome:R-HSA-8953430"
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          "val" : "TC:1"
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          "val" : "GO:0015249"
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          "val" : "GO:0015268"
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          "val" : "GO:0022838"
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          "val" : "protein"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015269",
      "lbl" : "calcium-activated potassium channel activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transmembrane transfer of a potassium cation by a channel that opens when a calcium cation has been bound by the channel complex or one of its constituent parts.",
          "xrefs" : [ "GOC:dph", "GOC:mtg_transport" ]
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          "val" : "Reactome:R-HSA-9663752"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015276",
      "lbl" : "ligand-gated monoatomic ion channel activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts.",
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          "val" : "ligand-gated ion channel activity"
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          "val" : "ionotropic receptor activity",
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          "val" : "Reactome:R-HSA-451310"
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          "val" : "Reactome:R-HSA-622325"
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          "val" : "Reactome:R-HSA-622326"
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        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015291",
      "lbl" : "secondary active transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters.",
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        "synonyms" : [ {
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          "val" : "active transporter"
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          "pred" : "hasExactSynonym",
          "val" : "coupled carrier"
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          "pred" : "hasExactSynonym",
          "val" : "electrochemical potential-driven transporter activity"
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          "pred" : "hasExactSynonym",
          "val" : "porter activity"
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          "pred" : "hasExactSynonym",
          "val" : "porters"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "secondary carrier-type facilitators"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "energizer of outer membrane receptor-mediated transport activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "heavy metal ion porter activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "ion-gradient-driven energizer activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multidrug endosomal transmembrane transporter activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "nitrite/nitrate porter activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "galactose/glucose (methylgalactoside) porter activity"
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          "val" : "TC:2.A"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015293",
      "lbl" : "symporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.",
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          "val" : "cotransporter activity"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015294",
      "lbl" : "solute:monoatomic cation symporter activity",
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          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in).",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015296",
      "lbl" : "monoatomic anion:monoatomic cation symporter activity",
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        "definition" : {
          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in).",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015297",
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        "definition" : {
          "val" : "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out).",
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          "val" : "countertransporter activity"
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          "val" : "exchange transporter activity"
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          "val" : "solute:solute antiporter activity"
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          "val" : "ion antiporter activity"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015318",
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          "val" : "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015355",
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          "val" : "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0015377",
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          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in).",
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        "definition" : {
          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in).",
          "xrefs" : [ "TC:2.A.30.1.5" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "potassium ion symporter activity"
        } ],
        "xrefs" : [ {
          "val" : "RHEA:72427"
        }, {
          "val" : "Reactome:R-HSA-426155"
        }, {
          "val" : "Reactome:R-HSA-5623806"
        }, {
          "val" : "TC:2.A.30.1.5"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015385",
      "lbl" : "sodium:proton antiporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).",
          "xrefs" : [ "TC:2.A.35.1.1", "TC:2.A.36.-.-" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "sodium/hydrogen antiporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sodium:hydrogen antiporter activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sodium:hydrogen exchange activity"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "sodium:hydrogen exchanger"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "pH-dependent sodium:hydrogen antiporter activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "pH-dependent sodium:proton antiporter activity"
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          "val" : "RHEA:29251"
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          "val" : "Reactome:R-HSA-2889070"
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          "val" : "Reactome:R-HSA-425965"
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          "val" : "Reactome:R-HSA-425983"
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          "val" : "Reactome:R-HSA-425994"
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          "val" : "Reactome:R-HSA-426015"
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          "val" : "Reactome:R-HSA-5661039"
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          "val" : "GO:0015502"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015399",
      "lbl" : "primary active transmembrane transporter activity",
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          "val" : "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source. Primary energy sources known to be coupled to transport are chemical such as ATP hydrolysis, redox energy and photon energy.",
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        "synonyms" : [ {
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          "val" : "primary active transporter"
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          "val" : "EC:7.-.-.-"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015451",
      "lbl" : "decarboxylation-driven active transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.",
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        "synonyms" : [ {
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          "val" : "decarboxylation-driven transporter"
        } ],
        "xrefs" : [ {
          "val" : "EC:7.2.4.1"
        }, {
          "val" : "EC:7.2.4.2"
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          "val" : "EC:7.2.4.3"
        }, {
          "val" : "EC:7.2.4.4"
        }, {
          "val" : "TC:3.B"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015452",
      "lbl" : "methyl transfer-driven active transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.",
          "xrefs" : [ "GOC:mtg_transport", "ISBN:0815340729", "TC:3.C.-.-.-" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "Methyltransfer-driven transporters"
        } ],
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          "val" : "TC:3.C"
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        "basicPropertyValues" : [ {
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          "val" : "molecular_function"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015453",
      "lbl" : "oxidoreduction-driven active transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source.",
          "xrefs" : [ "GOC:mtg_transport", "ISBN:0815340729", "TC:3.D.-.-.-" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "oxidoreduction-driven transporter"
        } ],
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          "val" : "TC:3.D"
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          "val" : "molecular_function"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015464",
      "lbl" : "acetylcholine receptor activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Combining with an acetylcholine receptor ligand and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.",
          "xrefs" : [ "GOC:jl", "GOC:signaling" ]
        },
        "comments" : [ "For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'." ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015499",
      "lbl" : "formate transmembrane transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "formate uptake permease activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "formate uptake transmembrane transporter activity"
        } ],
        "xrefs" : [ {
          "val" : "MetaCyc:TRANS-RXN-1"
        } ],
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          "val" : "GO:0015659"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015552",
      "lbl" : "propionate transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015591",
      "lbl" : "D-ribose transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015605",
      "lbl" : "organophosphate ester transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds.",
          "xrefs" : [ "GOC:mcc" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015629",
      "lbl" : "actin cytoskeleton",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes.",
          "xrefs" : [ "GOC:jl", "ISBN:0395825172", "ISBN:0815316194" ]
        },
        "basicPropertyValues" : [ {
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          "val" : "cellular_component"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015630",
      "lbl" : "microtubule cytoskeleton",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins.",
          "xrefs" : [ "GOC:jl", "ISBN:0395825172" ]
        },
        "basicPropertyValues" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015631",
      "lbl" : "tubulin binding",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Binding to monomeric or multimeric forms of tubulin, including microtubules.",
          "xrefs" : [ "GOC:clt" ]
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015636",
      "lbl" : "short-chain fatty acid transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.",
          "xrefs" : [ "GOC:mah" ]
        },
        "comments" : [ "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283)." ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "short-chain fatty acid transporter activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "short-chain fatty acid uptake transporter activity"
        } ],
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          "val" : "GO:0015635"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015645",
      "lbl" : "fatty acid ligase activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP.",
          "xrefs" : [ "GOC:cjk", "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "fatty-acid ligase activity"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "fatty acid CoA ligase activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "fatty acyl-coenzyme A synthetase activity"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015651",
      "lbl" : "quaternary ammonium group transmembrane transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.",
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "quaternary amine transmembrane transporter activity"
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          "pred" : "hasExactSynonym",
          "val" : "quaternary ammonium compound transporter activity"
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          "val" : "GO:0015202"
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      "id" : "http://purl.obolibrary.org/obo/GO_0015662",
      "lbl" : "P-type ion transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate.",
          "xrefs" : [ "PMID:10322420", "PMID:10600683" ]
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        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism"
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          "pred" : "hasExactSynonym",
          "val" : "P-type ATPase activity"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity"
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          "pred" : "hasRelatedSynonym",
          "val" : "ion transmembrane transporter activity, phosphorylative mechanism"
        } ],
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      "id" : "http://purl.obolibrary.org/obo/GO_0015665",
      "lbl" : "alcohol transmembrane transporter activity",
      "type" : "CLASS",
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        "definition" : {
          "val" : "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
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          "val" : "Reactome:R-HSA-193832"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015669",
      "lbl" : "gas transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015670",
      "lbl" : "carbon dioxide transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015671",
      "lbl" : "oxygen transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "xrefs" : [ {
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015695",
      "lbl" : "organic cation transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage.",
          "xrefs" : [ "GOC:ai" ]
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      "id" : "http://purl.obolibrary.org/obo/GO_0015697",
      "lbl" : "quaternary ammonium group transport",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups.",
          "xrefs" : [ "GOC:ai", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "quaternary amine transport"
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          "pred" : "hasExactSynonym",
          "val" : "quaternary ammonium compound transport"
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          "val" : "GO:0015845"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015698",
      "lbl" : "inorganic anion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage.",
          "xrefs" : [ "GOC:krc" ]
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015701",
      "lbl" : "bicarbonate transport",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        },
        "synonyms" : [ {
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          "val" : "hydrogencarbonate transport"
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          "val" : "Reactome:R-HSA-1480926"
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          "val" : "Reactome:R-HSA-425381"
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    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015711",
      "lbl" : "organic anion transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage.",
          "xrefs" : [ "GOC:ai", "GOC:krc" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015718",
      "lbl" : "monocarboxylic acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015721",
      "lbl" : "bile acid and bile salt transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:dph", "GOC:krc", "PMID:12663868", "PMID:14699511" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "bile acid transport"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "bile salt transport"
        } ],
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-159418"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015723",
      "lbl" : "bilirubin transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015724",
      "lbl" : "formate transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015730",
      "lbl" : "propanoate transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:krc" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "propanoate transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "propionate transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/24587"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015748",
      "lbl" : "organophosphate ester transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds.",
          "xrefs" : [ "GOC:mcc" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015749",
      "lbl" : "monosaccharide transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides.",
          "xrefs" : [ "GOC:TermGenie", "GOC:vw", "GO_REF:0000069" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "monosaccharide transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#created_by",
          "val" : "vw"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2017-02-19T10:41:27Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:1905950"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015750",
      "lbl" : "pentose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "pentose transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015752",
      "lbl" : "D-ribose transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "D-ribose transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015774",
      "lbl" : "polysaccharide transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015800",
      "lbl" : "acidic amino acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015801",
      "lbl" : "aromatic amino acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015807",
      "lbl" : "L-amino acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai", "GOC:jsg", "GOC:mah" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015812",
      "lbl" : "gamma-aminobutyric acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ]
        },
        "comments" : [ "See also the biological process term 'neurotransmitter transport ; GO:0006836'." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutanoate transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "4-aminobutyrate transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "GABA transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015813",
      "lbl" : "L-glutamate transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of L-glutamate across a membrane by means of some agent such as a transporter or a pore.",
          "xrefs" : [ "PMID:21307582" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "L-glutamate transport"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "mitochondrial aspartate/glutamate transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0089711"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015823",
      "lbl" : "phenylalanine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "L-phenylalanine transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015828",
      "lbl" : "tyrosine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "L-tyrosine transport"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015833",
      "lbl" : "peptide transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015837",
      "lbl" : "amine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai", "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "amine/polyamine transport"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015844",
      "lbl" : "monoamine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:mah" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0015873"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015849",
      "lbl" : "organic acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir" ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015850",
      "lbl" : "organic hydroxy compound transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "organic alcohol transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015851",
      "lbl" : "nucleobase transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "nucleobase transmembrane transport",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015853",
      "lbl" : "adenine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:go_curators", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "adenine transmembrane transport",
          "xrefs" : [ "GOC:mah" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015858",
      "lbl" : "nucleoside transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015859",
      "lbl" : "intracellular nucleoside transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015860",
      "lbl" : "purine nucleoside transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar.",
          "xrefs" : [ "GOC:ai", "GOC:vw" ]
        },
        "comments" : [ "Note that this term is not intended for use in annotating lateral movement within membranes." ],
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "purine nucleoside transport",
          "xrefs" : [ "GOC:vw" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "purine nucleoside membrane transport"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0035427"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015865",
      "lbl" : "purine nucleotide transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015866",
      "lbl" : "ADP transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015867",
      "lbl" : "ATP transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015868",
      "lbl" : "purine ribonucleotide transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015870",
      "lbl" : "acetylcholine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.",
          "xrefs" : [ "GOC:ai" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015871",
      "lbl" : "choline transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015872",
      "lbl" : "dopamine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015874",
      "lbl" : "norepinephrine transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine.",
          "xrefs" : [ "GOC:ai", "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "levarterenol transport"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "noradrenaline transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015908",
      "lbl" : "fatty acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.",
          "xrefs" : [ "GOC:ai" ]
        }
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015912",
      "lbl" : "short-chain fatty acid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.",
          "xrefs" : [ "GOC:ai" ]
        },
        "comments" : [ "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283)." ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/26445"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015913",
      "lbl" : "short-chain fatty acid transmembrane transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of short-chain fatty acids into a cell or organelle. A short-chain fatty acid has an aliphatic tail containing fewer than 6 carbons.",
          "xrefs" : [ "GOC:ai" ]
        },
        "comments" : [ "While there is not universal consensus on the lengths of short-, medium-, long- and very-long-chain fatty acids, the GO uses the definitions in ChEBI (see CHEBI:26666, CHEBI:59554, CHEBI:15904 and CHEBI:27283)." ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "short-chain fatty acid uptake"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "short-chain fatty acid import"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
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          "pred" : "http://purl.obolibrary.org/obo/IAO_0000233",
          "val" : "https://github.com/geneontology/go-ontology/issues/26445"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015914",
      "lbl" : "phospholipid transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester.",
          "xrefs" : [ "GOC:ai" ]
        },
        "xrefs" : [ {
          "val" : "Reactome:R-HSA-1483196"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015918",
      "lbl" : "sterol transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.",
          "xrefs" : [ "GOC:ai" ]
        },
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015931",
      "lbl" : "nucleobase-containing compound transport",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "nucleobase, nucleoside, nucleotide and nucleic acid transport",
          "xrefs" : [ "GOC:dph", "GOC:tb" ]
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015932",
      "lbl" : "nucleobase-containing compound transmembrane transporter activity",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other.",
          "xrefs" : [ "GOC:ai" ]
        },
        "synonyms" : [ {
          "pred" : "hasRelatedSynonym",
          "val" : "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015942",
      "lbl" : "formate metabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.",
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        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "formate metabolism"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015943",
      "lbl" : "formate biosynthetic process",
      "type" : "CLASS",
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        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "formate anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formate biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formate formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formate synthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formic acid biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "formic acid biosynthetic process"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015980",
      "lbl" : "energy derivation by oxidation of organic compounds",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released.",
          "xrefs" : [ "GOC:mah" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "chemoorganotrophy"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0015986",
      "lbl" : "proton motive force-driven ATP synthesis",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of ATP driven by transport of protons across a membrane to generate an electrochemical gradient (proton-motive force).",
          "xrefs" : [ "GOC:vw" ]
        },
        "synonyms" : [ {
          "pred" : "hasBroadSynonym",
          "val" : "chemiosmosis",
          "xrefs" : [ "GOC:rs" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "ATP synthesis coupled proton transport"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016020",
      "lbl" : "membrane",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.",
          "xrefs" : [ "GOC:dos", "GOC:mah", "ISBN:0815316194" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_candida", "http://purl.obolibrary.org/obo/go#goslim_chembl", "http://purl.obolibrary.org/obo/go#goslim_flybase_ribbon", "http://purl.obolibrary.org/obo/go#goslim_metagenomics", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasNarrowSynonym",
          "val" : "integral component of membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "integral to membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "membrane region"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "region of membrane"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "whole membrane"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "transmembrane",
          "xrefs" : [ "GOC:mah" ]
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Biological_membrane"
        }, {
          "val" : "Wikipedia:Transmembrane_protein"
        } ],
        "basicPropertyValues" : [ {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#creation_date",
          "val" : "2014-03-06T11:37:54Z"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0016021"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0098589"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0098805"
        }, {
          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "cellular_component"
        } ]
      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016042",
      "lbl" : "lipid catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.",
          "xrefs" : [ "GOC:go_curators" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "lipid breakdown"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lipid catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lipid degradation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "lipolysis"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organism lipid catabolic process"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organismal lipid catabolic process"
        } ],
        "xrefs" : [ {
          "val" : "Wikipedia:Lipid_catabolism"
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        "basicPropertyValues" : [ {
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          "val" : "GO:0006724"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasAlternativeId",
          "val" : "GO:0044240"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016043",
      "lbl" : "cellular component organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component.",
          "xrefs" : [ "GOC:ai", "GOC:jl", "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_agr", "http://purl.obolibrary.org/obo/go#goslim_mouse", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant", "http://purl.obolibrary.org/obo/go#goslim_plant_ribbon" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cell organisation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular component organisation at cellular level",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular component organisation in other organism",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular component organization at cellular level"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "cellular component organization in other organism"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cell organization and biogenesis",
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        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0044235"
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          "val" : "GO:0071842"
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          "pred" : "http://www.geneontology.org/formats/oboInOwl#hasOBONamespace",
          "val" : "biological_process"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016049",
      "lbl" : "cell growth",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present.",
          "xrefs" : [ "GOC:ai" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#gocheck_do_not_annotate", "http://purl.obolibrary.org/obo/go#goslim_drosophila", "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_plant" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "cellular growth"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "growth of cell"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "cell expansion"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "metabolic process resulting in cell growth"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "metabolism resulting in cell growth"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "non-developmental cell growth",
          "xrefs" : [ "GOC:mah" ]
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "non-developmental growth of a unicellular organism",
          "xrefs" : [ "GOC:mah" ]
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        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016050",
      "lbl" : "vesicle organization",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.",
          "xrefs" : [ "GOC:mah" ]
        },
        "subsets" : [ "http://purl.obolibrary.org/obo/go#goslim_pir", "http://purl.obolibrary.org/obo/go#goslim_yeast" ],
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "vesicle organisation"
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          "pred" : "hasRelatedSynonym",
          "val" : "vesicle organization and biogenesis",
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        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016051",
      "lbl" : "carbohydrate biosynthetic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.",
          "xrefs" : [ "ISBN:0198506732" ]
        },
        "synonyms" : [ {
          "pred" : "hasExactSynonym",
          "val" : "anabolic carbohydrate metabolic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "anabolic carbohydrate metabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate anabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate biosynthesis"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate formation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate synthesis"
        } ],
        "basicPropertyValues" : [ {
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          "val" : "GO:0006093"
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      }
    }, {
      "id" : "http://purl.obolibrary.org/obo/GO_0016052",
      "lbl" : "carbohydrate catabolic process",
      "type" : "CLASS",
      "meta" : {
        "definition" : {
          "val" : "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.",
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        },
        "synonyms" : [ {
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        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate catabolism"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "carbohydrate degradation"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "catabolic carbohydrate metabolic process"
        }, {
          "pred" : "hasExactSynonym",
          "val" : "catabolic carbohydrate metabolism"
        }, {
          "pred" : "hasNarrowSynonym",
          "val" : "multicellular organismal carbohydrate catabolic process"
        }, {
          "pred" : "hasRelatedSynonym",
          "val" : "single-organism carbohydrate catabolic process"
        } ],
        "basicPropertyValues" : [ {
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      }
    }, {
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        }, {
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          "val" : "organic acid biosynthesis"
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          "pred" : "hasExactSynonym",
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        }, {
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    }, {
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        "definition" : {
          "val" : "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon.",
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      "id" : "http://purl.obolibrary.org/obo/GO_0016064",
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        "definition" : {
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        },
        "synonyms" : [ {
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      "id" : "http://purl.obolibrary.org/obo/GO_0016068",
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      "type" : "CLASS",
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        "definition" : {
          "val" : "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines.",
          "xrefs" : [ "GOC:add", "ISBN:0781735149" ]
        },
        "comments" : [ "Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity." ],
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        } ],
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      "lbl" : "RNA metabolic process",
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        "definition" : {
          "val" : "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.",
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