MP:0000001	mammalian phenotype	the observable morphological, physiological, behavioral and other characteristics of mammalian organisms that are manifested through development and lifespan
MP:0000002	obsolete Morphology	OBSOLETE.
MP:0000003	abnormal adipose tissue morphology	any structural anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue
MP:0000005	increased brown adipose tissue amount	increased amount of the thermogenic form of adipose tissue that is composed of brown adipocytes
MP:0000008	increased white adipose tissue amount	increased quantity of fat-storing cells/tissue
MP:0000010	abnormal abdominal fat pad morphology	any structural anomaly of the encapsulated adipose tissue in the abdomen
MP:0000012	obsolete loss of subcutaneous adipose tissue	OBSOLETE. reduction in amount or absence of adipose tissue beneath the skin
MP:0000013	abnormal adipose tissue distribution	alterations in the normal placement of body fat
MP:0000015	abnormal ear pigmentation	anomaly in the coloration of the skin of the outer ear due to changes in the amount, shape, or distribution of cells producing pigment
MP:0000017	big ears	outer ears of a greater than normal size
MP:0000018	small ears	outer ears of a smaller than normal size
MP:0000019	thick ears	increased width of the epidermal and cartilaginous tissue that makes up the ear
MP:0000020	scaly ears	loss of the outer layer of the epidermis of the ears in thick, dry scale-like patches
MP:0000021	prominent ears	protuberant outer ears
MP:0000022	abnormal ear shape	any anomaly in the characteristic surface outline or contour of the external ear
MP:0000023	abnormal ear position	anomaly in the space between or the placement of the outer ears
MP:0000024	lowered ear position	outer ears are situated below the normal location often giving the perception of protruding from the head
MP:0000025	otic hypertelorism	greater than normal space between the outer ears
MP:0000026	abnormal inner ear morphology	any structural anomaly of any components of the labyrinth, including the semicircular canals, vestibule and cochlea
MP:0000027	obsolete horizontal canal defects	OBSOLETE.
MP:0000028	abnormal pars superior vestibularis morphology	any structural anomaly in the part of the vestibular ganglion that receives fibers from the maculae of the utricle and the sacculae and the ampullae of the anterior and lateral semicircular ducts
MP:0000029	abnormal malleus morphology	any structural anomaly of the largest of the three auditory ossicles, which resembles a club or hammer
MP:0000030	abnormal tympanic ring morphology	any structural anomaly of the bony ring at the ear canal to which the tympanic membrane is attached
MP:0000031	abnormal cochlea morphology	any structural anomaly of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound
MP:0000032	cochlear degeneration	a retrogressive impairment of function or destruction of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound
MP:0000033	absent scala media	missing spiral tube within the cochlea that contains the organ of Corti, the neuroepithelial receptor organ for hearing
MP:0000034	abnormal inner ear vestibule morphology	any structural anomaly of the cavity between the semicircular canals and the cochlea of the inner ear
MP:0000035	abnormal membranous labyrinth morphology	any structural anomaly of the complex arrangement of communicating canaliculi and sacs suspended within the cavity of the bony labyrinth of the inner ear
MP:0000036	absent semicircular canals	missing organ of balance; consists of three bony tubes within which the semicircular ducts are located
MP:0000037	abnormal lateral semicircular canal morphology	any structural anomaly of the lateral long bony tube of the labyrinth that is involved in the sense of balance
MP:0000038	obsolete thin semicircular canals	OBSOLETE. decreased diameter of the three long bony tubes of the labyrinth that are involved in the sense of balance
MP:0000039	abnormal otic capsule morphology	any structural anomaly of the cartilage or bony capsule surrounding the inner ear mechanism
MP:0000040	absent middle ear ossicles	missing small bones of the tympanic cavity
MP:0000041	absent endolymphatic duct	missing small membranous canal of the inner ear; connecting membranous labyrinth with the endolymphatic sac
MP:0000042	abnormal organ of Corti morphology	any structural anomaly associated with the highly specialized epithelium in the floor of the ductus cochlearis; also referred to a spiral organ (organum spirale), or acoustic papilla
MP:0000043	organ of Corti degeneration	a retrogressive impairment of function or destruction of all or part the highly specialized epithelium in the floor of the ductus cochlearis
MP:0000044	absent organ of Corti	absence of the highly specialized epithelium in the floor of the ductus cochlearis
MP:0000045	abnormal hair cell morphology	any structural anomaly of the sensory epithelial cells of the inner ear
MP:0000046	abnormal sulcus ampullaris morphology	any structural anomaly of the transverse groove on the membranous amupulla of each semicircular duct, where the nerve enters the ampullary crest
MP:0000047	obsolete abnormal interdental cells	OBSOLETE.
MP:0000048	abnormal stria vascularis morphology	any structural anomaly in the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph; stria vascularis normally consists of marginal, intermediate, and basal cells: basal and marginal cell tight junctions preclude paracellular diffusion into and out of the intrastrial space while basal and intermediate cells secrete into this space potassium ions derived from fibrocytes through gap junctions
MP:0000049	abnormal middle ear morphology	any structural anomaly of any components of the tympanic cavity or its ossicles
MP:0000051	obsolete absent process brevus	OBSOLETE.
MP:0000052	early ear unfolding	early onset of the opening and spreading out of the outer ear
MP:0000053	excessive ear growth	overly robust development of the ear
MP:0000054	delayed ear emergence	late onset of the growth of the outer ear
MP:0000060	delayed bone ossification	late onset of the formation of bone
MP:0000061	fragile skeleton	easily damaged or broken bones
MP:0000062	increased bone mineral density	increase in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size
MP:0000063	decreased bone mineral density	reduction in the quatitative measurment value of mineral content of bone; BMD is used as an indicator of bone strength used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size
MP:0000064	failure of bone resorption	inability to degrade the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts
MP:0000065	abnormal bone marrow cavity morphology	any structural anomaly of the medullary cavities of the bones
MP:0000066	osteoporosis	reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility
MP:0000067	osteopetrosis	excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis
MP:0000069	kyphoscoliosis	kyphosis combined with scoliosis
MP:0000071	axial skeleton hypoplasia	decrease in the number of normal cells in normal arrangement in the axial skeleton, typically resulting in decreased size
MP:0000073	absent craniofacial bones	missing skeletal elements comprising the cranium and face
MP:0000074	abnormal neurocranium morphology	any structural anomaly of the bones of the skull enclosing the brain
MP:0000075	absent neurocranium	missing bones of the skull enclosing the brain
MP:0000077	abnormal interparietal bone morphology	any structural anomaly of the bone of the cranium that lies above and anterior to the occipital bone in some mammals
MP:0000078	abnormal supraoccipital bone morphology	any structural anomaly of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young
MP:0000079	abnormal basioccipital bone morphology	any structural anomaly of the basilar process of the occipital bone in the base of the cranium, frequently forming a direct part of the occipital in the adult, but usually distinct in the young
MP:0000080	abnormal exoccipital bone morphology	any structural anomaly of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young
MP:0000081	premature cranial suture closure	early closure of one or more of the joints (sutures) between the bones of the skull; can cause alterations in head shape, facial features, brain growth and, in rare cases, damage to the brain due to increased pressure inside the skull
MP:0000082	overlapping parietal bones	parietal bones of the skull partly coincide instead of articulating
MP:0000083	obsolete ectopic cranial bone growth	OBSOLETE. growth of extra bony structures in or near the cranium
MP:0000084	abnormal fontanelle morphology	any structural anomaly in the membranous interval at the margins of cranial bones in neonates
MP:0000085	large anterior fontanelle	enlarged diamond-shaped membranous interval at the junction of the coronal, sagittal and metopic sutures of the cranium
MP:0000087	absent mandible	missing the lower bony framework of the mouth where the inferior teeth are held
MP:0000088	short mandible	reduced length of the lower bony framework of the mouth where the inferior teeth are held
MP:0000090	absent premaxilla	missing anterior and interior portion of the maxilla
MP:0000091	short premaxilla	length reduction or truncation of the anterior and interior portion of the maxilla
MP:0000094	absent alveolar process	missing projecting ridge on the inferior surface of the body of the maxilla and mandible containing the tooth sockets
MP:0000097	short maxilla	reduced length of the upper jaw bone
MP:0000098	abnormal vomer bone morphology	any structural anomaly of the triangular flat bone of the nasal septum
MP:0000099	absent vomer bone	missing triangular flat bone of the nasal septum
MP:0000100	abnormal ethmoid bone morphology	any structural anomaly of the single midline facial bone that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits; it is cubical in shape, relatively lightweight because of its spongy construction, and contributes to the anterior cranial fossa
MP:0000101	absent ethmoid bone	missing the single midline facial bone that separates the nasal cavity from the brain, located at the roof of the nose between the two orbits; it is cubical in shape, relatively lightweight because of its spongy construction, and contributes to the anterior cranial fossa
MP:0000102	abnormal nasal bone morphology	any structural anomaly of either of two rectangular bone plates forming the bridge of the nose
MP:0000103	nasal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the nasal bone, typically resulting in decreased size
MP:0000104	abnormal sphenoid bone morphology	any structural anomaly of the irregularly shaped bone of the base of the skull
MP:0000105	impaired ossification of basisphenoid bone	anomaly in the formation of the bone at the base of the sphenoid bone; arises from an ossification center independent of the remainder of the sphenoid bone
MP:0000106	abnormal basisphenoid bone morphology	any structural anomaly of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone
MP:0000107	abnormal frontal bone morphology	any structural anomaly of the single bone forming the forehead and roof of the eye orbit
MP:0000108	midline facial cleft	incomplete merging or fusion of the tissues (e.g. the two globular processes) along the facial midline that normally unite to form the face
MP:0000109	abnormal parietal bone morphology	any structural anomaly of either of a pair of membranous bones of the roof of the skull located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium
MP:0000111	cleft palate	congenital fissure of the tissues normally uniting to form the palate
MP:0000114	cleft chin	incomplete fusion of the chin; usually a fissure
MP:0000116	abnormal tooth development	any anomaly in the formation of the teeth
MP:0000117	absent tooth placode	missing the local thickening that is normally formed within the primary dental lamina and grows into a solid epithelial tooth bud that invades the underlying mesenchyme; the placodes consist of thickened epithelium and underlying neural crest derived mesenchyme, and they function as the first signaling centers of the tooth
MP:0000118	arrest of tooth development	failure of differentiation of the teeth
MP:0000119	abnormal tooth eruption	any anomaly in the developmental process in which a tooth moves in an axial and occlusal direction from its developmental position within the alveolar crypt in the jaw to its final functional position in the occlusal plane
MP:0000120	malocclusion	perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth
MP:0000121	failure of tooth eruption	inability of the teeth to grow into the oral cavity
MP:0000122	premature tooth eruption	early onset of the growth of the teeth out of the gums
MP:0000124	obsolete absent teeth	OBSOLETE. absence of some or all of the bony structures of the upper and lower jaws used in mastication
MP:0000125	absent incisors	absence of the pairs of long teeth that are the most anterior and prominent in the jaw
MP:0000126	brittle teeth	fragile and likely to break teeth
MP:0000127	degenerate molars	deterioration or loss over time of the molars
MP:0000128	growth retardation of molars	developmental delay of the growth of the molars
MP:0000129	ameloblast degeneration	a retrogressive impairment of function or destruction of the epithelial cells of the inner later of the enamel organ of the developing tooth
MP:0000130	abnormal trabecular bone morphology	any structural anomaly of bone that has a lattice-like or spongy structure; it is highly vascular and contains intercommunicating spaces filled with bone marrow
MP:0000131	abnormal long bone epiphysis morphology	any structural anomaly of the rounded end of a long bone
MP:0000132	thickened long bone epiphysis	wider than normal rounded end of a long bone
MP:0000133	abnormal long bone metaphysis morphology	any structural anomaly of the conical section of bone between the epiphysis and diaphysis of the long bones; this section grows during childhood and juvenile stages and is completely ossified in adults
MP:0000134	abnormal compact bone thickness	reduced or increased width of the superficial layer of compact bone
MP:0000135	decreased compact bone thickness	thinner than normal superficial layer of compact bone
MP:0000136	abnormal microglial cell morphology	any structural anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques
MP:0000137	abnormal vertebrae morphology	any structural anomaly of the bony segments of the spinal column
MP:0000138	absent vertebrae	missing all of the bony segments of the spinal column
MP:0000139	absent vertebral transverse processes	loss of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes
MP:0000140	absent vertebral pedicles	loss of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae
MP:0000141	abnormal vertebral body morphology	any structural anomaly of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0000142	obsolete An Extra Piece of Bone Rostral to C1	OBSOLETE.
MP:0000143	obsolete Broadening/Splitting of the Neural Arch of C2	OBSOLETE.
MP:0000148	obsolete abnormal shoulder/ pelvic girdle morphology	OBSOLETE. any structural anomaly of the bones of the shoulder or of the bones of the pelvis by which the limbs attach to the axial skeleton
MP:0000149	abnormal scapula morphology	any structural anomaly of either or both of the large, flat bones of the back part of the shoulder
MP:0000150	abnormal rib morphology	any structural anomaly of the bones forming the bony wall of the chest
MP:0000151	absent ribs	absence of all the pairs of bony structures that make up the body wall
MP:0000152	absent proximal rib	missing part of rib structures near the spine, ribs do not contact vertebrae
MP:0000153	rib bifurcation	forking or division of ribs, may be a result of partial rib fusions
MP:0000154	rib fusion	appearance of one or more ribs as a single structure
MP:0000155	asymmetric rib joints	loss of bilateral symmetry in rib attachments to the vertebral column or to the sternum
MP:0000156	obsolete Presence of 6 Vertebrosternal Ribs instead of 7	OBSOLETE.
MP:0000157	abnormal sternum morphology	any structural anomaly of the long flat bone of the chest that articulates with clavicle and first seven rib pairs; from rostral to caudal positions, the sternum consists of three parts: manubrium, body, and xiphoid process
MP:0000158	absent sternum	missing long flat bone of the chest; articulates with clavicle and first seven rib pairs
MP:0000159	abnormal xiphoid process morphology	any structural anomaly of the caudal tip of the sternum
MP:0000160	kyphosis	forward curvature of the spine, characterized by extensive flexion
MP:0000161	scoliosis	lateral and rotational curvature of the spine
MP:0000162	lordosis	anteriorly convex curvature of the spine
MP:0000163	abnormal cartilage morphology	any structural anomaly of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life
MP:0000164	abnormal cartilage development	anomaly in the formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life
MP:0000165	abnormal long bone hypertrophic chondrocyte zone	anomaly of the layer of the epiphyseal plate of a long bone where chondrocytes mature and enlarge
MP:0000166	abnormal chondrocyte morphology	any structural anomaly of a polymorphic cell that forms cartilage
MP:0000167	decreased chondrocyte number	fewer than normal numbers of polymorphic cells that form cartilage
MP:0000168	abnormal bone marrow development	anomaly in the formation of the soft, pulpy tissue filling the medullary cavities of bones
MP:0000172	abnormal bone marrow cell number	increased or decreased number of cells that make up the core cavities of bones when compared to controls
MP:0000175	absent bone marrow cell	lack of all cells that make up the core cavities of bones
MP:0000176	obsolete bone marrow occupied by adipocytes	OBSOLETE. anomalous appearance of fat-forming cells in the bone marrow
MP:0000180	abnormal circulating cholesterol level	anomaly in the amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0000181	abnormal circulating LDL cholesterol level	any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions
MP:0000182	increased circulating LDL cholesterol level	greater amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions
MP:0000183	decreased circulating LDL cholesterol level	reduced amount in the blood of the lipoprotein:cholesterol complex that transports cholesterol out of the arteries and around the body, for use by various tissues in normal bodily functions
MP:0000184	abnormal circulating HDL cholesterol level	any anomaly in the amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion
MP:0000186	decreased circulating HDL cholesterol level	reduced amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion
MP:0000187	abnormal triglyceride level	any anomaly in the concentration of triglyceride, a glycerol esterified at each of its three hydroxyl groups by a fatty acid; triglyceride is an important molecule for storage of fatty acids in adipose tissue
MP:0000188	abnormal circulating glucose level	any anomaly in the concentration in the blood of the major monosaccharide of the body
MP:0000189	hypoglycemia	low levels of plasma glucose in the circulating blood; this generally refers to a pathological state
MP:0000192	abnormal mineral level	any anomaly in the concentration of any inorganic substance that has importance in body functions
MP:0000194	increased circulating calcium level	abnormally high concentration of calcium ions in the circulating blood
MP:0000195	decreased circulating calcium level	subnormal concentrations of calcium ions in the circulating blood
MP:0000198	decreased circulating phosphate level	abnormally low concentrations of phosphates in the circulating blood
MP:0000199	abnormal circulating serum albumin level	anomaly in the blood level of the major blood protein that is important in maintaining the colloidal osmotic pressure, fatty acid transport and transporting large organic molecules
MP:0000202	abnormal circulating alkaline phosphatase level	any anomaly in the concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters; low levels are seen in cases of hypophosphatasia
MP:0000203	abnormal circulating aspartate transaminase level	any anomaly in the concentration in the blood of the enzyme which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid
MP:0000208	decreased hematocrit	less than the average percentage of a volume of a blood sample occupied by red blood cells
MP:0000215	absent erythrocytes	lack of mature red blood cells
MP:0000216	absent erythroid progenitor cell	lack of progenitors of the erythrocyte lineage
MP:0000217	abnormal leukocyte cell number	any anomaly in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
MP:0000218	increased leukocyte cell number	greater than normal number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
MP:0000219	increased neutrophil cell number	greater than normal number of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes
MP:0000220	increased monocyte cell number	greater count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood
MP:0000221	decreased leukocyte cell number	reduction in the number of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
MP:0000222	decreased neutrophil cell number	reduced count of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes
MP:0000223	decreased monocyte cell number	reduced count of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood
MP:0000226	abnormal mean corpuscular volume	deviation from normal for the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices
MP:0000228	abnormal thrombopoiesis	abnormal development of the non-nucleated cells of the blood (platelets, thrombocytes) involved in blood coagulation
MP:0000229	abnormal megakaryocyte differentiation	atypical production of or inability to produce the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm
MP:0000230	abnormal systemic arterial blood pressure	altered tension of the blood within the systemic arteries
MP:0000231	hypertension	sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
MP:0000233	abnormal blood flow velocity	any anomaly in the rate of flow of the blood through vessels
MP:0000237	obsolete decreased blood cell number	OBSOLETE.  fewer than the normal numbers of the various types of blood cells
MP:0000238	absent pre-B cells	absence of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface
MP:0000239	absent common myeloid progenitor cells	lack of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages
MP:0000240	extramedullary hematopoiesis	formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes
MP:0000242	impaired fertilization	defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei
MP:0000243	myoclonus	involuntary shock-like contractions, variable in rhythm and amplitude, followed by relaxation, of a muscle or a group of muscles; generally due to a central nervous system lesion
MP:0000245	abnormal erythropoiesis	atypical process of the formation of enucleated fetal and adult erythrocytes
MP:0000247	obsolete abnormal interleukin-10 physiology	OBSOLETE. functional anomaly of this factor that is a co-regulator of mast cell growth and produced by T and B cells
MP:0000248	macrocytosis	condition in which erythrocytes are larger than normal in size
MP:0000249	abnormal blood vessel physiology	any functional anomaly of any of the tubes that convey blood including the arteries, arterioles, capillaries, venules, and veins
MP:0000250	abnormal vasoconstriction	anomaly in the narrowing of the blood vessels by smooth muscle contraction
MP:0000255	blood vessel congestion	obstruction of the normal flux of blood within the blood vessel network
MP:0000256	echinocytosis	a state in which the red blood cells have multiple small projections appearing over the cell circumference resembling a small burr or a sea urchin
MP:0000259	abnormal vascular development	aberrant process of vascular formation
MP:0000260	abnormal angiogenesis	aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network
MP:0000262	poor arterial differentiation	failure of or inadequate acquisition of the characteristics and/or functions of the arteries
MP:0000263	absent organized vascular network	formation of vasculature, but failure to differentiate into stereotypic organized pattern
MP:0000264	failure of vascular branching	failure of vasculature to form divisions (offshoots)
MP:0000265	blood vessel atresia	abnormal closure or absence of the lumen of one or more blood vessels
MP:0000266	abnormal heart morphology	any structural anomaly of the hollow, muscular organ that maintains the circulation of the blood
MP:0000267	abnormal heart development	aberrant formation or incomplete differentiation of the heart
MP:0000268	obsolete abnormal anterior cardiac development	OBSOLETE.
MP:0000269	abnormal heart looping	any anomaly in the characteristic morphogenetic movements where the primitive heart tube loops asymmetrically during early development; this looping brings the primitive heart chambers into alignment preceding their future integration
MP:0000270	abnormal heart tube morphology	any structural anomaly of the primitive epithelial cardiac tube before the division into the chambers of the mature heart
MP:0000272	abnormal aorta morphology	any structural anomaly of the main trunk of the systemic arterial system that originates from the base of the left ventricle of the heart and extends to the abdomen at the point where it branches into the common iliac arteries
MP:0000273	overriding aortic valve	congenitally abnormal position of the aorta where the valve origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left, frequently in conjunction with a ventricular septal defect
MP:0000274	enlarged heart	increase over normal size of the heart
MP:0000275	heart hyperplasia	increase in the number of normal cells in normal arrangement in the heart, typically resulting in increased size
MP:0000276	heart right ventricle hypertrophy	enlargement of heart right ventricular wall from the increase in size of its cells
MP:0000277	abnormal heart shape	any anomaly in the characteristic surface outline or contour of the heart
MP:0000278	abnormal myocardial fiber morphology	any structural anomaly of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0000279	ventricular hypoplasia	decrease in the number of normal cells in normal arrangement in the heart ventricle, typically resulting in decreased size
MP:0000280	thin ventricular wall	decreased depth of the cardiac wall of the heart ventricles
MP:0000281	abnormal interventricular septum morphology	any structural anomaly of the wall between the two lower chambers of the heart; the ventricular septum consists of a very small membranous portion just beneath the aortic valve, and a large thick muscular portion consisting of three sections including the inlet septum, the trabecular septum, and the outlet septum
MP:0000282	abnormal interatrial septum morphology	any structural anomaly of the thin membranous structure between the two heart atria
MP:0000284	double outlet right ventricle	both the aorta and the pulmonary trunk originate, either in whole or in part, from the right ventricle; often found in conjunction with a ventricular septal defect
MP:0000285	abnormal heart valve morphology	any structural anomaly of the membranous folds of the heart that prevent reflux of fluid
MP:0000286	abnormal mitral valve morphology	any structural anomaly of the valve that is located between the left atrium and the left ventricle of the heart, and contains two cusps, the anterior cusp and the posterior cusp, attached to the outer fibrous ring (annulus)
MP:0000287	heart valve hypoplasia	decrease in the number of normal cells in normal arrangement in any of the heart valves, typically resulting in decreased size
MP:0000288	abnormal pericardium morphology	any structural anomaly of the fibroserous membrane covering the heart and beginning of the great vessels
MP:0000291	enlarged pericardium	extended fibroserous membrane covering the heart and beginning of the great vessels
MP:0000292	distended pericardium	an expansion in the volume of the sac-like structure contained by the outer parietal layer of the pericardium
MP:0000293	absent myocardial trabeculae	absence of the supporting bundles of muscular fibers lining the walls of the heart
MP:0000295	trabecula carnea hypoplasia	decrease in the number of normal cells in normal arrangement in the supporting bundles of muscular fibers lining the walls of the ventricles of the heart, typically resulting in decreased size
MP:0000296	absent trabeculae carneae	missing supporting bundles of muscular fibers lining the walls of the ventricles of the heart
MP:0000297	abnormal atrioventricular cushion morphology	any structural anomaly of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices and the atrioventricular septum
MP:0000298	absent atrioventricular cushions	absence of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal
MP:0000299	failure of atrioventricular cushion closure	failure of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices
MP:0000300	thin atrioventricular cushion	reduced thickness of the mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal
MP:0000301	decreased atrioventricular cushion size	smaller than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal
MP:0000304	abnormal cardiac stroke volume	anomaly in the volume of blood pushed into the aorta with each beat of the heart
MP:0000306	obsolete abnormal pulse	OBSOLETE.
MP:0000307	obsolete abnormal heart sounds	OBSOLETE.
MP:0000313	abnormal cell death	any anomaly in the cessation of function at the cellular level
MP:0000314	schistocytosis	the appearance of poikilocytes in the blood that owe their abnormal shape to fragmentation occurring as the cells flow through damaged small vessels
MP:0000315	hemoglobinuria	the presence of hemoglobin in the urine, including certain closely related pigments that are formed from slight alteration of the hemoglobin molecule
MP:0000316	cellular necrosis	pathologic death of cells, usually from irreversible damage
MP:0000317	obsolete abnormal cell number	OBSOLETE. any anomaly in the numbers of cells
MP:0000318	obsolete increased cell number	OBSOLETE. greater than expected number of cells
MP:0000319	obsolete increased activated B cell number	OBSOLETE.
MP:0000321	increased bone marrow cell number	increased number of cells that make up the core cavities of bones when compared to the normal state
MP:0000322	increased granulocyte number	greater than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils
MP:0000324	increased mast cell number	greater than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation
MP:0000327	hemosiderinuria	the presence of hemosiderin in the urine; hemosiderin is an intracellular storage form of iron, found in the form of pigmented yellow to brown granules consisting of a complex of ferric hydroxides, polysaccharides, and proteins with an iron content of about 33 per cent by weight
MP:0000328	increased enterocyte cell number	greater than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen
MP:0000329	obsolete decreased cell number	OBSOLETE. fewer than expected number of cells
MP:0000330	obsolete decreased activated B cell number	OBSOLETE.
MP:0000332	hemoglobinemia	the presence of free hemoglobin in the blood plasma, an indication of significant intravascular hemolysis
MP:0000333	decreased bone marrow cell number	decreased number of cells that make up the core cavities of bones when compared to the normal state
MP:0000334	decreased granulocyte number	fewer than expected number of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils
MP:0000336	decreased mast cell number	fewer than expected number of the cells that are found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation
MP:0000339	decreased enterocyte cell number	fewer than expected number of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen
MP:0000340	obsolete absence of cell	OBSOLETE.
MP:0000341	abnormal bile color	any change in the color of the bile from the normal yellowish brown or green
MP:0000343	abnormal response to cardiac infarction	change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors
MP:0000344	absent Cajal-Retzius cell	the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus
MP:0000346	broad head	a greater ear- to -ear distance resulting in the appearance of a wide face and a flattened snout
MP:0000348	abnormal aerobic fitness	any change in the metabolism resulting in an altered ability to do physical work; for example, alterations in running capacity
MP:0000350	abnormal cell proliferation	anomaly in the ability of a cell population to undergo expansion by cell division
MP:0000351	increased cell proliferation	increase in the expansion rate of a cell population by cell division
MP:0000352	decreased cell proliferation	reduction in the expansion rate of a cell population by cell division
MP:0000353	obsolete Abnormal Cell Size	OBSOLETE.
MP:0000354	obsolete Increased Cell Size	OBSOLETE.
MP:0000355	obsolete Increased Purkinje Cell Size	OBSOLETE.
MP:0000356	obsolete Decreased Cell Size	OBSOLETE.
MP:0000357	obsolete Decreased Purkinje Cell Size	OBSOLETE.
MP:0000358	abnormal cell morphology	any structural anomaly of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms
MP:0000359	abnormal mast cell morphology	any structural anomaly of a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation
MP:0000360	obsolete absent metachromatic granules	OBSOLETE. lack of intracellular storage compartments that stain a different color than that of the dye used
MP:0000361	decreased mast cell protease storage	reduced amounts of proteolytic enzymes stored in mast cells
MP:0000362	decreased mast cell histamine storage	reduced amounts of histamine stored in mast cells
MP:0000363	obsolete Abnormal Cell Behavior	OBSOLETE.
MP:0000364	abnormal vascular regression	premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress
MP:0000365	obsolete Abnormal Hematopoietic/Hemopoietic/ Hematogenic/Hemogenic/Sanguifacient Cell Behavior	OBSOLETE.
MP:0000366	obsolete Impaired Proliferative Response of Hematopoietic Cells to Mitogens	OBSOLETE.
MP:0000367	abnormal coat/ hair morphology	any anomaly in the color, structure, growth, or texture of the hair
MP:0000370	head blaze	the appearance of a stripe of white fur on the head
MP:0000371	diluted coat color	a coat color that appears lighter in intensity or paler than normal
MP:0000372	irregular coat pigmentation	uneven coloration of the hair
MP:0000373	belly spot	the appearance of a round area of white fur on the belly
MP:0000374	obsolete pink fur hue	OBSOLETE. hairs have a prominent pink tinge
MP:0000376	folliculitis	inflammatory reaction in hair follicles
MP:0000377	abnormal hair follicle morphology	any structural anomaly of the invagination of the epidermis from which the hair shaft develops
MP:0000378	absent hair follicles	missing epidermal invaginations from which the hair shaft develops
MP:0000379	decreased hair follicle number	fewer number of the epidermal invaginations from which the hair shaft develops
MP:0000380	small hair follicles	reduced size of the invagination of the epidermis from which the hair shaft develops
MP:0000381	enlarged hair follicles	increased size of the epidermal invaginations from which the hair shaft develops
MP:0000382	underdeveloped hair follicles	arrest of or retarded differentiation of the epidermal invaginations from which the hair shaft develops
MP:0000383	abnormal hair follicle orientation	misaligned hair follicles; hair follicles that do not orient in a typical pattern
MP:0000384	distorted hair follicle pattern	twisted or contorted configuration of the arrangement of hair follicles in the skin
MP:0000386	obsolete abnormal hair follicle root sheath	OBSOLETE. anomalies of the epidermal-derived layer surrounding the hair follicle; innermost of two layers
MP:0000387	disorganized inner root sheath cells	disorganization of the epithelial cells that resides in the inner root sheath of the hair follicle
MP:0000388	absent hair follicle inner root sheath	absence of the multilayered tube composed of terminally differentiated hair follicle keratinocytes that is surrounded by the outer root sheath; the layers of the inner root sheath include the companion layer, Henle's layer, Huxley's layer and the inner root sheath cuticle
MP:0000389	disorganized outer root sheath cells	disordered enveloping layer of cells of the hair follicle; surrounds inner root and is continuous with basal and spinous layers of the epidermis
MP:0000390	disorganized matrix sheath cells	disordered layer of matrix cells of the hair follicle
MP:0000391	premature hair follicle generation	early onset of hair follicle development
MP:0000392	accelerated hair follicle regression	earlier onset of catagen phase during the cyclic transformation of the hair follicle
MP:0000393	persistent hair follicle morphogenesis	continuous induction of de novo hair follicles in the epidermis
MP:0000394	absent hair follicle melanin granules	absence of the pigment polymers located in the hair follicles
MP:0000395	obsolete abnormal hair types	OBSOLETE. any structural anomaly of the different subsets of types of hairs or change to the expected complement of different hair types
MP:0000396	increased curvature of hairs	greater bending arch of the distinct C- or S- shaped curvature of the hairs
MP:0000397	abnormal guard hair morphology	any structural anomaly of the long, straight truncal hairs that contain two air cells in the medulla
MP:0000398	splitting of guard hairs	intercellular splits and kinks within or along the hair shaft of the long, straight truncal hairs that contain two air cells in the medulla
MP:0000399	increased curvature of guard hairs	greater bending arch of the guard hairs
MP:0000400	abnormal awl hair morphology	any structural anomaly of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla
MP:0000401	increased curvature of awl hairs	greater bending arch of the awl hairs
MP:0000402	abnormal zigzag hair morphology	any structural anomaly or amount of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla
MP:0000403	increased curvature of zigzag hairs	greater bending arch of the zigzag hairs
MP:0000404	decreased curvature of zigzag hairs	smaller bending arch of the zigzag hairs
MP:0000405	abnormal auchene hair morphology	any structural anomaly of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla
MP:0000406	increased curvature of auchene hairs	greater bending arch of the auchene hairs
MP:0000407	abnormal duvet hair morphology	any structural anomaly of the fine under hair of the coat
MP:0000408	absent duvet hair	absence of the of the fine under hair of the coat
MP:0000410	waved hair	hair or fur having undulations or a sinusoidal shape
MP:0000411	shiny fur	fur with a glossy or glistening appearance
MP:0000412	excessive hair	greater amount of body hair compared to controls
MP:0000413	polyphalangy	increased number of phalanges in any of the digits
MP:0000414	alopecia	absence of hair due to loss of hair; not in reference to primary genetic hairlessness but may be due to dietary, stress or secondary to immune condition
MP:0000416	sparse hair	body hair that is less dense; may be due to reduced follicle numbers or due to the inability to retain some of the hairs of the coat over time
MP:0000417	short hair	reduced average length of the hairs
MP:0000418	focal hair loss	focal absence of hair in areas where hair is normally expected; in rodents, often appearing behind the ears and on the tail, resulting in visible patches of skin and uneven spots of hair growth on the body
MP:0000419	obsolete rough hair	OBSOLETE. greasy, matted appearance of the fur
MP:0000420	ruffled hair	fuzzy, irregular appearance of the hair
MP:0000421	mottled coat	coat has spots, streaks, and/or blotches of a different color
MP:0000422	delayed hair appearance	late onset of the first appearance of the fur
MP:0000423	delayed hair regrowth	slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase
MP:0000424	retarded hair growth	slow growth of the hair, appears at normal time
MP:0000425	loss of eyelid cilia	inability to retain the eyelashes
MP:0000426	ectopic hair growth	positional abnormality of hair
MP:0000427	abnormal hair cycle	aberrant timing of growth and regression of the hair follicles
MP:0000428	abnormal craniofacial morphology	any structural anomaly of the face or head affecting appearance
MP:0000430	absent maxillary shelf	missing bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate
MP:0000431	absent palatine bone horizontal plate	missing bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate
MP:0000432	abnormal head morphology	any structural anomaly of the portion of the body containing the brain and organs of sight, hearing, taste, and smell
MP:0000433	microcephaly	an abnormally small head
MP:0000434	megacephaly	an abnormally large size of the head
MP:0000435	shortened head	reduced anterior-posterior length of the head
MP:0000436	abnormal head movements	any anomaly in the motion of the portion of the body containing the brain and organs of sight, hearing, taste, and smell
MP:0000437	taut facial appearance	skin of face has appearance of being drawn or pulled tightly
MP:0000438	abnormal cranium morphology	any structural anomaly of the bones of the head
MP:0000439	enlarged cranium	increased size of the cranium
MP:0000440	domed cranium	increased curvature to the hemispherical shape of the upper cranial case
MP:0000441	increased cranium width	having an increased side-to-side, or lateral distance of the cranium
MP:0000443	abnormal snout morphology	any structural anomaly of the anterior facial part of the face or muzzle containing the oral and nasal regions
MP:0000445	short snout	reduced length of the anterior facial part of the muzzle
MP:0000446	long snout	the anterior facial part of the muzzle having a length greater than seen in controls
MP:0000447	flattened snout	a snout flattened laterally along the whole length without the appearance of distinctive curvature
MP:0000448	pointed snout	muzzle tapers to a small tip, sharper angle than wild type
MP:0000449	broad nasal bridge	wider than normal upper part of the ridge of the nose
MP:0000450	absent snout	absence of the anterior facial part of the face or muzzle containing the oral and nasal regions
MP:0000451	scaly muzzle	loss of the outer layer of the epidermis of the muzzle in thick, dry scale-like patches
MP:0000452	abnormal mouth morphology	any structural anomaly of the proximal portion of the digestive tract containing the oral cavity and bounded by the oral opening
MP:0000453	absent mouth	congenital absence of the mouth
MP:0000454	abnormal jaw morphology	any structural anomaly of the bony framework of the mouth where the teeth are held
MP:0000455	abnormal maxilla morphology	any structural anomaly of the upper bony framework of the mouth where the superior teeth are held
MP:0000457	maxilla hypoplasia	decrease in the number of normal cells in normal arrangement in the maxilla, typically resulting in decreased size
MP:0000458	abnormal mandible morphology	any structural anomaly of the lower bony framework of the mouth where the inferior teeth are held
MP:0000459	abnormal presacral vertebrae morphology	any structural anomaly of the vertebrae anterior to the sacrum
MP:0000460	mandible hypoplasia	decrease in the number of normal cells in normal arrangement in the mandible, typically resulting in decreased size
MP:0000461	decreased presacral vertebrae number	reduced number of the vertebrae anterior to the sacrum
MP:0000462	abnormal digestive system morphology	any structural anomaly of the system dedicated to the mechanical, chemical, and enzymatic processing of food
MP:0000464	increased presacral vertebrae number	greater number of the vertebrae anterior to the sacrum
MP:0000465	gastrointestinal hemorrhage	bleeding in the stomach and/or the intestines
MP:0000466	esophageal epithelium hyperplasia	increase in the number of normal cells in normal arrangement in the esophageal epithelium, typically resulting in increased size
MP:0000467	abnormal esophagus morphology	any structural anomaly of the part of the digestive canal through which food passes from the pharynx to the stomach
MP:0000468	abnormal esophageal epithelium morphology	any structural anomaly of the epithelial layer that lines the luminal space of the esophagus
MP:0000469	abnormal esophageal squamous epithelium morphology	any structural anomaly of the scaly epithelial layer of the esophagus
MP:0000470	abnormal stomach morphology	any structural anomaly of the hollow, sac-like structure of the digestive canal between the esophagus and the small intestine that functions to emulsify food
MP:0000471	abnormal stomach epithelium morphology	any structural anomaly of the epithelial layer of the stomach
MP:0000472	abnormal stomach non-glandular epithelium morphology	any structural anomaly of the squamous epithelium that lines the distinct rodent non-glandular region of the stomach, i.e. the forestomach (aka anterior or proximal stomach); in neonatal and adult mice, this epithelium is stratified, fully keratinized, and devoid of gastric glands
MP:0000473	abnormal stomach glandular epithelium morphology	any structural anomaly of the gland-containing epithelial layer of the stomach
MP:0000474	abnormal foregut morphology	any structural anomaly of the anterior portion of the primitive digestive tube of the embryo that lies cephalic to the junction of the yolk stalk, consists of endodermal tissue, and gives rise to the pharynx, lower respiratory system, esophagus, stomach, duodenum proximal to the biliary tract, liver, pancreas, biliary tract, and gall bladder
MP:0000476	obsolete thickening of bowel wall	OBSOLETE.
MP:0000477	abnormal intestine morphology	any structural anomaly of the digestive tube passing from the stomach to the anus, consisting of the small and large intestine divisions
MP:0000478	delayed intestine development	slowed progression to a structurally mature intestine
MP:0000479	abnormal enterocyte morphology	any structural anomaly of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen
MP:0000480	increased rib number	greater than normal numbers of the pairs of bony structures that are elements of the body wall
MP:0000481	abnormal enterocyte cell number	deviation from the normal numbers of enterocytes
MP:0000482	long fibula	increased length of the lateral and smaller of bone of the lower leg
MP:0000483	obsolete Increased intestinal cell number	OBSOLETE.
MP:0000484	abnormal pulmonary artery morphology	any structural anomaly of the artery that arises from the right ventricle and conveys unaerated blood to the lungs
MP:0000485	obsolete Decreased intestinal cell number	OBSOLETE.
MP:0000486	abnormal pulmonary trunk morphology	any structural anomaly of the region of the pulmonary artery that arises from the right ventricle to the division of the right and left pulmonary artery
MP:0000487	absent enterocytes	absence of the epithelial cells that have an apical plasma membrane folded into microvilli to provide ample surface for the absorption of nutrients from the intestinal lumen
MP:0000488	abnormal intestinal epithelium morphology	any structural anomaly of the cellular avascular layer of the digestive tube passing from the stomach to the anus
MP:0000489	abnormal large intestine morphology	any structural anomaly of the portion of the digestive tube extending from the ileocecal valve to the anus, consisting of the cecum, colon, rectum and anal canal
MP:0000490	abnormal crypts of Lieberkuhn morphology	any structural anomaly of the tubular intestinal glands found in the mucosal membranes
MP:0000491	crypts of Lieberkuhn abscesses	an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis
MP:0000492	abnormal rectum morphology	any structural anomaly of the terminal portion of the intestinal tube adjacent to the anus
MP:0000493	rectal prolapse	downward movement and external appearance of the rectum through the anus
MP:0000494	abnormal cecum morphology	any structural anomaly of the large sac at the ileum and large intestine junction
MP:0000495	abnormal colon morphology	any structural anomaly of the portion of the large intestine between the cecum and the rectum
MP:0000496	abnormal small intestine morphology	any structural anomaly of the portion of the digestive tube between the stomach and the cecum, consisting of the duodenum, ileum and jejunum
MP:0000497	abnormal small intestine placement	different location or arrangement of the small intestinal tract
MP:0000498	absent jejunum	missing portion of the small intestine that extends from the duodenum to the ileum
MP:0000499	absent ileum	missing portion of the small intestine that extends from the jejunum to the colon
MP:0000500	small intestinal prolapse	the descent of the small intestine through a weakness in the supporting tissues at the apex of the vagina gives rise to an enterocele, frequently caused by a weakness or separation of the cardinal and sacro-uterine ligaments
MP:0000501	abnormal digestive secretion	anomaly in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system
MP:0000502	obsolete abnormal digestive mucosecretion	OBSOLETE. malfunctioning of the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system
MP:0000503	excessive digestive secretion	increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system
MP:0000504	obsolete excessive digestive mucosecretion	increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system
MP:0000505	decreased digestive secretion	reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system
MP:0000506	obsolete decreased digestive mucosecretion	reduction in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system
MP:0000507	absent digestive secretion	failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system
MP:0000508	right-sided isomerism	anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the right side of the body; this may also be associated with absence of the spleen
MP:0000509	obsolete absent digestive mucosecretion	failure to produce and/or release a physiologically active substance (usually but not exclusively in liquid form) from the mucous membrane of the digestive system
MP:0000510	remittent intestinal hemorrhage	loss of blood from the intestines that is characterized by temporary periods of abatement
MP:0000511	abnormal intestinal mucosa morphology	any structural anomaly of the mucous lining of the intestine; this consists of epithelium, lamina propria, and a layer of smooth muscle cells
MP:0000512	intestinal ulcer	lesions in the mucous lining of the intestine
MP:0000513	obsolete infiltration of lymphocytes/plasma cells	OBSOLETE.
MP:0000516	abnormal renal/urinary system morphology	any structural anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism
MP:0000519	hydronephrosis	dilation of the pelvis and calices of one or both kidneys
MP:0000520	absent kidney	absence of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine
MP:0000521	abnormal kidney cortex morphology	any structural anomaly of the outer portion of the kidney located between the renal capsule and the renal medulla and involved in ultrafiltration; it contains the renal corpuscles, the renal tubules (except for parts of the loop of Henle which descend into the renal medulla), blood vessels and cortical collecting ducts
MP:0000522	kidney cortex cyst	presence of one or more abnormal membranous sacs in the kidney cortex
MP:0000523	cortical renal glomerulopathies	any disease of the capillary plexus in the kidney cortex
MP:0000524	decreased renal tubule number	fewer of the loops of Henle, the proximal convoluted tubules or the distal convoluted tubules
MP:0000525	renal tubular acidosis	a clinical syndrome characterized by the inability to acidify urine
MP:0000526	small inner medullary pyramid	reduced size of pyramidal masses; contain part of the secreting tubules and collecting tubules
MP:0000527	abnormal kidney development	any anomaly in the differentiation of the paired organs responsible for urine secretion
MP:0000528	delayed kidney development	late onset of the induction and/or differentiation of the kidney
MP:0000530	abnormal kidney vasculature morphology	any structural anomaly of the network of tubes that carries blood through the organ of excretion
MP:0000531	right pulmonary isomerism	anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the right side of the body
MP:0000532	kidney vascular congestion	obstruction of the normal flux of blood within the blood vessel network of the organ of secretion
MP:0000533	kidney hemorrhage	bleeding in the organ of excretion
MP:0000534	abnormal ureter morphology	any structural anomaly of the tube that conducts the urine from the renal pelvis to the bladder
MP:0000535	ureter urothelium hyperplasia	increase in the number of normal cells in normal arrangement in the ureter urothelium, typically resulting in increased size
MP:0000536	hydroureter	distention of the ureter with urine, due to blockage from any cause
MP:0000537	abnormal urethra morphology	any structural anomaly of the fibromuscular tubular canal through which urine is discharged from the bladder to the exterior via the external urinary meatus; in males, the urethra is joined by the ejaculatory ducts and serves as a passageway for semen during ejaculation, as well as a canal for urine during voiding; in females, the urethra is shorter and emerges above the vaginal opening
MP:0000538	abnormal urinary bladder morphology	any structural anomaly of the distensible musculomembranous organ that serves to collect and store urine excreted by the kidneys
MP:0000539	distended urinary bladder	stretched musculomembranous organ that serves to collect and store urine excreted by the kidneys
MP:0000540	abnormal urinary bladder urothelium morphology	any structural anomaly of the epithelial lining of the luminal space of the urinary bladder
MP:0000541	obsolete abnormal urinary bladder transitional epithelium morphology	any structural anomaly of the transitional epithelial layer of the urinary bladder
MP:0000542	left-sided isomerism	anomaly in the asymmetry of the visceral paired organs (e.g. lungs) such that organs on the left and right side have the morphology normally seen on the left side of the body; this may also be associated with the presence of multiple spleens
MP:0000543	absent urinary bladder urothelium	missing the transitional epithelial layer of the urinary bladder
MP:0000544	thin urinary bladder urothelium	decrease in the thickness of the transitional epithelial layer of the urinary bladder
MP:0000545	obsolete abnormal limbs/digits/tail morphology	OBSOLETE. morphological or developmental anomaly of the digits, autopod, limbs, or tail
MP:0000547	short limbs	reduced average length of the extremities
MP:0000548	long limbs	increased average length of the extremities
MP:0000549	absent limbs	absence of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species
MP:0000550	abnormal forelimb morphology	any structural anomaly of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species
MP:0000551	absent forelimb	absence of the projecting rostral-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm or front limb in mammalian species
MP:0000552	abnormal radius morphology	any structural anomaly of the short bone of the lateral forearm
MP:0000553	absent radius	missing the short bone of the lateral forearm
MP:0000554	abnormal carpal bone morphology	any structural anomaly of the nine nodular bones of the joint between the forelimb bones and the front paws/hands consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids
MP:0000555	absent carpal bone	absence of any or all of the nine nodular bones of the joint between the forelimb bones and the front paws/hands, consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids
MP:0000556	abnormal hindlimb morphology	any structural anomaly of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species
MP:0000557	absent hindlimb	absence of the projecting caudal-most paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the legs or back limbs in mammalian species
MP:0000558	abnormal tibia morphology	any structural anomaly of the medial and larger of the two bones of the lower leg
MP:0000559	abnormal femur morphology	any structural anomaly of the long bone of the thigh
MP:0000561	adactyly	missing one or more digits, or all digits
MP:0000562	polydactyly	greater than the normal complement of digits on one or more autopods
MP:0000564	syndactyly	any degree of webbing or fusion of the digits, may involve only soft tissues or also can include bone
MP:0000565	oligodactyly	congenital condition in which some digits or parts of digits are missing
MP:0000566	synostosis	osseous union of two bones that are not normally connected
MP:0000567	truncated digits	absence of the most distal region of the digits
MP:0000568	ectopic digits	positional abnormality of a digit
MP:0000569	abnormal digit pigmentation	anomaly in the coloration of the fingers or toes due to changes in the amount, shape, or distribution of cells producing pigment
MP:0000571	interdigital webbing	fold of skin, or web, between the toes that is not normally present
MP:0000572	abnormal autopod morphology	any structural anomaly of the distal elements of the limb of vertebrates including the pedal or prehensile appendages (e.g. hand, foot, paw, phalanges and/or digits)
MP:0000573	increased hindlimb autopod size	larger than average size of the rear feet
MP:0000574	abnormal foot pad morphology	any structural anomaly of the body of fat on the foot
MP:0000575	increased foot pad pigmentation	darker color of the foot pads due to excess pigment
MP:0000576	clubfoot	congenital deformation of the autopods; hind or forelimb foot is plantarflexed, inverted and adducted
MP:0000577	absent eccrine glands	absence of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans
MP:0000578	ulcerated autopod	inflammatory, often suppurating lesions on the paws; often become necrotic
MP:0000579	abnormal nail morphology	any structural anomaly of any of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits
MP:0000580	deformed nails	atypical shape or size of the nails
MP:0000581	obsolete ventral nails/ hair	OBSOLETE. appearance of nails and hair on the ventral side of the paw
MP:0000582	toenail hyperkeratosis	keratin extensions from the toenails
MP:0000583	long toenails	increased length of the toenails
MP:0000585	kinked tail	a sharp bend or zigzag in the tail
MP:0000588	thick tail	a tail with a greater diameter than normal
MP:0000589	thin tail	a tail with a smaller diameter than normal
MP:0000592	short tail	reduced length of tail compared to control
MP:0000593	obsolete tail band	OBSOLETE.
MP:0000596	abnormal liver development	any anomaly in the differentiation of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage
MP:0000597	delayed hepatic development	late onset of the induction and/or differentiation of the liver
MP:0000598	abnormal liver morphology	any structural anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage
MP:0000599	enlarged liver	larger than average size of the liver
MP:0000600	liver hypoplasia	decrease in the number of normal cells in normal arrangement in the liver, typically resulting in decreased size
MP:0000601	small liver	reduced size of the liver
MP:0000602	dilated liver sinusoidal space	the luminal space of one or more liver sinusoids is increased in volume or area
MP:0000603	pale liver	liver lacking normal coloration, often refers to bloodless condition
MP:0000604	amyloidosis	an accumulation of extracellular amyloid deposits in tissues of the body
MP:0000606	decreased hepatocyte number	fewer than normal number of parenchymal liver cells
MP:0000607	abnormal hepatocyte morphology	any structural anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules
MP:0000608	dissociated hepatocytes	disorganization of cohesive hepatocyte structure
MP:0000609	abnormal liver physiology	any functional anomaly of the bile-secreting organ that is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage
MP:0000610	cholestasis	impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis)
MP:0000611	jaundice	clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes
MP:0000612	obsolete sclerosis	OBSOLETE.
MP:0000613	abnormal salivary gland morphology	any structural anomaly of the saliva-secreting glands of the oral cavity
MP:0000614	absent salivary gland	missing any of the saliva-secreting glands of the oral cavity
MP:0000615	abnormal palatine gland morphology	any structural anomaly of the salivary gland of the hard palate
MP:0000616	decreased ductal branching in the palatine gland	fewer branches and distal tips of the vesicles of the palatine gland
MP:0000617	increased salivary gland mucosal cell number	greater than normal number of cells that form mucus in the salivary glands
MP:0000618	small salivary gland	reduced size of the saliva-secreting glands of the oral cavity
MP:0000619	salivary gland epithelial hyperplasia	increase in the number of normal cells in normal arrangement in the salivary gland epithelium, typically resulting in increased size
MP:0000620	narrow salivary ducts	reduced diameter of the tubular canals that carry saliva
MP:0000621	increased salivary adenocarcinoma incidence	greater than the expected number of a malignant neoplasm of the secreting cells of the salivary gland, occurring in a specific population in a given time period
MP:0000622	increased salivation	greater than normal amounts of flowing saliva
MP:0000623	decreased salivation	reduction in the flow, secretion, or amount of saliva
MP:0000624	xerostomia	dryness of the mouth resulting from reduced salivary secretion
MP:0000627	abnormal mammary gland morphology	any structural anomaly of the compound, alveolar and apocrine accessory gland of the skin of mammals that secretes milk
MP:0000628	abnormal mammary gland development	aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity
MP:0000629	absent mammary gland	absence of the specialized accessory gland of the skin of mammals that secretes milk
MP:0000630	mammary gland hyperplasia	increase in the number of normal cells in normal arrangement in the mammary gland, typically resulting in increased size
MP:0000631	abnormal neuroendocrine gland morphology	any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and that release hormones in response to neural stimuli
MP:0000632	abnormal pineal gland morphology	any structural anomaly of the unpaired epithalamic structure that is shaped like a tiny pine cone and located above the posterior commissure near the level of the habenular complex and the sylvian aqueduct; it is both a circumventricular organ and an endocrine organ that secretes melatonin, a serotonin-derived hormone involved in the regulation of circadian rhythms; the pineal parenchyma, consisting of pinealocytes, interstitial (glial-like) cells, phagocytes and capillaries, is arranged into large folliculi separated by septae of connective tissue and blood vessels
MP:0000633	abnormal pituitary gland morphology	any structural anomaly of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin from the anterior lobe; melanocyte stimulating hormone from the intermediate lobe and hormones involved in blood pressure regulation from the posterior lobe
MP:0000635	pituitary gland hyperplasia	increase in the number of normal cells in normal arrangement in the pituitary gland, typically resulting in increased size
MP:0000636	enlarged pituitary gland	increased size of pituitary gland
MP:0000637	obsolete abnormal merkel cells	OBSOLETE.
MP:0000638	obsolete hyperproliferation of merkel cells	OBSOLETE.
MP:0000639	abnormal adrenal gland morphology	any structural anomaly of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla
MP:0000640	adrenal gland hypoplasia	decrease in the number of normal cells in normal arrangement in the adrenal gland, typically resulting in decreased size
MP:0000642	enlarged adrenal glands	increased size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla
MP:0000643	absent adrenal medulla	absence of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine
MP:0000644	dextrocardia	congenital defect in which the heart is located on the right side of the thorax instead of on the left side (levocardia, the normal position)
MP:0000645	absent adrenergic chromaffin cells	absence of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion
MP:0000646	enlarged adrenocortical cells	larger size of cells of the steroid hormone-producing cells of the cortex of the adrenal gland
MP:0000647	abnormal sebaceous gland morphology	any structural anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts
MP:0000648	absent sebaceous gland	absence of the holocrine glands of the dermis that secrete sebum into the hair follicles
MP:0000649	sebaceous gland atrophy	acquired diminution of the size of the holocrine glands of the dermis that secrete sebum into the hair follicles, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0000650	mesocardia	congenital defect in which the heart is located in the middle of the thorax instead of on the left side (levocardia, the normal position)
MP:0000652	enlarged sebaceous gland	increased size of the sebum secreting glands of the hair shaft
MP:0000653	abnormal sex gland morphology	any structural anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction
MP:0000654	absent sex gland	missing any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction
MP:0000655	dilated sex gland	stretched appearance or excessive fluid in one or more sex glands
MP:0000659	prostate gland hyperplasia	increase in the number of normal cells in normal arrangement in the prostate gland, typically resulting in increased size
MP:0000660	prostate gland lateral lobe hypoplasia	decrease in the number of normal cells in normal arrangement in the prostate gland lateral lobe, typically resulting in decreased size
MP:0000661	small prostate gland ventral lobe	reduced size of the rodent prostate lobe that is located below the ventral aspect of the bladder neck
MP:0000662	abnormal branching of the mammary ductal tree	anomaly in the development of the channels that secrete milk and direct milk to the nipple
MP:0000664	small prostate gland anterior lobe	reduced size of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles
MP:0000665	decreased ductal branching in the coagulating gland	fewer branches and distal tips of the vesicles of the coagulating gland
MP:0000666	decreased prostate gland duct number	fewer than normal minute canals that pass the prostatic secretions to the urethra
MP:0000671	bulbourethral gland hypoplasia	decrease in the number of normal cells in normal arrangement in the bulbourethral gland, typically resulting in decreased size
MP:0000672	obsolete decreased mucin cell number	OBSOLETE. fewer than normal number of cells that secrete fluid containing carbohydrate-rich glycoproteins
MP:0000674	abnormal sweat gland morphology	any structural anomaly of any of the coil glands of the skin that secrete sweat
MP:0000675	abnormal eccrine sweat gland morphology	any structural anomaly of the coiled tubular glands situated on the digits and footpads of the paws of rodents, and both in the histologically thick skin of the palmar and plantar surfaces and in the thin skin that covers most of the rest of the body in humans; in mice these are the only sweat glands present
MP:0000676	abnormal body water content	more or less than the normal total amount of water retained in the body
MP:0000678	abnormal parathyroid gland morphology	any structural anomaly of one of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0000679	increased percent water in carcass	more than the normal total amount of water retained in the body measured post mortem
MP:0000680	absent parathyroid glands	missing the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland, which secrete parathyroid hormone (PTH)
MP:0000681	abnormal thyroid gland morphology	any structural anomaly of the endocrine gland located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin
MP:0000683	decreased percent water in carcass	less than the normal total amount of water retained in the body measured post mortem
MP:0000685	abnormal immune system morphology	any structural anomaly in the organs or cells associated with the development and formation of lymphocytes
MP:0000687	small lymphoid organs	reduced size of lymphatic tissues
MP:0000688	lymphoid hyperplasia	increase in the number of normal cells in normal arrangement in the lymphoid tissue, typically resulting in increased size
MP:0000689	abnormal spleen morphology	any structural anomaly of the organ that functions to filter blood and to store red corpuscles and platelets
MP:0000690	absent spleen	missing organ that functions to filter blood and to store red corpuscles and platelets
MP:0000691	enlarged spleen	increased spleen size
MP:0000692	small spleen	decreased spleen size
MP:0000693	spleen hyperplasia	increase in the number of normal cells in normal arrangement in the spleen, typically resulting in increased size
MP:0000694	spleen hypoplasia	decrease in the number of normal cells in normal arrangement in the spleen, typically resulting in decreased size
MP:0000696	abnormal Peyer's patch morphology	any structural anomaly of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0000697	obsolete more prevalent Peyer's patches	OBSOLETE. greater or more obvious numbers of Peyer's patches
MP:0000698	obsolete less prevalent Peyer's patches	OBSOLETE. fewer or less obvious numbers of Peyer's patches
MP:0000700	abnormal lymph node number	deviation from the normal number of lymph nodes
MP:0000701	abnormal lymph node size	deviation from the normal lymph node size
MP:0000702	enlarged lymph nodes	lymph nodes of increased size
MP:0000703	abnormal thymus morphology	any structural anomaly of the primary lymphoid organ that is required for maturation of T cells and secretion of thymosins, hormones that stimulate the development of antibodies; the thymus also stimulates the production of certain pituitary gland hormones that promote growth and sexual maturation
MP:0000704	abnormal thymus development	anomaly in the formation and/or differentiation of the thymus
MP:0000705	athymia	absence of the primary lymphoid organ
MP:0000706	small thymus	reduced size of the thymus
MP:0000708	thymus hyperplasia	increase in the number of normal cells in normal arrangement in the thymus, typically resulting in increased size
MP:0000709	enlarged thymus	increased size of thymus
MP:0000711	thymus cortex hypoplasia	decrease in the number of normal cells in normal arrangement in the tymus cortex, typically resulting in decreased size
MP:0000712	obsolete abnormal thymocyte	OBSOLETE.
MP:0000713	obsolete abnormal thymocyte number	OBSOLETE.
MP:0000714	increased thymocyte number	greater than expected number of immature T cells located in the thymus
MP:0000715	decreased thymocyte number	fewer than expected number of immature T cells located in the thymus
MP:0000716	abnormal immune system cell morphology	any structural anomaly of immune cells
MP:0000717	abnormal lymphocyte cell number	deviation from the normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
MP:0000726	absent lymphocyte	absence of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
MP:0000727	absent CD8-positive, alpha-beta T cells	lack of the set of single-positive T cells that express CD8 on their surface
MP:0000729	abnormal myogenesis	anomaly in embryonic formation of muscle cells or fibers
MP:0000730	increased satellite cell number	greater number of unfused cells in muscle that play a role in muscle regeneration
MP:0000731	increased collagen deposition in the muscles	accumulation of collagen within the muscles
MP:0000732	delayed primary myocyte appearance	development of initial muscle cells at a later time than is normal
MP:0000733	abnormal muscle development	any anomaly in the differentiation of muscle tissue
MP:0000734	muscle hypoplasia	decrease in the number of normal cells in normal arrangement in the muscle, typically resulting in decreased size
MP:0000736	delayed muscle development	late onset of the induction and/or differentiation of skeletal muscle
MP:0000737	abnormal myotome development	malformation of or absence of the part of the somite that develops into the musculature
MP:0000738	impaired muscle contractility	inability or reduced ability of a muscle to shorten or to develop increased tension
MP:0000740	impaired smooth muscle contractility	inability or reduced ability of the smooth muscle to shorten or to develop increased tension
MP:0000741	impaired contractility of urinary bladder detrusor smooth muscle	inability or reduced ability of the detrusor smooth muscle of the urinary bladder to shorten or to develop increased tension voluntarily or involuntarily; stretching of the smooth muscle fibers by accumulation of urine in the bladder leads to nervous signaling giving the urge to urinate; contraction of the detrusor muscle leads to urination, via emptying of the urine contained in the bladder through the urethra and urine excretion
MP:0000742	impaired contractility of ileal smooth muscle	inability or reduced ability of the ileal smooth muscle to shorten or to develop increased tension
MP:0000743	muscle spasm	an involuntary and often painful muscle contraction or cramps having a number of causes ranging from nutritional deficiency to serious nervous system conditions
MP:0000745	tremors	repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement
MP:0000746	weakness	state of being infirm or less strong than normal
MP:0000747	muscle weakness	loss of muscle strength
MP:0000748	progressive muscle weakness	increasing loss of muscle strength over time
MP:0000749	muscle degeneration	pathological deterioration of muscle tissue, often accompanied by loss of function
MP:0000750	abnormal muscle regeneration	anomaly in the renewal, repair, and/or regrowth of muscle tissue following injury or disease
MP:0000751	myopathy	any abnormal condition or disease of the skeletal muscle
MP:0000752	dystrophic muscle	progressive weakness and wasting of muscle
MP:0000753	paralysis	severe or complete loss of power of voluntary movement in a muscle through injury or disease of its nerve supply
MP:0000754	paresis	mild or partial loss of power of voluntary movement in a muscle through injury or disease of it or its nerve supply
MP:0000755	hindlimb paralysis	severe or complete loss of power of voluntary movement in the muscles of the hindlimb through injury or disease of it or its nerve supply
MP:0000756	forelimb paralysis	severe or complete loss of power of voluntary movement in muscles of the forelimb through injury or disease of it or its nerve supply
MP:0000757	herniated abdominal wall	protrusions through and/or into the abdominal wall often resulting in the extrusion of viscera
MP:0000759	abnormal skeletal muscle morphology	any structural anomaly of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body
MP:0000761	thin diaphragm muscle	reduced thickness of the diaphragm muscle
MP:0000762	abnormal tongue morphology	any structural anomaly of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor
MP:0000763	abnormal filiform papillae morphology	any structural anomaly of the keratinized projections on the dorsal surface of the tongue
MP:0000764	abnormal tongue epithelium morphology	any structural anomaly of the epithelial layer of the tongue
MP:0000765	abnormal tongue squamous epithelium morphology	any structural anomaly of the scaly epithelial layer of the tongue
MP:0000766	absent tongue squamous epithelium	missing the scaly epithelial layer of the tongue
MP:0000767	abnormal smooth muscle morphology	any structural anomaly of any of the unstriated muscle fibers of the internal organs, blood vessels, hair follicles, etc.
MP:0000768	obsolete nervous system abnormalities	OBSOLETE. any malformation or anomaly in the entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses
MP:0000771	abnormal brain size	deviation from the average range of brain size for an organism
MP:0000774	decreased brain size	smaller appearance of the brain
MP:0000776	abnormal inferior colliculus morphology	any structural anomaly of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements
MP:0000777	increased inferior colliculus size	enlargement of the paired inferior eminence of the mesencephalic tectum
MP:0000778	abnormal nervous system tract morphology	any structural anomaly in the structure of any bundle of myelinated nerve fibers following a defined path through the brain and/or spinal cord
MP:0000779	obsolete gliosis of tract	OBSOLETE.
MP:0000780	abnormal corpus callosum morphology	any structural anomaly of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres
MP:0000781	decreased corpus callosum size	smaller thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres
MP:0000783	abnormal forebrain morphology	any structural anomaly of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)
MP:0000784	forebrain hypoplasia	decrease in the number of normal cells in normal arrangement in the forebrain, typically resulting in decreased size
MP:0000785	telencephalon hypoplasia	decrease in the number of normal cells in normal arrangement in the telencephalon, typically resulting in decreased size
MP:0000786	abnormal embryonic neuroepithelial layer differentiation	abnormal or arrest of differentiation or patterning of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells
MP:0000787	abnormal telencephalon morphology	any structural anomaly of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon
MP:0000788	abnormal cerebral cortex morphology	any structural anomaly of thin layer of grey matter on the surface of the cerebral hemisphere that folds into gyri; it is responsible for intellectual faculties and higher mental functions
MP:0000789	thickened cerebral cortex	increased depth of the mantle covering the surface of the cerebral hemispheres
MP:0000790	abnormal stratification in cerebral cortex	abnormal formation or pattern of the layers of the cerebral cortex
MP:0000791	delaminated cerebral cortex	splitting of the layers of the grey cellular mantle covering the surface of the brain
MP:0000792	abnormal cortical marginal zone morphology	any structural anomaly of the developing superficial cortical layer located just under the pia matter
MP:0000794	abnormal parietal lobe morphology	any structural anomaly of the upper central part of the cerebral hemisphere
MP:0000795	abnormal postcentral gyrus morphology	any structural anomaly of the area of the parietal lobe that receives general sensation from the body
MP:0000796	abnormal sensory dissociation area morphology	any structural anomaly of the area of the parietal lobe that integrates tactile and visual stimuli
MP:0000797	abnormal supramarginal gyrus morphology	any structural anomaly of the area of the frontal lobe that is involved in perception based on sensory stimuli
MP:0000798	abnormal frontal lobe morphology	any structural anomaly of the anterior part of the cerebral hemisphere
MP:0000799	abnormal precentral gyrus morphology	any structural anomaly of the area of the frontal lobe that contains the cell bodies of the primary motor pathways
MP:0000800	abnormal supplemetal motor cortex morphology	any structural anomaly of the area of the frontal lobe that is involved with integration of voluntary movements and with speech
MP:0000801	abnormal temporal lobe morphology	any structural anomaly of the lower lateral part of the cerebral hemisphere
MP:0000802	abnormal superior temporal gyrus morphology	any structural anomaly of one of three major convolutions of the external surface of the temporal lobe of the cerebral hemispheres that is uppermost and borders the lateral (sylvian) fissure, and contains the primary auditory cortex
MP:0000803	abnormal transverse gyrus of Heschl morphology	any structural anomaly of the area of the temporal lobe concerned with hearing
MP:0000804	abnormal occipital lobe morphology	any structural anomaly of the posterior part of the cerebral hemisphere
MP:0000805	abnormal visual cortex morphology	any structural anomaly of the area of the occipital cortex concerned with vision
MP:0000807	abnormal hippocampus morphology	any structural anomaly of the deep lying structure of the cerebrum involved with memory storage and spatial navigation
MP:0000808	abnormal hippocampus development	improper differentiation of the hippocampus
MP:0000809	absent hippocampus	missing convoluted brain structure below the cerebral hemispheres; forms part of the limbic system
MP:0000811	hippocampal neuron degeneration	a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus
MP:0000812	abnormal dentate gyrus morphology	any structural anomaly of one of two interlocking gyri of the hippocampus formation that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus
MP:0000813	abnormal hippocampus layer morphology	any structural anomaly of the layers of the laminar structure of the hippocampus
MP:0000814	absent dentate gyrus	lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers
MP:0000815	abnormal Ammon gyrus morphology	any structural anomaly of one or both of the two interlocking gyri of the hippocampus formation; a circonvolution of rhinencephalon, the grey substance of which is rich in big pyramidal neuronal cells
MP:0000816	obsolete abnormal hippocampal molecular layer morphology	OBSOLETE.
MP:0000818	abnormal amygdala morphology	any structural anomaly of the almond-shaped body of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe; this area is involved in aggression and fear responses
MP:0000819	abnormal olfactory bulb morphology	any structural anomaly of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex
MP:0000820	abnormal choroid plexus morphology	any structural anomaly of the infoldings of blood vessels of the pia mater covered by a thin coat of ependymal cells that form tufted projections into the third, fourth, and lateral ventricles of the brain; choroid plexuses secrete cerebrospinal fluid (CSF) and act as a filtration system, removing metabolic waste, foreign substances, and excess neurotransmitters from the CSF
MP:0000821	choroid plexus hyperplasia	increase in the number of normal cells in normal arrangement in the choroid plexus, typically resulting in increased size
MP:0000822	abnormal brain ventricle morphology	any structural anomaly of the system of four communicating cavities within the brain that are continuous with the central canal of the spinal cord
MP:0000823	abnormal lateral ventricle morphology	any structural anomaly of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle
MP:0000825	dilated lateral ventricle	the luminal space of one or both lateral ventricles is increased in volume or area, usually with an increase in contained fluid
MP:0000826	abnormal third ventricle morphology	any structural anomaly of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina
MP:0000827	dilated third ventricle	the luminal space of the third ventricle is increased in volume or area, usually with an increase in contained fluid, in the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina
MP:0000828	abnormal fourth ventricle morphology	any structural anomaly of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space
MP:0000829	dilated fourth ventricle	the luminal space of the fourth ventricle is increased in volume or area, usually with an increase in contained fluid, in the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space
MP:0000830	abnormal diencephalon morphology	any structural anomaly of the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex
MP:0000831	diencephalon hyperplasia	increase in the number of normal cells in normal arrangement in the diencephalon, typically resulting in increased size
MP:0000832	abnormal thalamus morphology	any structural anomaly of the large ovoid mass of paired bodies containing mostly grey matter and forming part of the lateral wall of the third ventricle of the brain
MP:0000833	thalamus hyperplasia	increase in the number of normal cells in normal arrangement in the thalamus, typically resulting in increased size
MP:0000834	abnormal subthalamus morphology	any structural anomaly of the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis
MP:0000835	abnormal subthalamic nucleus morphology	any structural anomaly of the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function
MP:0000836	abnormal substantia nigra morphology	any structural anomaly of the layer of grey substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)
MP:0000837	abnormal hypothalamus morphology	any structural anomaly of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release
MP:0000838	obsolete abnormal pituitary afferents	OBSOLETE.
MP:0000839	hypothalamus hyperplasia	increase in the number of normal cells in normal arrangement in the hypothalamus, typically resulting in increased size
MP:0000840	abnormal epithalamus morphology	any structural anomaly of the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle
MP:0000841	abnormal hindbrain morphology	any structural anomaly of the part of the brain developed from the posterior of the three primary brain vesicles of the embryonic neural tube from which the metencephalon and myelencephalon are derived; the metencephalon (anterior part of the embryonic hindbrain), gives rise to the cerebellum and pons while the myelencephalon (posterior portion of the embryonic hindbrain) gives rise to the medulla oblongata
MP:0000842	absent superior olivary complex	missing nucleus of neurons on the dorsal part of the lateral surface of the pons; it normally receives projection fibers from the cochlear nuclei and is prominently involved in spatial localization of sound
MP:0000843	absent facial nuclei	missing nucleus of neurons in the hindbrain; receives fibers from the facial muscles, stapedus muscle and stylohyoid muscle
MP:0000844	abnormal pontine flexure morphology	any structural anomaly of the dorsally concave bend of the embryonic rhombencephalon that produces a thinning of the roof of the pons and medulla oblongata and defines the boundary between the metencephalon and myelencephalon in the embryo
MP:0000846	abnormal medulla oblongata morphology	any structural anomaly in the most caudal region of the brainstem that lies directly rostral to the spinal cord; includes regions responsible for autonomic functions such as digestion, breathing and control of heart rate
MP:0000847	abnormal metencephalon morphology	any structural anomaly of the anterior part of the developing vertebrate hindbrain or the corresponding part of the adult brain composed of the cerebellum and the pons Varolii
MP:0000848	abnormal pons morphology	any structural anomaly of the band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum
MP:0000849	abnormal cerebellum morphology	any structural anomaly of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills
MP:0000850	absent cerebellum	missing the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement
MP:0000851	cerebellum hypoplasia	decrease in the number of normal cells in normal arrangement in the cerebellum, typically resulting in decreased size
MP:0000852	small cerebellum	reduced size of cerebellum
MP:0000853	absent cerebellar foliation	missing small branches of the cerebellar lobules
MP:0000854	abnormal cerebellum development	aberrant or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills
MP:0000855	accelerated formation of intralobular fissures	formation of the major fissures of the cerebellum earlier in development than normal
MP:0000856	abnormal cerebellar plate morphology	any structural anomaly of the embryonic pseudostratified epithelium of the fourth cerebellar ventricle that eventually forms the vermis and ventral neuroepithelium
MP:0000857	abnormal cerebellar foliation	any anomaly of the pattern of the ten cerebellar lobules; in mammals, the vermis portion of the cerebellum has a foliation pattern along the AP axis that is distinct from the lateral cerebellar hemispheres and the intermediate zone that separates the vermis from the lateral hemispheres; in addition, each of the ten basic lobules can be subdivided into sublobules but strain and species differences are reported
MP:0000858	abnormal metastatic potential	altered likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it
MP:0000859	abnormal somatosensory cortex morphology	any structural anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface
MP:0000860	abnormal primary somatosensory cortex morphology	any structural anomaly of the area of the postcentral gyrus and central sulcus that is involved in somatic sensation
MP:0000861	disorganized barrel cortex	derangement of the pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae
MP:0000862	absent barrels in primary somatosensory cortex	missing pattern of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae
MP:0000863	abnormal secondary somatosensory cortex morphology	any structural anomaly of the area of the upper bank of the lateral sulcus that is involved in somatic sensation
MP:0000864	abnormal cerebellum vermis morphology	any structural anomaly of the narrow medial zone between the two hemispheres of the cerebellum that is delimited by two longitudinal furrows; it may be continuous with the cerebellar hemispheres in some areas of the cerebellum, e.g., dorsally, or separated by deeper fissues in others (e.g., ventrally); it receives inputs from the spinocerebellar tracts which carry to the vermis information on the position and balance of the torso, and it sends projections to the fastigial nucleus of the cerebellum, which then sends output to the vestibular nuclei
MP:0000865	absent cerebellum vermis	missing narrow middle zone between the two hemispheres of the cerebellum
MP:0000866	cerebellum vermis hypoplasia	decrease in the number of normal cells in normal arrangement in the cerebellum vermis, typically resulting in decreased size
MP:0000867	abnormal cerebellum anterior vermis morphology	any structural anomaly of the anterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located anterior to the primary fissure
MP:0000868	decreased anterior vermis size	smaller appearance of the narrow middle zone between the two hemispheres of the anterior lobe of the cerebellum
MP:0000869	abnormal cerebellum posterior vermis morphology	any structural anomaly of the posterior portion of the narrow middle zone between the two hemispheres of the cerebellum that is located posterior to the primary fissure
MP:0000870	absent cerebellum vermis lobule VIII	missing part of the inferior vermis of the cerebellum (vermis lobule VIII)
MP:0000871	absent cerebellum vermis lobule IX	missing triangular elevation on the vermis of the cerebellum
MP:0000872	abnormal cerebellum external granule cell layer morphology	any structural anomaly of the transient layer of the cerebellar cortex present during development which is composed of the dividing and migrating granule cells
MP:0000873	thin external granule cell layer	reduced thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells
MP:0000874	irregular external granule cell layer thickness	uneven thickness of the transient layer of the cerebellar cortex present during development which is composed of dividing and migrating granule cells
MP:0000875	abnormal cerebellar Purkinje cell layer	any structural anomaly of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells
MP:0000876	Purkinje cell degeneration	a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex
MP:0000877	abnormal Purkinje cell morphology	any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells
MP:0000878	abnormal Purkinje cell number	different from average number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex
MP:0000879	increased Purkinje cell number	greater than normal number of neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex
MP:0000880	decreased Purkinje cell number	fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex
MP:0000881	obsolete Abnormal Purkinje Cell Size	OBSOLETE.
MP:0000882	obsolete Increased Purkinje Cell Size dup.	OBSOLETE.
MP:0000883	obsolete Decreased Purkinje Cell Size dup.	OBSOLETE.
MP:0000884	delaminated Purkinje cell layer	splitting or disorganization of the layer of large neuron cell bodies between the molecular and granular layers of the cerebellum
MP:0000885	ectopic Purkinje cell	Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum
MP:0000886	abnormal cerebellar granule layer morphology	any structural anomaly of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border
MP:0000887	delaminated cerebellar granule layer	splitting or disorganization of the deepest of the three layers of the cerebellum that contains granule cells
MP:0000888	absent cerebellar granule layer	absence of the innermost cortical layer of the cerebellum; contains densely packed small neurons, mostly granule cells with some Golgi cells are found at the outer border
MP:0000889	abnormal cerebellar molecular layer	any structural anomaly of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells
MP:0000890	thin cerebellar molecular layer	reduced width of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells
MP:0000891	obsolete Abnormal Thickness of Molecular Layer	OBSOLETE.
MP:0000892	obsolete Increased Thickness of Molecular Layer	OBSOLETE.
MP:0000893	obsolete Decreased Thickness of Molecular Layer	OBSOLETE.
MP:0000894	obsolete Abnormal Cell Number of Molecular Layer	OBSOLETE.
MP:0000895	obsolete Increased Cell Number of Molecular Layer	OBSOLETE.
MP:0000896	obsolete Decreased Cell Number of Molecular Layer	OBSOLETE.
MP:0000897	abnormal midbrain morphology	any structural anomaly associated with the brain region derived from the middle of the three cerebral vesicles of the embryo; this region controls sensory and motor functions in the adult, including eye movement and coordination of auditory and visual reflexes
MP:0000898	midbrain hyperplasia	increase in the number of normal cells in normal arrangement in the brain region derived from the middle of the three cerebral vesicles of the embryo, typically resulting in increased size
MP:0000899	abnormal corpora quadrigemina morphology	any structural anomaly of the inferior and superior colliculus
MP:0000900	decreased colliculi size	smaller inferior and superior colliculus
MP:0000901	abnormal position of colliculi	positional abnormality of the inferior and superior colliculus
MP:0000904	abnormal superior colliculus morphology	any structural anomaly of the paired superior eminence of the mesencephalic tectum that is involved in auditory processing
MP:0000905	increased superior colliculus size	enlargement of the paired superior eminence of the mesencephalic tectum
MP:0000906	abnormal trigeminal V mesencephalic nucleus morphology	any structural anomaly of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve
MP:0000907	small mesencephalic trigeminal nucleus	reduced size of the group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve
MP:0000908	absent mesencephalic trigeminal nucleus	missing group of sensory neurons residing in a long, narrow plate in the midbrain; axons pass with the trigeminal nerve
MP:0000909	abnormal facial motor nucleus morphology	any structural anomaly of the group of motor neurons residing in the pons that innervate the muscles of facial expression
MP:0000910	small facial motor nucleus	reduced size of the group of motor neurons residing in the pons that innervate the muscles of facial expression
MP:0000911	abnormal trigeminal motor nucleus morphology	any structural anomaly of the group of motor neurons innervating the muscles of mastication
MP:0000912	small trigeminal motor nucleus	reduced size of the group of motor neurons innervating the muscles of mastication
MP:0000913	abnormal brain development	aberrant or incomplete differentiation of the brain
MP:0000914	exencephaly	neurocranial defects resulting in exposure or extrusion of the brain
MP:0000917	obstructive hydrocephaly	hydrocephaly due to a block in cerebrospinal fluid flow in the ventricular system
MP:0000919	cranioschisis	incomplete closure of the skull, usually congenital
MP:0000920	abnormal myelination	any anomaly in the process by which myelin sheaths are formed and maintained around neurons; oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane
MP:0000921	demyelination	abnormal degeneration or destruction of the myelin sheath that results in the partial absence or patchy, incomplete area of a myelin sheath over all or part of an axon or fiber tract
MP:0000923	abnormal roof plate morphology	any structural anomaly of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline
MP:0000924	absent roof plate	absence of the single row of specialized glial cells that occupies the dorsal midline of the developing neural tube along the entire anterior-posterior axis; the roof plate serves as a critical embryonic signaling center for the organization of dorsal neuronal cell types, and acts as a barrier preventing axons and cells migrating across the dorsal midline
MP:0000925	abnormal floor plate morphology	any structural anomaly of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube
MP:0000926	absent floor plate	absence of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube
MP:0000927	small floor plate	reduced size of the specialized glial structure (non-neuronal cells) situated at the ventral midline of the embryonic neural tube; this structure spans the anteroposterior axis from the midbrain to the tail regions, separating the left and right basal plates of the developing neural tube, and serves as an organizer to ventralize tissues in the embryo as well as to guide neuronal positioning and differentiation along the dorsoventral axis of the neural tube
MP:0000928	incomplete rostral neuropore closure	arrest of the fusion of the cephalic neural folds
MP:0000929	open neural tube	failure of completion of the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline
MP:0000930	wavy neural tube	undulations in the embryonic neural tube
MP:0000932	absent notochord	missing axial fibrocellular cord in embryos around which develops the vertebral primordia
MP:0000933	abnormal rhombomere morphology	any structural anomaly of any of the transiently divided segments of the developing neural tube of vertebrate embryos found within the hindbrain region in the area that will eventually become the rhombencephalon; the rhombomeres appear as a series of slightly constricted swellings in the neural tube, caudal to the cephalic flexure
MP:0000934	abnormal telencephalon development	anomaly in the progression of the enlarged anteriolateral part of the brain; consists of the paired cerebral hemispheres and olfactory bulbs, the basal ganglia and the connecting structures, and is considered to be the seat of conscious mental processes; it develops from the anterior-most embryological division of the brain that develops from the prosencephalon
MP:0000935	abnormal folding of telencephalic vesicles	malformation of the stereotypic invaginations forming the paired diverticula of the telencephalon
MP:0000936	small embryonic telencephalon	reduced size of the paired diverticula of the embryonic telencephalon, from which the forebrain develops
MP:0000937	abnormal motor neuron morphology	any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses
MP:0000938	motor neuron degeneration	retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses
MP:0000939	decreased motor neuron number	fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses
MP:0000940	abnormal motor neuron innervation pattern	any changes in the placement, morphology or number of motor nerve fibers to an effector motor tissue, or failure of refinement of neuronal connections during development
MP:0000941	obsolete failure of motor neuron target finding	OBSOLETE. failure of an innervating motor neuron to stop at target site and form terminal arbors
MP:0000942	obsolete excessive motor neuron axon growth	OBSOLETE. innervating motor neuron projections grow past typical endplate target and extend to myotendenous ends of muscle
MP:0000944	obsolete Reduced Olfactory mitral Cells	OBSOLETE.
MP:0000947	convulsive seizures	seizures characterized by uncontrolled motor activity
MP:0000948	nonconvulsive seizures	seizures without uncontrolled motor activity, but with impairment of consciousness
MP:0000950	abnormal seizure response to pharmacological agent	anomaly in the seizure activity response that is brought about by treatment with pharmacological agents
MP:0000951	sporadic seizures	occasional seizures occurring at irregular intervals
MP:0000952	abnormal CNS glial cell morphology	any structural anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons
MP:0000953	abnormal oligodendrocyte morphology	any structural anomaly of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS
MP:0000954	decreased oligodendrocyte progenitor number	fewer cells that differentiate into a type of glial cell in the central nervous system
MP:0000955	abnormal spinal cord morphology	any structural anomaly of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris
MP:0000956	decreased spinal cord size	smaller appearance of the spinal cord
MP:0000958	peripheral nervous system degeneration	a retrogressive impairment of function or destruction of the ganglia and peripheral nerves that lie outside the brain and spinal cord
MP:0000959	abnormal somatic sensory system morphology	any structural anomaly of the neural tissue involved in the transmission of sensory signals
MP:0000960	abnormal sensory ganglion morphology	any structural anomaly of the clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons, interneurons and non-neuronal supporting cells
MP:0000961	abnormal dorsal root ganglion morphology	any structural anomaly of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column
MP:0000962	disorganized dorsal root ganglion	loss of segmentation pattern of dorsal root ganglia or loss of regular spacing between the ganglia
MP:0000963	fused dorsal root ganglion	loss of DRG spacing pattern and the appearance of two or more ganglia as one
MP:0000964	small dorsal root ganglion	reduced size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column
MP:0000965	abnormal sensory neuron morphology	any structural anomaly of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses
MP:0000966	decreased sensory neuron number	fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses
MP:0000968	abnormal sensory neuron innervation pattern	any changes in the placement, morphology or number of sensory nerve fibers to sensory termini or to spinal cord
MP:0000969	abnormal nociceptor morphology	any structural anomaly of any of the peripheral receptors for pain, including receptors sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli
MP:0000970	abnormal polymodal receptor morphology	anomaly in a sensory receptor that may be stimulated by mechanical, thermal or chemical means
MP:0000971	abnormal thermoreceptor morphology	any structural anomaly of any of the cellular receptors that mediate the sense of temperature; in vertebrates, these are most often located under the skin
MP:0000972	abnormal mechanoreceptor morphology	anomaly in the receptors of the body, usually nerve termini, that respond to mechanical pressure or distortion
MP:0000973	abnormal cutaneous/subcutaneous mechanoreceptor morphology	any structural anomaly of the neuronal receptors that respond to mechanical pressure or distortion in the skin
MP:0000974	abnormal hair guard neuron morphology	anomaly of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals
MP:0000975	absent hair guard neurons	absence of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals
MP:0000976	hyperinnervation of hair guard cells	more robust innervation of the subcutaneous mechanoreceptors that innervate hair follicles of guard hairs, and are involved in the amplification of slow-moving and/or light touch stimuli signals
MP:0000977	abnormal hair-tylotrich neuron morphology	anomaly of the subcutaneous mechanoreceptors that innervate tylotrich hair follicles
MP:0000978	hyperinnervation of hair-tylotrich cells	more robust innervation of the hair tylotrich cells
MP:0000979	abnormal hair-down neuron morphology	anomaly of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli
MP:0000980	absent hair-down neurons	absence of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli
MP:0000981	hyperinnervation of hair-down cells	more robust innervation of the subcutaneous mechanosensitive D-hair (down-hair) neurons, which innervate hair follicles, and are characterized by a large-amplitude Cav3.2 T-current involved in the amplification of slow-moving and/or light touch stimuli
MP:0000982	abnormal Meissner's corpuscle morphology	any structural anomaly of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects
MP:0000983	enlarged Meissner's corpuscles	larger than average size of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects
MP:0000984	hyperinnervation of Meissner's corpuscle	more robust supply of nerve fibers connected to any part of any of the numerous oval bodies found in the dermal papillae of glabrous skin that transmit information about skin motion and slipping objects
MP:0000985	abnormal Merkel's receptor morphology	any structural anomaly of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute
MP:0000986	increased Merkel's receptor number	greater than the normal number of the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute
MP:0000987	hyperinnervation of Merkel's receptor	more robust supply of nerve fibers connected to the modified epidermal cells located in the stratum basale and found mostly in areas where sensory perception is acute
MP:0000988	abnormal pacinian corpuscle morphology	any structural anomaly of any of the rapidly adapting mechanoreceptors found in subcutaneous tissue beneath both hairy and glabrous skin, and which normally contain an afferent nerve fiber surrounded by a capsule with multiple concentric layers; trasmit signals generated by vibrations when grasping an object
MP:0000989	abnormal Ruffini's corpuscle morphology	any structural anomaly in the sensory cells in the subcutaneous tissue of the digits specialized to transduce mechanical stimuli, skin stretch, direction of object motion, hand shape and finger position
MP:0000990	abnormal skeletal muscle mechanoreceptor morphology	any structural anomaly of the receptors that respond to mechanical pressure or distortion in the skeletal muscle
MP:0000991	abnormal primary muscle spindle morphology	any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and sensitive to stretch velocity
MP:0000992	absent primary muscle spindle	missing sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity
MP:0000993	partial loss of primary muscle spindle	missing a portion of the sensory organ in muscle; involved in the stretch reflex and is sensitive to stretch velocity
MP:0000994	abnormal secondary muscle spindle morphology	any structural anomaly of the sensory organ in muscle; involved in the stretch reflex and not sensitive to stretch velocity
MP:0000995	absent secondary muscle spindle	lack of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity
MP:0000996	partial loss of secondary muscle spindle	missing a portion of the sensory organ in muscle; involved in the stretch reflex and is not sensitive to stretch velocity
MP:0000997	abnormal synovial joint capsule morphology	any structural anomaly of the sac or its contents that encloses the articulating ends of bones participating in a synovial joint
MP:0000998	absent synovial joint capsule	missing the sac that encloses the articulating ends of bones participating in a synovial joint
MP:0000999	abnormal golgi tendon organ morphology	any structural anomaly of the sensory organ in muscle that is involved in regulating muscle tension
MP:0001000	absent golgi tendon organ	missing sensory organ in muscle that is involved in regulating muscle tension
MP:0001001	abnormal chemoreceptor morphology	any structural anomaly of any of the cells specialized to detect chemical substances and relay that information centrally in the nervous system
MP:0001002	obsolete abnormal taste bud morphology	OBSOLETE. any structural anomaly of the small sensory organs located in the tongue that contain gustatory receptor cells, basal cells, and supporting cells
MP:0001003	abnormal olfactory receptor morphology	any structural anomaly of the proteins, usually projecting from the cilia of olfactory receptor neurons, that specifically bind odorant molecules and trigger responses in the specialized neurons of the olfactory epithelium
MP:0001004	abnormal retina photoreceptor morphology	any structural anomaly of a cell specialized to detect and transduce light, including rods and cones of the retina
MP:0001005	abnormal retina rod cell morphology	any structural anomaly of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane; rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision
MP:0001006	abnormal retina cone cell morphology	any structural anomaly of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment; cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision
MP:0001007	abnormal sympathetic system morphology	any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations
MP:0001008	abnormal sympathetic ganglion morphology	any structural anomaly of the ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia, which include the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia
MP:0001009	paravertebral ganglia hyperplasia	increase in the number of normal cells in normal arrangement in the paravertebral ganglia, typically resulting in increased size
MP:0001010	prevertebral ganglia hyperplasia	increase in the number of normal cells in normal arrangement in the prevertebral ganglia, typically resulting in increased size
MP:0001011	abnormal superior cervical ganglion morphology	any structural anomaly of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck
MP:0001012	superior cervical ganglion hypertrophy	increase in the size of cells in the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck
MP:0001013	enlarged superior cervical ganglion	increased size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck
MP:0001014	absent superior cervical ganglion	lack of the group of neurons that is the largest of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck
MP:0001015	small superior cervical ganglion	reduced size of the group of neurons that is the largest of the ganglia of the sympathetic trunk; normally lies at the base of the skull and innervates the head and neck
MP:0001016	abnormal middle cervical ganglion morphology	any structural anomaly of the small ganglion located at the level of the cricoid cartilage of the laryngeal wall
MP:0001017	abnormal stellate ganglion morphology	any structural anomaly of the group of neurons formed by the fusion of the inferior cervical and first thoracic ganglia
MP:0001018	obsolete abnormal adrenal gland ganglion	OBSOLETE.
MP:0001019	abnormal L4 dorsal root ganglion morphology	any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fourth lumbar vertebra
MP:0001020	L4 dorsal root ganglion hypertrophy	increased bulk size of the L4 spinal ganglion
MP:0001021	small L4 dorsal root ganglion	reduced size of the L4 spinal ganglion
MP:0001022	abnormal L5 dorsal root ganglion morphology	any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the fifth lumbar vertebra
MP:0001023	L5 dorsal root ganglion hypertrophy	increased bulk size of L5 spinal ganglion
MP:0001024	small L5 dorsal root ganglion	reduced size of the L5 spinal ganglion
MP:0001025	abnormal sympathetic neuron morphology	any structural anomaly of any of the neurons of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations
MP:0001026	abnormal adrenergic neuron morphology	any structural anomaly of the neurons which secrete norepinephrine as a neurotransmitter; adrenergic neurons are mostly sympathetic postganglionic nerves plus some within specific brainstem foci
MP:0001027	obsolete abnormal adrenergic innervation	OBSOLETE.
MP:0001028	obsolete adrenergic hyperinnervation of muscle	OBSOLETE.
MP:0001031	obsolete cholinergic hyperinnervation of muscle	OBSOLETE.
MP:0001032	abnormal peptidergic neuron morphology	any structural anomaly of the nerve fibers that release small peptides as their neurotransmitter
MP:0001033	abnormal parasympathetic system morphology	any structural anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system
MP:0001034	abnormal parasympathetic ganglion morphology	any structural anomaly of the ganglia of the parasympathetic nervous system, including the ciliary, pterygopalatine, submandibular, and otic ganglia in the cranial region and intrinsic (terminal) ganglia associated with target organs in the thorax and abdomen
MP:0001035	abnormal submandibular ganglion morphology	any structural anomaly of the ganglion associated with the lingual nerve that provides postsynaptic fibers to the submandibular and sublingual glands
MP:0001036	small submandibular ganglion	reduced size of the small parasympathetic ganglion of the lingual nerve
MP:0001037	abnormal parasympathetic neuron morphology	any structural anomaly of the neurons of the autonomic nervous system that are responsible for innervation of smooth muscle, cardiac muscle and glands
MP:0001038	abnormal cholinergic neuron morphology	any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter, including include alpha-motor neurons of the spinal cord, cranial nerves innervating skeletal muscle, preganglionic sympathetic and postganglionic parasympathetic neurons
MP:0001039	obsolete abnormal cholinergic innervation	OBSOLETE. malformation or absence of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter
MP:0001040	deficient enteric cholinergic innervation	defective or incomplete supply of nerve fibers to the intestinal system that utilize acetylcholine as a neurotransmitter
MP:0001041	obsolete absent lacrimal gland cholinergic innervation	OBSOLETE. missing supply of nerve fibers to the gland that secretes tears
MP:0001042	obsolete absent sublingual salivary gland cholinergic innervation	OBSOLETE. missing supply of nerve fibers to the exocrine gland on the floor of the mouth that secretes saliva
MP:0001043	obsolete absent parotid salivary gland cholinergic innervation	OBSOLETE. missing supply of nerve fibers to the exocrine gland lateral to the jaw that secretes saliva
MP:0001044	abnormal enteric nervous system morphology	any structural anomaly of the part of the autonomic nervous system that innervates the gastrointestinal tract, the pancreas, and the gallbladder and can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport
MP:0001045	abnormal enteric ganglia morphology	any structural anomaly or deformity of the groups of nerve cell bodies associated with the enteric neurons
MP:0001046	abnormal enteric neuron morphology	any structural anomaly of the neurons that innervate the esophagus, stomach, small and large bowel
MP:0001047	abnormal enteric cholinergic neuron morphology	any structural anomaly of the neurons that utilize acetylcholine as a neurotransmitter and innervate the esophagus, stomach, small and large bowel
MP:0001048	absent enteric neurons	absence of the neurons that innervate the esophagus, stomach, small and large bowel
MP:0001049	abnormal enteric cholinergic innervation	any structural anomaly of the supply of nerve fibers that utilize acetylcholine as a neurotransmitter to the intestinal system
MP:0001051	abnormal somatic motor system morphology	any structural anomaly of the neural tissue involved in the transmission of motor signals
MP:0001052	abnormal innervation pattern to muscle	any changes in the placement, morphology or number of sensory, sympathetic or motor nerves to targets in muscle
MP:0001053	abnormal neuromuscular synapse morphology	any structural anomaly of the membrane to membrane contact of a motor axon and a muscle myofiber that is responsible for the transmission of nerve impulses
MP:0001054	failure of neuromuscular synapse presynaptic differentiation	inability of nerve terminals to find target and/or form terminal arbors for synaptic transmission at the neuromuscular synapse
MP:0001055	failure of neuromuscular synapse postsynaptic differentiation	inability of an effector cell to form a differentiated postsynaptic membrane in response to innervation at the neuromuscular synapse
MP:0001056	abnormal cranial nerve morphology	any structural anomaly of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves
MP:0001059	optic nerve atrophy	acquired diminution of the size of the optic nerve, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0001061	abnormal oculomotor nerve morphology	any structural anomaly of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye; and also sends parasympathetic efferents to the muscles controlling pupillary constriction and accommodation
MP:0001062	absent oculomotor nerve	absence of the third cranial nerve, which normally sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye
MP:0001063	abnormal trochlear nerve morphology	any structural anomaly of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye
MP:0001064	absent trochlear nerve	absence of the fourth cranial nerve, which normally carries the motor innervation of the superior oblique muscles of the eye
MP:0001065	abnormal trigeminal nerve morphology	any structural anomaly of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular
MP:0001066	absent trigeminal nerve	lack of the chief sensory nerve of the face and motor nerve of the muscles of mastication; has three major divisions: ophthalmic, maxillary and mandibular
MP:0001067	absent mandibular nerve	missing third division of the trigeminal nerve
MP:0001068	abnormal mandibular nerve branching	malformed or misprojected axons of the mandibular nerve
MP:0001069	obsolete absent trigeminal nerve connections to hindbrain	OBSOLETE. missing axonal connection from the trigeminal ganglion to the pons and medulla oblongata
MP:0001070	abnormal abducens nerve morphology	any structural anomaly of the sixth cranial nerve, which originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye
MP:0001071	abnormal facial nerve morphology	any structural anomaly of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue; principal branches are the superficial opthalmic, buccal, palatine and hyomandibular
MP:0001072	abnormal vestibulocochlear nerve morphology	any structural anomaly in the composite sensory nerve innervating the receptor cells of the membranous labyrinth; it consists of two major, anatomically and functionally distinct components, each of which have different central connections: the vestibular nerve and the cochlear nerve
MP:0001073	abnormal glossopharyngeal nerve morphology	any structural anomaly of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion
MP:0001074	abnormal vagus nerve morphology	any structural anomaly of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis
MP:0001075	abnormal accessory nerve morphology	any structural anomaly of the eleventh cranial nerve, which normally originates from neurons in the medulla and in the cervical spinal cord
MP:0001076	abnormal hypoglossal nerve morphology	any structural anomaly of the motor nerve which innervates all the intrinsic and all but one of the extrinsic muscles of the tongue
MP:0001077	abnormal spinal nerve morphology	any structural anomaly of the any of the 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment
MP:0001078	abnormal phrenic nerve morphology	any structural anomaly of motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues
MP:0001079	absent phrenic nerve	absence of the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues
MP:0001080	defasiculated phrenic nerve	misprojection or failure to bundle the motor, sensory and sympathetic neuron axons that project to the diaphragm and other tissues
MP:0001081	abnormal cranial ganglia morphology	any structural anomaly of the groups of nerve cell bodies associated with the twelve cranial nerves
MP:0001082	abnormal geniculate ganglion morphology	any structural anomaly of the group of sensory neuron cell bodies associated with the facial nerve (seventh cranial nerve)
MP:0001083	small geniculate ganglion	reduced size of the geniculate ganglion or decreased size of sensory neuron cell bodies associated with the facial nerve
MP:0001084	abnormal petrosal ganglion morphology	any structural anomaly of the larger, lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve
MP:0001085	small petrosal ganglion	reduced size of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve
MP:0001086	absent petrosal ganglion	absence of the lower group of sensory neuron cell bodies associated with the glossopharyngeal nerve
MP:0001087	abnormal nodose ganglion morphology	any structural anomaly of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)
MP:0001088	small nodose ganglion	reduced size of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)
MP:0001089	absent nodose ganglion	absence of the large group of sensory neuron cell bodies, anterior to the jugular vein, associated with the vagus nerve (tenth cranial nerve)
MP:0001091	obsolete small vestibular cochlear ganglion	OBSOLETE.
MP:0001092	abnormal trigeminal ganglion morphology	any structural anomaly of the group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)
MP:0001093	small trigeminal ganglion	reduced size of the trigeminal ganglion
MP:0001094	trigeminal ganglion hypertrophy	increased bulk size due to increased cell size of the trigeminal ganglion
MP:0001095	enlarged trigeminal ganglion	increased size of the group of sensory neuron cell bodies associated with the trigeminal nerve
MP:0001096	abnormal glossopharyngeal ganglion morphology	any structural anomaly of the two groups of sensory neuron cell bodies associated with the ninth cranial nerve
MP:0001097	abnormal superior glossopharyngeal ganglion morphology	any structural anomaly of the upper, smaller ganglion of the glossopharyngeal nerve located at the jugular foramen
MP:0001098	small superior glossopharyngeal ganglion	reduced size of the upper ganglion of the glossopharyngeal nerve located at the jugular foramen
MP:0001100	abnormal vagus ganglion morphology	any structural anomaly of the group of sensory neuron cell bodies associated with the vagus nerve
MP:0001101	abnormal superior vagus ganglion morphology	any structural anomaly of the upper ganglion of the vagus nerve located at the jugular foramen
MP:0001102	small superior vagus ganglion	reduced size of the upper ganglion of the vagus nerve located at the jugular foramen
MP:0001105	abnormal PNS glial cell morphology	any structural anomaly of non-neuronal cells that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons
MP:0001106	abnormal Schwann cell morphology	any structural anomaly of the cells which form the insulating myelin sheaths of peripheral axons
MP:0001107	decreased Schwann cell number	fewer than normal number of cells that sheath the axons of the peripheral nervous system
MP:0001108	absent Schwann cells	missing cells that sheath the axons of the peripheral nervous system
MP:0001109	absent Schwann cell precursors	missing progenitors of cells that sheath the axons of the peripheral nervous system
MP:0001116	small gonad	reduced size of the testis or the ovary
MP:0001117	absent gametes	absence of mature reproductive cells, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex to give a zygote
MP:0001119	abnormal female reproductive system morphology	any structural anomaly of the organs associated with producing offspring in the gender that bears the offspring
MP:0001120	abnormal uterus morphology	any structural anomaly of the female muscular organ of gestation in which the developing embryo or fetus is nourished until birth
MP:0001121	uterus hypoplasia	decrease in the number of normal cells in normal arrangement in the uterus, typically resulting in decreased size
MP:0001123	dilated uterus	stretched or widened luminal space of the female muscular organ of gestation
MP:0001124	abnormal gametes	anomaly of any mature reproductive cell, ovum or spermatozoon, capable of fusing with a cell of similar origin, but opposite sex, to produce a zygote
MP:0001125	abnormal oocyte morphology	any structural anomaly of the mature germ cells in the female
MP:0001126	abnormal ovary morphology	any structural anomaly of the female reproductive gland containing the germ cells
MP:0001127	small ovary	reduced size of the female reproductive gland containing the germ cells
MP:0001128	ovary hyperplasia	increase in the number of normal cells in normal arrangement in the ovary, typically resulting in increased size
MP:0001129	impaired ovarian folliculogenesis	a block in the formation of the spherical ovum in the ovary
MP:0001130	abnormal ovarian folliculogenesis	atypical formation or failure to form the spherical ovum in the ovary
MP:0001131	abnormal ovarian follicle morphology	any structural anomaly of the sac-like structure in the ovary which surrounds an ovum
MP:0001132	absent mature ovarian follicles	absence of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle
MP:0001133	impaired luteal cell differentiation	abnormal development of the cells of the corpus luteum of the ovary
MP:0001134	absent corpus luteum	absence of the yellow endocrine body formed in the ovary after follicle rupture
MP:0001135	abnormal uterine cervix morphology	any structural anomaly of the lower opening of the uterus to the vagina
MP:0001136	dilated uterine cervix	stretched or widened aperture of the lower opening of the uterus to the vagina
MP:0001137	abnormal uterine cervix epithelium morphology	any structural anomaly of the epithelial layer of the cervix
MP:0001138	abnormal uterine cervix squamous epithelium morphology	any structural anomaly of the scaly epithelial layer of the cervix
MP:0001139	abnormal vagina morphology	any structural anomaly of the part of the genital canal in the female that extends between the cervix of the uterus and the vestibule; it is an organ of copulation that receives the penis during sexual intercourse
MP:0001140	abnormal vagina epithelium morphology	any structural anomaly of the epithelial layer of the vagina
MP:0001141	thickened vaginal epithelium	increased depth of the vaginal epithelial layer
MP:0001142	abnormal vagina orifice morphology	any structural anomaly of the median slit located inferior and posterior to the external urethral orifice in the female; the exit for menstrual flow and birth and the entrance for the penis during sexual intercourse; the size and appearance of the vaginal orifice varies inversely with that of the hymen (G. membrane), a thin fold of mucous membrane that surrounds the vaginal orifice
MP:0001143	constricted vagina orifice	shrunken, narrowed external median slit located inferior and posterior to the external urethral orifice in the female
MP:0001144	vagina atresia	imperforation or occlusion of the vagina, or adhesion of the walls of the vagina
MP:0001145	abnormal male reproductive system morphology	any structural anomaly of the organs associated with producing offspring in the gender that produces spermatozoa
MP:0001146	abnormal testis morphology	any structural anomaly of the male reproductive glands
MP:0001147	small testis	reduced size of the male reproductive glands
MP:0001148	enlarged testis	increased size of the male reproductive glands
MP:0001149	testicular hyperplasia	increase in the number of normal cells in normal arrangement in the testes, typically resulting in increased size
MP:0001150	enlarged scrotum	increased size of the external sac of skin that encloses the testes
MP:0001151	enlarged foreskin	increased size of the loose fold of skin that covers the penis
MP:0001152	increased Leydig cell number	increased number of the interstitial cells found adjacent to the seminiferous tubules in the testicle that produce testosterone in the presence of luteinizing hormone
MP:0001153	small seminiferous tubules	reduced diameter of the tubules in the testes where spermatogenesis occurs
MP:0001154	seminiferous tubule degeneration	a retrogressive impairment of function or destruction of the tubules in the testes where spermatogenesis occurs
MP:0001155	arrest of spermatogenesis	block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa
MP:0001156	abnormal spermatogenesis	incomplete maturation or aberrant formation of the male gametes
MP:0001157	small seminal vesicle	reduced size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0001158	abnormal prostate gland morphology	any structural anomaly of the gland in males that secretes part of the seminiferous fluid
MP:0001159	absent prostate gland	missing gland in males that secretes part of the seminiferous fluid
MP:0001163	abnormal prostate gland anterior lobe morphology	any structural anomaly of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles
MP:0001167	prostate gland epithelial hyperplasia	epithelium is multi-layered instead of columnar and has increased cell number
MP:0001168	abnormal prostate gland epithelium morphology	any structural anomaly of the prostate epithelium
MP:0001169	abnormal bulbourethral gland morphology	any structural anomaly of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female
MP:0001170	bulbourethral gland hyperplasia	increase in the number of normal cells in normal arrangement in the bulbourethral gland, typically resulting in increased size
MP:0001173	obsolete decreased number of ductal cells of the bulbourethral gland	OBSOLETE. fewer than the normal number of cells found in the ducts through which the bulbourethral glands discharge mucus into the spongy part of the urethra
MP:0001175	abnormal lung morphology	any structural anomaly of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs
MP:0001176	abnormal lung development	anomaly in the process of formation of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs
MP:0001177	atelectasis	decrease or absent air in the entire or part of a lung, with resulting loss of lung volume, due to trauma, blockage or congenital defect
MP:0001178	pulmonary hypoplasia	decrease in the number of normal cells in normal arrangement in the lung, typically resulting in decreased size
MP:0001179	thick pulmonary interalveolar septum	increased width of the tissue intervening between two adjacent pulmonary alveoli, which consists of the basement membranes of alveolar-lining epithelium (mostly type I pneumocytes) and capillary endothelium
MP:0001180	obsolete cellular infiltration of airway walls	OBSOLETE.
MP:0001181	absent lungs	absence of the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs
MP:0001182	lung hemorrhage	bleeding within the paired lobed visceral organs of respiration in the pulmonary cavity of the thorax where aeration of the blood normally occurs
MP:0001183	overexpanded pulmonary alveolus	expanded volume of one or more of the saclike terminal dilations of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries
MP:0001184	absent pulmonary alveoli	absence of the saclike terminal dilation of the respiratory bronchioles, alveolar ducts and alveolar sacs across which gas exchance occurs between alveolar air and the pulmonary capillaries
MP:0001186	pigmentation phenotype	the observable morphological and physiological characteristics of mammalian organisms that are manifested through the deposition or aggregation of coloring matter in any tissue or cell of the organism
MP:0001188	hyperpigmentation	excess of pigment in any or all tissues or a part of a tissue
MP:0001189	absent skin pigmentation	lack of pigmentation of the skin
MP:0001190	reddish skin	skin has a more intense ruddy appearance than normal, often due to capillary congestion
MP:0001191	abnormal skin condition	any anomaly in the state or quality of the skin
MP:0001192	scaly skin	loss of the outer layer of the epidermis in thick, dry scale-like patches
MP:0001193	psoriasis	chronic skin lesions characterized by inflammation and silvery-scaly patches
MP:0001194	dermatitis	inflammation of the skin (redness and itching) caused by an allergic reaction or contact with an irritant
MP:0001195	flaky skin	shedding flakes on the skin
MP:0001196	shiny skin	skin with a glossy or glistening appearance
MP:0001197	oily skin	skin secreting an unusually high amount of oil, resulting in a glossy, shiny appearance
MP:0001198	tight skin	skin has a taut, stretched appearance
MP:0001199	thin skin	reduced thickness of the outer protective layer of the body
MP:0001200	thick skin	greater thickness of the outer protective layer of the body
MP:0001201	translucent skin	skin that is more transparent to light than normal
MP:0001202	skin photosensitivity	abnormally heightened reactivity of the skin to sunlight
MP:0001203	increased sensitivity to skin irradiation	increased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage
MP:0001204	decreased sensitivity to skin irradiation	decreased incidence of aberrant or damaged cells due to irradiation induced genotoxic damage
MP:0001208	blistering	accumulation of fluid- filled thin walled structures under the epidermis or within the epidermis
MP:0001209	spontaneous skin ulceration	unpredictable appearance of skin lesions, usually with inflammation
MP:0001210	skin ridges	long raised strips of skin, usually aligned to the proximal-distal axis
MP:0001211	wrinkled skin	irregular folds and/or indentations on the skin
MP:0001212	skin lesions	focal pathological and/or inflammatory changes characterized by alteration in the size, shape and organization of the cellular components of the skin
MP:0001213	abnormal skin cell number	greater than or fewer than the expected numbers of cells in the cutis
MP:0001214	skin hyperplasia	increase in the number of normal cells in normal arrangement in the skin, typically resulting in increased thickness
MP:0001215	skin hypoplasia	decrease in the number of normal cells in normal arrangement in the skin, typically resulting in decreased size
MP:0001216	abnormal epidermal layer morphology	any structural anomaly of the superficial epithelial portion of the skin
MP:0001217	absent epidermis	missing the epidermal cell layer in the skin
MP:0001218	thin epidermis	reduced thickness of the superficial epithelial portion of the skin
MP:0001219	thick epidermis	increase in the width of the epidermal cell layer in the skin
MP:0001220	epidermal necrosis	morphological changes resulting from pathological death of the epidermal layer of skin; usually due to irreversible damage
MP:0001221	epidermal atrophy	acquired diminution of the size of epidermal layer of the skin, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0001222	epidermal hyperplasia	increase in the number of normal cells in normal arrangement in the epidermis, typically resulting in increased thickness
MP:0001224	abnormal keratinocyte apoptosis	aberrant programmed cell death or anomaly in the number of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
MP:0001230	epidermal desquamation	shedding of the cuticle of the epidermis in scales or shreds
MP:0001231	abnormal epidermis stratum basale morphology	any structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells
MP:0001232	absent epidermis stratum basale	absence of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells
MP:0001233	abnormal epidermis suprabasal layer morphology	any structural anomaly of the suprabasal layer of the epidermis
MP:0001234	absent suprabasal layer	absence of the suprabasal layer of the skin
MP:0001235	disorganized suprabasal layer	derangement of the pattern of the suprabasal layer of the skin
MP:0001236	abnormal epidermis stratum spinosum morphology	any structural anomaly of the layer of polyhedral cells in the epidermis; shrinkage and adhesion of these cells gives a spiny or prickly appearance
MP:0001237	enlarged spinous cells	increased size of the immature keratinocytes of the spinous layer of the epidermis
MP:0001238	thin epidermis stratum spinosum	reduced thickness of the stratum spinosum; the polyhedral cell layer
MP:0001239	abnormal epidermis stratum granulosum morphology	any structural anomaly of the layer of flattened cells containing basophilic granules of keratohyalin and lying just above the stratum spinosum (spiny layer) of the epidermis
MP:0001240	abnormal epidermis stratum corneum morphology	any structural anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells
MP:0001241	absent epidermis stratum corneum	absence of the outer layer of the epidermis, composed of several layers of keratinized non-nucleated cells
MP:0001242	hyperkeratosis	thickening of the horny layer of the epidermis
MP:0001243	abnormal dermal layer morphology	any structural anomaly or atypical condition of the dermal layer of the skin
MP:0001244	thin dermal layer	reduced thickness of the dermis
MP:0001245	thick dermal layer	increased depth of the dermis
MP:0001246	mixed cellular infiltration to dermis	gradual accumulation of mixed cell types in the dermis that are not normally found there
MP:0001247	dermal cyst	presence of one or more abnormal membranous sacs in the dermis
MP:0001248	obsolete absent connective tissue	OBSOLETE. missing supporting framework of a tissue or the body; formed of fibrous or ground substance
MP:0001249	obsolete absent dermal adipose tissue	OBSOLETE. missing fat associated with the skin layers
MP:0001251	dermis papillary layer hypercellularity	increased cell density of the superficial layer
MP:0001253	abnormal body height	any anomaly in the shoulder to floor distance compared to controls
MP:0001254	increased body height	increased shoulder to floor distance compared to controls
MP:0001255	decreased body height	decreased shoulder to floor distance compared to controls
MP:0001256	abnormal body length	any anomaly in the measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction
MP:0001257	increased body length	increased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction
MP:0001258	decreased body length	decreased measure of the head and trunk (head, thorax and abdomen) in the rostral-caudal direction
MP:0001259	abnormal body weight	anomaly in average weight compared to controls
MP:0001260	increased body weight	greater than normal average weight
MP:0001261	obese	a status with body weight that is grossly above the average, acceptable or desirable weight, usually due to accumulation of excess fat tissue in the body
MP:0001262	decreased body weight	lower than normal average weight
MP:0001263	weight loss	progressive reduction of body weight below normal average for age
MP:0001264	increased body size	larger than average body weight, height and/or length of an organism compared to controls
MP:0001265	decreased body size	smaller than average body weight, height and/or length of an organism compared to controls
MP:0001267	enlarged chest	wider diameter, or distended chest cavity
MP:0001268	barrel chest	distended circumference of the thoracic and abdominal areas
MP:0001270	distended abdomen	abdomen appears curved outward or swollen
MP:0001272	increased metastatic potential	greater likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it
MP:0001273	decreased metastatic potential	reduced likelihood of a tumor cell spreading from the site of the initial tumor formation and forming a secondary tumor at another site not directly connected with it
MP:0001274	curly vibrissae	coiled or spiral shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001277	tangled vibrissae	snarled or intertwined stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001278	kinked vibrissae	sharp bends in the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001279	wavy vibrissae	undulations or a sinusoidal shape of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001280	loss of vibrissae	inability to retain the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001281	increased vibrissae length	longer average length of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001282	short vibrissae	decreased length of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors
MP:0001283	sparse vibrissae	few and widely spaced stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001284	absent vibrissae	absence of the stiff hairs that project from the face around the nose of most mammals, and which act as touch receptors
MP:0001286	abnormal eye development	malformation or arrest of differentiation of the visual organ
MP:0001288	abnormal lens induction	any anomaly in the signaling at short range between the head ectoderm and the optic vesicle that results in the head ectoderm forming a lens
MP:0001289	persistence of hyaloid vascular system	failure of the degeneration of the transient vascular system of the eye during development, that normally nourishes the retina, immature lens and primary vitreous of the developing eye
MP:0001290	delayed eyelid opening	late average time for the first postnatal eye opening
MP:0001292	abnormal lens vesicle development	malformation or abnormal patterning of the ectodermal invagination that forms opposite the optic cup in the primordium of the lens of the eye
MP:0001293	anophthalmia	absence of the globe and ocular tissue from the orbit, with or without the presence of ocular adnexa (eyelids, conjunctiva, and lacrimal apparatus); remnants of the globe sometimes appear in ectopic locations
MP:0001296	macrophthalmia	increased average size of the eyes
MP:0001297	microphthalmia	reduced average size of one or both eyes; generally refers to a congenital defect
MP:0001299	abnormal eye distance/ position	abnormal placement of the eyes in relation to each other or in relation to other craniofacial structures
MP:0001300	ocular hypertelorism	increased interpupillary distance, i.e. increased distance between the center of the pupils of the two eyes
MP:0001301	obsolete abnormal eye movement	OBSOLETE.
MP:0001302	eyelids open at birth	open eyes instead of closed at perinatal stage; failure of the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye to fuse completely together during development and an individual is born with the eye(s) uncovered leading to degrees of injury and blindness
MP:0001303	abnormal lens morphology	any structural anomaly of the transparent structure of the eye responsible for focusing light rays
MP:0001304	cataract	complete or partial opacity of the lens
MP:0001305	enlarged lens	increased size of the transparent structure of the eye responsible for focusing light rays
MP:0001306	small lens	reduced size of the transparent structure of the eye responsible for focusing light rays
MP:0001307	fused cornea and lens	condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye
MP:0001308	abnormal lens polarity	failure of normal orientation of the lens during development
MP:0001309	hydropic eye lens fibers	swollen cortical fibers of the eye lens
MP:0001310	abnormal conjunctiva morphology	any structural anomaly of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball
MP:0001312	abnormal cornea morphology	any structural anomaly of the transparent anterior portion of the fibrous coat of the eye that covers the iris, pupil, and anterior chamber; together with the lens, the cornea refracts light
MP:0001313	increased incidence of corneal inflammation	greater than average occurrence and/or persistence of the local accumulation of fluid, plasma proteins, and leukocytes in the cornea
MP:0001314	cornea opacity	complete or partial clouding of the cornea
MP:0001316	cornea scarring	appearance of fibrous tissue on the cornea after healing in response to injury
MP:0001317	abnormal pupil morphology	any structural anomaly of the central circular aperture of the iris through which light rays enter the eye
MP:0001318	pupil opacity	milky or cloudy appearance of the central circular aperture of the iris through which light rays normally enter the eye
MP:0001319	irregularly shaped pupil	shape defects in the aperture of the iris through which light rays enter the eye, usually circular
MP:0001320	small pupil	smaller than normal size of the central circular aperture of the iris through which light rays enter the eye
MP:0001322	abnormal iris morphology	any structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye
MP:0001323	obsolete iris opacity	OBSOLETE. milky or cloudy iris that is impervious to light
MP:0001324	abnormal eye pigmentation	change in the normal pigmentation of the eye to another color, or lack of color
MP:0001325	abnormal retina morphology	any structural anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors
MP:0001326	retina degeneration	retrogressive pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function
MP:0001327	decreased retina photoreceptor cell number	fewer than the expected number of rods and/or cones
MP:0001328	disorganized retina layers	derangement of the pattern of the sheets of cells comprising the optic part of the retina
MP:0001329	retina hyperplasia	increase in the number of normal cells in normal arrangement in the retina, typically resulting in increased size
MP:0001330	abnormal optic nerve morphology	any structural anomaly of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies
MP:0001332	abnormal optic nerve innervation	misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain
MP:0001333	absent optic nerve	absence of the second cranial nerve which is responsible for conveying visual information from the retina to the brain
MP:0001334	absent optic tract	absence of the band of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region
MP:0001335	obsolete Subject to Infection	OBSOLETE.
MP:0001336	obsolete increased incidence of inflamed eyes	OBSOLETE. greater than normal frequency of inflammatory response in the eyes
MP:0001337	dry eyes	absence of natural or normal moisture in the eye
MP:0001340	abnormal eyelid morphology	any structural anomaly of the skin folds covering the front of the eyeball
MP:0001341	absent eyelids	missing skin folds covering the front of the eyeball when closed
MP:0001343	pronounced eyelids	strongly protruding eyelids
MP:0001344	blepharoptosis	ptosis, drooping eyelids
MP:0001345	Meibomian gland atrophy	acquired diminution of the size of the sebaceous glands embedded in the tarsal plate of each eyelid, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0001346	abnormal lacrimal gland morphology	any structural anomaly of the glands that secrete tears
MP:0001347	absent lacrimal glands	missing the glands that secrete tears
MP:0001348	abnormal lacrimal gland physiology	any functional anomaly of the glands that secrete tears
MP:0001349	excessive tearing	an unusually high amount of fluid in the eye, either oversecreted by the lacrimal glands, or due to imperfect drainage by the tear conducting passages, often resulting in overflow of fluid from the eye onto the cheek
MP:0001353	increased aggression towards mice	when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward other mice
MP:0001354	increased aggression towards male mice	when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward male mice
MP:0001355	submission towards male mice	no domineering, assault posture nor hostile physical action toward male mice
MP:0001356	increased aggression towards female mice	when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward female mice
MP:0001357	increased aggression towards humans	when compared to controls, subjects exhibit greater than the normal level of domineering, assaultive posture and/or hostile physical action toward humans
MP:0001358	aggression towards inanimate objects	a domineering, assault posture and/or hostile physical action toward inanimate objects
MP:0001359	obsolete piling	OBSOLETE.
MP:0001360	abnormal social investigation	altered behavior of animals to approach and examine conspecifics
MP:0001361	social withdrawal	reclusive behavior; the tendency to refrain from participating in social situations and to seek isolation
MP:0001362	abnormal anxiety-related response	altered emotional response related to anticipation of a non-specific threat
MP:0001363	increased anxiety-related response	when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests
MP:0001364	decreased anxiety-related response	when compared to controls, subjects exhibit fewer responses thought to be indicative of anxiety in behavioral tests
MP:0001365	obsolete increased escape behavior induced by intruder mouse	OBSOLETE. resident animals exhibit escape behavior and do not initiate social investigation of an intruder mouse
MP:0001366	obsolete impaired stress response in porsolt forced swin test	OBSOLETE. reduced freezing behavior resulting from failed escape attempts induced by forced swim in a small cylinder
MP:0001373	obsolete Increased Fecundity	OBSOLETE.
MP:0001375	abnormal mating preference	any change from the common preference of an initiating organism to initiate sexual contact with a receptive partner; in rodents, this usually refers to males that attempts to initiate sexual behavior with males and females indiscriminately
MP:0001376	abnormal mating receptivity	deviation from the normal cycle or inability of females to respond favorably to males that initiate sexual behavior
MP:0001377	abnormal mating frequency	increased, reduced or absent attempt of sexual behavioral contact between an initiating organism and a receptive partner
MP:0001378	abnormal ejaculation	anomalies in the ability to propulse semen from the genital ducts and the urethra to the exterior
MP:0001379	abnormal penile erection	altered ability to achieve a rigid state of the penis obtained in the condition in which the erectile tissue is filled with blood
MP:0001380	reduced male mating frequency	males do not as frequently initiate sexual behavior (as scored by the presence of copulation plugs in rodents, not due to infertility)
MP:0001382	abnormal nursing	females show anomlies in the feeding of offspring from mammary glands, or do not nurse offspring, or nurse offspring infrequently
MP:0001384	abnormal pup retrieval	any anomaly in the ability of a nesting female to retrieve stray pups to the nest or a delay in retrieving stray pups
MP:0001385	pup cannibalization	the killing and eating of newborn mice by the mother; however, this can be a normal response if the mother does not recognize the pups as her own
MP:0001386	abnormal maternal nurturing	anomaly in the behaviors related to a female tending to young
MP:0001387	obsolete abnormal movement/ locomotion	OBSOLETE.
MP:0001388	abnormal stationary movement	altered ability or inability to change body posture or shift a body part
MP:0001389	abnormal eye movement	deviation from the normal motility of the visual organs
MP:0001391	abnormal tail movements	a change from the normal manner of moving the tail
MP:0001392	abnormal locomotor behavior	altered ability or inability to move from place to place in response to stimuli
MP:0001393	ataxia	inability to coordinate voluntary muscular movements
MP:0001394	circling	repeated movement in a circle; often associated with inner ear defects
MP:0001395	bidirectional circling	circling behavior exhibited in both clockwise and counterclockwise directions
MP:0001396	unidirectional circling	circling behavior in one direction only, either clockwise or counterclockwise
MP:0001398	obsolete backflips	OBSOLETE.
MP:0001399	hyperactivity	general restlessness or excessive movement; more frequent movement from one place to another or having an increased state of activity
MP:0001400	hyperresponsive	increased reaction to touch
MP:0001401	jumpy	marked by fitful, jerky movements
MP:0001402	decreased locomotor activity	general reduction in locomotor activity; reduced movement from one place to another
MP:0001404	no spontaneous movement	failure of neonates or embryos to initiate any voluntary or spontaneous change in position or posture, with or without external stimulus
MP:0001405	impaired coordination	reduced ability to execute integrated movements of muscle
MP:0001406	abnormal gait	abnormal pattern of movement of the limbs of animals, characterized by elements of progression, stability, speed and length over the ground
MP:0001407	short stride length	reduced average distance between steps
MP:0001408	stereotypic behavior	repetitive, invariant, perseverative motor patterns that do not appear to be purposeful
MP:0001409	increased stereotypic behavior	more frequent incidence of repetitive, invariant, perseverative motor patterns that do not appear to be purposeful
MP:0001410	head bobbing	repetitive up and down movement of the head
MP:0001411	spinning	repetitive rolling of the body
MP:0001412	excessive scratching	compulsive scraping of the skin, usually with the nails
MP:0001413	abnormal response to new environment	altered behavioral reaction associated with placing an animal in a new location
MP:0001414	obsolete Increased Response to New Environment	OBSOLETE.
MP:0001415	increased exploration in new environment	greater amount of time spent investigating new location
MP:0001416	obsolete Decreased Response to New Environment	OBSOLETE.
MP:0001417	decreased exploration in new environment	less amount of time spent investigating a new location
MP:0001418	obsolete open field locomotion abnormalities	OBSOLETE.
MP:0001421	obsolete touch escape	OBSOLETE.
MP:0001422	abnormal drinking behavior	an altered pattern of fluid consumption or altered preference for particular fluids
MP:0001423	abnormal liquid preference	the desire to drink more or less fluids than average, or to drink unusual fluids
MP:0001424	obsolete abnormal water consumption	OBSOLETE. drinking water in anomalous quantities
MP:0001425	abnormal alcohol consumption	aberrant behavioral-related or physiological-related intake of alcohol into the body
MP:0001426	polydipsia	abnormally large intake of fluids by mouth, usually due to excessive thirst that is relatively prolonged
MP:0001428	adipsia	failure to drink
MP:0001429	dehydration	excessive water loss from the body or from an organ or bodily part
MP:0001431	abnormal eating behavior	altered ability to consume foods or atypical consumption pattern
MP:0001432	abnormal food preference	the desire to eat more or less food than average, or to eat unusual foods
MP:0001433	polyphagia	eating to excess
MP:0001435	absent suckling reflex	inability to orient and open/close mouth in sucking pattern in response to external light touching or stroking of the chin
MP:0001436	abnormal suckling behavior	reduced ability or inability to exert suction by the mouth, or atypical suckling pattern
MP:0001437	no swallowing reflex	inability to pull food through the esophagus to the stomach in response to feeding
MP:0001438	aphagia	failure to eat
MP:0001440	abnormal grooming behavior	defects in the standard of behavior of cleaning and/or keeping outward appearance tidy (self, mate or offspring)
MP:0001441	increased grooming behavior	increased amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)
MP:0001442	decreased grooming behavior	reduced amount of time spent cleaning and/or keeping outward appearance tidy (self, mate or offspring)
MP:0001443	poor grooming	below average standard of cleaning and/or keeping outward appearance tidy (self, mate or offspring)
MP:0001444	obsolete compulsive biting	OBSOLETE.
MP:0001445	obsolete compulsive licking	OBSOLETE.
MP:0001446	abnormal whisker trimming behavior	anomaly in the behavior of plucking or biting off of the whiskers/vibrissae from other individuals of a cohort
MP:0001447	abnormal nest building behavior	deviation from the usual behavior of nesting animals to build sleeping nests out of any available materials, or of nesting animals to build nests to protect offspring
MP:0001448	obsolete abnormal mouse huddling behavior	OBSOLETE:any anomaly in the the usual tendency of mice to pile together when sleeping
MP:0001450	obsolete Altered Intelligence	OBSOLETE.
MP:0001451	obsolete Decreased Intelligence	OBSOLETE.
MP:0001452	obsolete Increased Intelligence	OBSOLETE.
MP:0001454	abnormal cued conditioning behavior	anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and a neutral stimulus (the conditioned stimulus (CS), usually an auditory cue or light flash)
MP:0001455	obsolete normal cued fear conditioning	OBSOLETE.
MP:0001456	obsolete impaired long term memory in cued fear conditioning test	OBSOLETE. altered ability to recall an association between an auditory cue and a foot shock over time; measured by 'freezing' of animal in response to auditory cue
MP:0001457	obsolete impaired long term memory in contextual fear test	OBSOLETE. altered ability to recall an association between a location and a foot shock over time; measured by 'freezing' of animal in response to auditory cue
MP:0001458	abnormal object recognition memory	anomaly in the ability to recognize objects that the animal has previously encountered; recognition is measured by relative amount of time exploring objects, which should decrease upon subsequent or multiple presentations of the same object when presented with novel objects at the same time
MP:0001459	obsolete impaired memory in novel object recognition test	OBSOLETE. reduced time spent exploring a novel object that replaced a training object after a specified retention time
MP:0001460	abnormal olfactory discrimination memory	anomaly in the ability to exhibit a differential response to olfactory stimuli that is achieved by the reinforcement of the desired response for each particular olfactory stimulus
MP:0001461	obsolete impaired memory in olfactory discrimination test	OBSOLETE. reduced food preference based on food recently smelled on the breath of other individuals
MP:0001462	abnormal avoidance learning behavior	anomaly in the ability to associate a previously neutral stimulus with an unpleasant or punishing stimuli so that the animal learns to avoid the previously neutral stimulus
MP:0001463	abnormal spatial learning	anomaly in the ability to ascertain or acquire spatial location information in order to improve navigation or other behavior using such location cues
MP:0001464	obsolete impaired learning in eight arm radial maze test	OBSOLETE. reduced ability to remember a sequence of previously visited feeding sites in an eight arm maze
MP:0001465	obsolete morris water maze	OBSOLETE.
MP:0001468	abnormal temporal memory	anomaly in the ability to recall temporal events and stimuli
MP:0001469	abnormal contextual conditioning behavior	anomaly in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)
MP:0001470	obsolete impaired long term memory in step-down avoidance test	OBSOLETE.
MP:0001471	obsolete large place fields	OBSOLETE.
MP:0001473	reduced long-term potentiation	less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells
MP:0001475	reduced long-term depression	less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons
MP:0001482	obsolete Increased Pupil Restriction	OBSOLETE.
MP:0001483	obsolete Decreased Pupil Restriction	OBSOLETE.
MP:0001485	abnormal pinna reflex	anomaly in the response to an auditory stimulus by a characteristic ear twitch
MP:0001486	abnormal startle reflex	aberrant threshold or reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch
MP:0001488	increased startle reflex	reduced threshold or more severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch
MP:0001489	decreased startle reflex	greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch
MP:0001490	abnormal vibrissae reflex	animals do not change position in response to stimulation of the whiskers
MP:0001491	unresponsive to tactile stimuli	absence of reflex action normally induced by touch or pain
MP:0001492	abnormal pilomotor reflex	anomaly in the involuntary bristling of hairs that occurs when an organism is cold or experiences strong emotions such as fear or awe
MP:0001496	audiogenic seizures	a reflex seizure triggered by loud noises
MP:0001499	abnormal kindling response	any anomaly in the long-lasting epileptogenic changes normally induced by daily sub threshold electrical brain stimulation, often used as an induced model for epilepsy
MP:0001500	decreased kindling response	fewer epileptogenic changes normally induced by daily sub threshold electrical brain stimulation
MP:0001501	abnormal sleep pattern	deviation from the normal wake/sleep cycle
MP:0001502	obsolete abnormal circadian rhythm	deviation from the normal 24 hour biological activity cycle
MP:0001503	obsolete abnormal strength/ posture	OBSOLETE.
MP:0001504	abnormal posture	atypical intentionally or habitually assumed position of the limbs or carriage of the body
MP:0001505	hunched posture	stooped low with the limbs pulled in close to the body and arched back
MP:0001506	limp posture	lack of rigidity of the carriage of the body
MP:0001507	obsolete positional passivity	OBSOLETE.
MP:0001508	obsolete abnormal body tone	OBSOLETE.
MP:0001509	obsolete abnormal body position	OBSOLETE.
MP:0001510	abnormal coat appearance	anomaly in the visual aspect of the coat or hair
MP:0001511	disheveled coat	coat that looks generally unkempt
MP:0001512	trunk curl	posture of the trunk in a curled position
MP:0001513	limb grasping	mice clasp front and/or hind feet almost immediately upon being lifted by tail
MP:0001514	obsolete abnormal footprint pathway	OBSOLETE.
MP:0001515	abnormal grip strength	altered ability to grasp and hold objects, often measured as time spent hanging from an object or wire
MP:0001516	abnormal motor coordination/balance	altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium
MP:0001522	impaired swimming	reduced ability or inability to swim
MP:0001523	impaired righting response	reduced ability or greater amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position
MP:0001524	impaired limb coordination	reduced ability to organize limb movements to execute complex maneuvers, such as walking
MP:0001525	impaired balance	reduced ability of an animal to maintain equilibrium
MP:0001526	abnormal placing response	altered ability to stretch and lift the forelimbs and head to grab a close edge
MP:0001527	athetotic walking movements	characterized by slow, writhing involuntary movements of flexion, extension, pronation and supination of the paws and toes
MP:0001529	abnormal vocalization	an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound
MP:0001530	obsolete Increased Vocalization	OBSOLETE.
MP:0001531	obsolete Decreased Vocalization	OBSOLETE.
MP:0001532	obsolete Physiology	OBSOLETE.
MP:0001533	abnormal skeleton physiology	any functional anomaly of the bony framework of the body
MP:0001539	decreased caudal vertebrae number	reduced number of the bony segments of the tail or tail remnant
MP:0001541	abnormal osteoclast physiology	any functional anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0001542	abnormal bone strength	change in the ability of bone to endure the application of force without yielding or breaking
MP:0001544	abnormal cardiovascular system physiology	any functional anomaly of the heart or vascular tissue
MP:0001545	abnormal hematopoietic system physiology	any functional anomaly of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins
MP:0001547	abnormal lipid level	any anomaly in the concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body
MP:0001548	hyperlipidemia	abnormally high concentration of lipids in the circulating blood
MP:0001552	increased circulating triglyceride level	greater concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver
MP:0001553	abnormal circulating free fatty acids level	any anomaly in the blood concentrations of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues
MP:0001554	increased circulating free fatty acids level	higher than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues
MP:0001556	increased circulating HDL cholesterol level	higher amount in the blood of the small lipoprotein:cholesterol complex that transports cholesterol out of the arteries and to the liver for reprocessing or excretion
MP:0001559	hyperglycemia	abnormally high concentration of glucose in the blood; generally refers to a pathological state
MP:0001560	abnormal circulating insulin level	any anomaly in the blood concentration of the polypeptide hormone, secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
MP:0001562	abnormal circulating calcium level	any anomaly in the concentration of calcium in the blood
MP:0001565	abnormal circulating phosphate level	any anomaly in the blood concentrations of the salt or ester of phosphoric acid
MP:0001566	increased circulating phosphate level	abnormally high concentrations of phosphates in the circulating blood
MP:0001569	abnormal circulating bilirubin level	any anomaly in the concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells
MP:0001570	abnormal circulating enzyme level	aberrant concentration in the blood of any of the proteins that act as catalysts for biological reactions
MP:0001573	abnormal circulating alanine transaminase level	aberrant concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2-ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction
MP:0001574	abnormal oxygen level	any anomaly in the concentration of the gaseous element that is essential for animal and plant life
MP:0001575	cyanosis	a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood
MP:0001577	anemia	less than normal levels of red blood cells and/or hemoglobin within red blood cells, or volume of packed red blood cells in the bloodstream, resulting in insufficient oxygenation of tissues and organs
MP:0001584	obsolete platelet storage pool deficiency	OBSOLETE. a blood coagulation disorder in which there is a decrease or lack of platelet dense bodies
MP:0001585	hemolytic anemia	deficiency of red cells resulting from an increased rate of erythrocyte destruction
MP:0001586	abnormal erythrocyte cell number	altered number of the cells that transport oxygen, red blood cells, per unit
MP:0001588	abnormal hemoglobin	defects in the levels or the function of the oxygen-carrying protein of erythrocytes
MP:0001589	abnormal mean corpuscular hemoglobin	anomalies in the average levels of hemoglobin contained in an erythrocyte
MP:0001596	hypotension	sustained low blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states
MP:0001598	abnormal blood viscosity	anomaly in the resistance to flow of the blood through the vessels
MP:0001599	abnormal blood volume	any anomaly in the amount of space occupied by the blood in the vessels
MP:0001601	abnormal myelopoiesis	anomaly in the process of, or atypical formation of myeloid cells from the pluripotent hematopoietic stem cells in the bone marrow from myeloid stem cells, including the production of leukocytes in blood, such as monocytes and granulocytes and precursor cells for macrophage and dendritic cells found in the lymphoid tissue
MP:0001602	impaired myelopoiesis	atypical process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells with the result of fewer of these cells being formed
MP:0001603	failure of myelopoiesis	missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells
MP:0001606	impaired hematopoiesis	atypical process of blood cell formation with the result of fewer of these cells being formed
MP:0001613	abnormal vasodilation	anomaly in the physiological widening of the lumen of the blood vessels by relaxing the underlying vascular smooth muscle
MP:0001614	abnormal blood vessel morphology	any structural anomaly of the network of tubes that carries blood through the body
MP:0001615	obsolete Decreased Vasculature	OBSOLETE.
MP:0001616	obsolete Increased Vasculature	OBSOLETE.
MP:0001619	abnormal vascular permeability	anomaly in the ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases
MP:0001622	abnormal vasculogenesis	aberrant process of the initial establishment of the vascular network
MP:0001625	cardiac hypertrophy	an increase in size of the cardiac tissue, not due to increased cell number
MP:0001627	abnormal cardiac output	anomaly in the blood volume pumped by each ventricle per minute (stroke volume x heart rate)
MP:0001629	abnormal heart rate	greater than or fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
MP:0001633	poor circulation	insufficient movement of blood throughout the body, often manifesting in cold and/or pale skin
MP:0001634	internal hemorrhage	blood loss in the interior of the body due to vessel rupture or dysmorphology
MP:0001636	irregular heartbeat	uneven timing of heart contraction
MP:0001637	obsolete cardiac arrest	OBSOLETE. complete cessation of cardiac activity
MP:0001641	obsolete death	OBSOLETE. cessation of life; cessation of integrated tissue and organ functions; a gradual process at the cellular level
MP:0001648	abnormal apoptosis	excessive or absent cell death in a particular tissue or cell type
MP:0001649	abnormal mandibular symphysis morphology	any structural anomaly of the fibrocartilagenous union of the two halves of the mandible (embryonic stages)
MP:0001650	abnormal seizure response to electrical stimulation	anomaly in the seizure activity response that is brought about by high or low frequency electrical stimulation
MP:0001651	obsolete necrosis	pathological death of cells or a portion of a tissue or organ; usually due to irreversible damage
MP:0001652	colonic necrosis	morphological changes resulting from pathological death of some or all colon tissue; usually due to irreversible damage
MP:0001653	gastric necrosis	morphological changes resulting from pathological death of gastric tissue; usually due to irreversible damage
MP:0001654	hepatic necrosis	morphological changes resulting from pathological death of liver tissue; usually due to irreversible damage
MP:0001655	multifocal hepatic necrosis	morphological changes resulting from multiple localized areas of pathological death of liver tissue; usually due to irreversible damage
MP:0001656	focal hepatic necrosis	morphological changes resulting from one or more localized areas of pathological death of some or all liver tissue; usually due to irreversible damage
MP:0001657	abnormal induced morbidity/mortality	differences from the expected diseased state or death caused by an external intervention
MP:0001658	increased mortality induced by gamma-irradiation	greater sensitivity to doses of ionizing radiation
MP:0001659	obsolete altered life span	OBSOLETE.
MP:0001661	extended life span	persistence of life for a longer period than is normal for an organism
MP:0001663	abnormal digestive system physiology	any functional anomaly of the organ system that converts ingested food to nutrients and energy
MP:0001664	abnormal digestion	any anomaly of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism
MP:0001665	chronic diarrhea	prolonged diarrhea
MP:0001666	abnormal intestinal absorption	any anomaly in the quantity or rate of any nutrient taken up from the contents of the intestine
MP:0001667	obsolete abnormal carbohydrate absorption	any anomaly in the ability of the body to take in substances composed of carbon, hydrogen, and oxygen according to the general formula Cn(H2O)n; sugars and starches are examples
MP:0001668	abnormal intestinal fructose absorption	any anomaly in the ability of the small intestine to absorb fructose into the bloodstream
MP:0001669	abnormal intestinal glucose absorption	any anomaly in the ability of the small intestine to absorb glucose into the bloodstream
MP:0001670	abnormal intestinal mineral absorption	any anomaly in the ability of the body to take up inorganic substances that have importance in body functions into the blood by absorption from the small intestine
MP:0001671	abnormal vitamin absorption	any anomaly in the ability to take in any of a group of organic substances, present in food, that are essential to normal metabolism
MP:0001672	abnormal embryo development	anomaly in the establishment of the characteristic configuration of the embryonic body
MP:0001674	abnormal germ layer development	abnormal development of the three primary germ layers of the embryo
MP:0001675	abnormal ectoderm development	any abnormality in the formation of the outer of the three primary germ layers of the embryo (the others being mesoderm and endoderm) that originates in the epiblast and is formed during gastrulation; ectoderm is in contact with the amnionic cavity and gives rise to two distinct lineages, i.e. the surface ectoderm and the neural ectoderm; it is the source of Rathke's pouch and forms the central and peripheral nervous systems, the sensory epithelia of the eye, ear, and nose, the epidermis and its appendages (nails and hair), the mammary, pituitary and subcutaneous glands, the tooth enamel, and the mucous membranes of the mouth and anus
MP:0001676	abnormal apical ectodermal ridge morphology	any structural anomaly of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme
MP:0001677	absent apical ectodermal ridge	missing the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme
MP:0001678	thick apical ectodermal ridge	increase in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme
MP:0001679	thin apical ectodermal ridge	decrease in the thickness of the multilayered ectodermal region at the tip of a limb bud necessary for the proper development of the underlying mesenchyme
MP:0001680	abnormal mesoderm development	failure or abnormality in the formation of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities
MP:0001683	absent mesoderm	absence of the middle of the three primary germ layers of the embryo (the others being ectoderm and endoderm) during gastrulation; mesoderm is the origin of connective tissues, myoblasts, blood, the cardiovascular and lymphatic systems, most of the urogenital system, and the lining of the pericardial, pleural, and peritoneal cavities
MP:0001684	abnormal axial mesoderm morphology	failure or abnormality in the formation of part of the middle of the three primary germ layers of the embryo which includes the prechordal mesoderm and the chordamesoderm and gives rise to the prechordal plate and to the notochord
MP:0001685	abnormal endoderm development	any abnormality in the formation of the innermost of the three primary germ layers of the embryo (the others being mesoderm and ectoderm) during gastrulation; endoderm gives rise to the epithelial lining of the gastrointestinal and respiratory tracts; the parenchyma of the tonsils, the liver, the thymus, the thyroid, the parathyroids, and the pancreas; the epithelial lining of the urinary bladder, urethra, and prostate; and the epithelial lining of the tympanic cavity, tympanic antrum, and auditory tube
MP:0001687	thin endoderm	reduced thickness of the innermost germ layer of the embryo
MP:0001688	abnormal somite development	any anomaly in the formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo; somites are transient structures - balls or blocks of paraxial mesoderm cells with an epithelial outer layer and a mesenchymal cell core - that emerge sequentially through a mesenchymal-to-epithelial transition (MET) from the morphologically unpatterned presomitic mesoderm; they give rise to the metameric anatomy of the vertebral column itself, and the associated skin, muscle and tendons
MP:0001689	incomplete somite formation	arrest of differentiation or patterning of the somites
MP:0001690	failure of somite differentiation	disorganized or absent somite tissue or somite pattern in development
MP:0001691	abnormal somite shape	anomaly in the characteristic surface outline or contour of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo
MP:0001693	failure of primitive streak formation	inability to form the epiblast ridge from which arises the germ layers of the embryo
MP:0001694	absent egg cylinders	inability of inner cell mass cells to grow towards the abembryonic pole to form a cylinder-like structure
MP:0001695	abnormal gastrulation	any anomaly in the development and invagination of the embryonic germ layers
MP:0001696	failure to gastrulate	inability to differentiate and invaginate the primary germ layers
MP:0001697	abnormal embryo size	any anomaly in the proportions of embryo compared to littermates (sensu Mus: up to E14, or the completion of organogenesis)
MP:0001698	decreased embryo size	smaller proportions of an embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)
MP:0001699	increased embryo size	larger proportions of embryo compared to littermates or other controls (sensu Mus: up to E14, or the completion of organogenesis)
MP:0001700	abnormal embryo turning	atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage during which the curvature of the entire trunk region is normally reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region
MP:0001701	incomplete embryo turning	arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage
MP:0001704	abnormal dorsal-ventral axis patterning	anomaly in the development or formation of the axis that runs from the front to the back surface of the body
MP:0001705	abnormal proximal-distal axis patterning	anomaly in the formation or development of a body structure, often a limb, in relation to the structure's proximity to the trunk or point of origin
MP:0001706	abnormal left-right axis patterning	anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ
MP:0001710	absent amniotic folds	failure of the amnion to form involutions
MP:0001711	abnormal placenta morphology	any structural anomaly of the organ of metabolic interchange between fetus and mother, which is partly of embryonic origin and partly of maternal origin
MP:0001712	abnormal placenta development	malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother
MP:0001713	decreased trophoblast giant cell number	fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta
MP:0001714	absent trophoblast giant cells	missing cells of the extraembryonic cell layer that contribute to the placenta
MP:0001715	placental labyrinth hypoplasia	decrease in the number of normal cells in normal arrangement in the placental labyrinth, typically resulting in decreased size
MP:0001716	abnormal placenta labyrinth morphology	any structural anomaly of the placental layers where embryonic blood vessels are surrounded by trophoblast cells and maternal blood, and is the site where the exchange of nutrients and waste products occurs between the maternal and fetal circulation
MP:0001717	absent ectoplacental cone	missing the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta
MP:0001718	abnormal visceral yolk sac morphology	any structural anomaly of the extraembryonic tissue membrane, formed from the visceral endoderm and the extraembryonic mesoderm, which is located ventral to the embryonic disc and is connected to the presumptive midgut of the embryo; the yolk that it contains is the site of embryonic hematopoiesis and vitelline circulation is involved in early embryonic circulation; it is the origin of the primordial germ cells
MP:0001719	absent vitelline blood vessels	absence of the vascular network that supplies the yolk sac
MP:0001720	obsolete excessive surface folding	OBSOLETE.
MP:0001721	absent visceral yolk sac blood islands	absence of the masses of developing blood cells attached to endothelium in the yolk sac
MP:0001722	pale yolk sac	bloodless yolk sac
MP:0001723	disorganized yolk sac vascular plexus	derangement in the pattern of the primary (honeycomb-like) vasculature of the yolk sac prior to remodeling into a mature vascular network
MP:0001724	abnormal extraembryonic endoderm formation	malformation of the derivative of the hypoblast cells that migrate into the blastocyst cavity, and line the cavity, giving rise to the primary and definitive yolk sacs; the extraembryonic endoderm fills the remaining cavity of the blastocyst
MP:0001725	abnormal umbilical cord morphology	any structural anomaly of the connective stalk between the fetus and the placenta
MP:0001726	abnormal allantois morphology	any structural anomaly fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels
MP:0001727	abnormal embryo implantation	anomaly in the process in which the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development
MP:0001728	failure of embryo implantation	inability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development
MP:0001729	impaired embryo implantation	impaired ability of the blastocyst and/or the uterine environment to successfully synchronize allowing attachment of the blastocyst to the epithelial lining of the uterus, its penetration through the epithelium and any subsequent physiological interactions necessary to sustain embryonic development
MP:0001730	embryonic growth arrest	the cessation of development beyond a particular stage
MP:0001731	abnormal postnatal growth	anomaly in reaching a developmental stage or stages after birth
MP:0001732	postnatal growth retardation	slow or limited development after birth
MP:0001734	obsolete abnormal endocrine organ	OBSOLETE. any structural anomaly of any of the glands that have no ducts, their secretions being absorbed directly into the blood
MP:0001739	abnormal adrenal gland secretion	altered ability of the surparenal gland to produce or secrete hormones
MP:0001740	failure of adrenal epinephrine secretion	inability of adrenal gland to deliver epinephrine into the blood stream
MP:0001741	obsolete decreased adrenaline synthesis	OBSOLETE. less than the normal formation of this catecholamine hormone that stimulates the adrenergic receptors
MP:0001742	absent circulating adrenaline	absence in the circulation of a catecholamine hormone that stimulates the adrenergic receptors and causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0001743	absent circulating noradrenaline	absence of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine
MP:0001744	hypersecretion of corticosterone	increased release of this adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion
MP:0001745	increased circulating corticosterone level	greater than the normal blood amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion
MP:0001746	abnormal pituitary secretion	anomaly in the production and/or release of biologically active substances from pituitary tissue
MP:0001747	hypersecretion of adrenocorticotropin	increased release of this pituitary hormone from the pituitary gland that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex
MP:0001748	increased circulating adrenocorticotropin level	elevated concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex
MP:0001749	suppressed circulating follicle stimulating hormone level	repression of secretion into the blood of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0001750	increased circulating follicle stimulating hormone level	higher than normal levels in the blood stream of FSH, the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0001751	increased circulating luteinizing hormone level	higher than the normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary
MP:0001752	abnormal hypothalamus secretion	altered ability of the hypothalamus to produce or release biologically active substances
MP:0001753	hypersecretion of corticotropin-releasing hormone	excessive release of this factor, which normally stimulates the pituitary to release adrenocorticotropic hormone, from the hypothalamus
MP:0001754	increased circulating corticotropin-releasing hormone level	higher than average amount of CRH in blood; CRH is normally released by the hypothalamus and stimulates the release of corticotropin by the anterior pituitary gland
MP:0001755	obsolete abnormal excretion physiology	OBSOLETE.
MP:0001756	abnormal urination	anomaly in the process in which parasympathetic nerves stimulate the bladder wall muscle to contract resulting in the expulsion of urine from the body
MP:0001758	abnormal urine glucose level	any change in the amount of glucose in the urine
MP:0001759	increased urine glucose level	a greater amount of glucose in the urine compared to the normal state
MP:0001760	abnormal urine enzyme level	any change in the level of enzymes in the urine
MP:0001761	abnormal urination pattern	increased or decreased frequency of urination episodes, or extended periods of anuria
MP:0001762	polyuria	increased volume of urine produced and excreted
MP:0001763	obsolete Infrequent Urination	OBSOLETE.
MP:0001764	abnormal homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the fluids and tissues
MP:0001765	abnormal ion homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the fluids and tissues
MP:0001766	obsolete abnormal aluminum level	OBSOLETE.
MP:0001770	abnormal iron level	any anomaly in the concentrations of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins and is an essential component of enzymes such as catalase, peroxidase, and various cytochromes
MP:0001771	abnormal circulating magnesium level	any anomaly in the blood concentration of magnesium
MP:0001775	abnormal selenium level	any anomaly in the concentration of selenium, which is required for glutathione peroxidase and other enzymes
MP:0001776	abnormal circulating sodium level	any anomaly in the concentration in the blood of sodium, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume
MP:0001777	abnormal body temperature homeostasis	any anomaly in the process in which an organism modulates or maintains its internal body temperature
MP:0001778	abnormal brown adipose tissue amount	anomaly in the amount of the thermogenic form of adipose tissue that is composed of brown adipocytes
MP:0001780	decreased brown adipose tissue amount	reduced quantity of the thermogenic form of adipose tissue that is composed of brown adipocytes
MP:0001781	abnormal white adipose tissue amount	anomaly in the quantity of the white fat-storing cells/tissue
MP:0001783	decreased white adipose tissue amount	reduced quantity of fat-storing cells/tissue
MP:0001784	abnormal fluid regulation	any anomaly in the control of intracellular and/or extracellular fluid
MP:0001785	edema	an accumulation of an excessive amount of watery fluid in cells or intercellular tissues
MP:0001786	skin edema	accumulation of an excessive amount of fluid in the skin layers or just underneath the skin
MP:0001787	pericardial edema	accumulation of watery fluid in the pericardial sac of the heart
MP:0001788	periorbital edema	accumulation of an excessive amount of fluid in the area around the orbit
MP:0001790	abnormal immune system physiology	deviation from the normal function of the immune system
MP:0001791	obsolete immunodeficiency	OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease
MP:0001792	impaired wound healing	reduced ability or inability to self-repair and close wounds
MP:0001793	abnormal susceptibility to infection	a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens
MP:0001794	obsolete Bacterial	OBSOLETE.
MP:0001795	obsolete Gram Negative	OBSOLETE.
MP:0001796	obsolete Gram Positive	OBSOLETE.
MP:0001797	obsolete Opportunistic Infections of the Intestinal Tract	OBSOLETE.
MP:0001798	impaired macrophage phagocytosis	reduced ability of macrophage phagocytic cells to internalize particulate matter
MP:0001799	obsolete Viral	OBSOLETE.
MP:0001800	abnormal humoral immune response	any functional anomaly of the aspect of immunity that is mediated by secreted antibodies produced in the cells of the B lymphocyte lineage (B cell) and the accessory processes that accompany it, including Th2 activation and cytokine production, germinal center formation and isotype switching, affinity maturation and memory cell generation; it also refers to the effector functions of antibody, which include pathogen and toxin neutralization, classical complement activation, and opsonin promotion of phagocytosis and pathogen elimination
MP:0001802	arrested B cell differentiation	inability to produce mature B cells, and accumulation of B cell precursors
MP:0001804	obsolete abnormal complement protein physiology	OBSOLETE. functional anomaly of any of the complement proteins
MP:0001805	decreased IgG level	less than normal immunoglobulin class G level
MP:0001806	decreased IgM level	less than normal immunoglobulin class M level
MP:0001807	decreased IgA level	less than normal immunoglobulin class A level
MP:0001808	obsolete B cell Immunodeficiency	OBSOLETE.
MP:0001809	obsolete Abnormal Immunoglobulin Production	OBSOLETE.
MP:0001817	obsolete abnormal antibody production	OBSOLETE.
MP:0001818	obsolete abnormal antibody titer	OBSOLETE.
MP:0001819	abnormal immune cell physiology	any functional anomaly of the cells of the immune system
MP:0001820	obsolete abnormal activated B cell number	OBSOLETE.
MP:0001823	thymus hypoplasia	decrease in the number of normal cells in normal arrangement in the thymus, typically resulting in decreased size
MP:0001824	abnormal thymus involution	premature or late decline in thymic function normally associated with advancing age
MP:0001825	arrested T cell differentiation	failure of T cell formation to proceed past a defined stage
MP:0001828	abnormal T cell activation	anomaly in the process of producing effector T cells from naive T cells
MP:0001829	increased activated T cell number	greater than normal numbers of effector T cells
MP:0001830	decreased activated T cell number	reduced numbers of effector T cells
MP:0001831	obsolete T cell immunodeficiency	OBSOLETE.defective immune response due to defective T-lymphocyte response
MP:0001832	obsolete CD4-Positive cell immunodeficiency	OBSOLETE.
MP:0001833	obsolete CD8- Positive cell immunodeficiency	OBSOLETE.
MP:0001834	obsolete macrophage immunodeficiency/impairment	OBSOLETE.
MP:0001835	abnormal antigen presentation	aberration in the process by which by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex
MP:0001836	abnormal antigen presentation via MHC class I	anomaly in the process by which peptide, bound to major histocompatibility complex class I, is presented to lymphocytes at the surface of antigen presenting cells
MP:0001837	defective assembly of class I molecules	impaired production of major histocompatibility complex class I molecules
MP:0001838	defective intracellular transport of class I molecules	impaired ability to move major histocompatibility complex class I molecules to the cell surface
MP:0001839	abnormal level of surface class I molecules	deviation from the normal concentration of major histocompatibility complex class I molecules expressed at the cell surface
MP:0001840	increased level of surface class I molecules	greater than normal expression of major histocompatibility complex class I molecules at the cell surface
MP:0001841	decreased level of surface class I molecules	reduced expression of major histocompatibility complex class I molecules at the cell surface
MP:0001842	obsolete inability to present cytosolic antigens to Class-I restricted cytotoxic T cells	OBSOLETE.
MP:0001844	autoimmune response	condition in which cells and/or antibodies arise from and are directed against one's own tissues
MP:0001845	abnormal inflammatory response	aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues
MP:0001846	increased inflammatory response	greater than expected response to injury, infection, or insult
MP:0001847	brain inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the brain
MP:0001848	choroid inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera
MP:0001849	ear inflammation	local accumulation of fluid, plasma proteins and leukocytes in the ear
MP:0001850	increased susceptibility to otitis media	greater likelihood of middle ear inflammation, with an accumulation of a thick, mucous-like fluid; usually associated with a viral or bacterial respiratory infection
MP:0001851	eye inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the eye
MP:0001852	conjunctivitis	inflammation of the mucous membrane that lines the inner surface of the eyelids and the front of the eyeball
MP:0001853	heart inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the heart
MP:0001854	atrial endocarditis	inflammation affecting the atrial chambers of the heart
MP:0001855	abnormal atrial thrombosis	any anomaly in the formation or presence of one or more thrombi in the atria of the heart
MP:0001856	myocarditis	inflammation of the heart walls
MP:0001857	pericarditis	inflammation of the pericardium, the fibroserous sac surrounding the heart and the roots of the great vessels
MP:0001858	intestinal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the intestine
MP:0001859	kidney inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the kidney
MP:0001860	liver inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the liver
MP:0001861	lung inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the lung
MP:0001862	interstitial pneumonia	any of a group of inflammatory and fibrotic disorders of the lower respiratory tract, primarily affecting the supporting framework of the lung, including the alveolar wall, but may also involve the small airways and blood vessels of the lung parenchyma
MP:0001863	blood vessel inflammation	local accumulation of fluid, plasma proteins, and leukocytes in a blood vessel
MP:0001864	vascular inflammation	inflammation of any blood and/or lymphatic vessel
MP:0001866	nasal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages
MP:0001867	rhinitis	inflammation of the mucous membrane of the nose
MP:0001868	ovary inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the ovary
MP:0001869	pancreas inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the pancreas
MP:0001870	salivary gland inflammation	local accumulation of fluid, plasma proteins, and leukocytes in one or more salivary glands
MP:0001872	sinus inflammation	increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens
MP:0001873	stomach inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the stomach
MP:0001874	acanthosis	diffuse hyperplasia of the spinous layer of the skin
MP:0001875	testis inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the testis
MP:0001876	decreased inflammatory response	less than expected response to injury, infection, or insult
MP:0001877	obsolete dysregulated inflammatory response	OBSOLETE.
MP:0001879	abnormal lymphatic vessel morphology	any structural anomaly of any component of the network of vessels that carries lymph around the body
MP:0001881	abnormal mammary gland physiology	any functional anomaly of the compound, alveolar and apocrine milk-secreting gland that lies within the breast
MP:0001882	abnormal lactation	atypical production of milk from the mammary gland
MP:0001883	increased mammary adenocarcinoma incidence	higher than normal incidence of malignant tumors of the mammary gland
MP:0001884	mammary gland alveolar hyperplasia	increase in the number of normal cells in normal arrangement in the mammary gland alveoli, typically resulting in increased size
MP:0001885	mammary gland duct hyperplasia	increase in the number of normal cells in normal arrangement in the mammary gland ducts, typically resulting in increased size
MP:0001886	obsolete nervous system physiology abnormalities	OBSOLETE.
MP:0001889	delayed brain development	the delay or slower progress of the growth and differentiation of the brain
MP:0001890	anencephaly	anomaly that occurs when the anterior neuropore of the neural tube fails to close, resulting in the congenital partial or complete absence of the cranial vault accompanied by absence of overlying tissues, including the brain and cerebral hemispheres, skull and scalp; in affected organisms, the forebrain remains in contact with the amniotic fluid and subsequently degenerates, including the cerebrum (areas responsible for cognition); any remaining brain tissue, such as the brain stem, is often exposed
MP:0001891	hydrocephaly	excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma
MP:0001893	non-obstructive hydrocephaly	abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system
MP:0001895	obsolete abnormal hippocampus function	OBSOLETE. any anomaly in the activity of the deep lying structure of the cerebrum involved with memory storage
MP:0001898	abnormal long-term depression	change from the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of neurons
MP:0001899	absent long-term depression	lack of the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons
MP:0001900	impaired synaptic plasticity	decrease or inability of a synapse to change its strength as a result of successive activations
MP:0001901	absence of NMDA-mediated synaptic currents	absence of a measured amplitude, current density or duration of response to stimulation of NMDA receptors
MP:0001902	reduced NMDA-mediated synaptic currents	reduction in the measured amplitude, current density or duration of response to stimulation of NMDA receptors
MP:0001903	obsolete reduced NMDA receptor glycine affinity: hippocampus	OBSOLETE.
MP:0001904	obsolete impaired GABA receptor mediated fast inhibition	OBSOLETE.
MP:0001905	abnormal dopamine level	greater or less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary
MP:0001906	increased dopamine level	greater than the normal amount of dopamine, a catecholamine neurotransmitter and neurohormone that is derived from tyrosine and is the precursor to norepinephrine and epinephrine; it functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary
MP:0001907	obsolete abnormal cerebellar function	OBSOLETE. any anomaly in the activity of the portion of the brain in the back of the head between the cerebrum and the pons that controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills
MP:0001908	abnormal somatosensory cortex physiology	any functional anomaly of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface
MP:0001909	reduced NMDA receptor mediated synaptic activity in barrel cortex	lower than normal levels of excitatory synaptic current in the barrel cortex
MP:0001911	abnormal cerebrospinal fluid production	anomaly in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord
MP:0001912	increased cerebrospinal fluid production	increase in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord
MP:0001913	decreased cerebrospinal fluid production	reduction in the normal output of the fluid that fills the ventricles and other cavities of the brain and spinal cord
MP:0001914	hemorrhage	loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels
MP:0001915	intracranial hemorrhage	bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces
MP:0001916	intracerebral hemorrhage	bleeding within the cerebrum
MP:0001917	intraventricular hemorrhage	bleeding into the brain ventricles
MP:0001919	abnormal reproductive system physiology	any functional anomaly of the organs associated with producing offspring
MP:0001921	reduced fertility	diminished physiological ability to produce live offspring
MP:0001922	reduced male fertility	reduced physiological ability of a male organism to produce live offspring
MP:0001923	reduced female fertility	reduced physiological ability of a female organism to produce live offspring
MP:0001924	infertility	physiological inability to produce live offspring
MP:0001925	male infertility	physiological inability of a male organism to produce live offspring
MP:0001926	female infertility	physiological inability of a female organism to produce live offspring
MP:0001927	abnormal estrous cycle	failure of progression or aberrant timing of the regular female reproductive cycle of non-primate placental mammals that is under hormonal control and includes a period of heat (mating receptivity), followed by ovulation and complex changes in the reproductive tract, followed by reabsorption of the endometrium if pregnancy does not occur
MP:0001928	abnormal ovulation	aberration in the release of an ovum from a rupturing Graafian follicle, normally regulated by a surge in luteinizing hormone
MP:0001929	abnormal gametogenesis	defective formation or differentiation of germ cells
MP:0001930	abnormal meiosis	anomaly in the process of nuclear division that results in gametes with one half the normal number of the original cell
MP:0001931	abnormal oogenesis	atypical formation or failure to form the female germ cells
MP:0001932	abnormal spermiogenesis	anomaly in the process by which a spermatid transforms into a functional spermatozoon
MP:0001933	abnormal litter size	deviation from the normal number of live born pups in a litter
MP:0001934	increased litter size	greater numbers of live born pups in a litter compared to average
MP:0001935	decreased litter size	fewer live born pups in a litter compared to average
MP:0001937	abnormal sexual maturation	a delay or a block in the development of the sexual organs at a given age
MP:0001938	delayed sexual maturation	immaturity of the sexual organs at a given age
MP:0001939	secondary sex reversal	secondary sexual phenotype is not consistent with the chromosomal sex, i.e., internal and/or external genitalia are inconsistent with chromosomal sex
MP:0001940	testis hypoplasia	decrease in the number of normal cells in normal arrangement in the testis, typically resulting in decreased size
MP:0001942	abnormal lung volume	anomaly in the amount of air that the lungs contain at various points of the respiratory cycle
MP:0001943	abnormal respiration	anomaly in the movement of gases into and out of the lung
MP:0001944	abnormal pancreas morphology	any structural anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream
MP:0001945	bronchoconstriction	reduction in the caliber of the bronchus or bronchi
MP:0001947	abnormal mucociliary clearance	anomaly in the mechanism that removes mucus and other foreign particles and microorganisms from the lungs by directed ciliary movement and secretory activity of the tracheobronchial submucosal glands
MP:0001948	vesicoureteral reflux	the retrograde flow of urine from the bladder into the ureters and kidneys
MP:0001949	obsolete abnormal respiratory dead space	OBSOLETE. anomaly in the section of the respiratory tract that does not exchange oxygen and carbon dioxide with pulmonary capillary blood
MP:0001950	abnormal respiratory sounds	any anomaly in the noises heard over any part of the respiratory tract
MP:0001951	abnormal breathing pattern	irregular or atypical breathing pattern, or absence of breathing
MP:0001952	increased airway responsiveness	more easily provoked into bronchoconstriction in bronchial provocation tests
MP:0001953	respiratory failure	cessation of or failure to commence breathing
MP:0001954	respiratory distress	physical difficulty or impaired ability to breathe; signs include: shortness of breath, labored breathing, gasping, increased work of breathing, inadequate respiratory effort, and/or irregular breathing
MP:0001956	hypopnea	breathing that is shallower and/or slower than normal
MP:0001957	apnea	temporary cessation of breathing; sometimes episodic
MP:0001958	emphysema	an abnormal condition of the lung characterized by permanent enlargement of airspaces distal to the terminal bronchioles, accompanied by destruction of their walls and without obvious fibrosis; results in decreased respiratory function including increased air retention and reduced exchange of gases
MP:0001959	obsolete sensory system physiology/response abnormalities	OBSOLETE.
MP:0001961	abnormal reflex	anomaly in an involuntary response to a peripheral stimulus
MP:0001963	abnormal hearing physiology	any functional anomaly in the ability to perceive auditory stimuli
MP:0001964	obsolete abnormal auditory threshold	OBSOLETE. change in the average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency
MP:0001965	obsolete increased auditory threshold	OBSOLETE. a greater than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency
MP:0001966	obsolete decreased auditory threshold	OBSOLETE. a lower than average point at which one may first detect electrical activity generated by neurons in the ascending auditory system by using computer-averaged responses to short tone bursts at varying frequency
MP:0001967	deafness	inability to hear; the ability to detect and/or recognize certain frequencies of sound is completely impaired
MP:0001968	abnormal touch/ nociception	change in the ability to sense contact with objects or in the ability to sense pain, most often registered by mechanoreceptors in the skin and mucous membranes
MP:0001970	abnormal pain threshold	increased or decreased average level of perception of pain
MP:0001973	increased thermal nociceptive threshold	a greater than average point at which thermal pain sensation is first detectable
MP:0001974	obsolete toe pinch	OBSOLETE.
MP:0001975	obsolete tail pinch	OBSOLETE.
MP:0001977	obsolete tail flick	OBSOLETE.
MP:0001978	obsolete prolonged latency in tail flick test	OBSOLETE.
MP:0001980	abnormal chemically-elicited antinociception	change in the analgesic effect of chemical substances
MP:0001981	increased chemically-elicited antinociception	greater than the normal analgesic effect of chemical substances
MP:0001982	decreased chemically-elicited antinociception	less than the normal analgesic effect of chemical substances
MP:0001983	abnormal olfactory system physiology	any functional anomaly of the system relating to smell
MP:0001984	abnormal olfaction	anomaly in the ability to smell
MP:0001985	abnormal gustatory system physiology	any functional anomaly in the perception of taste
MP:0001986	abnormal taste sensitivity	changes in the ability to perceive a particular flavor(s) or suggestion of something imparting a flavor by the chemoreceptors of the gustatory system
MP:0001987	alcohol preference	predilection to ingest alcohol over other substances
MP:0001988	cocaine preference	predilection to ingest cocaine over other substances
MP:0001989	obsolete saccharin versus water	OBSOLETE.
MP:0001990	obsolete water versus saccharin	OBSOLETE.
MP:0001993	abnormal blinking	anomaly in the normal reflex of closing the eyes frequently and rapidly
MP:0001994	increased blinking frequency	greater number of occurrences of the normal reflex of closing the eyes frequently and rapidly
MP:0001995	decreased blinking frequency	reduced number of occurrences of the normal reflex of closing the eyes frequently and rapidly
MP:0001997	obsolete Increased Pupil Constriction	OBSOLETE.
MP:0001998	obsolete Decreased Pupil Constriction	OBSOLETE.
MP:0001999	photosensitivity	alterations in the response to sunlight or UV irradiation, especially sensitivity of the eyes
MP:0002001	blindness	loss of the sense of sight
MP:0002002	obsolete abnormal response to visual cliff	OBSOLETE.
MP:0002003	miotic pupil	decreased diameter of one or both pupils due to abnormal constriction of the muscles of the iris
MP:0002006	neoplasm	the observable morphological and physiological characteristics of  a benign or malignant tissue growth resulting from uncontrolled cell proliferation in a mammalian organism that are manifested through development and lifespan
MP:0002007	increased cellular sensitivity to gamma-irradiation	increased incidence of cell death following exposure to gamma-irradiation
MP:0002009	preneoplasia	state preceding the pathological process resulting in a neoplasm; does not necessarily imply cancerous development
MP:0002010	obsolete hepatic microgranulomas	OBSOLETE.
MP:0002012	increased trichofolliculoma incidence	greater than the expected number of dome-shaped hamartoma tumors which contain multiple abortive and/or misaligned hair follicles
MP:0002013	increased pilomatricoma incidence	greater than the expected number of neoplasms that arise from hair matrix cells occurring in a specific population in a given time period; pilomatricoma is an encapsulated tumor containing irregularly shaped, lobules of cells separated by fibrovascular connective tissue stroma; two distinct cell populations comprise this tumor, basaloid cells with scant cytoplasm located towards the periphery and the ghost (or shadow) cells occupying the central portion
MP:0002014	increased papilloma incidence	greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells occurring in a specific population in a given time period
MP:0002015	epithelioid cyst	presence of one or more abnormal membranous sacs in an epithelium
MP:0002016	ovary cyst	presence of one or more fluid-filled membranous sacs within the ovary
MP:0002018	increased malignant tumor incidence	higher than normal incidence of locally invasive, destructive and metastatic tumors
MP:0002019	abnormal tumor incidence	deviation from the expected number of abnormal growths in a specific population
MP:0002020	increased tumor incidence	greater than the expected number of neoplasms in a specific population in a given time period, usually of a specific type
MP:0002021	increased incidence of induced tumors	higher than normal frequency of tumor incidence induced by a carcinogen, mutagen or virus
MP:0002023	increased B cell derived lymphoma incidence	higher than normal incidence of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes
MP:0002024	increased T cell derived lymphoma incidence	higher than normal incidence of a group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes
MP:0002025	obsolete B cell/T cell derived lymphoma	OBSOLETE. group of heterogeneous lymphoid tumors representing malignant transformations of both B-lymphocytes and T-lymphocytes
MP:0002026	increased leukemia incidence	higher than normal incidence of a cancer characterized by progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood
MP:0002027	increased lung adenocarcinoma incidence	greater than the expected number of a malignant neoplasm of epithelial cells in the lung, usually with a glandular organization, occurring in a specific population in a given time period
MP:0002030	increased neurofibrosarcoma incidence	greater than the expected number of a highly aggressive malignant neoplasm arising from the fibrous connective tissue surrounding peripheral nerves, in a specific population in a given time period
MP:0002031	increased adrenal gland tumor incidence	greater than the expected number of neoplams in the adrenal gland occurring in a specific population in a given time period
MP:0002032	increased sarcoma incidence	greater than the expected number of a connective tissue neoplasm associated with the proliferation of embryonically-derived mesodermal cells, occurring in a specific population in a given time period
MP:0002033	increased malignant triton tumor incidence	greater than the expected number of a malignant tumor with neurogenic and myogenic differentiation, occurring in a specific population in a given time period; usually arises in tissues of neural crest origin
MP:0002035	increased leiomyosarcoma incidence	greater than the expected number of a malignant tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period
MP:0002036	increased rhabdomyosarcoma incidence	greater than the expected number of a malignant tumor derived from skeletal (striated) muscle, occurring in a specific population in a given time period
MP:0002037	increased fibrohistocytoma incidence	greater than the expected number of slowly growing skin nodules derived from cellular fibrous tissue occurring in a specific population in a given time period; these often surround capillaries
MP:0002038	increased carcinoma incidence	greater than the expected number of any of a variety of malignant neoplasms arising from epithelial cells, occurring in a specific population in a given time period; carcinomas are usually glandular or squamous in origin
MP:0002039	increased neuroblastoma incidence	greater than the expected number of a malignant neoplasm characterized by immature nerve cells of embryonic type, occurring in a specific population in a given time period
MP:0002041	increased pituitary adenoma incidence	greater than the expected number of benign neoplasms of the pituitary, occurring in a specific population in a given time period
MP:0002042	obsolete hemotologic neoplasia	OBSOLETE.
MP:0002043	increased colon hamartoma incidence	greater than the expected number of benign focal malformations in the colon in a specific population in a given time period; results from faulty colonic development, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site
MP:0002044	increased colon adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the colon, occurring in a specific population in a given time period
MP:0002045	increased renal cystadenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising in the kidney, occurring in a specific population in a given time period
MP:0002047	increased hepatic hemangioma incidence	greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the liver, occurring in a specific population in a given time period
MP:0002048	increased lung adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the lung, occurring in a specific population in a given time period
MP:0002049	increased extremity angiosarcoma incidence	higher than normal incidence of malignant neoplasm of soft tissues; thought to arise from endothelial cells of blood vessels
MP:0002050	increased pheochromocytoma incidence	greater than the expected number of a benign neoplasm derived from adrenal medullary cells, occurring in a specific population in a given time period; usually associated with hypertension
MP:0002051	increased skin papilloma incidence	greater than the expected number of a circumscribed, benign epithelial tumor projecting from the surrounding surface, occurring in a specific population in a given time period
MP:0002052	decreased tumor incidence	less than the expected number of neoplasms in a specific population in a given time period
MP:0002053	decreased incidence of induced tumors	reduced frequency of tumor incidence induced by a carcinogen, mutagen or virus
MP:0002054	obsolete disease states	OBSOLETE.
MP:0002055	obsolete Diabetes	OBSOLETE. either insipidus or mellitus. Having in common the symptoms of polyuria
MP:0002056	obsolete Insulin dependent diabetes	Obsolete. Characterized by polydipsia, polyuria, increased appetite, weight loss, low plasma insulin levels, and episodic ketoacidosis
MP:0002057	obsolete Non-insulin dependent diabetes	OBSOLETE. Type II, adult onset. mild form gradual onset, usually in obese individuals. Plasma insulin levels are normal to high , but low in relation to plasma glucose levels. Responsive to dietary regulation or oral hypoglycemic agents, but diabetic complications and degenerative changes can develop
MP:0002058	neonatal lethality	death within the neonatal period after birth (Mus: P0)
MP:0002059	abnormal seminal vesicle morphology	any structural anomaly of either of the paired sac-like glandular structures situated posterolateral to the urinary bladder in the male and functioning as part of the reproductive system; each sac is pyramidal in shape and convoluted in appearance and at the anterior extremity becomes constricted into a narrow straight duct that joins the ipsilateral vas deferens to form the ejaculatory duct; seminal vesicles secrete seminal fluid and nourish and promote the movement of spermatozoa through the urethra
MP:0002060	abnormal skin morphology	any structural anomaly of the membranous protective covering of the body
MP:0002061	abnormal aggression-related behavior	domineering, assaultive or forceful physical action
MP:0002062	abnormal associative learning	anomaly in the ability to change the frequency or form of a behavior as a result of the influence of the environment
MP:0002063	abnormal learning/memory/conditioning	altered ability to receive, store, process or recall informational stimuli
MP:0002064	seizures	sudden and often acute manifestation of epileptic attack, sometimes convulsive
MP:0002065	abnormal fear/anxiety-related behavior	altered response in tests for fear or anxiety related behaviors
MP:0002066	abnormal motor capabilities/coordination/movement	altered ability to coordinate voluntary movement or repetitive, compulsive movements
MP:0002067	abnormal sensory capabilities/reflexes/nociception	inability or altered ability to respond to a sensory stimulus
MP:0002068	abnormal parental behavior	altered behavior of animals that affects the ability of offspring to survive
MP:0002069	abnormal consumption behavior	altered ability or inability to eat or drink, or unusual choice or avoidance of foods or drink
MP:0002070	obsolete abnormal sleep pattern/circadian rhythm	OBSOLETE. deviation from the normal 24 hour biological activity cycle including the wake/sleep cycle
MP:0002071	obsolete other abnormal behavior	OBSOLETE. abnormal behaviors not attributable to other categories
MP:0002072	obsolete neurological/behavioral: no defect detected	OBSOLETE. no anomaly observed in neurological or behavioral tests
MP:0002073	abnormal hair growth	any anomaly in the amount of hair or abnormal onset of hair growth cycle or development, or abnormal hair pattern
MP:0002074	abnormal hair texture	irregular or unusual appearance of the structure of the hair
MP:0002075	abnormal coat/hair pigmentation	irregular or unusual pigmentation of the hair
MP:0002076	obsolete abnormal hair follicle structure/orientation	OBSOLETE. any structural anomaly or misalignment of the epidermis from which the hair shaft develops
MP:0002078	abnormal glucose homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of glucose in the fluids and tissues
MP:0002079	increased circulating insulin level	greater than normal levels of insulin in blood
MP:0002080	prenatal lethality	death anytime between fertilization and birth (Mus: approximately E18.5)
MP:0002081	perinatal lethality	death anytime within the perinatal period (Mus: E18.5 through postnatal day 1)
MP:0002082	postnatal lethality	premature death anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)
MP:0002083	premature death	death after weaning age, but before the normal life span (Mus: after 3 weeks of age)
MP:0002084	abnormal developmental patterning	abnormal systematic arrangement of the developing body along an axis
MP:0002085	abnormal embryonic tissue morphology	any structural anomaly of the embryonic tissue part of the whole embryo
MP:0002086	abnormal extraembryonic tissue morphology	any structural anomaly of the membranes involved with embryonic protection and nutrition
MP:0002087	obsolete embryogenesis: no defect detected	OBSOLETE. no anomaly observed in examination of embryonic development
MP:0002088	abnormal embryonic growth/weight/body size	limited or accelerated growth or development apparent during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)
MP:0002089	abnormal postnatal growth/weight/body size	increased or decreased average body size, weight or growth characteristic abnormalities manifesting after birth
MP:0002090	abnormal vision	any anomaly in the ability to see
MP:0002091	obsolete eye: no defect detected	OBSOLETE. no anomaly observed in examination of eye tissue
MP:0002092	abnormal eye morphology	any structural anomaly of the spheroid organ and optic nerve that serves to detect light
MP:0002093	obsolete abnormal cornea/lens morphology	OBSOLETE. any dysmorphology or complete or partial opacity of the lens or cornea
MP:0002094	obsolete coat: no defect detected	OBSOLETE. no anomaly observed in examination of coat
MP:0002095	abnormal skin pigmentation	anomaly in the coloration of the skin due to changes in the amount, shape, or distribution of cells producing pigment
MP:0002096	obsolete abnormal skin condition/ morphology	OBSOLETE. any structural anomaly or atypical condition of the skin
MP:0002097	obsolete skin: no defect detected	OBSOLETE. no anomaly observed in examination of skin
MP:0002098	abnormal vibrissa morphology	any structural anomaly of the stiff hairs projecting from the face around the nose of most mammals which act as touch receptors
MP:0002099	obsolete vibrissae: no defect detected	OBSOLETE. no anomaly observed in examination of whiskers
MP:0002100	abnormal tooth morphology	any anomaly in the size, shape or structure of the hard or soft tissues of the skeletal element within the mouth that is composed of dentine and used to procure or masticate food
MP:0002101	obsolete teeth: no defect detected	OBSOLETE. no anomaly observed in examination of teeth
MP:0002102	abnormal ear morphology	any structural anomaly of any of the structures involved in the ear or vestibular system
MP:0002103	obsolete ears: no defect detected	OBSOLETE. no anomaly observed in examination of auditory tissue or in hearing assessment
MP:0002106	abnormal muscle physiology	any functional anomaly of the muscle, not due to an anatomical defect
MP:0002107	obsolete musculature: no defect detected	OBSOLETE. no anomaly observed in examination of muscle tissue or in physiological assessment
MP:0002108	abnormal muscle morphology	any structural anomaly of the contractile tissue that produces movement in animals
MP:0002109	abnormal limb morphology	any structural anomaly of the projecting paired appendages of an animal trunk, used in particular for movement and grasping; usually denotes the arm and/or legs in mammalian species
MP:0002110	abnormal digit morphology	any structural anomaly of the fingers or toes
MP:0002111	abnormal tail morphology	any structural anomaly of the flexible elongated appendage located at the caudal end of the torso in many species; it is usually continuous with the vertebral column
MP:0002112	obsolete extremities: no defect detected	OBSOLETE. no anomaly observed in examination of extremities
MP:0002113	abnormal skeleton development	any anomaly in the formation of bone tissue
MP:0002114	abnormal axial skeleton morphology	any structural anomaly of the articulated bones of the cranium and vertebral column
MP:0002115	abnormal limb bone morphology	any structural anomaly of the limb or autopod bones
MP:0002116	abnormal craniofacial bone morphology	any structural anomaly of the cranial or facial bones
MP:0002117	obsolete skeletal: no defect detected	OBSOLETE. no anomaly observed in examination of bones and/or skeleton
MP:0002118	abnormal lipid homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of lipids in the fluids and tissues
MP:0002119	dipsosis	excessive desire to drink, or to drink unusual fluids
MP:0002121	obsolete other metabolic defect	OBSOLETE. altered chemical and physical processes of the body or of a tissue, not due to lipid or glucose chemistry
MP:0002122	obsolete metabolism: no defect detected	OBSOLETE. no anomaly observed in examination of metabolic function
MP:0002123	abnormal definitive hematopoiesis	abnormal development of blood cells in the fetal and adult organism; in the fetus cells develop in the aorta, genital ridge and mesonephros region and later in the liver; in adults cells normally develop in the bone marrow and lymphatic tissues
MP:0002126	obsolete hematology: no defect detected	OBSOLETE. no anomaly observed in examination of hematological development or function
MP:0002127	abnormal cardiovascular system morphology	any structural anomaly of the heart or vascular tissue
MP:0002128	abnormal blood circulation	failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart
MP:0002131	obsolete heart/cardiovascular system: no defect detected	OBSOLETE. no anomaly observed in examination of heart or vascular tissue or in cardiovascular function
MP:0002132	abnormal respiratory system morphology	any structural anomaly of pulmonary tissues
MP:0002133	abnormal respiratory system physiology	any functional anomaly of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment
MP:0002134	obsolete respiratory system: no defect detected	OBSOLETE. no anomaly observed in examination of lung and other respiratory tissues
MP:0002135	abnormal kidney morphology	any structural anomaly of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine
MP:0002136	abnormal kidney physiology	any functional anomaly and/or activity of either of the two excretory organs that filter wastes (especially urea) from the blood and excrete them and water in urine
MP:0002137	obsolete kidney/renal system: no defect detected	OBSOLETE. no anomaly observed in examination of kidney and other renal tissues
MP:0002138	abnormal hepatobiliary system morphology	any structural anomaly of any of the tissues of the liver or biliary system
MP:0002139	abnormal hepatobiliary system physiology	any functional anomaly of the tissues of the liver or biliary system
MP:0002140	obsolete liver/hepatic system: no defect detected	OBSOLETE. no anomaly observed in examination of liver or other hepatic tissues
MP:0002143	obsolete digestive system: no defect detected	OBSOLETE. no anomaly obsesrved in the function of or in any region of the digestive system
MP:0002144	abnormal B cell differentiation	atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors
MP:0002145	abnormal T cell differentiation	atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors
MP:0002146	obsolete immune system: other dysmorphology	OBSOLETE. abnormal development of lymphocytes or lymphatic tissue (other than B or T lymphocytes) resulting in morphological abnormality
MP:0002147	obsolete immune system: immunodeficiency	OBSOLETE. defective immune response; can be primary due to defect in immune system or secondary due to disease
MP:0002148	abnormal hypersensitivity reaction	immune response that results in tissue injury
MP:0002149	obsolete immune system: other functional anomaly	OBSOLETE. altered immune response not due to anatomical defect, immunodeficiency or hypersensitivity
MP:0002150	obsolete immune system: no defect detected	OBSOLETE. no anomaly observed in examination of immune system tissues or function
MP:0002151	abnormal neural tube morphology	any structural anomaly of the hollow epithelial tube found on the dorsal side of the vertebrate embryo that develops into the central nervous system (i.e. brain and spinal cord)
MP:0002152	abnormal brain morphology	any structural anomaly of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)
MP:0002156	obsolete central nervous system: no defect detected	OBSOLETE. no anomaly observed in examination of central nervous system tissues or function
MP:0002159	obsolete peripheral nervous system: no defect detected	OBSOLETE. no anomaly observed in examination of peripheral nervous system tissues or function
MP:0002160	abnormal reproductive system morphology	structural or developmental anomaly of any of the tissues involved in the reproductive system
MP:0002161	abnormal fertility/fecundity	anomaly in the reproductive capability of an organism or population to produce live offspring
MP:0002162	obsolete reproductive system: no defect detected	OBSOLETE. no anomaly observed in examination of reproductive system tissues or function
MP:0002163	abnormal gland morphology	any structural anomaly of an organ that functions as a secretory or excretory organ
MP:0002164	abnormal gland physiology	any functional anomaly of an organ that functions as a secretory or excretory organ
MP:0002165	obsolete glands: no defect detected	OBSOLETE. no anomaly observed in examination of endocrine system tissues or function
MP:0002166	abnormal tumor susceptibility	greater than or less than the average number of tumors, usually a specific type, arising in a given organism when compared to controls
MP:0002167	obsolete unaffected tumor susceptibility/resistance	OBSOLETE. average number of tumors in an organism compared to controls, usually referring to a specific tumor type
MP:0002168	obsolete other aberrant phenotype	anomaly or dysmorphology not attributable to any other category
MP:0002169	no abnormal phenotype detected	normal viability, fertility, appearance and behavior; reported phenotype is indistinguishable from controls
MP:0002174	abnormal gastrulation movements	failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers
MP:0002175	decreased brain weight	lower than average weight of the brain
MP:0002176	increased brain weight	greater than average weight of the brain
MP:0002177	abnormal outer ear morphology	any structural anomaly of any components of the auricles or external acoustic meatus
MP:0002180	obsolete	OBSOLETE.
MP:0002181	obsolete abnormal brain cell morphology	OBSOLETE. any structural anomaly of any or all brain cell types
MP:0002182	abnormal astrocyte morphology	any structural anomaly of the large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord; astrocytes are irregularly shaped with many long processes, including those with 'end feet' which form the glial (limiting) membrane and directly and indirectly contribute to the blood-brain barrier; astrocytes regulate the extracellular ionic and chemical environment, and 'reactive astrocytes' (along with microglia) respond to injury
MP:0002183	gliosis	increased growth pattern of neuroglia in a damaged area of the brain or spinal cord
MP:0002184	abnormal innervation	the malformation, misprojection, abnormal fasciculation or abnormal refinement of the connection, of nerve fibers to a target
MP:0002185	obsolete ectopia	OBSOLETE. congenital positional anomaly or displacement of any part of the body or organ
MP:0002187	abnormal fibula morphology	any structural anomaly of the lateral and smaller bone of the lower limb
MP:0002188	small heart	reduced size of the heart relative to average
MP:0002189	abnormal myocardial trabeculae morphology	any structural anomaly of the supporting bundles of muscular fibers lining the walls of the heart
MP:0002190	disorganized myocardium	derangement of the patterned architecture of the myocardium
MP:0002191	abnormal artery morphology	any structural anomaly of the blood vessels that carry blood away from the heart
MP:0002192	hydrops fetalis	an abnormal accumulation of serous fluid in fetal tissues
MP:0002193	minimal clonic seizures	seizures involving rhythmic face and forelimb clonus including arm movement, and it may include rearing and falling and ventral flexion of the neck; a seizure is scored as minimal when it satisfies the minimal criteria up to or including ventral flexion, but does not include maximal tonic hindlimb extension
MP:0002194	maximal tonic hindlimb extension seizures	seizures induced by electrical stimulation of the brainstem; manifesting as a tonic-clonic flexion/extension sequence, starting in tonic extension of the forelimbs and terminating in a full tonic hindlimb extension, which is defined when the angle of the hindlimbs to the torso exceeds 90 degrees (although it is usually 180 degrees)
MP:0002195	psychomotor seizures	low frequency, tetanic stimulation used to evoke partial limbic seizures, with currents ranging from 8 mA to 20 mA, depending on the strain and gender; manifesting as rhythmic face movements and extensive forelimb clonus (e.g. shadow-boxing forelimb movements), dorsal flexion of the neck, rearing and falling, and/or transient wobbliness/ataxia; seizure lasts only 10-15 seconds and when antiepileptic drugs are present may last only a few seconds
MP:0002196	absent corpus callosum	absence of the commissural plate interconnecting the cortical hemispheres of the brain
MP:0002199	abnormal brain commissure morphology	any structural anomaly of any of the nerve fiber tracts that span the longitudinal fissure between the cerebral and/or cerebellar hemispheres of the brain
MP:0002200	abnormal brain ventricular system morphology	any structural anomaly of the brain ventricles, their associated choroid plexuses or the intercommunicating channels that connect the ventricular system
MP:0002201	obsolete abnormal neurotransmitter receptor physiology	OBSOLETE. aberrant function of cell surface receptors that bind signaling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells
MP:0002204	abnormal synaptic neurotransmitter level	anomaly in the amount of endogenous signaling molecules in a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell
MP:0002205	obsolete neurotransmitter imbalance	OBSOLETE.
MP:0002206	abnormal CNS synaptic transmission	defect in the communication from a neuron to a target across a synapse in the central nervous system
MP:0002207	abnormal long-term potentiation	alterations in a persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells
MP:0002208	abnormal germ cell morphology	any structural anomaly of the germ cell, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated
MP:0002209	decreased germ cell number	reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated
MP:0002210	abnormal sex determination	anomaly of primary or secondary sexual development or characteristics
MP:0002211	abnormal primary sex determination	aberrant gonadal development resulting in either abnormal or absent gonads or the development of gonads inconsistent with the chromosomal sex
MP:0002212	abnormal secondary sex determination	gonadal development may or may not be normal, and the phenotype of the animal outside the gonad does not match chromosomal sex or is ambiguous
MP:0002213	true hermaphroditism	the presence of both unequivocal ovarian tissue and testicular elements in the same individual regardless of karyotype; these two tissue types may be present in the same gonad (ovotestis) or may be present as separate ovaries and testis tissue elements in the same individual regardless of sex chromosome complement
MP:0002214	streak gonad	impairment of genital ridge development; aplasia of gonadal tissue which is sometimes replaced with functionless tissue
MP:0002215	obsolete testicular feminization	OBSOLETE. an XY animal displaying female sex characteristics, usually due to an X-linked mutation
MP:0002216	abnormal seminiferous tubule morphology	any structural anomaly of the tubules in the testes where spermatogenesis occurs
MP:0002217	small lymph nodes	lymph nodes of decreased size
MP:0002218	increased lymph node number	greater than the normal number of lymph nodes
MP:0002219	decreased lymph node number	fewer than the normal number of lymph nodes
MP:0002220	large lymphoid organs	increased size of lymphatic tissues
MP:0002221	abnormal lymph organ size	change in the normal size of lymphatic tissues
MP:0002222	obsolete abnormal lymph organ cellularity	OBSOLETE. change in the normal number of cells within a lymph organ
MP:0002223	lymphoid hypoplasia	decrease in the number of normal cells in normal arrangement in the lymphoid tissue, typically resulting in decreased size
MP:0002224	abnormal spleen size	deviation from the normal spleen size
MP:0002225	obsolete abnormal spleen cellularity	OBSOLETE. anomaly in the cellular makeup of the spleen
MP:0002227	abnormal spleen capsule morphology	any structural anomaly of the connective tissue that surrounds the spleen
MP:0002228	abnormal spleen trabecular vein morphology	any structural anomaly of one of the veins that feed the splenic vein
MP:0002229	neurodegeneration	a retrogressive impairment of function or destruction of neural tissue
MP:0002230	abnormal primitive streak formation	anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm
MP:0002231	abnormal primitive streak morphology	anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm
MP:0002232	obsolete sensory capabilities	OBSOLETE.
MP:0002233	abnormal nose morphology	any structural anomaly of the organ that is specialized for smell and is part of the respiratory system
MP:0002234	abnormal pharynx morphology	any structural anomaly in the passage between the mouth and the posterior nares and the larynx and esophagus
MP:0002235	abnormal external nares morphology	any structural anomaly of the anterior opening to the nasal cavity
MP:0002236	abnormal internal nares morphology	any structural anomaly of the portion of the opening of the nasal cavity into the nasal pharynx
MP:0002237	abnormal nasal cavity morphology	any structural anomaly of the cavity of the respiratory tract that extends from the nares to the pharynx; the nasal cavity is lined with ciliated mucosa
MP:0002238	abnormal nasal mucosa morphology	any structural anomaly of the mucous membrane that lines the nasal cavity
MP:0002239	abnormal nasal septum morphology	any structural anomaly of the dividing wall that runs down the midline of the nose separating the two nasal cavities, each of which ends in a nostril; it is formed by the septal nasal cartilage, parts of skull bones (ethmoid bone; vomer), and membranous parts
MP:0002240	abnormal paranasal sinus morphology	any structural anomaly of the paired air-filled cavities surrounded by the bones of the face that are lined by mucous membranes and are continuous with the nasal cavity
MP:0002241	abnormal laryngeal mucosa goblet cell morphology	any structural anomaly of the epithelial cells lining the larynx, which produce mucins
MP:0002242	abnormal olfactory mucosa morphology	any structural anomaly of the portion of the nasal mucosa that contains the olfactory sensory endings
MP:0002243	abnormal vomeronasal organ morphology	any structural anomaly of the tubular, crescent-sensory organ with a luminal epithelium that contains chemosensitive receptor cells with microvilli that are thought to detect pheromones and transmit signals to the remainder of the accessory olfactory system; the organ lies at the base the nasal cavity and is split into two, separated by the nasal septum
MP:0002244	abnormal turbinate morphology	any structural anomaly of the small curved bones that extends horizontally along the lateral wall of the nasal passage
MP:0002245	abnormal ethmoid sinus morphology	any structural anomaly of the evaginations of the mucous membrane of the nasal cavity into the ethmoidal bony labyrinth, forming multiple small paranasal sinuses
MP:0002246	abnormal frontal sinus morphology	any structural anomaly of the paired evaginations of the mucous membrane of the nasal cavity into the lower part of the squama of the frontal bones
MP:0002247	abnormal maxillary sinus morphology	any structural anomaly of the largest of the paranasal sinuses, a paired pyramid-shaped air sinus located within the maxillary bone which drains via the maxillary ostium into the infundibulum, then through the hiatus semilunaris into the middle meatus of the nose
MP:0002248	abnormal sphenoid sinus morphology	any structural anomaly of the most posterior paranasal sinus located in the sphenoid bone near the optic nerve and the pituitary gland on the side of the skull; it drains into the sphenoethmoidal recess superior to the superior concha; the sinus is divided into right and left parts by a bony septum
MP:0002249	abnormal larynx morphology	any structural anomaly of the organ of voice production located between the pharynx and the trachea
MP:0002250	abnormal hypopharynx morphology	any structural anomaly in the portion of the pharynx that lies below the upper edge of the epiglottis and opens into the larynx and the esophagus
MP:0002251	abnormal nasopharynx morphology	any structural anomaly of the section of the pharynx that lies above the soft palate
MP:0002252	abnormal oropharynx morphology	any structural anomaly of the portion of the pharynx that lies between the soft palate and the upper edge of the epiglottis
MP:0002253	abnormal pharyngeal muscle morphology	any structural anomaly of any of the muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus
MP:0002254	reproductive system inflammation	local accumulation of fluid, plasma proteins, and leukocytes in any of the reproductive organs
MP:0002255	abnormal glottis morphology	any structural anomaly of the vocal apparatus of the larynx, which includes the vocal cords and the opening between them
MP:0002256	abnormal laryngeal cartilage morphology	any structural anomaly of the cartilaginous structures that support the larynx
MP:0002257	abnormal arytenoid cartilage morphology	any structural anomaly of the paired triangular cartilages located postlaterally at the level of the thyroid cartilage
MP:0002258	abnormal cricoid cartilage morphology	any structural anomaly of the most inferior of the laryngeal cartilages
MP:0002260	abnormal thyroid cartilage morphology	any structural anomaly of the largest of the laryngeal cartilages
MP:0002261	abnormal laryngeal mucosa morphology	any structural anomaly of the mucous lining of the larynx, which is composed of squamous epithelium in the upper larynx and ciliated columnar epithelium in the lower larynx
MP:0002262	abnormal nasal mucosa goblet cell morphology	any structural anomaly of the cells lining the nasal epithelium that produce and secrete mucins
MP:0002263	abnormal laryngeal muscle morphology	any structural anomaly of the muscles associated with the larynx
MP:0002264	abnormal bronchus morphology	any structural anomaly of the upper conducting airways of the lung; these airways arise from the terminus of the trachea
MP:0002265	abnormal left major bronchus morphology	any structural anomaly of the conducting airway leading to the left lobe of the lungs
MP:0002266	abnormal right major bronchus morphology	any structural anomaly of the conducting airway leading to the right lobe of the lungs
MP:0002267	abnormal bronchiole morphology	any structural anomaly of the conducting airway of the lungs found terminal to the bronchi; these structures contain neither cartilage nor mucous-secreting glands; the epithelium of the bronchioles becomes thinner with each branching
MP:0002268	abnormal terminal bronchiole morphology	any structural anomaly of the last conducting structure of non-respiratory bronchioles; after this point, the airways have alveoli in their walls
MP:0002269	muscular atrophy	acquired diminution of muscle tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes; occurs with age, immobilization, weightlessness, malnutrition or denervation
MP:0002270	abnormal pulmonary alveolus morphology	any structural anomaly of the small sac-like dilations of the distal airspace of the lung; they are present along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles; gas exchange of oxygen and carbon dioxide between alveolar air and blood in the pulmonary capillaries takes place across the cell walls
MP:0002271	abnormal pulmonary alveolar duct morphology	any structural anomaly of the respiratory conducting tubes distal to the respiratory bronchiole that lead to the alveolar sacs and the alveoli
MP:0002272	abnormal nervous system electrophysiology	any functional anomaly of the nervous system as it relates to conduction of electrical impulses
MP:0002273	abnormal pulmonary alveolus epithelial cell morphology	any structural anomaly of the cells lining the alveoli
MP:0002274	abnormal type I pneumocyte morphology	any structural anomaly of the flattened, branched squamous cells that covers more than 98 percent of the alveolar surface, and have thin (50-100 nm) cytoplasmic extensions to form the air-blood barrier essential for normal gas exchange
MP:0002275	abnormal type II pneumocyte morphology	any structural anomaly of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored
MP:0002276	abnormal lung interstitium morphology	any structural anomaly of the connective tissue located between the respiratory (airway and alveolar) epithelium, the capillary endothelium and pleural mesothelium; it contains basement membrane composed of collagen, elastin, proteoglycans, and fibronectin; it functions in the mechanical behavior of the lung, and forms a barrier to regulate the flow of plasma constituents from the capillaries to the airway and alveolar spaces
MP:0002277	abnormal respiratory mucosa morphology	any structural anomaly of the mucous membrane lining the respiratory tract
MP:0002278	obsolete abnormal respiratory muscle morphology	OBSOLETE. structural anomaly of any of the muscles involved in breathing
MP:0002279	abnormal diaphragm morphology	any structural anomaly of the thin musculomebranous barrier that separates the abdominal and thoracic cavities; these muscles often used for breathing control
MP:0002280	abnormal intercostal muscle morphology	any structural anomaly of the respiratory muscles that arise from the lower border of one rib and insert into the upper border of the adjoining rib
MP:0002281	abnormal respiratory mucosa goblet cell morphology	any structural anomaly of the cells of the respiratory epithelial lining that produce and secrete mucins
MP:0002282	abnormal trachea morphology	any structural anomaly of the tube descending from the larynx and branching into the right and left main bronchi
MP:0002283	obsolete hyaline cartilage abnormalities	OBSOLETE.
MP:0002284	abnormal tracheal smooth muscle morphology	any structural anomaly of the smooth muscle lining the trachea
MP:0002285	abnormal tracheal ciliated epithelium morphology	any structural anomaly of the epithelial lining of the trachea which contains numerous ciliated cells
MP:0002286	cryptorchism	failure of one or both of the testes to descend into the scrotum around the time of birth
MP:0002287	obsolete reproductive system: fertility/fecundity characteristics	OBSOLETE.
MP:0002288	obsolete litter size	OBSOLETE.
MP:0002291	obsolete fecundity characteristics	OBSOLETE.
MP:0002292	abnormal gestational length	anomaly in the usual duration of time between when a fertilized egg implants in the wall of the uterus and the birth of offspring
MP:0002293	long gestation period	increase in the average duration of a pregnancy
MP:0002294	short gestation period	decrease in the average duration of a pregnancy
MP:0002295	abnormal pulmonary circulation	any anomaly in the circulation of blood through the lungs
MP:0002296	aspiration	inspiration into the airways of fluid or any foreign material
MP:0002297	abnormal forced expiratory flow rates	anomaly in the rates of airflow during forced vital capacity determination
MP:0002298	obsolete abnormal maximal expiratory flow rate	OBSOLETE.
MP:0002299	obsolete abnormal maximal expiratory flow-volume curve	OBSOLETE.
MP:0002300	obsolete abnormal maximal midexpiratory flow rate	OBSOLETE.
MP:0002301	obsolete abnormal peak expiratory flow rate	OBSOLETE.
MP:0002302	obsolete abnormal forced expiratory volume	OBSOLETE. anomaly in the maximum amount of air that can be expelled in a given number of seconds during a forced vital capacity determination
MP:0002303	obsolete abnormal maximal voluntary ventilation	OBSOLETE. anomaly in the maximum amount of air that can be breathed in and blown out over a specified interval
MP:0002304	abnormal total lung capacity	anomaly in the volume of air contained in the lungs at the end of maximal inspiration
MP:0002305	obsolete abnormal closing volume	OBSOLETE.
MP:0002306	abnormal functional residual capacity	anomaly in the volume of air remaining in the lungs at the end of a normal expiration
MP:0002307	obsolete abnormal expiratory reserve volume	OBSOLETE. anomaly in the amount of the extra volume of air that can be expired with maximum effort beyond the level reached at the end of a normal expiration
MP:0002308	abnormal residual volume	anomaly in the volume of air remaining in the lungs at the end of maximal expiration
MP:0002309	abnormal vital capacity	anomaly in the amount of air that is exhaled by a maximal expiration following a maximal inspiration
MP:0002310	decreased susceptibility to hepatic steatosis	less likely than normal to develop hepatic steatosis
MP:0002311	abnormal inspiratory capacity	anomaly in the maximal volume of air that can be inspired after the end of a normal expiration
MP:0002312	abnormal inspiratory reserve volume	anomaly in the extra volume of air that can be inspired with maximal effort after reaching the end of a normal inspiration
MP:0002313	abnormal tidal volume	anomaly in the volume of air inspired or expired during each normal respiratory cycle
MP:0002314	abnormal respiratory mechanics	anomaly in the action of the lungs, diaphragm, ribs and chest wall during respiration
MP:0002315	obsolete abnormal respiratory signs/symptoms	OBSOLETE. manifestations of diseases of the respiratory tract
MP:0002316	anoxia	absence or almost complete absence of oxygen from inspired gases, in blood or tissues
MP:0002318	hypercapnia	elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases
MP:0002319	hyperoxia	elevated concentration of O2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases
MP:0002320	hyperventilation	a state in which there is a increased amount of air entering the pulmonary alveoli (increased alveolar ventilation), which causes an decrease in arterial carbon dioxide level
MP:0002321	hypoventilation	a state in which there is a reduced amount of air entering the pulmonary alveoli (decreased alveolar ventilation), which causes an increase in arterial carbon dioxide level
MP:0002322	abnormal respiratory transport	anomaly in the process of gas exchange
MP:0002323	decreased susceptibility to hyperlipidemia	less likely than normal to develop abnormally high levels of circulating lipids
MP:0002324	abnormal alveolocapillary membrane morphology	any structural anomaly of the membrane between the capillary blood and alveolar air, comprised of the alveolar epithelium and the capillary epithelium and their adherent basement membranes and epithelial cell cytoplasm
MP:0002325	abnormal pulmonary diffusing capacity	anomaly in the amount of gas taken up by pulmonary capillary blood per minute per unit of average oxygen pressure gradient between alveolar gas and pulmonary capillary blood
MP:0002326	abnormal ventilation-perfusion ratio	anomaly in the ratio of alveolar ventilation to simultaneous capillary blood flow in the lung
MP:0002327	abnormal respiratory function	anomaly in any measure of the processes involved in respiration
MP:0002328	abnormal airway resistance	anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow
MP:0002329	abnormal blood gas level	anomaly in the amount of oxygen and carbon dioxide in the blood
MP:0002330	abnormal bronchial provocation	anomaly in the results of measures of responsiveness to allergens, pharmacological solutions, or control solutions
MP:0002332	abnormal exercise endurance	improved or impaired performance during controlled physical activity
MP:0002333	abnormal lung compliance	anomaly in the ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure
MP:0002334	abnormal airway responsiveness	anomalous response in bronchial provocation tests
MP:0002335	decreased airway responsiveness	less easily provoked into bronchoconstriction during bronchial provocation testing
MP:0002336	abnormal pulmonary gas exchange	anomaly in the exchange of oxygen and carbon dioxide between the alveolar air and pulmonary capillary blood
MP:0002337	abnormal whole-body plethysmography	anomaly in the measurements gathered in a chamber that encloses the body and in which changes in volume are recorded
MP:0002338	abnormal pulmonary ventilation	anomaly of the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment
MP:0002339	abnormal lymph node morphology	any structural anomaly of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue, and is the site where acquired immune responses are launched
MP:0002340	abnormal axillary lymph node morphology	any structural anomaly of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region
MP:0002341	obsolete abnormal lymph node capsule	OBSOLETE. anomaly in the connective tissue that surrounds a lymph node
MP:0002342	abnormal lymph node trabecula morphology	any structural anomaly of the membranous processes on the internal surface of the lymph node capsule, consisting of connective tissue and muscle fibers
MP:0002343	abnormal lymph node cortex morphology	any structural anomaly in the outer area of the lymph node that has B and T cell domains
MP:0002344	abnormal lymph node B cell domain morphology	any structural anomaly of the part of the lymph node cortex in which B lymphocytes home to primary follicles to survey follicular dendritic cells (FDCs); antigen stimulated B cells proliferate and differentiate within the follicles forming distinctive germinal centers
MP:0002345	abnormal lymph node primary follicle morphology	any structural anomaly of an unstimulated network of follicular dendritic cells and small resting B cells in the lymph node cortex
MP:0002346	abnormal lymph node secondary follicle morphology	any structural anomaly of a lymph node primary follicle that has undergone antigenic challenge and is characterized by a ring of concentrically packed B lymphocytes surrounding a germinal center, which contains proliferating B cells, and a mantle area that contains nondividing B cells and some helper T cells with macrophages and follicular dendritic cells interspersed
MP:0002347	abnormal lymph node T cell domain morphology	any structural anomaly of the paracortex and interfollicular cortex of the lymph node in which T lymphocytes home to survey dendritic cells; T lymphocytes proliferate in the paracortex and enlarge it but do not produce structures analogous to germinal centers
MP:0002348	abnormal lymph node medulla morphology	any structural anomaly in the area of the lymph node through which lymph leaves the node; it contains macrophages and antibody-secreting plasma cells
MP:0002349	abnormal afferent lymphatic vessel morphology	any structural anomaly in the lymphatic tubes entering the lymph node
MP:0002350	abnormal efferent lymphatic vessel morphology	any structural anomaly in the lymphatic tube exiting the lymph node
MP:0002351	abnormal cervical lymph node morphology	any structural anomaly of the lymph nodes found near the neck and shoulders
MP:0002352	abnormal popliteal lymph node morphology	any structural anomaly of the lymph nodes which drain the legs
MP:0002353	abnormal inguinal lymph node morphology	any structural anomaly of the lymph nodes located in the groin area
MP:0002354	abnormal spleen trabecular artery morphology	any structural anomaly of one of the branches of the splenic artery
MP:0002355	obsolete abnormal spleen venous sinus	OBSOLETE.
MP:0002356	abnormal spleen red pulp morphology	any structural anomaly of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation
MP:0002357	abnormal spleen white pulp morphology	any structural anomaly of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
MP:0002358	abnormal spleen periarteriolar lymphoid sheath morphology	any structural anomaly of the area of the spleen in which T cells surround the central arteriole
MP:0002359	abnormal spleen germinal center morphology	any structural anomaly of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0002360	abnormal spleen B cell corona morphology	any structural anomaly of the area of the spleen secondary B follicle that surrounds the germinal center and harbors the small recirculating B lymphocytes
MP:0002361	abnormal spleen central arteriole morphology	any structural anomaly of the blood vessel surrounded by the periarteriolar lymphoid sheath that connects the trabecular artery to the trabecular vein
MP:0002362	abnormal spleen marginal zone morphology	any structural anomaly of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens
MP:0002363	abnormal spleen marginal sinus morphology	any structural anomaly of the border region surrounding the spleen B cell follicles and the periarteriolar lymphoid sheath (PALS) that separates it from the marginal zone that mediates lymphocyte entry into the white pulp from the blood
MP:0002364	abnormal thymus size	deviation from the normal size of the thymus
MP:0002365	obsolete abnormal thymus cellularity	OBSOLETE. anomaly in the cellular makeup of the thymus
MP:0002367	abnormal thymus lobule morphology	any structural anomaly of the basic structural unit of the thymus
MP:0002368	abnormal thymus capsule morphology	any structural anomaly of the fibrous connective tissue surrounding the thymus
MP:0002369	abnormal thymus subcapsular epithelium morphology	any structural anomaly of the epithelial cells lining the capsule and trabeculae of the thymus
MP:0002370	abnormal thymus trabecula morphology	any structural anomaly of the thymic connective tissue which extends into the parenchyma
MP:0002371	abnormal thymus cortex morphology	any structural anomaly of the outer part of a thymus lobule that surrounds the medulla and is composed of closely packed lymphocytes
MP:0002373	obsolete abnormal macrophages in the thymus	OBSOLETE.
MP:0002374	obsolete abnormal thymus epithelial cells	OBSOLETE.
MP:0002375	abnormal thymus medulla morphology	any structural anomaly of the inner area of thymus lobules
MP:0002376	abnormal dendritic cell physiology	any functional anomaly of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity
MP:0002377	abnormal mucosa-associated lymphoid tissue morphology	any structural anomaly of the regional immune system associated with the mucosa
MP:0002378	abnormal gut-associated lymphoid tissue morphology	any structural anomaly of the regional immune system located in the gut
MP:0002379	abnormal oropharyngeal lymphoid tissue morphology	any structural anomaly of the circular lymphoid tissue formed by the lingual, pharyngeal, and facial tonsils
MP:0002380	abnormal palatine tonsil morphology	any structural anomaly of either of the two small almond-shaped masses of lymph tissue found on either side of the oropharynx
MP:0002381	obsolete abnormal tonsil capsule	OBSOLETE.
MP:0002382	obsolete abnormal lymphatic nodules with germinal centers	OBSOLETE.
MP:0002383	obsolete abnormal tonsil crypts	OBSOLETE.
MP:0002384	abnormal nasopharyngeal tonsil morphology	any structural anomaly of the lymph tissue in the roof and posterior wall of the nasopharynx
MP:0002385	abnormal lingual tonsillar tissue morphology	any structural anomaly of the lymph tissue on the floor of the oropharyngeal passage, near the root of the tongue
MP:0002386	abnormal tubal tonsil morphology	any structural anomaly of the lymph tissue associated with the pharyngeal opening of the auditory tube
MP:0002387	obsolete abnormal prevalence of Peyer's patches	OBSOLETE. deviation from the normal distribution and/or number of Peyer's patches
MP:0002388	abnormal Peyer's patch epithelium morphology	any structural anomaly of the specialized epithelium of the Peyer's patch
MP:0002389	abnormal Peyer's patch follicle morphology	any structural anomaly of the area of the Peyer's patch normally occupied by B cells
MP:0002390	obsolete abnormal Peyer's patch dome	OBSOLETE.
MP:0002391	abnormal Peyer's patch germinal center morphology	any structural anomaly of the area of the Peyer's patch where B cells proliferate and differentiate into plasma cells
MP:0002392	abnormal Peyer's patch T cell area morphology	any structural anomaly of the Peyer's patch area normally occupied by T lymphocytes
MP:0002393	abnormal bronchus-associated lymphoid tissue morphology	any structural anomaly of the regional immune system located near the bronchus
MP:0002394	obsolete absent thymocyte subset	OBSOLETE. lack of a particular group of T cells
MP:0002395	obsolete hemolymphoid system abnormalities	OBSOLETE. anomalies of the blood and blood-forming tissues or of the immune system and immune cell forming tissues
MP:0002396	abnormal hematopoietic system morphology/development	any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells
MP:0002397	abnormal bone marrow morphology	any structural anomaly of the soft tissue that fills the cavities of bones
MP:0002398	abnormal bone marrow cell morphology/development	any structural anomaly of the cells found in the bone marrow
MP:0002399	abnormal pluripotent precursor cell morphology	any structural anomaly of the cells that give rise to most types of cells necessary for fetal development
MP:0002400	abnormal multipotent stem cell morphology	any structural anomaly of the specialized cells that are committed to giving rise to cells with particular functions
MP:0002401	abnormal lymphopoiesis	atypical formation of lymphocytes and plasma cells from lymphoid stem cells which develop from the pluripotent hematopoietic stem cells in the bone marrow; lymphoid stem cells differentiate into T-lymphocytes; B-lymphocytes; plasma cells; or NK-cells (natural killer cells), depending on the organ or tissues to which they migrate
MP:0002403	abnormal pre-B cell morphology	any structural anomaly of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface
MP:0002404	increased intestinal adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the small and/or large intestine, occurring in a specific population in a given time period
MP:0002405	respiratory system inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system
MP:0002406	increased susceptibility to infection	greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens
MP:0002407	abnormal double-negative T cell morphology	any structural anomaly of the subset of T cells found in the thymus that express neither CD4 nor CD8
MP:0002408	abnormal double-positive T cell morphology	any anomaly of the subset of T cells found in the thymus that express both CD4 and CD8
MP:0002409	decreased susceptibility to infection	reduced likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens
MP:0002410	decreased susceptibility to viral infection	reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus
MP:0002411	decreased susceptibility to bacterial infection	reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria
MP:0002412	increased susceptibility to bacterial infection	greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria
MP:0002413	abnormal megakaryocyte progenitor cell morphology	any structural anomaly of the progenitor cells of the thrombocytic (platelet) line of cells
MP:0002414	abnormal myeloblast morphology/development	any structural anomaly of the cells found in the bone marrow that give rise to the granulocyte line of blood cells
MP:0002415	abnormal neutrophil differentiation	atypical production of or inability to produce the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes
MP:0002416	abnormal proerythroblast morphology	any structural anomaly of the immature, nucleated erythrocyte precursors that give rise to reticulocytes and are derived from erythroid progenitor cells
MP:0002417	abnormal megakaryocyte morphology	any structural anomaly of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm
MP:0002418	increased susceptibility to viral infection	greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus
MP:0002419	abnormal innate immunity	anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens
MP:0002420	abnormal adaptive immunity	anomaly in the function of the response of antigen-specific lymphocytes to antigen, including the development of immunological memory
MP:0002421	abnormal cell-mediated immunity	abnormal function of any adaptive immune response in which T cells play a main role
MP:0002422	abnormal basophil morphology	any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has an irregularly shaped, pale-staining nucleus that is partially constricted into two lobes, and with cytoplasm that contains coarse, bluish-black granules of variable size; these cells contain vasoactive amines such as histamine and serotonin, which are released on appropriate stimulation
MP:0002423	abnormal mast cell physiology	any functional anomaly of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules
MP:0002424	abnormal reticulocyte morphology	any structural anomaly of immature erythrocytes characterized by a meshlike pattern of threads and particles at the former site of the nucleus
MP:0002425	abnormal susceptibility to autoimmune disorder	a change in the likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides
MP:0002426	obsolete blood abnormalities	OBSOLETE. structural anomalies in the cells, fluids, or proteins found in the blood
MP:0002427	disproportionate dwarf	abnormally undersized with disproportionate body parts; usually with more significant shortening of the limbs in proportion to the trunk size
MP:0002428	abnormal semicircular canal morphology	any structural anomaly of the organ of balance composed of three long bony tubes of the labyrinth
MP:0002429	abnormal blood cell morphology/development	any structural anomaly of any of the cells found in the blood or hematopoietic organ
MP:0002432	abnormal CD4-positive, alpha beta T cell morphology	any structural anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0002433	abnormal T-helper 1 cell morphology	any structural anomaly of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0002434	abnormal T-helper 2 cell morphology	any structural anomaly of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0002435	abnormal effector T cell morphology	any structural anomaly of a differentiated T cell with ability to traffic to peripheral tissues and is capable of mounting a specific immune response
MP:0002436	abnormal CD8-positive, alpha-beta cytotoxic T cell morphology	any structural anomaly of a CD8-positive, alpha-beta T cell capable of killing target cells in an antigen specific manner
MP:0002439	abnormal plasma cell morphology	any structural anomaly of a terminally differentiated, post-mitotic, short-lived cell of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0002440	abnormal memory B cell morphology	any structural anomaly of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin
MP:0002441	abnormal granulocyte morphology	any structural anomaly of leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils
MP:0002442	abnormal leukocyte physiology	any functional anomaly of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes)
MP:0002443	abnormal eosinophil differentiation	atypical production of or inability to produce the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions
MP:0002444	abnormal T cell physiology	any functional anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation
MP:0002445	abnormal mononuclear cell differentiation	atypical production of or inability to produce a leukocyte with a single non-segmented nucleus in the mature form
MP:0002446	abnormal macrophage morphology	any structural anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
MP:0002447	abnormal erythrocyte morphology	any structural anomaly of a mature red blood cell, an ennucleate biconcave disk about 7 micrometers in diameter that contains hemoglobin confined within a lipid membrane; it is the major cellular element of the circulating blood and transports oxygen as its principal function
MP:0002450	abnormal lymph organ development	anomaly in the process of morphological maturation of the organs of the lymph system
MP:0002451	abnormal macrophage physiology	any functional anomaly of the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
MP:0002452	abnormal professional antigen presenting cell physiology	any functional anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response
MP:0002453	abnormal B lymphocyte antigen presentation	anomaly in the ability of B lymphocyte to process and/or present antigen
MP:0002454	abnormal macrophage antigen presentation	anomaly in the ability of macrophage phagocytic cells to process and present antigen to T lymphocytes
MP:0002455	abnormal dendritic cell antigen presentation	anomaly in the ability of dendritic cells to process and present antigen to T lymphocytes
MP:0002456	abnormal Langerhans cell antigen presentation	anomaly in the ability of phagocytic cells of the epidermis to display antigen for recognition by T lymphocytes
MP:0002458	abnormal B cell number	deviation from the normal count of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity
MP:0002459	abnormal B cell physiology	any functional anomaly of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
MP:0002460	decreased immunoglobulin level	less than normal immunoglobulin level
MP:0002461	increased immunoglobulin level	greater than normal immunoglobulin level
MP:0002462	abnormal granulocyte physiology	any functional anomaly of neutrophils, eosinophils, or basophils
MP:0002463	abnormal neutrophil physiology	abnormal function of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes
MP:0002464	abnormal basophil physiology	any functional anomaly of the leukocyte that contains granules that stain with basic dyes
MP:0002465	abnormal eosinophil physiology	any functional anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions
MP:0002467	impaired neutrophil phagocytosis	reduced ability of neutrophils to internalize particulate matter
MP:0002468	obsolete abnormal complement physiology	OBSOLETE. abnormal function of the set of plasma proteins that act together to attack extracellular pathogens
MP:0002469	obsolete abnormal C1 physiology	OBSOLETE. abnormal function of the complement protein, C1
MP:0002470	obsolete abnormal C2 physiology	OBSOLETE. abnormal function of the complement protein, C2
MP:0002471	abnormal complement pathway	impaired ability of the complement proteins to act sequentially to directly kill microbes, dispose of immune complexes, and regulate other immune processes
MP:0002472	impaired complement alternative pathway	abnormal function of the plasma protein cascade triggered by direct contact with pathogen surfaces
MP:0002473	impaired complement classical pathway	abnormal function of the plasma protein cascade triggered by antigen:antibody complexes
MP:0002474	obsolete abnormal C3 physiology	OBSOLETE. abnormal function of the complement protein, C3
MP:0002475	obsolete abnormal C4 physiology	OBSOLETE. abnormal function of the complement protein, C4
MP:0002476	obsolete abnormal C5 physiology	OBSOLETE. abnormal function of the complement protein, C5
MP:0002477	obsolete abnormal C6 physiology	OBSOLETE. abnormal function of the complement protein, C6
MP:0002478	obsolete abnormal C7 physiology	OBSOLETE. abnormal function of the complement protein, C7
MP:0002479	obsolete abnormal C8 physiology	OBSOLETE. abnormal function of the complement protein, C8
MP:0002480	obsolete abnormal C9 physiology	OBSOLETE. abnormal function of the complement protein, C9
MP:0002481	obsolete abnormal factor B physiology	OBSOLETE. abnormal function of the complement protein, factor B
MP:0002482	obsolete abnormal factor D physiology	OBSOLETE. abnormal function of the complement protein, factor D
MP:0002483	obsolete abnormal acute phase protein physiology	OBSOLETE. functional anomaly in the series of proteins found in the blood shortly after infection and which participate in the early phases of host defense against infection
MP:0002484	obsolete abnormal C-reactive protein physiology	OBSOLETE. anomaly in the function of this plasma protein that normally circulates in increased amounts during inflammation or after tissue damage
MP:0002485	obsolete abnormal mannose-binding protein physiology	OBSOLETE. an anomaly in the function of this acute phase protein that normally opsonizes pathogens bearing mannose on their surfaces and can activate the complement system
MP:0002486	obsolete abnormal serum amyloid protein physiology	OBSOLETE. any functional anomaly in an acute-phase reaction protein that is a precursor to amyloid A protein; it is present in very high levels during acute inflammatory episodes, and is present in low concentrations in normal sera, but is found at higher concentrations in sera of older persons and in patients with amyloidosis
MP:0002487	obsolete abnormal fibrinogen physiology	OBSOLETE. an anomaly in the function of this coaguable protein in the blood plasma
MP:0002488	obsolete abnormal phagocyte physiology	OBSOLETE. anomaly in the ability of these cells to ingest and internalize particulate matter
MP:0002490	abnormal immunoglobulin level	deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies
MP:0002491	decreased IgD level	less than normal immunoglobulin class D level
MP:0002492	decreased IgE level	less than normal immunoglobulin class E level
MP:0002493	increased IgG level	greater than normal immunoglobulin class G level
MP:0002494	increased IgM level	greater than normal immunoglobulin class M level
MP:0002495	increased IgA level	greater than normal immunoglobulin class A level
MP:0002496	increased IgD level	greater than normal immunoglobulin class D level
MP:0002497	increased IgE level	greater than normal immunoglobulin class E level
MP:0002498	abnormal acute inflammation	aberrant early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response
MP:0002499	chronic inflammation	persistent inflammatory response, often caused by persistent infection or during an autoimmune response
MP:0002500	granulomatous inflammation	chronic inflammation resulting from the failure of the acute inflammatory response and persistence of the injurious agent; characterized by a central area of macrophages, often fused into giant cells, and surrounded by T cells
MP:0002501	obsolete abnormal inflammatory mediator physiology	OBSOLETE. functional anomaly of any of the endogenous compounds that mediate the local accumulation of fluid, plasma proteins, and leukocytes at the site of injury, insult, or infection
MP:0002502	obsolete abnormal vasoactive mediator physiology	OBSOLETE. functional anomaly of any of the endogenous compounds that act on the vasculature
MP:0002503	abnormal histamine physiology	any functional anomaly of this amine that is involved in local immune response, in regulating physiological function in the gut, and that acts as a neurotransmitter
MP:0002504	obsolete abnormal serotonin physiology	OBSOLETE. functional anomaly of this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets; it normally mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
MP:0002505	obsolete abnormal bradykinin physiology	OBSOLETE. functional anomaly of this potent, short-lived vasoactive peptide that causes arteriolar dilation and increased capillary permeability
MP:0002506	obsolete abnormal anaphylotoxin physiology	OBSOLETE. functional anomaly of any of the small fragments of complement proteins released by cleavage during complement activation, they are chemotactic and vasoactive
MP:0002507	obsolete abnormal C4a physiology	OBSOLETE. functional anomaly of complement fragment C4a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction
MP:0002508	obsolete abnormal complement 5a physiology	OBSOLETE. functional anomaly of this product of complement activation that is a potent chemotactic factor for neutrophils, monocytes, and basophils and enhances smooth muscle contraction and vascular permeability
MP:0002509	obsolete abnormal C3a physiology	OBSOLETE. functional anomaly of complement fragment C3a, which is normally involved in increasing vascular permeability and enhancing smooth muscle contraction
MP:0002510	obsolete abnormal leukotriene physiology	OBSOLETE. functional anomaly of any of a family of mediators derived from arachidonic acid which normally stimulate smooth muscle contraction, increase vascular permeability, and may be chemoattractants for inflammatory cells
MP:0002511	obsolete abnormal leukotriene C4 physiology	OBSOLETE. any functional anomaly of the conjugation product of leukotriene a4 and glutathione; it is the major arachidonic acid metabolite in macrophages and mast cells as well as in antigen-sensitized lung tissue, and it normally stimulates mucus secretion in the lung, and produces contractions of nonvascular and some vascular smooth muscle
MP:0002512	obsolete abnormal leukotriene D4 physiology	OBSOLETE. any functional anomaly of a leukotriene c4 derivative generated after partial hydrolysis of the gamma-glutamyl portion of the peptide chain; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability
MP:0002513	obsolete abnormal leukotriene E4 physiology	OBSOLETE. any functional anomaly of a leukotriene d4 derivative generated by a peptidase reaction that removes the glycine residue; its biological actions normally include stimulation of vascular and nonvascular smooth muscle, and increases in vascular permeability
MP:0002514	obsolete abnormal prostaglandin physiology	OBSOLETE. functional anomaly of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation
MP:0002515	obsolete PGD2	OBSOLETE.
MP:0002516	obsolete abnormal PGE2 physiology	OBSOLETE. functional anomaly of this member of the prostaglandin family, which normally has vasodilatory effects, increasing vascular permeability
MP:0002517	obsolete abnormal PGI2 physiology	OBSOLETE. functional anomaly of this member of the prostaglandin family that normally has vasodilatory effects, increasing vascular permeability
MP:0002518	obsolete abnormal PGF2alpha physiology	OBSOLETE. functional anomaly of this prostaglandin that normally has vasocontractile, oxytocic, luteolytic, and abortifacient activities
MP:0002519	obsolete abnormal thromboxane physiology	OBSOLETE. functional anomaly of any of the members of a family of mediators with vasoactive effects
MP:0002520	obsolete abnormal TxA2 physiology	OBSOLETE. functional anomaly of this potent vasoconstrictor that also mediates platelet aggregation
MP:0002521	obsolete abnormal platelet activating factor physiology	OBSOLETE. functional anomaly of this mediator generated by nearly all activated inflammatory cells, endothelial cells, and injured tissue cells; normally it is a potent vasodilator and enhances microvasculature permeability, in addition, it induces platelet aggregation and degranulation at sites of injury and enhances the release of serotonin
MP:0002522	obsolete abnormal chemotactic factor physiology	OBSOLETE. functional anomaly of any of a class of pro-inflammatory proteins that attract and activate leukocytes
MP:0002523	obsolete abnormal chemotactic complement factor physiology	OBSOLETE. functional anomaly of any of a subset of complement fragments that are involved in recruitment of leukocytes to the site of injury
MP:0002524	obsolete lipoxygenase products	OBSOLETE.
MP:0002525	obsolete abnormal leukotriene B4 physiology	OBSOLETE. functional anomaly of this product of inflammatory cell activation that is a potent chemoattractant for macrophages and neutrophils
MP:0002526	obsolete abnormal chemokine physiology	OBSOLETE. functional anomaly of any of the class of pro-inflammatory cytokines that attract and activate leukocytes
MP:0002527	obsolete abnormal interleukin-8 physiology	OBSOLETE. functional anomaly of this protein secreted by macrophages and is chemotactic for neutrophils and T cells
MP:0002528	obsolete abnormal interleukin-1 physiology	OBSOLETE. functional anomaly of this soluble factor produced by macrophages/monocytes that activates vascular endothelium and lymphocytes
MP:0002529	obsolete abnormal interleukin physiology	OBSOLETE. functional anomaly of any of the cytokines produced by leukocytes
MP:0002530	obsolete abnormal tumor necrosis factor physiology	OBSOLETE. functional anomaly of this cytokine produced by macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0002531	abnormal type I hypersensitivity reaction	anomaly in a reaction manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks
MP:0002532	abnormal type II hypersensitivity reaction	anomaly in the response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved
MP:0002533	abnormal type III hypersensitivity reaction	anomaly in the tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
MP:0002534	abnormal type IV hypersensitivity reaction	anomaly in an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact
MP:0002535	obsolete combined T cell/ B cell deficiency	OBSOLETE.  Use cell-mediated immunity instead.  defective or absent host defense involving both B and T cells
MP:0002536	obsolete severe combined immunodeficiency disease	OBSOLETE. rare congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels
MP:0002538	obsolete Di George syndrome	OBSOLETE. congenital syndrome with absence of thymus and parathyroids, causing impaired cellular immunity; immunoglobulin levels are normal
MP:0002539	obsolete B cell deficiency	OBSOLETE. defective or absent host defense involving B cells
MP:0002540	obsolete congenital X-linked infantile hypogammaglobulinemia	OBSOLETE. an immunologic deficiency state characterized by very low level of generally all classes of gamma-immunoglobulins
MP:0002541	obsolete selective IgA deficiency	OBSOLETE. an immunologic deficiency state characterized by very low levels of the immunoglobulin class A
MP:0002543	brachyphalangia	abnormally short phalanges
MP:0002544	brachydactyly	abnormally short digits
MP:0002546	mydriasis	increased diameter of one or both central circular aperture of the iris through which light rays enter the eye
MP:0002551	abnormal blood coagulation	altered ability or inability of the blood to clot
MP:0002552	obsolete abnormal response to addictive substance	OBSOLETE. aberrant behavioral or physiological reaction to an addictive substance
MP:0002553	preference for addictive substance	strong predilection for an addictive substance
MP:0002554	aversion to addictive substance	purposeful avoidance of an addictive substance due to dislike
MP:0002555	addiction	strong dependence on an addictive compound such as alcohol or narcotics that results in uncontrollable cravings for such compounds
MP:0002556	abnormal cocaine consumption	aberrant behavioral-related or physiological-related intake of cocaine into the body
MP:0002557	abnormal social/conspecific interaction behavior	deviation of the normal behavior of animals towards each other
MP:0002558	obsolete abnormal circadian period	any change in the cycle length expressed when exposed to constant conditions without temporal cues
MP:0002559	obsolete abnormal circadian persistence	anomaly in the ability for an animal to retain a circadian rhythm when time cues are removed
MP:0002560	obsolete arrhythmic circadian persistence	loss of any rhythmic pattern upon removal of time cues
MP:0002561	obsolete abnormal circadian phase	anomaly in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)
MP:0002562	obsolete prolonged circadian period	increase in the cycle length expressed when exposed to constant conditions without temporal cues
MP:0002563	obsolete shortened circadian period	decrease in the cycle length expressed when exposed to constant conditions without temporal cues
MP:0002564	obsolete advanced circadian phase	increase in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)
MP:0002565	obsolete delayed circadian phase	decrease in the phase relationship between a temporal synchronizing event (such as light cycle) and a phase reference point of an animal (such as activity onset)
MP:0002566	abnormal sexual interaction	altered initiation, failure of initiation or incomplete mating behavior
MP:0002567	obsolete abnormal odor preference	OBSOLETE.
MP:0002568	obsolete addiction/drug abuse	OBSOLETE.
MP:0002570	alcohol aversion	purposeful avoidance of alcohol due to dislike
MP:0002571	senility	a degenerative state of brain function manifesting in an impairment of memory, judgment, attention span, problem solving skills, the inability to perform previously learned skills that cannot be attributed to deficits of motor or sensory function, and a global loss of cognitive abilities
MP:0002572	abnormal emotion/affect behavior	altered response in tests for emotional related behaviors
MP:0002573	behavioral despair	depression assayed by reduced escape attempts and/or immobility when placed in a stressful situation such as a forced swim test or a suspension test; or failure to seek pleasurable stimuli
MP:0002574	increased vertical activity	greater than average time spent jumping or rearing
MP:0002575	increased circulating ketone body level	greater than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
MP:0002576	abnormal enamel morphology	any structural anomaly of the hard outer coating of the exposed portion of the tooth
MP:0002577	reduced enamel thickness	thin hard coating of the exposed portion of the tooth
MP:0002578	impaired ability to fire action potentials	anomaly resulting in reduced changes in membrane potentials occurring in nerve or other excitable tissue when excitation occurs
MP:0002579	disorganized secondary lens fibers	deformation or misalignment of the elongated cells that form the crystalline lens
MP:0002580	duodenal lesions	focal pathological changes characterized by alteration in the size, shape and organization of the cellular components of the duodenum epithelium tissue
MP:0002581	abnormal ileum morphology	any structural anomaly of the portion of the small intestine that extends from the jejunum to the colon
MP:0002582	disorganized extraembryonic tissue	a lack of the regular arrangement of the membranes involved with the embryo's protection and nutrition
MP:0002583	absent extraembryonic ectoderm	absence of the endoderm layer of the extraembryonic tissue
MP:0002584	small ectoplacental cone	reduced size of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta
MP:0002585	obsolete abnormal response/metabolism to xenobiotics	OBSOLETE. altered ability or inability to metabolize or respond to foreign substances
MP:0002586	abnormal platelet volume	anomaly in the content of platelet cells over normal
MP:0002587	obsolete heart/cardiovascular system: characteristics	OBSOLETE.
MP:0002588	obsolete blood cell characteristics	OBSOLETE.
MP:0002589	obsolete mean corpuscular volume traits	OBSOLETE.
MP:0002590	increased mean corpuscular volume	greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices
MP:0002591	decreased mean corpuscular volume	less than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices
MP:0002592	obsolete mean erythrocyte count traits	OBSOLETE.
MP:0002593	high mean erythrocyte cell number	greater than average numbers of red blood cells
MP:0002594	low mean erythrocyte cell number	less than average numbers of red blood cells
MP:0002596	abnormal hematocrit	greater or less than the average percentage of a volume of a blood sample occupied by red blood cells
MP:0002597	obsolete platelet traits	OBSOLETE.
MP:0002598	obsolete mean platelet volume traits	OBSOLETE.
MP:0002599	increased mean platelet volume	increased average content of platelet cells over normal
MP:0002600	obsolete mean leukocyte count traits	OBSOLETE.
MP:0002601	obsolete lymphocyte count traits	OBSOLETE.
MP:0002602	abnormal eosinophil cell number	deviation from the normal numbers of eosinophils
MP:0002603	obsolete basophil count traits	OBSOLETE.
MP:0002604	obsolete neutrophil count traits	OBSOLETE.
MP:0002605	obsolete monocyte count traits	OBSOLETE.
MP:0002606	increased basophil cell number	higher than average number of basophils as measured by the percent of the total number of leukocytes
MP:0002607	decreased basophil cell number	lower than average number of basophils as measured by the percent of the total number of leukocytes
MP:0002608	increased hematocrit	greater than average percentage of a volume of a blood sample occupied by red blood cells
MP:0002609	obsolete blood physiology traits	OBSOLETE.
MP:0002610	obsolete blood chemistry traits	OBSOLETE.
MP:0002611	obsolete glucose homeostasis traits	OBSOLETE.
MP:0002614	obsolete lipid homeostasis traits	OBSOLETE.
MP:0002619	abnormal lymphocyte morphology	any structural anomaly of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
MP:0002620	abnormal monocyte morphology	any structural anomaly of the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood
MP:0002621	delayed neural tube closure	delay in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline
MP:0002622	abnormal cochlear hair cell morphology	any structural anomaly of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve
MP:0002623	abnormal vestibular hair cell morphology	any structural anomaly of the mechanoreceptor cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear; afferent and efferent nerve fibers of the vestibular nerve end synaptically on them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the statoconial membrane of the maculae and the cupula of the cristae
MP:0002624	abnormal tricuspid valve morphology	any structural anomaly of the valve that is located between the right atrium and the right ventricle of the heart, and contains three cusps, the anterior cusp (infundibular cusp), the posterior cusp (marginal cusp), and the septal cusp (medial cusp), attached to the outer fibrous ring (annulus)
MP:0002625	heart left ventricle hypertrophy	enlargement of heart left ventricular wall from the increase in size of its cells
MP:0002626	increased heart rate	greater than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
MP:0002627	increased teratoma incidence	higher than normal incidence of generally benign germ cell-derived tumors of male or female containing derivatives from all three germ layers with differentiation in the malignant form being poor; malignant tumors are highly metatstatic
MP:0002628	hepatic steatosis	an accumulation of fat deposits in the liver
MP:0002629	hyperactivity elicited by ethanol administration	increased activity after ingestion of alcohol
MP:0002630	abnormal endocochlear potential	any alterations in the electrical potential difference (+80 - 100 mV) between the endolymphatic and perilymphatic compartments of the cochlea; this potential is generated by the stria vascularis
MP:0002631	abnormal epididymis morphology	any structural anomaly of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0002632	vestigial tail	a trace or rudimentary caudal structure, often a short boneless filament; the degenerated remains of any tail structure
MP:0002633	persistent truncus arteriosus	complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development
MP:0002634	abnormal sensorimotor gating	malfunction of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)
MP:0002635	reduced sensorimotor gating	attenuation of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)
MP:0002636	delayed vaginal opening	the opening of the genital canal in a female occurs at a later than expected age
MP:0002637	small uterus	reduced size of the female muscular organ of gestation
MP:0002638	abnormal pupillary reflex	alterations or failure of the pupil to change in diameter as a reflex response to any stimulus
MP:0002639	micrognathia	abnormally reduced size of the jaws, especially of the mandible
MP:0002640	reticulocytosis	an increase in the number of circulating reticulocytes, which is normally less than 1 per cent of the total number of red blood cells
MP:0002641	anisopoikilocytosis	presence in blood of RBCs of abnormal shapes and sizes
MP:0002642	anisocytosis	considerable variation of the size of red blood cells compared to a normal range
MP:0002643	poikilocytosis	blood cells of variable shape on smear
MP:0002644	decreased circulating triglyceride level	reduced concentration of naturally occurring esters of three fatty acids and glycerol in the blood; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver
MP:0002645	abnormal intestinal cholesterol absorption	any anomaly in the ability of the body to take up cholesterol into the blood by absorption from the small intestine
MP:0002646	increased intestinal cholesterol absorption	augmented ability of the body to take up cholesterol into the blood by absorption from the small intestine
MP:0002647	decreased intestinal cholesterol absorption	reduced ability of the body to take up cholesterol into the blood by absorption from the small intestine
MP:0002648	delaminated enamel	separation of the hard outer coating of the exposed portion of the tooth from the underlying hard tissue
MP:0002649	abnormal enamel rod pattern	any anomaly in the orientation of the structural unit of tooth enamel
MP:0002650	abnormal ameloblast morphology	any structural anomaly of the tall, columnar, polarized epithelial cell in the innermost layer of the enamel organ (inner enamel epithelium) of a developing tooth, involved with the formation of enamel matrix
MP:0002651	abnormal sciatic nerve morphology	any structural anomaly of the nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity
MP:0002652	thin myocardium	reduced thickness of the cardiac muscle layer
MP:0002653	abnormal ependyma morphology	any structural anomaly of the cellular membrane that lines the brain ventricles and the central canal of the spinal cord
MP:0002654	spongiform encephalopathy	a neurodegenerative state characterized by the appearance of large vacuolated areas in the brain cells, resembling a sponge
MP:0002655	abnormal keratinocyte morphology	any structural anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
MP:0002656	abnormal keratinocyte differentiation	developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
MP:0002657	chondrodystrophy	abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk
MP:0002658	abnormal liver regeneration	anomaly in the renewal, repair, and/or regrowth of liver tissue following injury or disease
MP:0002659	pituitary gland hypoplasia	decrease in the number of normal cells in normal arrangement in the pituitary, typically resulting in decreased size
MP:0002660	abnormal caput epididymis morphology	any structural anomaly of the head of the epididymis
MP:0002661	abnormal corpus epididymis morphology	any structural anomaly of the body of the epididymis
MP:0002662	abnormal cauda epididymis morphology	any structural anomaly of the tail of the epididymis
MP:0002663	absent blastocoele	developmental anomaly resulting in the absence of the cavity in the blastocyst of the developing embryo
MP:0002664	decreased circulating adrenocorticotropin level	decreased concentration in the blood of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex
MP:0002665	decreased circulating corticosterone level	less than the normal blood amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion
MP:0002666	increased circulating aldosterone level	increased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule
MP:0002667	decreased circulating aldosterone level	decreased in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule
MP:0002668	abnormal circulating potassium level	anomalous concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle
MP:0002669	abnormal scrotum morphology	any structural anomaly of the external sac of skin that encloses the testes
MP:0002670	absent scrotum	missing the external sac of skin that encloses the testes
MP:0002671	belted	the appearance of a stripe of white fur around the circumference of the abdomen
MP:0002672	abnormal pharyngeal arch artery morphology	any structural anomaly of the vessels formed within the six (five in mammals) pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels
MP:0002673	abnormal sperm number	increased or decreased numbers of spermatozoa
MP:0002674	abnormal sperm motility	anomalies in the mobility of the spermatozoa
MP:0002675	asthenozoospermia	loss or reduction of the mobility of the spermatozoa, frequently associated with infertility
MP:0002676	uterus hyperplasia	increase in the number of normal cells in normal arrangement in the uterus, typically resulting in increased size
MP:0002678	increased follicle recruitment	greater frequency of the entry of arrested primordial follicles into the pool of growing follicles
MP:0002679	abnormal corpus luteum morphology	any structural anomaly of the yellow endocrine body formed in the ovary after follicle rupture
MP:0002680	decreased corpora lutea number	fewer than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle
MP:0002681	increased corpora lutea number	greater than normal numbers of yellow endocrine body formed in the ovary after follicle rupture in a given oestrous cycle
MP:0002682	decreased mature ovarian follicle number	fewer than normal numbers of ovarian follicles that are ready for ovulation and present a blanched spot (the follicular stigma) where the graafian follicle is about to rupture on the surface of the ovary; a first maturation (meiotic) division of the primary oocyte usually occurs just prior to rupture of the follicle
MP:0002683	delayed fertility	ability to produce live offspring occurring at a later than expected age
MP:0002685	abnormal spermatogonia proliferation	anomaly in the proliferation of the spermatogonial stem cells either due to abnormal mitosis or apoptosis
MP:0002686	globozoospermia	any structural anomaly of the acrosome resulting in a round sperm head
MP:0002687	oligozoospermia	reduced concentration of spermatozoa in the cauda epididymis or seminal fluid
MP:0002688	obsolete increased sensitivity to addictive substance	OBSOLETE. decreased threshold to obtain a physiological or behavioral response to an addictive substance
MP:0002689	abnormal molar morphology	any structural anomaly of the most posterior teeth located on either side of the jaw, characterized by a large crown and broad chewing surface
MP:0002690	akinesia	acquired absence of voluntary movement or loss of the ability to move such as temporary or prolonged paralysis or freezing in place
MP:0002691	small stomach	reduced size of the stomach
MP:0002693	abnormal pancreas physiology	any functional anomaly of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream
MP:0002694	abnormal pancreas secretion	anomaly in the production and/or release of biologically active substances from pancreatic tissue
MP:0002695	abnormal circulating glucagon level	anomaly in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes
MP:0002696	decreased circulating glucagon level	reduction in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes
MP:0002697	abnormal eye size	deviation from the average range of eye size for a given organism
MP:0002698	abnormal sclera morphology	any structural anomaly of the fibrous, outer envelope of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea
MP:0002699	abnormal vitreous body morphology	any structural anomaly of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina
MP:0002700	increased opacity of vitreous body	the transparent gel filling the inner portion of the eyeball between the lens and retina becomes cloudy and impervious to light
MP:0002702	decreased circulating free fatty acids level	lower than normal levels of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues
MP:0002703	abnormal renal tubule morphology	any structural anomaly of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule
MP:0002704	tubular nephritis	inflammation of the renal tubules
MP:0002705	dilated renal tubule	stretched or widened aperture of the luminal space of one or more of the loops of Henle, proximal convoluted tubules or distal convoluted tubules
MP:0002706	abnormal kidney size	anomalous physical bulk one or both of the organs responsible for urine secretion
MP:0002707	abnormal kidney weight	anomaly in the average weight of the organs responsible for urine secretion
MP:0002708	nephrolithiasis	calculi (stones) occurring in the kidney
MP:0002710	increased glucagon secretion	greater than normal production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes
MP:0002711	decreased glucagon secretion	reduction in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes
MP:0002712	increased circulating glucagon level	increase in the blood concentration of the peptide hormone secreted by the alpha cells of the pancreas that normally plays an important role in regulation of blood glucose concentration, ketone metabolism, and several other biochemical and physiological processes
MP:0002713	abnormal glycogen catabolism	inability to breakdown glycogen; or reduced or increased rate of glycogen breakdown
MP:0002714	increased glycogen catabolism rate	increased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body
MP:0002715	decreased glycogen catabolism rate	decreased breakdown of this highly branched polysaccharide composed of glucose subunits; glycogen is the major carbohydrate storage form in the body
MP:0002716	small male preputial gland	reduced size of the sebaceous glands of the corona and neck of the glans penis
MP:0002717	abnormal male preputial gland morphology	any structural anomaly of the paired, lobulated, modified sebaceous glands of the corona, the neck of the glans penis, and the inner surface of the prepuce with pheromonal functions in male rodents; male preputial secretions strongly attract females, may accelerate estrus, and have been implicated in intermale aggression; homologous to the clitoral glands (aka female preputial glands) in female rodents; there is no true anatomical equivalent in humans
MP:0002718	abnormal inner cell mass morphology	any structural anomaly of the cells of the blastocyst that develop into the body of the embryo and some extraembryonic tissues
MP:0002720	obsolete urogenital system: dysmorphology	OBSOLETE. abnormal development of the urogenital system resulting in morphological abnormality
MP:0002721	obsolete abnormal urogenital system physiology	OBSOLETE.
MP:0002722	abnormal immune system organ morphology	any structural anomaly of lymphoid organs
MP:0002723	abnormal immune serum protein physiology	abnormal concentration or function of circulating immune proteins
MP:0002724	enhanced wound healing	increased ability to self-repair and close wounds
MP:0002725	abnormal vein morphology	any structural anomaly of the blood vessels that carry blood towards the heart
MP:0002726	abnormal pulmonary vein morphology	any structural anomaly of the veins that return oxygenated blood from the lungs to the left atrium of the heart
MP:0002727	decreased circulating insulin level	less than normal levels of insulin in the blood
MP:0002728	absent tibia	missing the medial and larger of the two bones of the lower leg
MP:0002729	abnormal inner ear canal morphology	any structural anomaly of the tubular ducts of the inner ear
MP:0002730	head shaking	repetitive movement of the head in the horizontal plane
MP:0002731	megacolon	extreme dilation of the colon
MP:0002732	increased trichoepithelioma incidence	greater than the expected number of benign hair follicle tumors that lack mature hair follicles, derived from basal cells of the hair follicles enclosing small keratin cysts, occurring in a specific population in a given time period
MP:0002733	abnormal thermal nociception	abnormal capability to sense pain elicited by thermal stimulation
MP:0002734	abnormal mechanical nociception	abnormal capability to sense pain elicited by mechanical stimulation
MP:0002735	abnormal chemical nociception	abnormal capability to sense pain elicited by chemical stimulation
MP:0002736	abnormal nociception after inflammation	changes in pain thresholds after inflammation
MP:0002738	hyperresponsive to tactile stimuli	exaggerated reflex action normally induced by touch or pain
MP:0002739	abnormal olfactory bulb development	abnormality in the progression of the formation of the olfactory bulb
MP:0002740	heart hypoplasia	decrease in the number of normal cells in normal arrangement in the heart, typically resulting in decreased size
MP:0002741	small olfactory bulb	reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex
MP:0002742	enlarged submandibular lymph nodes	increased size of the submandibular lymph nodes
MP:0002743	glomerulonephritis	inflammation and scarring damage to the glomerulus usually resulting from an autoimmune response; often characterized by decreased production of urine, the presence of blood and protein in the urine, and/or by edema; often leads to kidney failure
MP:0002745	abnormal atrioventricular valve morphology	any structural anomaly of the valves that gate the flow of blood from the atria into the ventricles
MP:0002746	abnormal semilunar valve morphology	any structural anomaly of the valves that gate the flow of blood from the ventricles into the aorta and pulmonary trunk
MP:0002747	abnormal aortic valve morphology	any structural anomaly of the valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle, and contains three cusps, the posterior (non-coronary), right anterior and left anterior cusps, attached to an outer fibrous ring (annulus)
MP:0002748	abnormal pulmonary valve morphology	any structural anomaly of the valve between the right ventricle and the pulmonary trunk, and contains three cusps, the anterior, right posterior and left posterior cusps, attached to an outer fibrous ring (annulus)
MP:0002750	exophthalmos	forward displacement, bulging, or protrusion of one or both eyeballs
MP:0002751	abnormal autonomic nervous system morphology	any structural anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions
MP:0002752	abnormal somatic nervous system morphology	any structural anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs)
MP:0002753	dilated heart left ventricle	the luminal space of the lower left chamber of the heart is increased in volume or area, usually with an increase in contained fluid
MP:0002754	dilated heart right ventricle	the luminal space of the lower right chamber of the heart is increased in volume or area, usually with an increase in contained fluid
MP:0002756	obsolete decreased pyramidal neuron number	OBSOLETE. fewer than average number of projection neurons in the hippocampus
MP:0002757	decreased vertical activity	lesser than average time spent jumping or rearing
MP:0002758	long tail	increased length of tail relative to average of a given reference population
MP:0002759	abnormal caudal vertebrae morphology	any structural anomaly of the bony segments of the coccyx or tail
MP:0002760	obsolete ectopic pyramidal neurons	OBSOLETE. abnormal position of one or more triangular shaped projection neurons in the hippocampus
MP:0002761	abnormal hippocampal mossy fiber morphology	absence or misprojection of axons of neuronal cells in the dentate gyrus
MP:0002762	ectopic cerebellar granule cells	granule cell body resides in a place other than the external or internal granule layer of the cerebellum
MP:0002763	ectopic Bergmann glia cells	abnormal position of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum
MP:0002764	short tibia	reduced length of the medial and larger bone of the lower leg
MP:0002765	short fibula	reduced length of the lateral and smaller of bone of the lower leg
MP:0002766	situs inversus	lateral transposition or mirroring of the viscera of the thorax and abdomen, sometimes incomplete, with all organs maintaining the normal relative position with respect to each other
MP:0002767	situs ambiguus	an abnormality in which the thoracic and abdominal organs are positioned in such a way with respect to each other and the left-right axis as to be not clearly lateralised and thus have neither the usual, or normal (situs solitus), nor the mirror-imaged (situs inversus) arrangements
MP:0002768	small adrenal glands	reduced size of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla
MP:0002769	abnormal vas deferens morphology	any structural anomaly of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct
MP:0002770	absent bulbourethral gland	absence of any of the small paired racemose (compound tubulo-alveolar) glands below the apex of the prostate in males, located posterolateral to the membranous portion of the urethra at the base of the penis, between the two layers of the fascia of the urogenital diaphragm, in the deep perineal pouch, and enclosed by transverse fibers of the sphincter urethrae membranaceae muscle; they secrete a clear fluid known as pre-ejaculate (Cowper's fluid), and are homologous to the greater vestibular (Bartholin's) glands in the female
MP:0002771	absent prostate gland anterior lobe	absence of the rodent prostate lobe that appears as a thin tubular structure, attached to the lesser curvature of the paired seminal vesicles
MP:0002772	brachypodia	decreased length of the autopod
MP:0002773	decreased circulating luteinizing hormone level	lower than normal levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary
MP:0002774	small prostate gland	reduced size of the gland in males that secretes part of the seminiferous fluid
MP:0002776	increased Sertoli cell number	increased number of the supporting cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis
MP:0002777	absent ovarian follicles	absence of the sac-like structure in the ovary which surrounds an ovum
MP:0002778	meroanencephaly	type of anencephaly in which the brain and cranium are present in rudimentary form
MP:0002779	abnormal sex gland secretion	anomaly in the production and/or release of hormones from a cell or a gland of the reproductive system
MP:0002780	decreased circulating testosterone level	reduction in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females
MP:0002781	increased circulating testosterone level	greater than the normal blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females
MP:0002782	abnormal testes secretion	anomaly in the production and/or release of hormones from testicular tissue
MP:0002783	abnormal ovary secretion	anomaly in the production and/or release of hormones from ovarian tissue
MP:0002784	abnormal Sertoli cell morphology	any structural anomaly of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis
MP:0002785	absent Leydig cells	lack of the interstitial cells of the seminiferous tubules that secrete testosterone
MP:0002786	abnormal Leydig cell morphology	any structural anomaly of the interstitial cells that are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH); Leydig cells are polyhedral in shape, display a large prominent nucleus, an eosinophilic cytoplasm and numerous lipid-filled vesicles
MP:0002787	pseudohermaphroditism	unambiguous gonadal sex (i.e. possesses either testes or ovaries, consistent with chromosomal sex) but has ambiguous secondary sexual characteristics
MP:0002788	female pseudohermaphroditism	pseudohermaphroditism in which the gonads are female (ovaries) and the karyotype is XX but the secondary sex characteristics are male-like or ambiguous
MP:0002789	male pseudohermaphroditism	pseudohermaphroditism in which the gonads are male (testes) and the karyotype is XY but the secondary sex characteristics are female-like or ambiguous
MP:0002790	decreased circulating follicle stimulating hormone level	less than expected blood concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0002791	steatorrhea	passage of large amounts of fat in the feces due to the inability to digest and absorb it
MP:0002792	abnormal retina vasculature morphology	any anomaly of the structure or arrangement of blood vessels supplying the retina
MP:0002794	lenticonus	a conical bulging of the lens capsule and the underlying cortex of the eye
MP:0002795	dilated cardiomyopathy	decreased function of the heart associated with cardiac enlargement and congestive heart failure
MP:0002796	impaired skin barrier function	impaired ability of the skin to regulate water loss; frequently leads to dehydration
MP:0002797	increased thigmotaxis	greater than average preference for staying at the perimeter walls of an open area or in an enclosed versus exposed area; may be used as an indicator of increased anxiety response
MP:0002798	abnormal active avoidance behavior	anomaly in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment
MP:0002799	abnormal passive avoidance behavior	anomaly in the ability of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously with prolonged latency
MP:0002800	abnormal short-term object recognition memory	anomaly in the short-term memory for objects is established during the first few minutes after training
MP:0002801	abnormal long-term object recognition memory	anomaly in long-term memory for objects that is consolidated over hours and days after training
MP:0002802	abnormal discrimination learning	anomaly in the ability to exhibit a differential response to different stimuli that is achieved by the reinforcement of the desired response for each particular stimulus
MP:0002803	abnormal operant conditioning behavior	anomaly in the operant conditioning system refers to abnormalities in scheduled controlled behavior; behavioral assessment occurs in an automated chamber where responses are reinforced with food
MP:0002804	abnormal motor learning	anomaly in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning
MP:0002805	abnormal conditioned taste aversion behavior	anomaly in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness
MP:0002806	abnormal conditioned emotional response	anomaly in an emotional response that has been acquired by conditioning
MP:0002807	abnormal eye blink conditioning behavior	anomaly in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an air puff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli
MP:0002808	abnormal barbering behavior	anomaly in the behavior of plucking of fur/hair or whiskers/vibrissae from other individuals of a cohort (hetero-barbering) or oneself (self-barbering); it is recognized as patches of unevenly chopped hair and the underlying skin is seldom inflamed
MP:0002809	increased spinal cord size	larger appearance of the spinal cord
MP:0002810	microcytic anemia	a reduction in the mean total mass of erythrocytes in which the remaining circulating erythrocyte corpuscular volume is smaller than normal; most commonly due to iron deficiency but also sickle cell disease and other conditions that result in hemoglobin synthesis failure or insufficiency
MP:0002811	macrocytic anemia	deficiency of red blood cells in which the remaining circulating erythrocyte corpuscular volume is larger than normal; most commonly due to megaloblastic anemia, or a deficiency of either vitamin B12 or folic acid
MP:0002812	spherocytosis	the presence of sphere-shaped erythrocytes in the circulating blood
MP:0002813	microcytosis	the presence of unusually small erythrocytes in the circulating blood
MP:0002814	hyperchromasia	increased capacity of a cell to stain with dye; usually refers to staining of cell nuclei with hematoxylin
MP:0002816	colitis	local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine
MP:0002817	abnormal tooth mineralization	abnormalities in the process by which calcium salts are deposited into the dental enamel, dentin and cementum
MP:0002818	abnormal dentin morphology	any structural anomaly in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root
MP:0002819	abnormal dental pulp cavity morphology	any structural anomaly of the central space (cavity) of a tooth that is bounded by dentin and contains the dental pulp; the portion of the cavity within the crown of the tooth is the pulp chamber; the portion within the root is the pulp canal or root canal
MP:0002820	abnormal premaxilla morphology	any structural anomaly of the anterior and inner portion of the maxilla
MP:0002822	catalepsy	a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions
MP:0002823	abnormal rib development	anomalous formation of the bones forming the bony wall of the chest
MP:0002824	abnormal chorioallantoic fusion	anomaly in the process by which a highly vascularized extra-embryonic fetal membrane is formed by fusion of the chorion and allantois; in most mammals, the chorioallantois constitutes the fetal portion of the placenta
MP:0002825	abnormal notochord morphology	any structural anomaly of the axial fibrocellular cord in embryos around which develops the vertebral primordia
MP:0002826	tonic seizures	increased number or decreased threshold for the induction of a seizure characterized by muscle rigidity
MP:0002827	abnormal renal corpuscle morphology	any structural anomaly of the structure containing the glomerular capsule and the glomerulus that serves as the initial blood-filtering component of a nephron
MP:0002828	abnormal renal glomerular capsule morphology	any structural anomaly of the expanded beginning of a nephron that contains the glomerulus
MP:0002829	abnormal juxtaglomerular apparatus morphology	any structural anomaly of the complex of modified smooth muscle cells consisting of juxtaglomerular cells, extraglomerular mesangium lacis cells, the macula densa of the distal convoluted tubule, and granular epithelial peripolar cells; these cells are found in the walls of afferent and efferent glomerular arterioles
MP:0002830	gallstones	caliculi in the gallbladder or a bile duct; chemical composition of cholesterol, calcium carbonate or calcium bilirubinate
MP:0002831	absent Peyer's patches	lymphoid tissue missing from the mucosa of the small intestine
MP:0002832	coarse hair	hair shafts that are twisted or coiled and are of uneven thickness produce an overall rugged or uneven appearance and roughness to the touch
MP:0002833	increased heart weight	greater than average weight of the heart compared to controls
MP:0002834	decreased heart weight	less than average weight of the heart compared to controls
MP:0002835	abnormal cranial suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the bones of the head
MP:0002836	abnormal chorion morphology	any structural anomaly of the outermost extraembryonic membrane
MP:0002837	dystrophic cardiac calcinosis	a condition characterized by the localized deposition of calcium salts in the heart; often occurring in association with inflammation or atherosclerotic lesions and other pathological states
MP:0002838	decreased susceptibility to dystrophic cardiac calcinosis	less likely to be stricken by dystrophic cardiac calcinosis
MP:0002839	increased susceptibility to dystrophic cardiac calcinosis	more likely to be stricken by dystrophic cardiac calcinosis
MP:0002840	abnormal lens fiber morphology	any structural anomaly of the elongated cells of the crystalline lens of the eye
MP:0002841	impaired skeletal muscle contractility	inability or reduced ability of the skeletal muscle to shorten or to develop increased tension
MP:0002842	increased systemic arterial blood pressure	increased tension of the blood within the systemic arteries
MP:0002843	decreased systemic arterial blood pressure	decreased tension of the blood within the systemic arteries
MP:0002844	aortic hypertrophy	increase in the bulk size of the aorta
MP:0002845	abnormal aortic weight	anomaly in the average weight of the aorta
MP:0002846	abnormal aortic mass	altered physical volume or bulk of the aorta
MP:0002847	abnormal renal glomerular filtration rate	anomaly in the rate of the process in which plasma is filtered through the glomerular membrane, which consists of capillary endothelial cells, the basement membrane, and epithelial cells; the glomerular filtrate is the same as plasma except it has no significant amount of protein
MP:0002848	obsolete increased surface glomeruli	OBSOLETE.
MP:0002849	abnormal saccharin consumption	anomaly in the amount of saccharin consumed in relation to other food
MP:0002850	saccharin preference	subjects demonstrate predilection for saccharine over other offered substance
MP:0002851	abnormal circulating sulfate level	altered concentration of sulfate in the blood
MP:0002852	hypersulfatemia	abnormally high concentration of sulfate in the circulating blood
MP:0002853	hyposulfatemia	abnormally low concentration of sulfate in the circulating blood
MP:0002855	abnormal cochlear ganglion morphology	any structural anomaly of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)
MP:0002856	abnormal vestibular ganglion morphology	any structural anomaly of the group of neurons associated with the vestibular part of the eighth cranial nerve that are involved in equilibration
MP:0002857	cochlear ganglion degeneration	loss of neural cell bodies in the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain
MP:0002858	abnormal posterior semicircular canal morphology	any structural anomaly of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0002859	abnormal inner ear canal fusion	any structural anomaly or mistiming of the fusion of the canal primordia during development
MP:0002861	abnormal tail bud morphology	anomalous formation of the primordial region of the embryo that arises to form the tail of the adult; appears approximately ten days following conception as a short stump, and then initiates elongation and thinning in normal development
MP:0002862	abnormal righting response	altered ability or changed amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position
MP:0002863	improved righting response	faster ability or less amount of time needed to recover from an unnatural position to a normal position and/or to resist any force acting to place an organism into a false position
MP:0002864	abnormal ocular fundus morphology	any structural anomaly of the posterior concave interior of the eye, consisting of the retina, the choroid, the posterior segment of the sclera, the optic disk, and blood vessels, visible by an ophthalmoscope
MP:0002865	increased growth rate	reduced length of time to reach a developmental stage or stages
MP:0002866	abnormal glutamic acid decarboxylase level	aberrant concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues
MP:0002867	increased glutamic acid decarboxylase level	greater than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide and regulates GABA levels in nervous tissues
MP:0002868	decreased glutamic acid decarboxylase level	less than normal concentration of the enzyme that catalyzes the conversion of glutamate to gamma-aminobutyric acid (GABA) and carbon dioxide, and regulates GABA levels in nervous tissues
MP:0002869	increased anti-insulin autoantibody level	elevated level of antibodies to insulin present in the sera
MP:0002870	decreased anti-insulin autoantibody level	reduced level of antibodies to insulin present in the sera
MP:0002871	albuminuria	presence of excess albumin in the urine
MP:0002872	polycythemia	an excess of circulating red blood cells
MP:0002873	normal phenotype	no phenotypic distinctions from controls
MP:0002874	decreased hemoglobin content	decrease in the total hemoglobin content in the circulating blood
MP:0002875	decreased erythrocyte cell number	reduced number of the cells that transport oxygen, red blood cells, per unit
MP:0002876	abnormal thyroid gland physiology	any functional anomaly of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body
MP:0002877	abnormal melanocyte morphology	any structural anomaly of the cells that produce pigment
MP:0002878	abnormal corticospinal tract morphology	any structural anomaly of the corticospinal fibers that arise from the pyramidal cells within the cerebral cortex layer V of the precentral motor area, the premotor area and the postcentral gyrus, then descend into and through the medulla to form the lateral corticospinal tract and the anterior corticospinal tract
MP:0002879	increased cellular sensitivity to X-ray irradiation	increased incidence of cell death following exposure to X-ray irradiation
MP:0002880	opisthotonus	a form of tetanic spasm in which the head, neck and spine are bent backward and the body is bowed forward
MP:0002881	long hair	increased average length of the coat hairs
MP:0002882	abnormal neuron morphology	any structural anomaly of the cells of the nervous system that receive, conduct, and transmit impulses
MP:0002883	chromatolysis	the dissolution of the granules of chromophil substance in a nerve cell body that may occur in injured cells or axons
MP:0002884	abnormal pharyngeal arch morphology	any structural anomaly of the transient structures of the embryo that develop into regions of the head, neck and ears
MP:0002885	abnormal AMPA-mediated synaptic currents	change in the measured amplitude, current density or duration of response to stimulation of AMPA receptors
MP:0002886	abnormal glutamate-mediated receptor currents	change in the measured amplitude, current density or duration of response to stimulation of glutamatergic receptors
MP:0002887	decreased susceptibility to pharmacologically induced seizures	ability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a higher threshold to induce seizure activity
MP:0002888	abnormal NMDA-mediated synaptic currents	change in the measured amplitude, current density or duration of response to stimulation of NMDA receptors
MP:0002891	increased insulin sensitivity	greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia
MP:0002892	decreased superior colliculus size	decreased size of the paired superior eminence of the mesencephalic tectum
MP:0002893	ketoaciduria	elevated amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the urine, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
MP:0002894	abnormal otolith morphology	any structural anomaly of the crystalline particles composed of calcium carbonate and a protein which adhere to the gelatinous membrane of the maculae of the utricle and saccule (otolithic membrane)
MP:0002895	abnormal otolithic membrane morphology	any structural anomaly of the gelatinous membrane which is supported by the stereocilia of the hair cells of the maculae of the saccule and utriculus of the inner ear; adhering to its surface are numerous calciferous crystalline particles called otoliths (statoconia)
MP:0002896	abnormal bone mineralization	defect in the process by which minerals are deposited into bone
MP:0002897	blotchy skin	regions of spotted discoloration appearing in the dermal tissue
MP:0002898	absent cartilage	absence of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the thorax, and tubular structures, but which also comprises most of the skeleton in early fetal life
MP:0002899	fatigue	easily exhausted due to mental or physical exertion
MP:0002900	abnormal urine phosphate level	any change in the amount of phosphate in the urine
MP:0002901	increased urine phosphate level	an increase in phosphate amount in the urine
MP:0002902	decreased urine phosphate level	reduced phosphate amount in the urine
MP:0002903	abnormal circulating parathyroid hormone level	anomaly in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body
MP:0002904	increased circulating parathyroid hormone level	greater blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body
MP:0002905	decreased circulating parathyroid hormone level	reduction in the blood concentration of the hormone that regulates and maintains intracellular calcium levels in the body
MP:0002906	increased susceptibility to pharmacologically induced seizures	inability to withstand doses of pharmacological drugs that induce seizure activity in normal animals; exhibit a lower threshold to induce seizure activity
MP:0002907	abnormal parturition	defect in the process of labor and delivery in female animals
MP:0002908	delayed wound healing	longer time requirement for the ability to self-repair and close wounds than normal
MP:0002909	abnormal adrenal gland physiology	any functional anomaly of the suprarenal gland, including the ability to produce and secrete hormones
MP:0002910	abnormal excitatory postsynaptic currents	any anomaly in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization
MP:0002911	abnormal inhibitory postsynaptic potential	defect in the membrane potential detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization
MP:0002912	abnormal excitatory postsynaptic potential	defect in the potential detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization
MP:0002913	abnormal PNS synaptic transmission	defect in the communication from a neuron to a target across a synapse in the peripheral nervous system
MP:0002914	abnormal endplate potential	defect in the excitatory response of peripheral synapses to stimulation; these amplitudes are larger than central synapse potentials
MP:0002915	abnormal synaptic depression	changes in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation
MP:0002916	increased synaptic depression	increase in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation
MP:0002917	decreased synaptic depression	decrease in the duration of the reduction of effectiveness of synaptic connections between neurons and target after repetitive stimulation
MP:0002918	abnormal paired-pulse facilitation	defects in the enhanced response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus
MP:0002919	enhanced paired-pulse facilitation	increase in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to greater increase of neurotransmitter release at the second stimulus
MP:0002920	decreased paired-pulse facilitation	reduction in the response of central synapses when activated twice in rapid succession; indicative of defects in short-term plasticity due to lack of increase of neurotransmitter release at the second stimulus
MP:0002921	abnormal post-tetanic potentiation	defects in the size or duration of potentials that persist after tetanic stimulation of central synapses
MP:0002922	decreased post-tetanic potentiation	reduction in the size or duration of potentials that persist after tetanic stimulation of central synapses
MP:0002923	increased post-tetanic potentiation	increase in the size or duration of potentials that persist after tetanic stimulation of central synapses
MP:0002924	delayed CNS synapse formation	increase in time required to complete the process of generating connections between an axon and effector tissue or neuron
MP:0002925	abnormal cardiovascular development	aberrant formation or incomplete differentiation of the cardiovascular system
MP:0002926	aganglionic megacolon	extreme dilation of the colon due to defects in innervation from the ganglia, or absence of the ganglia of the myenteric plexus
MP:0002927	toxic megacolon	severe non-obstructive dilation of the colon
MP:0002928	abnormal bile duct morphology	any structural anomaly of the channels that secrete bile from the liver to the gall bladder and intestines
MP:0002929	abnormal bile duct development	incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines
MP:0002930	obsolete hair cell degeneration	OBSOLETE. a retrogressive impairment of function, destruction or apoptosis of the sensory epithelial cells of the inner ear
MP:0002931	glutaricadicuria	an accumulation of an intermediate of tryptophan catabolism in the urine
MP:0002932	abnormal joint morphology	any structural anomaly of the moveable articulation point of two or more bones
MP:0002933	joint inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the joints
MP:0002934	acute joint inflammation	early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the joints; initiated by injury, infection, or local immune response
MP:0002935	chronic joint inflammation	persistent inflammatory response in the joints, often caused by persistent infection or during an autoimmune response
MP:0002936	joint swelling	enlargement of the joints, usually due to an accumulation of fluid
MP:0002937	synovial hyperemia	an increased blood flow to a synovial joint
MP:0002938	white spotting	the appearance of patches of white fur
MP:0002939	head spot	the appearance of a round area of white fur on the head
MP:0002940	variable body spotting	the appearance of patches of white fur at random on the coat
MP:0002941	increased circulating alanine transaminase level	increased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction
MP:0002942	decreased circulating alanine transaminase level	decreased concentration in the blood of the enzyme which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction
MP:0002943	abnormal lactate dehydrogenase level	abnormal level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate
MP:0002944	increased lactate dehydrogenase level	elevated level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate
MP:0002945	abnormal inhibitory postsynaptic currents	defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization
MP:0002946	delayed axon extension	an increased amount of time required for an axon to extend from a neuron cell body and find the target
MP:0002947	increased hemangioma incidence	greater than the expected number of benign tumors characterized by blood-filled spaces lined by benign endothelial cells, occurring in a specific population in a given time period; a cavernous hemangioma is characterized by large endothelial spaces (caverns), and a capillary hemangioma is characterized by small endothelial spaces
MP:0002948	abnormal neuron specification	defects in the developmental patterning of neurons resulting in ectopic placement, decreased numbers or absence of mature neurons
MP:0002949	obsolete abnormal neural crest cells	OBSOLETE. defect in the transient and migratory group of cells that emerge from the dorsal region of the neural tube and disperse to many peripheral locations to form various tissues of the adult
MP:0002950	abnormal neural crest cell migration	any anomaly in the dispersion of the transient and migratory group of cells that emerge from the dorsal region of the neural tube and migrate to many peripheral locations to form various tissues of the adult
MP:0002951	small thyroid gland	reduced size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin
MP:0002952	ventricular cardiomyopathy	diseases of the ventricles of the heart
MP:0002953	thick ventricular wall	increased depth of the cardiac wall of the heart ventricles
MP:0002954	obsolete abnormal aerobic energy metabolism	OBSOLETE. defect in respiratory chain energy production (oxidative metabolism) process in all living cells where oxygen is consumed and carbon dioxide and water are produced
MP:0002955	increased compensatory renal growth	increased additional growth of a kidney upon removal of the other kidney through surgery or disease
MP:0002956	decreased compensatory renal growth	decreased additional growth of a kidney upon removal of the other kidney through surgery or disease
MP:0002957	increased intestinal adenocarcinoma incidence	higher than normal incidence of a malignant neoplasm of epithelial cells in the intestine
MP:0002958	cerebral aqueductal stenosis	abnormal narrowing or constriction of the cerebral aqueduct that blocks the flow of cerebrospinal fluid (CSF) in the ventricular system
MP:0002959	increased urine microalbumin level	greater than the normal amount of microalbumin in the urine
MP:0002960	decreased urine microalbumin level	less than the normal amount of microalbumin in the urine
MP:0002961	abnormal axon guidance	defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues
MP:0002962	increased urine protein level	greater than the normal amount of proteins in the urine
MP:0002963	decreased urine protein level	less than the normal amount of proteins in the urine
MP:0002964	aortic elastic tissue lesions	focal pathological changes in the elastic lamella of the main trunk of the arterial system
MP:0002965	increased circulating serum albumin level	blood serum albumin concentration above the normal range
MP:0002966	decreased circulating alkaline phosphatase level	reduced concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters
MP:0002968	increased circulating alkaline phosphatase level	elevated concentration in the blood of the enzyme which hydrolyzes orthophosphoric monoesters
MP:0002969	impaired social transmission of food preference	defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues
MP:0002970	abnormal white adipose tissue morphology	any structural anomaly of the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels
MP:0002971	abnormal brown adipose tissue morphology	any structural anomaly of the thermogenic form of adipose tissue that is composed of brown adipocytes
MP:0002972	abnormal cardiac muscle contractility	altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
MP:0002975	vascular smooth muscle hypertrophy	increase in size or thickness of the smooth muscle of the vascular wall
MP:0002976	vascular smooth muscle hypotrophy	decrease in size or thickness of the smooth muscle of the vascular wall
MP:0002977	obsolete abnormal patterning of the aortic arch	OBSOLETE. abnormal development or differentiation of the convex portion of the aorta between the ascending and descending parts of the aorta
MP:0002978	absent otoliths	absence of the crystalline calciferous particles adhering to the otolithic membrane
MP:0002979	obsolete abnormal vestibular response	OBSOLETE. abnormal response to changes in motion
MP:0002980	abnormal postural reflex	any anomaly in the responses that control the normal position of the trunk and extremities and/or posture
MP:0002981	increased liver weight	a greater than average weight of the bile-secreting exocrine gland
MP:0002982	abnormal primordial germ cell migration	any anomaly in the orderly movement of a primordial germ cell, a cell specialized to produce haploid gametes, from one site to another during development
MP:0002983	increased retina ganglion cell number	greater number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
MP:0002984	retina hypoplasia	decrease in the number of normal cells in normal arrangement in the retina, typically resulting in decreased size
MP:0002985	abnormal urine calcium level	any change in the amount of calcium in the urine
MP:0002986	decreased urine calcium level	abnormally low amounts of calcium in the urine
MP:0002987	abnormal urine osmolality	changes in the amount of ions in the urine compared to the normal state
MP:0002988	decreased urine osmolality	reduction in the amount of ions in the urine compared to the normal state
MP:0002989	small kidney	reduced physical bulk one or both of the organs responsible for urine secretion
MP:0002990	short ureter	reduced length of the tube that conducts the urine from the renal pelvis to the bladder
MP:0002991	abnormal sebaceous gland physiology	any functional anomaly of the holocrine glands that secrete sebum into the hair follicles or in hairless areas into ducts
MP:0002992	abnormal sebaceous lipid secretion	abnormal function of the sebaceous gland resulting in changes to the lipid profile secreted onto the hair and skin
MP:0002993	autoimmune arthritis	autoimmune joint inflammation, marked by changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures
MP:0002995	primary sex reversal	gonad type is not consistent with chromosomal sex
MP:0002996	ovotestis	state in which a single recognizable gonad contains both testicular and ovarian tissue
MP:0002997	enlarged seminal vesicle	increased size of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0002998	abnormal bone remodeling	aberrant process of the continuous turnover of bone matrix and mineral that involves a balance of resorption and reactive bone formation by osteoclasts and osteoblasts, respectively
MP:0002999	abnormal bone healing	defects in the restoration of integrity to bone after trauma
MP:0003005	abnormal hippocampal fimbria morphology	any structural anomaly of the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure
MP:0003006	abnormal hippocampal fornix morphology	any structural anomaly of the compact, white, heavily myelinated fiber bundle arising from the Ammon horn of the hippocampus in each cerebral hemisphere and projecting to the hypothalamus and the mammillary body
MP:0003007	ectopic thymus	ectopic location of the thymus primordium, which normally resides in the superior mediastinum and lower part of the neck
MP:0003008	enhanced long-term potentiation	greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells
MP:0003009	abnormal cytokine secretion	anomaly in the production or cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells
MP:0003010	decreased mortality induced by ionizing radiation	reduced sensitivity to lethal doses of ionizing radiation such as ultraviolet light, X-rays, or gamma rays
MP:0003011	delayed dark adaptation	increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights
MP:0003012	obsolete no phenotypic analysis	Obsolete no description of morphological, physiological or behavioral information presented
MP:0003014	abnormal kidney medulla morphology	any structural anomaly of the inner portion of the kidney consisting of the renal pyramids
MP:0003015	abnormal circulating bicarbonate level	aberrant concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood
MP:0003016	increased circulating bicarbonate level	elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood
MP:0003017	decreased circulating bicarbonate level	reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood
MP:0003018	abnormal circulating chloride level	aberrant chloride concentration in the blood
MP:0003019	increased circulating chloride level	elevated chloride concentration in the blood
MP:0003020	decreased circulating chloride level	reduced chloride concentration in the blood
MP:0003021	abnormal coronary flow rate	aberrant rate of blood flow in the blood vessels supplying the heart
MP:0003022	increased coronary flow rate	elevated rate of blood flow in the blood vessels supplying the heart
MP:0003023	decreased coronary flow rate	reduced rate of blood flow in the blood vessels supplying the heart
MP:0003024	coronary artery stenosis	abnormal narrowing or constriction of any of the blood vessels supplying the heart
MP:0003025	increased vasoconstriction	greater ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels
MP:0003026	decreased vasoconstriction	reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels
MP:0003027	abnormal blood pH regulation	anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion
MP:0003028	alkalosis	a pathological condition characterized by a decrease in the hydrogen ion concentration in tissues and in blood; caused by an increase in the concentration of alkaline compounds, or by a decrease in the concentration of acidic compounds or carbon dioxide to the body fluids
MP:0003029	alkalemia	decreased concentration of H-ion in the blood or a rise in pH in the arterial blood
MP:0003030	acidemia	increased concentration of H-ion in the blood or a fall below normal in pH in the arterial blood
MP:0003031	acidosis	a pathological state characterized by an increase in the hydrogen ion concentration in tissues and blood caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids
MP:0003032	hypocapnia	reduced concentration of CO2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases
MP:0003033	abnormal pulmonary vascular resistance	deviation from the normal force opposing blood flow in the lung blood vessels
MP:0003034	increased pulmonary vascular resistance	greater than the normal force opposing blood flow in the lung blood vessels
MP:0003035	decreased pulmonary vascular resistance	less than the normal force opposing blood flow in the lung blood vessels
MP:0003036	vertebral transformation	homeotic transformation of a specific vertebrae to adopt the fate of another
MP:0003037	increased myocardial infarct size	increased size of necrotic area of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors
MP:0003038	decreased myocardial infarct size	decreased size of necrotic area of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors
MP:0003039	increased time of peak ischemic contracture	increased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction
MP:0003040	decreased time of peak ischemic contracture	decreased duration of time from normal necessary to achieve full irreversible contraction of the cardiac muscle in response to myocardial infarction
MP:0003041	increased time of onset of induced ischemic contracture	increased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction
MP:0003042	decreased time of onset of induced ischemic contracture	decreased duration of time from normal necessary to initiate the irreversible contraction of the cardiac muscle in response to induced myocardial infarction
MP:0003043	hypoalgesia	decreased sensitivity to painful stimuli; can be due to chemical intervention, neuropathies or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)
MP:0003044	impaired basement membrane formation	defect in the development of the extracellular supportive tissue closely adjacent to the basal surface of the epithelium of muscle cells, fat cells and Schwann cells, which is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components
MP:0003045	obsolete fibrosis	invasion of fibrous connective tissue into any organ or multiple organs, often resulting from inflammation or injury
MP:0003046	liver cirrhosis	liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure
MP:0003047	abnormal thoracic vertebrae morphology	any structural anomaly of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae
MP:0003048	abnormal cervical vertebrae morphology	any structural anomaly of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull
MP:0003049	abnormal lumbar vertebrae morphology	any structural anomaly of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0003050	abnormal sacral vertebrae morphology	any structural anomaly of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae
MP:0003051	curly tail	a loop or corkscrew-like curl in the tail
MP:0003052	omphalocele	protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion, that is caused by a severe body wall defect
MP:0003053	delayed tooth eruption	postponed onset of the growth of the teeth out of the gums
MP:0003054	spina bifida	common congenital midline defect of fusion of the vertebral arch
MP:0003055	abnormal long bone epiphyseal plate morphology	any structural anomaly of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles
MP:0003056	abnormal hyoid bone morphology	any structural anomaly of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles
MP:0003057	abnormal epicardium morphology	any structural anomaly of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart
MP:0003058	increased insulin secretion	greater production or release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
MP:0003059	decreased insulin secretion	reduction in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
MP:0003060	increased aerobic running capacity	greater ability to run at defined speeds and/or distances compared to controls
MP:0003061	decreased aerobic running capacity	reduced ability to run at defined speeds and/or distances compared to controls
MP:0003062	abnormal coping response	altered ability to respond productively to a stressful situation or stimulus, or failure to seek pleasurable stimuli
MP:0003063	increased coping response	enhanced ability to respond productively to a stressful situation
MP:0003064	decreased coping response	reduced ability to respond productively to a stressful situation
MP:0003065	abnormal liver copper level	anomaly in the amount of copper present in the liver tissue
MP:0003066	increased liver copper level	a greater accumulation of copper in the liver tissue compared to controls
MP:0003067	decreased liver copper level	a reduced amount of copper in the liver tissue compared to controls
MP:0003068	enlarged kidney	larger than average size of the kidney
MP:0003069	abnormal superior semicircular canal morphology	any structural anomaly of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0003070	increased vascular permeability	greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases
MP:0003071	decreased vascular permeability	reduced or slower ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases
MP:0003072	abnormal metatarsal bone morphology	any structural anomaly in the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges
MP:0003073	abnormal metacarpal bone morphology	any structural anomaly in the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges
MP:0003074	absent metacarpal bones	missing all of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges
MP:0003075	abnormal response to CNS ischemic injury	altered response to lack of adequate blood flow, due to trauma or disease, to support the normal functioning of a tissue in the central nervous system
MP:0003076	increased susceptibility to ischemic brain injury	more severe response, such as increased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of all or part of the brain compared to controls
MP:0003077	abnormal cell cycle	failure to progress or abnormal progression through the stages of the cell cycle
MP:0003078	aphakia	absence of the crystalline lens of the eye
MP:0003079	decreased susceptibility to induced joint inflammation	reduced or absent inflammatory response in the joints due to chemical or mechanical agents
MP:0003080	increased natural killer cell mediated cytotoxicity	increased ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors
MP:0003081	abnormal soleus morphology	any structural anomaly of the superficial flat broad muscle of the calf that is responsible for plantar flexion of the foot
MP:0003082	abnormal gastrocnemius morphology	any structural anomaly of the two-headed large muscle of the posterior portion of the lower hindleg, the most superficial of the calf muscles
MP:0003083	abnormal tibialis anterior morphology	any structural anomaly of the muscle of the shin that is responsible for dorsiflexion and inversion of the foot
MP:0003084	abnormal skeletal muscle fiber morphology	any structural anomaly of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles
MP:0003085	abnormal egg cylinder morphology	any structural anomaly in the transient cup-like structure of the epiblast that consists of a single layer of embryonic cells
MP:0003086	hydromyelia	increased fluid in the central canal of the spinal cord
MP:0003087	absent allantois	missing fetal membrane which contributes to the formation of the umbilical cord and placenta
MP:0003088	abnormal prepulse inhibition	anomaly in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus
MP:0003089	decreased skin tensile strength	reduction in the normal maximum tension the skin can withstand without tearing
MP:0003090	abnormal muscle precursor cell migration	defects in the movement of cells that will develop into muscle cells out of the somites and/or to the appropriate location in the body
MP:0003091	abnormal cell migration	any anomaly in the movement of cells from one site to another, often occurring during developmental or chemotactic processes
MP:0003092	decreased cornea stroma thickness	reduced width of the lamellated connective tissue layer of the cornea
MP:0003093	abnormal cornea anterior stroma morphology	any structural anomaly of the anterior segment of the lamellated connective tissue layer of the cornea
MP:0003094	abnormal cornea posterior stroma morphology	any structural anomaly of the posterior segment of the lamellated connective tissue layer of the cornea
MP:0003095	abnormal cornea stroma development	anomalous differentiation of the lamellated connective tissue layer of the cornea
MP:0003096	increased corneal light-scattering	anomaly in the normal transmission of light through the cornea; light is reflected or absorbed instead; often due to anomalies in the arrangement of lamella in the corneal stroma
MP:0003097	abnormal tendon stiffness	altered ability of tendon to maintain tensile strength and load
MP:0003098	decreased tendon stiffness	reduced ability of tendon to maintain tensile strength and load
MP:0003099	retina detachment	part or all of the retinal neural layer is separated from the outer pigmented layer of the retina; may occur with aging or as a result of trauma
MP:0003100	myopia	optical condition in which only rays from a finite distance from the eye focus on the retina
MP:0003101	high myopia	an optical condition involving enlarging of the eye, scleral thinning and frequent detachment of the retina resulting from stress associated with excessive axial elongation
MP:0003102	sclera thinning	reduction in the width of the fibrous, outer envelope of the eyeball, the sclera may appear blue as a result of the underlying epithelium showing through
MP:0003103	liver degeneration	deterioration of the liver due to injury or disease, often accompanied by loss of function
MP:0003104	acrania	complete or partial absence of a skull; usually associated with anencephaly
MP:0003105	abnormal heart atrium morphology	any structural anomaly of one or both of the two upper chambers of the heart, to which the blood returns from the circulation
MP:0003106	abnormal fear-related response	altered emotional response related to anticipation of specific pain or danger
MP:0003107	abnormal response to novelty	alteration in amount of exploration/investigation of a novel object, situation or environment
MP:0003108	short zygomatic bone	reduced length of the bone that forms the prominence of the cheek
MP:0003109	short femur	reduced length of the long bone of the thigh
MP:0003110	absent malleus processus brevis	absence of the short projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane where the tympanic cavity makes a deep pocket (epitympanic pocket) surrounding the cartilaginous nodule
MP:0003111	abnormal cell nucleus morphology	any structural anomaly of a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated; in most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing, but in some species, or in specialized cell types, RNA metabolism or DNA replication may be absent
MP:0003112	enlarged parathyroid gland	increased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003113	small parathyroid gland	decreased size of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003114	pigmented parathyroid gland	presence of melanocytes and/or melanin in either of the two small, paired endocrine glands, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; they secrete parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003115	abnormal respiratory system development	aberrant differentiation of pulmonary tissues
MP:0003116	rickets	overproduction and deficient calcification of osteoid tissue due to vitamin D deficiency; can lead to skeletal deformities, growth defects, hypocalcemia, and sometimes tetany; skeletal fractures occur frequently
MP:0003118	obsolete abnormal tracheal-bronchial branching morphogenesis	OBSOLETE. partial or complete failure of the trachea and bronchi to repeatedly divide during development of the lung
MP:0003119	abnormal digestive system development	abnormal formation of the organ system that converts ingested food to nutrients and energy
MP:0003120	abnormal tracheal cartilage morphology	any structural anomaly of the cartilaginous structures that support the trachea and prevent it from collapsing
MP:0003121	genetic imprinting	the process that modulates the frequency, rate or extent of the chemical reactions and pathways involving macromolecules by a mechanism that is mediated by DNA, is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence
MP:0003122	maternal imprinting	the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the maternal germline, but that are not encoded by DNA itself
MP:0003123	paternal imprinting	establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal germline, but that are not encoded by DNA itself
MP:0003124	hypospadia	a urethral opening located below the normal location; in males, the abnormally placed opening is usually on the ventral surface of the penis, and in females, the abnormally placed opening is usually in the vagina
MP:0003125	abnormal septation of the cloaca	absence of or reduction in the separation of the single opening of the digestive, urinary, and reproductive tracts (cloaca) into multiple isolated openings during development, may result in hypospadia, reduced anogenital distance, or persistent cloaca
MP:0003126	abnormal external female genitalia morphology	any structural anomaly of the external feminine genital organs, collectively known as the vulva and composed of the mons pubis, the labia majora and minora, the clitoris, the vestibule of the vagina and its glands, and the opening of the urethra and of the vagina
MP:0003127	abnormal clitoris morphology	any structural anomaly of the small, erectile body located at the anterior end of the vulva
MP:0003128	splayed clitoris	flattened or spread out clitoris
MP:0003129	persistent cloaca	persistence of an early embryonic state in which the urinary, genital, and gastrointestinal tracts remain confluent and communicate with the exterior through a single perineal opening; due to failure of the urogenital septum to divide the embryonic cloaca into rectal and urogenital portions
MP:0003130	anal atresia	congenital absence of an anal opening due to the persistence of the epithelial plug (persistence of the anal membrane) or to complete absence of the anal canal
MP:0003131	increased erythrocyte cell number	greater number of the cells that transport oxygen, red blood cells, per unit
MP:0003132	increased pre-B cell number	greater number of progenitor cells that form the B cell component of the immune system
MP:0003133	increased early pro-B cell number	greater number of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain
MP:0003134	increased late pro-B cell number	greater number of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain
MP:0003135	increased erythroid progenitor cell number	greater numbers of progenitors of the erythrocyte lineage
MP:0003136	yellow coat color	amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is maximally increased in agouti hair
MP:0003137	abnormal impulse conducting system conduction	any functional anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart
MP:0003138	absent tympanic ring	missing the bony ring at the ear canal to which the tympanic membrane is attached
MP:0003139	patent ductus arteriosus	failure of the fetal connection between the aorta and pulmonary artery to close after birth
MP:0003140	dilated heart atrium	the luminal space of one or both of the upper chambers of the heart is increased in volume or area, usually with an increase of contained fluid
MP:0003141	cardiac fibrosis	formation of fibrous tissue within the heart often resulting from inflammation or injury
MP:0003142	anotia	congenital absence of one or both auricles of the ears
MP:0003143	enlarged otoliths	increased average size of the crystalline calciferous particles adhering to the otolithic membrane
MP:0003144	decreased otolith number	reduced average number of the crystalline calciferous particles adhering to the otolithic membrane
MP:0003145	detached otolithic membrane	part or all of the otolithic (otoconial) membrane is abnormally separated from the sensory epithelium (macula) of the utricle and/or saccule
MP:0003146	absent cochlear ganglion	absence of the group of nerve cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)
MP:0003147	absent cochlea	absence or agenesis of the spiral-shaped bony canal in the inner ear containing the hair cells that transduce sound
MP:0003148	decreased cochlea coiling	a reduction in cochlear coiling or number of turns; in wild-type mice, the cochlea most commonly exhibits one and three-fourth turns
MP:0003149	abnormal tectorial membrane morphology	any structural anomaly of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells; sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair cell membrane potential, transducing sound into electrical signals
MP:0003150	detached tectorial membrane	tectorial membrane is abnormally detached from the cochlear epithelium or spiral limbus
MP:0003151	absent tunnel of Corti	complete absence of the triangular, fluid-filled space normally found between the inner and outer rows of supporting pillar cells in the organ of Corti
MP:0003152	abnormal pillar cell differentiation	abnormal differentiation of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti
MP:0003153	early eyelid opening	early average time for the first postnatal eye opening
MP:0003154	abnormal soft palate morphology	any structural anomaly of the musculomembranous fold that partly separates the mouth and pharynx, located behind the hard palate in the adult
MP:0003155	abnormal telomere length	abnormal length of the terminal repetitive DNA section of a chromosome that is involved in chromosomal replication and senescence and protects the end of the chromosome from deterioration; normal length is a few hundred base pairs
MP:0003156	abnormal leukocyte migration	altered ability of blood leukocytes to move within or between different tissues and organs of the body by binding to high endothelial venules (HEV), then tethering and rolling along the luminal aspects of HEV
MP:0003157	impaired muscle relaxation	reduced or absent ability of muscle to lengthen following contractions
MP:0003158	dysphagia	difficulty in swallowing food or liquid
MP:0003159	abnormal esophageal smooth muscle morphology	any structural anomaly of the nonstriated, involuntary muscle tissue lining the esophagus
MP:0003160	abnormal esophagus development	aberrant formation of the part of the digestive canal through which food passes from the pharynx to the stomach
MP:0003161	absent lateral semicircular canal	absence of the lateral long bony tube of the labyrinth that is involved in the sense of balance
MP:0003162	decreased lateral semicircular canal size	small size of the lateral long bony tube of the labyrinth that is involved in the sense of balance
MP:0003163	absent posterior semicircular canal	absence of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0003164	decreased posterior semicircular canal size	small size of the posterior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0003165	absent superior semicircular canal	absence of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0003166	decreased superior semicircular canal size	small size of the upper, superior segment of the long bony tube of the labyrinth that is involved in the sense of balance
MP:0003167	abnormal scala tympani morphology	any structural anomaly of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina
MP:0003168	abnormal scala vestibuli morphology	any structural anomaly of the division of the spiral canal of the cochlea lying on the apical side of the spiral lamina and vestibular membrane
MP:0003169	abnormal scala media morphology	any structural anomaly of the division of the spiral canal of the cochlea that contains the organ of Corti (the neuroepithelial receptor organ for hearing)
MP:0003171	phenotypic reversion	wild-type phenotype restored from a previously characterized mutant phenotype
MP:0003172	abnormal lysosome physiology	ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired
MP:0003173	decreased lysosomal enzyme secretion	production or release of glycoprotein hydrolytic enzymes is decreased compared to normal
MP:0003174	increased lysosomal enzyme secretion	production or secretion of glycoprotein hydrolytic enzymes is increased compared to normal
MP:0003175	reversion by mitotic recombination	cross-over event between sequences containing mutant and wild-type alleles during DNA replication in a heterozygote resulting in cells with two wild-type alleles
MP:0003176	reversion by viral sequence excision	restoration of wild-type phenotype by removal of a viral sequence or a viral- related sequence that produced a mutant phenotype
MP:0003177	allodynia	condition in which nonpainful stimuli evoke a pain sensation
MP:0003178	left pulmonary isomerism	anomaly in the asymmetry of the lung such that the lobes on both the left and right side have the morphology normally seen on the left side of the body
MP:0003179	thrombocytopenia	fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation
MP:0003180	abnormal pulmonary endothelial cell surface	altered morphology or area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell
MP:0003181	increased pulmonary endothelial cell surface	increased total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell
MP:0003182	decreased pulmonary endothelial cell surface	reduced total area of the semipermeable membrane that encloses the cytoplasm of a pulmonary endothelial cell
MP:0003183	obsolete abnormal peptide metabolism	anomaly in the biochemical modification and homeostasis of molecules consisting of linked amino acids and their derivatives
MP:0003184	increased angiotensin I-converting enzyme activity	greater activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin
MP:0003185	decreased angiotensin I-converting enzyme activity	reduced activity of the exopeptidase that catalyses the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, and is also involved in the inactivation of bradykinin
MP:0003186	abnormal redox activity	defect in the processes that maintain the redox environment of a cell or compartment within a cell
MP:0003187	obsolete increased reduction	OBSOLETE.
MP:0003188	obsolete decreased reduction	OBSOLETE.
MP:0003189	fused joints	partial or complete absence of a functional articulation point of two or more bones
MP:0003190	fused synovial joints	partial or complete absence of separations containing synovial fluid between bones
MP:0003191	abnormal cellular cholesterol metabolism	impaired regulation of cellular cholesterol levels
MP:0003192	increased cholesterol efflux	greater level of removal of excess cholesterol from cells by an active transport pathway
MP:0003193	decreased cholesterol efflux	reduced level of removal of excess cholesterol from cells by an active transport pathway
MP:0003194	abnormal frequency of paradoxical sleep	abnormal incidence or duration of the sleep stage in which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity
MP:0003195	calcinosis	pathologic deposition of calcium salts in tissues
MP:0003196	calcified skin	pathologic deposition of calcium salts in the skin
MP:0003197	nephrocalcinosis	diffusely scattered foci of calcification in the renal parenchyma, with microscopic or macroscopic deposits of calcium salts
MP:0003198	calcified tendon	pathologic deposition of calcium salts in the tendons
MP:0003199	calcified muscle	pathologic deposition of calcium salts in muscle
MP:0003200	calcified joint	pathologic deposition of calcium salts in the joints
MP:0003201	extremity edema	an accumulation of serous fluid in the limbs, paws and tail
MP:0003202	abnormal neuron apoptosis	change in the timing or the number of neurons undergoing programmed cell death
MP:0003203	increased neuron apoptosis	increase in the number of neurons undergoing programmed cell death
MP:0003204	decreased neuron apoptosis	decrease in the number of neurons undergoing programmed cell death
MP:0003205	testicular atrophy	acquired diminution of the size of the testis associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0003207	decreased cellular sensitivity to gamma-irradiation	decreased incidence of cell death following exposure to gamma-irradiation
MP:0003208	abnormal neuromere morphology	any structural anomaly of the segments of the developing neural tube
MP:0003209	abnormal pulmonary elastic fiber morphology	any structural anomaly of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity
MP:0003210	abnormal heart elastic fiber morphology	any structural anomaly of the slender connective tissue fiber in cardiac tissue characterized by great elasticity
MP:0003211	abnormal aorta elastic fiber morphology	any structural anomaly of the slender connective tissue fiber in aortic tissue characterized by great elasticity
MP:0003212	increased susceptibility to age related obesity	increased probability of excessive weight gain that is progressive with age
MP:0003213	decreased susceptibility to age related obesity	reduced probability of excessive weight gain that is progressive with age
MP:0003214	neurofibrillary tangles	dense intraneuronal accumulations of helical filaments (neurofilaments and microtubules) that assume twisted contorted patterns; found in subclasses of cells of the neocortex, hippocampus, brain stem, and diencephalon in individuals with Alzheimer disease and other tauopathies
MP:0003215	renal interstitial fibrosis	formation of fibrous tissue within the functional space in the kidney beneath the individual filters (glomeruli) as a result of repair or a reactive process
MP:0003216	absence seizures	impairment of consciousness without convulsions associated with sudden behavioral arrest and widespread bilaterally synchronous spike-and-wave discharges (SWDs) in the electroencephalogram (EEG)
MP:0003217	increased spike-wave discharge type I	increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than spike-wave discharge type II
MP:0003218	decreased spike-wave discharge type I	decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by immediate, bilaterally symmetric discharges, generalized over the cortex and lasting longer than Spike-wave discharge type II
MP:0003219	increased spike-wave discharge type II	increase in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I
MP:0003220	decreased spike-wave discharge type II	decrease in one type of epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy, characterized by local occipital-parietal discharges that are shorter and have less clear waves than spike-wave discharge type I
MP:0003221	abnormal cardiomyocyte apoptosis	change in the timing or the number of cardiac muscle cells undergoing programmed cell death
MP:0003222	increased cardiomyocyte apoptosis	increase in the number of cardiac muscle cells undergoing programmed cell death
MP:0003223	decreased cardiomyocyte apoptosis	decrease in the number of cardiac muscle cells undergoing programmed cell death
MP:0003224	neuron degeneration	a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses
MP:0003225	axonal dystrophy	axon degeneration that may result from genetic abnormalities or inadequate or faulty metabolism
MP:0003226	absent cochlear modiolus	absence of the central cone shaped core of spongy bone about which turns the spiral canal
MP:0003227	abnormal vascular branching morphogenesis	increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels
MP:0003228	abnormal sinus venosus morphology	any structural anomaly of the cavity at the caudal end of the embryonic cardiac tube in which the veins from the intra- and extraembryonic circulatory arcs unite; in the adult this becomes the portion of the right atrium known as the sinus of the vena cava
MP:0003229	abnormal vitelline vasculature morphology	any structural anomaly of the vascular network that supplies the yolk sac
MP:0003230	abnormal umbilical artery morphology	any structural anomaly of the paired arteries that bring unoxygenated blood back to the placenta from the dorsal aorta through the umbilical cord
MP:0003231	abnormal placenta vasculature	any structural anomaly of the vessels of the placenta
MP:0003232	abnormal forebrain development	anomaly in the formation or patterning of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)
MP:0003233	prolonged QT interval	increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
MP:0003234	enhanced NMDA-mediated synaptic currents	increase in the measured amplitude, current density or duration of response to stimulation of NMDA receptors
MP:0003235	abnormal alisphenoid bone morphology	any structural anomaly of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young
MP:0003236	abnormal lens capsule morphology	any structural anomaly of the elastic, clear, membrane-like structure, that is outer most layer of the lens
MP:0003237	abnormal lens epithelium morphology	any structural anomaly in the one or more of the layers of epithelial cells in the lens
MP:0003238	slow REM	decreased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place
MP:0003239	fast REM	increased rapid, periodic, jerky movement of the eyes from average during certain stages of the sleep cycle when dreaming takes place
MP:0003240	loss of hippocampal neurons	loss of neurons in the hippocampal region of the brain, commonly due to an apoptotic event
MP:0003241	loss of cortex neurons	loss of neurons in the cortex region of the brain, commonly due to an apoptotic event
MP:0003242	loss of basal ganglia neurons	loss of neurons in the basal ganglia of the brain, commonly due to an apoptotic event
MP:0003243	abnormal dopaminergic neuron morphology	any structural anomaly of the neurons that utilize dopamine as a neurotransmitter
MP:0003244	loss of dopaminergic neurons	loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event
MP:0003245	abnormal GABAergic neuron morphology	any structural anomaly of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter
MP:0003246	loss of GABAergic neurons	loss of the neurons that utilize gamma-aminobutyric acid as a neurotransmitter, commonly due to an apoptotic event
MP:0003247	abnormal glutaminergic neuron morphology	any structural anomaly of the neurons that utilize glutamate as a neurotransmitter
MP:0003248	loss of glutamate neurons	loss of the neurons that utilize glutamate as a neurotransmitter, commonly due to an apoptotic event
MP:0003249	increased muscle free fatty acids level	greater than normal muscle concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacylglycerols are taken into tissues
MP:0003250	absent gallbladder	absence of the organ which serves as a storage reservoir for bile
MP:0003251	gallbladder inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the gall bladder
MP:0003252	abnormal bile duct physiology	any functional anomaly of the channels that secrete bile from the liver to the gall bladder and intestines
MP:0003253	dilated bile duct	the luminal space of one or more bile ducts is increased in volume or area, usually with an increase in contained fluid or bile
MP:0003254	bile duct inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts
MP:0003255	bile duct proliferation	the appearance of an increased number of bile ducts in the liver; a sign of progressive liver disease
MP:0003256	biliary cirrhosis	liver damage to parenchymal cells due to obstruction of bile flow in the bile ducts
MP:0003257	abnormal abdominal wall morphology	any structural anomaly of the margins that enclose the abdominal cavity; the major part is muscular but also includes skin, subcutaneous fat, fascia and the parietal peritoneum
MP:0003258	hiatal hernia	protrusion of abdominal structures through the esophageal hiatus of the diaphragm
MP:0003259	nausea	gastric discomfort associated with the inclination to vomit
MP:0003260	vomiting	the retrograde expulsion of gastric contents through the oral cavity
MP:0003261	hematemesis	vomiting of blood; indicative of bleeding in the upper gastrointestinal tract
MP:0003262	intestinal/bowel diverticulum	a pouch or sac protruding from the intestinal or bowel wall
MP:0003263	obsolete abnormal cholesterol biosynthesis	OBSOLETE. altered ability to form cholesterol from constituent compounds
MP:0003264	obsolete increased cholesterol biosynthesis	OBSOLETE. augmented rate at which cholesterol is formed from constituent compounds
MP:0003265	obsolete decreased cholesterol biosynthesis	OBSOLETE. reduced rate at which cholesterol is formed from constituent compounds
MP:0003266	biliary cyst	presence of one or more abnormal fluid-filled sacs within the bile ducts
MP:0003267	constipation	incomplete, infrequent or difficult evacuation of fecal matter
MP:0003268	chronic constipation	prolonged or long-term difficulty in evacuation of fecal matter
MP:0003269	colon polyps	abnormal tissue masses that protrude into the lumen of the colon and are tethered to the wall of the colon
MP:0003270	intestinal obstruction	any impediment, blockage, or reversal of the normal flow of the intestinal contents toward the anus
MP:0003271	abnormal duodenum morphology	any structural anomaly of the first division of the small intestine that extends from the pyloris to the junction with the jejunum
MP:0003272	duodenal atresia	congenital blockage or absence of the lumen of the duodenum
MP:0003273	duodenal ulcer	a lesion on the mucosal surface of the duodenum, usually produced by the sloughing of inflammatory necrotic tissue
MP:0003274	intestinal microaneurysm	focal dilation of arteriocapillary junctions in the intestine
MP:0003275	gastric microaneurysm	focal dilation of arteriocapillary junctions in the stomach
MP:0003276	esophageal atresia	congenital blockage or absence of the lumen of the esophagus
MP:0003277	increased esophageal papilloma incidence	higher than normal incidence of a benign epithelial tumor consisting of villous or arborescent outgrowths of fibrovascular stroma of the esophagus
MP:0003278	esophageal inflammation	local accumulation of fluid, plasma proteins and leukocytes in the esophagus
MP:0003279	aneurysm	a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle
MP:0003280	urinary incontinence	inability to control the urinary bladder excretory functions leading to involuntary urination
MP:0003281	fecal incontinence	inability to control the anal sphincter resulting in the involuntary passage of feces
MP:0003282	gastric ulcer	a lesion on the mucosal surface of the stomach, usually produced by the sloughing of inflammatory necrotic tissue
MP:0003283	abnormal digestive organ placement	different location or arrangement of any of the alimentary tract organs
MP:0003284	abnormal large intestine placement	different location or arrangement of the large intestinal tract
MP:0003285	gastric hypertrophy	increase in the bulk size of the stomach due to cell enlargement or accumulation of fluids
MP:0003286	gastroesophageal reflux	retrograde movement of gastric contents into the esophagus
MP:0003287	increased intestinal hemangioma incidence	greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the intestines, occurring in a specific population in a given time period
MP:0003288	intestinal edema	an accumulation of an excessive amount of serous fluid in the intestine or intestinal cells
MP:0003289	abnormal intestinal peristalsis	altered intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward
MP:0003290	intestinal hypoperistalsis	reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward
MP:0003291	interstinal hyperperistalsis	increased intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward
MP:0003292	melena	dark colored, foul-smelling feces due to the presence of blood
MP:0003293	rectal hemorrhage	bleeding in the rectum
MP:0003294	intussusception	telescoping of the intestine, or the prolapse of one part of the bowel to another; usually results in obstruction
MP:0003295	lymphomesenteric cyst	cystic mass in the abdominal mesenchyme containing lymph; sometimes becomes calcified
MP:0003296	microcolon	small, unused colon in neonates, usually due to atresia or other gastrointestinal blockage
MP:0003298	choking	spasm of the larynx and trachea due to prevention of respiration by compression or obstruction
MP:0003299	gastric polyps	abnormal tissue masses that protrude into the lumen of the stomach and are tethered to the wall of the stomach
MP:0003300	gastrointestinal ulcer	any lesion on the mucosal surface of the gastrointestinal tract, usually produced by the sloughing of inflammatory necrotic tissue
MP:0003301	peptic ulcer	any lesion on the mucosal surface of the portion of the alimentary tract that is exposed to gastric acid, usually in the stomach or the duodenum
MP:0003302	perirectal abscess	acute focal inflammation of the tissues surrounding the rectum, often with accumulation of purulent material
MP:0003303	peritoneal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the membrane that lines the abdominal cavity and covers most of the viscera
MP:0003304	large intestinal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the large intestine
MP:0003305	proctitis	local accumulation of fluid, plasma proteins, and leukocytes in the mucous membrane of the rectum
MP:0003306	small intestinal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the small intestine
MP:0003307	pyloric stenosis	abnormal narrowing or constriction of the gastric outlet of the stomach, often due to muscular hypertrophy or scarring from local inflammation
MP:0003308	abnormal cochlear sensory epithelium morphology	any structural anomaly of the epithelial cell layer containing the sensory hair cells and their associated sensory nerve terminals
MP:0003309	abnormal cochlear modiolus morphology	any structural anomaly of the central cone shaped core of spongy bone about which turns the spiral canal
MP:0003310	reduced cochlear modiolus	a reduction in the volume of the central conical bony pillar of the cochlea
MP:0003311	aminoaciduria	excretion of amino acids in the urine, especially in excessive amounts
MP:0003312	abnormal locomotor coordination	reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in behavioral locomotor activity
MP:0003313	abnormal locomotor activation	altered ability or desire of an animal to initiate locomotor activity
MP:0003314	dysmetria	an inability to control the range of motion, typified by under- or over-shooting the intended position with the hand, arm, leg or eye
MP:0003315	abnormal perineum morphology	any structural anomaly of the area between the genital organs and the anus that lies beneath the pelvic diaphragm
MP:0003316	perineal fistula	an abnormal anatomical passage that connects the perineum to organs such as the bladder or the rectum
MP:0003317	anoperineal fistula	an abnormal anatomical passage that connects the perineum to the anal canal
MP:0003318	rectoperineal fistula	an abnormal anatomical passage that connects the perineum to the rectum
MP:0003319	anal fistula	an abnormal anatomical passage at or near the anus that usually opens into the rectum above the internal sphincter
MP:0003320	rectovaginal fistula	an abnormal anatomical passage connecting the rectum and the vagina
MP:0003321	tracheoesophageal fistula	an abnormal passage is present between the esophagus and the trachea; may be acquired or congenital, and is often associated with esophageal atresia
MP:0003322	biliary fistula	an abnormal anatomical passage that connects any organ of the biliary tract and other organs
MP:0003323	gastrocolic fistula	an abnormal anatomical passage between the stomach and the colon
MP:0003324	increased liver adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the liver, occurring in a specific population in a given time period
MP:0003325	decreased liver function	reduced normal function of this bile-secreting exocrine gland, which is important for detoxification, for fat, carbohydrate, and protein metabolism, and for glycogen storage
MP:0003326	liver failure	cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage
MP:0003327	liver cyst	presence of one or more abnormal membranous sacs in any portion of the liver
MP:0003328	portal hypertension	elevation of blood pressure in the hepatic portal vein, often a result of cirrhosis or from obstruction of the portal vein
MP:0003329	amyloid beta deposits	formation of self-assembled aggregates of the cleaved App Abeta protein fragment; often seen in neurodegenerative disorders such as Alzheimer's disease
MP:0003330	abnormal auditory tube morphology	any structural anomaly in the tube connecting the tympanic cavity and the nasopharynx that allows equalization of pressure between the tympanic cavity and the environment
MP:0003331	increased hepatocellular carcinoma incidence	greater than the expected number of a malignant neoplasm arising from liver cells, usually in adults and caused by liver trauma due to disease or injury, occurring in a specific population in a given time period
MP:0003332	liver abscess	collection of purulent exudate within the liver as a result of infection by bacteria, protozoa, or other agents
MP:0003333	liver fibrosis	invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury
MP:0003334	pancreas fibrosis	invasion of fibrous connective tissue into the pancreas, often resulting from inflammation or injury
MP:0003335	exocrine pancreatic insufficiency	inadequate synthesis and/or secretion of digestive enzymes by the exocrine portion of the pancreas, usually due to loss of acinar tissue from idiopathic atrophy or acute or chronic inflammation, causing maldigestion and malabsorption of nutrients
MP:0003336	pancreas cyst	presence of one or more abnormal fluid-filled sacs within the pancreas
MP:0003337	exocrine pancreas hyperplasia	increase in the number of normal cells in normal arrangement in the exocrine pancreas, typically resulting in increased size
MP:0003338	pancreas lipomatosis	an accumulation of abnormally localized or tumor-like fat in the pancreas
MP:0003339	decreased pancreatic beta cell number	fewer than normal number of the cells of the pancreas that secrete insulin
MP:0003340	acute pancreas inflammation	early and often transient reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into the pancreas; initiated by injury, infection, or local immune response
MP:0003341	chronic pancreas inflammation	persistent inflammatory response in the pancreas, often caused by persistent infection or during an autoimmune response
MP:0003342	accessory spleen	the splenic tissue is divided into equal masses; often related to situs inversus
MP:0003344	mammary gland hypoplasia	decrease in the number of normal cells in normal arrangement in the mammary gland, typically resulting in decreased size
MP:0003345	decreased rib number	fewer than normal numbers of the pairs of bony structures that make up the body wall
MP:0003346	abnormal pectoral muscle morphology	any structural anomaly of the two muscles that make up the upper and fore part of the chest that adduct and rotate the arm and lift the ribs
MP:0003347	hyperpituitarism	hypersecretion of adenohypophyseal hormones from the glandular, anterior portion of the pituitary; often due to a functional adenoma
MP:0003348	hypopituitarism	reduction or cessation of secretion of one or more hormones from the anterior pituitary gland; this may result from ablation, tumors, infarction, or other trauma
MP:0003349	abnormal circulating renin level	aberrant blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I
MP:0003350	increased circulating levels of thyroid hormone	increased concentration of hormones in the blood that are synthesized and secreted by the thyroid
MP:0003351	decreased circulating levels of thyroid hormone	reduced concentration of hormones in the blood that are synthesized and secreted by the thyroid
MP:0003352	increased circulating renin level	elevated blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I
MP:0003353	decreased circulating renin level	reduced blood level of the enzyme which is secreted by the kidney and cleaves a bond in angiotensionogen to generate angiotensin I
MP:0003354	astrocytosis	a proliferation or spread of astrocytes into the area of a degenerative lesion or damaged tissue
MP:0003355	decreased ovulation rate	reduction in the frequency in which an ovum (or ova) is/are released from a rupturing ovarian follicle(s)
MP:0003356	impaired luteinization	atypical transformation of the mature ovarian follicle and its theca interna into a corpus luteum after ovulation
MP:0003357	impaired granulosa cell differentiation	atypical production of or inability to produce the supporting cells for the developing female gamete in the ovary of mammals; granulosa cells form a single layer around the mammalian oocyte in the primordial ovarian follicle and advance to form a multilayered cumulus oophorus surrounding the ovum in the Graafian follicle
MP:0003358	abnormal hypaxial muscle morphology	any structural anomaly of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue
MP:0003359	hypaxial muscle hypoplasia	decrease in the number of normal cells in normal arrangement in the hypaxial muscle, typically resulting in decreased size
MP:0003360	abnormal depression-related behavior	responses to a stressful situation or stimulus, or failure to seek pleasurable stimuli
MP:0003361	abnormal circulating gonadotropin level	aberrant blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis
MP:0003362	increased circulating gonadotropin level	greater than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis
MP:0003363	decreased circulating gonadotropin level	less than the normal blood concentration of the peptide hormones that stimulate gonadal functions such as gametogenesis and sex steroid hormone production in the ovary and the testis
MP:0003364	increased insulinoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet beta cells, occurring in a specific population in a given time period; these tumors secrete excess insulin
MP:0003365	increased glucagonoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the pancreatic islet alpha cells, occurring in a specific population in a given time period; these tumors secrete excess glucagon
MP:0003366	abnormal circulating glucocorticoid level	aberrant blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity
MP:0003367	increased circulating glucocorticoid level	greater than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity
MP:0003368	decreased circulating glucocorticoid level	less than normal blood concentration of the corticosteroids regulating carbohydrate metabolism and exhibiting anti-inflammatory activity
MP:0003369	abnormal circulating estrogen level	aberration in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics
MP:0003370	increased circulating estrogen level	greater than normal blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics
MP:0003371	decreased circulating estrogen level	reduction in the blood concentration of any substance that causes development of the female reproductive organs and secondary sexual characteristics
MP:0003372	abnormal circulating mineralocorticoid level	aberrant blood concentration of corticosteroids that influence water and electrolyte metabolism and balance
MP:0003373	increased circulating mineralocorticoid level	greater than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance
MP:0003374	decreased circulating mineralocorticoid level	less than normal blood concentration of corticosteroids that influence water and electrolyte metabolism and balance
MP:0003375	abnormal menstrual cycle	failure of or aberrant timing of a recurring cycle in human primates in which the endometrial lining of the uterus prepares for pregnancy and ovulation occurs; if pregnancy does not occur the lining is discharged at menstruation
MP:0003376	amenorrhea	absence or abnormal cessation of the shedding of the endometrium and associated bleeding in primates
MP:0003377	late onset of menarche	the onset of menstrual cycles occurs at a later age than normal
MP:0003378	early sexual maturation	pubertal changes occur at an earlier than normal age
MP:0003379	absent sexual maturation	failure to initiate pubertal changes that result in achievement of full sexual capacity
MP:0003380	abnormal intestine regeneration	anomaly in the renewal, repair, and/or regrowth of intestinal tissue following injury or disease
MP:0003381	vitreal fibroplasia	production of excess fibrous tissue in the vitreous body of the eye
MP:0003382	straub tail	condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment
MP:0003383	abnormal gluconeogenesis	anomaly in the formation of glucose from non-carbohydrates, such as proteins or fat
MP:0003384	abnormal ventral body wall morphology	any structural anomaly of the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity
MP:0003385	abnormal body wall morphology	any structural anomaly of the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity
MP:0003386	obsolete increased sensitivity to nicotine	OBSOLETE. decreased threshold to obtain a physiological or behavioral response to nicotine
MP:0003387	aorta coarctation	a congenital focal constriction of the aorta most commonly found just distal to the origin of the left subclavian artery; the most commonly found form is juxtaductal coarctation, but it may occur at any point from the transverse arch to the iliac bifurcation
MP:0003388	absent pericardium	absence of the fibroserous membrane covering the heart and beginning of the great vessels
MP:0003389	constriction of pericardium	tightening of the pericardium around the heart
MP:0003390	lymphedema	abnormal swelling in the soft tissues of the limbs, or less often the trunk, caused by the buildup of lymph fluid
MP:0003391	increased myxoma incidence	higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; may show multiple differentiated components
MP:0003392	increased atrial myxoma incidence	higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of either the left or right atrium connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix; an increase in primary intracardiac tumor incidence
MP:0003393	decreased cardiac output	reduction in the blood volume pumped by each ventricle per minute
MP:0003394	increased cardiac output	greater than normal blood volume pumped by each ventricle per minute
MP:0003395	abnormal subclavian artery morphology	any structural anomaly of the right or left subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body and the left subclavian artery extends from the aortic arch to the left side of the body
MP:0003396	abnormal embryonic hematopoiesis	anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages that circulate in the embryonic and extraembryonic tissues, and which occurs in blood islands in the yolk sac from E7-E11 in the mouse and through 10 weeks in humans
MP:0003397	increased muscle weight	greater than average muscle weight
MP:0003398	increased skeletal muscle size	greater than average dimensions of one or more of the muscles of the skeleton
MP:0003400	kinked neural tube	twists or kinks in the embryonic neural tube
MP:0003401	enlarged tail bud	increased size or area of the primordial region of the embryo that arises to form the tail of the adult
MP:0003402	decreased liver weight	reduced average weight of the bile-secreting exocrine gland
MP:0003403	absent placental labyrinth	absence of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood
MP:0003404	absent enamel	absence of the hard outer coating of the exposed portion of the tooth
MP:0003405	abnormal platelet shape	any anomaly in the characteristic surface outline or contour of the normal small, disk-like shape of blood plasma cells derived from megakaryocytes and which function to promote blood clotting
MP:0003406	failure of zygotic cell division	inability of a fertilized oocyte to initiate or complete early cell divisions
MP:0003407	abnormal central nervous system regeneration	anomaly in the renewal, repair, and/or regrowth of central nervous system tissue following injury or disease
MP:0003408	increased width of hypertrophic chondrocyte zone	increased width of cartilage cell matrix layer
MP:0003409	decreased width of hypertrophic chondrocyte zone	decreased width of cartilage cell matrix layer
MP:0003410	abnormal artery development	anomaly in the process of forming the blood vessels that carry blood away from the heart
MP:0003411	abnormal vein development	anomaly in the process of forming the blood vessels that carry blood to the heart
MP:0003412	abnormal afterhyperpolarization	anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration
MP:0003413	hair follicle degeneration	a retrogressive impairment of function or destruction of the hair follicle
MP:0003414	epidermal cyst	presence of one or more benign masses derived from the epidermis or the epithelium of a hair follicle, formed by enclosure of epithelium within the dermis and filled with keratin and lipid-rich inclusions
MP:0003415	priapism	prolonged penile erection, often painful and without sexual desire
MP:0003416	premature bone ossification	early onset of the formation of bone
MP:0003417	premature endochondral bone ossification	early onset of bone formation in bones that form from cartilage
MP:0003418	premature intramembranous bone ossification	early onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle
MP:0003419	delayed endochondral bone ossification	late onset of bone formation in bones that form from cartilage
MP:0003420	delayed intramembranous bone ossification	late onset of bone formation in bones that form without a cartilaginous intermediate including the cranium and clavicle
MP:0003421	abnormal thyroid gland development	failure or abnormality in the formation of the thyroid gland during organogenesis
MP:0003422	abnormal thrombolysis	altered ability to break up (lyse) blood clots that are restricting the blood flow
MP:0003423	reduced thrombolysis	reduced ability or inability to break up (lyse) blood clots that are restricting the blood flow
MP:0003424	premature neuronal precursor differentiation	earlier than normal transformation of neuronal precursor cells into neurons
MP:0003425	abnormal optic vesicle formation	anomalous formation of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop
MP:0003426	pulmonary interstitial fibrosis	formation of fibrous tissue within the interstices of the lung as a result of repair or a reactive process
MP:0003427	parakeratosis	thickening of the stratum corneum of the epidermis (hyperkeratosis) with nucleated keratinocytes retained in this layer
MP:0003429	insensitivity to growth hormone	no growth response to exogenous growth hormone
MP:0003430	increased pancreatic islet cell adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the islet cells of the pancreas, occurring in a specific population in a given time period
MP:0003431	abnormal parathyroid gland physiology	any functional anomaly of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003432	increased activity of parathyroid	increased function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003433	decreased activity of parathyroid	reduced function of this paired endocrine gland that normally produces parathyroid hormone (PTH) that regulates calcium and phosphorous metabolism
MP:0003434	decreased susceptibility to induced choroidal neovascularization	reduction or absence of growth of new, abnormal blood vessels that originate in the choroid through a break in the Bruch membrane into the sub-retinal pigment epithelium or subretinal space and may result in visual loss as a result of chemical or mechanical manipulation (e.g. laser-induced trauma)
MP:0003435	herniated seminal vesicle	protrusion of the seminal vesicles through the pelvic outlet
MP:0003436	decreased susceptibility to induced arthritis	less likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents
MP:0003437	abnormal carotid body morphology	any structural anomaly of a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control
MP:0003438	abnormal carotid body physiology	any functional anomaly in a small epithelioid structure consisting of a small cluster of chemoreceptive and supporting cells located near the bifurcation of the common carotid artery that serves as a chemoreceptive organ that senses the pH, carbon dioxide, and oxygen concentrations in the blood and plays a crucial role in their homeostatic control
MP:0003439	abnormal glycerol level	abnormal level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source
MP:0003440	decreased glycerol level	reduced level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source
MP:0003441	increased glycerol level	elevated level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source
MP:0003442	decreased circulating glycerol level	reduced blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source
MP:0003443	increased circulating glycerol level	elevated blood level of trihydroxy sugar alcohols that are precursors for synthesis of triacylglycerols, and of phospholipids and cellular glucose in the liver and adipose tissue; fat catabolism results in the release of glycerol and fatty acids into the bloodstream to be used as an energy source
MP:0003444	abnormal neurotransmitter uptake	aberration in the reabsorption of endogenous signaling molecules released into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell
MP:0003445	sirenomelia	fusion of the caudal-most (posterior or lower) limbs often with partial or complete fusion of the autopods
MP:0003446	renal hypoplasia	decrease in the number of normal cells in normal arrangement in the kidney, typically resulting in decreased size
MP:0003447	decreased tumor growth/size	less than expected development of tumorous growth when compared to controls
MP:0003448	abnormal tumor morphology	any structural anomaly of a given tumor type compared to controls
MP:0003449	abnormal intestinal goblet cell morphology	any structural anomaly of the glandular simple columnar epithelial cell found in the mucosal lining of the small and large intestine, whose primary function is to secrete gel-forming mucins, the major components of mucus; the goblet cell is a highly polarized unicellular exocrine gland with the nucleus and other organelles concentrated at the base of the cell; the remainder of the cell's cytoplasm is occupied by membrane-bound secretory granules containing mucin; the goblet shape is due to the mucus laden granules in the apical part expanding, causing that part of the cell to balloon; the apical plasma membrane projects microvilli to give an increased surface area for secretion
MP:0003450	enlarged pancreas	increase of the size of the pancreas compared to controls
MP:0003451	absent olfactory bulb	absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex
MP:0003452	abnormal parotid gland morphology	any structural anomaly of either of the largest of the major salivary glands situated below and in front of each ear
MP:0003453	abnormal keratinocyte physiology	abnormal function of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum
MP:0003454	erythroderma	exfoliation and widespread, intense reddening of the skin due to inflammatory skin disease
MP:0003455	decreased susceptibility to induced retina damage	reduced or absent pathological changes in the retina due to chemical or mechanical agents
MP:0003456	absent tail	completely lacking the appendage at the caudal end of the vertebral column
MP:0003457	abnormal circulating ketone body level	aberrant amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
MP:0003458	decreased circulating ketone body level	less than the normal amount of acetoacetate, 3-hydroxybutyrate (beta-hydroxybutyrate) and/or acetone in the blood, which are produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus
MP:0003459	increased fear-related response	greater emotional response related to anticipation of specific pain or danger
MP:0003460	decreased fear-related response	reduced emotional response related to anticipation of specific pain or danger
MP:0003461	abnormal response to novel object	altered behavioral reaction associated with exposing an animal to a novel object
MP:0003462	abnormal response to novel odor	altered behavioral reaction associated with exposing an animal to a novel odor
MP:0003463	abnormal single cell response	altered values from controls obtained upon extra- or intracellular recordings from single cells
MP:0003464	abnormal single cell response threshold	any change in the value at which a stimulus first elicits a recordable response recorded in a single cell
MP:0003465	increased single cell response threshold	increase in the value at which a stimulus first elicits a recordable response recorded in a single cell
MP:0003466	decreased single cell response threshold	reduction in the value at which a stimulus first elicits a recordable response recorded in a single cell
MP:0003467	abnormal single cell response intensity	any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell
MP:0003468	increased single cell response intensity	increase in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell
MP:0003469	decreased single cell response intensity	reduction in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single cell
MP:0003470	abnormal summary potential	anomaly in the electrophysiological recording of the activity of several cells
MP:0003471	abnormal summary potential threshold	any change in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice
MP:0003472	increased summary potential threshold	increase in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice
MP:0003473	decreased summary potential threshold	reduction in the value at which a stimulus first elicits a recordable response recorded in several cells or a tissue slice
MP:0003474	abnormal summary potential intensity	any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice
MP:0003475	increased summary potential intensity	increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice
MP:0003476	decreased summary potential intensity	reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in several cells or a tissue slice
MP:0003477	abnormal nerve fiber response	anomaly in the electrophysiological recordings from a single or several nerve fiber(s)
MP:0003478	abnormal nerve fiber response threshold	any change in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)
MP:0003479	abnormal nerve fiber response intensity	any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)
MP:0003480	increased nerve fiber response intensity	increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)
MP:0003481	decreased nerve fiber response intensity	reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded in a single or several nerve fiber(s)
MP:0003482	increased nerve fiber response threshold	increase in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)
MP:0003483	decreased nerve fiber response threshold	reduction in the value at which a stimulus first elicits a recordable response recorded in a single or several nerve fiber(s)
MP:0003484	abnormal channel response	anomalies in the electrophysiological recordings from ion channels
MP:0003485	abnormal channel response threshold	any change in the value at which a stimulus first elicits a recordable response recorded from ion channels
MP:0003486	abnormal channel response intensity	any change in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels
MP:0003487	increased channel response intensity	increase in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels
MP:0003488	decreased channel response intensity	reduction in the value for changes in the degree of de- or hyperpolarization or number of action potentials in response to a specific stimulus recorded from ion channels
MP:0003489	increased channel response threshold	increase in the value at which a stimulus first elicits a recordable response recorded from ion channels
MP:0003490	decreased channel response threshold	reduction in the value at which a stimulus first elicits a recordable response recorded from ion channels
MP:0003491	abnormal voluntary movement	anomaly in coordinated movements executed with a purpose and can be improved by learning and/or experience
MP:0003492	abnormal involuntary movement	anomaly in movements that occur independent of planning (e.g. reflexive behavior)
MP:0003493	parathyroid gland hyperplasia	increase in the number of normal cells in normal arrangement in the parathyroid gland, typically resulting in increased size
MP:0003494	parathyroid hypoplasia	decrease in the number of normal cells in normal arrangement in the parathyroid gland, typically resulting in decreased size
MP:0003495	increased parathyroid adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the parathyroid gland, occurring in a specific population in a given time period
MP:0003496	increased thyroid adenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in the thyroid gland, occurring in a specific population in a given time period
MP:0003497	insensitivity to parathyroid hormone	no changes in calcium homeostasis in response to endogenous or exogenous hormone
MP:0003498	thyroid gland hyperplasia	increase in the number of normal cells in normal arrangement in the thyroid gland, typically resulting in increased size
MP:0003499	thyroid gland hypoplasia	decrease in the number of normal cells in normal arrangement in the thyroid gland, typically resulting in decreased size
MP:0003501	iodide oxidation defect	thyroid defect in oxidation and organification of iodide
MP:0003502	increased activity of thyroid gland	increased function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body
MP:0003503	decreased activity of thyroid gland	reduced function of this endocrine gland that normally produces hormones that regulate the metabolic rate of the body
MP:0003504	thyroid gland inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the thyroid gland
MP:0003505	increased prolactinoma incidence	greater than the expected number of a pituitary adenoma characterized by secretion of prolactin, occurring in a specific population in a given time period
MP:0003506	acromegaly	excessive secretion of growth hormone resulting in progressive enlargement of the face, hands, feet, head, and thorax; organomegaly and impaired glucose homeostasis may ensue
MP:0003507	abnormal ovary physiology	any functional anomaly of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone
MP:0003508	abnormal circulating dihydrotestosterone level	aberration in the blood concentration of a potent androgenic metabolite of testosterone
MP:0003509	increased circulating dihydrotestosterone level	greater than normal blood concentration of this potent androgenic metabolite of testosterone
MP:0003510	decreased circulating dihydrotestosterone level	reduction in the blood concentration of a potent androgenic metabolite of testosterone
MP:0003511	abnormal labium morphology	any structural anomaly of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening
MP:0003512	enlarged labia	increased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening
MP:0003513	small labia	decreased size of the folds of skin which form the inner lips (labia minora) and outer lips (labia majora) on both sides of the vaginal opening
MP:0003514	interlabial sulcus	the presence of grooves or furrows in the folds of skin which lips on both sides of the vaginal opening
MP:0003515	abnormal labia majora morphology	any structural anomaly of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening
MP:0003516	absent labia majora	absence of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening
MP:0003517	enlarged labia majora	increased size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening
MP:0003518	small labia majora	reduced size of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening
MP:0003519	splayed labia majora	flattened or spread out appearance of the folds of skin which form the outer lips (labia majora) on both sides of the vaginal opening
MP:0003520	abnormal labia minora morphology	any structural anomaly of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening
MP:0003521	absent labia minora	absence of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening
MP:0003522	enlarged labia minora	increased size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening
MP:0003523	small labia minora	reduced size of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening
MP:0003524	splayed labia minora	flattened or spread out appearance of the folds of skin which form the inner lips (labia minora) on both sides of the vaginal opening
MP:0003525	vulva warts	benign epithelial growths of the external genitalia of the female
MP:0003526	vulva cyst	presence of one or more abnormal membranous sacs in the vulva
MP:0003527	small vulva	decreased size of the external genitalia of the female
MP:0003528	enlarged vulva	increased size of the external genitalia of the female
MP:0003529	enlarged clitoris	increased size of the small, erectile body located at the anterior end of the vulva
MP:0003530	small clitoris	reduced size of the small, erectile body located at the anterior end of the vulva
MP:0003531	abnormal vagina development	abnormal morphogenesis of the female reproductive canal located between the uterus and the vulva
MP:0003533	bifid vagina	cleft of the female reproductive canal located between the uterus and the vulva into two parts or branches
MP:0003534	blind vagina	presence the female reproductive canal that ends in a sac and does not connect to internal genitalia
MP:0003535	absent vagina	absence of the female reproductive canal located between the uterus and the vulva
MP:0003536	vagina dryness	lack of the normal presence or reduced presence of secretions in the vagina
MP:0003537	hydrometrocolpos	collection of fluid in the vagina; often due to a congenital obstruction
MP:0003538	abnormal hymen development	anomaly in the morphogenesis of the thin membrane which may partially occlude the opening of the vagina; often absent in normal females
MP:0003539	absent hymen	absence of the thin membrane which may partially occlude the opening of the vagina
MP:0003540	imperforate hymen	absence of the normal opening of the thin membrane which may partially occlude the opening of the vagina; here the opening is completely occluded
MP:0003541	vaginal inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the vagina
MP:0003542	abnormal vascular endothelial cell development	anomaly in the differentiation of the cells that line the vasculature
MP:0003543	abnormal vascular endothelial cell differentiation	anomaly in the process whereby a relatively unspecialized cell acquires specialized features of an endothelial cell
MP:0003544	abnormal vascular endothelial cell migration	anomaly in the movement of endothelial cell or their precursors to the appropriate location in the body
MP:0003545	increased alcohol consumption	greater than normal consumption of alcohol
MP:0003546	decreased alcohol consumption	less than normal consumption of alcohol
MP:0003547	abnormal pulmonary pressure	altered tension of the blood within the pulmonary arteries
MP:0003548	pulmonary hypertension	sustained high pulmonary pressure at a level that is likely to result in disease and/or other pathological states
MP:0003549	pulmonary hypotension	sustained low pulmonary pressure at a level that is likely to result in disease and/or other pathological states
MP:0003550	short perineum	reduced length of the area between the genital organs and the anus that lies beneath the pelvic diaphragm
MP:0003551	blind perineal pouch	opening in the perineum leading to a blind-ending sac
MP:0003552	vagina cyst	presence of one or more benign epithelial growths in the vagina
MP:0003553	abnormal foreskin morphology	any structural anomaly of the loose fold of skin that covers the penis
MP:0003554	phimosis	inability of the penis to protrude from the prepuce/foreskin; may be due to a narrow opening of the foreskin resulting in the inability to retract the distal foreskin over the glans penis
MP:0003555	chordee	acute angulation of the penis upon erection; often painful and due to disease or congenital malformation
MP:0003557	absent vas deferens	absence of the secretory duct of the testicle that carries spermatozoa, running from the epididymis, of which it is the continuation, to the prostatic urethra where it terminates to form ejaculatory duct
MP:0003558	absent uterus	absence of the female muscular organ of gestation
MP:0003559	bifid uterus	cleft of the female muscular organ of gestation into two parts or branches, often having the appearance of two lobes
MP:0003560	osteoarthritis	a type of arthritis that results in the breakdown and eventual loss of the articular cartilage of one or more joints
MP:0003561	rheumatoid arthritis	an autoimmune response that primarily affects connective tissue; it also results in chronic inflammation of the joints, especially of the hands and feet and may also cause inflammation of the tissue around the joints, as well as other organs in the body
MP:0003562	abnormal pancreatic beta cell physiology	anomaly in the function of the cells that secrete insulin and are located towards the center of the islets of Langerhans in the pancreas
MP:0003563	abnormal pancreatic alpha cell physiology	anomaly in the function of the glucagon-producing cells of the islets of Langerhans in the pancreas
MP:0003564	abnormal insulin secretion	anomaly in the production or release of the hormone secreted by beta cells of the pancreas that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids
MP:0003565	abnormal glucagon secretion	anomaly in the production or release of this hormone secreted by the alpha cells of the islets of Langerhans; it normally plays a role in regulation of blood glucose concentration, ketone metabolism, and other biochemical and physiological processes
MP:0003566	abnormal cell adhesion	altered ability of a cell to adhere to another cell or to a non-cellular component of the environment
MP:0003567	abnormal fetal cardiomyocyte proliferation	anomaly in the ability of the differentiating cardiac muscle cell population to undergo expansion by cell division
MP:0003568	uterus atresia	congenital absence of the normal opening or lumen of the uterus
MP:0003569	increased leiomyoma incidence	greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle, occurring in a specific population in a given time period
MP:0003570	increased uterus leiomyoma incidence	greater than the expected number of a benign tumor derived from smooth (nonstriated) muscle of the uterus, occurring in a specific population in a given time period
MP:0003571	uterus rupture	tearing of the uterine tissue; may be due to trauma or pregnancy complications
MP:0003572	abnormal uterus development	abnormal morphogenesis of the female muscular organ of gestation
MP:0003574	abnormal oviduct morphology	any structural anomaly of the tube through which the ova pass from the ovary to the uterus
MP:0003575	absent oviduct	absence of the tube through which the ova pass from the ovary to the uterus
MP:0003576	oviduct hypoplasia	decrease in the number of normal cells in normal arrangement in the oviduct, typically resulting in decreased size
MP:0003578	absent ovary	absence of the female reproductive gland containing the germ cells
MP:0003579	increased ovarian carcinoma incidence	greater than the expected number of a malignant neoplasm arising from ovarian tissue, occurring in a specific population in a given time period
MP:0003580	increased fibroma incidence	greater than the expected number of a benign tumor of fibrous or fully developed connective tissue, in a specific population in a given time period
MP:0003581	increased ovarian fibroma incidence	greater than the expected number of a benign tumor of fibrous or fully developed connective tissue in the ovary, in a specific population in a given time period
MP:0003582	abnormal ovary development	abnormal morphogenesis of the ovarian follicle for the production of female germ cells or the endocrine cells for the production of estrogen and progesterone
MP:0003584	bifid ureter	two ureters join before draining into the urinary bladder; a duplex kidney with a bifid renal pelvis or bifid ureter ensues when a single ureteral bud bifurcates before the ampulla bifurcates
MP:0003585	large ureter	increased size or length of the tube that conducts the urine from the renal pelvis to the bladder
MP:0003586	dilated ureter	abnormal distention of one or both ureters due to accumulation of fluid
MP:0003587	ureter obstruction	a partial or total blockage in any part of the ureter causing obstruction of urine flow from the kidney to the urinary bladder; may be congenital, acquired, unilateral, bilateral, acute or chronic
MP:0003588	ureter stenosis	abnormal narrowing or constriction of the ureter
MP:0003589	abnormal ureter physiology	any functional anomaly of the tube that conducts the urine from the renal pelvis to the bladder
MP:0003590	OBSOLETE ureteral reflux	OBSOLETE retrograde movement of urine from the bladder to the kidney
MP:0003591	urethra atresia	closure, or failure to develop a connection in the canal that leads from the bladder and discharges urine externally
MP:0003592	urethra stricture	abnormal narrowing or constriction at one or more points in the urethra
MP:0003593	urethrovaginal fistula	an abnormal anatomical passage connecting the urethra and the vagina
MP:0003594	small urethra	decreased size or length of the canal that leads from the bladder and discharges urine externally
MP:0003595	epididymal cyst	presence of one or more benign growths in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0003596	epididymis inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0003597	increased epididymal cystadenoma incidence	greater than the expected number of a benign epithelial neoplasm with a glandular organization and a cyst-like appearance arising from epididymal tissue, occurring in a specific population in a given time period
MP:0003598	epispadia	congenital absence of the upper wall of the urethra, occurring in both sexes, but more often in the male, with the urethral opening somewhere on the dorsum of the penis at any point below the internal sphincter; in females, the malformed urethral opening is often located aberrantly
MP:0003599	large penis	enlarged size of the organ of copulation and urination in the male
MP:0003600	ectopic kidney	a kidney located outside of its normal position usually due to failed migration of the ureteral bud and developing metanephric blastema to the renal fossa; the most common example of renal ectopia is a pelvic kidney; other sites of ectopic kidneys include the iliac region, the abdomen, the chest, and, in some cases, the contralateral side, referred to as crossed
MP:0003601	bifid kidney	cleft of the kidney into two parts or branches, often having the appearance of two lobes
MP:0003602	increased renal hamartoma incidence	greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the kidney, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue
MP:0003603	increased renal hemangioblastoma incidence	greater than the expected number of a benign cyst-like tumor of the kidney that is composed of multiple capillary and sinusoidal channels lined with endothelial cells, occurring in a specific population in a given time period
MP:0003604	single kidney	presence of only one of the paired organs responsible for urine secretion
MP:0003605	fused kidneys	a defect in which there is a single malformed organ resulting from partial or complete fusion of the two renal anlage
MP:0003606	kidney failure	failure of the kidneys to adequately filter toxins and waste products from the blood; classified as acute (as in acute kidney injury) or chronic (as in chronic kidney disease); a number of other diseases or health problems may cause either form of renal failure to occur
MP:0003607	abnormal prostate gland physiology	any functional anomaly of the gland in males that secretes part of the seminiferous fluid
MP:0003608	prostate gland inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the prostate
MP:0003609	small scrotum	reduced size of the external sac of skin that encloses the testes
MP:0003610	scrotum hyperplasia	increase in the number of normal cells in normal arrangement in the external sac of skin that encloses the testes, typically resulting in increased size
MP:0003611	scrotum hypoplasia	decrease in the number of normal cells in normal arrangement in the scrotum, typically resulting in decreased size
MP:0003612	bifid scrotum	cleft of the scrotum into two parts or branches, often having the appearance of two lobes
MP:0003613	abnormal kidney medulla development	anomaly in the differentiation of the inner portion of the kidney consisting of the renal pyramids
MP:0003614	urinary bladder prolapse	hernial protrusion of the urinary bladder, usually through the vaginal wall
MP:0003615	urinary bladder diverticulum	a pouch or sac protruding from the urinary bladder wall
MP:0003616	abnormal urachus morphology	any structural anomaly of the fibrous remnant of the allantoic stalk, a narrow fetal canal connecting the apex of the urinary bladder with the umbilicus located in the space of Retzius, between the transversalis fascia anteriorly and the peritoneum posteriorly. its lumen is normally obliterated during development, transforming the urachus into a solid cord, a functionless remnant that persists throughout life as the median umbilical ligament; failure of complete lumen obliteration may result in distinct congenital urachal remnant anomalies
MP:0003617	urinary bladder hypoplasia	decrease in the number of normal cells in normal arrangement in the urinary bladder, typically resulting in decreased size
MP:0003618	uterine cervical atresia	narrowing of the cervical opening
MP:0003619	abnormal urine color	any alteration from the usual straw-coloration of the urine
MP:0003620	oliguria	a reduction in the volume of urine produced and excreted; however, some urine is still produced
MP:0003621	dysuria	difficult or painful urination
MP:0003622	ischuria	upon urination, some urine is retained in the bladder instead of being excreted
MP:0003623	hydrocele	accumulation of fluid around testes
MP:0003624	anuria	inability to form or excrete urine
MP:0003625	kidney medulla hyperplasia	increase in the number of normal cells in normal arrangement in the kidney medulla, typically resulting in increased size
MP:0003626	kidney medulla hypoplasia	decrease in the number of normal cells in normal arrangement in the kidney medulla, typically resulting in decreased size
MP:0003627	abnormal leukocyte tethering or rolling	anomaly in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation
MP:0003628	abnormal leukocyte adhesion	anomaly in the number of or process by which leukocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel
MP:0003630	abnormal urothelium morphology	any structural anomaly of the epithelial lining of the lumen of the organs of the urinary tract
MP:0003631	nervous system phenotype	the observable morphological and physiological characteristics of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that are manifested through development and lifespan
MP:0003632	abnormal nervous system morphology	any structural anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions
MP:0003633	abnormal nervous system physiology	any functional anomaly of the extensive, intricate network of electochemical structures in the body that is comprised of the brain, spinal cord, nerves, ganglia and parts of the receptor organs that receive and interpret stimuli and transmit impulses to effector organs to control body functions
MP:0003634	abnormal glial cell morphology	any structural anomaly of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons
MP:0003635	abnormal synaptic transmission	defect in the communication from a neuron to a target across a synapse
MP:0003636	obsolete absence of hair cells	OBSOLETE. absence of the sensory epithelial cells of the inner ear
MP:0003637	cochlear ganglion hypoplasia	decrease in the number of normal cells in normal arrangement in the cochlear ganglion, typically resulting in decreased size
MP:0003638	abnormal response/metabolism to endogenous compounds	altered ability or inability to metabolize or respond to substances normally present in the body
MP:0003639	abnormal response to vitamins	altered ability or inability to respond to or metabolize a group of organic substances that are required in trace amounts for the normal metabolic homeostasis of the body
MP:0003641	small lung	reduced size of the lung compared to controls
MP:0003642	absent seminal vesicle	absence of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0003643	spleen atrophy	acquired diminution of the size of the spleen associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0003644	thymus atrophy	acquired diminution of the size of the thymus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0003645	increased pancreatic beta cell number	greater than normal number of the cells of the pancreas that secrete insulin
MP:0003646	increased muscle fatigability	increased muscle exhaustion or increased susceptibility to muscle exhaustion
MP:0003647	absent oligodendrocytes	absence of the neuroglia of the central nervous system that form the insulating myelin sheath of axons in the CNS
MP:0003648	abnormal radial glial cell morphology	any structural anomaly of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult
MP:0003649	decreased heart right ventricle size	less than average size of the right ventricle compared to the average for a particular population
MP:0003651	abnormal axon extension	abnormality in the ability of an axon to exhibit long distance growth of a single axon process from a neuron cell body involved in cellular development
MP:0003652	abnormal skin turgor	anomaly in the ability of the skin to resist deformation; influential factors include dehydration and age
MP:0003653	decreased skin turgor	reduced ability of the skin to resist deformation; influential factors include dehydration and age
MP:0003654	nasal bone hyperplasia	increase in the number of normal cells in normal arrangement in the bone that forms the nasal bridge, typically resulting in increased size
MP:0003655	absent pancreas	absence of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream
MP:0003656	abnormal erythrocyte physiology	aberrant measurable or observable characteristic related to the function of or processes in the cells in the blood that carry oxygen, red blood cells
MP:0003657	abnormal erythrocyte osmotic lysis	increase or decrease in the ability of RBCs to withstand changes in osmolarity
MP:0003658	abnormal capillary morphology	any structural anomaly of the small branching blood vessels that form a network between the arterioles and venules, where the exchange of water, oxygen, carbon dioxide, and other nutrient and waste chemical substances occurs between the blood and the surrounding tissues
MP:0003659	abnormal lymph circulation	abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system
MP:0003660	chylothorax	an accumulation of chyle in the pleural space; chyle is fluid consisting of lymph and emulsified fats that is formed in the small intestine during digestion of fatty foods and taken up by the lymph vessels
MP:0003661	abnormal locus ceruleus morphology	any structural anomaly of a dense cluster of neurons within the dorsorostral pons; it is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic
MP:0003662	abnormal long bone epiphyseal plate proliferative zone	any anomaly of the germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix
MP:0003663	abnormal thermosensation	defect in the ability to sense or display a preference for a given temperature
MP:0003664	ocular pterygium	abnormal mass of hypertrophied bulbar subconjunctival tissue arising from the conjunctiva of the inner corner of the eye that obstructs vision by growing over the cornea towards the pupil
MP:0003665	endophthalmitis	inflammation of the internal structures of the tissues in the eyeball
MP:0003666	impaired sperm capacitation	reduced ability or inability of spermatozoa to undergo the series of morphological and molecular maturational processes in the female genital tract that enable them to penetrate and fertilize an egg
MP:0003667	increased hemangiosarcoma incidence	higher than normal incidence of a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding
MP:0003668	abnormal periodontal ligament morphology	any structural anomaly of the fibrous connective tissue that surrounds the root of a tooth, separating it from and attaching it to the alveolar bone; normally extends from the base of the gingival mucosa to the fundus of the bony socket, and its main function is to hold the tooth in its socket
MP:0003669	periodontal ligament hypercellularity	increased cell density of the periodontal ligament
MP:0003670	dilated renal glomerular capsule	stretched or widened aperture of the expanded beginning of a nephron that contains the glomerulus
MP:0003671	abnormal eyelid aperture	any anomaly in the normal distance from one eyelid to the other, or closure of the eyes
MP:0003672	abnormal ureter development	any anomaly in the differentiation of the tube that conducts the urine from the renal pelvis to the bladder
MP:0003673	abnormal inguinal canal morphology	any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord in the male or the round ligament in the female, nerves and vessels pass from the pelvic cavity to the scrotum or labia majora, respectively
MP:0003674	oxidative stress	condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma
MP:0003675	kidney cyst	presence of one or more abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion
MP:0003677	abnormal ear lobe morphology	any structural anomaly in the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage
MP:0003678	absent ear lobes	missing the soft tissue at the base of the outer ear; consists of fat and fibrous tissue not reinforced by the auricular cartilage
MP:0003679	ear lobe hypoplasia	decrease in the number of normal cells in normal arrangement in the ear lobe, typically resulting in decreased size
MP:0003680	thick ear lobes	an increase in the fleshiness of the ear lobes
MP:0003681	protruding ear lobes	ear lobes that project outward
MP:0003682	linear crease in ear lobe	appearance of fold-like marks in the ear lobe
MP:0003683	prominent ear lobes	conspicuous appearance of the ear lobes
MP:0003684	abnormal inferior olivary complex morphology	any structural anomaly in the capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids; neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex and have been implicated in various functions, such as learning and timing of movements
MP:0003685	abnormal cardiac ganglion morphology	any structural anomaly of the parasympathetic ganglia of the cardiac plexus between the arch of the aorta and the bifurcation of the pulmonary artery
MP:0003686	abnormal eye muscle morphology	any structural anomaly of the muscles of the eye
MP:0003687	abnormal intraocular muscle morphology	any structural anomaly of the smooth muscles within the eye
MP:0003688	ophthalmoparesis	loss of strength in the muscles that control eye movement
MP:0003689	ophthalmoplegia	paralysis of the ocular muscles
MP:0003690	abnormal glial cell physiology	any functional anomaly of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons
MP:0003691	abnormal microglial cell physiology	any functional anomaly of the small, migratory, phagocytic, interstitial cells derived from myeloid progenitor cells and found in the parenchyma of the central nervous system; microglia are scavengers, engulfing dead cells and other debris, and in Alzheimer's disease, microglia are found associated with dying nerve cells and amyloid plaques
MP:0003692	xanthoma	a deposit of cholesterol rich material in a tissue, most often in the skin but also seen in tendons and in the brain
MP:0003693	abnormal blastocyst hatching	any anomaly of the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation
MP:0003694	failure of blastocyst to hatch from the zona pellucida	the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, fails to occur
MP:0003695	delayed blastocyst hatching from the zona pellucida	the hatching of the cellular blastocyst from the zona pellucida, the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, occurs later in development than expected
MP:0003696	abnormal zona pellucida morphology	any structural anomaly of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation
MP:0003697	absent zona pellucida	missing the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation
MP:0003698	abnormal male reproductive system physiology	any functional anomaly of the male organs associated with producing offspring
MP:0003699	abnormal female reproductive system physiology	any functional anomaly of the female organs associated with producing offspring
MP:0003700	abnormal oviduct transport	increased or decreased rate of passage of embryos or oocytes from the ovary to the uterus
MP:0003701	elevated level of mitotic sister chromatid exchange	increased number of crossovers between sister chromatids during mitosis resulting in increased numbers of reciprocal exchanges of DNA between the two chromosomes; normally crossover exchanges are supressed during mitosis and only occur in meiosis
MP:0003702	abnormal chromosome morphology	any structural anomaly of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information
MP:0003703	abnormal vestibulocochlear ganglion morphology	any structural anomaly of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia
MP:0003704	abnormal hair follicle development	any anomaly in the development of the tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open
MP:0003705	abnormal hypodermis morphology	any structural anomaly of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia; usually consisting primarily of a fatty layer and may also include a muscle layer and/or a fibrous layer, or it may occur as a membranous layer only, being nearly devoid of fat; it contains skin ligaments extending between the dermis and deep fascia, cutaneous nerves, and superficial vessels, with terminal branches passing into the skin layers
MP:0003706	abnormal cell nucleus count	absent or greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis or events leading to apoptosis
MP:0003707	increased cell nucleus count	greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis
MP:0003708	binucleate	two nuclei present per cell body when one is expected; often due to failed cytokinesis
MP:0003709	anucleate	absent nucleus of a cell body when one is expected; often due to events leading to apoptosis
MP:0003710	abnormal physiological neovascularization	anomalies in the development of new blood vessels in restoration of blood circulation during the healing process
MP:0003711	pathological neovascularization	the proliferation of blood vessels in abnormal tissues or in abnormal positions
MP:0003712	raised ear position	outer ears which are situated above the normal location
MP:0003713	abnormal ear rotation	outer ears that are positioned such that the ears are turned relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position
MP:0003714	absent platelets	lack of non-nucleated cells found in the blood and involved in blood coagulation
MP:0003715	posteriorly rotated ears	outer ears that are positioned such that the ears are turned backwards relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position
MP:0003716	anteriorly rotated ears	outer ears that are positioned such that the ears are turned forward relative to the anterior-posterior body axis, but the ears emerge from the head at the usual position
MP:0003717	pallor	an unnatural paleness to the skin, generally attributable to anemia
MP:0003718	maternal effect	expression of a phenotypic trait in a female animal's offspring that is dependent on the maternal genotype
MP:0003719	abnormal pericyte morphology	any structural anomaly of the connective tissue cells that occurs around capillaries or other small blood vessels
MP:0003720	abnormal neural tube closure	any anomaly in the last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline
MP:0003721	increased tumor growth/size	greater than expected development of tumorous growth when compared to controls
MP:0003722	absent ureter	missing the tube that conducts the urine from the renal pelvis to the bladder
MP:0003723	abnormal long bone morphology	any structural anomaly of the bones that consist of a tubular shaft (diaphysis) and two ends that are wider than the shaft (epiphysis); long bones include the femora, tibiae, and fibulae, and the humeri, radii, and ulnae of the limbs; metacarpals and metatarsals of the autopods, the phalanges of the digits, and the clavicles
MP:0003724	increased susceptibility to induced arthritis	more likely to be stricken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents
MP:0003725	increased autoantibody level	elevated level of antibodies to self-antigens present in the sera; often indicative of autoimmune disease
MP:0003726	decreased autoantibody level	reduced level of antibodies to self-antigens present in the sera
MP:0003727	abnormal retina layer morphology	any structural anomaly of any of the layers that make up the retina
MP:0003728	abnormal retina photoreceptor layer morphology	any structural anomaly of the photoreceptor layer
MP:0003729	abnormal photoreceptor outer segment morphology	any structural anomaly of the photoreceptor region that is rich in the visual pigment rhodopsin
MP:0003730	abnormal photoreceptor inner segment morphology	any structural anomaly of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0003731	abnormal retina outer nuclear layer morphology	any structural anomaly of the retinal layer that contains the nuclei and cell bodies of rods and cones
MP:0003732	abnormal retina outer plexiform layer morphology	any structural anomaly of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)
MP:0003733	abnormal retina inner nuclear layer morphology	any structural anomaly of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells
MP:0003734	abnormal retina inner plexiform layer morphology	any structural anomaly of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites
MP:0003735	cup-shaped ears	deeply concave appearance to the outer ear
MP:0003736	folded helix	the bending over of the upper cartilaginous rim of the outer ear
MP:0003737	ossification of pinnae	formation of bone in the outer ear, which is normally cartilaginous
MP:0003739	dense middle ear ossicles	thickening of the three small bones of the middle ear
MP:0003740	fusion of middle ear ossicles	union of the three small bones of the middle ear into a single structure
MP:0003741	tinnitus	persistent sensation of buzzing, ringing, clicking, or other noises in the ear
MP:0003742	narrow head	a shorter ear- to -ear distance resulting in the appearance of a thin face and a protruding nasal region
MP:0003743	abnormal facial morphology	any structural anomaly of the face
MP:0003744	obsolete abnormal orofacial morphology	any structural anomaly of the the mouth and the face
MP:0003745	abnormal oral mucosa morphology	any structural anomaly of the mucous membrane that lines the inside of the mouth and consists of stratified squamous epithelium termed oral epithelium and an underlying connective tissue termed lamina propria
MP:0003746	stomatitis	inflammation of the mucous lining of the mouth
MP:0003747	mouth mucosal ulcer	lesions through the mucous membrane of the mouth, usually associated with loss of tissue
MP:0003748	increased oral mucosa hemangioma incidence	greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the oral mucosa, occurring in a specific population in a given time period
MP:0003749	down-turned corners of mouth	the lateral points of the oral cavity opening appear in a lower position that the rest of the lips
MP:0003750	increased mouth tumor incidence	greater than the expected number of neoplasms in the mouth tissues, usually in the form of a distinct mass, in a specific population in a given time period
MP:0003751	oral leukoplakia	white patchy lesions of the mucous membranes of the oral cavity; often considered a precancerous condition
MP:0003752	increased oral papilloma incidence	greater than the expected number of benign tumors consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic epithelial cells in the oral cavity
MP:0003753	increased lip papilloma incidence	greater than the expected number of a benign epithelial tumor of the lip of the oral cavity, occurring in a specific population in a given time period
MP:0003754	increased gingival papilloma incidence	greater than the expected number of a benign epithelial tumor of the oral gum tissue
MP:0003755	abnormal palate morphology	any structural anomaly of the roof of the mouth in vertebrates formed anteriorly by a bony projection of the upper jaw (hard palate) and posteriorly by the fold of connective tissue (soft palate)
MP:0003756	abnormal hard palate morphology	any structural anomaly of the anterior part of the palate that is supported by and includes the palatal extensions of the maxillary and palatine bones in the adult
MP:0003757	high palate	greater distance upward to the roof of the oral cavity than usual
MP:0003758	narrow palate	abnormally slim shape to the roof of the oral cavity
MP:0003759	broad palate	abnormally wide shape to the roof of the oral cavity
MP:0003760	decreased palatal length	reduction in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge
MP:0003761	arched palate	abnormally concaved shape to the roof of the oral cavity
MP:0003762	abnormal immune organ physiology	any functional anomaly of the organs of the immune system
MP:0003763	abnormal thymus physiology	any functional anomaly of the primary lymphoid organ that is required for immune system development
MP:0003764	abnormal palatal length	any change in the average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge
MP:0003765	increased palatal length	greater than average distance of the deepest point in the midline of the palate relative to the midline point on the anterior crest of the alveolar gum pad ridge
MP:0003766	obsolete decreased palatal length	
MP:0003767	palate inflammation	local accumulation of fluid, plasma proteins and leukocytes in the palate
MP:0003768	palatal telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the palate
MP:0003769	abnormal lip morphology	any structural anomaly of the fleshy margins of the mouth
MP:0003770	lip ulcer	lesions through the mucous membrane of the inner surface of the lip
MP:0003771	abnormal lip shape	changes in the characteristic contours of the fleshy margins of the mouth
MP:0003772	lip pit	an abnormal hollow or depression in the fleshy margins of the mouth
MP:0003773	eclabion	an outward turning of the inner surface of the lip
MP:0003774	thick lip	lips having an abundance and often an excess of soft tissue
MP:0003775	thin lip	lips having a reduced amount of soft tissue
MP:0003776	lip atrophy	acquired diminution of the size of the lip tissue associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0003777	lip inflammation	local accumulation of fluid, plasma proteins and leukocytes in the lips
MP:0003778	lip telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the lip
MP:0003779	lip cyst	presence of one or more fluid-filled membranous sacs in one or both lips
MP:0003780	increased lip tumor incidence	greater than the expected number of abnormal rapidly proliferating cells in the lip, usually in the form of a distinct mass, occurring in a specific population in a given time period
MP:0003781	increased lip neuroma incidence	greater than the expected number of a tumor derived from nerve cells or fibers residing in the lip, occurring in a specific population in a given time period
MP:0003782	short lip	lip that does not extend fully to the normal placement and meet the opposite lip
MP:0003783	tented upper lip	an upper lip having an inverted V- shape
MP:0003784	thin lip vermilion border	reduced thickness of the line between the lip and the facial skin around the mouth
MP:0003785	lip mucosal nodules	small mass of tissue or aggregation of cells in the mucosal tissue of the inner lip
MP:0003786	premature aging	earlier than normal occurrence of the normal signs of aging
MP:0003787	abnormal imprinting	defects in the establishment of heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself
MP:0003788	obsolete abnormal interferon physiology	OBSOLETE. impairment or increase of the cellular release of any of the cytokines produced by T cells, fibroblasts and other cells in response to a challenge by a foreign agents such as viruses, bacteria, parasites and tumor cells
MP:0003789	increased osteosarcoma incidence	greater than the expected number of a malignant neoplasm derived form mesenchymal stem cells, osteoblasts or osteocytes, occurring in a specific population in a given time period; osteosarcoma is a highly invasive and destructive tumor rising in the skeleton with osteoid and immature woven bone
MP:0003790	absent CD4-positive, alpha-beta T cells	lack of the set of single-positive T cells that express CD4 on their surface
MP:0003791	abnormal minor salivary gland morphology	any structural anomaly of the smaller, largely mucus-secreting, exocrine glands of the oral cavity, consisting of the labial, buccal, molar, lingual, and palatine glands
MP:0003792	abnormal major salivary gland morphology	any structural anomaly of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands
MP:0003793	abnormal submandibular gland morphology	any structural anomaly of either of the large major salivary glands situated beneath the mandible
MP:0003794	delayed somite formation	late onset of the induction and/or differentiation of the somites
MP:0003795	abnormal bone structure	anomaly in the composite material or the layered arrangement of the bony endoskeleton of the body
MP:0003797	abnormal compact bone morphology	any structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae
MP:0003798	abnormal Harderian gland pigmentation	any anomaly in the coloring of the sebaceous gland located behind the eyeball in the orbit that excretes fluid that facilitates movement of the third eyelid, due to changes in the amount, shape, or distribution of cells producing pigment
MP:0003799	impaired macrophage chemotaxis	reduced diffusion or accumulation of macrophages in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions
MP:0003800	monodactyly	having only one toe or digit on each extremity
MP:0003801	obsolete deviant histocompatibility locus	OBSOLETE. deviation from the parental type of histocompatibility
MP:0003802	obsolete deviant class I histocompatibility locus	OBSOLETE. deviation from the parental type of class I histocompatibility
MP:0003803	obsolete deviant class II histocompatibility locus	OBSOLETE. deviation from the parental type of class II histocompatibility
MP:0003804	obsolete deviant minor histocompatibility locus	OBSOLETE. deviation from the parental type of minor histocompatibility
MP:0003805	obsolete deviant histocompatibility-related locus	OBSOLETE. deviation from the parental type of a histocompatibility-related locus
MP:0003806	abnormal nucleotide metabolism	any anomaly in the chemical reactions and pathways involving a nucleotide, including metabolic, catabolic and biosynthetic processes
MP:0003807	camptodactyly	permanent flexion of one or more digits; contractures may also be seen in the wrists and at the elbows
MP:0003808	increased atrioventricular cushion size	larger than normal mounds of embryonic connective tissue that bulge into the fetal atrioventricular canal
MP:0003809	abnormal hair shaft morphology	any structural anomaly of the cuticle, cortex and/or medulla of a hair
MP:0003810	abnormal hair cuticle	anomalies in the thin, smooth and glossy outer protective cell layer of hair shaft
MP:0003811	abnormal hair cortex morphology	any structural anomaly in the spindle shaped cells of the hair shaft that contains keratin fibrils and matrix
MP:0003812	abnormal hair medulla	anomalies of hair medullary cell formation and arrangement of the innermost core of the hair shaft
MP:0003813	abnormal hair follicle dermal papilla morphology	any structural anomaly of the mesodermal signaling center of the hair follicle consisting of closely packed specialized mesenchymal fibroblasts
MP:0003814	vascular smooth muscle hypoplasia	decrease in the number of normal cells in normal arrangement in the vascular smooth muscle, typically resulting in decreased size
MP:0003815	hairless	having no hair at any time throughout lifespan, generally referring to primary genetic hairlessness
MP:0003816	abnormal pituitary gland development	malformation or incomplete differentiation of the compound gland suspended from the base of the hypothalamus, which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin
MP:0003817	abnormal pituitary diverticulum morphology	any structural anomaly of a tubular outgrowth of ectoderm from the stomodeum of the embryo; the outgrowth grows toward the infundibular process of the diencephalon, around which it forms a cup-like mass, giving rise to the pars distalis and pars juxtaneuralis of the hypophysis
MP:0003818	abnormal eye muscle development	malformation or arrest of differentiation of the muscles of the eye
MP:0003819	increased left ventricle diastolic pressure	increase in the pressure in the left ventricle between heart beats when the heart is relaxed
MP:0003820	increased left ventricle systolic pressure	increase in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries
MP:0003821	decreased left ventricle diastolic pressure	decrease in the pressure in the left ventricle between heart beats when the heart is relaxed
MP:0003822	decreased left ventricle systolic pressure	decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries
MP:0003823	increased left ventricle developed pressure	increase in the difference between left ventricular systolic and diastolic pressures
MP:0003824	decreased left ventricle developed pressure	decrease in the difference between left ventricular systolic and diastolic pressures
MP:0003825	abnormal pillar cell morphology	any structural anomaly of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti
MP:0003826	abnormal Mullerian duct morphology	any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina
MP:0003827	abnormal Wolffian duct morphology	any structural anomaly of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and later develop into the ductus deferens in the male
MP:0003828	pulmonary edema	an accumulation of an excessive amount of serous fluid in the parenchyma and the alveoli via effusion of intravascular fluid from the pulmonary vascular bed
MP:0003829	impaired febrile response	reduced or absent febrile response to exogenous or endogenous pyrogens
MP:0003830	abnormal testis development	abnormal morphogenesis of the male reproductive gland containing the germ cells
MP:0003833	decreased satellite cell number	less than the normal number of unfused cells in muscle that play a role in muscle regeneration
MP:0003834	abnormal adrenergic chromaffin cell morphology	any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion
MP:0003838	abnormal milk ejection	anomaly of the milk ejection reflex in response to suckling during lactation
MP:0003839	abnormal insulin clearance	increase or decrease in the rate at which insulin is removed from the blood stream
MP:0003840	abnormal coronal suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones and the frontal bone
MP:0003841	abnormal lambdoid suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the superior border of the occipital bone and the posterior borders of the right and left parietal bones
MP:0003842	abnormal metopic suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the frontal bones from the sagittal suture to the root of the nose; it is visible in neonates and juveniles, but it is frequently obliterated in some adult organisms; in mice and rats, the posterior frontal (PF) suture, situated between the frontal bones, is analogous to the human metopic suture; the anterior landmark for the PF suture is the jugum limitans; the posterior landmark for the PF suture is the bregma
MP:0003843	abnormal sagittal suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the parietal bones
MP:0003844	abnormal squamoparietal suture morphology	any structural anomaly of the dense, fibrous connective tissue joint between the squamous part of the temporal bone and the inferior aspect of the parietal bone; posteriorly, the squamous suture becomes the parietomastoid suture where the mastoid process articulates with the parietal bone; anteriorly, the squamous suture extends towards the pterion
MP:0003845	abnormal decidualization	atypical cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation; this process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta; expected changes include the eosinophilic proliferation around arterioles after ovulation or progesterone action on endometrium which increases glandular epithelial secretion, stimulates glycogen accumulation in stromal cell cytoplasm, and promotes stromal vascularity (spiral arterioles) and edema
MP:0003846	matted coat	coat hairs sticks together to form clumps and does not lie flat
MP:0003847	disorganized lens bow	derangement of the area where the lens epithelium pushes into the lens proper and forms new lens fibers
MP:0003848	brittle hair	hair is susceptible to breakage
MP:0003849	greasy coat	fur is oily in appearance or texture
MP:0003850	abnormal thymocyte activation	anomaly in the process of producing activated thymocytes from naive thymocytes
MP:0003851	skeletal muscle interstitial fibrosis	formation of fibrous tissue within the interstices of skeletal muscle as a result of repair or a reactive process
MP:0003852	skeletal muscle necrosis	morphological changes resulting from pathological death of skeletal muscle tissue; usually due to irreversible damage
MP:0003853	dry skin	skin characterized by the lack of natural or normal moisture
MP:0003854	abnormal forelimb stylopod morphology	any structural anomaly of the proximal element of the forelimb including the humerus
MP:0003855	abnormal forelimb zeugopod morphology	any structural anomaly of the distal elements of the forelimb including the radius and ulna
MP:0003856	abnormal hindlimb stylopod morphology	any structural anomaly of the proximal element of the hindlimb including the femur
MP:0003857	abnormal hindlimb zeugopod morphology	any structural anomaly of the distal elements of the hindlimb including the tibia and fibula
MP:0003858	enhanced coordination	improved ability to execute integrated movements of muscle
MP:0003859	abnormal Harderian gland physiology	any functional anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents)
MP:0003860	abnormal carbon dioxide level	anomalous concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases
MP:0003861	abnormal nervous system development	impaired or altered growth of the components of the nervous system
MP:0003862	decreased aggression towards male mice	when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice
MP:0003863	decreased aggression towards mice	when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards other mice
MP:0003864	abnormal midbrain development	anomaly in the formation of or the patterning of the part of the brainstem developing from the middle of the three primary cerebral vesicles of the embryo
MP:0003865	lymph node inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the lymph nodes
MP:0003866	abnormal defecation	anomaly in the discharge of feces from the body
MP:0003867	increased defecation amount	increase in the amount of discharge of feces from the body
MP:0003868	abnormal feces composition	increase or decrease in the amount of compounds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces
MP:0003869	ectopic cartilage	positional abnormality of cartilage
MP:0003870	decreased urine glucose level	a reduced amount of glucose in the urine compared to the normal state
MP:0003871	abnormal myelin sheath morphology	any structural anomaly of the insulating envelope that surrounds nerve fibers or axons
MP:0003872	absent heart right ventricle	missing the lower right chamber of the heart
MP:0003873	pharyngeal arch hypoplasia	decrease in the number of normal cells in normal arrangement in the pharyngeal arches, typically resulting in decreased size
MP:0003874	absent pharyngeal arches	missing the transient structures of the embryo that develop into regions of the head, neck and ears
MP:0003875	abnormal hair follicle regression	abnormal length of time for the onset of catagen phase of the cyclic transformation of the hair follicle
MP:0003876	obsolete abnormal cerebral function	OBSOLETE. anomalous activity of the thin layer of grey matter on the surface of the cerebral hemisphere that develops from the telencephalon and folds into gyri that is responsible for higher mental functions
MP:0003877	abnormal serotonergic neuron morphology	any structural anomaly of the neurons that secrete serotonin
MP:0003878	abnormal ear physiology	any functional anomaly of the ear, not due to an anatomical defect
MP:0003879	abnormal hair cell physiology	any functional anomaly of the sensory epithelial cells of the inner ear
MP:0003880	abnormal central pattern generator function	any functional anomaly of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns
MP:0003881	abnormal nephron morphology	any structural anomaly of the filtering unit of the kidney that includes the renal corpuscle, proximal and distal convoluted tubules, and loop of Henle
MP:0003882	abnormal pulse pressure	anomaly in the difference between systolic and diastolic blood pressure
MP:0003883	enlarged stomach	increased size of the stomach
MP:0003884	decreased macrophage cell number	fewer than the normal numbers of macrophages
MP:0003885	abnormal rostral-caudal body axis extension	anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established
MP:0003886	abnormal embryonic epiblast morphology	any structural anomaly of the transient structure derived from the inner cell mass which lies above the hypoblast; the epiblast tissue gives rise to the three primary germ layers (ectoderm, definitive endoderm, and mesoderm) and to the extraembryonic mesoderm of the visceral yolk sac, the allantois, and the amnion
MP:0003887	increased hepatocyte apoptosis	increase in the number of hepatocytes undergoing programmed cell death
MP:0003888	liver hemorrhage	bleeding within the liver
MP:0003889	enhanced sensorimotor gating	amplification of the process by which inhibitory neural pathways filter multiple stimuli and allow attention to be focused on one stimulus; usually measured by pre-pulse inhibition (PPI)
MP:0003890	abnormal embryonic-extraembryonic boundary morphology	any structural anomaly in the delineating tissue and the segregation between the embryo proper and extraembryonic tissues
MP:0003891	increased allantois apoptosis	increase in the number of cells of the allantois undergoing programmed cell death
MP:0003892	abnormal gastric gland morphology	any structural anomaly of any of the branched tubular glands in the mucosa of the fundus and body of the stomach that contain parietal cells that secrete hydrochloric acid and zymogenic cells that produce pepsin
MP:0003893	increased hepatocyte proliferation	increase in the expansion rate of the hepatocyte cell population by cell division
MP:0003894	abnormal Purkinje cell innervation	any structural anomaly of the supply of nerve fibers that connect to the Purkinje cells
MP:0003895	increased ectoderm apoptosis	increase in the number of ectoderm cells undergoing programmed cell death during development
MP:0003896	prolonged PR interval	increase in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
MP:0003897	abnormal ST segment	anomaly in the length of time between the end of S-wave and the beginning of T-wave; reflects the amount of time the ventricles remain electrically depolarized
MP:0003898	abnormal QRS complex	anomaly in the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction
MP:0003899	abnormal QT interval	anomaly in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
MP:0003900	shortened QT interval	decrease in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time, and is measured from the beginning of the QRS complex to the end of the T wave
MP:0003901	abnormal PR interval	anomaly in the length of time between the beginning of atrial depolarization and the beginning of ventricular depolarization, measured by the interval from the beginning of the P wave to the beginning of the QRS complex
MP:0003902	abnormal cell mass	anomaly in the total physical bulk or volume of a cell compared to the normal state
MP:0003903	increased cell mass	greater total physical bulk or volume of a cell compared to the normal state
MP:0003904	decreased cell mass	reduction in the total physical bulk or volume of a cell compared to the normal state
MP:0003905	abnormal aorta elastin content	anomaly in the physical amount of elastin in the aorta compared to the normal state
MP:0003906	increased aorta elastin content	greater physical amount of elastin in the aorta compared to the normal state
MP:0003907	decreased aorta elastin content	reduction in the physical amount of elastin in the aorta compared to the normal state
MP:0003908	decreased stereotypic behavior	less frequent incidence of repetitive, invariant, persistent motor patterns that do not appear to be purposeful
MP:0003913	increased heart right ventricle weight	greater than average weight of the right ventricle compared to the average
MP:0003914	decreased heart right ventricle weight	less than average weight of the right ventricle compared to the average
MP:0003915	increased heart left ventricle weight	greater than average weight of the heart left ventricle compared to the average for a particular population
MP:0003916	decreased heart left ventricle weight	less than average weight of the heart left ventricle compared to the average for a particular population
MP:0003917	increased kidney weight	greater weight of the organs responsible for urine secretion
MP:0003918	decreased kidney weight	reduced weight of the organs responsible for urine secretion
MP:0003919	obsolete abnormal lymph node cellularity	OBSOLETE. anomaly in the cellular make up of the lymph nodes
MP:0003920	abnormal heart right ventricle morphology	any structural anomaly of the right lower chamber of the heart
MP:0003921	abnormal heart left ventricle morphology	any structural anomaly of the left lower chamber of the heart
MP:0003922	abnormal heart right atrium morphology	any structural anomaly of the right upper chamber of the heart
MP:0003923	abnormal heart left atrium morphology	any structural anomaly of the left upper chamber of the heart
MP:0003924	diaphragmatic hernia	protrusion of abdominal contents into the thoracic cavity through a hole in the diaphragm
MP:0003925	abnormal cellular glucose uptake	anomaly in the ability of a cell to take in glucose from the environment
MP:0003926	decreased cellular glucose uptake	reduced ability of a cell to take in glucose from the environment
MP:0003927	increased cellular glucose import	increased ability of a cell to take in glucose from the environment
MP:0003928	increased heart rate variability	increased variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle
MP:0003929	decreased heart rate variability	reduced variation of beat-to-beat intervals of the heart that occurs in conjunction with the respiratory cycle
MP:0003930	abnormal tooth hard tissue morphology	any structural anomaly of the hard portion of the tooth surrounding the pulp, including the dentin, enamel and the cementum on the root
MP:0003931	absent molars	absence of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface
MP:0003932	abnormal molar crown morphology	any structural anomaly of the part of a molar that is covered by enamel
MP:0003933	abnormal cementum morphology	any strucutral anomaly in the bonelike rigid connective tissue covering the root of a tooth
MP:0003934	abnormal pancreas development	anomaly in the formation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream
MP:0003935	abnormal craniofacial development	anomaly in the process of forming the face and/or cranium
MP:0003936	abnormal reproductive system development	developmental anomaly of any of the organs involved in the reproductive system
MP:0003937	obsolete abnormal limbs/digits/tail development	OBSOLETE. anomaly of the formation of the digits, autopod, limbs, or tail
MP:0003938	abnormal ear development	developmental anomaly of any of the structures involved in the ear or vestibular system
MP:0003939	abnormal myotome morphology	any structural anomaly of the mesoderm that is derived from the somite that is fated to become the musculature
MP:0003940	abnormal dermatome morphology	any structural anomaly in the mesoderm that is derived from the somite that is fated to become the dermis
MP:0003941	abnormal skin development	anomaly in the formation of the membranous protective covering of the body
MP:0003942	abnormal urinary system development	any anomaly in the differentiation of the organ system that produces, stores, and eliminates urine
MP:0003943	abnormal hepatobiliary system development	developmental anomaly of any of the tissues of the liver or biliary system
MP:0003944	abnormal T cell subpopulation ratio	deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples
MP:0003945	abnormal lymphocyte physiology	any functional anomaly of any of the white blood cells that includes B cells, T cells, and NK cells
MP:0003946	renal necrosis	morphological changes resulting from pathological death of renal tissue; usually due to irreversible damage
MP:0003947	abnormal cholesterol level	anomaly in the amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0003948	abnormal gas homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of gaseous elements in animal tissues or blood
MP:0003949	abnormal circulating lipid level	anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood
MP:0003950	abnormal plasma membrane morphology	any structural anomaly of the semi-permeable membrane that encloses the cytoplasm of a cell
MP:0003951	abnormal copper homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of copper that is a cofactor in a number of proteins including amine oxidases and chaperone proteins
MP:0003952	abnormal copper level	anomaly in the concentration in the body of the metallic element atom that has formula Cu, and normally occurs as a cofactor for a number of proteins including amine oxidases and chaperone proteins
MP:0003953	abnormal hormone level	aberrant tissue or circulating concentration of any substance, usually a peptide or steroid, that has a specific metabolic regulatory effect on the activity or behavior of cells expressing a receptor for the hormone
MP:0003954	abnormal Reichert's membrane morphology	any structural anomaly of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm; required for the maternofetal exchange of nutrients and is important for the postgastrulation development
MP:0003955	abnormal ultimobranchial body morphology	any structural anomaly of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth
MP:0003956	abnormal body size	anomaly in the average body weight, height and/or length of an organism compared to controls
MP:0003957	abnormal nitric oxide homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of nitric oxide, a free radical gas and a potent vasodilator
MP:0003958	heart valve hyperplasia	increase in the number of normal cells in normal arrangement in any of the heart valves, typically resulting in increased size
MP:0003959	abnormal lean body mass	anomaly in the amount of the fat-free physical bulk or volume of the body including all its components except adipose tissue
MP:0003960	increased lean body mass	greater amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue
MP:0003961	decreased lean body mass	reduced amount of the fat-free physical bulk or volume of the body including all its components except adipose (fat) tissue
MP:0003962	abnormal adrenaline level	aberrant concentration in the blood or tissues of this catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0003963	abnormal corticosterone level	anomalous blood or tissue amount of an adrenocortical steroid that induces glycogen deposition and regulates sodium conservation and potassium secretion
MP:0003964	abnormal noradrenaline level	aberrant amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine
MP:0003965	abnormal pituitary hormone level	aberration in the blood or tissue concentration of any of the hormones secreted by the pituitary
MP:0003966	abnormal adrenocorticotropin level	anomaly in the level of the pituitary hormone that stimulates the secretion of adrenal cortical steroids and induces growth of the adrenal cortex
MP:0003967	abnormal follicle stimulating hormone level	anomalous concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0003968	abnormal growth hormone level	anomalous concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization
MP:0003969	abnormal luteinizing hormone level	aberrant levels in the bloodstream of LH, the hormone that regulates steroid production by the interstitial cells of the testis and the ovary
MP:0003970	abnormal prolactin level	anomalous concentration of the hormone that stimulates milk secretion
MP:0003971	abnormal thyroid-stimulating hormone level	anomalous concentration of the hormone that stimulates the growth and function of the thyroid gland
MP:0003972	decreased pituitary hormone level	less than the expected amount of any of the pituitary hormones in the blood or tissues
MP:0003973	increased pituitary hormone level	greater than the expected amount of any of the pituitary hormones in the blood or tissues
MP:0003974	abnormal endocardium morphology	any structural anomaly of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart
MP:0003975	increased circulating VLDL triglyceride level	higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue
MP:0003976	decreased circulating VLDL triglyceride level	lower than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue
MP:0003977	abnormal circulating carnitine level	aberrant concentration in the blood of carnitine, a quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane
MP:0003978	decreased circulating carnitine level	lower than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane
MP:0003979	increased circulating carnitine level	greater than normal blood concentration of this quaternary ammonium amino acid derivative involved in transport of fatty acids across the mitochondrial membrane
MP:0003980	increased circulating phospholipid level	greater concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group
MP:0003981	decreased circulating phospholipid level	reduced concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group
MP:0003982	increased cholesterol level	greater than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0003983	decreased cholesterol level	less than normal amount in the body of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0003984	embryonic growth retardation	slow or limited development during the embryonic period (sensu Mus: up to E14, or the completion of organogenesis)
MP:0003985	renal fibrosis	formation of fibrous tissue in the kidney as a result of repair or a reactive process
MP:0003986	small cochlear ganglion	reduced size of the cochlear ganglion or of the sensory neuron cell bodies that conveys auditory sensation from the organ of Corti to the hindbrain and resides on the cochlear part of the vestibulocochlear nerve (eighth cranial nerve)
MP:0003987	small vestibular ganglion	reduced size of the vestibular ganglion or of the sensory neuron cell bodies associated with the eighth cranial nerve
MP:0003988	disorganized embryonic tissue	a lack of the regular arrangement of any embryonic tissues
MP:0003989	abnormal barrel cortex morphology	any structural anomaly of the discrete functional units of the somatosensory cortex that processes tactile information derived from the vibrissae
MP:0003990	decreased neurotransmitter release	reduced production or release of endogenous signaling molecules normally secreted by neurons that alter the behavior of neurons or effector cells
MP:0003991	arteriosclerosis	thickening, hardening and/or loss of elasticity of the walls of arteries
MP:0003992	increased mortality induced by ionizing radiation	greater sensitivity to doses of ionizing radiation that include ultraviolet light, X-rays, or gamma rays, resulting in death
MP:0003993	abnormal ventral spinal root morphology	any structural anomaly of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves
MP:0003994	abnormal dorsal spinal root morphology	any structural anomaly of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves
MP:0003995	abnormal uterine artery morphology	any structural anomaly of the branch of the internal iliac artery that supplies the uterus and the upper part of the vagina
MP:0003996	clonic seizures	increased number or decreased threshold for the induction of a seizure characterized by unilateral or bilateral rhythmic jerking movements of the arms and legs caused by alternating contraction and relaxation of muscle
MP:0003997	tonic-clonic seizures	increased number or decreased threshold for the induction of a seizure characterized by initial rigidity followed by rhythmic jerking movements
MP:0003998	decreased thermal nociceptive threshold	a lower than average point at which thermal pain sensation is first detectable
MP:0003999	enhanced passive avoidance behavior	increase in the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously
MP:0004000	impaired passive avoidance behavior	decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously
MP:0004001	decreased hepatocyte proliferation	reduction in the expansion rate of the hepatocyte cell population by cell division
MP:0004002	abnormal jejunum morphology	any structural anomaly of the portion of the small intestine that extends from the duodenum to the ileum
MP:0004003	abnormal vascular endothelial cell physiology	anomaly in the function of the cells that line the vasculature
MP:0004004	patent ductus venosus	failure of the embryonic connection between the portal vein and inferior vena cava formed by the left umbilical vein (that allows oxygenated blood to bypass the developing liver) to close in adults
MP:0004005	impaired contractility of intestinal smooth muscle	inability or reduced ability of intestinal smooth muscle to shorten or to develop increased tension
MP:0004006	impaired contractility of jejunal smooth muscle	inability or reduced ability of the jejunal smooth muscle to shorter or to develop increased tension
MP:0004007	abnormal lung vasculature morphology	any structural anomaly of the blood vessels of the lung
MP:0004008	abnormal GABA-mediated receptor currents	change in the measured amplitude, current density or duration of response to stimulation of GABA receptors
MP:0004009	abnormal diastolic filling velocity	anomaly in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders
MP:0004010	increased diastolic filling velocity	greater rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders
MP:0004011	decreased diastolic filling velocity	reduction in the rate of fluid inflow to the heart during diastole compared to controls; usually measured in the left ventricle; altered filling velocity often contributes to various cardiovascular disorders
MP:0004012	increased pulmonary artery pressure	increased pulmonary pressure compared to controls
MP:0004013	decreased pulmonary artery pressure	reduced pulmonary pressure compared to controls
MP:0004014	abnormal uterine environment	anomaly or inability of the uterus to support embryonic development
MP:0004015	abnormal oviduct environment	anomaly or inability of the oviduct to support egg viability
MP:0004016	decreased bone mass	a reduction in the total amount of bone tissue contained in the skeleton
MP:0004017	duplex kidney	a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally
MP:0004018	abnormal galactose homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of galactose in the fluids and tissues
MP:0004019	abnormal vitamin homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of organic substances found in food and are not synthesized by the body and are necessary in trace amounts for normal metabolic function
MP:0004020	polyhydramnios	abnormally high amniotic fluid volume; may result from maternal diabetes, chromosomal abnormalities or other congenital abnormalities
MP:0004021	abnormal rod electrophysiology	any functional anomaly of dark adapted vision mediated by the rods
MP:0004022	abnormal cone electrophysiology	any functional anomaly of light adapted vision mediated by the cones
MP:0004023	abnormal chromosome number	chromosome count is other than the expected diploid chromosome number
MP:0004024	aneuploidy	chromosome count is not an exact multiple of the haploid number
MP:0004025	polyploidy	more than two chromosome sets are present
MP:0004026	monosomy	one chromosome missing from an otherwise diploid chromosome set
MP:0004027	trisomy	presence of an extra chromosome in an otherwise diploid chromosome set
MP:0004028	chromosome breakage	chromosome instability in the form of increased frequency of spontaneous breakage with or without rearrangements
MP:0004029	spontaneous chromosome breakage	chromosome breakage due to inherent instability of chromosomes
MP:0004030	induced chromosome breakage	chromosome breakage following treatment with a DNA-damaging agent
MP:0004031	insulitis	a histological change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells
MP:0004032	abnormal interventricular groove morphology	any structural anomaly of the indentation dividing the two ventricles, comprised of the sulcus interventricularis anterior and the sulcus interventricularis posterior
MP:0004033	supernumerary teeth	presence of a supernumerary, i.e., extra, tooth or teeth
MP:0004034	belly blaze	the appearance of a stripe or zigzag of white fur on the ventrum
MP:0004035	abnormal sublingual gland morphology	any structural anomaly of the small mucin-producing salivary glands in the floor of the mouth beneath the tongue, anterior to the submandibular gland
MP:0004036	abnormal muscle relaxation	altered ability of the muscle to lengthen following contractions
MP:0004037	increased muscle relaxation	greater than the normal ability of the muscle to lengthen following contractions or increase in the ability of the muscle to lengthen following contractions
MP:0004038	lymphangiectasis	stretched or widened aperture of the luminal space of one or more of the lymphatic vessels
MP:0004039	abnormal cardiac muscle cell glucose uptake	anomalous ability of the cells of the heart muscle to take in glucose
MP:0004040	abnormal susceptibility to kidney reperfusion injury	a change in the likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia
MP:0004041	increased susceptibility to kidney reperfusion injury	an increased likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia
MP:0004042	decreased susceptibility to kidney reperfusion injury	a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia
MP:0004043	abnormal pH regulation	anomaly in the function of the buffer systems of the body in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the body, as measured by the concentration of hydrogen ion
MP:0004044	aortic dissection	a pathologic process, characterized by splitting of the media layer of the aorta, which leads to formation of a dissecting aneurysm
MP:0004045	abnormal cell cycle checkpoint function	anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable
MP:0004046	abnormal mitosis	anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis)
MP:0004047	abnormal milk composition	anomaly in one or more of the constituents of milk including protein, lipid, and/or mineral content or in the appearance of milk
MP:0004048	obsolete increased resistance to addictive substance	OBSOLETE. increased threshold to obtain a physiological or behavioral response to an addictive substance
MP:0004049	increased acute promyelocytic leukemia incidence	higher than normal incidence of cancer characterized by rapid onset of abnormal leukocyte proliferation, manifesting as a severe bleeding disorder from coagulation abnormalities, and bone marrow infiltration of abnormal promyelocytes and myelocytes
MP:0004050	abnormal renal sympathetic nerve activity	any anomaly in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function
MP:0004051	increased renal sympathetic nerve activity	elevation in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function
MP:0004052	decreased renal sympathetic nerve activity	reduction in the stimulation transmitted by the sympathetic nerves to the kidneys that is primarily adrenergic and modifies kidney function
MP:0004053	abnormal synchondrosis	anomalous or persistent cartilaginous fusion of two bones
MP:0004054	abnormal periocular mesenchyme morphology	any structural anomaly of the mesenchymal cells that give rise to the corneal endothelium, corneal stroma, sclera, iris stroma, ciliary muscle, ciliary stroma, and trabecular meshwork of the eye
MP:0004055	heart atrium hypoplasia	decrease in the number of normal cells in normal arrangement in the heart atrium, typically resulting in decreased size
MP:0004056	abnormal myocardium compact layer morphology	any structural anomaly of the outer, dense layer of the myocardium uniting the epicardium and myocardium
MP:0004057	thin myocardium compact layer	reduced thickness of the outer, dense layer of the myocardium
MP:0004058	abnormal ventricle papillary muscle morphology	any structural anomaly of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle
MP:0004060	absent papillary muscle	absence of one of the group of myocardial bundles which terminate in the chordae tendineae that attach to the cusps of the atrioventricular valves; each ventricle has an anterior and a posterior papillary muscle; the right ventricle sometimes has a septal papillary muscle
MP:0004061	papillary muscle hypoplasia	decrease in the number of normal cells in normal arrangement in the papillary muscle, typically resulting in decreased size
MP:0004062	dilated heart right atrium	the luminal space of the right upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid
MP:0004063	dilated heart left atrium	the luminal space of the left upper chamber of the heart is increased in volume or area, usually with an increase in contained fluid
MP:0004064	decreased susceptibility to induced muscular atrophy	less than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)
MP:0004065	increased susceptibility to induced muscular atrophy	greater than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)
MP:0004066	abnormal primitive node morphology	any structural anomaly of the regional thickening of cells at the rostral tip of the vertebrate primitive streak through which gastrulating cells migrate anteriorly to form tissues in the future head and neck; this region organizes the formation of the three embryonic layers and establishes the longitudinal axis and the polarity of the embryo
MP:0004067	abnormal trabecula carnea morphology	any structural anomaly of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart
MP:0004068	dilated dorsal aorta	stretched or widened aperture of the luminal space of one or both of the pair of arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation
MP:0004069	abnormal muscle spindle morphology	any structural anomaly of the sensory organs in muscle that are involved in the stretch reflex
MP:0004070	abnormal P wave	any anomaly in the P wave which represents atrial depolarization and corresponds to electrical impulses rather than mechanical atria contractions; irregular or absent P waves may indicate arrhythmia and the shape of the P waves may indicate atrial problems
MP:0004071	prolonged P wave	increase in the length of time of the P wave electrical impulses, measured from the beginning to the end of the P wave
MP:0004072	abnormal frontal plane axis	any anomaly found in the sum of all electrical currents in the heart during systole
MP:0004073	caudal body truncation	caudal part of body truncated; typically with the rostral portion of the body relatively normal
MP:0004074	abnormal Schwann cell precursor morphology	any structural anomaly of the progenitors of cells that sheath the axons of the peripheral nervous system
MP:0004075	decreased Schwann cell precursor number	fewer numbers than normal of the progenitors of cells that sheath the axons of the peripheral nervous system
MP:0004076	abnormal vitelline vascular remodeling	anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network
MP:0004077	abnormal striatum morphology	any structural anomaly of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking
MP:0004078	abnormal caudate nucleus morphology	any structural anomaly of one or both C-shaped structures that border the lateral ventricle wall and contain input neurons involved with control of voluntary movement in the brain
MP:0004079	abnormal putamen morphology	any structural anomaly of the lens-shaped basal ganglion involved with control of voluntary movement in the brain
MP:0004080	abnormal nucleus accumbens morphology	any structural anomaly of the group of neurons located at the head of the caudate nucleus and anterior to the putamen; these neurons normally are involved in sensations of pleasure and reactions to addictive substances
MP:0004081	abnormal globus pallidus morphology	any structural anomaly of one of the basal ganglia involved with control of voluntary movement in the brain; consists of an external and an internal segment
MP:0004082	abnormal habenula morphology	any structural anomaly in the group of nuclei that makes up the small eminence on the dorsomedial surface of the thalamus, just in front of the dorsal commissure on the lateral edge of the habenular trigone
MP:0004083	polysyndactyly	greater than the normal complement of digits present on an autopod with interdigital webbing also present
MP:0004084	abnormal cardiac muscle relaxation	altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min
MP:0004085	abnormal heartbeat	anomaly in the appearance of regularly spaced contractions of the heart due to defects in the frequency, rate, pattern or extent of heart contraction
MP:0004086	absent heartbeat	lack of a spontaneously beating heart (usually due to defects in the calcium delivery mechanism or loss of a functional contractile apparatus)
MP:0004087	abnormal muscle fiber morphology	any structural anomaly of the muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated
MP:0004088	abnormal sarcoplasmic reticulum morphology	any structural anomaly in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere
MP:0004089	dilated sarcoplasmic reticulum	an expansion in the volume in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere
MP:0004090	abnormal sarcomere morphology	any structural anomaly in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle
MP:0004091	abnormal Z line morphology	any structural anomaly in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere
MP:0004092	absent Z line	missing the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere
MP:0004093	diffuse Z line	widely spread cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere
MP:0004094	abnormal M line morphology	any structural anomaly of the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments
MP:0004095	ocular distichiasis	presence of a double row of eyelashes on an eyelid, one or both of which are turned in against the eyeball
MP:0004096	abnormal midbrain-hindbrain boundary development	anomaly in the formation of the midbrain-hindbrain domain, comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages; an organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate
MP:0004097	abnormal cerebellar cortex morphology	any structural anomaly of the thin mantle of grey matter that covers the surface of each cerebral hemisphere, including the six layers of nerve cells and the nerve pathways that connect them; together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function
MP:0004098	abnormal cerebellar granule cell morphology	any structural anomaly of the small neurons of the cerebellar granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites
MP:0004099	abnormal cerebellar glomerulus morphology	any structural anomaly of an intertwined cluster of nerve fibers surrounded by glia where mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons
MP:0004100	abnormal spinal cord interneuron morphology	any structural anomaly of neurons that exclusively interact with other neurons in the spinal cord
MP:0004101	abnormal brain interneuron morphology	any structural anomaly of neurons that exclusively interact with other neurons in the brain; this includes most brain neuronal cell types
MP:0004102	abnormal dorsal striatum morphology	any structural anomaly of the regions of the caudate nucleus and the putamen that lie dorsal to the anterior commissure
MP:0004103	abnormal ventral striatum morphology	any structural anomaly of the regions of the nucleus accumbens and some nuclei of the olfactory tubercle that lie ventral to the anterior commissure
MP:0004105	cornea abrasion	scraping away or denuding of the corneal surface
MP:0004106	lymphatic vessel hyperplasia	increase in the number of normal cells in normal arrangement in the lymphatic vessels, typically resulting in increased size
MP:0004107	abnormal thoracic duct morphology	any structural anomaly in the largest collecting lymph vessel in the body, beginning at the cisterna chyli at about the level of the second lumbar vertebra, and drains into the systemic (blood) circulation at the left brachiocephalic vein between the left subclavian and left internal jugular veins
MP:0004108	abnormal esophageal peristalsis	altered esophageal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls that move the esophagus contents forward
MP:0004109	abnormal Sertoli cell development	anomalous differentiation of cells that support germ cell differentiation in males
MP:0004110	transposition of great arteries	cardiovascular structural anomaly in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle
MP:0004111	abnormal coronary artery morphology	any structural anomaly of any of the arteries that branch from the ascending aorta to supply blood to the heart
MP:0004112	abnormal arteriole morphology	any structural anomaly of the small diameter vessels that branch from the arteries and lead to the capillaries
MP:0004113	abnormal aortic arch morphology	any structural anomaly of the convex portion of the aorta between the ascending and descending parts of the aorta; branches from it include the brachiocephalic trunk, the left common carotid artery, and the left subclavian artery; the brachiocephalic trunk further splits to form the right subclavian artery and the right common carotid artery
MP:0004114	abnormal atrioventricular node morphology	any structural anomaly of the small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus; this node gives rise to the electrical connection between the atria and ventricles and responds to the sinoatrial node
MP:0004115	abnormal sinoatrial node morphology	any structural anomaly of the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atrium that is the source of contraction impulses for the heart
MP:0004116	abnormal atrioventricular bundle conduction	anomaly in the transfer of cardiac electrical impulses through the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle
MP:0004117	abnormal atrioventricular bundle morphology	any structural anomaly of the specialized cardiac muscle fibers that originates in the atrioventricular node and extends into the ventricle
MP:0004118	abnormal baroreceptor morphology	any structural anomaly in the sensory nerve endings in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure
MP:0004119	hypokalemia	excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection
MP:0004120	cardiac ischemia	inadequate blood flow to the heart; may cause infarction and is usually caused by coronary artery disease
MP:0004121	abnormal sarcolemma morphology	any structural anomaly in the plasma membrane of a muscle fiber that is capable of conducting electrical impulses
MP:0004122	abnormal sinus arrhythmia	any anomaly in the normal phenomenon of mild acceleration and slowing of the heart rate that occurs during the respiratory cycle
MP:0004123	abnormal impulse conducting system morphology	any structural anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart
MP:0004124	abnormal Purkinje fiber morphology	any structural anomaly in the cardiac muscle fibers composing the terminal portion of the heart conduction system located in the ventricle
MP:0004125	abnormal venule morphology	any structural anomaly of the minute vessels that collect deoxygenated blood from the capillary plexuses returns it to the veins
MP:0004126	thin hypodermis	reduced thickness of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia
MP:0004127	thick hypodermis	increase in the width of the irregular layer of loose connective tissue containing fibroblasts, adipose cells, and macrophages, that is immediately deep to the skin and superficial to the deep fascia
MP:0004129	abnormal respiratory quotient	anomaly in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls
MP:0004130	abnormal muscle cell glucose uptake	anomaly in the ability of muscle cells to take in glucose
MP:0004131	abnormal motile primary cilium morphology	any structural anomaly of the cilia of the embryo found on the cells of the embryonic node, which generate flow of extraembryonic fluid surrounding the node in a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization
MP:0004132	absent embryonic cilia	absence of cilia on the cells of the embryonic node
MP:0004133	heterotaxia	abnormal arrangement of organs or parts of the body in relation to each other according to the left-right axis
MP:0004134	abnormal chest morphology	any structural anomaly of the part of the body between the neck and the abdomen
MP:0004135	abnormal mammary gland embryonic development	aberration in the differentiation of the mammary gland during early embryogenesis
MP:0004136	abnormal tongue muscle morphology	any structural anomaly of the muscular portion of the tongue
MP:0004137	abnormal gastric surface mucous cell morphology	any structural anomaly of the mucus secreting epithelial cells that line the luminal surface of the stomach and the gastric pits which secrete mucus and HCO3- to protect the gastric surface from the acidic environment of the stomach
MP:0004138	abnormal mucous neck cell morphology	any structural anomaly of the mucin-producing epithelial cells present in the neck of the gastric glands
MP:0004139	abnormal gastric parietal cell morphology	any structural anomaly of the gastric acid producing epithelial cells that are distributed throughout the length of the gastric gland
MP:0004140	abnormal gastric chief cell morphology	any structural anomaly of the pepsinogen producing epithelial cells that are clustered at the base of the gastric gland
MP:0004141	abnormal enteroendocrine cell morphology	any structural anomaly of the various hormone- or neurotransmitter-secreting epithelial cells present throughout the mucosa of the digestive tract
MP:0004142	abnormal muscle tone	anomaly in the resting tautness or laxity of a muscle, normally somewhere in the middle of the range between total contraction and total relaxation
MP:0004143	muscle hypertonia	increased muscle tension resulting in stiffness of the muscles in the resting state
MP:0004144	hypotonia	decreased muscle tension resulting in limpness of the muscles in the resting state, not to be confused with weakness
MP:0004145	abnormal muscle electrophysiology	any functional anomaly of the musculature as it relates to electrical phenomena
MP:0004146	absent M line	missing the band in the center of the H band that contains proteins that crosslink the thick filament system (myosins) and the M-band part of the elastic filaments
MP:0004147	increased porphyrin level	elevated concentration of porphyrins or protoporphyrins
MP:0004148	increased compact bone thickness	thicker than normal superficial layer of compact bone
MP:0004149	increased bone strength	increased ability of bone to endure the application of force without yielding or breaking
MP:0004150	absent caveolae	absence of the small pockets, vesicles, caves, or recesses communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane
MP:0004151	decreased circulating iron level	less than the normal concentration of iron in the blood
MP:0004152	abnormal circulating iron level	anomalous blood concentration of the metallic element that normally occurs in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes
MP:0004153	increased renal tubule apoptosis	increase in the number of renal tubule cells undergoing programmed cell death
MP:0004154	renal tubular necrosis	morphological changes resulting from pathological death of renal tubular tissue; usually due to irreversible damage
MP:0004155	decreased susceptibility to induced pancreatitis	reduced or absent inflammatory response in the pancreatic tissue after experimental manipulation
MP:0004156	abnormal QT variability	anomaly in the index of beat-to-beat QT interval fluctuations (temporal QT interval variability), normally expressed as a unitless negative number reflecting beat-to-beat changes in ventricular repolarization; an increased, positive QTVI number indicates significant repolarization abnormalities
MP:0004157	interrupted aortic arch	complete discontinuation between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery
MP:0004158	right aortic arch	the aortic arch lies to the right of the trachea and esophagus; results from persistence of the entire right dorsal arch and involution of a segment of the left arch
MP:0004159	double aortic arch	defect in which the main aorta tube splits into large left and right branches (right and left aortic arches), encircling the trachea and esophagus, before becoming one tube to go to the lower body
MP:0004160	retroesophageal right subclavian artery	the subclavian artery aberrantly originates from the aortic arch distal to the origin of the left subclavian artery, i.e., it is the last branch of the aortic arch
MP:0004161	cervical aortic arch	aortic arch is located above the level of the clavicle
MP:0004162	abnormal mammillary body morphology	any structural anomaly of the protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei
MP:0004163	abnormal adenohypophysis morphology	any structural anomaly of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus
MP:0004164	abnormal neurohypophysis morphology	any structural anomaly of the posterior part of the pituitary gland that secretes hormones involved in blood pressure regulation such as oxytocin and antidiuretic hormone
MP:0004165	abnormal lateral geniculate nucleus morphology	any structural anomaly of the group of neurons that serve as the primary processor of visual information received from the retina via the optic tract and send processed information to the visual cortex of the occipital lobe
MP:0004166	abnormal limbic system morphology	any structural anomaly of any of a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory; these structures act together to control the endocrine system and the autonomic nervous system
MP:0004167	abnormal cingulate gyrus morphology	any structural anomaly of the ridge in the cerebral cortex located dorsal to the corpus callosum that controls autonomic functions regulating heart rate and blood pressure as well as cognitive and attentional processing
MP:0004168	abnormal parahippocampal gyrus morphology	any structural anomaly of the ridge in the cerebral cortex that contains the olfactory cortex and that plays a role in the formation of topographical memory
MP:0004169	abnormal fornicate gyrus morphology	any structural anomaly of the horseshoe-shaped gyrus of the cerebral cortex that consists of the cingulate gyrus and the parahippocampal gyrus
MP:0004170	abnormal orbitofrontal cortex morphology	any structural anomaly of the region of the cerebral cortex covering the basal surface of the frontal lobes; this region normally controls emotion and decision making
MP:0004171	abnormal pallium development	anomaly in the progression of the formation of the roof region of the telencephalon
MP:0004172	abnormal subpallium development	anomaly in the progression of the formation of the base region of the telencephalon
MP:0004173	abnormal intervertebral disk morphology	any structural anomaly of the cartilaginous and gelatinous structure found between vertebrae
MP:0004174	abnormal spine curvature	deviation from the typical S-shape of the spine
MP:0004175	telangiectasia	vascular lesion formed by dilation of a group of small blood vessels
MP:0004176	ear telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the ear
MP:0004177	tail telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the tail
MP:0004178	neck telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the neck
MP:0004179	transmission ratio distortion	the frequency that an allele or haplotype in the offspring of an organism deviates from expected Mendelian ratios
MP:0004180	failure of initiation of embryo turning	failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage
MP:0004181	abnormal carotid artery morphology	any structural anomaly of the bilaterally paired branched arteries that deliver oxygenated nutrient filled blood from the heart to the head, neck, and brain; of the two common carotid arteries, which extend headward on each side of the anterior neck, the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery near the top of the thyroid
MP:0004182	abnormal spermiation	anomaly in the process by which mature spermatids are released from the supporting Sertoli cells into the lumen of seminiferous tubules prior to their passage to the epididymis
MP:0004183	abnormal sympathetic nervous system physiology	any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body's response to stressful situations
MP:0004184	abnormal baroreceptor physiology	any functional anomaly of the sensory nerve endings found in the wall of the atria of the heart, vena cava, aortic arch and carotid sinus that are sensitive to changes in blood pressure
MP:0004185	abnormal adipocyte glucose uptake	anomaly in the ability of adipocytes to take in glucose
MP:0004186	abnormal area postrema morphology	any structural anomaly of the small, elevated area in the lateral wall of the inferior recess of the fourth ventricle, involved in the control of cardiorespiratory physiology; in addition, the area postrema is the location of the chemotoxic trigger zone at which emesis (vomiting) is induced by various toxins in the blood stream and that affect the hypothalamus to induce taste aversion
MP:0004187	cardia bifida	failure of the bilateral myocardial cells to coalesce into a single central heart tube resulting in the presence of two independent hearts
MP:0004188	delayed embryo turning	completion of axial rotation occurs later than in controls but is eventually completed
MP:0004189	abnormal alveolar process morphology	any structural anomaly of the thickened ridge of bone in the mandible and maxilla that holds the tooth sockets
MP:0004190	abnormal direction of embryo turning	axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage; clockwise rotation is frequently associated with heart and visceral defects
MP:0004191	neuronal intranuclear inclusions	presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington's disease
MP:0004192	abnormal kidney pyramid morphology	any structural anomaly of the conical mass of tissue, containing part of the secreting and collecting tubules, whose base faces the renal cortex
MP:0004193	abnormal kidney papilla morphology	any structural anomaly of the apex of the renal pyramid that projects into a calyx
MP:0004194	abnormal kidney pelvis morphology	any structural anomaly of the area at the center of the kidney formed by convergence of the major calices where urine collects and is funneled into the ureter
MP:0004195	abnormal kidney calyx morphology	any structural anomaly of any of the branches of the renal pelvis that surround each renal papilla and collect urine
MP:0004196	abnormal prenatal growth/weight/body size	limited or accelerated growth or development apparent before birth
MP:0004197	abnormal fetal growth/weight/body size	limited or accelerated growth or development apparent during the fetal period (sensu Mus: from E14 through birth)
MP:0004198	abnormal fetal size	anomalous proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)
MP:0004199	increased fetal size	larger proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)
MP:0004200	decreased fetal size	smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)
MP:0004201	fetal growth retardation	slow or limited development during the fetal period (sensu Mus: from E14 through birth)
MP:0004202	pulmonary hyperplasia	increase in the number of normal cells in normal arrangement in the lung, typically resulting in increased size
MP:0004203	abnormal cranial flexure morphology	any structural anomaly or absence of the sharp, ventrally concave bend in the developing midbrain of the embryo
MP:0004204	absent stapes	absence of the smallest and innermost of the three auditory ossicles
MP:0004205	absent hyoid bone	absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles
MP:0004206	abnormal dermomyotome development	any structural anomaly of the portion of the embryonic somite that remains after migration of the sclerotomic tissue
MP:0004207	increased squamous cell carcinoma incidence	higher than normal incidence of a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix
MP:0004208	increased basal cell carcinoma incidence	greater than the expected number of a slow-growing, invasive, but usually non-metastasizing neoplasm that originates from basal keratinocytes in the epidermis, occurring in a specific population in a given time period
MP:0004209	abnormal sweet taste sensitivity	changes in the ability to perceive a particular flavor or suggestion of something sweet by the chemoreceptors of the gustatory system
MP:0004210	abnormal bitter taste sensitivity	changes in the ability to perceive a particular flavor or suggestion of something bitter by the chemoreceptors of the gustatory system
MP:0004211	abnormal sour taste sensitivity	changes in the ability to perceive a particular flavor or suggestion of something sour by the chemoreceptors of the gustatory system
MP:0004212	abnormal salty taste sensitivity	changes in the ability to perceive a particular flavor or suggestion of something salty by the chemoreceptors of the gustatory system
MP:0004213	abnormal umami taste sensitivity	changes in the ability to perceive a particular flavor or suggestion of something umami (savory) by the chemoreceptors of the gustatory system
MP:0004214	abnormal long bone diaphysis morphology	any structural anomaly of the main or mid section (shaft) of a long bone
MP:0004215	abnormal myocardial fiber physiology	anomaly in the function of the terminally differentiated, non-proliferative, multinucleated muscle cells of the heart
MP:0004216	salt-resistant hypertension	sustained high blood pressure that is maintained regardless of the amount of salt consumed in the diet
MP:0004217	salt-sensitive hypertension	sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet
MP:0004218	meiotic nondisjunction during M1 phase	abnormal separation of pairs of homologous chromosomes during anaphase of the first meiotic division such that each daughter cell receives one set of paired chromosomes
MP:0004219	meiotic nondisjunction during M2 phase	abnormal separation of chromosomes during anaphase of the second meiotic division such that one complete chromosome goes to each daughter cell
MP:0004220	abnormal peripheral nervous system regeneration	anomaly in the renewal, repair, and/or regrowth of peripheral nervous system tissue following injury or disease
MP:0004221	abnormal iridocorneal angle	any structural anomaly of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye
MP:0004222	iris synechia	an adhesion (synechia) of the iris to the cornea or lens of the eye that may develop from glaucoma, cataracts, uveitis, or keratitis or as a complication of surgery or trauma to the eye; synechiae may prevent or impede flow of aqueous fluid between the anterior and posterior chambers of the eye, resulting in angle closure glaucoma
MP:0004223	hypoplastic trabecular meshwork	decrease in the number of normal cells in normal arrangement in the trabecular meshwork of the eye, typically resulting in decreased size
MP:0004224	absent trabecular meshwork	absence of the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates
MP:0004225	patent cardiac foramen ovale	incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall
MP:0004226	absent Schlemm's canal	absence of the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation
MP:0004227	increased cellular sensitivity to ionizing radiation	increased incidence of cell death following exposure to ionizing radiation
MP:0004228	decreased cellular sensitivity to ionizing radiation	decreased incidence of cell death following exposure to ionizing radiation
MP:0004229	abnormal embryonic erythropoiesis	anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans
MP:0004230	abnormal embryonic erythrocyte morphology	any structural anomaly of the embryonic blood cells that carry oxygen; embryonic erythrocytes arise from yolk sac blood islands and express different types of hemoglobins (beta-H1, gamma-1 and zeta) than adult erythrocytes, and can enucleate in circulation
MP:0004231	abnormal calcium ion homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment
MP:0004232	decreased muscle weight	less than average muscle weight
MP:0004233	abnormal muscle weight	any anomaly in the average muscle weight
MP:0004234	abnormal masticatory muscle morphology	any structural anomaly of any of the muscles responsible for the movement of the jaws during mastication, including the masseter, temporal, and medial and lateral pterygoid muscles
MP:0004235	abnormal masseter muscle morphology	any structural anomaly of the masticatory muscle of posterior cheek with origin from the inferior border and medial surface of the zygomatic arch, with insertion into the lateral surface of the ramus of the mandible, with nerve supply from the masseteric nerve, and whose action closes the jaw during chewing
MP:0004236	absent masseter muscle	absence of the masticatory muscle of posterior cheek
MP:0004237	abnormal pterygoid muscle morphology	any structural anomaly of the muscles descending from the sphenoid bone to the lower jaw including the internal, or medial, pterygoid muscle and external, or lateral, pterygoid muscle; the action of the former is closing the jaws and that of the latter is opening the jaws, protruding the mandible, and moving the mandible from side to side
MP:0004238	absent pterygoid muscle	absence of either the internal or external or of both pterygoid muscles
MP:0004239	abnormal temporalis muscle morphology	any structural anomaly of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible
MP:0004240	absent temporalis muscle	absence of the superior-most masticatory muscle whose action is closing the jaws; its posterior portion retracts the mandible
MP:0004241	acantholysis	separation of prickle cells of the spinous layer of the epidermis, resulting in atrophy of the prickle cell layer, as in conditions such as pemphigus vulgaris and Darier disease
MP:0004242	abnormal plasmacytoid dendritic cell morphology	any structural anomaly of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli; plasmacytoid dendritic cells are found in the thymic medulla and lymph node T cell areas and are responsible for immune tolerance
MP:0004243	abnormal motor nerve collateral sprouting	aberrant response of a motor neuron to form new neuritic processes (sprouts) that emerge from the nodes of Ranvier or terminal arborizations in response to nerve injury (such as denervation), application of nerve toxin, or muscle inactivity (usually due to disease)
MP:0004244	abnormal miscarriage rate	change in frequency of a natural or accidental termination of a pregnancy at a stage where the embryo or the fetus is incapable of surviving independently of the mother
MP:0004245	genital hemorrhage	bleeding into the genitals
MP:0004246	abnormal extensor digitorum longus morphology	any structural anomaly of the penniform muscle of the lateral front part of the leg responsible for extension of the toes and dorsiflexion of the ankle
MP:0004247	small pancreas	decrease of the size of the pancreas compared to controls
MP:0004248	abnormal epaxial muscle morphology	any structural anomaly of the muscles derived from the medial myotome; includes the intrinsic back muscles
MP:0004249	abnormal crista ampullaris morphology	any structural anomaly in the elevation found on the inner surface of the ampullae of each semicircular duct; filaments of the vestibular nerve pass through the crista to reach hair cells on its surface; the hair cells are capped by the cupula, a gelatinous protein-polysaccharide mass
MP:0004250	tau protein deposits	formation of self-assembled tangles of paired helical filaments and straight filaments due to hyperphosphorylation of the tau protein; often seen in neuronal tissues of individuals with neurodegenerative disorders
MP:0004251	failure of heart looping	failure of the primitive heart tube to loop asymmetrically during early development
MP:0004252	abnormal direction of heart looping	deviation from the characteristic rightward direction of looping of the primitive heart tube; frequently seen in heterotaxy syndromes
MP:0004253	bifid atrial appendage	a cardiac anomaly whereby the left or right atrial appendage is cleaved, forming two separate pouches connected by a thin strand of muscular tissue
MP:0004254	cerebral amyloid angiopathy	a pathological condition where there is a deposition of amyloid in the walls of the small cerebral vessels which supply the brain; this results in an increased risk of infarcts and/or intracerebral hemorrhage, possibly resulting in dementia
MP:0004255	abnormal spongiotrophoblast layer morphology	any structural anomaly of the middle layer of the placenta between the outermost giant cells and the innermost labyrinth layer; it has a structural role and also produces several layer-specific secreted factors
MP:0004256	abnormal maternal decidual layer morphology	any structural anomaly of the maternal uterine-derived portion of the placenta
MP:0004257	abnormal placenta weight	any change in the weight of the organ of metabolic interchange between fetus and mother
MP:0004258	abnormal placenta size	anomaly in the size or shape of the organ of metabolic interchange between fetus and mother
MP:0004259	small placenta	reduced size of the size or shape of the organ of metabolic interchange between fetus and mother
MP:0004260	enlarged placenta	increased size of the size or shape of the organ of metabolic interchange between fetus and mother
MP:0004261	abnormal embryonic neuroepithelium morphology	any structural anomaly of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells
MP:0004262	abnormal physical strength	altered ability of an organism to exert force on physical objects or of the body to support its load
MP:0004263	abnormal limb posture	atypical intentionally or habitually assumed position of the limbs compared to the normal carriage of the body
MP:0004264	abnormal extraembryonic tissue physiology	any functional anomaly of the membranes involved with embryonic protection and nutrition
MP:0004265	abnormal placental transport	anomaly in the conveyance of metabolic products and nutrients across the placenta
MP:0004266	pale placenta	placenta lacking normal reddish coloration, often refers to bloodless condition
MP:0004267	abnormal optic tract morphology	any structural anomaly of the paired bands of optic nerve fibers running from the optic chiasma mostly to the lateral geniculate body, with a smaller number of fibers terminating in the superior colliculus and the pretectal region
MP:0004268	abnormal optic stalk morphology	any structural anomaly of the narrow, proximal portion of the optic vesicle which connects the embryonic eye and forebrain
MP:0004269	abnormal optic cup morphology	any structural anomaly of double walled structure formed by expansion and invagination of the distal end of the optic vesicle that develops into the pigmented and neuronal layers of the retina, with the mouth of the optic cup developing into the pupil of the eye
MP:0004270	analgesia	inability to sense pain
MP:0004272	abnormal basement membrane morphology	anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis
MP:0004273	abnormal basal lamina morphology	any structural anomaly of the sheet of extracellular matrix characteristically situated under epithelial cells, around muscles, nerves, capillaries, and fat cells, and situated between these elements and the underlying or surrounding connective tissue
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	any structural anomaly of the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles
MP:0004275	abnormal postnatal subventricular zone morphology	any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells
MP:0004276	abnormal medial ganglionic eminence morphology	any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE
MP:0004277	abnormal lateral ganglionic eminence morphology	any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE
MP:0004278	abnormal caudal ganglionic eminence morphology	any structural anomaly of the caudally located, distinct elevation of a transient proliferating cell mass of the fetal subventricular zone, located adjacent to the lateral ventricle
MP:0004279	abnormal rostral migratory stream morphology	any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs
MP:0004280	abnormal oculomotor nucleus morphology	any structural anomaly of the group of motor neurons in the floor of the midbrain that gives rise to motor fibers of the oculomotor nerve
MP:0004281	abnormal hypoglossal nucleus morphology	any structural anomaly of the group of motor neurons throughout most of the length of the medulla oblongata that give rise to the motor fibers of the hypoglossal nerve
MP:0004282	retrognathia	abnormal posterior-shifted positioning of the upper or lower jaw relative to the facial skeleton and soft tissues; a type of malocclusion, that is, misalignment of the teeth caused by abnormal positioning of the jaws; the mandible is more frequently affected than the maxilla
MP:0004283	absent cornea endothelium	absence of the single layer of large flattened cells that cover the surface of the cornea
MP:0004284	abnormal Descemet membrane morphology	any structural anomaly in the transparent homogeneous acellular layer found between the substantia propria and the endothelial layer of the cornea, considered to be a highly developed basement membrane
MP:0004285	absent Descemet membrane	absence of the transparent homogeneous acellular layer normally found between the substantia propria and the endothelial layer of the cornea
MP:0004286	abnormal internal auditory canal morphology	any structural anomaly in the canal beginning at the opening of the internal acoustic meatus in the posterior cranial fossa, passing laterally through the petrous portion of the temporal bone to end at the fundus, where a thin plate of bone separates it from the vestibule; it gives passage to the facial and vestibulocochlear nerves together with the labyrinthine artery and veins
MP:0004287	abnormal spiral limbus morphology	any structural anomaly in the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea
MP:0004288	abnormal spiral ligament morphology	any structural anomaly in the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches
MP:0004289	abnormal bony labyrinth	any structural anomaly in the series of cavities (cochlea, vestibule, and semicircular canals) contained within the otic capsule of the petrous portion of the temporal bone; the bony labyrinth is filled with perilymph, in which the delicate, endolymph-filled membranous labyrinth is suspended
MP:0004290	abnormal stapes footplate morphology	any structural anomaly in the flat portion of the stapes that fits in the oval window
MP:0004292	abnormal spiral ligament fibrocyte morphology	any structural anomaly in the four types of fibrocytes (types I, II , III and IV) that constitute the spiral ligament
MP:0004293	abnormal type I spiral ligament fibrocytes	any structural anomaly of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis
MP:0004294	abnormal type II spiral ligament fibrocytes	any structural anomaly of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence
MP:0004295	abnormal type III spiral ligament fibrocytes	any structural anomaly of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule
MP:0004296	abnormal type IV spiral ligament fibrocytes	any structural anomaly of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest
MP:0004297	abnormal proprioceptive neuron morphology	any structural anomaly of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord
MP:0004298	vestibular ganglion degeneration	loss of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus
MP:0004299	absent vestibular ganglion	absence of the group of bipolar sensory nerve cell bodies concerned with equilibration that form a swelling on the vestibular part of the eighth cranial nerve in the fundus of the internal acoustic meatus
MP:0004300	abnormal organ of Corti supporting cell morphology	any structural anomaly in the highly differentiated epithelial cells with distinctive morphological features surrounding the hair cells in the organ of Corti; inner hair cells (IHCs) are normally surrounded by (inner and outer) phalangeal cells while OHCs are in contact with Deiters and pillar cells; Hensen cells are positioned further laterally in the organ of Corti
MP:0004301	absent organ of Corti supporting cells	absence of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti
MP:0004302	abnormal Deiters cell morphology	any structural anomaly in the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities
MP:0004303	abnormal Hensen cell morphology	any structural anomaly in the supporting cells that form the lateral border of the organ of Corti, immediately to the outer side of Deiters' cells
MP:0004304	absent spiral limbus	absence of the border of the spiral lamina, i.e. the thickened periosteum covering the upper plate of the bony spiral lamina of the cochlea
MP:0004305	abnormal Rosenthal canal morphology	any structural anomaly in the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea; it is divided incompletely into two compartments by a winding shelf of bone, the bony spiral lamina
MP:0004306	small Rosenthal canal	reduced size of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea
MP:0004307	absent Rosenthal canal	absence of the winding tube of the bony labyrinth that makes two and a half turns about the modiolus of the cochlea
MP:0004308	abnormal basilar membrane morphology	any structural anomaly in the membrane extending from the bony spiral membrane to the basilar crest of the cochlea; it forms the greater part of the floor of the cochlear duct separating the latter from the scala tympani, and it supports the organ of Corti
MP:0004309	absent otic vesicle	absence of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear
MP:0004310	small otic vesicle	reduced size of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear
MP:0004311	otic vesicle hypoplasia	decrease in the number of normal cells in normal arrangement in the otic vesicle, typically resulting in decreased size
MP:0004312	absent pillar cells	absence of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti
MP:0004313	absent vestibulocochlear ganglion	absence of the group of neuron cell bodies associated with the eighth cranial nerve during embryogenesis; splits in later development to form the cochlear and vestibular ganglia
MP:0004314	absent inner ear vestibule	absence of the cavity between the semicircular canals and the cochlea of the inner ear
MP:0004315	absent vestibular saccule	absence of the smaller of the two sacs in the vestibule
MP:0004316	enlarged vestibular saccule	enlarged size of the cavity between the semicircular canals and the cochlea of the inner ear
MP:0004317	small vestibular saccule	reduced size of the cavity between the semicircular canals and the cochlea of the inner ear
MP:0004318	absent incus	absence of the middle of the three auditory ossicles
MP:0004319	absent malleus	absence of the largest of the three auditory ossicles, which resembles a club or hammer
MP:0004320	split sternum	the appearance of an abnormal division in the long flat bone of the chest which articulates with clavicle and first seven rib pairs
MP:0004321	short sternum	reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs
MP:0004322	abnormal sternebra morphology	any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum
MP:0004323	sternum hypoplasia	decrease in the number of normal cells in normal arrangement in the sternum, typically resulting in decreased size
MP:0004324	vestibular hair cell degeneration	degeneration or loss of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve
MP:0004325	absent vestibular hair cells	absence of the sensory epithelial cells of the maculae and cristae of the membranous labyrinth of the inner ear which are normally in synaptic contact with the vestibular nerve
MP:0004326	abnormal vestibular hair cell number	abnormal number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear
MP:0004327	increased vestibular hair cell number	increased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve
MP:0004328	decreased vestibular hair cell number	decreased number of cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the internal ear which are normally in synaptic contact with the vestibular nerve
MP:0004329	vestibular saccular degeneration	degeneration or loss of the smaller of the two sacs in the vestibule
MP:0004330	abnormal vestibular saccular macula morphology	any structural anomaly of the oval neuroepithelial sensory receptor in the anterior wall of the saccule; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies
MP:0004331	vestibular saccular macula degeneration	degeneration or loss of the oval neuroepithelial sensory receptor in the anterior wall of the saccule
MP:0004332	utricular degeneration	degeneration or loss of the larger of the two sacs in the vestibule
MP:0004333	abnormal utricular macula morphology	any structural anomaly of the neuroepithelial sensory receptor in the inferolateral wall of the utricle; hair cells of the neuroepithelium support the statoconial membrane and have terminal arborizations of vestibular nerve fibers around their bodies; normally sensitive to linear acceleration in the longitudinal axis of the body and to gravitational influences
MP:0004334	utricular macular degeneration	degeneration or loss of the neuroepithelial sensory receptor in the inferolateral wall of the utricle
MP:0004335	enlarged utricle	increased size of the larger of the two sacs in the vestibule
MP:0004336	small utricle	reduced size of the larger of the two sacs in the vestibule
MP:0004337	clavicle hypoplasia	decrease in the number of normal cells in normal arrangement in the clavicle, typically resulting in decreased size
MP:0004338	small clavicle	reduced size of one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula
MP:0004339	absent clavicle	missing one or both of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula
MP:0004340	short scapula	reduced length of either or both of the large, flat bones of the back part of the shoulder
MP:0004341	absent scapula	missing either or both of the large, flat bones of the back part of the shoulder
MP:0004342	scapular bone foramen	presence of a hole in either or both of the large, flat bones of the back part of the shoulder
MP:0004343	small scapula	reduced size of either or both of the large, flat bones of the back part of the shoulder
MP:0004344	scapular bone hypoplasia	decrease in the number of normal cells in normal arrangement in the scapular bone, typically resulting in decreased size
MP:0004345	abnormal acromion morphology	any structural anomaly of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder
MP:0004346	absent acromion	lack of the lateral end of the spine of the scapula which projects as a broad flattened process and articulates with the clavicle, and forms the point of the shoulder
MP:0004347	abnormal scapular spine morphology	any structural anomaly of the triangular ridge on the dorsal aspect of the scapula which separates the supra- from the infraspinatous fossa and where the trapezius and deltoid muscles are attached
MP:0004348	long femur	increased length of the long bone of the thigh
MP:0004349	absent femur	missing the long bone of the thigh
MP:0004350	long humerus	increased length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below
MP:0004351	short humerus	reduced length of one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below
MP:0004352	absent humerus	missing one or both of the bones of the forelimb that articulates with the scapula above and the radius and ulna below
MP:0004353	abnormal deltoid tuberosity morphology	any structural anomaly of a rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches
MP:0004354	absent deltoid tuberosity	missing the rough elevation at the middle of the lateral side of the shaft of the humerus to which the deltoid muscle attaches
MP:0004355	short radius	reduced length of the short bone of the lateral forearm
MP:0004356	radius hypoplasia	decrease in the number of normal cells in normal arrangement in the radius, typically resulting in decreased size
MP:0004357	long tibia	increased length of the medial and larger of the two bones of the lower leg
MP:0004358	bowed tibia	increased curvature of the medial and larger of the two bones of the lower leg
MP:0004359	short ulna	reduced length of the medial and larger of the two bones of the forearm
MP:0004360	absent ulna	missing the medial and larger of the two bones of the forearm
MP:0004361	bowed ulna	increased curvature of the medial and larger of the two bones of the forearm
MP:0004362	cochlear hair cell degeneration	degeneration or loss of the sensory epithelial cells of the cochlea; these cells are in synaptic contact with the auditory nerve
MP:0004363	stria vascularis degeneration	degeneration or loss of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph
MP:0004364	thin stria vascularis	reduced thickness of the stratified, secretory epithelium which lines the upper part of the cochlear spiral ligament and maintains potassium ion homeostasis in the endolymph
MP:0004365	abnormal strial basal cell morphology	any structural anomaly in the polarized cells which are juxtaposed to fibrocytes in the underlying spiral ligament
MP:0004366	abnormal strial marginal cell morphology	any structural anomaly in the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph; marginal cells form extensive interdigitations with the basal and intermediate cells in the normal adult stria
MP:0004367	abnormal strial intermediate cell morphology	any structural anomaly in the melanocytes known to migrate from the neural crest during ontogeny to become located between the epithelial marginal cell layer and the mesodermal basal cell layer within the intrastrial space; the predominant cellular component of the electrogenic machinery that generates an endocochlear potential (80-100 mV)
MP:0004368	abnormal stria vascularis vasculature morphology	any structural anomaly of the blood vessels supplying the stria vascularis in the cochlea of the inner ear
MP:0004369	absent utricle	absence of the larger of the two sacs in the vestibule
MP:0004370	long ulna	increased length of the medial and larger of the two bones of the forearm
MP:0004371	bowed femur	increased curvature of the long bone of the thigh
MP:0004372	bowed fibula	increased curvature of the lateral and smaller bone of the lower limb
MP:0004373	bowed humerus	increased curvature of the bone of the forelimb that articulates with the scapula above and the radius and ulna below
MP:0004374	bowed radius	increased curvature of the short bone of the lateral forearm
MP:0004375	enlarged frontal bone	increased size of the bone forming the forehead and roof of the eye orbit
MP:0004376	absent frontal bone	absence of the bone forming the forehead and roof of the eye orbit
MP:0004377	small frontal bone	reduced size of the bone forming the forehead and roof of the eye orbit
MP:0004378	frontal bone foramen	presence of a hole in the bone forming the forehead and roof of the eye orbit
MP:0004379	wide frontal bone	increased width of the bone forming the forehead and roof of the eye orbit
MP:0004380	short frontal bone	reduced length of the bone forming the forehead and roof of the eye orbit
MP:0004381	abnormal hair follicle melanocyte morphology	any structural anomaly of the cells that produce pigment in the hair follicles
MP:0004382	abnormal hair follicle melanogenesis	failure of or anomaly in the biosynthetic pathway of melanin formation in hair follicles
MP:0004383	absent interparietal bone	absence of the bone of the cranium that lies above and anterior to the occipital bone in some mammals
MP:0004384	small interparietal bone	reduced size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals
MP:0004385	interparietal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the interparietal bone, typically resulting in decreased size
MP:0004386	enlarged interparietal bone	increased size of the bone of the cranium that lies above and anterior to the occipital bone in some mammals
MP:0004387	abnormal prechordal plate morphology	any structural anomaly of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue
MP:0004388	absent prechordal plate	absence of the horseshoe-shaped thickening of the endoderm at the cranial (rostral) end of the primitive streak formed by the involution of Spemann's organizer cells which, together with the notochord, induces the formation of the neural plate from the overlying ectodermal cells and contributes mesodermal type cells to the surrounding tissue
MP:0004389	abnormal respiratory bronchiole morphology	any structural anomaly of the smallest bronchioles, which connect the terminal bronchioles to alveolar ducts and have alveoli rising from their walls
MP:0004390	abnormal bronchoalveolar duct junction morphology	any structural anomaly of the branch point connecting the respiratory bronchioles to the alveolar ducts
MP:0004391	abnormal respiratory conducting tube morphology	any structural anomaly of the tubes of the respiratory system that allow passage of air from the trachea to the terminal bronchioles
MP:0004392	abnormal CD8-positive, alpha-beta T cell physiology	any functional anomaly of the subset of T lymphocytes that express the CD8 marker on the cell surface
MP:0004393	abnormal cochlear inner hair cell morphology	any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there is a single row of flask-shaped inner hair cells tightly surrounded by supporting interphalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a more or less linear (or shallow) U-shaped pattern extend from the cell's surface through the cuticular plate into the endolymphic space inferior to the tectorial membrane
MP:0004394	abnormal cochlear inner hair cell number	abnormal number of the flask-shaped inner hair sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve
MP:0004395	increased cochlear inner hair cell number	increased number (or more than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti
MP:0004396	decreased cochlear inner hair cell number	decreased number (or less than the expected single row) of the flask-shaped inner hair sensory cells of the organ of Corti
MP:0004397	absent cochlear inner hair cells	absence of the single row of flask-shaped inner hair sensory cells of the organ of Corti
MP:0004398	cochlear inner hair cell degeneration	degeneration or loss of the single row of flask-shaped inner hair sensory cells of the organ of Corti
MP:0004399	abnormal cochlear outer hair cell morphology	any structural anomaly in the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve; there are three rows of columnar outer hair cells largely surrounded by cortilymph and supporting phalangeal cells; the apical end of each cell is anchored to the cuticular plate and about 100 stereocilia arranged in a V-shaped pattern extend from the cell's surface through the cuticular plate into the tectorial membrane
MP:0004400	abnormal cochlear outer hair cell number	abnormal number of the columnar outer hair sensory cells of the organ of Corti
MP:0004401	increased cochlear outer hair cell number	increased number (or more than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti
MP:0004402	decreased cochlear outer hair cell number	decreased number (or less than the expected 3 rows) of the columnar outer hair sensory cells of the organ of Corti
MP:0004403	absent cochlear outer hair cells	absence of the columnar outer hair sensory cells of the organ of Corti
MP:0004404	cochlear outer hair cell degeneration	degeneration or loss of the columnar outer hair sensory cells of the organ of Corti
MP:0004405	absent cochlear hair cells	absence of the sensory epithelial cells of the cochlea; these cells are normally in synaptic contact with the auditory nerve
MP:0004406	abnormal cochlear hair cell number	abnormal number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve
MP:0004407	increased cochlear hair cell number	increased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve
MP:0004408	decreased cochlear hair cell number	decreased number of the sensory epithelial cells of the cochlea, which are normally in synaptic contact with the auditory nerve
MP:0004409	abnormal crista ampullaris neuroepithelium morphology	any structural anomaly in the specialized sensory hair cells of the ampullary crest of the ampulla of each semicircular duct
MP:0004410	absent endocochlear potential	absence of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea, indicating a primary defect in fluid homeostasis of the inner ear
MP:0004411	decreased endocochlear potential	reduction of the electrical potential difference between the endolymphatic and perilymphatic compartments of the cochlea
MP:0004412	abnormal cochlear microphonics	any anomaly in the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound; the cochlear microphonic (CM) is an electric response dominated by OHC receptor potentials from the basal turn of the cochlea and provides a measure of transducer function in OHCs; in an active ear, CM waveforms show post-stimulus ringing (i.e. a cochlear echo) whereas in a passive ear system, CM decays at the cessation of the tone burst
MP:0004413	absent cochlear microphonics	absence or loss of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound
MP:0004414	decreased cochlear microphonics	reduction of the bioelectric potentials produced by the hair cells of the organ of Corti in response to sound
MP:0004415	abnormal cochlear nerve compound action potential	anomaly in the combined potentials resulting from activation of the auditory division of the eighth cranial nerve; these potentials represent the summed activity of multiple cochlear afferent fibers discharging synchronously and thus assess the combined functional state of OHCs, IHCs, and their primary afferent innervation
MP:0004416	absent cochlear nerve compound action potential	absence of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve
MP:0004417	decreased cochlear nerve compound action potential	reduction of the combined potentials resulting from activation of the auditory division of the eighth cranial nerve
MP:0004418	small parietal bone	reduced size of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium
MP:0004419	absent parietal bone	absence of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium
MP:0004420	parietal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the parietal bone, typically resulting in decreased size
MP:0004421	enlarged parietal bone	increased size of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium
MP:0004422	small temporal bone	reduced size of the large, irregular bone located at the base and side of the skull
MP:0004423	abnormal temporal bone squamous part morphology	any structural anomaly of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault
MP:0004424	temporal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the temporal bone, typically resulting in decreased size
MP:0004425	abnormal otolith organ morphology	any structural anomaly in the utricle and saccule of the inner ear which possess otoliths and respond to linear acceleration and deceleration, including gravity
MP:0004426	abnormal cochlear labyrinth morphology	any structural anomaly in the portion of the membranous labyrinth concerned with the sense of hearing (vs. the vestibular labyrinth, which is concerned with the sense of equilibration) and innervated by the cochlear nerve; it is located within the cochlea of the bony labyrinth, and consists of the cochlear duct, which contains the spiral organ
MP:0004427	abnormal vestibular labyrinth morphology	any structural anomaly in the portion of the membranous labyrinth concerned with the sense of equilibration (vs. the cochlear labyrinth, which is concerned with the sense of hearing) and innervated by the vestibular nerve; it is located within the semicircular canals and vestibule of the bony labyrinth, and consists of the utricle, saccule, and the semicircular, utriculosaccular, and endolymphatic ducts
MP:0004428	abnormal type I vestibular cell	any structural anomaly in the flask-shaped sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear, which are normally enclosed in calyx endings of afferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae
MP:0004429	abnormal type II vestibular cells	any structural anomaly in the cylindrical sensory cells of the maculae and cristae of the vestibular labyrinth of the inner ear which are normally contacted by bouton endings of afferent and efferent neurons; afferent and efferent nerve fibers of the vestibular nerve synapse with them; from the apical end of each cell a bundle of stereocilia and a kinocilium extend into the otolithic membrane of the maculae or the cupula of the cristae
MP:0004430	abnormal Claudius cell morphology	any structural anomaly in the columnar cells located on the floor of the ductus cochlearis external to the spiral organ (also known as the organ of Corti)
MP:0004431	abnormal hair cell mechanoelectric transduction	anomalous conversion of mechanical energy into electric(al) energy by sensory cells, such as auditory and vestibular hair cells, required for auditory sensation
MP:0004432	abnormal cochlear hair cell physiology	any functional anomaly in processes pertinent to the integrated function of cochlear hair cells i.e. the sensory cells in the spiral organ which are in synaptic contact with sensory as well as efferent fibers of the cochlear (auditory) nerve
MP:0004433	abnormal cochlear inner hair cell physiology	any functional anomaly in processes pertinent to the function of cochlear IHCs which constitute the true sensory cell type sending impulses via the cochlear (auditory) nerve
MP:0004434	abnormal cochlear outer hair cell physiology	any functional anomaly in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)
MP:0004435	abnormal cochlear outer hair cell electromotility	anomalous motility of the cochlear OHCs in response to electrical stimulation; normally, the motile response (i.e. rapid change in length and stiffness of OHCs) is closely coupled to the changing transduction current and provides a region-specific amplification in the movement of the spiral organ that enhances transduction at the IHCs in that specific region of the cochlear spiral, increasing both sensitivity and specificity; electromotility is believed to arise through voltage-gated conformational changes in motor protein (prestin) or proteins located in the lateral wall of the OHC
MP:0004436	absent cochlear outer hair cell electromotility	absence or loss of motility of the cochlear OHCs in response to electrical stimulation
MP:0004437	decreased cochlear outer hair cell electromotility	reduced motility of the cochlear OHCs in response to electrical stimulation
MP:0004438	abnormal vestibular hair cell physiology	anomalies in processes pertinent to the integrated function of the sensory epithelium of the maculae and cristae in the membranous labyrinth of the inner ear
MP:0004439	absent Meckel's cartilage	absence of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments
MP:0004440	absent occipital bone	absence of the bone at the lower, posterior part of the skull
MP:0004441	small occipital bone	reduced size of the bone at the lower, posterior part of the skull
MP:0004442	occipital bone foramen	presence of a hole in the bone at the lower, posterior part of the skull
MP:0004443	absent supraoccipital bone	absence of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young
MP:0004444	small supraoccipital bone	reduced size of the bone on the dorsal side of the great foramen of the skull, usually forming a part of the occipital in the adult, but distinct in the young
MP:0004445	small exoccipital bone	reduced size of the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young
MP:0004446	split exoccipital bone	the appearance of an abnormal division in the bone or region on the lateral sides of the great foremen of the skull, which often forms a part of the occipital in the adult, but is usually distinct in the young
MP:0004447	small basioccipital bone	reduced size of the bone in the base of the cranium, frequently forming a part of the occipital in the adult, but usually distinct in the young
MP:0004448	abnormal presphenoid bone morphology	any structural anomaly of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult
MP:0004449	absent presphenoid bone	absence of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult
MP:0004450	presphenoid bone hypoplasia	decrease in the number of normal cells in normal arrangement in the presphenoid bone, typically resulting in decreased size
MP:0004451	short presphenoid bone	reduced length of the anterior part of the body of the sphenoid bone in front of the basisphenoid; it is usually a separate bone in the young or fetus, but becomes a part of the sphenoid in the adult
MP:0004452	abnormal pterygoid process morphology	any structural anomaly of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes
MP:0004453	abnormal pterygoid bone morphology	any structural anomaly of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull
MP:0004454	absent pterygoid process	absence of the process projecting downward from either side of the sphenoid bone, in vertebrates divided into two plates, an inner and an outer (sometimes called the lateral and medial); the posterior nares pass through the space, called the pterygoid fossa, between the processes
MP:0004455	pterygoid bone hypoplasia	decrease in the number of normal cells in normal arrangement in the pterygoid bone, typically resulting in decreased size
MP:0004456	small pterygoid bone	reduced size of the bone region which corresponds to the inner plate of the pterygoid process of the mammalian skull
MP:0004457	abnormal orbitosphenoid bone morphology	any structural anomaly of the bone that is situated in the orbit on either side of the presphenoid; it generally forms a part of the sphenoid in the adult, and may be independent in the young
MP:0004458	absent alisphenoid bone	absence of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young
MP:0004459	small alisphenoid bone	reduced size of either of the broad curved wing like expanses on each side of the sphenoid bone in adults; may exist independently in the young
MP:0004460	alisphenoid bone hypoplasia	decrease in the number of normal cells in normal arrangement in the alisphenoid bone, typically resulting in decreased size
MP:0004461	basisphenoid bone hypoplasia	decrease in the number of normal cells in normal arrangement in the basisphenoid bone, typically resulting in decreased size
MP:0004462	small basisphenoid bone	reduced size of part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone
MP:0004463	basisphenoid bone foramen	the presence of one or more holes in part of the base of the cranium between the basioccipital and the presphenoid, which usually ossifies separately in the embryo or in the young, and becomes a part of the sphenoid in the adult; in many animals it persists as a separate bone between the basioccipital bone and the presphenoidal bone
MP:0004464	absent strial basal cell tight junctions	absence of tight junctions from the basal cell layer of stria vascularis, resulting in destruction of the paracellular barrier between basal cells; loss of basal cell tight junctions renders the intrastrial space open to perilymph and abolishes its electrical isolation
MP:0004465	degeneration of organ of Corti supporting cells	degeneration or loss of the highly differentiated epithelial cells with distinctive morphological features that surround all hair cells in the organ of Corti
MP:0004466	short cochlear outer hair cells	reduced height of the sensory cells of the organ of Corti which are in synaptic contact with sensory as well as efferent fibers of the auditory nerve
MP:0004467	absent zygomatic bone	absence of the quadrilateral bone that forms the prominence of the cheek
MP:0004468	small zygomatic bone	reduced size of the quadrilateral bone that forms the prominence of the cheek
MP:0004469	abnormal zygomatic arch morphology	any structural anomaly of the bony arch in vertebrates that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone
MP:0004470	small nasal bone	reduced size of either of two rectangular bone plates forming the bridge of the nose
MP:0004471	short nasal bone	reduced length of either of two rectangular bone plates forming the bridge of the nose
MP:0004472	broad nasal bone	increased width of either of two rectangular bone plates forming the bridge of the nose
MP:0004473	absent nasal bone	absence of either of two rectangular bone plates forming the bridge of the nose
MP:0004474	enlarged nasal bone	increased size of either of two rectangular bone plates forming the bridge of the nose
MP:0004475	palatine bone hypoplasia	decrease in the number of normal cells in normal arrangement in the palatine bone, typically resulting in decreased size
MP:0004476	absent palatine bone	absence of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits
MP:0004477	turbinate hypoplasia	decrease in the number of normal cells in normal arrangement in the turbinate, typically resulting in decreased size
MP:0004478	increased testicular teratoma incidence	greater than the expected number of a usually benign tumor found in the testis that is the result of an anomaly of germ cell development, occurring in a specific population in a given time period; teratomas typically contains a diversity of tissues often representing all organ systems such as hair, teeth, bone, thyroid, or nerve tissue
MP:0004479	abnormal oval window morphology	any structural anomaly of the oval opening on the medial wall of the tympanic cavity leading into the vestibule, close to the foot of the stapes
MP:0004480	abnormal round window morphology	any structural anomaly of the opening on the medial wall of the middle ear leading into the cochlea, closed in life by the secondary tympanic membrane; it serves to regulate fluid pressure in the inner ear
MP:0004481	abnormal conjunctival epithelium morphology	any structural anomaly of the conjunctival layer of epithelial cells covering inner surface of the eyelid and the front of the eyeball except over the cornea
MP:0004482	abnormal interdental cell morphology	any structural anomaly of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane
MP:0004483	absent interdental cells	absence of the long, spindle-shaped cells arranged in parallel rows, oriented with their vertical axis perpendicular to the luminal surface of the spiral limbus; they secrete potassium ions into the endolymph and secrete the tectorial membrane
MP:0004484	abnormal response of heart to induced stress	change in the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding
MP:0004485	increased response of heart to induced stress	increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding
MP:0004486	decreased response of heart to induced stress	decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding
MP:0004487	type I spiral ligament fibrocyte degeneration	degeneration or loss of type I spiral ligament fibrocytes which occupy the region beneath the stria vascularis
MP:0004488	type II spiral ligament fibrocyte degeneration	degeneration or loss of type II spiral ligament fibrocytes found in the suprastrial zone and the central area of the spiral ligament beneath the spiral prominence
MP:0004489	type III spiral ligament fibrocyte degeneration	degeneration or loss of type III spiral ligament fibrocytes which form a cell layer attached to the otic capsule
MP:0004490	type IV spiral ligament fibrocyte degeneration	degeneration or loss of type IV spiral ligament fibrocytes found in the triangular space inferior to the basilar crest
MP:0004491	abnormal orientation of outer hair cell stereociliary bundles	misorientation or rotation of outer hair cell (OHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium
MP:0004492	abnormal orientation of inner hair cell stereociliary bundles	misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium
MP:0004493	dilated cochlea	the luminal space of the cochlea is increased in volume or area, usually with an increase in contained fluid
MP:0004494	abnormal synaptic glutamate release	aberrant secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors
MP:0004495	decreased synaptic glutamate release	reduced secretion across synapses of the major excitatory neurotransmitter of the central nervous system (CNS), which acts through both ligand gated ion channels (ionotropic receptors) and G protein-coupled (metabotropic) receptors
MP:0004496	abnormal organ of Corti supporting cell number	abnormal number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti
MP:0004497	decreased organ of Corti supporting cell number	decreased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti
MP:0004498	increased organ of Corti supporting cell number	increased number of the highly differentiated epithelial cells with distinctive morphological features which surround the hair cells in the organ of Corti
MP:0004499	increased incidence of tumors by chemical induction	higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens
MP:0004500	increased incidence of tumors by ionizing radiation induction	higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays
MP:0004501	increased incidence of tumors by UV-induction	higher than normal frequency of tumor incidence induced by exposure to ultraviolet light
MP:0004502	decreased incidence of tumors by chemical induction	lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens
MP:0004503	decreased incidence of tumors by ionizing radiation induction	lower than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays
MP:0004504	decreased incidence of tumors by UV induction	lower than normal frequency of tumor incidence induced by exposure to ultraviolet light
MP:0004505	decreased renal glomerulus number	reduced number of the capillary loops of the kidney that normally function as a filtration unit
MP:0004506	abnormal pubis morphology	any structural anomaly of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis
MP:0004507	abnormal ischium morphology	any structural anomaly of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis
MP:0004508	abnormal pectoral girdle bone morphology	any structural anomaly of the bones of the shoulder by which the limbs attach to the axial skeleton
MP:0004509	abnormal pelvic girdle bone morphology	any structural anomaly of the bones of the pelvis by which the limbs attach to the axial skeleton
MP:0004510	myositis	inflammation of muscle; local accumulation of fluid, plasma proteins, and leukocytes in muscle
MP:0004512	anosmia	loss of the sense of smell
MP:0004513	avnosmia	loss of the ability to detect pheromones through the vomeronasal system
MP:0004514	dystocia	slow or difficult delivery of offspring and/or placenta
MP:0004515	abnormal vestibular hair cell stereociliary bundle morphology	any structural anomaly or disruption of the typical staircase-like arrangement of the mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of vestibular hair cells of the utricle and saccule
MP:0004516	fused vestibular hair cell stereocilia	coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells, often resulting in giant stereocilia
MP:0004517	decreased vestibular hair cell stereocilia number	decreased number of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on vestibular hair cells in a staircase-like pattern
MP:0004518	absent vestibular hair cell stereocilia	complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern
MP:0004519	thin vestibular hair cell stereocilia	reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern
MP:0004520	short vestibular hair cell stereocilia	reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on vestibular hair cells in a staircase-like pattern
MP:0004521	abnormal cochlear hair cell stereociliary bundle morphology	any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells
MP:0004522	abnormal orientation of cochlear hair cell stereociliary bundles	misorientation or rotation of inner and/or outer hair cell stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium
MP:0004523	decreased cochlear hair cell stereocilia number	decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner and outer hair cells
MP:0004524	short cochlear hair cell stereocilia	reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells
MP:0004525	thin cochlear hair cell stereocilia	reduced thickness of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells
MP:0004526	absent cochlear hair cell stereocilia	complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells
MP:0004527	abnormal outer hair cell stereociliary bundle morphology	any structural anomaly or disruption of the typical V or W-like pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear OHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest (outermost) row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia
MP:0004528	fused outer hair cell stereocilia	coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells, often resulting in giant stereocilia
MP:0004529	decreased outer hair cell stereocilia number	decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear outer hair cells
MP:0004530	absent outer hair cell stereocilia	complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells
MP:0004531	short outer hair cell stereocilia	reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear outer hair cells
MP:0004532	abnormal inner hair cell stereociliary bundle morphology	any structural anomaly or disruption of the typically linear or U-shaped pattern of arrangement of mechanosensitive hair bundles located at the apical end of cochlear IHCs; each hair bundle is normally composed of ~100 nonmotile, actin-filled microvilli (stereocilia) arranged in rows of increasing height and coupled to one another by morphologically distinct links: tip links, horizontal top connectors, shaft connectors, and ankle links; most hair bundles also possess a single motile kinocilium immediately adjacent to the tallest row of stereocilia; a fifth link type, the kinocilial link, connects the kinocilium to its neighboring stereocilia
MP:0004533	fused inner hair cell stereocilia	coalescence of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells, often resulting in giant stereocilia
MP:0004534	decreased inner hair cell stereocilia number	decreased number (or less than the expected 100 or so) of the nonmotile, actin-filled specialized microvilli (stereocilia) normally arrayed on cochlear inner hair cells
MP:0004535	absent inner hair cell stereocilia	complete absence of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells
MP:0004536	short inner hair cell stereocilia	reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner hair cells
MP:0004537	abnormal palatine bone horizontal plate morphology	any structural anomaly of the bony plate of the palatine bone that normally fuses with maxillary shelf to form secondary (hard) palate
MP:0004538	abnormal maxillary shelf morphology	any structural anomaly of the bony projection of the maxilla that normally fuses with palatine shelf to form secondary (hard) palate
MP:0004539	absent maxilla	missing the upper bony framework of the mouth where the superior teeth are held
MP:0004540	small maxilla	reduced size of the upper bony framework of the mouth where the superior teeth are held
MP:0004541	absent auditory tube	absence of the tube connecting the tympanic cavity and the nasopharynx
MP:0004542	impaired acrosome reaction	reduced ability or inability to execute the cellular exocytosis of a single, anterior secretory granule following a sperm's attachment to the zona pellucida surrounding an oocyte
MP:0004543	abnormal sperm physiology	anomaly in the normal function of spermatozoa
MP:0004544	absent esophagus	absence of the part of the digestive canal through which food passes from the pharynx to the stomach
MP:0004545	enlarged esophagus	increased size of the part of the digestive canal through which food passes from the pharynx to the stomach
MP:0004546	esophagus hyperplasia	increase in the number of normal cells in normal arrangement in the esophagus, typically resulting in increased size
MP:0004547	esophageal ulcer	a lesion on the mucosal surface of the esophagus, usually produced by the sloughing of inflammatory necrotic tissue
MP:0004548	dilated esophagus	an expansion in the lumen volume of the part of the digestive canal through which food passes from the pharynx to the stomach
MP:0004549	small trachea	reduced size of the tube descending from the larynx and branching into the right and left main bronchi
MP:0004550	short trachea	reduced length of the tube descending from the larynx and branching into the right and left main bronchi
MP:0004551	decreased tracheal cartilage ring number	less than the expected number of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing
MP:0004552	fused tracheal cartilage rings	fusion of some or all of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing
MP:0004553	absent tracheal cartilage rings	absence of the incomplete C- or U-shaped rings of hyaline cartilage that support the trachea and prevent it from collapsing
MP:0004554	small pharynx	reduced size of the passage between the mouth and the posterior nares and the larynx and esophagus
MP:0004555	pharynx hypoplasia	decrease in the number of normal cells in normal arrangement in the pharynx, typically resulting in decreased size
MP:0004556	enlarged allantois	increased size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels
MP:0004557	dilated allantois	an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention
MP:0004558	delayed allantois development	late onset of development of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels
MP:0004559	small allantois	reduced size of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels
MP:0004560	abnormal chorionic plate morphology	any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta
MP:0004561	absent facial nerve	absence of the sensory and motor nerve that supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue
MP:0004562	abnormal inner hair cell synaptic ribbon morphology	any structural anomaly in the presynaptic active zone of mature cochlear IHCs which usually contain a single synaptic ribbon, i.e. a submicrometer, electron-dense structure tethering synaptic vesicles; each spiral ganglion neuron receives input from only one IHC synapse
MP:0004563	absent active-zone-anchored inner hair cell synaptic ribbon	absence or loss of the usually single synaptic ribbon, a characteristic osmiophilic, electron-dense structure to which synaptic vesicles are tethered at the active zone of the cochlear inner hair cell afferent synapse
MP:0004564	increased myocardial fiber size	increased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0004565	decreased myocardial fiber size	decreased size of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0004566	myocardial fiber degeneration	deterioration or destruction of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0004567	decreased myocardial fiber number	decreased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0004568	fusion of glossopharyngeal and vagus nerve	union of the ninth and tenth cranial nerves into a single structure
MP:0004569	glossopharyngeal nerve hypoplasia	decrease in the number of normal cells in normal arrangement in the glossopharyngeal nerve, typically resulting in decreased size
MP:0004570	absent glossopharyngeal nerve	absence of the sensory and autonomic axons to the parotid gland, carotid body, posterior third of the tongue; the branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion
MP:0004571	absent vagus nerve	absence of the autonomic, sensory and motor axons of the tenth cranial nerve; it is primarily sensory but also has visceromotor components; it originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components, and also controls some motor functions such as speech; the sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis
MP:0004572	fusion of basioccipital and basisphenoid bone	union of the basioccipital and basisphenoid bones into one structure, when this fusion does not normally occur (such as in a species where these bones normally persist as separate entities)
MP:0004573	absent limb buds	missing the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs
MP:0004574	broad limb buds	increased anterior-posterior width of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs
MP:0004575	small limb buds	reduced size of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs
MP:0004576	abnormal embryonic autopod plate morphology	any structural anomaly of transient  developing limb structure that forms by expansion of the distal end of the limb paddle and will give rise to the pedal appendages (e.g. hand, foot, paw)
MP:0004577	abnormal cochlear hair cell inter-stereocilial links morphology	any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of cochlear hair bundles; link types can be distinguished by their relative sensitivities to treatment with calcium chelators and the protease subtilisin; in the mature mouse cochlea, tip links and horizontal top connectors are the only inter-stereocilial links associated with the hair bundle; ankle links and transient lateral links are both prominent features of developing auditory hair bundles
MP:0004578	abnormal cochlear hair bundle tip links morphology	any structural anomaly in single, three-stranded interrow filaments that extend obliquely from the tip of one stereocilium to the lateral side of an adjacent taller stereocilium; in the mouse, tip links are already detectable prenatally and persist throughout life; tips links are thought to gate the mechanotransducer channel, are lost from the cell surface after exposure to either calcium chelator BAPTA or lanthanum, and resist degradation by the protease subtilisin
MP:0004579	abnormal cochlear hair bundle horizontal top connectors morphology	any structural anomaly in the inter-stereocilial links that connect the top of a shorter stereocilium to an adjacent longer stereocilium at a short distance below the tip links; the appearance of horizontal top connectors, which persist into adulthood, occurs concomitant with this loss of ankle links; top connectors are essentially unaffected by treatment with subtilisin and EGTA
MP:0004580	abnormal cochlear hair bundle transient lateral links morphology	any structural anomaly in the fine lateral links that interconnect stereocilia at prenatal stages; transient lateral links diminish at early postnatal stages when ankle links appear at the base of stereocilia, and are essentially unaffected by treatment with subtilisin and EGTA
MP:0004581	abnormal cochlear hair bundle ankle links morphology	any structural anomaly in the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down; in the mouse, ankle links are only a transient feature of the developing cochlear hair bundles, present predominantly from P2 though P9, but are absent by P12; ankle links are disrupted by treatment of hair cells with EGTA and subtilisin but not by La3+ and elastase
MP:0004582	absent cochlear hair bundle ankle links	absence of the long, single-stranded filaments that form a dense web or mesh around the base of cochlear hair bundles just above the region in which the stereocilia begin to taper down
MP:0004583	abnormal vestibular hair bundle inter-stereocilial links	any structural anomaly in the morphologically and biochemically distinct link types that extend between the stereocilia of vestibular hair bundles
MP:0004584	abnormal vestibular hair bundle shaft connectors	any structural anomaly in the links that connect the shafts of neighboring stereocilia in vestibular hair bundles; each shaft connector is composed of a ruthenium red-reactive, electron-dense particle that is connected to the plasma membrane by several fine strands of variable length
MP:0004585	absent vestibular hair bundle shaft connectors	absence of the inter-stereocilial links that connect the shafts of neighboring stereocilia in vestibular hair bundles
MP:0004586	pillar cell degeneration	degeneration or loss of the supporting cells that form the inner and outer walls of the tunnel in the organ of Corti
MP:0004587	decreased cellular sensitivity to X-ray irradiation	decreased incidence of cell death following exposure to X-ray irradiation
MP:0004588	abnormal vestibular hair cell development	atypical initial production, differentiation, migration or maturation of hair cells in the sensory epithelium of the maculae and cristae of the membranous labyrinth of the inner ear
MP:0004589	abnormal cochlear hair cell development	atypical initial production, differentiation, migration or maturation of the sensory epithelial cells of the cochlea
MP:0004590	absent Deiters cells	absence of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities
MP:0004591	enlarged tectorial membrane	increased size of the overlaying membrane of cochlear duct, an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells
MP:0004592	small mandible	reduced size of the lower bony framework of the mouth where the inferior teeth are held
MP:0004593	long mandible	increased length of the lower bony framework of the mouth where the inferior teeth are held
MP:0004594	abnormal mandibular coronoid process morphology	any structural anomaly of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion); includes the attachment site to the temporal muscle
MP:0004595	abnormal mandibular condyloid process morphology	any structural anomaly of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint
MP:0004596	abnormal mandibular angle morphology	any structural anomaly of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles
MP:0004597	increased susceptibility to noise-induced hearing loss	greater than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea
MP:0004598	abnormal cochlear basement membrane morphology	any structural anomaly in the continuous basement membrane found within the membranous labyrinth of the cochlea, known to extend from the limbus, down to the inner sulcus, across the basilar membrane, up to the external sulcus to the spiral prominence and radiating into the spiral ligament ensheathing the root cell processes
MP:0004599	abnormal vertebral arch morphology	any structural anomaly of the dorsal bony and/or cartilaginous part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)
MP:0004600	abnormal vertebral transverse process morphology	any structural anomaly of the bony protrusions on either side of the arch of a vertebrae at the point where the lamina joins the pedicle, between the superior and inferior articular processes; muscles and ligaments attach to these processes
MP:0004601	abnormal vertebral spinous process morphology	any structural anomaly of the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments
MP:0004602	abnormal vertebral articular process morphology	any structural anomaly of the bilateral flat projections that arise from the junctions of the pedicles and laminae
MP:0004603	absent vertebral arch	loss of the dorsal part of a vertebra, consisting of a pair of pedicles, a pair of laminae, and seven processes (four articular processes, two transverse processes, and one spinous process)
MP:0004604	abnormal vertebral pedicle morphology	any structural anomaly of the two short, thick processes, which project backward, one on either side, from the upper part of the body to the laminae
MP:0004605	abnormal vertebral lamina morphology	any structural anomaly of two broad plates directed dorsomedially from the pedicles; these fuse at the dorsal midline, and complete the dorsal wall of the vertebral foramen
MP:0004606	absent vertebral spinous process	missing the dorsal projection of the vertebral arch that projects backward and downward from the junction of the laminae, and serves for the attachment of muscles and ligaments
MP:0004607	abnormal cervical atlas morphology	any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head
MP:0004608	abnormal cervical axis morphology	any structural anomaly of the second cervical vertebra (C2) which forms the pivot upon which the first cervical (atlas, C1) vertebra rotates
MP:0004609	vertebral fusion	the union of one or more vertebrae into a single structure
MP:0004610	small vertebrae	reduced size of the bony segments of the spinal column
MP:0004611	increased susceptibility to ototoxicity-induced hearing loss	greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process
MP:0004612	fusion of vertebral bodies	improper union of the main cylindrical portion of adjacent vertebra ventral to the vertebral canal
MP:0004613	fusion of vertebral arches	improper union of the dorsal part of adjacent vertebra
MP:0004614	caudal vertebral transformation	homeotic transformation of any caudal vertebrae to adopt the fate of another vertebrae
MP:0004615	cervical vertebral transformation	homeotic transformation of any cervical vertebrae to adopt the fate of another vertebrae
MP:0004616	lumbar vertebral transformation	homeotic transformation of any lumbar vertebrae to adopt the fate of another vertebrae
MP:0004617	sacral vertebral transformation	homeotic transformation of any sacral vertebrae to adopt the fate of another vertebrae
MP:0004618	thoracic vertebral transformation	homeotic transformation of any thoracic vertebrae to adopt the fate of another vertebrae
MP:0004619	caudal vertebral fusion	the union of one or more caudal vertebrae into a single structure in species where this does not normally occur
MP:0004620	cervical vertebral fusion	the union of one or more cervical vertebrae into a single structure
MP:0004621	lumbar vertebral fusion	the union of one or more lumbar vertebrae into a single structure
MP:0004622	sacral vertebral fusion	the union of one or more sacral vertebrae into a single structure in species where this does not normally occur
MP:0004623	thoracic vertebral fusion	the union of one or more thoracic vertebrae into a single structure
MP:0004624	abnormal thoracic cage morphology	any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum
MP:0004625	abnormal rib joint morphology	any anomaly in the normal joining of the ribs to the vertebral column or to the sternum
MP:0004626	vertebral compression	appearance of vertebrae that are flattened laterally along the whole length such that they appear pressed together and take up less rostrocaudal space
MP:0004627	abnormal trochanter morphology	any structural anomaly of the bony prominences near the upper extremity of the femur; there are two in human (greater and lesser trochanters) and three in many other mammalian species (greater, lesser and third); these normally serve as attachment points for hip and thigh muscles
MP:0004628	Deiters cell degeneration	degeneration or loss of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities
MP:0004629	abnormal spiral modiolar artery morphology	any structural anomaly of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus, serving the ganglion and the cochlear duct and its contents
MP:0004630	spiral modiolar artery stenosis	abnormal narrowing or constriction of the artery which parallels the spiral ganglion in the root of the spiral lamina of the modiolus and serves the ganglion and the cochlear duct and its contents
MP:0004631	abnormal auditory cortex morphology	any structural anomaly in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body, a thalamic cell group receiving auditory input from the cochlear nuclei in the rhombencephalon and is responsible for processing of auditory (sound) information
MP:0004632	abnormal cochlear OHC efferent innervation pattern	any changes in the morphology or number of efferent terminals, occurring as clusters, in the cochlear OHC region; normally, medial olivocochlear neurons, which are primarily found in rostral and ventral periolivary regions, project mainly to the contralateral cochlea, and terminate directly on OHCs
MP:0004633	abnormal cochlear IHC efferent innervation pattern	any changes in the morphology of the normally dense plexus of efferent terminals that contact radial fibers of the spiral ganglion below cochlear IHCs or of the sparser plexus of terminals positioned around IHC somata; normally, lateral olivocochlear neurons, which are found in and/or around the lateral superior olive, project mainly to the ipsilateral cochlea and terminate mostly on dendritic fibers below IHCs
MP:0004634	short metacarpal bones	reduced length of the five bones of the forepaws that articulate proximally with the carpal bones and distally with the phalanges
MP:0004635	short metatarsal bones	reduced length of the five bones of the hindpaws that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges
MP:0004636	decreased metacarpal bone number	reduced number of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges
MP:0004637	metacarpal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the metacarpal bones, typically resulting in decreased size
MP:0004638	elongated metacarpal bones	increased length of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges
MP:0004639	fused metacarpal bones	improper union of one or more of the five bones of the forepaws/hands that articulate proximally with the carpal bones and distally with the phalanges
MP:0004640	decreased metatarsal bone number	reduced number of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges
MP:0004641	elongated metatarsal bones	increased length of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges
MP:0004642	fused metatarsal bones	improper union of the five bones of the hindpaws/feet that articulate proximally with the cuneiform and cuboid bones of the tarsus and distally with the phalanges
MP:0004643	abnormal vertebrae number	altered number of the bony segments of the spinal column
MP:0004644	increased vertebrae number	an increase over the normal number of the bony segments of the spinal column
MP:0004645	decreased vertebrae number	a reduction from the normal number of the bony segments of the spinal column
MP:0004646	decreased cervical vertebrae number	reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull
MP:0004647	decreased lumbar vertebrae number	reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0004648	decreased thoracic vertebrae number	reduced number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae
MP:0004649	decreased sacral vertebrae number	reduced number of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae
MP:0004650	increased lumbar vertebrae number	increased number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0004651	increased thoracic vertebrae number	increased number of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae
MP:0004652	small caudal vertebrae	reduced size of the bony segments of the coccyx or tail
MP:0004653	absent caudal vertebrae	absence of all of the bony segments of the coccyx or tail
MP:0004654	absent lumbar vertebrae	absence of all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0004655	absent thoracic vertebrae	absence of all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae
MP:0004656	absent sacral vertebrae	absence of all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae
MP:0004657	small sacral vertebrae	reduced size of any or all of the bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae
MP:0004658	abnormal ventral tubercle of atlas morphology	any structural anomaly of the conical ventral projection on the arch of the atlas
MP:0004659	abnormal odontoid process morphology	any structural anomaly of the large protuberance that projects upward from the cervical axis, around which the cervical atlas rotates
MP:0004660	absent thyroid follicular cells	absence of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor
MP:0004661	absent thyroid parafollicular C-cells	absence of the neuroepithelial secretory cells that occur singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid; these cells secrete calcitonin, 5-hydroxytryptamine and dopamine
MP:0004662	abnormal thyroid diverticulum morphology	any structural anomaly in the endodermal bud derived from the endodermal epithelium of the embryonic pharyngeal floor
MP:0004663	athyroidism	congenital absence of the thyroid gland or suppression or absence of its hormonal secretion
MP:0004664	delayed inner ear development	slowed progression to structurally mature components of the labyrinth, including the semicircular canals, vestibule and cochlea
MP:0004665	abnormal stapedial artery morphology	any structural anomaly in the small artery that passes through the ring of the stapes; while the stapedial artery is a temporary artery thought to disappear at late embryonic stage in humans, the mouse stapedial artery is complete by E13 and persists into adulthood
MP:0004666	absent stapedial artery	absence of the small artery that passes through the ring of the stapes
MP:0004667	vertebral body hypoplasia	decrease in the number of normal cells in normal arrangement in the vertebral body, typically resulting in decreased size
MP:0004668	absent vertebral body	absence of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0004669	enlarged vertebral body	increased size of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0004670	small vertebral body	decreased size of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0004671	long ribs	increased length of the bones forming the bony wall of the chest
MP:0004672	short ribs	reduced length of the bones forming the bony wall of the chest
MP:0004673	splayed ribs	any deviation from the normal curvature of the ribs such that the ribs are turned outward
MP:0004674	thin ribs	a more slender appearance of the bones forming the bony wall of the chest
MP:0004675	rib fractures	a crack or break in the bones forming the bony wall of the chest
MP:0004676	wide ribs	an increase in the width of the bones forming the bony wall of the chest
MP:0004677	truncated ribs	ribs that terminate abruptly as if having an end or point cut off
MP:0004678	split xiphoid process	the appearance of an abnormal division of the caudal tip of the sternum
MP:0004679	xiphoid process foramen	the appearance of a hole or holes in the caudal tip of the sternum
MP:0004680	small xiphoid process	reduced size of the caudal tip of the sternum
MP:0004681	intervertebral disk hypoplasia	decrease in the number of normal cells in normal arrangement in the intervertebral disk, typically resulting in decreased size
MP:0004682	small intervertebral disk	reduced size of the cartilaginous and gelatinous structure found between vertebrae
MP:0004683	absent intervertebral disk	absence of the cartilaginous and gelatinous structure found between vertebrae
MP:0004684	intervertebral disk degeneration	retrogressive pathological change of the cartilaginous and gelatinous structure found between vertebrae
MP:0004685	calcified intervertebral disk	pathologic deposition of calcium salts in one or more intervertebral disks
MP:0004686	decreased length of long bones	reduced end-to-end length of the several elongated bones of the extremities
MP:0004687	split vertebrae	any vertebrae or vertebral section that is cleft into two parts
MP:0004688	absent ilium	absence of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis
MP:0004689	small ischium	reduced size of the lowest of the three major bones that constitute each half of the pelvis, distinct at birth but later becoming fused with the ilium and pubis
MP:0004690	ischium hypoplasia	decrease in the number of normal cells in normal arrangement in the ischium, typically resulting in decreased size
MP:0004691	absent pubis	absence of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis
MP:0004692	small pubis	reduced size of the forward portion of either of the hipbones, at the juncture forming the front arch of the pelvis
MP:0004693	pubis hypoplasia	decrease in the number of normal cells in normal arrangement in the pubis, typically resulting in decreased size
MP:0004694	absent patella	absence of the large sesamoid bone that covers the anterior surface of the knee
MP:0004695	increased length of long bones	greater end-to-end length of the several elongated bones of the extremities
MP:0004696	abnormal thyroid follicle morphology	any structural anomaly of the small spherical vesicular components of the thyroid gland that are lined with epithelium and contain a colloid substance that both serves as a reservoir of materials for thyroid hormone production and stores thyroid hormones
MP:0004697	abnormal thyroid follicular cell morphology	any structural anomaly of the thyroxine-producing follicular cells derived from the thyroid diverticulum which evaginates from the endodermal epithelium of the embryonic pharyngeal floor
MP:0004698	abnormal thyroid parafollicular C-cell morphology	any structural anomaly of the neuroepithelial secretory cells that occur singly or in small groups, close to the outer follicular borders but within the follicular basement membrane of the thyroid; these cells secrete calcitonin, 5-hydroxytryptamine and dopamine
MP:0004699	unilateral deafness	bilateral asymmetry in auditory function whereby one of the two ears displays auditory thresholds indicative of intact hearing while the other ear displays thresholds reflecting auditory dysfunction
MP:0004700	abnormal circulating insulin-like growth factor I level	anomalous blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities
MP:0004701	decreased circulating insulin-like growth factor I level	reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities
MP:0004702	increased circulating insulin-like growth factor I level	increased blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities
MP:0004703	abnormal vertebral column morphology	any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord
MP:0004704	short vertebral column	decreased rostral-caudal length of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord
MP:0004705	elongated vertebral body	increased length of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0004706	short vertebral body	reduced length of the main cylindrical portion of the vertebra ventral to the vertebral canal
MP:0004707	enlarged lumbar vertebrae	increased size of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0004708	short lumbar vertebrae	reduced length of any or all of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae
MP:0004709	cervical vertebrae degeneration	retrogressive pathologic change of any or all of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull
MP:0004710	small notochord	reduced size of the axial fibrocellular cord in embryos around which develops the vertebral primordia
MP:0004711	persistence of notochord tissue	failure of notochord tissue to differentiate into the vertebral primordia during development resulting in the presence of notochord tissue at later stages than it is normally seen
MP:0004712	notochord degeneration	retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)
MP:0004713	split notochord	the appearance of an abnormal division in the axial fibrocellular cord in embryos around which develops the vertebral primordia
MP:0004714	truncated notochord	notochord morphology that terminates abruptly as if having an end or point cut off
MP:0004715	absent vestibulocochlear nerve	absence of the composite sensory nerve innervating the receptor cells of the membranous labyrinth
MP:0004716	abnormal cochlear nerve morphology	any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the cochlear root; composed of the central nerve processes of the bipolar neurons of the spiral ganglion, which have their peripheral processes on the four rows of neuroepithelial cells (hair cells) of the spiral organ
MP:0004717	absent cochlear nerve	absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the cochlear root
MP:0004718	abnormal vestibular nerve morphology	any structural anomaly in the part of the vestibulocochlear nerve [CN VIII] peripheral to the vestibular root; it is composed of the central processes of bipolar neurons that have the terminals of their peripheral processes on the hair cells in the ampullae of the semicircular ducts and the maculae of the saccule and utricle, and cell bodies of the vestibular ganglion
MP:0004719	absent vestibular nerve	absence of the part of the vestibulocochlear nerve [CN VIII] that is peripheral to the vestibular root
MP:0004720	abnormal platelet morphology	any structural anomaly of blood plasma cells derived from megakaryocytes, which function to promote blood clotting
MP:0004721	abnormal platelet dense granule morphology	any structural anomaly of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin
MP:0004722	abnormal platelet dense granule number	altered number of the electron-dense bodies occurring in blood platelets that store and secrete adenosine nucleotides and serotonin
MP:0004723	abnormal platelet serotonin level	anomaly in the amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
MP:0004724	increased platelet serotonin level	greater than normal amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
MP:0004725	decreased platelet serotonin level	reduced amount in platelets of serotonin, a biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
MP:0004726	abnormal nasal capsule morphology	any structural anomaly in the cartilage around the developing nasal cavity of the embryo
MP:0004727	absent epididymis	absence of the elongated structure connected to the posterior surface of the testis, consisting of the head, body, and tail, which turns sharply on itself to become the ductus deferens (vas deferens)
MP:0004728	abnormal efferent ductules of testis morphology	any structural anomaly in the small seminal ducts that lead from the testis to the head of the epididymis
MP:0004729	absent efferent ductules of testis	absence of the small seminal ducts that lead from the testis to the head of the epididymis
MP:0004730	abnormal circulating gastrin level	anomalous concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters
MP:0004731	increased circulating gastrin level	greater concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters
MP:0004732	decreased circulating gastrin level	reduced concentration in the blood of polypeptide hormones secreted by the pyloric-antral mucous lining of the stomach that induces the secretion of gastric juice by the parietal cells of the gastric glands; they also occur in the central nervous system where they are presumed to be neurotransmitters
MP:0004733	abnormal thoracic cavity morphology	any structural anomaly of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway
MP:0004734	small thoracic cavity	reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway
MP:0004735	enlarged thoracic cavity	increased size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway
MP:0004736	abnormal distortion product otoacoustic emission	any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs
MP:0004737	absent distortion product otoacoustic emissions	failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion
MP:0004738	abnormal auditory brainstem response	anomaly in the electrical activity generated in the ascending auditory system in response to short tone bursts; may be used to evaluate sensorineural hearing function; measurements may include the amplitude (the number of neurons firing), latency (the speed of transmission), interpeak latency (the time between peaks), interaural latency (the difference in wave V latency between ears) and threshold
MP:0004739	conductive hearing loss	progressive hearing loss due to lesions in the external auditory canal or middle ear
MP:0004740	sensorineural hearing loss	a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear
MP:0004741	mixed hearing loss	progressive reduction in the ability to hear resulting from a combination of conductive and sensorineural hearing loss
MP:0004742	abnormal vestibular system physiology	any functional anomaly of the sensory system responsible for the sense of head position and movement of the body through space; such anomalies may result in impaired balance, dizziness, poor regulation of postural muscle tone and inability to detect quick movements of the head
MP:0004743	abnormal vestibular evoked myogenic potential	anomaly in the biphasic response elicited by loud clicks or tone bursts recorded from the tonically contracted sternocleidomastoid muscle; normally, acoustic stimulation of the saccule gives rise to a vestibulocollic reflex, the output of which can be measured in the neck as inhibition of activity in the ipsilateral sternocleidomastoid muscle; VEMP testing provides diagnostic information about saccular and/or inferior vestibular nerve function (assessment of balance disorders)
MP:0004744	reduced vestibular evoked myogenic potential	reduction of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle
MP:0004745	absent vestibular evoked myogenic potential	absence of the biphasic response that is elicited by loud clicks or tone bursts and recorded from the tonically contracted sternocleidomastoid muscle
MP:0004746	abnormal cochlear IHC afferent innervation pattern	any changes in the placement, morphology or number of afferent terminals and/or their synapses in the cochlear IHC region
MP:0004747	abnormal cochlear OHC afferent innervation pattern	any changes in the morphology, placement or number of afferent terminals and/or their synapses in the cochlear OHC region
MP:0004748	increased susceptibility to age-related hearing loss	greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary
MP:0004749	nonsyndromic hearing loss	a form of progressive hearing loss that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear
MP:0004750	syndromic hearing loss	a form of progressive hearing loss that is usually associated with malformations of the external ear and other inherited signs and symptoms
MP:0004751	increased length of allograft survival	compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive
MP:0004752	decreased length of allograft survival	compared to controls, a reduced length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive
MP:0004753	abnormal miniature excitatory postsynaptic currents	defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse
MP:0004754	abnormal kidney collecting duct morphology	any structural anomaly of the kidney ducts lined by simple cuboidal epithelium that collect urine from the distal convoluted tubules, merge and become larger as they descend from the renal cortex into the medulla, and respond to vasopressin and aldosterone to regulate water, electrolyte and acid-base balance; each cortical collecting duct joints with other ducts to make a medullary connecting duct, which eventually drains into a papillary duct, emptying urine into the renal pelvis for drainage into the ureter
MP:0004755	abnormal loop of Henle morphology	any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine
MP:0004756	abnormal proximal convoluted tubule morphology	any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomerular capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes; the most distinctive characteristic of the proximal tubule is its brush border (or striated border), not found in the distal convoluted tubule
MP:0004757	abnormal distal convoluted tubule morphology	any structural anomaly of the convoluted portion of the duct system of the nephron between the ascending portion of the loop of Henle and the collecting duct system in the kidney cortex; it is partly responsible for the regulation of potassium, sodium, calcium, and pH through the endocrine system
MP:0004758	absent strial marginal cells	absence or loss of the polarized columnar cells of epithelial origin which cover the lateral surface of the cochlear duct, secrete potassium ions and form a continuous sheet in contact with the endolymph
MP:0004759	decreased mitotic index	decreased number of cells in G2/M phase
MP:0004760	increased mitotic index	increased number of cells in G2/M phase
MP:0004761	increased susceptibility to induced pancreatitis	more likely than normal to develop an inflammatory response, or an increased inflammatory response in the pancreatic tissue after experimental manipulation
MP:0004762	increased anti-double stranded DNA antibody level	increase in the level of antibodies that recognize double stranded DNA
MP:0004763	obsolete absent brainstem auditory evoked potential	absence of the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude
MP:0004764	obsolete increased brainstem auditory evoked potential	greater synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; decreases in auditory thresholds required to generate a response may indicate a increased potential
MP:0004765	obsolete decreased brainstem auditory evoked potential	reduction in the synchronous electrical activity generated by neurons in the ascending auditory system that can be recorded from scalp electrograms by using computer-averaged responses to short tone bursts; by varying frequency, cochlear function can be assessed throughout the hearing range; normally, ABR thresholds vary with frequency, from a sound pressure level (SPL) of 35 dB at 5.6 kHz (a relatively low frequency for a mouse) to 15 dB at 45.2 kHz (a relatively high frequency); each 20 dB corresponds to a tenfold change in amplitude; increases in auditory thresholds required to generate a response may indicate a decreased potential
MP:0004766	decreased susceptibility to age-related hearing loss	less than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary
MP:0004767	increased cochlear nerve compound action potential	greater combined potentials resulting from activation of the auditory division of the eighth cranial nerve
MP:0004768	abnormal axonal transport	any functional anomaly of the directed movement of organelles or vesicles along microtubules in nerve cell axons
MP:0004769	abnormal synaptic vesicle morphology	any structural anomaly of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents
MP:0004770	abnormal synaptic vesicle recycling	any functional anomaly in the process of the fusion of a subpopulation of synaptic vesicles with the cell membrane at the active zone, the subsequent endocytosis back from the plasma membrane, the refilling of these vesicles with neurotransmitters, and trafficking back to the active zone pool of vesicles
MP:0004771	increased anti-single stranded DNA antibody level	increase in the level of antibodies that recognize single stranded DNA
MP:0004772	abnormal bile secretion	any anomaly in the quantity or rate of bile secreted through the bile ducts in a given length of time
MP:0004773	abnormal bile composition	any alteration in the chemical make up of the greenish-yellow fluid secreted by the liver; normally contains bile acids and salts such as sodium glycocholate and sodium taurocholate as well as cholesterol, biliverdin and bilirubin, mucus, fat, lecithin, and cells and cellular debris
MP:0004774	abnormal bile salt level	anomalous concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats
MP:0004775	abnormal vestibular dark cell morphology	any structural anomaly in the nonsensory epithelial cells located above the vestibular melanocytes and adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals; these cells provide and maintain the high potassium ionic environment within the vestibular labyrinth and are therefore homologous to the marginal cells of the stria vascularis; they are joined to each other by tight junctions and provide a barrier between endolymph and perilymph
MP:0004776	vestibular dark cell degeneration	degeneration or loss of the nonsensory epithelial cells that lie adjacent to the sensory structures in the utricle and in the ampullae at the ends of each of the semicircular canals
MP:0004777	abnormal phospholipid level	anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group
MP:0004778	increased macrophage derived foam cell number	greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions
MP:0004780	abnormal surfactant secretion	anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli
MP:0004781	abnormal surfactant composition	anomaly in the chemical constituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli
MP:0004782	abnormal surfactant physiology	anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli
MP:0004783	abnormal cardinal vein morphology	any structural anomaly of any of the four veins in the developing vertebrate embryo which run along each side of the vertebral column
MP:0004784	abnormal anterior cardinal vein morphology	any structural anomaly of the two paired veins draining the cephalic part of the body
MP:0004785	abnormal posterior cardinal vein morphology	any structural anomaly of the two paired veins draining the caudal part of the body
MP:0004786	abnormal common cardinal vein morphology	any structural anomaly of the anastomosis of the anterior and posterior cardinal veins that returns blood to the developing heart
MP:0004787	abnormal dorsal aorta morphology	any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation
MP:0004788	abnormal auditory cortex tonotopy	any abnormality in the spatial arrangement of structures that subserve various frequencies in the region of the cerebral cortex that receives the auditory radiation from the medial geniculate body
MP:0004789	increased bile salt level	increased concentration of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats
MP:0004790	absent upper incisors	absence of the upper pair of long teeth that are the most anterior and prominent in the jaw
MP:0004791	absent lower incisors	missing the lower pair of long teeth that are the most anterior and prominent in the jaw
MP:0004792	abnormal synaptic vesicle number	anomaly in the number of the small, membrane bound sacs that contain various neurotransmitter molecules that are concentrated at pre-synaptic membranes and release the neurotransmitters by fusion of these vesicles with the presynaptic membrane, followed by exocytosis of their contents
MP:0004793	abnormal synaptic vesicle clustering	any functional anomaly in the process of accumulation of synaptic vesicles at the active zone of presynaptic membranes
MP:0004794	increased anti-nuclear antigen antibody level	elevated level of antibodies to nuclear antigens present in the sera
MP:0004795	decreased anti-nuclear antigen antibody level	reduced level of antibodies to nuclear antigens present in the sera
MP:0004796	increased anti-histone antibody level	elevated level of antibodies to histones present in the sera
MP:0004797	increased anti-erythrocyte antigen antibody level	elevated level of antibodies to erythrocyte antigen present in the sera
MP:0004798	decreased anti-double stranded DNA antibody level	reduced level of antibodies to double stranded DNA present in the sera
MP:0004799	increased susceptibility to experimental autoimmune encephalomyelitis	greater likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)
MP:0004800	decreased susceptibility to experimental autoimmune encephalomyelitis	reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)
MP:0004801	increased susceptibility to systemic lupus erythematosus	greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs
MP:0004802	decreased susceptibility to systemic lupus erythematosus	reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs
MP:0004803	increased susceptibility to autoimmune diabetes	greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas
MP:0004804	decreased susceptibility to autoimmune diabetes	reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas
MP:0004805	absent oocytes	absence of mature germ cells in the female
MP:0004806	absent germ cells	absence of germ cells, that is, any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated
MP:0004807	abnormal paired-pulse inhibition	any anomaly in the suppressive response of central synapses when activated twice in rapid succession
MP:0004808	abnormal hematopoietic stem cell morphology	any structural anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages
MP:0004809	increased hematopoietic stem cell number	greater cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages
MP:0004810	decreased hematopoietic stem cell number	reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow, yolk sac and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages
MP:0004811	abnormal neuron physiology	any functional anomaly of the cells of the nervous system that receive, conduct, and transmit impulses
MP:0004812	abnormal linear vestibular evoked potential	anomaly in the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head); normally, this response is measured by electrophysiological activity of the peripheral vestibular nerve; this assesses the function of the gravity receptor system including the utricles and saccules of the inner ear
MP:0004813	absent linear vestibular evoked potential	absence of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head)
MP:0004814	reduced linear vestibular evoked potential	reduction of the biphasic response elicited by linear acceleration transients (usually jerk pulses to an animal's head)
MP:0004815	abnormal somatic hypermutation frequency	any anomaly in the high frequency of programmed mutation that occurs in the gene segments encoding the variable regions of antibodies during the differentiation of individual B lymphocytes into antibody producing plasma cells
MP:0004816	abnormal class switch recombination	anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions
MP:0004817	abnormal skeletal muscle mass	anomaly in the physical bulk, or total amount of matter contained within skeletal muscle
MP:0004818	increased skeletal muscle mass	increase in the physical bulk, or total amount of matter contained within skeletal muscle
MP:0004819	decreased skeletal muscle mass	reduction in the physical bulk, or total amount of matter contained within skeletal muscle
MP:0004820	abnormal urine potassium level	any change in the amount of potassium in the urine
MP:0004821	increased susceptibility to experimental autoimmune uveoretinitis	greater likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens
MP:0004822	decreased susceptibility to experimental autoimmune uveoretinitis	reduced likelihood that an organism will develop disease symptoms similar to human sight-threatening inflammatory eye diseases upon induction by peripheral immunization with one of several uveitogenic retinal proteins (or with peptides derived from them), or by the adoptive transfer of lymphocytes specific to these antigens
MP:0004823	increased susceptibility to experimental autoimmune myasthenia gravis	greater likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits
MP:0004824	decreased susceptibility to experimental autoimmune myasthenia gravis	reduced likelihood that an organism will develop disease symptoms similar to human myasthenia gravis upon induction with antigens to acetylcholine receptor subunits
MP:0004825	increased susceptibility to experimental autoimmune thyroiditis	greater likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin
MP:0004826	decreased susceptibility to experimental autoimmune thyroiditis	reduced likelihood that an organism will develop disease symptoms similar to human autoimmune thyroiditis upon induction with antigens to thyroglobulin
MP:0004827	increased susceptibility to autoimmune hemolytic anemia	greater likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely
MP:0004828	decreased susceptibility to autoimmune hemolytic anemia	reduced likelihood that an organism will develop an abnormality of the immune system that destroys red blood cells (hemolysis) prematurely
MP:0004829	increased anti-chromatin antibody level	increase in the level of antibodies that recognize chromatin
MP:0004830	short incisors	reduced length of the set of long teeth that are the most anterior and prominent in the jaw
MP:0004831	long incisors	increased length of the set of long teeth that are the most anterior and prominent in the jaw
MP:0004832	enlarged ovary	increased size of the female reproductive gland containing the germ cells
MP:0004833	ovary atrophy	acquired diminution of the size of the ovaries associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0004834	ovary hemorrhage	presence of bleeding in the ovary
MP:0004835	abnormal miniature endplate potential	defect in the size or duration of spontaneous currents detected in PNS postsynaptic cells that occur in the absence of an excitatory impulse
MP:0004836	abnormal synaptic acetylcholine release	aberrant release into synapses of the excitatory neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system
MP:0004837	abnormal neural fold formation	any anomaly in the process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove
MP:0004838	abnormal neural fold elevation formation	any anomaly in the process by which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm
MP:0004839	bile duct hyperplasia	increase in the number of normal cells in normal arrangement in the bile ducts, typically resulting in increased size
MP:0004840	increased Deiters cell number	increased number of the supporting cells of the spiral organ which are attached to the basement membrane and receive the hair cells between their free extremities
MP:0004841	abnormal small intestine crypts of Lieberkuhn morphology	any structural anomaly of the parallel, tubular, epithelial pits (crypts) with openings at the bases of the small intestinal villi; their thin walls are formed by columnar epithelial cells: mostly undifferentiated stem and intermediate cells and an increasing number of mucus-secreting goblet cells as the small intestine proceeds distally, all of which migrate out of the glands onto the villi, but also protein- (enzyme-) secreting Paneth cells that remain in the glands
MP:0004842	abnormal large intestine crypts of Lieberkuhn morphology	any structural anomaly of the tubular intestinal glands found in the mucosal membranes of the large intestine
MP:0004843	abnormal Paneth cell morphology	any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine
MP:0004844	abnormal vestibuloocular reflex	any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system in which impulses are conveyed from the semicircular canals and the otolithic membrane to the oculomotor nerve; this stimulation may occur by angular acceleration or deceleration or by irrigation of the ear with hot or cold water; normally, this reflex functions to maintain a stable retinal image during head rotation by generating appropriate compensatory eye movements
MP:0004845	absent vestibuloocular reflex	absence of nystagmus or deviation of the eyes in response to stimulation of the vestibular system
MP:0004846	absent skeletal muscle	absence of any of the striated muscle fibers connected at either or both extremities with the bony framework of the body
MP:0004847	abnormal liver weight	anomaly in the average weight of the bile-secreting exocrine gland
MP:0004848	abnormal liver size	anomaly in the average size of the liver
MP:0004849	abnormal testis size	anomaly in the size of the male reproductive glands
MP:0004850	abnormal testis weight	anomaly in the average weight of the male reproductive glands
MP:0004851	increased testis weight	greater average weight of the male reproductive glands
MP:0004852	decreased testis weight	reduced average weight of the male reproductive glands
MP:0004853	abnormal ovary size	anomaly in the average size of the female reproductive gland containing the germ cells
MP:0004854	abnormal ovary weight	anomaly in the average weight of the female reproductive gland containing the germ cells
MP:0004855	increased ovary weight	greater average weight of the female reproductive gland containing the germ cells
MP:0004856	decreased ovary weight	reduction in the average weight of the female reproductive gland containing the germ cells
MP:0004857	abnormal heart weight	anomaly in the average weight of the heart compared to controls
MP:0004858	abnormal nervous system regeneration	anomaly in the renewal, repair, and/or regrowth of nervous system tissue following injury or disease
MP:0004859	abnormal synaptic plasticity	anomaly in the ability of a synapse to change its strength as a result of successive activations
MP:0004860	dilated kidney collecting duct	stretched or widened aperture of the luminal space of one or more of the kidney collecting ducts
MP:0004861	abnormal Raphe nucleus morphology	any structural anomaly of the subgroup of the reticular nuclei of the brain stem that are located in and along the median plane of the medulla oblongata, pons, and mesencephalon that include neurons that synthesize serotonin and extend ascending fibers to parts of the limbic system and descending fibers to other brain stem nuclei, the medulla oblongata, and the pons
MP:0004862	small scala tympani	volume reduction of the division of the spiral canal of the cochlea lying on the basal side of the spiral lamina
MP:0004863	thin spiral ligament	reduced thickness of the periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches
MP:0004864	spiral ligament degeneration	degeneration or loss of the thickened periosteal lining of the bony cochlea that forms the outer wall of the cochlear duct to which the basal lamina attaches
MP:0004865	abnormal platelet calcium level	anomaly in the amount in the platelet of calcium
MP:0004866	increased platelet calcium level	increased concentration in the platelet of calcium
MP:0004867	decreased platelet calcium level	decreased concentration in the platelet of calcium
MP:0004868	increased endometrial carcinoma incidence	greater than the expected number of a malignant neoplasm arising from the endometrial tissue, occurring in a specific population in a given time period
MP:0004869	frontal bone hypoplasia	decrease in the number of normal cells in normal arrangement in the frontal bone, typically resulting in decreased size
MP:0004870	small premaxilla	reduced size of the anterior and interior portion of the maxilla
MP:0004871	premaxilla hypoplasia	decrease in the number of normal cells in normal arrangement in the premaxilla, typically resulting in decreased size
MP:0004872	absent nasal septum	absence of the structure that separates the two nasal cavities
MP:0004873	absent turbinates	absence of the small curved bones that extend horizontally along the lateral wall of the nasal passage
MP:0004874	abnormal timing of postnatal eyelid opening	anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open
MP:0004875	increased mean systemic arterial blood pressure	increase in the average arterial pressure during a single cardiac cycle
MP:0004876	decreased mean systemic arterial blood pressure	decrease in the average arterial pressure during a single cardiac cycle
MP:0004877	abnormal systemic vascular resistance	anomaly in the normal force opposing blood flow in the peripheral blood vessels
MP:0004878	increased systemic vascular resistance	increase in the normal force opposing blood flow in the peripheral blood vessels
MP:0004879	decreased systemic vascular resistance	reduction in the normal force opposing blood flow in the peripheral blood vessels
MP:0004880	lung cyst	presence of one or more abnormal membranous or fluid-filled sacs in the lung
MP:0004881	abnormal lung size	anomaly in the size of the lung compared to controls
MP:0004882	enlarged lung	increased size of the lung compared to controls
MP:0004883	abnormal vascular wound healing	anomaly in the repair process of damaged blood vessels after injury
MP:0004884	abnormal testis physiology	any functional anomaly of the male reproductive glands
MP:0004885	abnormal endolymph physiology	any alteration in the normal production (volume) or ionic homeostasis of the fluid contained within the membranous labyrinth of the inner ear; unlike perilymph, endolymph resembles intracellular fluid in composition and has a high concentration of potassium ion and a low concentration of sodium ion
MP:0004886	increased endolymph production	increased synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear
MP:0004887	decreased endolymph production	reduced synthesis of the fluid that is normally contained within the membranous labyrinth of the inner ear
MP:0004888	abnormal perilymph physiology	change in the normal production (volume) or ionic homeostasis of the fluid contained within the osseous labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition, has a high concentration of sodium ion and a low concentration of potassium ion and, through the perilymphatic duct, is in continuity with cerebrospinal fluid
MP:0004889	increased energy expenditure	increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten
MP:0004890	decreased energy expenditure	decrease in the number of calories used per unit time or increase in weight gain for a given amount of food eaten
MP:0004891	abnormal adiponectin level	abnormal level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue
MP:0004892	increased adiponectin level	greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue
MP:0004893	decreased adiponectin level	reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue
MP:0004894	uterus atrophy	acquired diminution of the size of the uterus associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0004895	vagina atrophy	acquired diminution of the size of the vagina associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0004896	abnormal endometrium morphology	any structural anomaly of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy
MP:0004897	otosclerosis	formation of spongy bone in the bony labyrinth of the ear, especially adjacent to the footplate of the stapes; it may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis results in sensorineural hearing loss
MP:0004898	uterine hemorrhage	presence of bleeding in the uterus; often in response to failed pregnancy
MP:0004899	absent temporal bone squamous part	absence of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault
MP:0004900	absent zygomatic arch	absence of the bony arch that extends along the side or front of the skull beneath the eye socket and is formed by the temporal process of the zygomatic bone and the zygomatic process of the temporal bone
MP:0004901	decreased male germ cell number	reduced numbers of male germ cells whether they are undifferentiated or fully differentiated
MP:0004902	abnormal uterus size	anomaly in the size of the female organ of gestation
MP:0004903	abnormal uterus weight	anomaly in the weight of the female organ of gestation
MP:0004904	increased uterus weight	increase in the weight of the female organ of gestation
MP:0004905	decreased uterus weight	reduction in the weight of the female organ of gestation
MP:0004906	enlarged uterus	increased size of the female muscular organ of gestation
MP:0004907	abnormal seminal vesicle size	anomaly in the size of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0004908	abnormal seminal vesicle weight	anomaly in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0004909	increased seminal vesicle weight	increase in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0004910	decreased seminal vesicle weight	reduction in the weight of one or both of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens
MP:0004911	absent mandibular condyloid process	absence of the round bump of bone and constricted neck portion that arises from the upper surface of the mandibular ramus (perpendicular portion) and articulates with the articular disk of the temporomandibular joint
MP:0004912	absent mandibular coronoid process	absence of the thin, flattened, triangular eminence that arises from the upper surface of the mandibular ramus (perpendicular portion)
MP:0004913	absent mandibular angle	absence of the portion of the mandible where the body of the mandible (horizontal portion) and the rami (perpendicular portions) meet; these normally unite nearly at right angles
MP:0004914	absent ultimobranchial body	absence of the outpocketing of the caudal-most branchial pouch of the embryo (interpreted as a fifth pouch in human or as the ventral component of the fourth pouch in mouse) that fuses with the thyroid diverticulum, ultimately giving rise to calcitonin-producing parafollicular cells (aka C-cells) which function in calcium homeostasis; in most mammals, these parafollicular cells fully disperse with the endodermally derived follicular cells of the thyroid by birth
MP:0004915	abnormal Reichert's cartilage morphology	any structural anomaly of the cartilage found in the mesenchyme of the second pharyngeal arch in the embryo from which develop the stapes, styloid process, lesser horn and upper part of the body of the hyoid bone; its proximal end gives rise to the stylohyoid ligament
MP:0004916	absent Reichert cartilage	absence of the cartilage normally found in the mesenchyme of the second branchial arch in the embryo, from which develop the stapes, the styloid processes, the stylohyoid ligaments, and the lesser cornua of the hyoid bone
MP:0004917	abnormal T cell selection	any anomaly in the process through which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation
MP:0004918	abnormal negative T cell selection	any anomaly in the process of elimination of immature T cells which react strongly with self-antigens
MP:0004919	abnormal positive T cell selection	any anomaly in the process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death
MP:0004920	increased placenta weight	increase in the weight of the organ of metabolic interchange between fetus and mother
MP:0004921	decreased placenta weight	reduction in the weight of the organ of metabolic interchange between fetus and mother
MP:0004922	abnormal common crus morphology	any structural anomaly in the united, nonampullary ends of the superior and posterior semicircular ducts of the inner ear
MP:0004923	absent common crus	absence of the united, nonampullary ends of the superior and posterior semicircular ducts in the inner ear
MP:0004924	abnormal behavior	any anomaly in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls
MP:0004925	decreased susceptibility to noise-induced hearing loss	less than normal reduction in hearing sensitivity following exposure to acute noise that is injurious to the cochlea
MP:0004926	abnormal epididymis size	anomaly in the size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004927	abnormal epididymis weight	anomaly in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004928	increased epididymis weight	increase in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004929	decreased epididymis weight	reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004930	small epididymis	decrease in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004931	enlarged epididymis	increase in the average size of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004932	epididymis hypoplasia	decrease in the number of normal cells in normal arrangement in the epididymis, typically resulting in decreased size
MP:0004933	abnormal epididymis epithelium morphology	any structural anomaly of the layer of secretory cells which lines the epididymis
MP:0004934	epididymis epithelium degeneration	pathological deterioration of the layer of secretory cells which lines the epididymis
MP:0004935	epididymis degeneration	pathological deterioration of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens
MP:0004936	impaired branching involved in ureteric bud morphogenesis	partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney
MP:0004937	dilated heart	stretched or widened aperture of one or more of the luminal spaces of the heart, usually with an increase in contained fluid
MP:0004938	dilated vasculature	stretched or widened aperture of the luminal space of one or more of the blood vessels
MP:0004939	abnormal B cell morphology	any structural anomaly of lymphocytes that expresses membrane-bound immunoglobulin complexes in the mature form, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
MP:0004940	abnormal B-1 B cell morphology	any structural anomaly of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas
MP:0004941	abnormal regulatory T cell morphology	any structural anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
MP:0004942	abnormal B cell selection	anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival
MP:0004943	abnormal B cell positive selection	any anomaly in the process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival
MP:0004944	abnormal B cell negative selection	any anomaly in the process through which B cells which react strongly with self-antigens are eliminated, usually through anergy or deletion
MP:0004945	abnormal bone resorption	anomaly in the process of degrading the organic and inorganic phases of bone by absorption, usually by the abnormal function or by absence of osteoclasts
MP:0004946	abnormal regulatory T cell physiology	any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or Tregs) and other T cell types that have suppressor function
MP:0004947	skin inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the skin
MP:0004948	abnormal neuronal precursor proliferation	any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division
MP:0004949	absent neuronal precursor cells	absence of the neuroblast embryonic cells that develop into nerve cells or neurons
MP:0004950	abnormal brain vasculature morphology	any structural anomaly of the blood vessel network of the brain
MP:0004951	abnormal spleen weight	anomaly in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets
MP:0004952	increased spleen weight	greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets
MP:0004953	decreased spleen weight	reduction in the average weight of the organ that functions to filter blood and to store red corpuscles and platelets
MP:0004954	abnormal thymus weight	anomaly in the average weight of the primary lymphoid organ that is required for maturation of T cells
MP:0004955	increased thymus weight	greater than average weight of the primary lymphoid organ that is required for maturation of T cells
MP:0004956	decreased thymus weight	reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells
MP:0004957	abnormal blastocyst morphology	any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo
MP:0004958	enlarged prostate gland	increased size of the gland in males that secretes part of the seminiferous fluid
MP:0004959	abnormal prostate gland size	anomaly in the average size of the gland in males that secretes part of the seminiferous fluid
MP:0004960	abnormal prostate gland weight	anomaly in the average weight of the gland in males that secretes part of the seminiferous fluid
MP:0004961	increased prostate gland weight	greater than average weight of the gland in males that secretes part of the seminiferous fluid
MP:0004962	decreased prostate gland weight	reduction in the average weight of the gland in males that secretes part of the seminiferous fluid
MP:0004963	abnormal blastocoele morphology	any structural anomaly the fluid-filled cavity of the blastocyst of the preimplantation embryo of mammals
MP:0004964	absent inner cell mass	absence of the cells of the blastocyst that develop into the body of the embryo
MP:0004965	inner cell mass degeneration	a retrogressive impairment of function or destruction of the cells of the blastocyst that develop into the body of the embryo
MP:0004966	abnormal inner cell mass proliferation	any anomaly in the ability of the inner cell mass population to undergo rapid expansion by cell division
MP:0004967	abnormal kidney epithelium morphology	any structural anomaly of the cellular avascular layer of the kidney luminar surfaces
MP:0004968	kidney epithelium hyperplasia	increase in the number of normal cells in normal arrangement in the kidney epithelium, typically resulting in increased size
MP:0004969	pale kidney	kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition
MP:0004970	kidney atrophy	acquired diminution of the size of the kidney associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0004971	dermal hyperplasia	increase in the number of normal cells in normal arrangement in the dermal layer of the skin, typically resulting in increased thickness
MP:0004972	abnormal regulatory T cell number	deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
MP:0004973	increased regulatory T cell number	greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
MP:0004974	decreased regulatory T cell number	reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
MP:0004975	absent regulatory T cells	absence of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity
MP:0004976	abnormal B-1 B cell number	deviation from the normal count of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity
MP:0004977	increased B-1 B cell number	greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity
MP:0004978	decreased B-1 B cell number	reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity
MP:0004979	abnormal neuronal precursor cell number	deviation from the normal count of the neuroblast embryonic cells that develop into nerve cells or neurons
MP:0004980	increased neuronal precursor cell number	increased number of the neuroblast embryonic cells that develop into nerve cells or neurons
MP:0004981	decreased neuronal precursor cell number	reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons
MP:0004982	abnormal osteoclast morphology	any structural anomaly of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0004983	abnormal osteoclast cell number	deviation from the average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0004984	increased osteoclast cell number	greater than average number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0004985	decreased osteoclast cell number	reduced number of the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0004986	abnormal osteoblast morphology	any structural anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell
MP:0004987	abnormal osteoblast cell number	deviation from the average number of the skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell
MP:0004988	increased osteoblast cell number	greater than average number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell
MP:0004989	decreased osteoblast cell number	reduction in the number of skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell
MP:0004990	abnormal ciliary ganglion morphology	any structural anomaly of the parasympathetic ganglia in the orbit behind the eye that receives preganglionic innervation through the oculomotor nerve
MP:0004991	decreased bone strength	reduced ability of bone to endure the application of force without yielding or breaking
MP:0004992	increased bone resorption	greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts
MP:0004993	decreased bone resorption	reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts
MP:0004994	abnormal brain wave pattern	any anomaly in the standard pattern of rhythmic and rapid fluctuation of electrical potential between parts of the brain, often visualized on an electroencephalogram (EEG); the pattern is often measured to diagnose neurological conditions such as seizure disorders (epilepsy)
MP:0004995	abnormal B cell clonal deletion	a defect in the process of removal by apoptosis of immature B lymphocytes that interact with self antigens during maturation
MP:0004996	abnormal CNS synapse formation	any anomaly in the process of generating the initial connections between an axon and effector tissue or neuron
MP:0004997	increased CNS synapse formation	greater frequency of the process of generating the initial connections between an axon and effector tissue or neuron
MP:0004998	decreased CNS synapse formation	a reduction in the frequency of the process of generating the initial connections between an axon and effector tissue or neuron
MP:0004999	abnormal blood-inner ear barrier function	anomaly in the function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier
MP:0005000	abnormal immune tolerance	anomaly in the process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it
MP:0005001	abnormal clonal deletion	a defect in the process of removal of immature lymphocytes that interact with self antigens during maturation
MP:0005002	abnormal T cell clonal deletion	a defect in the process of removal of immature T lymphocytes that interact with self antigens during maturation
MP:0005003	obsolete B cell clonal deletion abnormalities	OBSOLETE. a defect in the process of removal of immature B lymphocytes that interact with self antigens during maturation
MP:0005004	abnormal lymphocyte anergy	anomaly in the process of establishing a state of functional inactivation of self-reactive lymphocytes
MP:0005005	abnormal self tolerance	a defect in the normal lack of response to autologous (self) antigens
MP:0005006	abnormal osteoblast physiology	any functional anomaly of a skeletogenic cell that secretes osteoid, is capable of producing mineralized (hydroxyapatite) matrix, is located adjacent to or within osteoid tissue, and arises from the transformation of a preosteoblast cell
MP:0005009	obsolete congenital skeletal deformities	OBSOLETE. malformations of the bones/skeleton existing at birth
MP:0005010	abnormal CD8-positive, alpha beta T cell morphology	any structural anomaly of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
MP:0005011	increased eosinophil cell number	greater than normal eosinophil numbers
MP:0005012	decreased eosinophil cell number	fewer than normal eosinophil numbers
MP:0005013	increased lymphocyte cell number	greater than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
MP:0005014	increased B cell number	greater than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity
MP:0005015	increased T cell number	greater than normal T cell numbers
MP:0005016	decreased lymphocyte cell number	fewer than normal number of the cells involved in adaptive immune reactions of the body in most inflammatory and autoimmune diseases, including B cells, T cells and natural killer cells
MP:0005017	decreased B cell number	fewer than normal number of cells that are formed in the bone marrow, migrate to the peripheral lymphatic system, and mature into plasma cells or memory cells; these cells are involved in humoral immunity
MP:0005018	decreased T cell number	fewer than normal T cell numbers
MP:0005019	abnormal early pro-B cell	any structural anomaly of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain
MP:0005020	abnormal late pro-B cell	any structural anomaly of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain
MP:0005021	obsolete B lymphoblast abnormalities	OBSOLETE.
MP:0005022	abnormal immature B cell morphology	any structural anomaly of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity
MP:0005023	abnormal wound healing	aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means
MP:0005025	abnormal response to infection	any anomaly in the body's reaction to invasion and multiplication of microorganisms in its tissues, or the body's reaction to components of or toxins produced by pathogenic microorganisms
MP:0005026	decreased susceptibility to parasitic infection	reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites
MP:0005027	increased susceptibility to parasitic infection	greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites
MP:0005028	abnormal trophectoderm morphology	any structural anomaly outermost layer of cells in the blastodermic vesicle, which will develop into the trophoblast layer and then contact the endometrium and take part in establishing the embryo's means of nutrition
MP:0005029	abnormal amnion morphology	any structural anomaly of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected
MP:0005030	absent amnion	absence of the thin innermost layer of the extraembryonic membranes that contains the amniotic fluid; the membrane forms a closed sac in which the embryo and later, the fetus, is suspended and protected
MP:0005031	abnormal trophoblast layer morphology	any structural anomaly of the mesectodermal cell layer arising from the trophectoderm that erodes the uterine mucosa and contributes to the formation of the placenta
MP:0005032	abnormal ectoplacental cone morphology	any structural anomaly of the thickened trophoblast of the blastocyst in rodents that becomes the fetal portion of the placenta
MP:0005033	abnormal trophoblast giant cell morphology	anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta
MP:0005034	abnormal anus morphology	any structural anomaly of the lower opening of the digestive tract
MP:0005035	perianal ulcer	lesion around or near the anus
MP:0005036	diarrhea	abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel
MP:0005037	mucous diarrhea	presence of considerable mucous in the stools
MP:0005039	hypoxia	reduced oxygenation of body tissues resulting in the decreased pressure of this component of body gases; commonly due to hypoxemia
MP:0005040	abnormal MHC II cell surface expression on macrophages	anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface
MP:0005041	abnormal antigen presentation via MHC class II	anomaly in the process by which peptide, bound to major histocompatibility complex class II, is presented to lymphocytes at the surface of antigen presenting cells
MP:0005042	abnormal level of surface class II molecules	deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface
MP:0005043	defective assembly of class II molecules	impaired production of major histocompatibility complex class II molecules
MP:0005044	sepsis	presence of various pathogenic organisms, or their toxins, in the blood or tissues
MP:0005046	absent spleen white pulp	absence of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
MP:0005047	enlarged celiac lymph nodes	increased size of the celiac lymph nodes
MP:0005048	abnormal thrombosis	any anomaly in the formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements
MP:0005049	obsolete abnormal cytokine physiology	OBSOLETE. functional anomaly of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells
MP:0005050	obsolete abnormal chemotactic interleukin physiology	OBSOLETE. functional anomaly of any of a subset of interleukins that are involved in attracting leukocytes to a site of tissue injury
MP:0005051	obsolete altered response to anesthetics	OBSOLETE. a reaction that differs from normal to compounds that reversibly depress neuronal function
MP:0005052	obsolete increased sleep after pentobarbital treatment	OBSOLETE.
MP:0005053	obsolete altered response to pentobarbital	OBSOLETE. a reaction to pentobarbital that differs from normal
MP:0005054	obsolete altered response to tribromoethanol	OBSOLETE. a reaction to tribromoethanol that differs from normal
MP:0005055	obsolete altered response to alphaxalone	OBSOLETE. a reaction to alphaxalone that differs from controls
MP:0005056	obsolete increased sleep after tribromoethanol treatment	OBSOLETE.
MP:0005057	obsolete increased sleep after alphaxalone treatment	OBSOLETE.
MP:0005058	abnormal lysosome morphology	any structural anomaly of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases
MP:0005059	lysosomal protein accumulation	buildup of protein in the lysosome
MP:0005060	accumulation of giant lysosomes in kidney/renal tubule cells	buildup of contents in lysosomes in cells of the kidney tubules
MP:0005061	abnormal eosinophil morphology	any structural anomaly of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin and is involved in clearance of parasitic infections and in allergic reactions
MP:0005062	obsolete presence of giant granules in eosinophils	OBSOLETE.
MP:0005064	obsolete presence of giant granules in lymphocytes	OBSOLETE.
MP:0005065	abnormal neutrophil morphology	any structural anomaly of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes
MP:0005066	obsolete presence of giant granules in neutrophils	OBSOLETE.
MP:0005067	obsolete presence of melanin granules in retina	OBSOLETE. pigment particles found in retina
MP:0005068	abnormal NK cell morphology	any structural anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0005070	impaired natural killer cell mediated cytotoxicity	impaired ability of directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors
MP:0005071	enlarged hair follicle melanin granules	increased size of the pigment particles located in the hair follicle
MP:0005072	abnormal hair follicle melanin granule morphology	any structural anomaly of the pigment particles in the hair follicles
MP:0005074	impaired granulocyte bactericidal activity	inability or reduced ability of neutrophils, eosinophils, or basophils to kill bacteria
MP:0005075	abnormal melanosome morphology	any structural anomaly of the tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored
MP:0005076	abnormal cell differentiation	anomaly in the process whereby relatively unspecialized cells, e. g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history
MP:0005077	abnormal melanogenesis	anomaly in the biosynthetic pathway of melanin formation in cells
MP:0005078	abnormal cytotoxic T cell physiology	any functional anomaly of the subset of CD8-positive T lymphocytes capable of directly killing appropriately targeted cells
MP:0005079	decreased cytotoxic T cell cytolysis	impaired ability of cytotoxic T cells to induce pathological breakdown of target cells by the destruction of their outer membrane
MP:0005081	abnormal dermis reticular layer morphology	any structural anomaly of the thicker, deeper layer of the dermis, comprised of criss-crossing collagen fibers that form a strong elastic network and also containing blood and lymph vessels, nerves and nerve endings, and hair follicles
MP:0005083	abnormal biliary tract morphology	any structural anomaly of the gall bladder or its bile ducts
MP:0005084	abnormal gallbladder morphology	any structural anomaly of the organ which serves as a storage reservoir for bile
MP:0005085	abnormal gallbladder physiology	any functional anomaly of the organ that stores and concentrates bile
MP:0005087	decreased acute inflammation	less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response
MP:0005088	increased acute inflammation	greater than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response
MP:0005089	decreased double-negative T cell number	reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8
MP:0005090	increased double-negative T cell number	greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8
MP:0005091	increased double-positive T cell number	greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8
MP:0005092	decreased double-positive T cell number	less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8
MP:0005093	decreased B cell proliferation	absent or reduced expansion rate of the B cell population by cell division in response to stimuli
MP:0005094	abnormal T cell proliferation	anomaly in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli
MP:0005095	decreased T cell proliferation	reduction in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli
MP:0005096	erythroblastosis	presence of erythroblasts in great number in the blood
MP:0005097	polychromatophilia	condition characterized by the presence of red blood cells that have an affinity for acid, basic, and neutral stains
MP:0005098	abnormal optic choroid morphology	any structural anomaly of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera
MP:0005099	abnormal ciliary body morphology	any structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris, and is made up of the ciliary muscle and the ciliary processes; the processes radiate from the ciliary muscle and give attachments to ligaments supporting the lens of the eye
MP:0005100	abnormal choroid pigmentation	anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera
MP:0005101	abnormal ciliary body pigmentation	anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris
MP:0005102	abnormal iris pigmentation	anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye
MP:0005103	abnormal retina pigmentation	anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors
MP:0005104	abnormal tarsal bone morphology	any structural anomaly of any of the eight bones of the instep of the paw/foot: tibiale, talus, calcaneus, navicular, 3 cuneiform, and cuboid bones
MP:0005105	abnormal middle ear ossicle morphology	any structural anomaly of the three small bones of the middle ear
MP:0005106	abnormal incus morphology	any structural anomaly of the anvil-shaped, central bone of the three auditory ossicles which articulates with the head of the malleus anteromedially and the stapes inferomedially; its parts include: a body which articulates with the head of the malleus, and to which the superior ligament of the incus is attached (to the roof of the middle ear cavity); a long crus down to the lentiform process (lenticular process) which articulates with the stapes; and a short crus to which the posterior ligament of the incus is attached
MP:0005107	abnormal stapes morphology	any structural anomaly of the smallest and innermost of the three auditory ossicles
MP:0005108	abnormal ulna morphology	any structural anomaly of the medial and larger of the two bones of the forearm
MP:0005109	abnormal talus morphology	any structural anomaly of the bone that articulates with the tibia and fibula
MP:0005110	absent talus	absence of the bone that articulates with the tibia and fibula
MP:0005111	hyperdipsia	intense thirst that is relatively temporary
MP:0005112	abnormal spinal cord ventral horn morphology	any structural anomaly of the ventral grey column of the spinal cord
MP:0005113	decreased spinal cord ventral horn cell number	fewer than the expected number of cells in the ventral grey column of the spinal cord
MP:0005114	premature hair loss	release of fur at an earlier than expected time
MP:0005116	abnormal circulating pituitary hormone level	aberration in the blood concentration of any of the hormones secreted by the pituitary
MP:0005117	increased circulating pituitary hormone level	greater than expected concentration of any of the pituitary hormones in the blood
MP:0005118	decreased circulating pituitary hormone level	less than expected concentration of any of the pituitary hormones found in the blood
MP:0005119	decreased circulating thyroid-stimulating hormone level	reduced amount in the blood of the hormone that stimulates the growth and function of the thyroid gland
MP:0005120	decreased circulating growth hormone level	less than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization
MP:0005121	decreased circulating prolactin level	less than expected blood concentration of the hormone that stimulates milk secretion
MP:0005122	increased circulating thyroid-stimulating hormone level	greater amount in the blood of the hormone that stimulates the growth and function of the thyroid gland
MP:0005123	increased circulating growth hormone level	greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization
MP:0005124	increased circulating prolactin level	greater than expected blood concentration of the hormone that stimulates milk secretion
MP:0005128	decreased adrenocorticotropin level	decreased concentration of adrenocorticotropic hormone
MP:0005129	increased adrenocorticotropin level	increased concentration of adrenocorticotropic hormone
MP:0005130	decreased follicle stimulating hormone level	less than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0005131	increased follicle stimulating hormone level	greater than expected concentration of the hormone that, in females, stimulates the graafian follicles of the ovary and assists in follicular maturation and the secretion of estradiol; in the male it stimulates the epithelium of the seminiferous tubules and is partly responsible for spermatogenesis
MP:0005132	decreased luteinizing hormone level	lower than normal concentration of LH
MP:0005133	increased luteinizing hormone level	higher than normal levels of LH
MP:0005134	decreased thyroid-stimulating hormone level	reduced amount of the hormone that stimulates the growth and function of the thyroid gland
MP:0005135	increased thyroid-stimulating hormone level	greater amount of the hormone that stimulates the growth and function of the thyroid gland
MP:0005136	decreased growth hormone level	less than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization
MP:0005137	increased growth hormone level	greater than the expected concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization
MP:0005138	decreased prolactin level	less than expected concentration of the hormone that stimulates milk secretion
MP:0005139	increased prolactin level	greater than expected concentration of the hormone that stimulates milk secretion
MP:0005140	decreased cardiac muscle contractility	inability or reduced ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
MP:0005141	liver hyperplasia	increase in the number of normal cells in normal arrangement in the liver, typically resulting in increased size
MP:0005144	abnormal circulating VLDL cholesterol level	any anomaly in the amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue
MP:0005145	increased circulating VLDL cholesterol level	greater amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue
MP:0005146	decreased circulating VLDL cholesterol level	reduced amount in the blood of the lipoprotein:cholesterol complex that transports triglycerides from the intestine and liver to muscle and adipose tissue
MP:0005147	prostate gland hypoplasia	decrease in the number of normal cells in normal arrangement in the prostate gland, typically resulting in decreased size
MP:0005148	seminal vesicle hypoplasia	decrease in the number of normal cells in normal arrangement in the seminal vesicle, typically resulting in decreased size
MP:0005149	abnormal gubernaculum morphology	any structural anomaly of the genitoinguinal ligaments that, in the male, connect the fetal testis to the developing scrotum, and, in the female, connect the ovaries to the uterus
MP:0005150	cachexia	general weight loss and wasting occurring in the course of chronic disease
MP:0005151	diffuse hepatic necrosis	morphological changes resulting from disseminated pathological death of some or all liver tissue; usually due to irreversible damage
MP:0005152	pancytopenia	reduction in the number of erythrocytes, all types of white blood cells, and platelets in the circulating blood
MP:0005153	abnormal B cell proliferation	anomaly in the ability of the B cell population to undergo rapid expansion by cell division in response to stimuli
MP:0005154	increased B cell proliferation	greater than normal expansion rate of the B cell population by cell division in response to stimuli
MP:0005155	herniated intestine	protrusion of any portion of the intestine from its normal anatomical position
MP:0005156	bradykinesia	decreased spontaneity and movement, without external stimulus
MP:0005157	holoprosencephaly	presence of a single forebrain hemisphere or lobe; often accompanied by a deficit in median facial development
MP:0005158	ovary hypoplasia	decrease in the number of normal cells in normal arrangement in the ovary, typically resulting in decreased size
MP:0005159	azoospermia	a condition where there is no measurable level of spermatozoa in the semen
MP:0005161	hematuria	presence of blood in the urine
MP:0005162	carpoptosis	paralysis of the extensors of the wrist and fingers; most often caused by a lesion of the radial nerve
MP:0005163	cyclopia	a congenital defect characterized by the failure of the embryonic prosencephalon to properly divide the orbits of the eye into two cavities; cyclopia is a rare form of holoprosencephaly that typically presents with a median single eye or a partially divided eye in a single orbit, absent nose, and a proboscis above the eye
MP:0005164	abnormal response to injury	anomaly in the body's reaction to trauma, especially that by physical means
MP:0005165	increased susceptibility to injury	greater than the normal reaction to trauma, especially that by physical means
MP:0005166	decreased susceptibility to injury	less than the normal reaction to trauma, especially that by physical means
MP:0005167	abnormal blood-brain barrier function	anomaly in the function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood
MP:0005168	abnormal female meiosis	anomaly in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell
MP:0005169	abnormal male meiosis	anomaly in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell
MP:0005170	cleft upper lip	defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences
MP:0005171	absent coat pigmentation	fur or hair is devoid of coloration and appears white
MP:0005172	decreased eye pigmentation	the eye has less pigmentation than normal with a possible range of color from dark red, somewhat reduced in pigment, to pink, typical of albinism or ocular albinism
MP:0005174	abnormal tail pigmentation	anomaly in the coloration of the tail due to changes in the amount, shape, or distribution of cells producing pigment
MP:0005175	non-pigmented tail tip	lack of color at the end of the tail
MP:0005176	eyelids fail to open	eyes remain shut when eyelids are expected to be open
MP:0005178	increased circulating cholesterol level	greater than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0005179	decreased circulating cholesterol level	less than the normal amount in the blood of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0005180	abnormal circulating testosterone level	anomaly in the blood concentration of a potent androgen that promotes development of male secondary sex characteristics and the development of spermatozoa and may regulate sexual desire and help maintain bone and muscle health in both males and females
MP:0005181	decreased circulating estradiol level	less than the normal blood concentration of this most potent naturally occurring estrogen in mammals
MP:0005182	increased circulating estradiol level	greater than the normal blood concentration of this most potent naturally occurring estrogen in mammals
MP:0005183	abnormal circulating estradiol level	aberration in the blood concentration of this most potent estrogen
MP:0005184	abnormal circulating progesterone level	anomaly in the blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy
MP:0005185	decreased circulating progesterone level	reduced blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy
MP:0005186	increased circulating progesterone level	increased blood concentration of the antiestrogenic steroid released by the corpus luteum that stimulates the uterus to prepare for pregnancy
MP:0005187	abnormal penis morphology	any structural anomaly of the organ of copulation and urination in the male
MP:0005188	small penis	reduced size of the organ of copulation and urination in the male
MP:0005189	abnormal anogenital distance	in comparison to the norm, aberration in the measure of the length of space from the genitals to the anus
MP:0005190	osteomyelitis	bone inflammation
MP:0005191	head tilt	condition in which the portion of the body containing the brain and organs of sight, hearing, taste, and smell lists to the side
MP:0005192	increased motor neuron number	greater than the normal number of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses
MP:0005193	abnormal anterior eye segment morphology	any structural anomaly of any of the parts of the eye that lie in front of, or ventral to, the lens (inclusive)
MP:0005194	abnormal anterior uvea morphology	any structural anomaly of any of the parts of the front, or ventral, portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris
MP:0005195	abnormal posterior eye segment morphology	any structural anomaly of any of the parts of the eye that lie in back of, or dorsal to, the lens (but not inclusive)
MP:0005196	obsolete abnormal posterior uvea morphology	any structural anomaly of the rear, or dorsal, portion of the vascular, pigmentary, or middle coat of the eye, includes the choroid
MP:0005197	abnormal uvea morphology	any structural anomaly of the pigmented vascular coat of the eyeball, consisting of the iris, ciliary body, and choroid
MP:0005198	abnormal aqueous drainage system morphology	any structural anomaly of the structures associated with drainage of the aqueous humor from the eye, that include the trabecular meshwork, Schlemm's canal, the uveoscleral network, and the aqueous veins
MP:0005199	abnormal iris pigment epithelium	anomaly in the epithelial layer of the iris composed of cells containing pigment granules
MP:0005200	obsolete abnormal eye pigment epithelium morphology	OBSOLETE. any structural anomaly in the epithelial layer of the retina, ciliary body, or iris composed of cells containing pigment granules
MP:0005201	abnormal retina pigment epithelium morphology	any structural anomaly in the epithelial layer of the retina composed of cells containing pigment granules
MP:0005202	lethargy	mild impairment of consciousness resulting in reduced alertness and awareness and/or sluggish behavior or inactivity; can be due to generalized brain dysfunction
MP:0005203	abnormal trabecular meshwork morphology	any structural anomaly in the pore-like structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates
MP:0005204	abnormal canal of Schlemm morphology	any structural anomaly in the vascular structure encircling the anterior chamber of the eye, through which the aqueous humor is returned to the blood circulation
MP:0005205	abnormal eye anterior chamber morphology	any structural anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens
MP:0005206	abnormal aqueous humor	anomaly in the clear, watery fluid that fills the anterior and posterior chambers of the eye
MP:0005207	abnormal aqueous vein morphology	any structural anomaly of this vessel that receives aqueous humor from the sinus venosus sclerae (canal of Schlemm)
MP:0005208	abnormal iris stroma morphology	any structural anomaly of the lamellated vascular connective tissue of the iris
MP:0005210	disorganized stomach mucosa	derangement of the pattern of the mucous layer of the stomach wall
MP:0005211	increased stomach mucosa thickness	greater than the normal depth or width of the of the mucous layer of the stomach wall
MP:0005212	obsolete immature goblet-like cells in stomach	OBSOLETE. unusual appearance of stomach mucosa in which one finds cells resembling those that produce and secrete mucins
MP:0005213	gastric metaplasia	condition in which there is a change of one adult cell type to another adult cell type in the stomach
MP:0005214	regional gastric metaplasia	localized areas of the stomach in which there is a change from one adult cell type to another adult cell type
MP:0005215	abnormal pancreatic islet morphology	any structural anomaly of the clusters of hormone-producing cells that are scattered throughout the pancreas
MP:0005216	abnormal pancreatic alpha cell morphology	any structural anomaly of the cells of the pancreas that secrete glucagon
MP:0005217	abnormal pancreatic beta cell morphology	any structural anomaly of a cell that secretes insulin and is located towards the center of the islets of Langerhans in the pancreas
MP:0005218	abnormal pancreatic delta cell morphology	any structural anomaly of the cells found in the pancreas that secrete somatostatin
MP:0005220	abnormal exocrine pancreas morphology	any structural anomaly of the acinar gland portion of the pancreas that secretes digestive enzymes
MP:0005221	abnormal rostral-caudal axis patterning	anomaly in the development or formation of the axis that runs from the head to the tail of the body
MP:0005222	abnormal somite size	atypical size of any of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo
MP:0005223	abnormal dorsal-ventral polarity of the somites	anomalous development or formation of the pattern of somites along the axis that runs from the front (ventral) to the back (dorsal) surface of the body
MP:0005224	abnormal left-right axis symmetry of the somites	anomaly in the formation or development of the somites in relation to the left and right sides of the body
MP:0005225	abnormal vertebrae development	anomalous formation of the vertebrae from the sclerotome
MP:0005226	abnormal vertebral arch development	anomalous formation of the posterior projection from the body of a vertebra that encloses the vertebral foramen
MP:0005227	abnormal vertebral body development	anomalous formation of the main portion of the vertebra anterior to the vertebral canal, and distinct from the vertebral arch
MP:0005228	obsolete abnormal fusion of vertebral bodies/neural arches	OBSOLETE. improper joining of the main portion of the vertebra anterior to the vertebral canal and the cartilaginous or bony arch that encloses and protects the spinal cord on the back
MP:0005229	abnormal intervertebral disk development	any anomaly in the formation of the cartilaginous and gelatinous structure found between vertebrae
MP:0005230	ectrodactyly	absence of the middle rays, i.e., the central digits; usually associated with cleft hands/feet and may also include syndactyly or aplasia of remaining digits
MP:0005231	abnormal brachial lymph node morphology	any structural anomaly of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes
MP:0005232	abnormal mesenteric lymph node morphology	any structural anomaly of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group
MP:0005235	obsolete abnormal olfactory pathway morphology	OBSOLETE. any structural anomaly of any of the set of nerve fibers conducting impulses from olfactory receptors to the cerebral cortex, including the olfactory nerve; olfactory bulb; olfactory tract, olfactory tubercle, anterior perforated substance, and olfactory cortex
MP:0005236	abnormal olfactory nerve morphology	any structural anomaly of the first cranial nerve, which conveys the sense of smell
MP:0005237	abnormal olfactory tract morphology	any structural anomaly of the nerve-like, white band composed primarily of nerve fibers originating from the mitral cells and tufted cells of the olfactory bulb, but also containing the scattered cells of the anterior olfactory nucleus
MP:0005238	increased brain size	larger than the normal physical proportions of the brain
MP:0005239	abnormal Bruch membrane morphology	any structural anomaly of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina
MP:0005240	abnormal amacrine cell morphology	any structural anomaly of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer
MP:0005241	abnormal retina ganglion layer morphology	any structural anomaly of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain
MP:0005242	cryptophthalmos	congenital anomaly in which the skin is continuous over the eyeball without any indication of the formation of eyelids
MP:0005243	hemothorax	bleeding into the pleural space
MP:0005244	hemopericardium	bleeding into the pericardial space
MP:0005245	hemarthrosis	bleeding into a joint space
MP:0005247	abnormal extraocular muscle morphology	any structural anomaly of any of the striated muscles that are located within the orbit but are extrinsic and separate from the eyeball itself and control the movements of the eyeball and the superior eyelid; there are seven extraocular muscles: superior rectus, inferior rectus, medial rectus, lateral rectus, inferior oblique, superior oblique, and levator palpebrae superioris
MP:0005248	abnormal Harderian gland morphology	any structural anomaly of the retroocular sebaceous gland found within the orbit of mammals that possess a nictitating membrane (third eyelid); the chief products of the gland vary between different groups of vertebrates, and epithelial cells possess granules or vacuoles whose contents may be mucous, serous or lipid; in rodents, the Harderian gland is especially large and secretes lipids (by a merocrine mechanism), melatonin and porphyrins; ascribed functions include a role in lubrication and protection for the eyeball and nictitating membrane (by lipids), photoprotection (by porphyrin), photoreception (by regulation of the incidence of light on the retina), and thermoregulation (in some rodents) of the sebaceous gland located behind the eyeball that excretes fluid that facilitates movement of the nictitating membrane
MP:0005249	abnormal palatine bone morphology	any structural anomaly of either of two irregularly L-shaped bones located posterior to the maxilla that in part forms the back of the hard palate, part of the nasal cavity and part of the floor of the orbits
MP:0005250	decreased Sertoli cell number	decreased number of the supporting cells of the seminiferous tubules that create the blood-testes barrier and enable spermatogenesis
MP:0005251	blepharitis	inflammation of the eyelids
MP:0005252	abnormal Meibomian gland morphology	any structural anomaly of the sebaceous glands embedded in the tarsal plate of each eyelid
MP:0005253	abnormal eye physiology	any functional anomaly and/or activity of the spheroid organ and optic nerve that serves to detect light
MP:0005254	strabismus	misalignment of the visual axes of the eyes
MP:0005255	exotropia	a form of ocular misalignment in which the lateral rectus muscle pulls the eye in an outward direction
MP:0005256	esotropia	a form of ocular misalignment in which there is excessive convergence of the visual axes, giving a cross-eyed appearance
MP:0005257	abnormal intraocular pressure	anomaly in the amount of force per unit area exerted by the intraocular fluid within the eye
MP:0005258	ocular hypertension	abnormal elevation of the intraocular pressure
MP:0005260	ocular hypotension	abnormally low intraocular pressure
MP:0005261	aniridia	abnormality in which there is only a rudimentary iris, due to the failure of optic cup growth
MP:0005262	coloboma	anomaly in which some of the structures of the eye are absent due to incomplete fusion of the fetal intraocular fissure during gestation
MP:0005263	obsolete ectopia lentis	OBSOLETE. congenital displacement of the lens due to defective zonule formation
MP:0005264	glomerulosclerosis	hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes
MP:0005265	abnormal blood urea nitrogen level	aberrant circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function
MP:0005266	abnormal metabolism	any anomaly in the processes that cause many of the chemical changes in living organisms, including anabolism and catabolism; metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation
MP:0005267	abnormal olfactory cortex morphology	any structural anomaly of cortex area which receives its major afferents from the olfactory bulb, and is primarily responsible for the identification of odors
MP:0005269	abnormal occipital bone morphology	any structural anomaly of the bone at the lower, posterior part of the skull
MP:0005270	abnormal zygomatic bone morphology	any structural anomaly of the quadrilateral bone that forms the prominence of the cheek
MP:0005271	abnormal lacrimal bone morphology	any structural anomaly of the irregularly thin plate that forms part of the medial wall of the orbit behind the frontal process of the maxilla
MP:0005272	abnormal temporal bone morphology	any structural anomaly of the large, irregular bone located at the base and side of the skull; consists of three parts at birth: squamous, tympanic, and petrous
MP:0005274	abnormal viscerocranium morphology	any structural anomaly of the part of the skull that comprises the facial bones
MP:0005275	abnormal skin tensile strength	change from the normal maximum tension the skin can withstand without tearing
MP:0005277	abnormal brainstem morphology	any structural anomaly of the stalk-like part of the brain that comprises the midbrain (aka mesencephalon), the pons (aka pons Varolii), and the medulla oblongata, and connects the cerebral hemispheres with the cervical spinal cord
MP:0005278	abnormal cholesterol homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of cholesterol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues
MP:0005279	narcolepsy	recurring episodes of sleep during normal waking hours and often disrupted sleep during normal sleeping period; often accompanied by cataplexy, sleep paralysis and hallucinations
MP:0005280	abnormal fatty acids level	any anomaly in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated
MP:0005281	increased fatty acids level	elevated concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated
MP:0005282	decreased fatty acids level	reduction in the concentration of aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; natural fatty acids commonly have a chain of 4 to 28 carbons (usually unbranched and even-numbered), which may be saturated or unsaturated
MP:0005283	increased unsaturated fatty acids level	elevated concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms
MP:0005284	increased saturated fatty acids level	elevated concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms
MP:0005285	decreased unsaturated fatty acids level	reduced concentration of unsaturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; unsaturated fatty acids commonly have a chain of 4 to 28 carbons which possess one or more double or triple bonds between carbon atoms
MP:0005286	decreased saturated fatty acids level	reduced concentration of saturated aliphatic monocarboxylic acids derived from or contained in esterified form in an animal or vegetable fat, oil or wax; saturated fatty acids commonly have a chain of 4 to 28 carbons which contains no ethylenic or other unsaturated linkages between carbon atoms
MP:0005287	narrow eye opening	less than the normal distance from one eyelid to the other without fusion of the eyelid margins
MP:0005288	abnormal oxygen consumption	deviation from the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body
MP:0005289	increased oxygen consumption	greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body
MP:0005290	decreased oxygen consumption	less than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body
MP:0005291	abnormal glucose tolerance	deviation from the normal response to oral consumption or intravenous injection of specified amounts of glucose; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals
MP:0005292	improved glucose tolerance	better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals
MP:0005293	impaired glucose tolerance	less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals
MP:0005294	abnormal heart ventricle morphology	any structural anomaly of one or both of the two lower chambers of the heart
MP:0005296	abnormal humerus morphology	any structural anomaly of the bone of the forelimb that articulates with the scapula above and the radius and ulna below
MP:0005297	spina bifida occulta	defective closure of the laminae of the vertebral column in the lumbosacral region without hernial protrusion of the spinal cord or meninges; the mildest, most common and often asymptomatic form of spina bifida, identified externally by a skin depression or dimple, dark tufts of hair, telangiectasis, or soft subcutaneous lipomas at the site of defect
MP:0005298	abnormal clavicle morphology	any structural anomaly of the doubly curved long bone that forms part of the shoulder girdle and articulates with the sternum and the scapula
MP:0005299	abnormal eye posterior chamber morphology	any structural anomaly of the ring-like space, filled with aqueous humor, between the iris/pupil anteriorly and the lens and ciliary body posteriorly
MP:0005300	abnormal cornea stroma morphology	any structural anomaly of the lamellated connective tissue of the cornea between the Bowman and Descemet membranes
MP:0005301	abnormal cornea endothelium morphology	any structural anomaly of the single layer of large flattened cells that cover the surface of the cornea
MP:0005302	neurogenic bladder	defective functioning of the bladder due to impaired innervation, either within the CNS or the PNS
MP:0005304	bulbourethral gland cyst	presence of one or more membrane-lined sacs containing gas, fluid, or semisolid matter in the bulbourethral gland
MP:0005305	prostate gland anterior lobe hyperplasia	increase in the number of normal cells in normal arrangement in the prostate gland anterior lobe, typically resulting in increased size
MP:0005306	abnormal phalanx morphology	any structural anomaly of any of the long bones of the digits
MP:0005307	head tossing	repetitive flailing of the head in multiple directions
MP:0005308	abnormal circulating ammonia level	aberrant amount of ammonia or its compounds in blood, formed in the body during organic decomposition
MP:0005309	increased circulating ammonia level	significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy
MP:0005310	abnormal salivary gland physiology	any functional anomaly of any of the glands in the mouth that secrete saliva
MP:0005311	abnormal circulating amino acid level	any anomaly in the amount in the blood of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group
MP:0005312	pericardial effusion	escape of fluid from blood vessels or lymphatic vessels into the fibrous sac surrounding the heart
MP:0005313	absent adrenal gland	absence of the pair of endocrine glands located above the kidney that are responsible for steroid hormone secretion from the cortex and neurotransmitter (such as epinephrine and norepinephrine) secretion from the medulla
MP:0005314	absent thyroid gland	lack of the endocrine gland that is normally located in the front and to the sides of the upper part of the trachea and which secretes thyroid hormone and calcitonin
MP:0005315	absent pituitary gland	lack of the gland that is normally suspended from the base of the hypothalamus and which secretes somatotropins, prolactin, TSH (thyroid-stimulating hormone), gonadotropins, adrenal corticotropin
MP:0005316	abnormal response to tactile stimuli	anomaly in the reflex action normally induced by touch or pain
MP:0005317	increased triglyceride level	greater concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver
MP:0005318	decreased triglyceride level	reduced concentration of naturally occurring esters of three fatty acids and glycerol; triglycerides are widespread in adipose tissue, commonly circulate in the blood in the form of lipoproteins, and are involved in the process of bidirectional transference of adipose fat and blood glucose with the liver
MP:0005319	abnormal enzyme/coenzyme level	altered level of any enzyme or their cofactors, that act as catalysts to induce chemical changes in other substances
MP:0005320	abnormal biopterin level	anomaly in the concentration of this pterin found in yeast, the fruit fly and in normal human urine, the reduced form of which acts as a coenzyme for many enzymatic reactions
MP:0005321	abnormal neopterin level	anomaly in the concentration of a pteridine derivative, which is present in body fluids and is a precursor in the biosynthesis of biopterin; elevated levels result from immune activation, malignant disease, allograft rejection, and viral infection
MP:0005322	abnormal serotonin level	anomaly in the amount of biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity
MP:0005323	dystonia	impairment of muscle tone resulting in prolonged muscle contraction and involuntary movements such as repetitive movements, or twisting or writhing of the limbs
MP:0005324	ascites	accumulation or retention of fluid within the peritoneal cavity
MP:0005325	abnormal renal glomerulus morphology	any structural anomaly of the tuft formed of capillary loops and mesangium at the beginning of each nephretic tubule in the kidney that normally function as a filtration unit
MP:0005326	abnormal podocyte morphology	any structural anomaly of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane
MP:0005327	abnormal mesangial cell morphology	any structural anomaly of the modified smooth muscle cells that are interposed between endothelial cells and the basement membrane in the central or stalk region of the capillary tuft of the renal glomerulus, which regulate blood flow by their contractile activity, and secrete extracellular matrix, prostaglandins, and cytokines; mesangial cells also have phagocytic activity, removing proteins and other molecules trapped in the glomerular basement membrane or filtration barrier
MP:0005328	abnormal circulating creatinine level	anomaly in the blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction
MP:0005329	abnormal myocardium layer morphology	any structural anomaly of the middle layer of the heart, comprised mainly of striated cardiac muscle fibers
MP:0005330	cardiomyopathy	diseases of the heart (myocardium); may result from many causes
MP:0005331	insulin resistance	diminished effectiveness of insulin in lowering plasma glucose levels
MP:0005332	abnormal amino acid level	any anomaly in the amount of a carboxylic acid containing one or more amino groups (-NH2) and a carboxyl (-COOH) group
MP:0005333	decreased heart rate	fewer than average resting heart beats per minute, usually measured by the number of times the heart ventricles contract per unit of time, usually per minute
MP:0005334	abnormal fat pad morphology	any structural anomaly of the encapsulated adipose tissue
MP:0005335	abnormal gonadal fat pad morphology	any structural anomaly of the encapsulated adipose tissue associated with the ovaries or testes
MP:0005336	abnormal inguinal fat pad morphology	any structural anomaly of the encapsulated adipose tissue found in the groin
MP:0005337	abnormal retroperitoneal fat pad morphology	any structural anomaly of the encapsulated adipose tissue found on the dorsal side of the peritoneum
MP:0005338	atherosclerotic lesions	thickening and loss of elasticity of arterial walls, involving plaque-like lipid deposition and thickening of intimal layers within arteries; progresses to narrowing of arterial lumens with fibrosis and calcification resulting in restriction of blood flow
MP:0005339	increased susceptibility to atherosclerosis	more likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries
MP:0005340	abnormal susceptibility to atherosclerosis	a change in the likelihood that an organism will develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries
MP:0005341	decreased susceptibility to atherosclerosis	less likely than normal to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries
MP:0005342	abnormal intestinal lipid absorption	any anomaly in the ability of the body to take up lipids into the blood by absorption from the small intestine
MP:0005343	increased circulating aspartate transaminase level	greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction
MP:0005344	increased circulating bilirubin level	increased concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells
MP:0005345	abnormal circulating corticosterone level	anomaly in the amount of the adrenocortical steroid in the blood that induces glycogen deposition and regulates sodium conservation and potassium secretion
MP:0005346	abnormal circulating aldosterone level	anomaly in the blood concentration of the hormone that is secreted by the adrenal cortex and regulates sodium conservation and potassium secretion in the distal renal tubule
MP:0005348	increased T cell proliferation	increase in the ability of a naive T cell population to undergo rapid expansion by cell division in response to stimuli
MP:0005349	obsolete abnormal interleukin-6 physiology	OBSOLETE. functional anomaly of this soluble factor produced by B- and T-cells, with effects on T- and B-cell growth and differentiation, and in acute phase reactions
MP:0005350	increased susceptibility to autoimmune disorder	greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides
MP:0005351	decreased susceptibility to autoimmune disorder	reduced likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides
MP:0005352	small cranium	reduced size of the cranium
MP:0005353	abnormal patella morphology	any structural anomaly of the large sesamoid bone that covers the anterior surface of the knee
MP:0005354	abnormal ilium morphology	any structural anomaly of the broad, flaring portion of the hip bone, which is distinct at birth, but later fuses with the ischium and the pubis
MP:0005355	enlarged thyroid gland	increased size of the endocrine gland located in the front and to the sides of the upper part of the trachea, and which secretes thyroid hormone and calcitonin
MP:0005356	positive geotaxis	mice, when placed on a downward on a slanting grid, walk down without turning around, or exhibit a delay in turning around, whereas wild type mice will always turn around and walk upward
MP:0005357	novel environmental response-related retropulsion	when confronted with a novel stimulus, subjects exhibit involuntary backward walking
MP:0005358	abnormal incisor morphology	any structural anomaly of the long teeth, normally consisting of two pairs, top and bottom, that are the most anterior and prominent in the jaw
MP:0005359	growth retardation of incisors	developmental delay of the growth of the incisors, the long pointed teeth, most anterior and prominent in the jaw
MP:0005360	urolithiasis	presence of calculi in any part of the urinary system
MP:0005361	small pituitary gland	reduced size of the pituitary gland, the compound gland suspended from the base of the hypothalamus
MP:0005362	abnormal Langerhans cell physiology	atypical or failure of normal function of the stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
MP:0005363	decreased susceptibility to prion infection	reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component
MP:0005364	increased susceptibility to prion infection	increased likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component
MP:0005365	abnormal bile salt homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of the steroid salts derived from cholesterol in the liver, produced as bile acids and secreted in the biliary system as bile salts; these play an important role in the digestion and absorption of fats
MP:0005366	variegated coat color	an irregular and random patchwork of two or more colors in the coat
MP:0005367	renal/urinary system phenotype	the observable morphological and physiological characteristics of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in a mammalian organism that are manifested through development and lifespan
MP:0005369	muscle phenotype	the observable morphological and physiological characteristics of the mammalian tissue composed of contractile cells or fibers that effects movement of an organ or part of the body that are manifested through development and lifespan
MP:0005370	liver/biliary system phenotype	the observable morphological and physiological characteristics of the  mammalian liver, gall bladder, or bile ducts that are manifested through development and lifespan
MP:0005371	limbs/digits/tail phenotype	the observable morphological and physiological characteristics of the subdivision of a mammalian organism that protrudes from the body that are manifested through development and lifespan
MP:0005375	adipose tissue phenotype	the observable morphological and physiological characteristics of mammalian fat tissue that are manifested through development and lifespan
MP:0005376	homeostasis/metabolism phenotype	the observable morphological and physiological characteristics related to a state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues or the processes that cause many of the chemical changes in living mammalian organisms that are manifested through development and lifespan
MP:0005377	hearing/vestibular/ear phenotype	the observable morphological and physiological characteristics of mammalian system responsible for the perception of spatial orientation and auditory stimuli that are manifested through development and lifespan
MP:0005378	growth/size/body region phenotype	the observable morphological and physiological characteristics related to the overall or change in physical magnitude or an anatomical structure which is a subpart of the whole organism manifested in a mammalian organism through development and lifespan
MP:0005379	endocrine/exocrine gland phenotype	the observable morphological and physiological characteristics of an organ that functions as a secretory or excretory organ in a mammalian organism that are manifested through development and lifespan
MP:0005380	embryo phenotype	the observable morphological and physiological characteristics of the manifested in a mammalian organism before birth, including embryonic and fetal stages and embryonic and extraembryonic tissues
MP:0005381	digestive/alimentary phenotype	the observable morphological and physiological characteristics of the mammalian system dedicated to the mechanical, chemical, and enzymatic processing of food that are manifested through development and lifespan
MP:0005382	craniofacial phenotype	the observable morphological and physiological characteristics of the face or head of a mammalian organism that are manifested through development and lifespan
MP:0005384	cellular phenotype	the observable morphological and physiological characteristics of the basic structural and functional unit of all mammalian organisms that are manifested through development and lifespan
MP:0005385	cardiovascular system phenotype	the observable morphological and physiological characteristics of the mammalian heart, blood vessels, or circulatory system that are manifested through development and lifespan
MP:0005386	behavior/neurological phenotype	the observable actions or reactions of mammalian organisms that are manifested through development and lifespan
MP:0005387	immune system phenotype	the observable morphological and physiological characteristics of the mammalian system that protects the body from foreign substances, cells, and tissues by producing the immune response and that includes especially the thymus, spleen, lymphoid tissue, lymphocytes including the B cells and T cells, and antibodies that are manifested through development and lifespan
MP:0005388	respiratory system phenotype	the observable morphological and physiological characteristics of the mammalian system responsible for the exchange of oxygen and carbon dioxide with the environment that are manifested through development and lifespan
MP:0005389	reproductive system phenotype	the observable morphological and physiological characteristics of the mammalian organs associated with producing offspring that are manifested through development and lifespan
MP:0005390	skeleton phenotype	the observable morphological and physiological characteristics of the bone, cartilage, teeth, tendons, ligaments and other associated tissues of the bony framework ot the body of a mammalian organism that are manifested through development and lifespan
MP:0005391	vision/eye phenotype	the observable morphological and physiological characteristics of the mammalian spheroid organ and optic nerve that serve to detect light that are manifested through development and lifespan
MP:0005394	taste/olfaction phenotype	the observable morphological and physiological characteristics of the organs involved in and perception of taste and smell in a mammalian organism that are manifested through development and lifespan
MP:0005395	obsolete other phenotype	
MP:0005397	hematopoietic system phenotype	the observable morphological and physiological characteristics of the mammalian blood cells or the organs associated with the development and formation of blood cells that are manifested through development and lifespan
MP:0005398	decreased susceptibility to fungal infection	reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms
MP:0005399	increased susceptibility to fungal infection	greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms
MP:0005400	abnormal vitamin level	any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function
MP:0005401	abnormal fat-soluble vitamin level	any anomaly in the concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function and which require the presence of lipids for assimilation in the body
MP:0005402	abnormal action potential	change in the electric response of a nerve or other excitable tissue to its stimulation
MP:0005403	abnormal nerve conduction	anomaly in the act of transmitting electricity along a single nerve
MP:0005404	abnormal axon morphology	any structural anomaly of the single process of a nerve cell that normally conducts impulses away from the cell body
MP:0005405	axon degeneration	retrogressive pathologic change in the single process of a nerve cell
MP:0005406	abnormal heart size	change from normal in the physical magnitude of the cardiac muscle or any of its component structures
MP:0005407	hyperalgesia	increased sensitivity to painful stimuli; can be due to inflammatory response or due to damage to soft tissue containing nociceptors or injury to a peripheral nerve; it can be primary (at the site of the injury) or secondary (in the surrounding undamaged area)
MP:0005408	hypopigmentation	dilution of pigment in any or all tissues or a part of a tissue
MP:0005409	darkened coat color	amount and distribution of yellow pigment (phaeomelanin) relative to black or brown pigment (eumelanin) is decreased when compared to wild-type agouti
MP:0005410	abnormal fertilization	anomaly in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei
MP:0005411	delayed fertilization	a lag in the normal time of onset of the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei
MP:0005412	vascular stenosis	abnormal narrowing or constriction of the lumen of one or more blood vessels
MP:0005413	vascular restenosis	recurrence of a narrowing or constriction of a blood vessel following surgical or mechanical removal or reduction of a previous narrowing
MP:0005414	extrahepatic cholestasis	impairment of bile flow in the large bile ducts by mechanical obstruction or stricture due to benign or malignant process
MP:0005415	intrahepatic cholestasis	impairment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts
MP:0005416	abnormal circulating protein level	anomaly in the amount in the blood of any of the macromolecules consisting of long chains of amino acids in peptide linkage
MP:0005418	abnormal circulating hormone level	any anomaly in the blood concentration of any of the chemical substances that have specific regulatory effects on the activity of a certain organ or organs; originally applied to substances secreted by various endocrine glands and transported in the bloodstream to the target organs, it is sometimes extended to include substances that are not produced by the endocrine glands but that have similar effects
MP:0005419	decreased circulating serum albumin level	blood serum albumin concentration below the normal range
MP:0005421	loose skin	condition in which the skin hangs in folds
MP:0005422	osteosclerosis	abnormal hardening or eburnation (change in exposed subchondral bone in degenerative joint disease in which bone is converted into a dense substance with a smooth surface) of bone
MP:0005423	abnormal somatic nervous system physiology	any functional anomaly of the part of the peripheral nervous system that is responsible for conveying voluntary motor and external sensory information, including all nerves controlling the skeletal muscular system and external sensory receptors (including balance, smell, sight, taste, touch and hearing sensory inputs)
MP:0005424	jerky movement	continuous, abrupt, faltering motions of the whole body or a portion of the body
MP:0005425	increased macrophage cell number	greater than the normal numbers of macrophages
MP:0005426	tachypnea	rapid breathing
MP:0005428	obsolete abnormal clinical chemistry	OBSOLETE. any anomaly in the laboratory tests that show the presence of physiologically significant substances in the blood, urine, tissue, and body fluids with application to the diagnosis or therapy of disease
MP:0005429	obsolete abnormal pine bedding color after urinary excretion	OBSOLETE. with normal urine coloration, a change in the hue of the pine bedding of a mouse, often to a bright yellow or chartreuse, after excretion of urine by the animal housed with this type of bedding; indicative of a metabolic defect
MP:0005430	absent fibula	absence of the lateral and shorter of the two bones of the lower leg
MP:0005431	decreased oocyte number	reduced numbers of germ cells in the female
MP:0005432	abnormal pro-B cell morphology	any structural anomaly of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
MP:0005433	absent early pro-B cells	absence of cells in the B lymphocyte lineage that undergo D-J rearrangement of the immunoglobulin heavy chain
MP:0005434	absent late pro-B cells	absence of the cells in the B lymphocyte lineage that undergo V-DJ rearrangement of the immunoglobulin heavy chain
MP:0005435	hemoperitoneum	blood in the peritoneal cavity
MP:0005437	abnormal glycogen level	any anomaly in the concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle
MP:0005438	abnormal glycogen homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of glycogen, a readily converted carbohydrate reserve found in most tissues of the body, especially liver and muscle
MP:0005439	decreased glycogen level	less than the normal concentration of a readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle
MP:0005440	increased glycogen level	greater than the normal concentration of this readily converted carbohydrate reserve, found in most tissues of the body, especially liver and muscle
MP:0005441	increased urine calcium level	abnormally large amounts of calcium in the urine
MP:0005442	obsolete abnormal pyramidal neuron morphology	OBSOLETE. any structural anomaly of the projection neurons in the cerebral cortex and hippocampus
MP:0005443	abnormal ethanol metabolism	altered ability to metabolize the clear, colorless liquid that has formula C2H6O
MP:0005444	abnormal retinol metabolism	altered ability to metabolize retinol, which plays an essential role in metabolic functioning of the retina, and growth of and differentiation
MP:0005445	abnormal neurotransmitter secretion	anomaly in the production or release of endogenous signaling molecules into a synaptic cleft; neurotransmitters are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell
MP:0005446	abnormal synaptic epinephrine release	aberrant secretion across synapses of the active sympathomimetic hormone that stimulates both the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0005447	abnormal synaptic norepinephrine release	aberrant secretion across synapses of this widespread central and autonomic neurotransmitter, the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus
MP:0005448	abnormal energy homeostasis	any anomaly in the process involved in the balance between food intake (energy input) and energy expenditure
MP:0005449	abnormal food intake	any anomaly in the total number of calories/food amount taken in over time when compared to the normal state
MP:0005450	abnormal energy expenditure	utilization of calories that differs from normal
MP:0005451	abnormal body composition	aberrant relative amount and distribution of bone, body fat, muscle or lean tissue mass
MP:0005452	abnormal adipose tissue amount	more or less than the normal total amount of connective tissue composed of fat cells
MP:0005455	increased susceptibility to weight gain	greater increase in body weight over time when compared to the average increase in weight on the same diet, with equal energy (calorie) intake
MP:0005456	obsolete weight gain	OBSOLETE. increase in weight over existing weight
MP:0005457	abnormal percent body fat/body weight	more or less fat, relative to controls, expressed as a percentage of total body weight
MP:0005458	increased percent body fat/body weight	more fat, relative to controls, expressed as a percentage of total body weight
MP:0005459	decreased percent body fat/body weight	less fat, relative to controls, expressed as a percentage of total body weight
MP:0005460	abnormal leukopoiesis	any anomaly in the process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells
MP:0005461	abnormal dendritic cell morphology	any structural anomaly of a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation
MP:0005462	abnormal mast cell differentiation	atypical production of or inability to produce a cell that is found in almost all tissues, containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation
MP:0005463	abnormal CD4-positive, alpha-beta T cell physiology	any functional anomaly of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0005464	abnormal platelet physiology	any functional anomaly of the non-nucleated cells found in the blood and involved in blood coagulation
MP:0005465	abnormal T-helper 1 physiology	abnormal function of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0005466	abnormal T-helper 2 physiology	abnormal function of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0005467	obsolete abnormal chemotactic leukotriene physiology	OBSOLETE. functional anomaly of any of a subset of leukotrienes that are involved in attracting leukocytes to a site of tissue injury
MP:0005468	abnormal thyroid hormone level	aberrant concentration of any of the hormones secreted by the thyroid gland
MP:0005469	abnormal thyroxine level	any anomaly in the concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism
MP:0005470	increased thyroxine level	greater than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism
MP:0005471	decreased thyroxine level	less than the normal concentration of the major hormone derived from the thyroid gland; it normally affects cellular metabolism
MP:0005472	abnormal triiodothyronine level	anomaly in the amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005473	decreased triiodothyronine level	reduced amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005474	increased triiodothyronine level	greater amount of a thyroid hormone that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005475	abnormal circulating thyroxine level	anomaly in the blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism
MP:0005476	abnormal circulating triiodothyronine level	anomaly in the amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005477	increased circulating thyroxine level	greater than the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism
MP:0005478	decreased circulating thyroxine level	reduction in the normal blood concentration of the major hormone derived from the thyroid gland that normally affects cellular metabolism
MP:0005479	decreased circulating triiodothyronine level	reduced amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005480	increased circulating triiodothyronine level	greater amount of a thyroid hormone present in the blood that regulates growth and development, controls some metabolic processes and body temperature, and negatively regulates secretion of thyrotropin by the pituitary gland
MP:0005481	increased chronic myelocytic leukemia incidence	higher than normal incidence of a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages
MP:0005482	obsolete cellular hypertrophy	OBSOLETE. increased size or bulk of a cell, without accompanying increased numbers
MP:0005483	obsolete cellular hyperplasia	OBSOLETE. an increase in the number of cells in an organ or tissue
MP:0005485	obsolete cellular dysplasia	OBSOLETE. change in the size, shape, and organization of the cellular components of a tissue
MP:0005486	obsolete cellular metaplasia	OBSOLETE. conversion of one differentiated cell type to another
MP:0005487	obsolete cellular hypoplasia	OBSOLETE. a decrease in the number of cells in an organ or tissue
MP:0005488	bronchial epithelial hyperplasia	increase in the number of normal cells in normal arrangement in the bronchial epithelium, typically resulting in increased size
MP:0005489	vascular smooth muscle hyperplasia	increase in the number of normal cells in normal arrangement in the vascular smooth muscle, typically resulting in increased size
MP:0005490	increased club cell number	increased numbers of the rounded, club-shaped, nonciliated cells found between ciliated cells in bronchiolar epithelium
MP:0005491	pancreatic islet hyperplasia	increase in the number of normal cells in normal arrangement in the pancreatic islets, typically resulting in increased size
MP:0005492	exocrine pancreas hypoplasia	decrease in the number of normal cells in normal arrangement in the exocrine pancreas, typically resulting in decreased size
MP:0005493	stomach epithelial hyperplasia	increase in the number of normal cells in normal arrangement in the stomach epithelium, typically resulting in increased size
MP:0005494	esophagogastric junction metaplasia	conversion of one differentiated cell type to another differentiated cell type at the terminal end of the esophagus and beginning of the stomach
MP:0005497	optic nerve cupping	concave shape of the nerve often as a result of the force of pressure from glaucoma
MP:0005498	hyporesponsive to tactile stimuli	reduced reflex action normally induced by touch or pain
MP:0005499	abnormal olfactory system morphology	any structural anomaly of the organs involved in smell
MP:0005500	abnormal gustatory system morphology	any structural anomaly of the organs involved in taste
MP:0005501	abnormal skin physiology	any functional anomaly of the membranous protective covering of the body
MP:0005502	abnormal renal/urinary system physiology	any functional anomaly of any of the organs or tissues responsible for fluid volume regulation, regulating electrolytes, maintaining acid-base homeostasis, and elimination of water and water soluble waste products in an organism
MP:0005503	abnormal tendon morphology	any structural anomaly of the fibrous bands or cords of connective tissue at the ends of muscle fibers that attach muscles to bones and other structures
MP:0005504	abnormal ligament morphology	any structural anomaly of the flexible bands of fibrous tissue that connect the articular extremities of bones
MP:0005505	thrombocytosis	greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation
MP:0005506	obsolete abnormal limbs/digits/tail physiology	OBSOLETE. functional anomaly of the digits, paws, limbs, or tail
MP:0005507	tail dragging	pulling the tail along with difficulty or effort; may be due to paralysis or weakness
MP:0005508	abnormal skeleton morphology	any structural anomaly of the bony framework of the body in vertebrates
MP:0005515	uveitis	inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina)
MP:0005516	enhanced liver regeneration	increase in the renewal, repair, and/or regrowth of liver tissue following injury or disease
MP:0005517	impaired liver regeneration	decrease in the renewal, repair, and/or regrowth of liver tissue following injury or disease
MP:0005518	abnormal pancreas regeneration	anomaly in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease
MP:0005519	enhanced pancreas regeneration	increase in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease
MP:0005520	impaired pancreas regeneration	decrease in the renewal, repair, and/or regrowth of pancreatic tissue following injury or disease
MP:0005521	abnormal circulating atrial natriuretic factor level	deviation from the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator
MP:0005522	increased circulating atrial natriuretic factor	greater than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator
MP:0005523	decreased circulating atrial natriuretic factor	less than the normal concentration of the peptide hormone in the blood that regulates the water-electrolyte balance and acts as a vasodilator
MP:0005524	abnormal renal plasma flow rate	deviation from the normal volume of plasma passing through the kidney per unit time
MP:0005525	increased renal plasma flow rate	greater than the normal volume of plasma passing through the kidney per unit time
MP:0005526	decreased renal plasma flow rate	less than the normal volume of plasma passing through the kidney per unit time
MP:0005527	increased renal glomerular filtration rate	greater than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time
MP:0005528	decreased renal glomerular filtration rate	less than the normal volume of water filtered out of the plasma through glomerular capillary walls into the Bowman's capsule per unit time
MP:0005529	abnormal renal vascular resistance	deviation from the normal force opposing blood flow in the kidney blood vessels
MP:0005530	decreased renal vascular resistance	less than the normal force opposing blood flow in the kidney blood vessels
MP:0005531	increased renal vascular resistance	greater than the normal force opposing blood flow in the kidney blood vessels
MP:0005532	abnormal vascular resistance	deviation from the normal force opposing the flow of blood through a vascular bed; it is equal to the difference in blood pressure across the vascular bed divided by the cardiac output
MP:0005533	increased body temperature	greater than the level of heat natural to a living being
MP:0005534	decreased body temperature	less than the level of heat natural to a living being
MP:0005535	abnormal body temperature	deviation in the level of heat natural to a living being
MP:0005536	decreased Leydig cell number	decreased number of the interstitial cells found adjacent to the seminiferous tubules in the testicle that produce testosterone in the presence of luteinizing hormone
MP:0005537	abnormal cerebral aqueduct morphology	any structural anomaly of the channel in the mesencephalon that connects the third and fourth ventricles
MP:0005540	decreased urine albumin level	less than the normal amount of albumin in the urine
MP:0005541	abnormal iris stromal pigmentation	any anomaly in the coloring of the framework of the iris
MP:0005542	cornea vascularization	formation of blood vessels in the cornea, which normally lacks vessels
MP:0005543	decreased cornea thickness	decreased thickness of the cornea, the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure
MP:0005544	cornea deposits	accumulation of minerals, proteins, or other anomalous substances on the cornea
MP:0005545	abnormal lens development	aberrant formation of the transparent structure of the eye responsible for focusing light rays
MP:0005546	choroidal neovascularization	new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera
MP:0005547	abnormal Muller cell morphology	any structural anomaly of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements
MP:0005548	retina pigment epithelium atrophy	acquired diminution of the size of the epithelial layer of the retina composed of cells containing pigment granules, associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0005549	retina pigment epithelium hyperplasia	increase in the number of normal cells in normal arrangement in the retinal pigment epithelium, typically resulting in increased size
MP:0005550	obsolete orbital hemorrhage	OBSOLETE. escape of blood into the orbit
MP:0005551	abnormal eye electrophysiology	any functional anomaly of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)
MP:0005552	obsolete abnormal orbital bone morphology	OBSOLETE. structural anomaly of the bony cavity that contains the eyeball and is formed by parts of eight bones in the mouse: maxilla, lacrimal, zygomatic, frontal, temporal, sphenoid, ethmoid, palatine
MP:0005553	increased circulating creatinine level	greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction
MP:0005554	decreased circulating creatinine level	less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction
MP:0005556	abnormal renal filtration rate	altered ability of the kidneys to remove substances from the plasma for excretion in a specific period of time
MP:0005557	increased creatinine clearance	increased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded
MP:0005558	decreased creatinine clearance	decreased rate of the process in which creatine is removed from the blood via renal filtration and its constituent parts degraded
MP:0005559	increased circulating glucose level	greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source
MP:0005560	decreased circulating glucose level	less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source
MP:0005561	increased mean corpuscular hemoglobin	greater than the average levels of hemoglobin contained in an erythrocyte
MP:0005562	decreased mean corpuscular hemoglobin	less than the average levels of hemoglobin contained in an erythrocyte
MP:0005563	abnormal hemoglobin content	deviation from the normal total hemoglobin content in the circulating blood
MP:0005564	increased hemoglobin content	increase in the total hemoglobin content in the circulating blood
MP:0005565	increased blood urea nitrogen level	high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function
MP:0005566	decreased blood urea nitrogen level	low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function
MP:0005567	decreased circulating total protein level	total circulating protein level below the normal range
MP:0005568	increased circulating total protein level	total circulating protein level above the normal range
MP:0005571	decreased lactate dehydrogenase level	reduced level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate
MP:0005572	abnormal pulmonary respiratory rate	deviation from the normal number of breaths per minute
MP:0005573	increased pulmonary respiratory rate	greater than the normal number of breaths per minute
MP:0005574	decreased pulmonary respiratory rate	fewer than the normal number of breaths per minute
MP:0005575	increased pulmonary ventilation	increase in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment
MP:0005576	decreased pulmonary ventilation	reduction in the respiratory minute volume, or the total volume of gas per minute inspired or expired expressed in liters per minute; refers to the exchange of air between the total respiratory space and the environment
MP:0005577	uterus prolapse	downward movement, and possible external appearance, of the uterus through the vagina
MP:0005578	teratozoospermia	presence of structurally anomalous spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends
MP:0005579	absent outer ear	absence of the auricles or external acoustic meatus
MP:0005580	periinsulitis	an accumulation of macrophages, dendritic cells, and B and T lymphocytes in the periductal areas of the pancreas but outside the islet cell areas; often occurs prior to intra-insulitis of the islet cell areas
MP:0005581	abnormal renin activity	altered ability of this enzyme to cleave angiotensionogen and create angiotensin I
MP:0005582	increased renin activity	greater than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I
MP:0005583	decreased renin activity	less than the normal ability of this enzyme to cleave angiotensionogen and create angiotensin I
MP:0005584	abnormal enzyme/coenzyme activity	altered ability of any enzyme or their cofactors, to act as catalysts to induce chemical changes in other substances
MP:0005585	increased tidal volume	greater than the normal volume of air inspired or expired during each normal respiratory cycle
MP:0005586	decreased tidal volume	less than the normal volume of air inspired or expired during each normal respiratory cycle
MP:0005587	abnormal Meckel's cartilage morphology	any structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments
MP:0005590	increased vasodilation	greater than the expected or normal widening of the lumen of the blood vessels
MP:0005591	decreased vasodilation	less than the expected or normal widening of the lumen of the blood vessels
MP:0005592	abnormal vascular smooth muscle morphology	any structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels
MP:0005595	abnormal vascular smooth muscle physiology	any functional anomaly of the nonstriated, involuntary muscle tissue of the blood vessels
MP:0005596	increased susceptibility to type I hypersensitivity reaction	greater likelihood of developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks
MP:0005597	decreased susceptibility to type I hypersensitivity reaction	less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks
MP:0005598	decreased heart ventricle muscle contractility	reduced ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume
MP:0005599	increased cardiac muscle contractility	greater than the normal ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max, fractional shortening (FS), velocity of circumferential fiber shortening (Vcfc), peak of aortic outflow velocity (PAV), and ventricular ejection fraction volume
MP:0005600	increased heart ventricle muscle contractility	greater than the normal ability of the heart ventricle muscle to shorten or to develop increased tension, often measured by ventricular ejection fraction volume
MP:0005601	increased angiogenesis	enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network
MP:0005602	decreased angiogenesis	reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network
MP:0005603	neuron hypertrophy	increased size of any of the structural and functional units of the nervous system, which consist of the nerve cell body, the dendrites, and the axon
MP:0005604	hyperekplexia	disorder characterized by pathologic startle responses, protective reactions to unanticipated, potentially threatening, stimuli of any type, particularly auditory
MP:0005605	increased bone mass	an increase in the total amount of bone tissue contained in the skeleton
MP:0005606	increased bleeding time	greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function
MP:0005607	decreased bleeding time	less than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function
MP:0005608	cardiac interstitial fibrosis	formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process
MP:0005609	abnormal circulating antidiuretic hormone level	deviation from the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle
MP:0005610	increased circulating antidiuretic hormone level	greater than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle
MP:0005611	decreased circulating antidiuretic hormone level	less than the normal concentration of the peptide hormone in the blood that is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle
MP:0005612	decreased susceptibility to type II hypersensitivity reaction	less likelihood of or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved
MP:0005613	increased susceptibility to type II hypersensitivity reaction	greater likelihood or resistance to developing a response caused by an Ag-Ab reaction; antibodies are directly or indirectly cytotoxic to antigens on cell surfaces or in connective tissues; most often involves IgG and IgM; complement activation is usually involved
MP:0005614	decreased susceptibility to type III hypersensitivity reaction	less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
MP:0005615	increased susceptibility to type III hypersensitivity reaction	greater likelihood of developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via antibodies encountering circulating antigen; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury
MP:0005616	decreased susceptibility to type IV hypersensitivity reaction	less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact
MP:0005617	increased susceptibility to type IV hypersensitivity reaction	greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact
MP:0005618	decreased urine potassium level	less than the normal amount of potassium in the urine
MP:0005619	increased urine potassium level	greater than normal amount of potassium in the urine
MP:0005620	abnormal muscle contractility	aberrant ability of a muscle to shorten or to develop increased tension
MP:0005621	abnormal cell physiology	any functional anomaly of the vital processes of the cell
MP:0005623	abnormal meninges morphology	any structural anomaly in any of the membranes covering the spinal cord and brain, including the dura mater (external), arachnoid (middle), and pia mater (internal)
MP:0005624	abnormal plasma anion gap	measurement of the interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate
MP:0005625	increased plasma anion gap	greater than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; high anion gap is indicative of metabolic acidosis
MP:0005626	decreased plasma anion gap	less than the normal interval between the sum of routinely measured cations minus the sum of the routinely measured anions in the blood; the anion gap = (Na+ + K+) - (Cl- + HCO3-) where Na- is sodium, K+ is potassium, Cl- is chloride, and HCO3- is bicarbonate; low anion gap is relatively rare but may occur from the presence of abnormal positively charged proteins, as in multiple myeloma
MP:0005627	increased circulating potassium level	greater than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle
MP:0005628	decreased circulating potassium level	less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle
MP:0005629	abnormal lung weight	anomaly in the average weight of the lung
MP:0005630	increased lung weight	greater than average weight of the lung
MP:0005631	decreased lung weight	reduced average weight of the lung
MP:0005632	decreased circulating aspartate transaminase level	less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction
MP:0005633	increased circulating sodium level	greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume
MP:0005634	decreased circulating sodium level	less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume
MP:0005635	decreased circulating bilirubin level	reduced concentration in the blood of the bile pigment bilirubin, normally found in the liver and in red blood cells
MP:0005636	abnormal mineral homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of inorganic substances that have importance in body functions
MP:0005637	abnormal iron homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of iron that normally is a cofactor in the heme of hemoglobin, myoglobin, transferrin, ferritin, and iron-containing porphyrins; it is an essential component of enzymes such as catalase, peroxidase, and various cytochromes
MP:0005638	hemochromatosis	disorder due to the deposition of hemosiderin in the parenchymal cells, causing tissue damage and dysfunction of the liver, pancreas, heart, and pituitary
MP:0005639	hemosiderosis	condition in which there is a generalized increase in the iron stores of body tissues, particularly of liver and the reticuloendothelial system, without demonstrable tissue damage
MP:0005640	abnormal mean corpuscular hemoglobin concentration	deviation from the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices
MP:0005641	increased mean corpuscular hemoglobin concentration	greater than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices
MP:0005642	decreased mean corpuscular hemoglobin concentration	less than the normal Hgb/Hct; the average hemoglobin concentration in a given volume of packed red cells, calculated from the hemoglobin therein and the hematocrit, in erythrocyte indices
MP:0005643	decreased dopamine level	less than the normal amount of this catecholamine neurotransmitter and neurohormone, derived from tyrosine and the precursor to norepinephrine and epinephrine; functions as a neurotransmitter in the brain and as a hormone to inhibit the release of prolactin from the anterior lobe of the pituitary
MP:0005644	agonadal	denoting the absence of gonads
MP:0005645	abnormal hypothalamus physiology	any functional anomaly of the ventral and medial region of the diencephalon forming the walls of the ventral half of the third ventricle, which is normally involved in the functions of the autonomic (visceral motor) nervous system and, through its vascular link with the anterior lobe of the pituitary gland, in endocrine mechanisms
MP:0005646	abnormal pituitary gland physiology	any functional anomaly of this unpaired compound gland suspended from the base of the hypothalamus by a short extension of the infundibulum, the infundibular or pituitary stalk
MP:0005647	abnormal sex gland physiology	any functional anomaly of any of the organized aggregations of cells that function as secretory or excretory organs and are associated with reproduction
MP:0005648	heart right ventricle degeneration	replacement of cardiomyocytes in the right ventricle with fibrous tissue and/or fat
MP:0005649	increased spleen neoplasm incidence	greater than the expected number of a neoplasm of the spleen, occurring in a specific population in a given time period
MP:0005650	abnormal limb bud morphology	any structural anomaly of the mesenchymal outgrowth on the lateral trunk of the embryo that develops into the limbs
MP:0005651	abnormal gonad rudiment morphology	any structural anomaly of the undifferentiated mesoderm that gives rise to the gonads
MP:0005652	sex reversal	development of the reproductive system is inconsistent with the chromosomal sex
MP:0005653	phototoxicity	condition caused by overexposure to UV light or from the combination of exposure to specific wavelengths and a phototoxic substance
MP:0005654	porphyria	acquired or inherited group of disorders characterized by excessive production of porphyrins or their precursors; if acquired, it results from inhibition of enzymes in the heme metabolic pathway by drugs, toxins or abnormal metabolites
MP:0005655	increased aggression	when compared to controls, subjects exhibit greater than the normal level of domineering, assault posture and/or hostile physical action
MP:0005656	decreased aggression	when compared to controls, subjects exhibit less than the normal level of domineering, assault posture and/or hostile physical action
MP:0005657	abnormal neural plate morphology	any structural anomaly of the flat, thickened layer of ectodermal cells in the neuroectodermal area of the embryo's dorsal surface that develops into the neural tube and neural crest
MP:0005658	increased susceptibility to diet-induced obesity	more likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat
MP:0005659	decreased susceptibility to diet-induced obesity	less likely to become excessively overweight or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat
MP:0005660	abnormal circulating adrenaline level	aberrant concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0005661	decreased circulating adrenaline level	less than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0005662	increased circulating adrenaline level	greater than the normal concentration in the blood of a catecholamine hormone that stimulates the adrenergic receptors and that causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels
MP:0005663	abnormal circulating noradrenaline level	aberrant blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine
MP:0005664	decreased circulating noradrenaline level	less than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine
MP:0005665	increased circulating noradrenaline level	greater than the normal blood amount of the hormone secreted by the adrenal medulla and acts as a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS; noradrenaline is the demethylated biosynthetic precursor of epinephrine
MP:0005666	abnormal adipose tissue physiology	any functional anomaly of the connective tissue composed of fat cells enmeshed in areolar tissue
MP:0005667	abnormal circulating leptin level	anomaly in the blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance
MP:0005668	decreased circulating leptin level	less than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance
MP:0005669	increased circulating leptin level	greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance
MP:0005670	abnormal white adipose tissue physiology	any functional anomaly in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels
MP:0005671	abnormal response to transplant	anomaly in the body's reaction to the grafting of organs, tissues, or cells taken from the same individual for another area of the body or from another individual
MP:0005672	increased susceptibility to graft versus host disease	greater likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host
MP:0005673	decreased susceptibility to graft versus host disease	less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host
MP:0005675	small gallbladder	reduced size of the gall bladder, the organ that serves as a storage reservoir for bile
MP:0006000	abnormal cornea epithelium morphology	any structural anomaly of the smooth stratified squamous epithelium that covers the outer surface of the cornea
MP:0006001	abnormal intestinal transit time	increase or decrease in the time it takes for a bolus of material to pass through the intestine
MP:0006002	abnormal small intestinal transit time	increase or decrease in the time it takes for a bolus of material to pass through the small intestine
MP:0006003	abnormal large intestinal transit time	increase or decrease in the time it takes for a bolus of material to pass through the large intestine
MP:0006004	obsolete abnormal interneuron morphology	OBSOLETE. any structural anomaly of neurons that exclusively interact with other neurons
MP:0006005	obsolete decreased interneuron number	OBSOLETE. fewer than normal number of neurons that interact only with other neurons
MP:0006006	increased sensory neuron number	greater than normal numbers of cells that innervate an effector (muscle or glandular) tissue and are responsible for transmission of sensory impulses
MP:0006007	abnormal basal ganglion morphology	any structural anomaly of any of a group of nuclei associated with the ability to carry out willed movements, including the caudate, putamen, nucleus accumbens, globus pallidus, substantia nigra, and subthalamic nucleus
MP:0006009	abnormal neuronal migration	any anomaly in the movement of immature neurons from germinal zones to specific positions where they will reside as they mature
MP:0006010	absent strial intermediate cells	absence of the melanocytes (i.e. crest-derived intermediate cells) normally located within the intrastrial space; loss of strial intermediate cells is known to lead to loss of the endocochlear potential
MP:0006011	abnormal endolymphatic duct morphology	any structural anomaly of the small membranous canal, connecting with both saccule and utricle of the membranous labyrinth, passing through the aqueduct of vestibule, and terminating in the endolymphatic sac
MP:0006012	dilated endolymphatic duct	stretched or widened aperture of the luminal space of the endolymphatic duct
MP:0006013	absent endolymphatic sac	absence of the dilated blind extremity of the endolymphatic duct, which lies external to the dura on the posterior aspect of the petrous part of the temporal bone
MP:0006014	dilated endolymphatic sac	stretched or widened aperture of the luminal space of the endolymphatic sac
MP:0006015	dilated lateral semicircular canal	stretched or widened aperture of the luminal space of the lateral semicircular canal
MP:0006016	dilated posterior semicircular canal	stretched or widened aperture of the luminal space of the posterior semicircular canal
MP:0006017	dilated superior semicircular canal	stretched or widened aperture of the luminal space of one or both of the superior semicircular canals
MP:0006018	abnormal tympanic membrane morphology	any structural anomaly of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear
MP:0006019	absent tympanic membrane	absence of the thin, tense membrane forming the greater part of the lateral wall of the tympanic cavity and separating it from the external acoustic meatus; the tympanic membrane constitutes the boundary between the external and middle ear
MP:0006020	decreased tympanic ring size	smaller than average tympanic ring
MP:0006021	abnormal Reissner membrane morphology	any structural anomaly of the membrane which separates the cochlear duct from the vestibular canal, i.e. the endolymph of the scala media from the perilymph of the scala vestibuli; the Reissner membrane consists of squamous epithelial cells with microvilli toward the ductus, a basement membrane, and a thin layer of connective tissue toward the scala
MP:0006022	absent Reissner membrane	loss of the membrane which separates the cochlear duct from the vestibular canal
MP:0006023	detached Reissner membrane	partial or complete loss of connection between the membrane and the stria vascularis, the periosteum covering the lamina spiralis ossea, or both
MP:0006024	collapsed Reissner membrane	the Reissner's membrane, which normally separates the scala media from the scala vestibuli, has collapsed onto the spiral limbus and the tectorial membrane of the organ of Corti
MP:0006025	distended Reissner membrane	an increase in the volume of endolymphatic fluid that results in distortion of the vestibular membrane
MP:0006026	dilated terminal bronchiole tube	stretched or widened aperture of the luminal space of one or more of the terminal bronchiole tubes
MP:0006027	impaired lung alveolus development	a block or reduction in the formation of the sacs for holding air in the lungs, which are formed by the terminal dilation of air passageways
MP:0006028	obsolete impaired bronchiole branching	OBSOLETE. a block or reduction in the morphogenesis of the bronchioles
MP:0006029	abnormal sclerotome morphology	any structural anomaly of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord; normally, sclerotomal cells from adjacent somites become merged in intersomitically located masses that are the primordia of the centra of the vertebrae
MP:0006030	abnormal otic vesicle development	anomaly in the formation of the simple epithelial sac formed from the otic placode that gives rise to the structures of the inner ear
MP:0006031	abnormal pharyngeal pouch morphology	any structural anomaly of the balloonlike diverticulae of the embryonic pharyngeal endoderm that line the inside of the branchial arches; these paired endodermal evaginations develop in a craniocaudal sequence between the branchial arches, e.g. pouch 1 lies between arches 1 and 2; in mammals, there are four well-developed pairs of pouches (the fifth and sixth pair is vestigial or absent); the pouch endoderm reaches the branchial groove ectoderm to form the double-layer branchial membranes that separate them
MP:0006032	abnormal ureteric bud morphology	any structural anomaly of the epithelial swelling on the metanephric duct that elongates to invade the adjacent metanephric mesenchyme; interactions between the ureteric bud and the metanephric mesenchyme leads to the initiation of outgrowth and repetitive branching of the UB that ultimately generates the definitive renal collecting system and induces formation of renal vesicles from the mesenchyme tissue
MP:0006033	abnormal external auditory canal morphology	any structural anomaly of the canal that connects the outer and middle ear
MP:0006034	myoglobinuria	presence of myoglobin in the urine
MP:0006035	abnormal mitochondrial morphology	any structural anomaly of the semiautonomous, self replicating organelles that occur in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells; mitochondria are notably the site of tissue respiration
MP:0006036	abnormal mitochondrial physiology	any functional anomaly of the cellular organelles responsible for energy production
MP:0006037	abnormal mitochondrial fission	anomaly in the expansion rate of the cellular organelles responsible for energy production by division
MP:0006038	increased mitochondrial fission	increase in the expansion rate of the cellular organelles responsible for energy production by division
MP:0006039	decreased mitochondrial fission	reduction in the expansion rate of the cellular organelles responsible for energy production by division
MP:0006040	obsolete increased mitochondrial oxidation	OBSOLETE. greater than normal activity of the process in mitochondria that produces ATP
MP:0006041	obsolete decreased mitochondrial oxidation	OBSOLETE. less than normal activity of the mitochondrial process that produces ATP
MP:0006042	increased apoptosis	greater than normal programmed cell death
MP:0006043	decreased apoptosis	less than normal cell death
MP:0006044	tricuspid valve regurgitation	the backward reflux of blood through the tricuspid valve, due to insufficiency caused by disease, aging or congenital malformation
MP:0006045	mitral valve regurgitation	the backward reflux of blood through the mitral valve, due to insufficiency caused by disease, aging or congenital malformation
MP:0006046	atrioventricular valve regurgitation	the backward reflux of blood through the atrioventricular valve, due to insufficiency caused by disease, aging or congenital malformation
MP:0006047	aortic valve regurgitation	the backward reflux of blood through the aortic valve, due to insufficiency caused by disease, aging or congenital malformation
MP:0006048	pulmonary valve regurgitation	the backward reflux of blood through the pulmonary valve, due to insufficiency caused by disease, aging or congenital malformation
MP:0006049	semilunar valve regurgitation	the backward reflux of blood through the semilunar valve(s), due to insufficiency caused by disease, aging or congenital malformation
MP:0006050	pulmonary fibrosis	formation of fibrous tissue within the lung often resulting from inflammation or injury
MP:0006051	brainstem hemorrhage	bleeding into the brain stem
MP:0006052	cerebellum hemorrhage	bleeding into the cerebellum
MP:0006053	hypothalamus hemorrhage	bleeding into the hypothalamus
MP:0006054	spinal hemorrhage	bleeding into the spine
MP:0006055	abnormal vascular endothelial cell morphology	any structural anomaly of the cells that line the vasculature
MP:0006056	increased vascular endothelial cell number	greater than normal number of cells lining the vasculature
MP:0006057	decreased vascular endothelial cell number	less than normal number of cells lining the vasculature
MP:0006058	decreased cerebral infarct size	decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply
MP:0006059	decreased susceptibility to ischemic brain injury	less severe response, such as decreased incidence and/or size of necrotic tissue, to lack of adequate blood flow resulting from trauma or disease, to support the normal functioning of all or part of the brain compared to controls
MP:0006060	increased cerebral infarct size	increased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply
MP:0006061	right atrial isomerism	anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the right side of the body
MP:0006062	abnormal vena cava morphology	any structural anomaly of either of the two largest veins in the body
MP:0006063	abnormal inferior vena cava morphology	any structural anomaly of the principal vein draining blood from the lower portion of the body
MP:0006064	abnormal superior vena cava morphology	any structural anomaly of the principal vein draining blood from the upper portion of the body and delivering it to the right ventricle of the heart
MP:0006065	abnormal heart position or orientation	the heart is displaced from the normal left-sided position and/or orientation
MP:0006066	decreased clearance of atrial thrombosis	slower removal of a thrombus from the atria of the heart
MP:0006067	increased clearance of atrial thrombosis	faster removal of a thrombus from the atria of the heart
MP:0006068	abnormal retina horizontal cell morphology	any structural anomaly of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina
MP:0006069	abnormal retina neuronal layer morphology	any structural anomaly of any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments
MP:0006070	increased retina photoreceptor cell number	greater than the expected number of rods and/or cones
MP:0006071	abnormal retina progenitor cell morphology	any structural anomaly of the cells that give rise to the various cells of the retina
MP:0006072	abnormal retina apoptosis	change in the timing or the number of cells in the retina undergoing programmed cell death
MP:0006073	abnormal retina bipolar cell morphology	any structural anomaly of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells
MP:0006074	abnormal retina rod bipolar cell morphology	any structural anomaly of the bipolar cells that function in low light and transmit signals only through amacrine cells
MP:0006075	abnormal retina cone bipolar cell morphology	any structural anomaly of the retinal bipolar cells that connect to both ganglion and amacrine cells
MP:0006076	abnormal circulating homocysteine level	aberrant amount in the blood of sulfur-containing alpha-amino acid found in the plasma; blood levels are regulated by folic acid, vitamin B6 and vitamin B12
MP:0006077	inguinal hernia	hernia through the abdominal wall in the region of the groin known as Hesselbach's triangle
MP:0006078	abnormal nipple morphology	any structural anomaly of the erectile projection at the apex of the mammary gland where the lactiferous ducts open
MP:0006080	brain ischemia	inadequate blood flow to a region of the brain that may lead to cerebral infarction
MP:0006082	CNS inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord
MP:0006083	abnormal blood vessel elastic tissue morphology	any structural anomaly of the elastic tissue layer that lines a blood vessel layer
MP:0006084	abnormal circulating phospholipid level	any anomaly in the concentration in the blood of the fat derivatives in which one fatty acid has been replaced by a phosphate group
MP:0006085	myocardium necrosis	morphological changes resulting from pathological death of myocardial tissue; usually due to irreversible damage
MP:0006086	decreased body mass index	less than normal average of a measure of weight for height
MP:0006087	increased body mass index	greater than normal average of a measure of weight for height
MP:0006088	abnormal blood-cerebrospinal fluid barrier function	anomaly in the function of the group of barriers and transport systems in the choroid plexus located in the lateral, third, and fourth brain ventricles that controls the entrance of substances into the cerebrospinal fluid from the blood
MP:0006089	abnormal vestibular saccule morphology	any structural anomaly of the smaller of the two sacs in the vestibule
MP:0006090	abnormal utricle morphology	any structural anomaly of the larger of the two sacs in the vestibule
MP:0006092	abnormal olfactory sensory neuron morphology	any structural anomaly of the neurons in the olfactory epithelium that are activated by specific odorants
MP:0006093	arteriovenous malformation	fusion of an artery and vein without an intervening capillary bed
MP:0006094	increased fat cell size	increased size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals
MP:0006095	absent amacrine cells	absence of the amacrine cells, which constitute one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer
MP:0006096	absent retina bipolar cells	absence of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells
MP:0006097	abnormal cerebellar lobule formation	anomaly in the formation of the lobes of the cerebellum
MP:0006098	absent cerebellar lobules	missing lobes of the cerebellum
MP:0006099	thin cerebellar granule layer	reduced thickness of the innermost cortical layer of the cerebellum that contains granule cells
MP:0006100	abnormal tegmentum morphology	any structural anomaly of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct
MP:0006101	absent tegmentum	absence or loss of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct
MP:0006102	decreased tegmentum size	reduced size of the floor of the midbrain which extends from the substantia nigra to the level of the cerebral aqueduct
MP:0006103	abnormal midbrain roof plate morphology	any structural anomaly of the mesencephalic roof plate, including the caudal and rostral part of the midbrain roof
MP:0006104	abnormal tectum morphology	any structural anomaly of the rostral part of the midbrain roof
MP:0006105	small tectum	reduced size of the rostral part of the midbrain roof
MP:0006106	absent tectum	absence or loss of the rostral part of the midbrain roof
MP:0006107	abnormal fetal atrioventricular canal morphology	any structural anomaly of the common canal connecting the primordial atrium and ventricle during fetal development; the dorsal and ventral endocardial cushions develop in the walls of the common atrioventricular canal, grow toward each other and fuse, dividing the common atrioventricular canal into right and left atrioventricular canals and the atrioventricular septum
MP:0006108	abnormal hindbrain development	anomaly in the formation or pattering of the caudal region of the brain
MP:0006109	fibrillation	asynchronous contraction or quivering of individual cardiac muscle fibers
MP:0006110	ventricular fibrillation	asynchronous contraction or quivering of individual cardiac muscle fibers in the ventricles
MP:0006111	abnormal coronary circulation	any anomaly in the circulation of blood through the vessels that supply the heart
MP:0006112	angina	inadequate blood flow to and/or oxygenation of the heart producing chest pain
MP:0006113	abnormal heart septum morphology	any structural anomaly of the thin membranous structure between the two heart atria, the atria and the ventricles, or the thick muscular structure between the two heart ventricles
MP:0006114	cardiac murmur	abnormal turbulent blood flow through the valves or outflow tract results in abnormal heart sounds
MP:0006115	aortic valve atresia	congenital closure of the aortic valve
MP:0006116	calcified aortic valve	pathologic deposition of calcium salts in the aortic valve
MP:0006117	aortic valve stenosis	abnormal narrowing or constriction of the aortic valve
MP:0006118	aortic valve prolapse	collapse of one or more of the aortic valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps
MP:0006119	mitral valve atresia	congenital closure of the mitral valve
MP:0006120	mitral valve prolapse	collapse of one or more of the mitral valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps
MP:0006121	calcified mitral valve	pathologic deposition of calcium salts in the mitral valve
MP:0006122	mitral valve stenosis	abnormal narrowing or constriction of the mitral valve
MP:0006123	tricuspid valve atresia	congenital closure of the tricuspid valve
MP:0006124	tricuspid valve stenosis	abnormal narrowing or constriction of the tricuspid valve
MP:0006125	tricuspid valve prolapse	collapse of one or more of the tricuspid valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps
MP:0006126	abnormal cardiac outflow tract development	anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery and the ventricular outflow regions
MP:0006128	pulmonary valve stenosis	abnormal narrowing or constriction of the pulmonary valve
MP:0006129	pulmonary valve prolapse	collapse of one or more of the pulmonary valve cusps backward allowing blood to leak backwards, usually the result of enlargement of one or more of the valve cusps
MP:0006130	pulmonary valve atresia	congenital closure of the pulmonary valve
MP:0006131	calcified pulmonary valve	pathologic deposition of calcium salts in the pulmonary valve
MP:0006132	calcified tricuspid valve	pathologic deposition of calcium salts in the tricuspid valve
MP:0006133	calcified artery	pathologic deposition of calcium salts in the arteries
MP:0006134	artery occlusion	blockage of blood flow through one or more arteries
MP:0006135	artery stenosis	abnormal constriction or narrowing of one or more arteries
MP:0006136	varicose veins	enlarged, twisted, painful superficial veins resulting from poorly functioning valves
MP:0006137	venoocclusion	blockage of blood flow through one or more veins
MP:0006138	congestive heart failure	cardiac output is insufficient to supply blood throughout the body, resulting in the accumulation of fluid in the lungs and other body tissues; it is related mainly to salt and water retention in the tissues rather than directly to reduced blood flow; blood pools in the veins (vascular congestion) because the heart does not pump efficiently enough to allow it to return
MP:0006140	increased cardiac rhabdomyoma incidence	greater than the expected number of a benign tumor of the myocardium, occurring in a specific population in a given time period; it is most commonly seen in the young and is often associated with tuberous sclerosis
MP:0006141	abnormal atrioventricular node conduction	anomaly in the generation or transfer of cardiac electrical impulses from the atrioventricular node to the atrioventricular bundle
MP:0006142	abnormal sinoatrial node conduction	anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles
MP:0006143	increased systemic arterial diastolic blood pressure	abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed
MP:0006144	increased systemic arterial systolic blood pressure	abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries
MP:0006145	legal blindness	the best corrected visual acuity is 20/200, or the visual field is 20 degrees or less (sensu H. sapiens)
MP:0006147	monocular blindness	loss of vision in only one eye, may be transient
MP:0006148	binocular blindness	loss of vision in both eyes, may be transient
MP:0006149	decreased visual acuity	loss of visual acuity or ability to distinguish small details
MP:0006150	double vision	two images are perceived when only a single object is present
MP:0006151	cornea astigmatism	the cornea is asymmetrically curved, causing out-of-focus vision
MP:0006152	tunnel vision	loss of peripheral vision
MP:0006153	hypermetropia	light entering the eye focuses behind the retina, instead of directly on it
MP:0006154	eye abduction	abnormal movement of the eye laterally, or towards the temple
MP:0006155	eye adduction	abnormal movement of the eye medially, or towards the nose
MP:0006156	abnormal visual pursuit	anomaly in the ability to selectively track a moving object
MP:0006157	palsy of the eye	the eye fails to move properly in all directions of gaze
MP:0006158	vertical supranuclear palsy	inability to move the eye vertically
MP:0006159	ocular albinism	absence of melanin (pigment) production in the eye with identifiable melanocytes present
MP:0006160	heterochromatic iridis	a difference in color between the irises of the two eyes or between parts of one iris
MP:0006162	thick eyelids	increased width of the eyelid
MP:0006163	ankyloblepharon filiform	abnormal connection of the upper and lower eyelids formed by fibrous tissue
MP:0006164	ectropion	abnormal eversion of the upper or lower eyelid that leaves the eye exposed and dry
MP:0006165	entropion	abnormal inward rolling of the eyelid, most commonly the lower lid
MP:0006166	eyelid retraction	abnormal superior displacement of resting upper lid margin or abnormal inferior displacement of resting lower lid margin
MP:0006167	eyelid edema	an abnormal accumulation of fluid in the eyelid
MP:0006168	epicanthus inversus	a vertical fold of skin runs from the lower eyelid up either side of the nose
MP:0006169	increased eyelid tumor incidence	greater than the expected number of abnormal rapidly proliferating cells in the eyelid, usually in the form of a distinct mass, occurring in a specific population in a given time period
MP:0006170	increased eyelid myxoma incidence	higher than normal incidence of a benign neoplasm derived from pluripotential mesenchymal stem cells of eyelid connective tissue, consisting chiefly of polyhedral and stellate cells that are loosely embedded in a soft mucoid matrix
MP:0006171	increased eyelid neuroma incidence	greater than the expected number of a tumor composed of nerve tissue found in the eyelid, occurring in a specific population in a given time period
MP:0006172	increased eyelid lipodermoid incidence	greater than the expected number of a congenital, yellowish-white, fatty, benign tumor located beneath the conjunctiva of the eye, occurring in a specific population in a given time period
MP:0006173	abnormal myeloid dendritic cell morphology	any structural anomaly of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses
MP:0006175	choroid atrophy	acquired diminution of the size of the choroid associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0006176	choroid degeneration	a retrogressive impairment of function or destruction of the choroid
MP:0006177	choroid sclerosis	thickening or hardening of the choroid usually secondary to atrophy
MP:0006180	increased choroid hemangioma incidence	greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the choroid, occurring in a specific population in a given time period
MP:0006182	increased retina hemangioma incidence	greater than the expected number of a benign tumor characterized by blood-filled spaces lined by benign endothelial cells in the retina, occurring in a specific population in a given time period
MP:0006183	increased retina hamartoma incidence	greater than the expected number of a benign formation of a mass of tissue of disproportionate size and distribution in the retina, occurring in a specific population in a given time period; hamartomas are typically composed of an overgrowth of mature cells and tissues that normally occur in this tissue
MP:0006184	increased retina astrocytoma incidence	greater than the expected number of a malignant tumor of nervous tissue composed of well-differentiated astrocytes located in the retina, occurring in a specific population in a given time period
MP:0006185	retina hemorrhage	bleeding into the retina
MP:0006186	retina fibrosis	invasion of fibrous connective tissue into the retina, often resulting from inflammation or injury
MP:0006187	retina deposits	abnormal accumulation of material on the retina
MP:0006188	calcified retina	pathologic deposition of calcium salts in the retina
MP:0006190	retina ischemia	inadequate blood flow to the retina usually due to functional constriction or obstruction of a blood vessel
MP:0006191	conjunctival deposits	abnormal accumulation of material on the conjunctiva
MP:0006192	abnormal conjunctival vasculature morphology	any structural anomaly of the blood vessel network of the conjunctiva
MP:0006193	conjunctival telangiectasia	vascular lesion formed by dilation of a group of small blood vessels in the conjunctiva
MP:0006194	keratoconjunctivitis	inflammation of the conjunctiva and cornea
MP:0006197	ocular hypotelorism	decreased interpupillary distance, i.e. decreased distance between the center of the pupils of the two eyes
MP:0006198	enophthalmos	recession of the eyeball within the orbit
MP:0006199	hypertropia	vertical misalignment between the eyes
MP:0006200	vitreous body deposition	abnormal accumulation of material in the vitreous body
MP:0006201	vitreous body inflammation	local accumulation of fluid, plasma proteins, and leukocytes in the vitreous body
MP:0006202	vitreous body hemorrhage	bleeding into the vitreous body
MP:0006203	eye hemorrhage	bleeding into the eye
MP:0006204	embryonic lethality before implantation	death anytime between fertilization and implantation (Mus: E0 to less than E4.5)
MP:0006205	embryonic lethality between implantation and somite formation	death anytime between the point of implantation and somite formation (Mus: E4.5 to less than E8)
MP:0006206	embryonic lethality between somite formation and embryo turning	death anytime between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)
MP:0006207	embryonic lethality during organogenesis	death anytime between embryo turning and the completion of organogenesis (Mus: E9-9.5 to less than E14)
MP:0006208	lethality throughout fetal growth and development	death anytime between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)
MP:0006209	calcified intraocular region	pathologic deposition of calcium salts in the eye
MP:0006210	abnormal orbit size	deviation from the normal size of the orbit
MP:0006211	small orbits	reduced size of the orbits
MP:0006212	large orbits	increased size of the orbits
MP:0006213	shallow orbits	decrease in the depth of the orbit
MP:0006214	asymmetrical orbits	loss of bilateral symmetry in the orbits
MP:0006216	abnormal optic disk size	deviation from the normal size of the optic disk
MP:0006217	small optic disk	reduced size of the optic disk
MP:0006218	large optic disk	increased size of the optic disk
MP:0006219	optic nerve degeneration	an active retrogressive pathologic deterioration of the optic nerve due to processes such as aberrant damage repair from injury, impaired blood flow or aging
MP:0006220	optic nerve compression	a flattened or pressed appearance of the optic nerve as if by applied pressure
MP:0006221	optic nerve hypoplasia	decrease in the number of normal cells in normal arrangement in the optic nerve, typically resulting in decreased size
MP:0006222	optic neuropathy	damage of the optic nerve due to a blockage of its blood supply, to nutritional deficiencies, or to toxins
MP:0006223	optic nerve swelling	accumulation of an excessive amount of fluid in the optic nerve; usually associated with an increase in intraocular pressure
MP:0006224	oculomotor apraxia	impaired control of horizontal eye movements
MP:0006225	ocular rupture	tearing of the tissues of the eye
MP:0006226	iris hypoplasia	decrease in the number of normal cells in normal arrangement in the iris, typically resulting in decreased size
MP:0006228	iris atrophy	acquired diminution of the size of the iris associated with wasting as from death and reabsorption of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes
MP:0006229	iris inflammation	local accumulation of fluid, plasma proteins and leukocytes in the iris
MP:0006230	iris stroma hypoplasia	decrease in the number of normal cells in normal arrangement in the iris stroma, typically resulting in decreased size
MP:0006232	increased Lisch nodule incidence	greater than the expected number of benign focal malformations in the iris in a specific population in a given time period; results from faulty iris development, and is composed of an abnormal mixture of tissue elements including melanocytes, or an abnormal proportion of a single element normally present at that site
MP:0006234	iridoschisis	separation of the anterior iris stroma from the posterior stroma and muscle layers
MP:0006235	polycoria	two or more pupils in one iris each with sphincter muscle
MP:0006236	absent Meibomian glands	missing meibomian glands
MP:0006237	abnormal choroid vasculature morphology	any structural anomaly of the blood vessels of the choroid
MP:0006238	abnormal choriocapillaris morphology	any structural anomaly of the capillaries forming the inner vascular layer of the choroid of the eye
MP:0006239	absent choriocapillaris	missing capillaries forming the inner vascular layer of the choroid of the eye
MP:0006240	anisocoria	unequal size of pupils
MP:0006241	abnormal placement of pupils	abnormal location of the pupil so that it is not in the center of the iris
MP:0006242	white pupil	reflective white mass within the eye that gives the appearance of white pupil
MP:0006243	impaired pupillary reflex	the pupil fails to constrict fully when exposed to bright light
MP:0006244	eyelid muscle spasm	repetitive, involuntary spasm of the eyelid muscles; a twitch usually occurs in the upper eyelid, but it can occur in both the upper and lower eyelids
MP:0006245	obsolete dislocated lens	OBSOLETE. the lens is moved out of position because some or all of the supporting ligaments have broken
MP:0006248	lagophthalmos	inability to completely close the eye
MP:0006249	phthisis bulbi	small, shrunken, malformed eye that usually represents an acquired shrinkage of the eye following trauma, infection, or the end result of eye disease rather than a primary developmental defect
MP:0006250	abnormal line of Schwalbe morphology	any structural anomaly of the thickened peripheral margin of the vitreous membrane of the cornea
MP:0006251	eyelid apraxia	impaired ability to open the eyelids without any gross defect in eyelid morphology
MP:0006252	lateral rectus palsy	paralysis of the lateral rectus muscle preventing medially deviated and movement laterally from the midline
MP:0006253	clinodactyly	abnormal lateral curvature of one or more digits towards or away from each other
MP:0006254	thin cerebral cortex	decreased depth of the mantle covering the surface of the cerebral hemispheres
MP:0006256	abnormal gustatory papillae morphology	any structural anomaly of the papillae that contain taste buds, including the fungiform, foliate, and circumvallate papillae
MP:0006257	abnormal fungiform papillae morphology	any structural anomaly of the mushroom-shaped papillae, which have a single taste bud at the tip, located mostly on the dorsal anterior portion of the tongue
MP:0006258	abnormal circumvallate papillae morphology	any structural anomaly of the large papillae, which have multiple taste buds in the trough surrounding the papillae, located near the base and on the dorsal side of the tongue
MP:0006259	abnormal foliate papillae morphology	any structural anomaly of the papillae located on the sides of the tongue
MP:0006260	abnormal gustatory papilla taste bud morphology	any structural anomaly of the lingual taste buds found exclusively within gustatory papillae of the tongue, including the circumvallate, foliate, and fungiform papillae
MP:0006261	annular pancreas	an abnormal ring or collar of pancreatic tissue that encircles the duodenum
MP:0006262	increased testis tumor incidence	greater than the expected number of abnormal rapidly proliferating cells in the testis, usually in the form of a distinct mass, occurring in a specific population in a given time period
MP:0006263	decreased systemic arterial diastolic blood pressure	abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed
MP:0006264	decreased systemic arterial systolic blood pressure	abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries
MP:0006265	increased pulse pressure	increase in the difference between systolic and diastolic blood pressure
MP:0006266	decreased pulse pressure	decrease in the difference between systolic and diastolic blood pressure
MP:0006267	abnormal intercalated disk morphology	any structural anomaly in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes; the intercalated discs permit communication between the cells such that there is a sequential contraction of the cells from the bottom of the ventricle to the top, facilitating maximal ejection of blood from the ventricle during contraction
MP:0006268	absent cardiac desmosomes	absence of one type of membrane junctions found within the intercalated discs that provide mechanical integrity and prevent separation of adjacent cells during contraction of cardiac tissue
MP:0006269	abnormal mammary gland growth during pregnancy	anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation in preparation for lactation
MP:0006270	abnormal mammary gland growth during lactation	anomaly in the final stage of mammary growth that occurs during the start of lactation
MP:0006271	abnormal involution of the mammary gland	anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost
MP:0006272	abnormal urine organic anion level	any change in the amount of organic anions in the urine
MP:0006273	abnormal urine organic cation level	any change in the amount of organic cations in the urine
MP:0006274	abnormal urine sodium level	any change in the amount of sodium in the urine
MP:0006276	abnormal autonomic nervous system physiology	any functional anomaly of the function of the sensory and motor neurons that run between the central nervous system (especially the hypothalamus and medulla oblongata) and various internal organs (heart, lungs, endocrine and exocrine glands), responsible for controlling involuntary bodily functions
MP:0006277	abnormal parasympathetic nervous system physiology	any functional anomaly of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system
MP:0006278	aortic aneurysm	a protruding sac formed by the dilation of the wall of the aorta resulting from a weakening of the vessel wall
MP:0006279	abnormal limb development	anomaly in the formation of the limbs
MP:0006280	abnormal digit development	anomaly in the formation of the digits
MP:0006281	abnormal tail development	anomaly in the formation of the tail
MP:0006282	abnormal spinal cord dorsal horn morphology	any structural anomaly of the pronounced, dorsolaterally oriented ridge of grey matter in each lateral half of the spinal cord
MP:0006283	increased medulloblastoma incidence	greater than the expected number of a solid, cancerous tumor originating in the cerebellum of the brain and of primitive neuroectodermal origin, occurring in a specific population in a given time period
MP:0006284	absent hypaxial muscle	absence of the muscles derived from the lateral myotome and lateral portion of the dermomyotome; these include the thoracic intercostal and abdominal muscles, limb muscles and superficial back muscles, as well as the diaphragm and the tip of the tongue
MP:0006285	absent inner ear	absence of all components of the labyrinth, including the semicircular canals, vestibule and cochlea
MP:0006286	inner ear hypoplasia	decrease in the number of normal cells in normal arrangement in the inner ear, typically resulting in decreased size
MP:0006287	inner ear cyst	presence of one or more abnormal membranous sacs in any component of the labyrinth, including the semicircular canals, vestibule and cochlea
MP:0006288	small otic capsule	reduced size of the cartilage or bony capsule surrounding the inner ear mechanism
MP:0006289	otic capsule hypoplasia	decrease in the number of normal cells in normal arrangement in the otic capsule, typically resulting in decreased size
MP:0006290	proboscis	a long, cylindrical protuberance of the face that, in cyclopia or ethmocephaly, represents the nose
MP:0006291	aprosencephaly	derivatives of the telencephalon and diencephalon are absent or dysplastic but more caudal brain structures are largely normal or only mildly deformed
MP:0006292	abnormal nasal placode morphology	any structural anomaly in the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose
MP:0006293	absent nasal placodes	absence of the paired ectodermal placodes that come to lie in the bottom of the olfactory pits as the pits are deepened by the growth of the surrounding medial and lateral nasal processes; the nasal placode gives rise to the olfactory epithelium of the nose
MP:0006294	absent optic vesicle	absence of the hollow outgrowth from the lateral aspects of the embryonic forebrain from which the retina and optic nerve develop
MP:0006295	absent sclerotome	absence of the group of mesenchymal cells that emerge from the ventromedial part of a somite and migrate toward the notochord to give rise to the ribs and vertebrae
MP:0006296	arachnodactyly	the digits are abnormally long and slender
MP:0006297	obsolete loss of abdominal adipose tissue	OBSOLETE. reduction in amount or absence of adipose tissue associated with internal organs
MP:0006298	abnormal platelet activation	anomaly in the series of progressive, overlapping events triggered by exposure of platelets to signals from subendothelial tissue, including shape change, adhesiveness, aggregation, and release reactions; when carried through to completion, these events lead to the formation of a stable hemostatic plug
MP:0006299	abnormal latent inhibition of conditioning behavior	anomaly in the impairment in a conditioned response seen after repeated unpaired presentations of the conditioned stimulus prior to pairing it with the unconditioned stimulus
MP:0006300	abnormal entorhinal cortex morphology	any structural anomaly of the structure in the anterior parahippocampus that lies forward of the parahippocampal cortex and immediately medial to the perirhinal cortex, bounded superiorly by the hippocampus and inferiorly by the collateral sulcus
MP:0006301	abnormal mesenchyme morphology	any structural anomaly of the loosely packed, unspecialized cells that derive mostly from the mesoderm and contribute to connective tissue, bone, cartilage and circulatory and lymphatic systems
MP:0006302	abnormal ectomesenchyme morphology	any structural anomaly in the mesenchymal cells derived from neural crest cells that contribute to development of the hard and soft tissue in the head and neck, including the branchial arches
MP:0006303	abnormal retina nerve fiber layer morphology	any structural anomaly of the layer of the retina formed by expansion of the fibers of the optic nerve
MP:0006305	abnormal optic eminence morphology	any structural anomaly of the embryonic structure that gives rise to the corneal ectoderm
MP:0006306	abnormal nasal pit morphology	any structural anomaly of one or both of a pair of depressions formed in the developing face that give rise to the rostral portion of the nasal meatus; the nasal pits indent the fronto-nasal process and divide it into a medial and two lateral nasal processes
MP:0006307	abnormal seminiferous tubule size	alteration in the diameter of the tubules in the testes where spermatogenesis occurs
MP:0006308	enlarged seminiferous tubules	increased diameter of the tubules in the testes where spermatogenesis occurs
MP:0006309	decreased retina ganglion cell number	reduced number of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
MP:0006310	increased retinoblastoma incidence	higher than normal incidence of a malignant tumor of the retina composed of cells arising from the retinoblasts
MP:0006315	abnormal urine protein level	anomaly in the amount of protein in the urine
MP:0006316	increased urine sodium level	higher than normal amount of sodium in the urine
MP:0006317	decreased urine sodium level	lower than normal amount of sodium in the urine
MP:0006319	abnormal epididymal fat pad morphology	any structural anomaly of the encapsulated adipose tissue associated with the epididymis
MP:0006320	abnormal interscapular fat pad morphology	any structural anomaly of the encapsulated adipose tissue located between the scapulae
MP:0006321	increased myocardial fiber number	increased number of the terminally differentiated, non-proliferative, cardiac muscle fibers, the multinucleated muscle cells of the heart
MP:0006322	abnormal perichondrium morphology	any structural anomaly of the fibrous connective tissue that surrounds all non-joint end cartilage
MP:0006323	abnormal extraembryonic mesoderm development	malformation of the mesoderm of the extraembryonic tissue that is involved in forming the amnion, chorion, yolk sac, and body stalk
MP:0006324	abnormal cochlear nerve fiber response	anomaly in the electrophysiological recordings from a single or several auditory nerve fiber(s)
MP:0006325	impaired hearing	reduced ability to perceive auditory stimuli
MP:0006326	conductive hearing impairment	reduction in the ability to hear due to lesions in the external auditory canal or middle ear
MP:0006327	mixed hearing impairment	reduced ability to hear resulting from a combination of conductive and sensorineural hearing impairment
MP:0006328	nonsyndromic hearing impairment	a form of hearing impairment that is not associated with visible abnormalities of the external ear or other signs and symptoms; the vast majority of hereditary hearing loss is nonsyndromic and can be associated with abnormalities of the middle ear and/or inner ear
MP:0006329	sensorineural hearing impairment	a form of hearing impairment due to a lesion of the auditory division of cranial nerve VIII or the inner ear
MP:0006330	syndromic hearing impairment	hearing impairment that is usually associated with malformations of the external ear and other inherited signs and symptoms
MP:0006331	abnormal patterning of the organ of Corti	anomaly in the organization of the various cell types within the organ of Corti into a set number of distinct rows
MP:0006332	abnormal cochlear potential	anomaly in the evoked response of the cochlea
MP:0006334	abnormal susceptibility to hearing loss	anomaly in the sensitivity to loss of hearing related to age or environmental factors
MP:0006335	abnormal hearing electrophysiology	anomaly in auditory function as it relates to electrical phenomena
MP:0006336	abnormal otoacoustic response	anomaly in the acoustic energy produced by the cochlea in the presence or absence of sound stimulation
MP:0006337	abnormal first pharyngeal arch morphology	any structural anomaly of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery
MP:0006338	abnormal second pharyngeal arch morphology	any structural anomaly of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils
MP:0006339	abnormal third pharyngeal arch morphology	any structural anomaly of the third arch which contributes to the development of the hyoid bone, stylopharyngeus muscle, inferior parathyroid gland, and thymus
MP:0006340	abnormal fourth pharyngeal arch morphology	any structural anomaly of the fourth arch which contributes to development of the cartilage of the larynx, laryngeal, pharyngeal, and soft palate muscles, superior parathyroid gland, and C-cells of the thymus
MP:0006341	small first pharyngeal arch	reduced size of the first branchial arch
MP:0006342	absent first pharyngeal arch	absence of the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel's cartilage, trigeminal nerve, and maxillary artery
MP:0006343	enlarged first pharyngeal arch	increased size of the first branchial arch
MP:0006344	small second pharyngeal arch	reduced size of the second branchial arch
MP:0006345	absent second pharyngeal arch	absence of the structure of the second arch which contributes to the development of the stapes, styloid process, hyoid bone, stylohyoid ligament, muscles of facial expression, stapedius muscle, stylohyoid muscle, and lining of the palatine tonsils
MP:0006346	small pharyngeal arch	reduced size of one or more of the branchial arches
MP:0006347	abnormal sixth pharyngeal arch morphology	any structural anomaly of the sixth arch which contributes to the development of the sternocleidomastoid and trapezius muscles
MP:0006348	abnormal circulating copper level	any anomaly in the blood concentration of copper
MP:0006349	decreased circulating copper level	less than the normal concentration of copper in the blood
MP:0006350	increased circulating copper level	greater than normal concentration of copper in the blood
MP:0006351	abnormal glycosylated hemoglobin level	aberrant concentration in the blood of modified form of hemoglobin with an attached saccharide molecule; this is commonly used to estimate blood glucose levels over the lifespan of the red blood cell
MP:0006352	decreased glycosylated hemoglobin level	lower than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule
MP:0006353	increased glycosylated hemoglobin level	greater than normal blood concentration of a modified form of hemoglobin with an attached saccharide molecule
MP:0006354	abnormal fourth pharyngeal arch artery morphology	any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis
MP:0006355	abnormal sixth pharyngeal arch artery morphology	any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis
MP:0006356	abnormal third pharyngeal arch artery morphology	any structural anomaly of the vessels formed within the third pair of branchial arches in embryogenesis
MP:0006357	abnormal circulating mineral level	any anomaly in the concentration in the blood of any naturally occurring, homogeneous inorganic solid substance having a definite chemical composition and highly ordered atomic arrangement that is required for growth and survival
MP:0006358	absent pinna reflex	complete failure to respond to an auditory stimulus by a characteristic ear twitch
MP:0006359	absent startle reflex	failure to respond to variable stimuli, often auditory; usually measured by amplitude of whole body flinch
MP:0006361	abnormal female germ cell morphology	any structural anomaly female germ cells whether they are undifferentiated or fully differentiated
MP:0006362	abnormal male germ cell morphology	any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated
MP:0006363	absent auchene hairs	absence of truncal hairs having a single constriction and bend about midway along the hair shaft, and contain two or more air cells in the medulla
MP:0006364	absent awl hair	absence of truncal hairs that are straight, but are shorter than guard hairs, and contain two or more air cells in the medulla
MP:0006365	absent guard hair	absence of the long, straight truncal hairs that contain two air cells in the medulla
MP:0006366	absent zigzag hairs	absence of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla
MP:0006367	absent sweat gland	absence of any of the coil glands of the skin that secrete sweat
MP:0006369	supernumerary incisors	more than the usual number of incisors, normally consisting of two pairs, top and bottom, of the long teeth that are the most anterior and prominent in the jaw
MP:0006370	abnormal hair follicle pheomelanosome pheomelanin content	anomaly in the amount or distribution of yellow pigment in the hair follicle
MP:0006371	absent hair follicle pheomelanosome pheomelanin	yellow pigment is not present in pheomelanosomes of the hair follicle
MP:0006372	impaired placental function	reduction in the ability of the placenta to supply nutrients or remove waste
MP:0006373	abnormal circulating angiotensinogen level	anomaly in the concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I
MP:0006374	obsolete abnormal blood osmolality	OBSOLETE. anomaly in the concentration of ions in the blood
MP:0006375	increased circulating angiotensinogen level	greater than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I
MP:0006376	decreased circulating angiotensinogen level	less than normal concentration of the serum globulin formed by the liver that is cleaved by renin to form angiotensin I
MP:0006377	abnormal vestibulocollic reflex	any anomaly in the neural reflex which results from activation of afferents from the vestibular organs and uses neck movements to stabilize the head position in space
MP:0006378	abnormal spermatogonia morphology	any structural anomaly of the large unspecialized male germ cells that give rise to spermatocytes
MP:0006379	abnormal spermatocyte morphology	any structural anomaly of male germ cells that through meiosis give rise to spermatids
MP:0006380	abnormal spermatid morphology	any structural anomaly of the male germ cells that without further cell division give rise to mature spermatozoa
MP:0006382	abnormal lung epithelium morphology	any structural anomaly of the epithelial layer of the lung
MP:0006383	abnormal cochlear frequency tuning	any anomaly in the frequency resolution of the cochlea, normally determined by the passive mechanical properties of the basilar membrane and active feedback from the outer hair cells which detect and amplify sound-induced basilar membrane motions
MP:0006384	enhanced cochlear frequency tuning	increase in the sharpness of frequency resolution of the cochlea
MP:0006386	absent somites	absence of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo
MP:0006387	abnormal T cell number	deviation from the normal count of T cells
MP:0006388	abnormal auditory summating potential	any anomaly in the dc shift in the waveform sustained for the duration of a toneburst stimulus that represents the depolarization of sensory hair cells in the cochlea; positive summating potentials (SPs) reflect activity of basal turn hair cells while negative SPs are derived from hair cell activity in the apical turn; negative SPs tend to be obtained at low frequencies and low intensities of stimulus, while positive SPs are recorded in response to high frequencies and high intensities
MP:0006389	abnormal vestibular endolymph physiology	change in the normal production (volume) or ionic homeostasis of the fluid contained within the vestibule of the inner ear; unlike cochlear endolymph this fluid does not have a high potential
MP:0006390	abnormal cochlear endolymph physiology	change in the normal production (volume) or ionic homeostasis of the fluid contained within the cochlea of the inner ear
MP:0006391	abnormal vestibular endolymph ionic homeostasis	anomaly in the processes involved in the maintenance of an internal equilibrium of charged molecules in the vestibular endolymph
MP:0006392	abnormal nucleus pulposus morphology	any structural anomaly of the jelly-like substance in the middle of the spinal disc which is a remnant of the notochord
MP:0006393	absent nucleus pulposus	missing the notochord remnant normally found in the center of the intervertebral disc
MP:0006394	abnormal vertebral epiphyseal plate morphology	any structural anomaly of the lateral cartilaginous centers of ossification; may be found on the lateral, upper, and/or lower surfaces of the vertebrae at different times during development
MP:0006395	abnormal epiphyseal plate morphology	any structural anomaly of the cartilaginous center of ossification on the bones permitting growth of the bone in both directions during development
MP:0006396	decreased long bone epiphyseal plate size	reduced size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles
MP:0006397	disorganized long bone epiphyseal plate	a lack of the regular arrangement of the cells or zones of the epiphyseal plate
MP:0006398	increased long bone epiphyseal plate size	greater than the normal size of the cartilaginous center of ossification located at one or both ends of bones between the epiphysis (end) and the diaphysis (shaft) of long bones; longitudinal growth of the bone occurs at the plate during development in children and juveniles
MP:0006399	abnormal long bone epiphyseal ossification zone morphology	any structural anomaly of the layer of the epiphyseal plate where new bone matrix is deposited
MP:0006400	decreased molar number	reduction in the number of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface
MP:0006401	absent male preputial gland	a lack of the sebaceous glands of the corona and neck of the glans penis
MP:0006402	small molars	reduced size of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface
MP:0006403	abnormal cochlear endolymph ionic homeostasis	anomaly in the state of equilibrium in the cochlear endolymph with respect to charged molecules; cochlear endolymph is not only an unusual extracellular fluid for its high potassium ion and low sodium ion concentration but also for its low calcium ion concentration, high HCO3- concentration and low protein content
MP:0006404	abnormal lumbar dorsal root ganglion morphology	any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the lumbar vertebrae
MP:0006405	abnormal L3 dorsal root ganglion morphology	any structural anomaly of the group of nerve cell bodies located on the dorsal spinal roots within the vertebral column at the level of the third lumbar vertebra
MP:0006408	dorsal root ganglion hypoplasia	decrease in the number of normal cells in normal arrangement in the dorsal root ganglion, typically resulting in decreased size
MP:0006409	vestibular ganglion hypoplasia	decrease in the number of normal cells in normal arrangement in the vestibular ganglion, typically resulting in decreased size
MP:0006410	abnormal common myeloid progenitor cell morphology	any structural anomaly of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage
MP:0006411	upturned snout	muzzle has a curve or tilt such that the tip points upwards
MP:0006412	abnormal T cell apoptosis	change in the timing or the number of T cells undergoing programmed cell death
MP:0006413	increased T cell apoptosis	increase in the number of T cells undergoing programmed cell death
MP:0006414	decreased T cell apoptosis	decrease in the number of T cells undergoing programmed cell death
MP:0006415	absent testes	absence of the male reproductive glands containing the germ cells
MP:0006416	abnormal rete testis morphology	any structural anomaly of the network of canals at the termination of the straight tubules in the mediastinum testis
MP:0006417	rete testis obstruction	any impediment or blockage of the network of canals at the termination of the straight tubules in the mediastinum testis
MP:0006418	abnormal testis cord formation	any structural anomaly in the formation of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence; defective testis cord formation is most likely to reflect abnormal function of either Sertoli cells or peritubular myoid (PTM) cells which normally cooperate to deposit a layer of basal lamina that defines the edges of individual testis cords
MP:0006419	disorganized testis cords	derangement of the pattern of the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence
MP:0006420	abnormal peritubular myoid cell morphology	any structural anomaly of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule
MP:0006421	decreased number of peritubular myoid cells	reduced number of the flattened smooth myoepithelial cells of mesodermal origin that lie just outside the basal lamina of the seminiferous tubule
MP:0006422	increased mammary adenoacanthoma incidence	higher than normal incidence of malignant tumors in which some cells have undergone squamous metaplasia in the mammary gland
MP:0006423	dilated rete testis	an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid
MP:0006424	absent testis cords	missing the attachments derived from the primordial seminiferous cords that differentiate into seminiferous tubules in adolescence
MP:0006425	absent Mullerian ducts	absence of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina
MP:0006426	Mullerian duct degeneration	a retrogressive impairment of function or destruction of the transient embryonic drainage tubes of the embryonic kidney (mesonephric tubules) that empty into the cloaca and in the female develop into the oviducts, uterus, and vagina
MP:0006427	ectopic Leydig cells	abnormal position of the testosterone-secreting cells normally found adjacent to the seminiferous tubules, within the interstitium of the testis
MP:0006428	ectopic Sertoli cells	abnormal position of the supporting cells of the seminiferous tubule epithelium that create the blood-testes barrier and enable spermatogenesis
MP:0006429	abnormal hyaline cartilage morphology	any structural anomaly of the bluish-white, glassy, translucent nonvascular, resilient, flexible connective tissue; found primarily in articular cartilage, costal cartilages, the nasal septum, the larynx, and the trachea
MP:0006430	abnormal elastic cartilage morphology	any structural anomaly of the nonvascular, resilient, flexible connective tissue containing elastin fibers; found primarily in the epiglottis, external ear, and auditory tubes
MP:0006431	abnormal fibrocartilage morphology	any structural anomaly of the nonvascular, resilient, flexible connective tissue containing thick bundles of collagenous fibers; found primarily in intervertebral disks
MP:0006432	abnormal costal cartilage morphology	any structural anomaly of the nonvascular, resilient, flexible hyaline connective tissue that connects the end of a true rib to the sternum or the end of a false rib with the with the lower border of the costal cartilage above it
MP:0006433	abnormal articular cartilage morphology	any structural anomaly of the thin layer of smooth hyaline cartilage located on the joint surfaces of a bone
MP:0008000	increased ovary tumor incidence	greater than the expected number of neoplams in the ovary occurring in a specific population in a given time period
MP:0008001	hypochlorhydria	reduced hydrochloric acid content of the gastric secretions
MP:0008002	hyperchlorhydria	increased hydrochloric acid content of the gastric secretions
MP:0008003	achlorhydria	absence of hydrochloric acid in the gastric secretions
MP:0008004	abnormal stomach pH	anomaly in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, as measured by the concentration of the hydrogen ion
MP:0008005	decreased stomach pH	change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is increased, as indicated by the increased concentration of hydrogen ion
MP:0008006	increased stomach pH	change in the function of the secretory and buffer systems of the stomach that control the relative acidity or alkalinity, such that the acidity is decreased, as indicated by the decreased concentration of hydrogen ion
MP:0008007	abnormal cellular replicative senescence	anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division
MP:0008008	early cellular replicative senescence	increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division
MP:0008009	delayed cellular replicative senescence	slower progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division
MP:0008010	increased gastric adenocarcinoma incidence	higher than normal incidence of a malignant neoplasm of epithelial cells in the stomach
MP:0008011	intestine polyps	abnormal tissue masses that protrude into the lumen of the intestine and are tethered to the wall of the intestine
MP:0008012	duodenum polyps	development of numerous growths that are connected to and protrude from the mucous membrane of the duodenum
MP:0008013	cecum polyps	development of numerous growths that are connected to and protrude from the mucous membrane of the cecum
MP:0008014	increased lung tumor incidence	greater than the expected number of neoplasms in the lung, usually in the form of a distinct mass, in a specific population in a given time period
MP:0008015	abnormal female inguinal canal morphology	any structural anomaly of the passage in the lower abdominal wall through which the round ligament, nerves and vessels pass from the pelvic cavity to labia majora
MP:0008016	abnormal male inguinal canal morphology	any structural anomaly of the passage in the lower abdominal wall through which the spermatic cord, nerves and vessels pass from the pelvic cavity to the scrotum
MP:0008017	inguinal cyst	presence of one or more benign epithelial growths in the wall of the inguinal canal
MP:0008018	increased facial tumor incidence	greater than the expected number of neoplasms on the face, usually in the form of a distinct mass, in a specific population in a given time period
MP:0008019	increased liver tumor incidence	greater than the expected number of neoplasms in the liver, usually in the form of a distinct mass, in a specific population in a given time period
MP:0008020	abnormal dermal mast cell morphology	any structural anomaly of cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation
MP:0008021	increased blastoma incidence	higher than normal incidence of a fast growing and invasive tumor composed chiefly or entirely of immature undifferentiated cells that have embryonic characteristics resembling the primordium of the organ in which the tumor arose
MP:0008022	dilated heart ventricle	the luminal space of one or both of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid
MP:0008023	abnormal styloid process morphology	any structural anomaly in the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone where it joins the tympanic portion; it gives attachment to the styloglossus, stylohyoid, and stylopharyngeus muscles and the stylohyoid and stylomandibular ligaments
MP:0008024	absent lymph nodes	absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched
MP:0008025	brain vacuoles	abnormal presence of fluid-filled vesicles in the soma of brain cells, often indicative of spongiosis or other pathological states
MP:0008026	abnormal brain white matter morphology	any structural anomaly of the regions of the brain that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites
MP:0008027	abnormal spinal cord white matter morphology	any structural anomaly of the regions of the spinal cord that are largely or entirely composed of myelinated nerve cell axons and contain few or no neural cell bodies or dendrites
MP:0008028	pregnancy-related premature death	death occurring before the normal life span of an organism, occurring during pregnancy, parturition or lactation
MP:0008029	abnormal paraxial mesoderm morphology	any structural anomaly of the mesoderm located bilaterally adjacent to the notochord and neural tube; on segmentation, paraxial mesoderm forms the paired somites
MP:0008030	abnormal Cajal-Retzius cell morphology	any structural anomaly of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus
MP:0008031	decreased Cajal-Retzius cell number	reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus
MP:0008032	abnormal lipolysis	anomaly in the process of the hydrolysis of fat into free fatty acids
MP:0008033	impaired lipolysis	reduction in the rate of the hydrolysis of fat into free fatty acids
MP:0008034	enhanced lipolysis	increase in the rate of the hydrolysis of fat into free fatty acids
MP:0008035	behavioral arrest	locomotor activity is interrupted by sudden periods of no movement
MP:0008036	abnormal NK T cell morphology	any structural anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008037	abnormal T cell morphology	any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation
MP:0008038	abnormal NK T cell number	deviation from the normal number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008039	increased NK T cell number	greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008040	decreased NK T cell number	reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008041	absent NK T cells	absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008042	abnormal NK T cell physiology	any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments
MP:0008043	abnormal NK cell number	deviation in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0008044	increased NK cell number	greater number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0008045	decreased NK cell number	reduction in the number of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0008046	absent NK cells	absence of lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0008047	absent uterine NK cells	absence of a natural killer cell subset that is found in the decidua of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy
MP:0008048	abnormal memory T cell number	deviation from the normal number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive
MP:0008049	increased memory T cell number	increase in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive
MP:0008050	decreased memory T cell number	reduction in the number of distinctly differentiated long-lived T cells that have the phenotype CD45RO-positive and CD127-positive
MP:0008051	abnormal memory T cell physiology	any functional anomaly of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response
MP:0008052	abnormal serous gland morphology	any structural anomaly of glands that secrete watery albuminous material that often contains enzymes
MP:0008053	abnormal NK cell differentiation	atypical production of or inability to produce mature lymphocytes that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells
MP:0008054	abnormal uterine NK cell morphology	any structural anomaly of a natural killer cell subset that is found in the decidual of the uterus, is CD56-high, Galectin-1-positive and CD16-negative, and is the most abundant immune cell type in the decidual during the first trimester of pregnancy
MP:0008055	increased urine osmolality	increase in the amount of ions in the urine compared to the normal state
MP:0008056	abnormal retina ganglion cell morphology	any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
MP:0008057	abnormal DNA replication	any anomaly in the process whereby new strands of DNA are synthesized
MP:0008058	abnormal DNA repair	any anomaly in the process of restoring DNA after damage or replication error
MP:0008059	abnormal podocyte foot process morphology	any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries
MP:0008060	abnormal podocyte slit diaphragm morphology	any structural anomaly of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream
MP:0008061	absent podocyte slit diaphragm	absence of the thin membrane that covers the podocyte filtration slit which allows small molecules such as water, glucose, and ionic salts to pass through while retaining larger macromolecules in the bloodstream
MP:0008062	abnormal podocyte slit junction morphology	any structural anomaly of the gaps between the interdigitated foot processes of the podocyte
MP:0008063	increased otic epithelial cell apoptosis	increase in the number of otic epithelial cells undergoing programmed cell death
MP:0008064	decreased otic epithelial cell proliferation	reduction in the expansion rate of the otic epithelial cell population by cell division
MP:0008065	short endolymphatic duct	length reduction or truncation of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac
MP:0008066	small endolymphatic duct	reduced size of the small membranous canal which connects with both saccule and utricle of the membranous labyrinth, passes through the aqueduct of vestibule, and terminates in the endolymphatic sac
MP:0008067	retina ganglion cell degeneration	degeneration or loss of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
MP:0008068	absent retina ganglion cell	absence of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain
MP:0008069	abnormal joint mobility	anomaly in the ability to move joints in a full range of motion and with ease
MP:0008070	absent T cells	absence of the lymphocytes that are responsible for cell-mediated immunity and immune system regulation
MP:0008071	absent B cells	absence of lymphocytes that expresses membrane-bound antibody, and differentiate into antibody-secreting plasma cells and memory cells upon interaction with antigen; B cells are the primary lymphocyte responsible for humoral immunity, and are most effective against extracellular pathogens
MP:0008072	absent double-negative T cells	absence of the subset of T cells found in the thymus that express neither CD4 nor CD8
MP:0008073	abnormal CD4-positive, alpha-beta T cell number	anomaly in the number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0008074	increased CD4-positive, alpha-beta T cell number	greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0008075	decreased CD4-positive, alpha-beta T cell number	reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0008076	abnormal CD4-positive T cell differentiation	atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production
MP:0008077	abnormal CD8-positive, alpha-beta T cell number	anomaly in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
MP:0008078	increased CD8-positive, alpha-beta T cell number	greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
MP:0008079	decreased CD8-positive, alpha-beta T cell number	reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
MP:0008080	abnormal CD8-positive, alpha-beta T cell differentiation	atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions
MP:0008081	abnormal single-positive T cell number	anomaly in the number of T cells bearing either CD4-positive or CD8-positive markers on their surface
MP:0008082	increased single-positive T cell number	greater number of T cells bearing either CD4 or CD8 markers on their surface
MP:0008083	decreased single-positive T cell number	reduced number of T cells bearing either CD4 or CD8 markers on their surface
MP:0008084	obsolete absent single-positive T cells	absence of T cells bearing either CD4 or CD8 markers on their surface
MP:0008085	abnormal T-helper 1 cell number	anomaly in the number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0008086	increased T-helper 1 cell number	greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0008087	decreased T helper 1 cell number	reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0008088	abnormal T-helper 1 cell differentiation	atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity
MP:0008089	abnormal T-helper 2 cell number	anomaly in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0008090	increased T-helper 2 cell number	greater number of the subset of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0008091	decreased T-helper 2 cell number	reduction in the number of the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0008092	abnormal T-helper 2 cell differentiation	atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy
MP:0008093	abnormal memory B cell number	anomaly in the number of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin
MP:0008094	absent memory B cells	absence of distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin
MP:0008095	abnormal memory B cell differentiation	atypical production of or inability to produce distinctly differentiated long-lived B cells that are readily activated upon reencounter of an antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin
MP:0008096	abnormal plasma cell number	anomaly in the number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0008097	increased plasma cell number	greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0008098	decreased plasma cell number	reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0008099	abnormal plasma cell differentiation	atypical production of or inability to produce terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0008100	absent plasma cells	absence of the terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin
MP:0008101	lymph node hypoplasia	decrease in the number of normal cells in normal arrangement in the lymph nodes, typically resulting in decreased size
MP:0008102	lymph node hyperplasia	increase in the number of normal cells in normal arrangement in the lymph nodes, typically resulting in increased size
MP:0008103	amacrine cell degeneration	a retrogressive impairment or destruction of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer
MP:0008104	abnormal amacrine cell number	anomaly in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina; they integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer
MP:0008105	increased amacrine cell number	increase in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina
MP:0008106	decreased amacrine cell number	reduction in the number of one of the three types of interneurons found in the inner nuclear layer of the mature retina
MP:0008107	absent retina horizontal cells	absence of the laterally interconnecting neurons in the outer plexiform layer of the retina that connect rods of one part of the retina with cones in another part of the retina
MP:0008108	abnormal small intestinal villus morphology	any structural anomaly of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold
MP:0008109	abnormal small intestinal microvillus morphology	any structural anomaly of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold
MP:0008111	abnormal granulocyte differentiation	atypical production of or inability to produce leukocytes that have abundant granules in the cytoplasm, including basophils, neutrophils, and eosinophils
MP:0008112	abnormal monocyte differentiation	atypical production of or inability to produce the large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood
MP:0008113	abnormal macrophage differentiation	atypical production of or inability to produce the large mononuclear phagocytes which differentiate from monocytes, are typically resident in a particular tissue, and capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells
MP:0008114	abnormal Kupffer cell morphology	any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids
MP:0008115	abnormal dendritic cell differentiation	atypical production of or inability to produce a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation
MP:0008117	abnormal Langerhans cell morphology	any structural anomaly of a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
MP:0008118	absent Langerhans cell	absence of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
MP:0008119	decreased Langerhans cell number	reduction in the number of stellate dendritic cells of myeloid origin, that appear clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus
MP:0008120	abnormal myeloid dendritic cell number	anomaly in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses
MP:0008121	increased myeloid dendritic cell number	greater number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses
MP:0008122	decreased myeloid dendritic cell number	reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses
MP:0008123	abnormal plasmacytoid dendritic cell number	anomaly in the number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli
MP:0008124	decreased plasmacytoid dendritic cell number	reduced number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli
MP:0008125	abnormal dendritic cell number	anomaly in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation
MP:0008126	increased dendritic cell number	greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation
MP:0008127	decreased dendritic cell number	reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation
MP:0008128	abnormal brain internal capsule morphology	any structural anomaly of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord
MP:0008129	absent brain internal capsule	absence of the area of white matter in the brain that lies between the lenticular and caudate nuclei, and contains a group of myelinated ascending and descending axonal fiber tracts that connects the cerebral cortex to the brain stem and spinal cord
MP:0008130	abnormal pituitary intermediate lobe morphology	any structural anomaly of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults
MP:0008131	abnormal Peyer's patch number	anomaly in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008132	increased Peyer's patch number	greater number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008133	decreased Peyer's patch number	reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008134	abnormal Peyer's patch size	anomaly in the size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008135	small Peyer's patches	reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008136	enlarged Peyer's patches	increased size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densely packed B cell follicles
MP:0008137	absent podocytes	absence of a modified epithelial cell of the visceral layer of the Bowman capsule in the renal corpuscle; it has a small perikaryon and a number of primary and secondary foot processes that interdigitate with those of other podocytes and are attached to the outer surface of the glomerular capillary basement membrane
MP:0008138	absent podocyte foot process	absence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries
MP:0008139	fused podocyte foot processes	coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries
MP:0008140	podocyte foot process effacement	a podocyte reaction to injury or damage characterized by flattening of foot processes due to gradual simplification of the interdigitating foot process; the whole podocyte looks flat due to retraction, widening, and shortening of the processes of each podocyte while the frequency of filtration slits is reduced, giving the appearance of a continuous cytoplasmic sheet covering the glomerular basement membrane
MP:0008141	decreased small intestinal microvillus size	reduced size of the additional extensions of the villi of the small intestine which protrude from the apical surface of the epithelial cells lining the villi; the microvilli increase the absorptive surface area of the small intestine by approximately 600-fold
MP:0008142	decreased small intestinal villus size	reduced size of the tiny hair-like projections that protrude from the inside of the small intestine that contain blood vessels that capture digested nutrients that are absorbed through the intestinal wall; the villi increase the absorptive surface area of the small intestine by approximately 30-fold
MP:0008143	abnormal dendrite morphology	any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body
MP:0008144	nyctalopia	decreased ability to see clearly in reduced illumination; often due to a deficiency of vitamin A or to a retinal disorder
MP:0008145	hemeralopia	reduced ability to see clearly in bright light with night vision remaining unchanged; often due to impaired retinal cone function
MP:0008146	asymmetric sternocostal joints	loss of bilateral symmetry in rib attachments to the sternum
MP:0008147	asymmetric costovertebral joints	loss of bilateral symmetry in rib attachments to the vertebral column
MP:0008148	abnormal sternocostal joint morphology	any anomaly in the normal joining of the ribs to the sternum
MP:0008149	abnormal costovertebral joint morphology	any anomaly in the normal joining of the ribs to the vertebral column, these connections are made by costovertebral ligaments between the head of the rib and the body of the thoracic vertebra
MP:0008150	decreased diameter of long bones	reduced width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge
MP:0008151	increased diameter of long bones	increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge
MP:0008152	decreased diameter of femur	reduced width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge
MP:0008153	decreased diameter of fibula	reduced width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge
MP:0008154	decreased diameter of humerus	reduced width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge
MP:0008155	decreased diameter of radius	reduced width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge
MP:0008156	decreased diameter of tibia	reduced width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge
MP:0008157	decreased diameter of ulna	reduced width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge
MP:0008158	increased diameter of femur	increased width of the cross-sectional distance that extends from one lateral edge of the femur, through its center and to the opposite lateral edge
MP:0008159	increased diameter of fibula	increased width of the cross-sectional distance that extends from one lateral edge of the fibula, through its center and to the opposite lateral edge
MP:0008160	increased diameter of humerus	increased width of the cross-sectional distance that extends from one lateral edge of the humerus, through its center and to the opposite lateral edge
MP:0008161	increased diameter of radius	increased width of the cross-sectional distance that extends from one lateral edge of the radius, through its center and to the opposite lateral edge
MP:0008162	increased diameter of tibia	increased width of the cross-sectional distance that extends from one lateral edge of the tibia, through its center and to the opposite lateral edge
MP:0008163	increased diameter of ulna	increased width of the cross-sectional distance that extends from one lateral edge of the ulna, through its center and to the opposite lateral edge
MP:0008164	abnormal B-1a B cell morphology	any structural anomaly of the B-1 B cell subset bearing the CD5 surface marker
MP:0008165	abnormal B-1b B cell morphology	any structural anomaly of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell
MP:0008166	abnormal B-2 B cell morphology	any structural anomaly of a conventional B cell subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells
MP:0008167	increased B-1a cell number	greater number of the B-1 B cell subset bearing the CD5 surface marker
MP:0008168	decreased B-1a cell number	reduced number of the B-1 B cell subset bearing the CD5 surface marker
MP:0008169	increased B-1b cell number	greater number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell
MP:0008170	decreased B-1b cell number	reduced number of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell
MP:0008171	abnormal mature B cell morphology	any structural anomaly of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex
MP:0008172	abnormal follicular B cell morphology	any structural anomaly of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes
MP:0008173	increased follicular B cell number	greater number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes
MP:0008174	decreased follicular B cell number	reduced number of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes
MP:0008175	absent follicular B cells	absence of resting mature B cells with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen and lymph nodes
MP:0008176	abnormal germinal center B cell morphology	any structural anomaly of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
MP:0008177	increased germinal center B cell number	greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
MP:0008178	decreased germinal center B cell number	reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
MP:0008179	absent germinal center B cells	absence of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen
MP:0008180	abnormal marginal zone B cell morphology	any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
MP:0008181	increased marginal zone B cell number	greater number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
MP:0008182	decreased marginal zone B cell number	reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
MP:0008183	absent marginal zone B cells	absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
MP:0008184	abnormal naive B cell morphology	any structural anomaly of a mature B cell which has not yet been activated by antigen
MP:0008185	decreased naive B cell number	reduced number of mature B cells which have not yet been activated by antigen
MP:0008186	increased pro-B cell number	greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
MP:0008187	absent pro-B cells	absence of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
MP:0008188	abnormal transitional stage B cell morphology	any structural anomaly of an immature B cell of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection
MP:0008189	increased transitional stage B cell number	greater number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection
MP:0008190	decreased transitional stage B cell number	reduced number of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection
MP:0008191	abnormal follicular B cell physiology	abnormal function of a resting mature B cell with distinct phenotypic characteristics (CD23-positive, CD21-positive) found typically in the B cell follicle region of the spleen
MP:0008192	abnormal germinal center B cell physiology	abnormal function of a rapidly cycling mature B cell which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes
MP:0008193	abnormal marginal zone B cell physiology	abnormal function of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL
MP:0008194	abnormal memory B cell physiology	abnormal function of a distinctly differentiated long-lived B cell that is readily activated upon reencounter of its antigenic determinant; memory B cells differentiate from antigen-activated B cells which have been selected for expression of higher affinity immunoglobulin
MP:0008195	abnormal professional antigen presenting cell morphology	any structural anomaly of a cell capable of processing and presenting lipid and protein antigens to T cells in order to initiate an immune response
MP:0008196	abnormal follicular dendritic cell morphology	any structural anomaly of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
MP:0008197	abnormal follicular dendritic cell physiology	abnormal function of a cell with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
MP:0008198	abnormal follicular dendritic cell antigen presentation	anomaly in the ability of follicular dendritic cells to process and present antigen to B lymphocytes
MP:0008199	increased follicular dendritic cell number	greater number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
MP:0008200	decreased follicular dendritic cell number	reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
MP:0008201	absent follicular dendritic cells	absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response
MP:0008202	absent B-1 B cells	absence of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and are enriched for self-reactivity; B-1 B cells are thought to be the primary source of natural IgM immunoglobulin, that is, IgM produced in large quantities without prior antigenic stimulation and generally reactive against various microorganisms, as well as the source of T-independent IgA immunoglobulin in the mucosal areas
MP:0008203	absent B-1a cells	absence of the B-1 B cell subset bearing the CD5 surface marker
MP:0008204	absent B-1b cells	absence of the B-1 B cell subset not bearing the CD5 surface marker, but having other phenotypic attributes of a B-1 B cell
MP:0008205	absent B-2 B cells	absence of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells
MP:0008206	increased B-2 B cell number	greater number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells
MP:0008207	decreased B-2 B cell number	reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells
MP:0008208	decreased pro-B cell number	reduced number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
MP:0008209	decreased pre-B cell number	reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface
MP:0008210	increased mature B cell number	greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex
MP:0008211	decreased mature B cell number	reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex
MP:0008212	absent mature B cells	absence of the mature form of a B cell, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex
MP:0008213	absent immature B cells	absence of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity
MP:0008214	increased immature B cell number	greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity
MP:0008215	decreased immature B cell number	reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity
MP:0008216	absent transitional stage B cells	absence of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection
MP:0008217	abnormal B cell activation	any anomaly in the normal change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific
MP:0008218	delayed emergence of vibrissae	eruption of the vibrissae from the skin later than expected
MP:0008219	abnormal dorsal telencephalic commissure morphology	any structural anomaly of the fiber tracts that connect the dorsal region of the two cerebral hemispheres and span the longitudinal fissure, including the corpus callosum and hippocampal commissure
MP:0008220	abnormal ventral commissure morphology	any structural anomaly of the fiber tracts that connect the ventral region of the two cerebral hemispheres and span the longitudinal fissure, including the anterior and the habenular commissures
MP:0008221	abnormal hippocampal commissure morphology	any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side
MP:0008222	decreased hippocampal commissure size	reduced size of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side
MP:0008223	absent hippocampal commissure	absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side
MP:0008224	increased hippocampal commissure size	enlarged triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side
MP:0008225	abnormal anterior commissure morphology	any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle
MP:0008226	decreased anterior commissure size	reduced size of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle
MP:0008227	absent anterior commissure	absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle
MP:0008228	increased anterior commissure size	enlarged round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle
MP:0008229	obsolete abnormal pars posterior morphology	OBSOLETE. any structural anomaly of the horseshoe-shaped tract that connects the two olfactory bulbs
MP:0008230	obsolete abnormal pars anterior morphology	OBSOLETE. any structural anomaly of the major forebrain commissure that connects the two temporal lobes of the cortex
MP:0008231	abnormal habenular commissure morphology	any structural anomaly of the connection between the right and left habenular nuclei; the decussation of fibers of the two striae medullares, forming the dorsal portion of the peduncle of the pineal body
MP:0008232	abnormal cingulum morphology	any structural anomaly of the white matter fiber bundle that projects from the cingulate gyrus to the entorhinal cortex in the brain
MP:0008233	abnormal pro-B cell differentiation	atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs
MP:0008234	absent spleen marginal zone	absence of the zone between the red and white pulp of the spleen containing numerous macrophages and lymphocytes, and a rich plexus of sinusoids supplied by white pulp arterioles carrying blood-borne antigens
MP:0008235	increased susceptibility to neuronal excitotoxicity	greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
MP:0008236	decreased susceptibility to neuronal excitotoxicity	less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kainate-induced neuronal cell death mediated via a glutamate excitotoxic process
MP:0008237	abnormal ventral coat pigmentation	irregular or unusual pigmentation of ventrum hair in relation to control animals
MP:0008238	abnormal dorsoventral coat patterning	irregular or unusual pigmentation pattern of the dorsal-to-ventral axis compared to control animals
MP:0008239	obsolete epigenetic coat coloration	OBSOLETE. a range of wild-type and mutant allele coat coloration, from mouse to mouse or coat color mosaicism of an individual mouse, due to differential methylation of the mutation causing element
MP:0008240	abnormal spleen marginal zone macrophage morphology	any structural anomaly of the cells present in the splenic marginal zone and are involved in the recognition and clearance of material, such as pathogen-derived material, from the splenic circulation
MP:0008241	abnormal metallophilic macrophage morphology	any structural anomaly of the macrophage cells that surround the white pulp of the spleen, adjacent to the marginal sinus
MP:0008242	abnormal perivascular macrophage morphology	any structural anomaly of macrophages that line the small blood vessels
MP:0008243	abnormal macrophage derived foam cell morphology	any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions
MP:0008244	abnormal peritoneal macrophage morphology	any structural anomaly of a mononuclear phagocyte that develops from bone marrow precursors but is resident in the peritoneum
MP:0008245	abnormal alveolar macrophage morphology	any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells
MP:0008246	abnormal leukocyte morphology	any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue
MP:0008247	abnormal mononuclear cell morphology	any structural anomaly of a leukocyte with a single non-segmented nucleus in the mature form
MP:0008248	abnormal mononuclear phagocyte morphology	any structural anomaly of a vertebrate phagocyte with a single nucleus
MP:0008249	abnormal common lymphocyte progenitor cell morphology	any structural anomaly of a progenitor cell committed to the lymphoid lineage
MP:0008250	abnormal myeloid leukocyte morphology	any structural anomaly of a cell of the monocyte, granulocyte, or mast cell lineage
MP:0008251	abnormal phagocyte morphology	any structural anomaly of cells capable of ingesting particulate matter via phagocytosis
MP:0008252	abnormal multinucleated phagocyte morphology	any structural anomaly of a phagocyte formed by the fusion of mononuclear phagocytes
MP:0008253	absent megakaryocytes	absence of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm
MP:0008254	increased megakaryocyte cell number	greater number of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm
MP:0008255	decreased megakaryocyte cell number	reduced number of the giant 50 to 100 micron diameter cells with greatly lobulated nuclei found in the bone marrow; mature blood platelets are released from their cytoplasm
MP:0008256	abnormal myometrium morphology	any structural anomaly of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium
MP:0008257	thin myometrium	reduced thickness of the smooth muscle coat of the uterus, which forms the main mass of the organ and surrounds and supports the endometrium
MP:0008258	thin endometrium	reduced thickness of the glandular mucous membrane lining of the uterine cavity that is hormonally responsive during the estrous/menstrual cycle and during pregnancy
MP:0008259	abnormal optic disk morphology	any structural anomaly of the area in the retina where all of the axons of the ganglion cells exit the retina to form the optic nerve
MP:0008260	abnormal autophagy	abnormal catabolic process involving the degradation of a cell's own components through the lysosomal machinery
MP:0008261	arrest of male meiosis	cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell
MP:0008262	abnormal hippocampus region morphology	any structural anomaly of a part or parts of the hippocampus that have a particular function
MP:0008263	abnormal hippocampus CA1 region morphology	any structural anomaly of a cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation consisting primarily of pyramidal neurons; the pyramidal neurons of CA1 receive projections from pyramidal neurons of CA3 via the Schaffer collaterals and send outputs to the entorhinal cortex and to the subiculum
MP:0008264	absent hippocampus CA1 region	missing the CA1 region of the hippocampus
MP:0008265	abnormal hippocampus CA2 region morphology	any structural anomaly of the smallest cytoarchitectural subregion of the Ammon's horn region of the hippocampal formation, located between CA3 and CA1, comprised of pyramidal neurons receiving both Schaffer collateral and mossy fiber input
MP:0008266	absent hippocampus CA2 region	missing the CA2 region of the hippocampus
MP:0008267	abnormal hippocampus CA3 region morphology	any structural anomaly in the region of the hippocampus proper bounded by the hilus of the dentate gyrus and area CA2, characterized by large pyramidal cells and a dense projection from dentate gyrus granule cell mossy fibers
MP:0008268	absent hippocampus CA3 region	missing the CA3 region of the hippocampus
MP:0008269	abnormal hippocampus CA4 region morphology	any structural anomaly of the region of the hippocampal formation that is comprised of mossy cells that primarily receive inputs from granule cells in the dentate gyrus in the form of mossy fibers and from pyramidal cells in CA3, and send outputs into the dentate gyrus
MP:0008270	absent hippocampus CA4 region	missing the CA4 region of the hippocampus
MP:0008271	abnormal bone ossification	any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance
MP:0008272	abnormal endochondral bone ossification	anomaly in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone
MP:0008273	abnormal intramembranous bone ossification	anomaly in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed
MP:0008274	failure of bone ossification	failure to initiate or a block in the process of the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance
MP:0008275	failure of endochondral bone ossification	failure to initiate or a block in the process of the formation of bone by the replacement of cartilage tissue with mineralized bone
MP:0008276	failure of intramembranous bone ossification	failure to initiate or a block in the process of the formation of bone in which osteoblasts secrete a collage-proteoglycan matrix that binds calcium salts and becomes calcified; intramembranous ossification is the way flat bones are formed
MP:0008277	abnormal sternum ossification	anomaly in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone
MP:0008278	failure of sternum ossification	failure to initiate or a block in the process of the formation of the sternum bone by the replacement of cartilage tissue with mineralized bone
MP:0008279	arrest of spermiogenesis	block in the process by which a spermatid transforms into a functional spermatozoon
MP:0008280	abnormal male germ cell apoptosis	change in the timing or the number of male germ cells undergoing programmed cell death
MP:0008281	abnormal hippocampus size	anomaly in the size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation
MP:0008282	enlarged hippocampus	increased size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation
MP:0008283	small hippocampus	reduced size of the deep lying structure of the cerebrum involved with memory storage and spatial navigation
MP:0008284	abnormal hippocampus pyramidal cell layer	any structural anomaly of the cytoarchitectural term denoting the layer of the hippocampus in which pyramidal cells are predominant. Its location is superficial to the Stratum oriens; it is deep to the Stratum radiatum in area CA1 and area CA2 and deep to the Stratum lucidum in area CA3
MP:0008285	abnormal hippocampus granule cell layer	any structural anomaly in the layer of the hippocampus composed primarily of granule cells
MP:0008286	abnormal hippocampus molecular cell layer	any structural anomaly of the cytoarchitectural region of the hippocampus consisting of a composite of the two outermost layers of the hippocampus, the Stratum lacunosum-moleculare and the Stratum radiatum
MP:0008287	abnormal subiculum morphology	any structural anomaly of the transitional zone between the parahippocampal gyrus and the Ammon gyrus
MP:0008288	abnormal adrenal cortex morphology	any structural anomaly of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone
MP:0008289	abnormal adrenal medulla morphology	any structural anomaly of the inner portion of the adrenal gland that consists mainly of chromaffin cells which produce, store and secrete neurotransmitters such as epinephrine and norepinephrine
MP:0008290	absent adrenal cortex	absence of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone
MP:0008291	abnormal adrenocortical cell morphology	any structural anomaly of the steroid hormone-producing cells of the cortex of the adrenal gland
MP:0008292	enlarged adrenocortical cell nuclei	nuclei of the cells of the cortex of the adrenal gland are larger than normal
MP:0008293	abnormal adrenal gland zona glomerulosa morphology	any structural anomaly of the narrow subcapsular outer zone of the adrenal cortex where aldosterone is produced
MP:0008294	abnormal adrenal gland zona fasciculata morphology	any structural anomaly of the wide middle zone of the adrenal cortex that produces cortisol (hydrocortisone)
MP:0008295	abnormal adrenal gland zona reticularis morphology	any structural anomaly of the inner zone of the adrenal cortex that produces the enzymes that convert pregnenolone, a 21-carbon steroid, to 19-carbon steroids
MP:0008296	abnormal adrenal gland x-zone morphology	any structural anomaly of the transient cortical layer juxtaposed to the medulla and the zona reticularis; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females
MP:0008297	retention of the adrenal gland x-zone	failure of the transient cortical layer juxtaposed to the medulla and the zona reticularis to degenerate after puberty in males or after pregnancy in females
MP:0008298	adrenergic chromaffin cell hyperplasia	an increase in the number of the cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine secretion
MP:0008299	adrenal cortical hyperplasia	increase in the number of normal cells in normal arrangement in the adrenal cortex, typically resulting in increased size
MP:0008300	enlarged adrenal medulla	increased size of the inner portion of the adrenal gland that consists mainly of chromaffin cells
MP:0008301	adrenal medulla hyperplasia	increase in the number of normal cells in normal arrangement in the adrenal medulla, typically resulting in increased size
MP:0008302	thin adrenal cortex	reduced thickness of the thick outer layer of the adrenal gland that produces and secretes steroid hormones such as corticosterone, estrone and aldosterone
MP:0008303	early degeneration of the adrenal gland x-zone	degeneration of the transient cortical layer juxtaposed to the medulla and the zona reticularis prior to the expected time; in males, this zone rapidly involutes at the onset of puberty whereas this zone persists in females until the first pregnancy or later in adulthood in non-pregnant females
MP:0008304	abnormal organ of Corti supporting cell differentiation	atypical production of or inability to produce the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti
MP:0008305	abnormal organ of Corti supporting cell physiology	any functional anomaly in processes pertinent to the integrated function of the highly differentiated epithelial cells with distinctive morphological features that surround the hair cells in the organ of Corti
MP:0008306	abnormal organ of Corti supporting cell proliferation	aberrant timing or any anomaly in the ability of supporting cells in the organ of Corti to undergo expansion by cell division
MP:0008307	short scala media	reduced length of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani
MP:0008308	small scala media	reduced size of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani
MP:0008309	dilated scala media	stretched or widened aperture of the luminal space of the spirally arranged membranous tube suspended within the cochlea, lying between and separating the scala vestibuli and scala tympani
MP:0008310	abnormal sympathetic preganglionic fiber morphology	any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a sympathetic ganglion
MP:0008311	abnormal parasympathetic preganglionic fiber morphology	any structural anomaly of any or all of the cholinergic axonal fibers projecting from the CNS to a parasympathetic ganglion
MP:0008312	abnormal sympathetic postganglionic fiber morphology	any structural anomaly of any or all of the noradrenergic and some adrenergic axonal fibers projecting from a sympathetic ganglion to an effector organ
MP:0008313	abnormal parasympathetic postganglionic fiber morphology	any structural anomaly of any or all of the cholinergic axonal fibers projecting from a parasympathetic ganglion to an effector organ
MP:0008314	abnormal pterygopalatine ganglion morphology	any structural anomaly of the small parasympathetic ganglion that supplies nerve fibers to the lacrimal, nasal, palatine and pharyngeal glands
MP:0008315	abnormal otic ganglion morphology	any structural anomaly of the ganglion that supplies nerve fibers to the parotid gland
MP:0008316	abnormal prevertebral ganglion morphology	any structural anomaly of the sympathetic ganglia located in front of the vertebral column and are associated with the major branches of the abdominal aorta; these include the celiac, aorticorenal, superior and inferior mesenteric ganglia
MP:0008317	abnormal paravertebral ganglion morphology	any structural anomaly of the groups of postsynaptic neurons located at intervals along the sympatheic trunk, including the superior cervical, middle cervical and stellate (cervicothoracic) ganglia as well as the thoracic, lumbar and sacral ganglia
MP:0008318	abnormal splanchnic nerve morphology	any structural anomaly of the major nerves supplying sympathetic innervation to the abdomen, including the greater, lesser, and lowest (or smallest) splanchnic nerves that are formed by preganglionic fibers from the spinal cord, which pass through the paravertebral ganglia and then to the celiac ganglia and plexuses, and the lumbar splanchnic nerves carry fibers which pass through the lumbar paravertebral ganglia to the mesenteric and hypogastric ganglia
MP:0008319	abnormal sympathetic afferent fiber morphology	any structural anomaly of the fibers that conduct sensory nerve impulses from the viscera through the posterior dorsal roots into the spinal cord
MP:0008320	absent adenohypophysis	absence of the anterior part of the pituitary that secretes a variety of hormones
MP:0008321	small adenohypophysis	reduced size of the anterior part of the pituitary that secretes a variety of hormones
MP:0008322	abnormal somatotroph morphology	any structural anomaly of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008323	abnormal lactotroph morphology	any structural anomaly of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008324	abnormal melanotroph morphology	any structural anomaly of a cell of the intermediate pituitary that produces melanocyte stimulating hormone and other peptides from the post-translational processing of pro-opiomelanocortin (POMC)
MP:0008325	abnormal gonadotroph morphology	any structural anomaly of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008326	abnormal thyrotroph morphology	any structural anomaly of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008327	abnormal corticotroph morphology	any structural anomaly of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008328	increased somatotroph cell number	greater number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008329	decreased somatotroph cell number	reduced number of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008330	absent somatotrophs	absence of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008331	increased lactotroph cell number	greater number of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008332	decreased lactotroph cell number	reduced number of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008333	absent lactotrophs	absence of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008334	increased gonadotroph cell number	greater number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008335	decreased gonadotroph cell number	reduced number of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008336	absent gonadotrophs	absence of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008337	increased thyrotroph cell number	greater number of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008338	decreased thyrotroph cell number	reduced number of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008339	absent thyrotrophs	absence of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008340	increased corticotroph cell number	greater number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008341	decreased corticotroph cell number	reduced number of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008342	absent corticotrophs	absence of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008343	abnormal gamma-delta T cell morphology	any structural anomaly of an immature or mature T cell expressing an gamma-delta T cell receptor complex
MP:0008344	abnormal mature gamma-delta T cell morphology	any structural anomaly of a mature T cell expressing an gamma-delta T cell receptor complex
MP:0008345	abnormal gamma-delta T cell number	anomaly in the number of immature or mature T cells expressing an gamma-delta T cell receptor complex
MP:0008346	increased gamma-delta T cell number	greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex
MP:0008347	decreased gamma-delta T cell number	reduced number of immature or mature T cells expressing an gamma-delta T cell receptor complex
MP:0008348	absent gamma-delta T cells	absence of immature or mature T cells expressing an gamma-delta T cell receptor complex
MP:0008349	abnormal gamma-delta intraepithelial T cell morphology	any structural anomaly of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008350	increased gamma-delta intraepithelial T cell number	greater number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008351	decreased gamma-delta intraepithelial T cell number	reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008352	absent gamma-delta intraepithelial T cell	absence of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008353	increased mature gamma-delta T cell number	increased number of a mature T cell expressing an gamma-delta T cell receptor complex
MP:0008354	decreased mature gamma-delta T cell number	reduced number of a mature T cell expressing an gamma-delta T cell receptor complex
MP:0008355	absent mature gamma-delta T cells	absence of a mature T cell expressing an gamma-delta T cell receptor complex
MP:0008356	abnormal gamma-delta T cell differentiation	atypical production of or inability to produce gamma-delta T cells, and/or accumulation of gamma-delta T cell precursors
MP:0008357	abnormal CD4-positive, gamma-delta intraepithelial T cell morphology	any structural anomaly of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008358	increased CD4-positive, gamma-delta intraepithelial T cell number	greater number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008359	decreased CD4-positive, gamma-delta intraepithelial T cell number	reduced number of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008360	absent CD4-positive, gamma-delta intraepithelial T cells	absence of a CD4-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008361	abnormal CD8-positive, gamma-delta intraepithelial T cell morphology	any structural anomaly of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008362	increased CD8-positive, gamma-delta intraepithelial T cell number	greater number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008363	decreased CD8-positive, gamma-delta intraepithelial T cell number	reduced number of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008364	absent CD8-positive, gamma-delta intraepithelial T cells	absence of a CD8-positive, gamma-delta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008365	adenohypophysis hypoplasia	decrease in the number of normal cells in normal arrangement in the adenohypophysis, typically resulting in decreased size
MP:0008366	enlarged adenohypophysis	increased size of the anterior part of the pituitary that secretes a variety of hormones
MP:0008367	absent pituitary intermediate lobe	absence of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults
MP:0008368	small pituitary intermediate lobe	reduced size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults
MP:0008369	pituitary intermediate lobe hypoplasia	decrease in the number of normal cells in normal arrangement in the pituitary intermediate lobe, typically resulting in decreased size
MP:0008370	enlarged pituitary intermediate lobe	increased size of the thin boundary between the adenohypophysis and neurohypophysis of the pituitary that produces melanocyte stimulating hormone (MSH); this area is small or absent in mammalian adults
MP:0008371	pituitary intermediate lobe hyperplasia	increase in the number of normal cells in normal arrangement in the pituitary intermediate lobe, typically resulting in increased size
MP:0008372	small malleus	reduced size of the largest of the three auditory ossicles, which resembles a club or hammer
MP:0008373	short malleus	reduced length of the largest of the three auditory ossicles, which resembles a club or hammer
MP:0008374	abnormal malleus manubrium morphology	any structural anomaly in the handle of the malleus, which extends downward, inward, and backward from the neck of the malleus and is embedded throughout its length in the tympanic membrane
MP:0008375	short malleus manubrium	reduced length of the handle of the malleus
MP:0008376	small malleus manubrium	reduced size of the handle of the malleus
MP:0008377	absent malleus manubrium	absence of the handle of the malleus
MP:0008378	small malleus processus brevis	reduced size of the projection extending from the base of the manubrium of the malleus which contacts the upper part of the tympanic membrane
MP:0008379	absent malleus head	absence of the rounded portion of the malleus articulating with the body of the incus
MP:0008380	abnormal gonial bone morphology	any structural anomaly of the investing bone that lies on the surface of the malleus
MP:0008381	absent gonial bone	absence of the investing bone that normally lies on the surface of the malleus
MP:0008382	gonial bone hypoplasia	decrease in the number of normal cells in normal arrangement in the gonial bone, typically resulting in decreased size
MP:0008383	enlarged gonial bone	increased size of the investing bone that lies on the surface of the malleus
MP:0008384	absent nasal capsule	absence of the cartilage around the developing nasal cavity of the embryo
MP:0008385	absent basisphenoid bone	absence of the part of the base of the cranium found between the basioccipital and the presphenoid bone
MP:0008386	absent styloid process	absence of the slender needle-like pointed projection that runs downward and slightly forward from the base of the inferior surface of the petrous portion of the temporal bone to join the tympanic portion
MP:0008387	hypochromic anemia	hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, resulting in insufficient oxygenation of tissues and organs
MP:0008388	hypochromic microcytic anemia	hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is smaller than normal
MP:0008389	hypochromic macrocytic anemia	hemoglobin deficiency resulting from a reduction in the concentration of hemoglobin in red cells, where the erythrocyte corpuscular volume is larger than normal
MP:0008390	abnormal primordial germ cell proliferation	anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division
MP:0008391	abnormal primordial germ cell morphology	any structural anomaly of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge
MP:0008392	decreased primordial germ cell number	reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge
MP:0008393	absent primordial germ cells	absence of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge
MP:0008394	increased primordial germ cell number	greater number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge
MP:0008395	abnormal osteoblast differentiation	atypical production of or inability to produce skeletogenic cells that secrete osteoid, are capable of producing mineralized (hydroxyapatite) matrix, are located adjacent to or within osteoid tissue, and arise from the transformation of a preosteoblast cell
MP:0008396	abnormal osteoclast differentiation	atypical production of or inability to produce the specialized phagocytic cells associated with the absorption and removal of the mineralized matrix of bone tissue
MP:0008397	abnormal CD4-positive, CD25-positive, alpha-beta regulatory T cell morphology	any structural anomaly of a CD4-positive, CD25-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
MP:0008398	abnormal CD8-positive, alpha-beta regulatory T cell morphology	any structural anomaly of a CD8-positive, alpha-beta T cell which regulates overall immune responses as well as the responses of other T cell subsets through direct cell-cell contact and cytokine release
MP:0008399	abnormal alpha-beta intraepithelial T cell morphology	any structural anomaly of an alpha-beta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008400	abnormal CD4-positive, alpha-beta intraepithelial T cell morphology	any structural anomaly of a CD4-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008401	abnormal CD8 positive, alpha-beta intraepithelial T cell morphology	any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements
MP:0008402	increased cellular sensitivity to alkylating agents	greater incidence of cell death following exposure to agents that cause DNA damage via the addition of alkyl groups to any or all of the bases of DNA
MP:0008403	decreased cellular sensitivity to alkylating agents	reduced incidence of cell death following exposure to agents that cause DNA damage via the addition of alkyl groups to any or all of the bases of DNA
MP:0008404	increased cellular sensitivity to methylmethanesulfonate	greater incidence of cell death following exposure to methylmethanesulfonate
MP:0008405	decreased cellular sensitivity to methylmethanesulfonate	reduced incidence of cell death following exposure to methylmethanesulfonate
MP:0008406	increased cellular sensitivity to hydrogen peroxide	greater incidence of cell death following exposure to hydrogen peroxide
MP:0008407	decreased cellular sensitivity to hydrogen peroxide	reduced incidence of cell death following exposure to hydrogen peroxide
MP:0008408	decreased cellular sensitivity to hydroxyurea	reduced incidence of cell death following exposure to hydroxyurea
MP:0008409	increased cellular sensitivity to hydroxyurea	greater incidence of cell death following exposure to hydroxyurea
MP:0008410	increased cellular sensitivity to ultraviolet irradiation	greater incidence of cell death following exposure to ultraviolet irradiation
MP:0008411	decreased cellular sensitivity to ultraviolet irradiation	reduced incidence of cell death following exposure to ultraviolet irradiation
MP:0008412	increased cellular sensitivity to oxidative stress	greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis
MP:0008413	decreased cellular sensitivity to oxidative stress	reduced incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis
MP:0008414	abnormal spatial reference memory	anomaly in the ability to recall spatial location information from previous encounters or training sessions in order to navigate or perform other behavior using such location cues
MP:0008415	abnormal neurite morphology	any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture
MP:0008416	increased somatotroph cell size	excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008417	decreased somatotroph cell size	reduced growth or small size of an acidophilic cell of the anterior pituitary that produces growth hormone, somatotropin
MP:0008418	abnormal cutaneous elastic fiber morphology	any structural anomaly of the slender connective tissue fiber in the extracellular matrix of skin tissue that is composed of microfibrils and amorphous elastin and is characterized by great elasticity
MP:0008419	abnormal cutaneous microfibril morphology	any structural anomaly of the fiber-like strand of fibrillin that forms the scaffold of the cutaneous elastic fibers found in the extracellular matrix of the skin
MP:0008420	increased thyrotroph cell size	excessive growth or enlargement of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008421	decreased thyrotroph cell size	reduced growth or small size of an anterior pituitary cell that produces thyroid-stimulating hormone
MP:0008422	increased lactotroph cell size	excessive growth or enlargement of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008423	decreased lactotroph cell size	reduced growth or small size of an acidophilic cell of the anterior pituitary that produces prolactin
MP:0008424	increased gonadotroph cell size	excessive growth or enlargement of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008425	decreased gonadotroph cell size	reduced growth or small size of the anterior pituitary cells that can produce both follicle stimulating hormone (FSH) and luteinizing hormone (LH)
MP:0008426	increased corticotroph cell size	excessive growth or enlargement of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008427	decreased corticotroph cell size	reduced growth or small size of an anterior pituitary basophilic cell that produces adrenocorticotrophic hormone (ACTH)
MP:0008428	abnormal spatial working memory	anomaly in the ability to spontaneously process spatial location information in order to navigate or perform other behavior using such location cues, without previous encounters or training at that location
MP:0008429	absent parotid gland	absence of the largest of the major salivary glands situated below and in front of each ear
MP:0008430	short temporal bone squamous part	length reduction of the anterosuperior portion of the temporal bone that is thin, scale-like, and translucent and forms part of the lateral wall of the cranial vault
MP:0008431	abnormal short-term spatial reference memory	anomaly in the short-term memory for spatial location information that is established during the first few minutes after training or an encounter at that location
MP:0008432	abnormal long-term spatial reference memory	anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location
MP:0008433	abnormal somatotroph cell nucleus	any structural anomaly of a somatotroph cell nucleus
MP:0008434	small somatotroph cell nucleus	decreased size of a somatotroph cell nucleus
MP:0008435	large somatotroph cell nucleus	increased size of a somatotroph cell nucleus
MP:0008436	decreased somatotroph secretory granule number	decreased number of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface
MP:0008437	absent somatotroph secretory granules	absence of vesicles derived from the golgi that contain somatotropin growth hormone to be released at the cell surface
MP:0008438	abnormal cutaneous collagen fibril morphology	any structural anomaly of the connective tissue bundles in the extracellular matrix of skin tissue that are composed of collagen, and play a role in skin strength and elasticity
MP:0008439	abnormal cortical plate morphology	any structural anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers
MP:0008440	abnormal subplate morphology	any structural anomaly of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate
MP:0008441	thin cortical plate	reduced thickness of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers
MP:0008442	disorganized cortical plate	derangement of the patterned arrangement of the cortical plate
MP:0008443	absent subplate	absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate
MP:0008444	retina cone cell degeneration	a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment
MP:0008445	increased retina cone cell number	greater number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment
MP:0008446	decreased retina cone cell number	reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment
MP:0008447	absent retina cone cells	absence of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment
MP:0008448	abnormal retina cone cell inner segment morphology	any structural anomaly of the retinal cone cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0008449	abnormal retina cone cell outer segment morphology	any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane
MP:0008450	retina photoreceptor degeneration	a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina
MP:0008451	retina rod cell degeneration	a retrogressive impairment of function or destruction of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane
MP:0008452	increased retina rod cell number	greater number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane
MP:0008453	decreased retina rod cell number	reduced number of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane
MP:0008454	absent retina rod cells	absence of one of the photoreceptor cell types of the vertebrate retina, in which the photopigment is in stacks of membranous disks separate from the outer cell membrane
MP:0008455	abnormal retina rod cell inner segment morphology	any structural anomaly of the retinal rod cell region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0008456	abnormal retina rod cell outer segment morphology	any structural anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin
MP:0008457	abnormal cortical intermediate zone morphology	any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone
MP:0008458	abnormal cortical ventricular zone morphology	any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons
MP:0008459	abnormal circulating pancreatic peptide level	anomaly in the amount of the 36-amino acid pancreatic hormone in the blood that is secreted mainly by endocrine cells found at the periphery of the islets of Langerhans in response to ingestions, and regulates gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite
MP:0008460	absent dorsal root ganglion	absence of the groups of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column
MP:0008461	left atrial isomerism	anomaly in the asymmetry of the cardiac atria such that atria on both the left and right side have the morphology normally seen on the left side of the body
MP:0008462	abnormal medium spiny neuron morphology	any structural anomaly of the inhibitory projection neurons located in the striatum that integrate glutamatergic signals arising from the cerebral cortex and thalamus
MP:0008463	abnormal peripheral lymph node morphology	any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes
MP:0008464	absent peripheral lymph nodes	absence of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes
MP:0008465	absent mesenteric lymph nodes	absence of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group
MP:0008466	enlarged mesenteric lymph nodes	increased size of the lymph nodes located in the mesentery, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group
MP:0008467	absent proprioceptive neurons	absence of the sensory neurons of the dorsal root ganglia that sense body position and send information about how much the muscle is stretched to the spinal cord
MP:0008468	absent muscle spindles	absence of the sensory organs in muscle that are involved in the stretch reflex
MP:0008469	abnormal protein level	anomaly in the amount of any of the macromolecules consisting of long chains of amino acids in peptide linkage
MP:0008470	abnormal spleen B cell follicle morphology	any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur
MP:0008471	abnormal spleen primary B follicle morphology	any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp
MP:0008472	abnormal spleen secondary B follicle morphology	any structural anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp
MP:0008473	abnormal spleen follicular dendritic cell network	any structural anomaly of the enmeshed group of antigen presenting cells with extensive dendritic processes in the spleen B cell follicle that present antigen to B cells during an immune response
MP:0008474	absent spleen germinal center	absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0008475	intermingled spleen red and white pulp	no clear demarcation of the spleen red and white pulp tissue
MP:0008476	increased spleen red pulp amount	increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation
MP:0008477	decreased spleen red pulp amount	reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation
MP:0008478	increased spleen white pulp amount	increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
MP:0008479	decreased spleen white pulp amount	reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies
MP:0008480	absent eye pigmentation	absence of melanin (pigment) in the eye either due to absent melanocytes or failure of melanin synthesis
MP:0008481	increased spleen germinal center number	greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0008482	decreased spleen germinal center number	reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0008483	increased spleen germinal center size	greater size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0008484	decreased spleen germinal center size	reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs
MP:0008485	increased muscle spindle number	greater number of the sensory organs in muscle that are involved in the stretch reflex
MP:0008486	decreased muscle spindle number	reduced number of the sensory organs in muscle that are involved in the stretch reflex
MP:0008487	abnormal mesonephros morphology	any structural anomaly of the excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop
MP:0008488	abnormal semicircular canal ampulla morphology	any structural anomaly of the spherical enlargement at the base of each semicircular canal where they connect with the utricle, containing the crista ampullaris which detects movement of the fluid within the canals
MP:0008489	slow postnatal weight gain	the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults
MP:0008490	enlarged dorsal root ganglion	increased size a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column
MP:0008491	dorsal root ganglion hyperplasia	increase in the number of normal cells in normal arrangement in the dorsal root ganglion, typically resulting in increased size
MP:0008492	dorsal root ganglion degeneration	retrogressive pathological change of a group of sensory nerve cell bodies located on the dorsal spinal roots within the vertebral column
MP:0008493	alpha-synuclein inclusion body	formation of aggregates of the alpha-synuclein protein in neural and glial tissue; often seen in neurodegenerative disorders such as Parkinson's disease
MP:0008494	absence of all nails	absence of all of the horny plates covering the dorsal surface of the distal end of each terminal phalanx of the digits
MP:0008495	decreased IgG1 level	less than normal immunoglobulin class G1 level
MP:0008496	decreased IgG2a level	less than normal immunoglobulin class G2a level
MP:0008497	decreased IgG2b level	less than normal immunoglobulin class G2b level
MP:0008498	decreased IgG3 level	less than normal immunoglobulin class G3 level
MP:0008499	increased IgG1 level	greater than normal immunoglobulin class G1 level
MP:0008500	increased IgG2a level	greater than normal immunoglobulin class G2a level
MP:0008501	increased IgG2b level	greater than normal immunoglobulin class G2b level
MP:0008502	increased IgG3 level	greater than normal immunoglobulin class G3 level
MP:0008503	abnormal spinal cord grey matter morphology	any structural anomaly of the ridge-shaped grey matter of the spinal cord that extends longitudinally through the center of each half of the spinal cord, and are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue
MP:0008504	abnormal adrenal chromaffin cell morphology	any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion
MP:0008505	absent adrenal chromaffin cells	absence of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for epinephrine and norepinephrine secretion
MP:0008506	abnormal noradrenergic chromaffin cell morphology	any structural anomaly of the neuroendocrine cells of the medulla of the adrenal gland that are innervated by the splanchnic nerve and that are responsible for norepinephrine secretion
MP:0008507	thin retina ganglion layer	reduced thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain
MP:0008508	thick retina ganglion layer	increased thickness of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain
MP:0008509	disorganized retina ganglion layer	derangement of the pattern of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain
MP:0008510	absent retina ganglion layer	absence of the innermost nuclear layer of the retina, which contains neurons that project axons through the optic nerve to the brain
MP:0008511	thin retina inner nuclear layer	reduced thickness of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells
MP:0008512	disorganized retina inner nuclear layer	derangement of the normal pattern of the retinal layer that contains the cell bodies of bipolar, horizontal, and amacrine cells
MP:0008513	thin retina inner plexiform layer	reduced thickness of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites
MP:0008514	absent retina inner plexiform layer	absence of the retinal cell layer where bipolar and amacrine cell axons synapse with ganglion cell dendrites
MP:0008515	thin retina outer nuclear layer	reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones
MP:0008516	disorganized retina outer nuclear layer	derangement of the normal pattern of the retinal layer that contains the nuclei and cell bodies of rods and cones
MP:0008517	thick retina outer nuclear layer	increased thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones
MP:0008518	retina outer nuclear layer degeneration	a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones
MP:0008519	thin retina outer plexiform layer	reduced thickness of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)
MP:0008520	disorganized retina outer plexiform layer	a derangement of the normal pattern of the retinal layer that is the site of synapses between the rods and cones (axons) and the horizontal and bipolar cells (dendrites)
MP:0008521	abnormal Bowman membrane morphology	any structural anomaly of the layer of acellular matrix that lies beneath the corneal epithelium and above the corneal stroma, consists of randomly arranged collagen fibers in a condensed bed of intercellular substance, and provides stability and strength to the cornea
MP:0008522	abnormal lymph node germinal center morphology	any structural anomaly of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells
MP:0008523	absent lymph node germinal center	absence of the area of the lymph node secondary follicle where antigen-activated B-cell blasts are stimulated by antigens and proliferate, with the immunoglobulin genes undergoing somatic hypermutation, before the cells migrate away as plasma cells or memory cells
MP:0008524	increased plasmacytoid dendritic cell number	greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli
MP:0008525	decreased cranium height	decrease in the rostral-caudal distance between the cranial base and the upper domelike portion of the skull
MP:0008526	decreased cranium width	having a decreased side-to-side, or lateral distance of the cranium
MP:0008527	embryonic lethality at implantation	death due to failure of implantation (Mus: E4.5)
MP:0008528	polycystic kidney	presence of multiple fluid-filled cysts in one or both kidneys
MP:0008529	enlarged optic nerve	increased size of the second cranial nerve which is responsible for conveying visual information from the retina to the brain; it extends from the retina to the optic chiasma where part of its fibers become the optic tract and cross to the opposite side and pass to the geniculate bodies
MP:0008530	abnormal rostral-caudal patterning of the somites	anomaly in the developmental pattern of the somites along the axis that runs from the rostral to the caudal region of the body
MP:0008531	increased chemical nociceptive threshold	a greater than average concentration at which chemically induced pain sensation is first detectable
MP:0008532	decreased chemical nociceptive threshold	a lower than average concentration at which chemically induced pain sensation is first detectable
MP:0008533	abnormal anterior visceral endoderm morphology	any structural anomaly of the extraembryonic tissue that is responsible for the proper orientation of the anterior-posterior axis of the embryo and for appropriate patterning of adjacent embryonic tissue
MP:0008534	enlarged fourth ventricle	increased size of the irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space
MP:0008535	enlarged lateral ventricles	increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle
MP:0008536	enlarged third ventricle	increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina
MP:0008537	increased susceptibility to induced colitis	increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)
MP:0008538	decreased zigzag hair amount	reduced number of the truncal hairs that have two or more sharp bends with diameter constrictions at the bends, and contain one air cell in the medulla
MP:0008539	decreased susceptibility to induced colitis	decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)
MP:0008540	abnormal cerebral hemisphere morphology	any structural anomaly of the largest part of the brain; the cerebrum is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities
MP:0008541	leukostasis	abnormal intravascular leukocyte aggregation and clumping most commonly seen in the brain and lungs of organisms with leukemia, often with an excess of leukocytes in the blood
MP:0008542	enlarged cervical lymph nodes	increased size of the lymph nodes found near the neck and shoulders
MP:0008543	atrial fibrillation	asynchronous contraction or quivering of individual cardiac muscle fibers in the atria
MP:0008544	impaired olfaction	reduced ability to detect odors
MP:0008545	absent sperm flagellum	absence of the whiplike posterior filiform portion of the spermatozoon that provides sperm motility
MP:0008546	abnormal vesicle-mediated transport	anomaly in the directed movement of substances, either within a vesicle or in the vesicle membrane, into, out of or within a cell
MP:0008547	abnormal neocortex morphology	any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers
MP:0008548	abnormal circulating interferon level	anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions
MP:0008549	abnormal circulating interferon-alpha level	anomaly in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008550	abnormal circulating interferon-beta level	anomaly in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008551	abnormal circulating interferon-gamma level	anomaly in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008552	abnormal circulating tumor necrosis factor level	anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008553	increased circulating tumor necrosis factor level	greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008554	decreased circulating tumor necrosis factor level	reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008555	abnormal interferon secretion	anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions
MP:0008556	abnormal tumor necrosis factor secretion	anomaly in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008557	abnormal interferon-alpha secretion	anomaly in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008558	abnormal interferon-beta secretion	anomaly in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008559	abnormal interferon-gamma secretion	anomaly in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008560	increased tumor necrosis factor secretion	increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008561	decreased tumor necrosis factor secretion	reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium
MP:0008562	increased interferon-alpha secretion	increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008563	decreased interferon-alpha secretion	decrease in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008564	increased interferon-beta secretion	increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008565	decreased interferon-beta secretion	reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008566	increased interferon-gamma secretion	increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008567	decreased interferon-gamma secretion	reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008568	abnormal interleukin secretion	anomaly in the production or cellular release of soluble factors which stimulate growth-related activities of leukocytes and other cell types, that can act to enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli
MP:0008569	lethality at weaning	premature death at weaning age, often due to the inability to make the transition to solid food
MP:0008570	lipidosis	abnormal fat metabolism with increased accumulation of specific lipids in tissue
MP:0008571	abnormal synaptic bouton morphology	any structural anomaly of the knoblike enlargements along the course of axons, or more commonly at the distal terminations of axons which are specialized for the release of neurotransmitters
MP:0008572	abnormal Purkinje cell dendrite morphology	any structural anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer
MP:0008573	increased circulating interferon-alpha level	increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008574	decreased circulating interferon-alpha level	reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells
MP:0008575	increased circulating interferon-beta level	increase in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008576	decreased circulating interferon-beta level	reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity
MP:0008577	increased circulating interferon-gamma level	increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008578	decreased circulating interferon-gamma level	reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation
MP:0008579	abnormal Purkinje cell differentiation	atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex
MP:0008580	photoreceptor inner segment degeneration	retrogressive pathologic change in the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0008581	disorganized photoreceptor inner segment	derangement of the pattern of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0008582	short photoreceptor inner segment	decreased length of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be part of the outer segment region
MP:0008583	absent photoreceptor inner segment	absence of the photoreceptor region which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc) and where opsin molecules are assembled and passed to be