|
Symbol Name ID |
Runx2
runt related transcription factor 2 MGI:99829 |
| Darker colors indicate more annotations |
| Human Phenotypes | Frontal bossing |
Parietal bossing |
Brachycephaly |
Thickened calvaria |
Micrognathia |
Mandibular prognathia |
Hypoplasia of the maxilla |
Absent frontal sinuses |
Hypoplastic frontal sinuses |
Absent paranasal sinuses |
Sinusitis |
Hypoplasia of the zygomatic bone |
Malar flattening |
Large foramen magnum |
Decreased skull ossification |
Macrocephaly |
Persistent open anterior fontanelle |
Wormian bones |
Large fontanelles |
Short face |
Midface retrusion |
Dimple chin |
Broad forehead |
Sloping forehead |
Short philtrum |
Thin vermilion border |
Cleft palate |
High palate |
High, narrow palate |
Narrow palate |
Glossoptosis |
Abnormality of the dentition |
Supernumerary tooth |
Delayed eruption of teeth |
Delayed eruption of permanent teeth |
Delayed eruption of primary teeth |
Abnormal dental enamel morphology |
Enamel hypoplasia |
Carious teeth |
Premature loss of teeth |
Open bite |
Convex nasal ridge |
Depressed nasal bridge |
Wide nasal bridge |
| Disease(s) Associated with RUNX2 | ||||||||||||||||||||||||||||||||||||||||||||
| cleidocranial dysplasia | ||||||||||||||||||||||||||||||||||||||||||||
| metaphyseal dysplasia-maxillary hypoplasia-brachydactyly syndrome |
| Mouse Phenotypes | abnormal craniofacial bone morphology |
abnormal cranial suture morphology |
wide cranial sutures |
abnormal cranium morphology |
small basisphenoid bone |
abnormal neurocranium morphology |
abnormal fontanelle morphology |
large anterior fontanelle |
abnormal interparietal bone morphology |
interparietal bone hypoplasia |
abnormal supraoccipital bone morphology |
absent occipital bone |
abnormal parietal bone morphology |
parietal bone hypoplasia |
absent zygomatic arch |
abnormal hyoid bone morphology |
hyoid bone hypoplasia |
abnormal incisor morphology |
small incisors |
abnormal molar morphology |
small molars |
abnormal tooth development |
abnormal dental lamina morphology |
abnormal dental papilla morphology |
abnormal cervical loop morphology |
abnormal enamel knot morphology |
arrest of tooth development |
growth retardation of incisors |
growth retardation of molars |
abnormal dentin morphology |
abnormal enamel morphology |
abnormal nasal bone morphology |
nasal bone hypoplasia |
abnormal zygomatic bone morphology |
palatal shelves fail to meet at midline |
cleft secondary palate |
abnormal nose morphology |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||
| Runx2tm1Gss/Runx2tm1Gss | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Hkiy/Runx2tm1Hkiy | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Jals/Runx2tm1Jals | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Kish/Runx2tm1Kish | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Ldq/Runx2tm1Ldq | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Mjo/Runx2tm1Mjo | ||||||||||||||||||||||||||||||||||||||
| Runx2em1(IMPC)Rbrc/Runx2+ | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Gss/Runx2+ | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Kish/Runx2+ | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Mjo/Runx2+ | ||||||||||||||||||||||||||||||||||||||
| Runx2tm1Javed/Runx2tm1Javed Tg(Col2a1-cre)1Bhr/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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