Symbol
Name
ID

Gja1
gap junction protein, alpha 1
MGI:95713

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Abnormality of chromosome segregation
Disease(s) Associated with GJA1	Abnormality of chromosome segregation
hypoplastic left heart syndrome

Mouse Phenotypes

abnormal vascular smooth muscle cell proliferation

azoospermia

decreased spermatid number

abnormal spermatocyte morphology

decreased spermatogonia number

decreased male germ cell number

decreased germ cell number

abnormal radial glial cell morphology

abnormal cell physiology

increased granulosa cell apoptosis

abnormal osteoblast differentiation

decreased granulosa cell proliferation

increased osteoblast proliferation

abnormal glial cell physiology

abnormal osteoblast physiology

Availability

Mouse Genotype

Gja1^em1Ipche/Gja1^em1Ipche

Gja1^tm1Kdr/Gja1^tm1Kdr

Gja1^tm3.1Clo/Gja1^tm3.1Clo

Gja1^tm7(Gja2)Kwi/Gja1^tm7(Gja2)Kwi

Gja1^M1Jrt/Gja1⁺

Tg(CMV-Gja1)BClo/0

Gja1^tm1Dlg/Gja1^tm1Dlg
Tg(GFAP-cre)1Kdmc/0 (conditional)

Gja1^tm1Kwi/Gja1^tm1Kwi
Plekha5^{Tg(AMH-cre)1Flor}/Plekha5⁺ (conditional)

Gja1^tm1Kwi/Gja1^tm1Kwi
Tg(S100b-cre)20Ito/0 (conditional)

Gja1^tm8Kwi/Gja1⁺
Tg(Pgk1-cre)1Lni/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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