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Symbol
Name
ID
Gba
glucosidase, beta, acid
MGI:95665
Phenotype annotations related to immune system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating antibody level
Leukopenia
Bacterial endocarditis
Abnormality of the spleen
Splenomegaly
Hepatosplenomegaly
Hypersplenism
Hepatitis
Osteomyelitis
Recurrent aspiration pneumonia
Recurrent respiratory infections
Bronchiolitis
Disease(s) Associated with GBA1
Gaucher's disease
Gaucher's disease perinatal lethal
Gaucher's disease type I
Gaucher's disease type II
Gaucher's disease type III
Gaucher's disease type IIIC

Mouse Phenotypes
abnormal Kupffer cell morphology
abnormal thymus morphology
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal T cell differentiation
decreased double-positive T cell number
decreased leukocyte cell number
abnormal macrophage morphology
abnormal microglial cell morphology
abnormal spleen morphology
intermingled spleen red and white pulp
increased IgG level
abnormal circulating cytokine level
abnormal circulating chemokine level
increased circulating interferon-gamma level
decreased circulating interleukin-1 alpha level
decreased circulating interleukin-1 beta level
increased circulating interleukin-10 level
increased circulating interleukin-13 level
increased circulating interleukin-2 level
increased circulating interleukin-3 level
decreased circulating interleukin-6 level
increased circulating interleukin-9 level
decreased circulating tumor necrosis factor level
abnormal immune system organ morphology
abnormal lymph node morphology
abnormal spleen physiology
lymph node inflammation
abnormal inflammatory response
liver inflammation
lung inflammation
skin inflammation
abnormal response to transplant
Availability Mouse Genotype
Gbatm1Nsb/Gbatm1Nsb
Gbatm1Rlp/Gbatm1Rlp
Gbatm2Ggb/Gbatm2Ggb
Gbatm3Ggb/Gbatm3Ggb
Gbatm4Ggb/Gbatm4Ggb
Gbatm2Ggb/Gbatm1Nsb
Gbatm3Ggb/Gbatm1Nsb
Gbatm4Ggb/Gbatm1Nsb
Gbatm1.1Pmis/Gbatm1.1Pmis
Tg(Mx1-cre)1Cgn/0  (conditional)
Gbatm1Karl/Gbatm1Karl
Tg(Nes-cre)1Kln/?  (conditional)
Gbatm2Karl/Gbatm2Karl
Tg(KRT14-cre)8Brn/?  (conditional)
Gbatm1.1Pmis/Gbatm1.2Pmis
Tg(Mx1-cre)1Cgn/0  (conditional)
Gbatm1Clk/Gbatm1.1Clk
Tg(Tek-cre)12Flv/0  (conditional)
Gbatm1Karl/Gbatm1.1Karl
Tg(Mx1-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/31/2023
MGI 6.22
The Jackson Laboratory