|
Symbol Name ID |
Gba
glucosidase, beta, acid MGI:95665 |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased circulating antibody level |
Leukopenia |
Bacterial endocarditis |
Abnormality of the spleen |
Splenomegaly |
Hepatosplenomegaly |
Hypersplenism |
Hepatitis |
Osteomyelitis |
Recurrent aspiration pneumonia |
Recurrent respiratory infections |
Bronchiolitis |
| Disease(s) Associated with GBA1 | ||||||||||||
| Gaucher's disease | ||||||||||||
| Gaucher's disease perinatal lethal | ||||||||||||
| Gaucher's disease type I | ||||||||||||
| Gaucher's disease type II | ||||||||||||
| Gaucher's disease type III | ||||||||||||
| Gaucher's disease type IIIC |
| Mouse Phenotypes | abnormal Kupffer cell morphology |
abnormal thymus morphology |
enlarged spleen |
increased spleen weight |
spleen hyperplasia |
abnormal T cell differentiation |
decreased double-positive T cell number |
decreased leukocyte cell number |
abnormal macrophage morphology |
abnormal microglial cell morphology |
abnormal spleen morphology |
intermingled spleen red and white pulp |
increased IgG level |
abnormal circulating cytokine level |
abnormal circulating chemokine level |
increased circulating interferon-gamma level |
decreased circulating interleukin-1 alpha level |
decreased circulating interleukin-1 beta level |
increased circulating interleukin-10 level |
increased circulating interleukin-13 level |
increased circulating interleukin-2 level |
increased circulating interleukin-3 level |
decreased circulating interleukin-6 level |
increased circulating interleukin-9 level |
decreased circulating tumor necrosis factor level |
abnormal immune system organ morphology |
abnormal lymph node morphology |
abnormal spleen physiology |
lymph node inflammation |
abnormal inflammatory response |
liver inflammation |
lung inflammation |
skin inflammation |
abnormal response to transplant |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||
| Gbatm1Nsb/Gbatm1Nsb | |||||||||||||||||||||||||||||||||||
| Gbatm1Rlp/Gbatm1Rlp | |||||||||||||||||||||||||||||||||||
| Gbatm2Ggb/Gbatm2Ggb | |||||||||||||||||||||||||||||||||||
| Gbatm3Ggb/Gbatm3Ggb | |||||||||||||||||||||||||||||||||||
| Gbatm4Ggb/Gbatm4Ggb | |||||||||||||||||||||||||||||||||||
| Gbatm2Ggb/Gbatm1Nsb | |||||||||||||||||||||||||||||||||||
| Gbatm3Ggb/Gbatm1Nsb | |||||||||||||||||||||||||||||||||||
| Gbatm4Ggb/Gbatm1Nsb | |||||||||||||||||||||||||||||||||||
| Gbatm1.1Pmis/Gbatm1.1Pmis Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||
| Gbatm1Karl/Gbatm1Karl Tg(Nes-cre)1Kln/? (conditional) |
|||||||||||||||||||||||||||||||||||
| Gbatm2Karl/Gbatm2Karl Tg(KRT14-cre)8Brn/? (conditional) |
|||||||||||||||||||||||||||||||||||
| Gbatm1.1Pmis/Gbatm1.2Pmis Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||
| Gbatm1Clk/Gbatm1.1Clk Tg(Tek-cre)12Flv/0 (conditional) |
|||||||||||||||||||||||||||||||||||
| Gbatm1Karl/Gbatm1.1Karl Tg(Mx1-cre)1Cgn/0 (conditional) |
|||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support. |
last database update 03/14/2023 MGI 6.22 |
|
|
|
||
Analysis Tools