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Symbol
Name
ID
Gba
glucosidase, beta, acid
MGI:95665
Phenotype annotations related to hematopoietic system
Darker colors indicate more annotations
Human Phenotypes
Increased circulating antibody level
Abnormal bleeding
Epistaxis
Spontaneous, recurrent epistaxis
Gingival bleeding
Intracranial hemorrhage
Bruising susceptibility
Purpura
Ecchymosis
Petechiae
Anemia
Leukopenia
Pancytopenia
Thrombocytopenia
Multiple myeloma
Abnormality of the spleen
Splenomegaly
Hepatosplenomegaly
Hypersplenism
Disease(s) Associated with GBA1
Gaucher's disease
Gaucher's disease perinatal lethal
Gaucher's disease type I
Gaucher's disease type II
Gaucher's disease type III
Gaucher's disease type IIIC

Mouse Phenotypes
abnormal Kupffer cell morphology
abnormal thymus morphology
enlarged spleen
increased spleen weight
spleen hyperplasia
abnormal T cell differentiation
decreased double-positive T cell number
extramedullary hematopoiesis
anemia
decreased erythrocyte cell number
decreased hematocrit
decreased hemoglobin content
decreased mean corpuscular volume
decreased leukocyte cell number
abnormal macrophage morphology
abnormal microglial cell morphology
abnormal spleen morphology
intermingled spleen red and white pulp
increased IgG level
Availability Mouse Genotype
Gbatm1Nsb/Gbatm1Nsb
Gbatm1Rlp/Gbatm1Rlp
Gbatm2Ggb/Gbatm2Ggb
Gbatm3Ggb/Gbatm3Ggb
Gbatm4Ggb/Gbatm4Ggb
Gbatm2Ggb/Gbatm1Nsb
Gbatm3Ggb/Gbatm1Nsb
Gbatm4Ggb/Gbatm1Nsb
Gbatm1.1Pmis/Gbatm1.1Pmis
Tg(Mx1-cre)1Cgn/0  (conditional)
Gbatm1Karl/Gbatm1Karl
Tg(Nes-cre)1Kln/?  (conditional)
Gbatm2Karl/Gbatm2Karl
Tg(KRT14-cre)8Brn/?  (conditional)
Gbatm1.1Pmis/Gbatm1.2Pmis
Tg(Mx1-cre)1Cgn/0  (conditional)
Gbatm1Clk/Gbatm1.1Clk
Tg(Tek-cre)12Flv/0  (conditional)
Gbatm1Karl/Gbatm1.1Karl
Tg(Mx1-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory