Symbol
Name
ID

En2
engrailed 2
MGI:95390

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	EEG abnormality	Delayed speech and language development	Abnormal nonverbal communicative behavior	Lack of spontaneous play	Reduced ability to form peer relationships	Autism	Motor stereotypy	Inflexible adherence to routines	Restrictive behavior	Intellectual disability	Seizure
Disease(s) Associated with EN2
autistic disorder

Mouse Phenotypes

nervous system phenotype

abnormal cerebellum development

abnormal cerebellar foliation

thin external granule cell layer

decreased inferior colliculus size

decreased colliculi size

abnormal cerebellum morphology

abnormal cerebellum hemisphere lobule morphology

abnormal cerebellar granule layer morphology

abnormal cerebellum vermis lobule morphology

abnormal cerebellum posterior vermis morphology

abnormal cerebellum vermis morphology

small cerebellum

Availability

Mouse Genotype

En2^tm1Alj/En2^tm1Alj

En2^tm2Alj/En2^tm2Alj

En2^tm3.1Alj/En2^tm3.1Alj

En2^tm3Alj/En2^tm3Alj

En2^tm5.1Alj/En2^tm5.1Alj

En2^tm2Alj/En2^tm3Alj

En2^tm5.1Alj/En2^tm5.1Alj
Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ (conditional)

En2^tm1Alj/En2^tm6Alj
Gt(ROSA)26Sor^{tm1(cre/ERT2)Alj}/Gt(ROSA)26Sor⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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