About Help FAQ

Symbol
Name
ID

Tcof1
treacle ribosome biogenesis factor 1
MGI:892003

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Micrognathia	Malar flattening
Disease(s) Associated with TCOF1	Micrognathia	Malar flattening
Treacher Collins syndrome 1

Mouse Phenotypes

skeleton phenotype

abnormal craniofacial bone morphology

abnormal cranium morphology

abnormal neurocranium morphology

abnormal frontal bone morphology

absent frontal bone

frontal bone hypoplasia

absent interparietal bone

absent parietal bone

abnormal temporal bone morphology

temporal bone hypoplasia

abnormal zygomatic arch morphology

zygomatic arch hypoplasia

small orbits

abnormal viscerocranium morphology

small mandible

mandible hypoplasia

short mandible

abnormal maxilla morphology

abnormal premaxilla morphology

premaxilla hypoplasia

short premaxilla

maxilla hypoplasia

short maxilla

retrognathia

abnormal nasal bone morphology

nasal bone hypoplasia

abnormal palatine bone morphology

palatine bone hypoplasia

absent turbinates

facial bone hypoplasia

acrania

domed cranium

abnormal middle ear ossicle morphology

middle ear ossicle hypoplasia

abnormal nasal capsule morphology

rib fusion

vertebral fusion

delayed endochondral bone ossification

Availability

Mouse Genotype

Tcof1^tm1Mjd/Tcof1⁺

*!

!

!

!

!

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23