Symbol
Name
ID

Rrm2b
ribonucleotide reductase M2 B (TP53 inducible)
MGI:2155865

Phenotype annotations related to renal/urinary system

Darker colors indicate more annotations

Human Phenotypes	Aminoaciduria	Proximal tubulopathy
Disease(s) Associated with RRM2B	Aminoaciduria	Proximal tubulopathy
mitochondrial DNA depletion syndrome 8a

Mouse Phenotypes

abnormal glomerular capillary endothelium morphology

abnormal glomerular endothelium fenestra morphology

abnormal glomerular capillary morphology

decreased glomerular capillary number

increased kidney apoptosis

increased renal tubule apoptosis

increased kidney cell proliferation

enlarged kidney

increased urine protein level

abnormal urine homeostasis

abnormal renal glomerular capsule morphology

abnormal glomerular capsule parietal layer morphology

increased glomerular capsule space

abnormal podocyte morphology

podocyte foot process effacement

podocyte hypertrophy

abnormal renal glomerulus basement membrane morphology

increased renal glomerulus basement membrane thickness

abnormal renal glomerulus morphology

abnormal glomerular mesangium morphology

cortical renal glomerulopathies

glomerulosclerosis

renal glomerulus fibrosis

abnormal renal tubule epithelium morphology

renal tubule atrophy

abnormal renal tubule morphology

proximal convoluted tubule brush border loss

dilated renal tubule

renal tubular necrosis

pale kidney

abnormal kidney physiology

kidney failure

Availability

Mouse Genotype

Rrm2b^em1Mem/Rrm2b^em1Mem

Rrm2b^em2Mem/Rrm2b^em2Mem

Rrm2b^{Gt(OST85254)Lex}/Rrm2b^{Gt(OST85254)Lex}

Rrm2b^tm1Ynak/Rrm2b^tm1Ynak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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