Symbol Name ID |
Tmc1
transmembrane channel-like gene family 1 MGI:2151016 |
* | Aspects of the system are reported to show a normal phenotype. |
! | Indicates phenotype varies with strain background. |
Darker colors indicate more annotations |
Human Phenotypes | Abnormal vestibular function |
Sensorineural hearing impairment |
Tinnitus |
Disease(s) Associated with TMC1 | |||
autosomal dominant nonsyndromic deafness 36 | |||
autosomal recessive nonsyndromic deafness 7 |
Mouse Phenotypes | hearing/vestibular/ear phenotype |
abnormal ear morphology |
abnormal outer hair cell stereociliary bundle morphology |
cochlear inner hair cell degeneration |
cochlear outer hair cell degeneration |
cochlear hair cell degeneration |
abnormal scala media morphology |
abnormal organ of Corti supporting cell morphology |
abnormal Deiters cell morphology |
Deiters cell degeneration |
organ of Corti degeneration |
abnormal stria vascularis morphology |
abnormal tectorial membrane morphology |
cochlear degeneration |
vestibular saccular macula degeneration |
abnormal otolith morphology |
abnormal hair cell mechanoelectric transduction |
abnormal hearing physiology |
increased or absent threshold for auditory brainstem response |
impaired hearing |
deafness |
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Availability | Mouse Genotype | |||||||||||||||||||||
Tmc1baringo/Tmc1baringo | ||||||||||||||||||||||
Tmc1dn/Tmc1dn | ||||||||||||||||||||||
Tmc1nice/Tmc1nice | ||||||||||||||||||||||
Tmc1stitch/Tmc1stitch | *! | |||||||||||||||||||||
Tmc1tm1.1Ajg/Tmc1tm1.1Ajg | ||||||||||||||||||||||
Tmc1dn/Tmc1+ | * | |||||||||||||||||||||
Tmc1Mhdabth/Tmc1+ |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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