Symbol
Name
ID

Rnf168
ring finger protein 168
MGI:1917488

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased circulating IgA concentration	Decreased circulating IgG concentration	Decreased circulating total IgM	Chronic sinusitis	Recurrent sinusitis	Generalized lymphadenopathy	Otitis media	Pneumonia	Recurrent pneumonia	Immunodeficiency	Recurrent viral infections
Disease(s) Associated with RNF168
RIDDLE syndrome

Mouse Phenotypes

immune system phenotype

abnormal thymus morphology

enlarged thymus

increased DN3 thymocyte number

abnormal class switch recombination

abnormal T cell receptor delta chain V(D)J recombination

increased double-negative T cell number

increased eosinophil cell number

decreased gamma-delta T cell number

abnormal spleen morphology

decreased IgG1 level

decreased IgG2a level

decreased IgG3 level

decreased IgG level

Availability

Mouse Genotype

Rnf168^{Gt(156B6)Cmhd}/Rnf168^{Gt(156B6)Cmhd}

Rnf168^{Gt(405F11)Cmhd}/Rnf168^{Gt(405F11)Cmhd}

Rnf168^{tm2b(EUCOMM)Hmgu}/Rnf168^{tm2b(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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