Symbol
Name
ID

Cdh23
cadherin related 23 (otocadherin)
MGI:1890219

Phenotype annotations related to hearing/vestibular/ear

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal vestibular function	Prelingual sensorineural hearing impairment	Hearing impairment
Disease(s) Associated with CDH23	Abnormal vestibular function	Prelingual sensorineural hearing impairment	Hearing impairment
autosomal recessive nonsyndromic deafness 12
Usher syndrome type 1D

Mouse Phenotypes

hearing/vestibular/ear phenotype

abnormal inner hair cell kinocilium morphology

abnormal outer hair cell kinocilium morphology

abnormal outer hair cell kinocilium location or orientation

abnormal ear position

abnormal ear morphology

abnormal inner ear morphology

abnormal cochlea morphology

abnormal cochlear sensory epithelium morphology

abnormal cochlear hair cell morphology

decreased cochlear hair cell number

decreased cochlear inner hair cell number

decreased cochlear outer hair cell number

abnormal cochlear hair cell stereociliary bundle morphology

abnormal cochlear hair cell inter-stereocilial links morphology

abnormal cochlear hair bundle tip links morphology

abnormal inner hair cell stereociliary bundle morphology

abnormal orientation of inner hair cell stereociliary bundles

decreased inner hair cell stereocilia number

short inner hair cell stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal outer hair cell stereociliary bundle morphology

short outer hair cell stereocilia

absent outer hair cell stereocilia

decreased outer hair cell stereocilia number

decreased cochlear hair cell stereocilia number

cochlear inner hair cell degeneration

abnormal cochlear outer hair cell morphology

cochlear outer hair cell degeneration

cochlear hair cell degeneration

abnormal organ of Corti morphology

organ of Corti degeneration

abnormal stria vascularis morphology

stria vascularis degeneration

abnormal vestibular hair cell stereociliary bundle morphology

vestibular saccular macula degeneration

vestibular saccular degeneration

abnormal otolith morphology

abnormal ear physiology

abnormal cochlear hair cell physiology

abnormal cochlear outer hair cell physiology

absent cochlear microphonics

abnormal hair cell mechanoelectric transduction

abnormal hearing physiology

abnormal hearing electrophysiology

abnormal auditory brainstem response

increased or absent threshold for auditory brainstem response

abnormal cochlear nerve compound action potential

abnormal distortion product otoacoustic emission

absent distortion product otoacoustic emissions

increased susceptibility to age-related hearing loss

increased susceptibility to noise-induced hearing loss

impaired hearing

deafness

abnormal vestibular system physiology

absent linear vestibular evoked potential

Availability

Mouse Genotype

Cdh23^12J/Cdh23^12J

Cdh23^ahl/Cdh23^ahl

Cdh23^Jera/Cdh23^Jera

Cdh23^sals/Cdh23^sals

Cdh23^tm1.1Kjn/Cdh23^tm1.1Kjn

Cdh23^tm1.2Ugds/Cdh23^tm1.2Ugds

Cdh23^tm2.1Kjn/Cdh23^tm2.1Kjn

Cdh23^v-2J/Cdh23^v-2J

Cdh23^v-4J/Cdh23^v-4J

Cdh23^v-5J/Cdh23^v-5J

Cdh23^v-6J/Cdh23^v-6J

Cdh23^v-7J/Cdh23^v-7J

Cdh23^v-8J/Cdh23^v-8J

Cdh23^v-9J/Cdh23^v-9J

Cdh23^v-10J/Cdh23^v-10J

Cdh23^v-11J/Cdh23^v-11J

Cdh23^v-Alb/Cdh23^v-Alb

Cdh23^v-bus/Cdh23^v-bus

Cdh23^v-df/Cdh23^v-df

Cdh23^v-J/Cdh23^v-J

Cdh23^v-ngt/Cdh23^v-ngt

Cdh23^v/Cdh23^v

Cdh23^12J/Cdh23^v-2J

Cdh23^Jera/Cdh23⁺

Cdh23^sals/Cdh23^v-2J

Cdh23^v-2J/Cdh23⁺

Cdh23^v-3J/Cdh23⁺

Cdh23^v/Cdh23⁺

Cdh23^tm1.1Ugds/Cdh23^tm1.1Ugds
Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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