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Symbol
Name
ID

Icosl
icos ligand
MGI:1354701

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased circulating immunoglobulin concentration	Myelokathexis	Decreased total neutrophil count	Decreased total lymphocyte count	Decreased class-switched memory B cell proportion	Myelodysplasia
Disease(s) Associated with ICOSLG
immunodeficiency 119

Mouse Phenotypes

abnormal class switch recombination

abnormal T cell differentiation

abnormal T-helper 2 cell differentiation

abnormal spleen morphology

small spleen

abnormal spleen germinal center morphology

decreased spleen germinal center number

decreased spleen germinal center size

abnormal immunoglobulin level

decreased IgA level

decreased IgE level

decreased IgG1 level

decreased IgG2a level

decreased IgG2b level

decreased IgG level

decreased IgM level

abnormal T-helper 2 physiology

Availability

Mouse Genotype

Icosl^tm1Cdon/Icosl^tm1Cdon

Icosl^tm1Kplm/Icosl^tm1Kplm

Icosl^tm1Mak/Icosl^tm1Mak

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 07/08/2026 MGI 6.24