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hairy/enhancer-of-split related with YRPW motif 2
Phenotype annotations related to cardiovascular system
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations

Mouse Phenotypes
cardiovascular system phenotype
abnormal cardiovascular system morphology
abnormal blood vessel morphology
abnormal pulmonary artery morphology
pulmonary artery stenosis
decreased aorta wall thickness
liver vascular congestion
pulmonary vascular congestion
visceral vascular congestion
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
myocardial fiber disarray
abnormal ventricle myocardium morphology
heart left ventricle hypertrophy
heart right ventricle hypertrophy
abnormal cardiac epithelial to mesenchymal transition
abnormal heart development
overriding aortic valve
abnormal atrioventricular valve morphology
abnormal mitral valve morphology
thick mitral valve cusps
abnormal tricuspid valve morphology
tricuspid valve atresia
tricuspid valve stenosis
atrial septal defect
ostium secundum atrial septal defect
patent cardiac foramen ovale
dilated heart atrium
abnormal endocardium morphology
abnormal heart septum morphology
abnormal interventricular septum morphology
absent interventricular septum membranous part
perimembraneous ventricular septal defect
muscular ventricular septal defect
ventricular septal defect
abnormal heart shape
increased heart weight
enlarged heart
cardiac hypertrophy
abnormal semilunar valve morphology
abnormal aortic valve cusp morphology
aortic valve stenosis
thick aortic valve
abnormal pulmonary valve cusp morphology
pulmonary valve stenosis
thick pulmonary valve
abnormal heart ventricle morphology
abnormal heart left ventricle morphology
dilated heart left ventricle
dilated heart right ventricle
thin ventricular wall
cardiac fibrosis
cardiac interstitial fibrosis
decreased cardiac muscle contractility
decreased ventricle muscle contractility
atrioventricular valve regurgitation
mitral valve regurgitation
tricuspid valve regurgitation
aortic valve regurgitation
decreased heart rate
abnormal myocardial fiber physiology
increased response of heart to induced stress
congestive heart failure
Availability Mouse Genotype
Hey2tm1Gess/Hey2tm1Gess ! ! !
Hey2tm1Mtc/Hey2tm1Mtc * ! ! ! ! ! ! ! !
Tg(Myh6-cre)2182Mds/0  (conditional)
Tg(Nkx2-5-cre)9Eno/0  (conditional)
Tg(Tagln-cre)1Her/0  (conditional)
Tg(Tek-cre)1Ywa/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory