Symbol
Name
ID

Afdn
afadin, adherens junction formation factor
MGI:1314653

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal radial glial cell morphology

increased radial glial cell number

abnormal neural tube morphology

abnormal embryonic neuroepithelium morphology

abnormal neural tube closure

abnormal telencephalon development

thin cortical plate

abnormal cortical ventricular zone morphology

abnormal hindbrain development

increased brain size

abnormal hippocampus morphology

abnormal hippocampus CA1 region morphology

abnormal hippocampus pyramidal cell morphology

ectopic hippocampus pyramidal cells

abnormal cerebral cortex morphology

abnormal cerebral cortex lamination

abnormal neocortex morphology

increased neocortex size

abnormal nervous system tract morphology

increased neuronal precursor cell number

abnormal synapse morphology

abnormal presynapse morphology

decreased synapse density

ectopic neuron

abnormal excitatory postsynaptic potential

decreased prepulse inhibition

Availability

Mouse Genotype

Afdn^tm1Mrcr/Afdn^tm1Mrcr

Afdn^tm1Ytk/Afdn^tm1Ytk

Afdn^em1(IMPC)Mbp/Afdn⁺

Afdn^tm1.1Lfr/Afdn^tm1.1Lfr
Neurod6^tm1(cre)Kan/Neurod6⁺ (conditional)

Afdn^{tm1c(EUCOMM)Hmgu}/Afdn^{tm1c(EUCOMM)Hmgu}
Emx1^tm1(cre)Krj/Emx1⁺ (conditional)

Afdn^tm2Ytk/Afdn^tm2Ytk
Tg(Camk2a-cre)1Gsc/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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