Symbol
Name
ID

Lama5
laminin, alpha 5
MGI:105382

Phenotype annotations related to renal/urinary system

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Focal segmental glomerulosclerosis	Nephrotic syndrome	Steroid-resistant nephrotic syndrome	Stage 5 chronic kidney disease
Disease(s) Associated with LAMA5
nephrotic syndrome type 26

Mouse Phenotypes

renal/urinary system phenotype

abnormal glomerular capillary endothelium morphology

abnormal glomerular capillary morphology

abnormal mesangial cell morphology

increased kidney apoptosis

kidney cyst

polycystic kidney

enlarged kidney

increased urine protein level

hematuria

tubulointerstitial nephritis

abnormal kidney morphology

abnormal renal glomerular capsule morphology

abnormal podocyte morphology

podocyte foot process effacement

abnormal renal glomerulus basement membrane morphology

increased renal glomerulus basement membrane thickness

expanded mesangial matrix

glomerulosclerosis

renal glomerulus fibrosis

abnormal kidney development

renal interstitial fibrosis

small kidney

dilated renal tubule

renal cast

absent kidney

absent ureter

impaired branching involved in ureteric bud morphogenesis

abnormal kidney physiology

kidney failure

Availability

Mouse Genotype

Lama5^b2b2966.1Clo/Lama5^b2b2966.1Clo

Lama5^mpc205H/Lama5^mpc205H

Lama5^tm1Jhm/Lama5^tm1Jhm

Lama5^tm3Jhm/Lama5^tm3Jhm

Lama5^mpc205H/Lama5⁺

Lama5^tm3Jhm/Lama5^tm3Jhm
Tg(Nphs1-flpo)1Jhm/0 (conditional)

Lama5^tm2Jhm/Lama5^tm1Jhm
Tg(NPHS2-cre)295Lbh/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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