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Symbol
Name
ID

Pdcd1
programmed cell death 1
MGI:104879

Phenotype annotations related to immune system

Darker colors indicate more annotations

Human Phenotypes

Leukopenia

Pericarditis

Subacute progressive viral hepatitis

Liver abscess

Lupus nephritis

Nephritis

Abnormality of the immune system

Malar rash

Decreased serum complement C3

Decreased serum complement C4

Perinuclear antineutrophil antibody positivity

Antinuclear antibody positivity

Anti-dsDNA antibody positivity

Antiphospholipid antibody positivity

Systemic lupus erythematosus

Disease(s) Associated with PDCD1

hepatocellular carcinoma

systemic lupus erythematosus

Mouse Phenotypes

increased B cell proliferation

enlarged spleen

abnormal leukopoiesis

abnormal myelopoiesis

decreased B-1 B cell number

increased B-1 B cell number

increased B cell number

increased T-helper 1 cell number

decreased CD8-positive, alpha-beta T cell number

decreased regulatory T cell number

increased regulatory T cell number

increased lymphocyte cell number

abnormal immunoglobulin level

increased IgA level

increased IgG2b level

increased IgG3 level

increased IgM level

abnormal T cell activation

abnormal cytokine secretion

increased interferon-gamma secretion

increased susceptibility to experimental autoimmune encephalomyelitis

increased autoantibody level

increased inflammatory response

arthritis

glomerulonephritis

abnormal response to transplant

Availability

Mouse Genotype

Pdcd1^tm1.1Liux/Pdcd1^tm1.1Liux

Pdcd1^tm1.1Shr/Pdcd1^tm1.1Shr

Pdcd1^tm1Hon/Pdcd1^tm1Hon

Pdcd1^tm1Llc/Pdcd1^tm1Llc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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