|
Symbol Name ID |
Mlh1
mutL homolog 1 MGI:101938 |
| Darker colors indicate more annotations |
| Human Phenotypes | Leukemia |
Hematological neoplasm |
Lymphoma |
Non-Hodgkin lymphoma |
T-cell lymphoma |
Adenoma sebaceum |
Salivary gland neoplasm |
Breast carcinoma |
Neoplasm of the rectum |
Adenocarcinoma of the colon |
Hereditary nonpolyposis colorectal carcinoma |
Adenomatous colonic polyposis |
Colon cancer |
Intestinal polyposis |
Neoplasm of the stomach |
Neoplasm of the liver |
Hepatocellular carcinoma |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Benign gastrointestinal tract tumors |
Adenocarcinoma of the small intestine |
Duodenal adenocarcinoma |
Pituitary adenoma |
Neoplasm of the thyroid gland |
Ovarian neoplasm |
Endometrial carcinoma |
Uterine leiomyosarcoma |
Renal neoplasm |
Renal cell carcinoma |
Benign genitourinary tract neoplasm |
Malignant genitourinary tract tumor |
Urinary tract neoplasm |
Transitional cell carcinoma of the bladder |
Sebaceous gland carcinoma |
Neoplasm of the skin |
Basal cell carcinoma |
Plexiform neurofibroma |
Rhabdomyosarcoma |
Neoplasm of the skeletal system |
Astrocytoma |
Pleomorphic xanthoastrocytoma |
Ependymoma |
Glioblastoma multiforme |
Oligodendroglioma |
Benign neoplasm of the central nervous system |
Medulloblastoma |
Neuroblastoma |
Alveolar cell carcinoma |
Non-small cell lung carcinoma |
Lung adenocarcinoma |
Laryngeal carcinoma |
| Disease(s) Associated with MLH1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| colorectal cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||
| hereditary nonpolyposis colorectal cancer type 2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
| lung cancer | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Lynch syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||
| mismatch repair cancer syndrome | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Muir-Torre syndrome |
| Mouse Phenotypes | increased gastrointestinal tumor incidence |
increased intestinal adenocarcinoma incidence |
increased small intestine adenocarcinoma incidence |
increased intestinal adenoma incidence |
increased T cell derived lymphoma incidence |
increased skin tumor incidence |
increased basal cell carcinoma incidence |
increased adenoma incidence |
increased lymphoma incidence |
increased B cell derived lymphoma incidence |
increased carcinoma incidence |
increased adenocarcinoma incidence |
increased lung carcinoma incidence |
increased squamous cell carcinoma incidence |
increased uterus tumor incidence |
increased tumor incidence |
|
| Availability | Mouse Genotype | ||||||||||||||||
| Mlh1tm1Lisk/Mlh1tm1Lisk | |||||||||||||||||
| Mlh1tm1Mse/Mlh1tm1Mse | |||||||||||||||||
| Mlh1tm1Rak/Mlh1tm1Rak | |||||||||||||||||
| Mlh1tm1Wed/Mlh1tm1Wed | |||||||||||||||||
| Mlh1tm1Rak/Mlh1+ | |||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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