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Gene Expression Data
Assay Details
Assay
Reference: J:335681 Schlienger S, et al., Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control. Sci Adv. 2023 May 12;9(19):eadd5501
Assay type: Immunohistochemistry
MGI Accession ID: MGI:8210427
Gene symbol: Robo3
Gene name: roundabout guidance receptor 3
Results
Specimen 2C E10.5: embryonic day 10.5 (more )
Note: Section from the level of the forelimb. Double labeled: red - Robo3; green - Arhgef7 (assay MGI:8210426).
Structure Cell Type Level Pattern Image Note
TS17: future spinal cord commissural neuron Present 2C E10.5 Arhgef7/Robo3 zoom , 2C E10.5 Robo3 , 2C E10.5 Arhgef7/Robo3 Robo3 is a marker of commissural neurons. Expression colocalizes with Arhgef7.
Specimen 2C E11.5: embryonic day 11.5 (more )
Note: Section from the level of the forelimb. Double labeled: red - Robo3; green - Arhgef7 (assay MGI:8210426).
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present 2C E11.5 Arhgef7/Robo3 , 2C E11.5 Arhgef7/Robo3 zoom , 2C E11.5 Robo3 Robo3 is a marker of commissural neurons. Expression colocalizes with Arhgef7.
Specimen 4E E10.5: embryonic day 10.5 (more )
Note: Section from the level of the forelimb. Double labeled: red - Robo3; green - Git1 (assay MGI:8210428).
Structure Cell Type Level Pattern Image Note
TS17: future spinal cord commissural neuron Present 4E E10.5 Robo3 , 4E E10.5 Git1/Robo3 zoom , 4E E10.5 Git1/Robo3 Robo3 is a marker of commissural neurons. Expression colocalizes with Git1.
Specimen 4E E11.5: embryonic day 11.5 (more )
Note: Section from the level of the forelimb. Double labeled: red - Robo3; green - Git1 (assay MGI:8210428).
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present 4E E11.5 Git1/Robo3 , 4E E11.5 Robo3 , 4E E11.5 Git1/Robo3 zoom Robo3 is a marker of commissural neurons. Expression colocalizes with Git1.
Specimen 7A Control: embryonic day 11.5; Arhgef7tm1c(EUCOMM)Wtsi/Arhgef7+ (more )
Note: Section from the level of the forelimb.
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present 7A Control , 7A Control zoom
Specimen 7A Arhgef7het left: embryonic day 11.5; Arhgef7tm1b(EUCOMM)Wtsi/Arhgef7tm1c(EUCOMM)Wtsi (more )
Note: Section from the level of the forelimb.
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present Regionally restricted 7A Arhgef7het left , 7A Arhgef7het left zoom In Arhgef7<het> spinal cord, commissural axons aberrantly invade the motor column and form a wider axon tract compared to control mice.
Specimen 7A Arhgef7het right: embryonic day 11.5; Arhgef7tm1b(EUCOMM)Wtsi/Arhgef7tm1c(EUCOMM)Wtsi (more )
Note: Section from the level of the forelimb.
Structure Cell Type Level Pattern Image Note
TS19: future spinal cord commissural neuron Present Regionally restricted 7A Arhgef7het right zoom , 7A Arhgef7het right In Arhgef7<het> spinal cord, commissural axons aberrantly invade the motor column and form a wider axon tract compared to control mice.
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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03/25/2025
MGI 6.24 		The Jackson Laboratory