| hm | homozygous | ht | heterozygous | tg | involves transgenes | √ | phenotype observed |
| cn | conditional genotype | cx | complex: > 1 genome feature | ot | other: hemizygous, indeterminate,... | N | normal phenotype |
Background:
| Affected Systems | |
|---|---|
behavior/neurological
|
√ |
|
abnormal motor capabilities/coordination/movement
|
√ |
|
impaired righting response
|
√ |
|
limb grasping
|
√ |
|
abnormal posture
|
√ |
|
decreased locomotor activity
|
√ |
|
decreased vocalization
|
√ |
|
growth/size/body
|
√ |
|
decreased body weight
|
√ |
|
postnatal growth retardation
|
√ |
|
slow postnatal weight gain
|
√ |
|
homeostasis/metabolism
|
√ |
|
increased phenylalanine level
|
√ |
|
decreased nervous system dopamine level
|
√ |
|
decreased noradrenaline level
|
√ |
|
decreased serotonin level
|
√ |
|
decreased brain tyrosine 3-monooxygenase activity
|
√ |
|
liver/biliary system
|
√ |
|
abnormal liver morphology
|
√ |
|
mortality/aging
|
√ |
|
postnatal lethality, complete penetrance
|
√ |
|
prenatal lethality prior to heart atrial septation
|
√ |
|
nervous system
|
√ |
|
decreased nervous system dopamine level
|
√ |
|
decreased brain tyrosine 3-monooxygenase activity
|
√ |
|
abnormal brain morphology
|
√ |
