Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1
show or hide all annotated terms Sex:
adipose tissue		√
decreased total body fat amount		√
decreased white fat cell size		√
behavior/neurological		√
behavior/neurological phenotype		N
abnormal locomotor circadian rhythm		√
endocrine/exocrine glands	√	√
enlarged pancreatic islets		√
Meibomian gland atrophy	√	√
decreased insulin secretion		√
increased sebum secretion		√
growth/size/body		√
decreased body weight		√
decreased susceptibility to diet-induced obesity		√
homeostasis/metabolism	√	√
homeostasis/metabolism phenotype		N
decreased susceptibility to diet-induced obesity		√
increased respiratory quotient		√
abnormal glucose homeostasis		√
decreased insulin secretion		√
hyperglycemia		√
decreased circulating insulin level		√
abnormal gluconeogenesis		√
impaired glucose tolerance		√
abnormal lipid level		√
decreased circulating HDL cholesterol level		√
increased circulating cholesterol level		√
increased circulating HDL cholesterol level		√
increased circulating LDL cholesterol level		√
increased circulating VLDL cholesterol level		√
increased circulating free fatty acids level		√
decreased circulating VLDL triglyceride level		√
increased circulating triglyceride level		√
increased liver triglyceride level		√
increased skeletal muscle triglyceride level		√
abnormal enzyme/coenzyme activity	√	√
integument	√	√
Meibomian gland atrophy	√	√
increased sebum secretion		√
liver/biliary system		√
increased liver triglyceride level		√
increased susceptibility to diet-induced hepatic steatosis		√
muscle		√
increased skeletal muscle triglyceride level		√
vision/eye	√	√
Meibomian gland atrophy	√	√