| hm | homozygous | ht | heterozygous | tg | involves transgenes | √ | phenotype observed |
| cn | conditional genotype | cx | complex: > 1 genome feature | ot | other: hemizygous, indeterminate,... | N | normal phenotype |
Background:
| Affected Systems | ||||
|---|---|---|---|---|
|
||||
cellular
|
√ | √ | ||
|
abnormal anterior visceral endoderm cell migration
|
√ | √ | ||
|
craniofacial
|
√ | |||
|
abnormal craniofacial development
|
√ | |||
|
embryo
|
√ | √ | √ | |
|
abnormal anterior visceral endoderm cell migration
|
√ | √ | ||
|
abnormal rostral-caudal axis patterning
|
√ | |||
|
decreased embryo size
|
√ | |||
|
abnormal primitive streak morphology
|
√ | |||
|
embryonic-extraembryonic boundary constriction
|
√ | |||
|
abnormal embryonic tissue physiology
|
√ | |||
|
abnormal visceral yolk sac morphology
|
√ | |||
|
abnormal visceral yolk sac endoderm morphology
|
√ | |||
|
abnormal extraembryonic tissue physiology
|
√ | |||
|
abnormal extraembryonic endoderm formation
|
√ | |||
|
growth/size/body
|
√ | |||
|
decreased embryo size
|
√ | |||
|
homeostasis/metabolism
|
√ | |||
|
abnormal amino acid level
|
√ | |||
|
mortality/aging
|
√ | N | ||
|
mortality/aging
|
N | |||
|
embryonic lethality, complete penetrance
|
√ |
