Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
cn1
cn2
cn3
cn4
show or hide all annotated terms Sex:
     
cellular
√ √
decreased oocyte number
√
absent primordial germ cells
√
digestive/alimentary system
√
absent foregut
√
absent hindgut
√
embryo
√
abnormal dorsal-ventral axis patterning
√
abnormal rostral-caudal axis patterning
√
abnormal rhombomere morphology
√
fused somites
√
abnormal allantois morphology
√
endocrine/exocrine glands
√
abnormal ovarian follicle morphology
√
abnormal granulosa cell morphology
√
decreased tertiary ovarian follicle number
√
abnormal ovarian folliculogenesis
√
abnormal cumulus expansion
√
absent cumulus expansion
√
abnormal secondary ovarian follicle morphology
√
increased secondary ovarian follicle number
√
growth/size/body
√
kidney cyst
√
homeostasis/metabolism
√ √
increased circulating progesterone level
√ √
mortality/aging
√ √ √
premature death
√
postnatal lethality, complete penetrance
√
perinatal lethality, incomplete penetrance
√
embryonic lethality during organogenesis, complete penetrance
√
nervous system
√
abnormal hindbrain development
√
abnormal rhombomere morphology
√
renal/urinary system
N √
renal/urinary system phenotype
N
kidney cyst
√
decreased kidney collecting duct number
√
abnormal renal glomerulus morphology
√
abnormal kidney development
√
small kidney
√
hydroureter
√
reproductive system
√ √ √
decreased oocyte number
√
absent primordial germ cells
√
abnormal ovarian follicle morphology
√
abnormal granulosa cell morphology
√
decreased tertiary ovarian follicle number
√
abnormal ovarian folliculogenesis
√
abnormal cumulus expansion
√
absent cumulus expansion
√
abnormal secondary ovarian follicle morphology
√
increased secondary ovarian follicle number
√
decreased ovulation rate
√
decreased litter size
√ √
infertility
√ √