Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4
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cardiovascular system	N	√	√	√
cardiovascular system phenotype	N
pharyngeal arch artery hypoplasia		√	√	√
persistent truncus arteriosus		√	√	√
decreased heart left ventricle wall thickness		√	√	√
increased vascular permeability		√	√	√
craniofacial	√	√	√	√
pharyngeal arch artery hypoplasia		√	√	√
flat forehead	√	√	√	√
facial cleft	√
embryo		√	√	√
pharyngeal arch artery hypoplasia		√	√	√
growth/size/body	√	√	√	√
flat forehead	√	√	√	√
facial cleft	√
mortality/aging	√	√	√	√
lethality throughout fetal growth and development	√	√	√	√
embryonic lethality during organogenesis, complete penetrance		√	√	√