Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
hm1
cx2
show or hide all annotated terms Sex:
 
behavior/neurological
√ √ √
lethargy
√ √
abnormal suckling behavior
√
increased anxiety-related response
√ √
tremors
√ √
ataxia
√ √
impaired coordination
√ √
abnormal gait
√ √
decreased locomotor activity
√
cellular
√ √ √
abnormal male germ cell morphology
√
abnormal spermatid morphology
√
astrocytosis
√ √
microgliosis
√ √
abnormal mitochondrial morphology
√
abnormal peroxisome morphology
√
digestive/alimentary system
√ √
abnormal intestinal absorption
√ √
endocrine/exocrine glands
√
abnormal testis morphology
√
abnormal seminiferous tubule morphology
√
seminiferous tubule degeneration
√
small testis
√
growth/size/body
√ √ √
decreased body weight
√ √
postnatal growth retardation
√ √ √
hematopoietic system
√ √
microgliosis
√ √
homeostasis/metabolism
√ √ √
abnormal lipid homeostasis
√ √ √
abnormal lipid level
√ √ √
abnormal bile salt level
√ √ √
decreased fatty acids level
√
increased fatty acids level
√ √
immune system
√ √
microgliosis
√ √
liver/biliary system
√
microvesicular hepatic steatosis
√
mortality/aging
√ √ √
premature death
√ √
neonatal lethality, incomplete penetrance
√
postnatal lethality, incomplete penetrance
√ √ √
muscle
√
hypotonia
√
nervous system
√ √ N
nervous system phenotype
N N N
astrocytosis
√ √
microgliosis
√ √
Purkinje cell degeneration
√ √
axon degeneration
√ √
reproductive system
√ √
abnormal gametogenesis
√ √
abnormal male germ cell morphology
√
abnormal spermatogenesis
√
abnormal spermatid morphology
√
abnormal male reproductive system morphology
√
abnormal testis morphology
√
abnormal seminiferous tubule morphology
√
seminiferous tubule degeneration
√
small testis
√
abnormal epididymis morphology
√
male infertility
√
reduced male fertility
√
vision/eye
√ √
cataract
√ √