Key:
hm homozygous ht heterozygous tg involves transgenes √ phenotype observed
cn conditional genotype  cx complex: > 1 genome feature ot other: hemizygous, indeterminate,... N normal phenotype
Genotype/
Background:
Phenotypes:
Affected Systems
ot1
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nervous system
√
decreased retina cone cell number
√
absent photoreceptor outer segment
√
vision/eye
√
abnormal retina morphology
√
disorganized retina inner nuclear layer
√
disorganized retina outer nuclear layer
√
abnormal retina photoreceptor layer morphology
√
decreased retina cone cell number
√
absent photoreceptor outer segment
√
abnormal eye electrophysiology
√
abnormal cone electrophysiology
√