Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	hm1		hm2	hm3	cx4	cx5		cx6		cx7
show or hide all annotated terms Sex:
cardiovascular system	√	√			N	√		N
cardiovascular system phenotype					N			N
abnormal lung vasculature morphology	√	√
abnormal placenta vasculature	√					√
vascular smooth muscle hypertrophy	√	√
heart right ventricle hypertrophy	√	√
increased right ventricle systolic pressure	√	√
pulmonary hypertension	√	√
hypertension						√
increased systemic arterial systolic blood pressure						√
increased vascular smooth muscle cell proliferation	√	√
cellular	√	√	√			√	√
increased vascular smooth muscle cell proliferation	√	√
increased hepatocyte karyomegaly			√
maternal effect	√	√				√	√
embryo	√				√	√		N
embryo phenotype								N
abnormal placenta morphology	√				√	√
abnormal placenta vasculature	√					√
small placenta	√					√
decreased placenta weight	√					√
endocrine/exocrine glands								√	√
abnormal thymus corticomedullary boundary morphology								√	√
small thymus								√	√
growth/size/body	√	√	√
heart right ventricle hypertrophy	√	√
decreased body weight			√
hematopoietic system	√	√	√					√	√
abnormal thymus corticomedullary boundary morphology								√	√
small thymus								√	√
increased double-negative T cell number								√	√
anemia								√	√
increased granulocyte number								√	√
increased eosinophil cell number								√	√
increased dendritic cell number	√	√
increased macrophage cell number								√	√
decreased leukocyte cell number								√	√
decreased T cell number			√
decreased double-positive T cell number								√	√
abnormal spleen red pulp morphology								√	√
small spleen								√	√
spleen hypoplasia								√	√
decreased immunoglobulin level								√	√
homeostasis/metabolism			√			√
decreased circulating serum albumin level			√
decreased circulating total protein level			√
cyanosis			√
abnormal enzyme/coenzyme level			√
increased urine protein level						√
abnormal nucleotide metabolism			√
immune system	√	√	√					√	√
abnormal thymus corticomedullary boundary morphology								√	√
small thymus								√	√
increased double-negative T cell number								√	√
increased granulocyte number								√	√
increased eosinophil cell number								√	√
increased dendritic cell number	√	√
increased macrophage cell number								√	√
decreased leukocyte cell number								√	√
decreased T cell number			√
decreased double-positive T cell number								√	√
abnormal spleen red pulp morphology								√	√
small spleen								√	√
spleen hypoplasia								√	√
decreased immunoglobulin level								√	√
abnormal dendritic cell physiology	√	√
lung inflammation								√	√
liver/biliary system			√
abnormal liver morphology			√
abnormal hepatocyte morphology			√
increased hepatocyte karyomegaly			√
decreased hepatocyte number			√
small liver			√
hepatic necrosis			√
mortality/aging			√			√	√	√	√
neonatal lethality, complete penetrance			√
postnatal lethality, complete penetrance						√	√	√	√
muscle	√	√
vascular smooth muscle hypertrophy	√	√
heart right ventricle hypertrophy	√	√
increased vascular smooth muscle cell proliferation	√	√
renal/urinary system					N	√		√	√
renal/urinary system phenotype					N			N
increased urine protein level						√
abnormal renal glomerulus morphology						√		√	√
abnormal renal tubule morphology								√	√
reproductive system				√
abnormal penile erection				√
priapism				√
respiratory system	√	√						√	√
abnormal lung vasculature morphology	√	√
lung inflammation								√	√
abnormal pulmonary alveolar system morphology	√	√
increased lung elastance	√	√
increased airway resistance	√	√
tachypnea								√	√
decreased lung compliance	√	√
abnormal pulmonary gas exchange	√	√
skeleton								√	√
abnormal costochondral joint morphology								√	√
abnormal rib morphology								√	√
normal phenotype										√
no abnormal phenotype detected										√