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Transgene Detail
Symbol: Tg(Foxp3-DTR/EGFP)23.2Spar
Name: transgene insertion 23.2, Tim Sparwasser
MGI ID: MGI:3849080
Synonyms: DEREG, Tg(Foxp3-DTR/EGFP)1Ebe
Transgene: Tg(Foxp3-DTR/EGFP)23.2Spar  Location: unknown  
Alliance: Tg(Foxp3-DTR/EGFP)23.2Spar page
Strain of Origin:  C57BL/6NCrl
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Foxp3-DTR/EGFP)23.2Spar expresses 1 gene
Mutation detailsThe RP23-267C15 bacterial artificial chromosome (BAC) containing at least ten mouse genes was obtained. This BAC was modified by targeting a simian diphtheria toxin receptor-enhanced green fluorescent protein (DTR-eGFP) fusion protein and an SV40 polyA element into the first exon of the Foxp3 (forkhead box P3) locus: none of the other loci on the BAC were mutated. Two high expressing lines (16.1 and 23.2) were established. Analysis revealed selective DTR-eGFP expression within the CD4+ T cell compartment, with the highest expression within the CD25+ subset. (J:125295)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:125295 Lahl K, et al., Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007 Jan 22;204(1):57-63
All:  142 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.22
The Jackson Laboratory