Phenotypes Associated with This Genotype

Genotype
MGI:7639924

hm1

• Allelic Composition: Kcnma1^em3Gpt/Kcnma1^em3Gpt
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

abnormal renal protein reabsorption ( J:325255 )

• amelioration of Ang II-induced proteinurea

abnormal podocyte morphology ( J:325255 )

• amelioration of angiotensin II (Ang-II) induced focal segmental sclerosis and foot process effacement

abnormal podocyte physiology ( J:325255 )

• absence of Ang II-induced big-conductance Ca2+-activated K+ (BK) currents and block of Ang II-induced decrease in intracellular potassium

homeostasis/metabolism

abnormal renal protein reabsorption ( J:325255 )

• amelioration of Ang II-induced proteinurea