Analysis Tools
mortality/aging
craniofacial
|
• at E18.5, the anterior cranial base is hypoplastic
• however, the basioccipital and cranial vault bones are relatively normal
|
|
• at E18.5, the basisphenoid is smaller than in wild-type controls
|
|
• at E18.5, less cartilage is detected in the mandibular coronoid, condylar, and angular processes
• however, Meckels cartilage is present
|
|
• at E18.5, the presphenoid bone is absent
|
|
• at E18.5, the zygomatic arch is less developed than in wild-type controls
|
|
• at E18.5, mandibular incisors have not erupted in the mandible
• however, clearly demarcated molar crypts are present
|
|
• at E18.5, the angular cartilage is hypoplastic with reduced mineralization
|
|
• at E18.5, the condylar cartilage is hypoplastic
|
|
• at E18.5, the coronoid process is hypoplastic
|
|
• at E18.5, the mandible is significantly shorter than in wild-type controls
|
|
• at E18.5, the zygomatic process of the maxillary bone is hypoplastic
|
|
• at E18.5, the vomer bone is underdeveloped
|
|
• at E14.5, expression of several proteins involved in palatal shelf adhesion/fusion, including chondroitin sulfate proteoglycan, TGFB3, TWIST1, and beta-catenin, is absent in the palatal shelf epithelium
• however, mesenchymal expression of chondroitin sulfate proteoglycan expression is unaffected and no differences in proliferation or apoptosis are detected in the palatal shelves at E14.5
|
|
• at E18.5, palatal shelves remain widely separated
• ex vivo, palatal shelves isolated from E13.5 embryos remain in contact with each other but fail to initiate the fusion process after 48 h of organ culture
|
cleft palate
(
J:288954
)
|
• at E18.5, cleft palate is evident in all mice examined
|
|
• at E14.5, palatal shelves are still oriented vertically, whereas wild-type palatal shelves have already elevated and begun to approximate each other
• however, palatal shelves are elevated above the tongue by E18.5
|
|
• at E18.5, mean nasal angle is significantly steeper than in wild-type controls
• however, nasal cartilage morphology is relatively normal
|
|
• at E14.5, expression of chondroitin sulfate proteoglycan is absent in the nasal septum, unlike in wild-type controls
|
|
• at E18.5, the nose is described as downward-sloping
|
short snout
(
J:288954
)
|
• at E18.5, mean nasal length is significantly shorter than in wild-type controls
• however, mean head length is relatively normal
|
skeleton
|
• at E18.5, the anterior cranial base is hypoplastic
• however, the basioccipital and cranial vault bones are relatively normal
|
|
• at E18.5, the basisphenoid is smaller than in wild-type controls
|
|
• at E18.5, less cartilage is detected in the mandibular coronoid, condylar, and angular processes
• however, Meckels cartilage is present
|
|
• at E18.5, the presphenoid bone is absent
|
|
• at E18.5, the zygomatic arch is less developed than in wild-type controls
|
|
• at E18.5, mandibular incisors have not erupted in the mandible
• however, clearly demarcated molar crypts are present
|
|
• at E18.5, the angular cartilage is hypoplastic with reduced mineralization
|
|
• at E18.5, the condylar cartilage is hypoplastic
|
|
• at E18.5, the coronoid process is hypoplastic
|
|
• at E18.5, the mandible is significantly shorter than in wild-type controls
|
|
• at E18.5, the zygomatic process of the maxillary bone is hypoplastic
|
|
• at E18.5, the vomer bone is underdeveloped
|
|
• at E18.5, reduced mineralized regions as well as less cartilage are observed in the mandibular coronoid, condylar, and angular processes
|
respiratory system
|
• at E18.5, mean nasal angle is significantly steeper than in wild-type controls
• however, nasal cartilage morphology is relatively normal
|
|
• at E14.5, expression of chondroitin sulfate proteoglycan is absent in the nasal septum, unlike in wild-type controls
|
digestive/alimentary system
|
• at E14.5, expression of several proteins involved in palatal shelf adhesion/fusion, including chondroitin sulfate proteoglycan, TGFB3, TWIST1, and beta-catenin, is absent in the palatal shelf epithelium
• however, mesenchymal expression of chondroitin sulfate proteoglycan expression is unaffected and no differences in proliferation or apoptosis are detected in the palatal shelves at E14.5
|
|
• at E18.5, palatal shelves remain widely separated
• ex vivo, palatal shelves isolated from E13.5 embryos remain in contact with each other but fail to initiate the fusion process after 48 h of organ culture
|
cleft palate
(
J:288954
)
|
• at E18.5, cleft palate is evident in all mice examined
|
|
• at E14.5, palatal shelves are still oriented vertically, whereas wild-type palatal shelves have already elevated and begun to approximate each other
• however, palatal shelves are elevated above the tongue by E18.5
|
growth/size/body
|
• at E18.5, mandibular incisors have not erupted in the mandible
• however, clearly demarcated molar crypts are present
|
|
• at E14.5, expression of several proteins involved in palatal shelf adhesion/fusion, including chondroitin sulfate proteoglycan, TGFB3, TWIST1, and beta-catenin, is absent in the palatal shelf epithelium
• however, mesenchymal expression of chondroitin sulfate proteoglycan expression is unaffected and no differences in proliferation or apoptosis are detected in the palatal shelves at E14.5
|
|
• at E18.5, palatal shelves remain widely separated
• ex vivo, palatal shelves isolated from E13.5 embryos remain in contact with each other but fail to initiate the fusion process after 48 h of organ culture
|
cleft palate
(
J:288954
)
|
• at E18.5, cleft palate is evident in all mice examined
|
|
• at E14.5, palatal shelves are still oriented vertically, whereas wild-type palatal shelves have already elevated and begun to approximate each other
• however, palatal shelves are elevated above the tongue by E18.5
|
|
• at E18.5, mean nasal angle is significantly steeper than in wild-type controls
• however, nasal cartilage morphology is relatively normal
|
|
• at E14.5, expression of chondroitin sulfate proteoglycan is absent in the nasal septum, unlike in wild-type controls
|
|
• at E18.5, the nose is described as downward-sloping
|
short snout
(
J:288954
)
|
• at E18.5, mean nasal length is significantly shorter than in wild-type controls
• however, mean head length is relatively normal
|
