Phenotypes Associated with This Genotype

Genotype
MGI:5906764

• Allelic Composition: Dusp5^tm1.1Achn/Dusp5^tm1.1Achn; Rag2^tm1.1Cgn/Rag2^tm1.1Cgn
• Genetic Background: involves: C57BL/6NCrl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:218203 )

• circulating at 6 and 13 following N. brasiliensis infection

• in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days following N. brasiliensis infection

abnormal eosinophil physiology ( J:218203 )

• following N. brasiliensis infection, eosiniphils exhibit a cell intrinsic 2- to 3-fold increased proliferation and decreased apoptosis compared with cells from control mice

abnormal susceptibility to parasitic infection ( J:218203 )

• following N. brasiliensis infection, mice exhibit increased circulating eosinophils at 6 and 13 days compared with control mice

• following N. brasiliensis infection, mice exhibit an increased in eosinophils in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days compared with control mice

• following N. brasiliensis infection, mice exhibit lower worm burden compared with control mice

• treatment with antibodies to deplete NK cells does not alter phenotype

hematopoietic system

increased eosinophil cell number ( J:218203 )

• circulating at 6 and 13 following N. brasiliensis infection

• in the blood, bronchoalveolar lavage fluid, spleen and bone marrow at 14 days following N. brasiliensis infection

abnormal eosinophil physiology ( J:218203 )

• following N. brasiliensis infection, eosiniphils exhibit a cell intrinsic 2- to 3-fold increased proliferation and decreased apoptosis compared with cells from control mice